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hemoadsorption

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https://www.readbyqxmd.com/read/28665446/first-experience-on-bilirubin-removal-with-a-hemoadsorption-column-lixelle%C3%A2-in-a-child-with-cardiogenic-liver-injury
#1
Gabriella Bottari, Andrea Moscatelli, Enrico E Verrina, Franco Lerzo, Fabio S Taccone
INTRODUCTION: Hyperbilirubinemia may have deleterious effects on many organs, even after the neonatal age. Blood purification is effective in the treatment of hyperbilirubinemia. Recently some reports suggest the potential role of hemoadsorption columns in this setting. METHODS: We present the case of a 6-year-old child with severe hyperbilirubinemia due to congestive liver dysfunction, complicated by persistent inflammation, immunosuppression and catabolism syndrome (PICS)...
June 20, 2017: International Journal of Artificial Organs
https://www.readbyqxmd.com/read/28525674/continuous-hemoadsorption-with-a-cytokine-adsorber-during-sepsis-a-review-of-the-literature
#2
Khosrow S Houschyar, Malcolm N Pyles, Susanne Rein, Ina Nietzschmann, Dominik Duscher, Zeshaan N Maan, Kristian Weissenberg, Hubertus M Philipps, Catharina Strauss, Beate Reichelt, Frank Siemers
Sepsis is a well-recognized healthcare issue worldwide, ultimately resulting in significant mortality, morbidity and resource utilization during and after critical illness. In its most severe form, sepsis causes multi-organ dysfunction that produces a state of critical illness characterized by severe immune dysfunction and catabolism. Sepsis induces the activation of complement factor via 3 pathways and the release of inflammatory cytokines such as tumor necrosis factor alpha (TNF-α) and interleukin-1beta (IL-1β), resulting in a systemic inflammatory response...
May 29, 2017: International Journal of Artificial Organs
https://www.readbyqxmd.com/read/28525670/hemoadsorption-treatment-of-patients-with-acute-infective-endocarditis-during-surgery-with-cardiopulmonary-bypass-a-case-series
#3
Karl Träger, Christian Skrabal, Guenther Fischer, Thomas Datzmann, Janpeter Schroeder, Daniel Fritzler, Jan Hartmann, Andreas Liebold, Helmut Reinelt
INTRODUCTION: Infective endocarditis is a serious disease condition. Depending on the causative microorganism and clinical symptoms, cardiac surgery and valve replacement may be needed, posing additional risks to patients who may simultaneously suffer from septic shock. The combination of surgery bacterial spreadout and artificial cardiopulmonary bypass (CPB) surfaces results in a release of key inflammatory mediators leading to an overshooting systemic hyperinflammatory state frequently associated with compromised hemodynamic and organ function...
May 29, 2017: International Journal of Artificial Organs
https://www.readbyqxmd.com/read/28370393/removal-of-focal-segmental-glomerulosclerosis-fsgs-factor-supar-using-cytosorb
#4
Heiko Schenk, Janina Müller-Deile, Roland Schmitt, Jan Hinrich Bräsen, Hermann Haller, Mario Schiffer
Treatment of primary focal segmental glomerulosclerosis (FSGS) and its recurrence after kidney transplantation associated with rapid deterioration of kidney function remains to be challenging despite advances in immunosuppressive therapy. The presence of circulating factors has been postulated to be a pivotal player in the pathogenesis of FSGS, although suPAR and CLCF-1 have been identified as the most promising causative factors. The potential therapeutic effect of suPAR elimination in an FSGS patient using CytoSorb, a hemoadsorption device that gained attention in the cytokine elimination in septic patients, was studied...
March 29, 2017: Journal of Clinical Apheresis
https://www.readbyqxmd.com/read/28355595/use-of-hemoadsorption-in-a-case-of-severe-hepatic-failure-and-hyperbilirubinemia
#5
Andreas Faltlhauser, Frank Kullmann
No abstract text is available yet for this article.
