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JOURNAL ARTICLE
Oscar Salvador Barrera-Vázquez, Juan Luis Escobar-Ramírez, Jacinto Santiago-Mejía, Omar Francisco Carrasco-Ortega, Gil Alfonso Magos-Guerrero
Peripheral venous hypertension has emerged as a prominent characteristic of venous disease (VD). This disease causes lower limb edema due to impaired blood transport in the veins. The phlebotonic drugs in use showed moderate evidence for reducing edema slightly in the lower legs and little or no difference in the quality of life. To enhance the probability of favorable experimental results, a virtual screening procedure was employed to identify molecules with potential therapeutic activity in VD. Compounds obtained from multiple databases, namely AC Discovery, NuBBE, BIOFACQUIM, and InflamNat, were compared with reference compounds...
December 5, 2023: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
#22
JOURNAL ARTICLE
Haim Shirin, Ian J Neeland, Donna H Ryan, Daniel de Luis, Albert Lecube, Zoltan Magos, Yael Kenan, Ruthie Amir, Daniel L Cohen, Odd Erik Johansen
BACKGROUND: The Epitomee Capsule (EC) is an, oral, self-use, bio-degradable device for weight management, composed of absorbent polymers that self-expands in the stomach (pH-sensitive) and creates a triangular shape, space-occupying super-absorbent gel structure. A recent study reported that 42 % of study completers obtained >5 % weight reduction at 12 weeks. We performed exploratory analyses of this study to evaluate its effect on cardiovascular risk factors and on self-reported satiety, between-meal snacking and meal-size...
December 2023: Obes Pillars
#23
JOURNAL ARTICLE
Ravneet Malhi, Gitanjali Mago, Puneet Sharma, Ramandeep Singh Gambhir, Amit Aggarwal, Anupreet Paul
BACKGROUND: Prevalence and practices of tobacco usage in India are diverse and incongruent and Government of India has enacted various laws to overcome this burden. To make tobacco control measures effective and powerful, WHO introduced MPOWER in 2004 and India was one of the first countries that implemented the MPOWER. OBJECTIVE: This study is aimed to quantify the implementation of MPOWER tobacco control policies in India. MATERIAL AND METHODS: In this retrospective analysis, data was gathered from the WHO MPOWER of India from 2015 to 2021...
2023: Roczniki Państwowego Zakładu Higieny
#24
JOURNAL ARTICLE
Duong T Nguyen, Eva Celeste Henningsen, Dave Lewis, Rohit Mago, Meredith McNeil, Radoslaw Suchecki, Scott Boden, Jana Sperschneider, Shahryar Kianian, Peter Dodds, Melania Figueroa
Puccinia coronata f. sp. avenae ( Pca ) is the causal agent of the disease known as crown rust which represents a bottleneck in oat production worldwide. Characterisation of pathogen populations often involves race (pathotype) assignments using differential sets, which are not uniform across countries. This study compared virulence profiles of 25 Pca isolates from Australia using two host differential sets, one from Australia and one from the USA. These differential sets were also genotyped using DArT sequencing technology...
December 19, 2023: Phytopathology
#25
JOURNAL ARTICLE
Neeraj Rao, Anand Agrawal, Akshay Kapoor, Vishal Mago, Madhubari Vathulya, Debarati Chattopadhyay
Background In India, between May 5 and July 2021, 41,512 cases and 3,554 deaths due to mucormycosis were reported in coronavirus disease 2019 (COVID-19)-infected patients or COVID-19-recovered patients. COVID-19-associated rhino-orbital mucormycosis (CAROM) has been associated with adverse effects that can affect oral health, vision, and physical as well as emotional functioning. After the radical debridement of CAROM and antifungal therapy, reconstructive surgery should be employed to restore function and aesthetics; however, limited clinical data exist on its potential effect on the quality of life (QOL) of these patients...