2017: Blood Purification
https://www.readbyqxmd.com/read/28343448/hemoadsorption-by-cytosorb-in-septic-patients-a-case-series
#6
Klaus Kogelmann, Dominik Jarczak, Morten Scheller, Matthias Drüner
BACKGROUND: Septic shock, defined as life-threatening organ dysfunction caused by a dysregulated host response to infection, is a highly lethal condition that causes substantial morbidity and mortality among critically ill patients. One of the hallmarks of sepsis is the excessive release of cytokines and other inflammatory mediators causing refractory hypotension, tissue damage, metabolic acidosis and ultimately multiple organ failure. In this context, cytokine reduction by hemoadsorption represents a new concept for blood purification, developed to attenuate the overwhelming systemic levels of pro-inflammatory and anti-inflammatory mediators released in the early phase of sepsis...
March 27, 2017: Critical Care: the Official Journal of the Critical Care Forum
https://www.readbyqxmd.com/read/28237980/application-of-hemoadsorption-in-a-case-of-liver-cirrhosis-and-alcohol-related-steatohepatitis-with-preexisting-hepatitis-c-infection
#7
Stefan Büttner, Sammy Patyna, Benjamin Koch, Fabian Finkelmeier, Helmut Geiger, Christoph Sarrazin, Harald Farnik
No abstract text is available yet for this article.
2017: Blood Purification
https://www.readbyqxmd.com/read/27140295/treatment-of-post-cardiopulmonary-bypass-sirs-by-hemoadsorption-a-case-series
#8
Karl Träger, Daniel Fritzler, Guenther Fischer, Janpeter Schröder, Christian Skrabal, Andreas Liebold, Helmut Reinelt
The use of cardiopulmonary bypass (CPB) in cardiothoracic surgery results in a well-known activation of the immunologic response. In some cases, however, this triggered immunologic response may be excessive, leading to a severe systemic inflammatory response syndrome (SIRS) and induced organ dysfunction. For example, patients frequently develop hemodynamic instability with hypotension and low systemic vascular resistance. To date, different therapeutic approaches, such as steroids, have been tried to control this maladaptive postoperative SIRS response, yet definitive proof of clinical efficacy is missing...
May 16, 2016: International Journal of Artificial Organs
https://www.readbyqxmd.com/read/27097769/effectiveness-of-multiple-blood-cleansing-interventions-in-sepsis-characterized-in-rats
#9
Ivan Stojkovic, Mohamed Ghalwash, Xi Hang Cao, Zoran Obradovic
Sepsis is a serious, life-threatening condition that presents a growing problem in medicine, but there is still no satisfying solution for treating it. Several blood cleansing approaches recently gained attention as promising interventions that target the main site of problem development-the blood. The focus of this study is an evaluation of the theoretical effectiveness of hemoadsorption therapy and pathogen reduction therapy. This is evaluated using the mathematical model of Murine sepsis, and the results of over 2,200 configurations of single and multiple intervention therapies simulated on 5,000 virtual subjects suggest the advantage of pathogen reduction over hemoadsorption therapy...
April 21, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27079418/first-report-of-cytokine-removal-using-cytosorb%C3%A2-in-severe-noninfectious-inflammatory-syndrome-after-liver-transplantation
#10
Dana R Tomescu, Simona Olimpia Dima, Daniela Ungureanu, Mihai Popescu, Dan Tulbure, Irinel Popescu
INTRODUCTION: Emergency transplantation of a donor liver that is not matched for the major blood antigens can produce marked immune-mediated cytokine release that can cause donor graft loss. Control of the inflammatory response may be a key element in treatment. METHODS: We present the case of a 46-year-old man with primary graft nonfunction after liver transplantation who underwent emergency retransplantation with an ABO-incompatible graft. A severe inflammatory response syndrome (SIRS) was noted in the perioperioperative period of retransplantation...
May 16, 2016: International Journal of Artificial Organs
https://www.readbyqxmd.com/read/27059056/effect-of-hemoadsorption-during-cardiopulmonary-bypass-surgery-a-blinded-randomized-controlled-pilot-study-using-a-novel-adsorbent
#11
RANDOMIZED CONTROLLED TRIAL
Martin H Bernardi, Harald Rinoesl, Klaus Dragosits, Robin Ristl, Friedrich Hoffelner, Philipp Opfermann, Christian Lamm, Falk Preißing, Dominik Wiedemann, Michael J Hiesmayr, Andreas Spittler
BACKGROUND: Cardiopulmonary bypass (CPB) surgery initiates a systemic inflammatory response, which is associated with postoperative morbidity and mortality. Hemoadsorption (HA) of cytokines may suppress inflammatory responses and improve outcomes. We tested a new sorbent used for HA (CytoSorb™; CytoSorbents Europe GmbH, Berlin, Germany) installed in the CPB circuit on changes of pro- and anti-inflammatory cytokines levels, inflammation markers, and differences in patients' perioperative course...
April 9, 2016: Critical Care: the Official Journal of the Critical Care Forum
https://www.readbyqxmd.com/read/26991687/hemoadsorption-in-infection-associated-rhabdomyolysis
#12
Sven Suefke, Friedhelm Sayk, Martin Nitschke
No abstract text is available yet for this article.
October 2016: Therapeutic Apheresis and Dialysis
https://www.readbyqxmd.com/read/26368927/evaluation-of-the-cytosorb%C3%A2-hemoadsorptive-column-in-a-pig-model-of-severe-smoke-and-burn-injury
#13
Katharina Linden, Vittorio Scaravilli, Stefan F X Kreyer, Slava M Belenkiy, Ian J Stewart, Kevin K Chung, Leopoldo C Cancio, Andriy I Batchinsky
INTRODUCTION: Host inflammatory response to any form of tissue injury, including burn, trauma, or shock, has been well documented. After significant burns, cytokines can increase substantially within the first 24 h after injury and may contribute to subsequent organ failure. Hemoadsorption by cytokine-adsorbing columns may attenuate this maladaptive response, thereby improving outcomes. The aim of this study was to investigate the feasibility, technical safety, and efficacy of cytokine and myoglobin removal by early use of a cytokine absorbing column (CytoSorb) in a porcine model of smoke inhalation and burn injury...
November 2015: Shock
https://www.readbyqxmd.com/read/26349530/cytosorb-a-novel-therapeutic-approach-for-patients-with-septic-shock-a-case-report
#14
Burkhard Hinz, Oliver Jauch, Toralf Noky, Sigrun Friesecke, Peter Abel, Rolf Kaiser
INTRODUCTION: Hemoadsorption using CytoSorb has gained attention as a potential immunotherapy to control systemic inflammation and sepsis. We report on a patient with septic shock, successfully treated with CytoSorb therapy. METHODS: A 72-year-old male with periodically recurring infectious episodes was admitted with the suspicion of urosepsis. In the following hours his hemodynamic situation deteriorated markedly, exhibiting respiratory-metabolic acidosis, elevated inflammatory marker plasma levels, a severely disturbed coagulation, increased retention parameters, liver dysfunction, and confirmation of bacteria and leucocytes in urine...
August 2015: International Journal of Artificial Organs
https://www.readbyqxmd.com/read/26253638/improved-treatment-of-systemic-blood-infections-using-antibiotics-with-extracorporeal-opsonin-hemoadsorption
#15
Tohid F Didar, Mark J Cartwright, Martin Rottman, Amanda R Graveline, Nazita Gamini, Alexander L Watters, Daniel C Leslie, Tadanori Mammoto, Melissa J Rodas, Joo H Kang, Anna Waterhouse, Benjamin T Seiler, Patrick Lombardo, Elisabet I Qendro, Michael Super, Donald E Ingber
Here we describe development of an extracorporeal hemoadsorption device for sepsis therapy that employs commercially available polysulfone or polyethersulfone hollow fiber filters similar to those used clinically for hemodialysis, covalently coated with a genetically engineered form of the human opsonin Mannose Binding Lectin linked to an Fc domain (FcMBL) that can cleanse a broad range of pathogens and endotoxin from flowing blood without having to first determine their identity. When tested with human whole blood in vitro, the FcMBL hemoadsorption filter (FcMBL-HF) produced efficient (90-99%) removal of Gram negative (Escherichia coli) and positive (Staphylococcus aureus) bacteria, fungi (Candida albicans) and lipopolysaccharide (LPS)-endotoxin...