December 2023: Indian Journal of Plastic Surgery: Official Publication of the Association of Plastic Surgeons of India
#26
JOURNAL ARTICLE
Juan Luis Escobar-Ramírez, Jacinto Santiago-Mejía, Maribel Soto-Núñez, Oscar Salvador Barrera-Vázquez, Roberto Vargas-Querea, Gil Alfonso Magos-Guerrero
Chiranthodendron pentadactylon Larreat is a tree native to southeastern Mexico and Guatemala. Its flower is used in Mexican folk medicine to treat a variety of diseases, including conditions of blood pressure. However, scientific information on its usefulness in this pathology is lacking. The present study evaluates the effect of a methanolic extract (ME) from the flower and its active constituents on heart rate (HR) and mean arterial pressure (MAP) in anesthetized rats (MAPHR). The study also analyzed the effects on rat-isolated aortic rings (RIAR) and the rat mesenteric arterial bed (MABR)...
November 22, 2023: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
#27
Shingo Yoshikawa, Paul Tang, Julie H Simpson
Flies groom in response to competing mechanosensory cues in an anterior to posterior order using specific legs. From behavior screens, we identified a pair of cholinergic command-like neurons, Mago-no-Te (MGT), whose optogenetic activation elicits thoracic grooming by hind legs. Thoracic grooming is typically composed of body sweeps and leg rubs in alternation, but clonal analysis coupled with amputation experiments revealed that MGT activation only commands the body sweeps: initiation of leg rubbing requires contact between leg and thorax...
November 20, 2023: bioRxiv
#28
JOURNAL ARTICLE
Oscar Salvador Barrera-Vázquez, Sergio Andrés Montenegro-Herrera, María Elena Martínez-Enríquez, Juan Luis Escobar-Ramírez, Gil Alfonso Magos-Guerrero
Many natural products have been acquired from plants for their helpful properties. Medicinal plants are used for treating a variety of pathologies or symptoms. The axes of many pathological processes are inflammation, oxidative stress, and senescence. This work is focused on identifying Mexican medicinal plants with potential anti-oxidant, anti-inflammatory, anti-aging, and anti-senescence effects through network analysis and chemoinformatic screening of their phytochemicals. We used computational methods to analyze drug-like phytochemicals in Mexican medicinal plants, multi-target compounds, and signaling pathways related to anti-oxidant, anti-inflammatory, anti-aging, and anti-senescence mechanisms...
November 20, 2023: Biomolecules
#29
JOURNAL ARTICLE
Gergely Németh, Mánuel László Mágó, Zoltán Kaló, Judit Lám, Tamás Balogh, Valentin Brodszky
Achieving price efficiency via tenders, the sustainability of competition, and the prevention of shortages are hot topics in the debates about shaping the pharmaceutical markets. Single-winner tenders receive growing criticism for concentrating on achieving low prices at the expense of the long-term maintenance of a competitive pharmaceutical industry, the security of continuous supply, and disregarding the therapeutic needs of patient populations with specific conditions. This paper aims at drafting a concept to assist the design of multi-winner tenders for medicinal products with a focus on supply and sales guarantees, price efficiency, and equity in access...
2023: Frontiers in Medicine
#30
JOURNAL ARTICLE
Zara Shaida, Tiarnan Magos, Hala Kanona, Azhar Shaida
No abstract text is available yet for this article.
December 1, 2023: Otology & Neurotology
#31
JOURNAL ARTICLE
Axel Hochkirch, Melanie Bilz, Catarina C Ferreira, Anja Danielczak, David Allen, Ana Nieto, Carlo Rondinini, Kate Harding, Craig Hilton-Taylor, Caroline M Pollock, Mary Seddon, Jean-Christophe Vié, Keith N A Alexander, Emily Beech, Manuel Biscoito, Yoan Braud, Ian J Burfield, Filippo Maria Buzzetti, Marta Cálix, Kent E Carpenter, Ning Labbish Chao, Dragan Chobanov, Maarten J M Christenhusz, Bruce B Collette, Mia T Comeros-Raynal, Neil Cox, Matthew Craig, Annabelle Cuttelod, William R T Darwall, Benoit Dodelin, Nicholas K Dulvy, Eve Englefield, Michael F Fay, Nicholas Fettes, Jörg Freyhof, Silvia García, Mariana García Criado, Michael Harvey, Nick Hodgetts, Christina Ieronymidou, Vincent J Kalkman, Shelagh P Kell, James Kemp, Sonia Khela, Richard V Lansdown, Julia M Lawson, Danna J Leaman, Joana Magos Brehm, Nigel Maxted, Rebecca M Miller, Eike Neubert, Baudewijn Odé, David Pollard, Riley Pollom, Rob Pople, Juan José Presa Asensio, Gina M Ralph, Hassan Rankou, Malin Rivers, Stuart P M Roberts, Barry Russell, Alexander Sennikov, Fabien Soldati, Anna Staneva, Emilie Stump, Andy Symes, Dmitry Telnov, Helen Temple, Andrew Terry, Anastasiya Timoshyna, Chris van Swaay, Henry Väre, Rachel H L Walls, Luc Willemse, Brett Wilson, Jemma Window, Emma G E Wright, Thomas Zuna-Kratky
Biodiversity loss is a major global challenge and minimizing extinction rates is the goal of several multilateral environmental agreements. Policy decisions require comprehensive, spatially explicit information on species' distributions and threats. We present an analysis of the conservation status of 14,669 European terrestrial, freshwater and marine species (ca. 10% of the continental fauna and flora), including all vertebrates and selected groups of invertebrates and plants. Our results reveal that 19% of European species are threatened with extinction, with higher extinction risks for plants (27%) and invertebrates (24%) compared to vertebrates (18%)...
2023: PloS One
#32
REVIEW
Samaksh Rai, Yashika Mago, Geetika Aggarwal, Anjali Yadav, Sakshi Tewari
The human population is expanding at an exponential rate, and has created a great surge in the demand for food production. To intensify the rate of crop production, there is a tremendous usage of chemical pesticides and fertilizers. The practice of using these chemicals to enhance crop productivity has resulted in the degradation of soil fertility, leading to the depletion of native soil microflora. The constant application of these hazardous chemicals in the soil possesses major threat to humans and animals thereby impacting the agroecosystem severely...
November 4, 2023: Molecular Biotechnology
#33
JOURNAL ARTICLE
Oscar Arrieta, Laura Margarita Bolaño-Guerra, Enrique Caballé-Pérez, Luis Lara-Mejía, Jenny G Turcott, Salvador Gutiérrez, Francisco Lozano-Ruiz, Luis Cabrera-Miranda, Andrés Mauricio Arroyave-Ramírez, Federico Maldonado-Magos, Luis Corrales, Claudio Martín, Ana Pamela Gómez-García, Bernardo Cacho-Díaz, Andrés F Cardona
BACKGROUND: Different prognostic scales exist in patients with brain metastasis, particularly in lung cancer. The Graded Prognostic Assessment for lung cancer using molecular markers (Lung-molGPA index) for brain metastases is a powerful prognostic tool that effectively identifies patients at different risks. However, these scales do not include perilesional edema diameter (PED) associated with brain metastasis. Current evidence suggests that PED might compromise the delivery and efficacy of radiotherapy to treat BM...
2023: Frontiers in Oncology
#34
JOURNAL ARTICLE
Jana Sperschneider, Tim Hewitt, David C Lewis, Sambasivam Periyannan, Andrew W Milgate, Lee T Hickey, Rohit Mago, Peter N Dodds, Melania Figueroa
In clonally reproducing dikaryotic rust fungi, non-sexual processes such as somatic nuclear exchange are postulated to play a role in diversity but have been difficult to detect due to the lack of genome resolution between the two haploid nuclei. We examined three nuclear-phased genome assemblies of Puccinia triticina, which causes wheat leaf rust disease. We found that the most recently emerged Australian lineage was derived by nuclear exchange between two pre-existing lineages, which originated in Europe and North America...