October 2015: Biomaterials
https://www.readbyqxmd.com/read/25833160/effects-of-hemoadsorption-with-a-novel-adsorbent-on-sepsis-in-vivo-and-in-vitro-study
#16
Jicheng Zhang, Zhiyong Peng, Donald Maberry, Jacob Volpe, Jeremy D Kimmel, William J Federspiel, John A Kellum
BACKGROUND/AIMS: Hemoadsorption may improve outcomes for sepsis by removing circulating cytokines. We tested a new sorbent used for hemoadsorption. METHODS: CTR sorbent beads were filled into columns of three sizes: CTR0.5 (0.5 ml), CTR1 (1.0 ml) and CTR2 (2.0 ml) and tested using IL-6 capture in vitro. Next, rats were subjected to cecal ligation and puncture and randomly assigned to hemoadsorption with CTR0.5, CTR1, CTR2 or sham treatment. Plasma biomarkers were measured...
2015: Blood Purification
https://www.readbyqxmd.com/read/25656010/first-successful-combination-of-ecmo-with-cytokine-removal-therapy-in-cardiogenic-septic-shock-a-case-report
#17
Frank Bruenger, Lukasz Kizner, Jan Weile, Michael Morshuis, Jan F Gummert
PURPOSE: A new hemoadsorption device intended as adjunctive treatment for patients with elevated cytokine levels in the setting of SIRS and sepsis has shown promising results. We report on the beneficial application of the device in a patient with cardiogenic septic shock receiving combined extracorporeal life support with rECMO, LVAD, and CVVH despite his highly septic condition. METHODS: A 39-year-old patient presented with fulminant ARDS and cardiogenic septic shock...
February 2015: International Journal of Artificial Organs
https://www.readbyqxmd.com/read/25653500/design-of-a-new-therapy-for-patients-with-chronic-kidney-disease-use-of-microarrays-for-selective-hemoadsorption-of-uremic-wastes-and-toxins-to-improve-homeostasis
#18
Mohammad Rashid Shahidi Bonjar, Leyla Shahidi Bonjar
The hypothesis proposed here would provide near to optimum homeostasis for patients with chronic kidney disease (CKD) without the need for hemodialysis. This strategy has not been described previously in the scientific literature. It involves a targeted therapy that may prevent progression of the disease and help to improve the well-being of CKD patients. It proposes a nanotechnological device, ie, a microarray-oriented homeostasis provider (MOHP), to improve homeostasis in CKD patients. MOHP would be an auxiliary kidney aid, and would improve the filtration functions that impaired kidneys cannot perform by their own...
2015: Drug Design, Development and Therapy
https://www.readbyqxmd.com/read/25538418/use-of-a-novel-hemoadsorption-device-for-cytokine-removal-as-adjuvant-therapy-in-a-patient-with-septic-shock-with-multi-organ-dysfunction-a-case-study
#19
Reshma Basu, Sunjay Pathak, Jyoti Goyal, Rajeev Chaudhry, Rati B Goel, Anil Barwal
CytoSorb(®) (CytoSorbents Corporation, USA) is a novel sorbent hemoadsorption device for cytokine removal. The aim of this study was to examine the clinical use of CytoSorb(®) in the management of patient with septic shock. We used this device as an adjuvant to stabilize a young patient with multi-organ failure and severe sepsis with septic shock. A 36-year-old female patient was hospitalized with the complaints of malaise, general body ache, and breathing difficulty and had a medical history of diabetes mellitus type II, hypertension, obstructive sleep apnea, hypothyroidism and morbid obesity...
December 2014: Indian Journal of Critical Care Medicine
https://www.readbyqxmd.com/read/25538412/alteco-endotoxin-hemoadsorption-in-gram-negative-septic-shock-patients
#20
Hoi Ping Shum, Yuk Wah Leung, Sin Man Lam, King Chung Chan, Wing Wa Yan
BACKGROUND AND AIMS: Severe sepsis and septic shock are common causes of mortality and morbidity in an intensive care unit setting. Endotoxin, derived from the outer membranes of Gram-negative bacteria, is considered a major factor in the pathogenesis of sepsis. This study investigated the effect of Alteco endotoxin hemoadsorption device on Gram-negative septic shock patients. MATERIALS AND METHODS: An open, controlled, prospective, randomized, single-center trial was conducted between February 2010 and June 2012...
December 2014: Indian Journal of Critical Care Medicine
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