October 26, 2023: Nature Microbiology
#35
JOURNAL ARTICLE
Megan K Applewhite, Jacob Mago, Wayne Shelton
AbstractInjuries from failed suicide attempts account for a large number of patients cared for in the emergency and trauma setting. While a fundamental underpinning of clinical ethics is that patients have a right to refuse treatment, individuals presenting with life-threating injuries resulting from suicide attempts are almost universally treated in this acute care setting. Here we discuss the limitations on physician ability to determine capacity in this setting and the challenges these pose in carrying out patient wishes...
2023: Journal of Clinical Ethics
#36
JOURNAL ARTICLE
Farooq Azam Rathore, Arpit Mago, Fareeha Farooq
Null.
October 2023: Journal of the College of Physicians and Surgeons—Pakistan: JCPSP
#37
JOURNAL ARTICLE
Corina Guendulain, Pablo Tamiozzo, Griselda González, Marina Caffaratti
Helicobacter es un género bacteriano gram negativo que coloniza el estómago de humanos y perros, entre otros mamíferos. En la mucosa gástrica del hombre la especie más frecuentemente hallada es H. pylori, sin embargo, puede albergar otras especies, como H. suis, H. bizzozeronii, H. felis, H. salomonis y H. heilmannii sensu stricto, denominadas Helicobacter no H. pylori (NHPH), algunas de las cuales colonizan también el estómago del perro. La detección de especies NHPH en la mucosa del estómago de seres humanos con enfermedad gástrica y en un alto porcentaje de perros como mascotas, sugiere la posibilidad de que estos animales jueguen un rol importante en la patogenia y transmisión de la infección al hombre, postulándose la vía de transmisión oral-oral o bien fecal-oral...
September 29, 2023: Revista de la Facultad de Ciencias Médicas
#38
JOURNAL ARTICLE
Aryan Mago, Yeon-Suk Yang, Jae-Hyuck Shim, Aijaz Ahmad John
Chronic exposure to low concentrations of volatile organic compounds (VOCs), such as chlorobenzene, is not being monitored in industrializing countries, although VOC exposure is associated with carcinogenic, organ-toxic, and endocrine-disrupting effects. Current VOC-sensing technologies are inaccessible due to high cost, size, and maintenance or are ineffective due to poor sensitivity or reliability. In particular, marginalized individuals face barriers to traditional prescription VOC treatments due to cost, lack of transportation, and limited access to physicians; thus, alternative treatments are needed...
September 15, 2023: Sensors
#39
REVIEW
Ashish Kothari, Radhika Kherdekar, Vishal Mago, Madhur Uniyal, Garima Mamgain, Roop Bhushan Kalia, Sandeep Kumar, Neeraj Jain, Atul Pandey, Balram Ji Omar
Antibiotic resistance in Pseudomonas aeruginosa remains one of the most challenging phenomena of everyday medical science. The universal spread of high-risk clones of multidrug-resistant/extensively drug-resistant (MDR/XDR) clinical P. aeruginosa has become a public health threat. The P. aeruginosa bacteria exhibits remarkable genome plasticity that utilizes highly acquired and intrinsic resistance mechanisms to counter most antibiotic challenges. In addition, the adaptive antibiotic resistance of P. aeruginosa , including biofilm-mediated resistance and the formation of multidrug-tolerant persisted cells, are accountable for recalcitrance and relapse of infections...
August 30, 2023: Pharmaceuticals
#40
JOURNAL ARTICLE
Paul Hutchinson, Rose Zulliger, Jessica K Butts, Balthazar Candrinho, Abu Saifodine, Thomas P Eisele, Josh Yukich
BACKGROUND: Malaria is endemic throughout Mozambique, contributing significantly to the country's burden of disease. Prompt and effective treatment for fevers in children can limit the mortality and morbidity impacts of the disease but many children in the country are not taken for formal care when ill. Using an ideational model of behaviour, this study assesses the magnitude of the relationships for potential drivers of care-seeking, including interpersonal communication, malaria messaging, and knowledge and attitudes about malaria, with actual care-seeking behaviours for under-five children with fever in Magoé district, Mozambique...
September 21, 2023: Malaria Journal
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