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https://www.readbyqxmd.com/read/28894625/exploratory-studies-of-some-mexican-medicinal-plants-cardiovascular-effects-in-rats-with-and-without-hypertension
#1
Gil Alfonso Magos-Guerrero, Jacinto Santiago-Mejía, Omar F Carrasco
BACKGROUND: Papaveraceae Argemone mexicana L., Burseraceae Bursera simaruba (L.) Sarg., Acanthaceae Justicia spicigera Schltdl. and Selaginellaceae Selaginella lepidophylla (Hook. & Grev.) Spring., have been used in Mexican traditional medicine to treat hypertension. The objective of this study was to further characterize the cardiovascular effects of the methanol extracts of such plants. METHODS: The medicinal plants were collected and taxonomically identified; the methanol extract of each explored plant were administrated to conscious and unconscious male Wistar rats with and without glucose-induced hypertension...
July 2017: Journal of Intercultural Ethnopharmacology
https://www.readbyqxmd.com/read/28857719/a-randomized-double-blind-placebo-controlled-dose-ranging-study-of-lisdexamfetamine-dimesylate-augmentation-for-major-depressive-disorder-in-adults-with-inadequate-response-to-antidepressant-therapy
#2
Cynthia Richards, Dan V Iosifescu, Rajnish Mago, Elias Sarkis, James Reynolds, Brooke Geibel, Matthew Dauphin
BACKGROUND: This randomized, double-blind, placebo-controlled study evaluated dose-response relationships of lisdexamfetamine dimesylate when used as augmentation for major depressive disorder in individuals exhibiting inadequate responses to antidepressant monotherapy. METHODS: Eligible adults (18-65 years) were assigned to antidepressant monotherapy (escitalopram or venlafaxine extended-release) plus lisdexamfetamine dimesylate-matching placebo during an eight-week single-blind lead-in phase...
August 1, 2017: Journal of Psychopharmacology
https://www.readbyqxmd.com/read/28856652/generation-of-loss-of-function-mutants-for-wheat-rust-disease-resistance-gene-cloning
#3
Rohit Mago, Bradley Till, Sambasivam Periyannan, Guotai Yu, Brande B H Wulff, Evans Lagudah
One of the most important tools to identify and validate rust resistance gene function is by producing loss-of-function mutants. Mutants can be produced using irradiation, chemicals, and insertions. Among all the mutagens, ethyl methanesulfonate (EMS) and sodium azide are most favored because of the ease of use and generation of random point mutations in the genome. The mutants so produced facilitate the isolation, identification and cloning of rust resistance genes. In this chapter we describe a protocol for seed mutagenesis of wheat with EMS and sodium azide...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28716280/association-of-polymorphisms-and-reduced-expression-levels-of-the-nr4a2-gene-with-parkinson-s-disease-in-a-mexican-population
#4
Elizabeth Ruiz-Sánchez, Petra Yescas, Mayela Rodríguez-Violante, Nancy Martínez-Rodríguez, Jesica N Díaz-López, Adriana Ochoa, Sergio S Valdes-Rojas, Daniel Magos-Rodríguez, Julio C Rojas-Castañeda, Amin Cervantes-Arriaga, Samuel Canizales-Quinteros, Patricia Rojas
INTRODUCTION: The NR4A2 transcription factor is important in the development, survival and phenotype of dopaminergic neurons and it is postulated as a possible biomarker for Parkinson's disease (PD). Therefore, our aim was to analyze in a sample of a Mexican population with idiopathic PD, mutations (in two hotspot mutation regions) and two polymorphisms (rs34884856 in promotor and rs35479735 intronic regions) of the NR4A2 gene. We also evaluate the levels of NR4A2 gene expression in peripheral blood for a Mexican population, and identify whether they are associated with NR4A2 gene polymorphisms...
August 15, 2017: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/28708139/geometric-phase-morphology-of-jones-matrices
#5
Dorilian Lopez-Mago, Arturo Canales-Benavides, Raul I Hernandez-Aranda, Julio C Gutiérrez-Vega
We demonstrate an innovative technique based on the Pancharatnam-Berry phase that can be used to determine whether an optical system characterized by a Jones matrix is homogeneous or inhomogeneous, containing orthogonal or nonorthogonal eigenpolarizations, respectively. Homogeneous systems have a symmetric geometric phase morphology showing line dislocations and sets of polarization states with an equal geometric phase. In contrast, the morphology of inhomogeneous systems exhibits phase singularities, where the Pancharatnam-Berry phase is undetermined...
July 15, 2017: Optics Letters
https://www.readbyqxmd.com/read/28637711/the-exon-junction-complex-and-srp54-contribute-to-hedgehog-signaling-via-ci-rna-splicing-in-drosophila-melanogaster
#6
Elisa Garcia-Garcia, Jamie C Little, Daniel Kalderon
Hedgehog (Hh) regulates the Cubitus interruptus (Ci) transcription factor in Drosophila melanogaster by activating full-length Ci-155 and blocking processing to the Ci-75 repressor. However, the interplay between the regulation of Ci-155 levels and activity, as well as processing-independent mechanisms that affect Ci-155 levels, have not been explored extensively. Here, we identified Mago Nashi (Mago) and Y14 core Exon Junction Complex (EJC) proteins, as well as the Srp54 splicing factor, as modifiers of Hh pathway activity under sensitized conditions...
August 2017: Genetics
https://www.readbyqxmd.com/read/28566540/the-exon-junction-complex-senses-energetic-stress-and-regulates-contractility-and-cell-architecture-in-cardiac-myocytes
#7
Olivier A Pierrat, Anju Paudyal, James Woodruff, Olga Koroleva, Samuel Boateng
The Exon Junction Complex (EJC) is the main mechanism by which cells select specific mRNAs for translation into protein. We hypothesised that the EJC is involved in the regulation of gene expression during the stress response in cardiac myocytes, with implications for the failing heart. In cultured rat neonatal myocytes, we examined the cellular distribution of two EJC components eIF4A3 and mago nashi homologue (Mago) in response to metabolic stress. There was significant relocalisation of eIF4A3 and Mago from the nucleus to cytoplasm following 18 hours of hypoxia...
May 31, 2017: Bioscience Reports
https://www.readbyqxmd.com/read/28402567/nonsense-mediated-mrna-decay-in-tetrahymena-is-ejc-independent-and-requires-a-protozoa-specific-nuclease
#8
Miao Tian, Wentao Yang, Jing Zhang, Huai Dang, Xingyi Lu, Chengjie Fu, Wei Miao
Nonsense-mediated mRNA decay (NMD) is essential for removing premature termination codon-containing transcripts from cells. Studying the NMD pathway in model organisms can help to elucidate the NMD mechanism in humans and improve our understanding of how this biologically important process has evolved. Ciliates are among the earliest branching eukaryotes; their NMD mechanism is poorly understood and may be primordial. We demonstrate that highly conserved Upf proteins (Upf1a, Upf2 and Upf3) are involved in the NMD pathway of the ciliate, Tetrahymena thermophila...
June 20, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/28399169/a-photoperiod-responsive-protein-compendium-and-conceptual-proteome-roadmap-outline-in-maize-grown-in-growth-chambers-with-controlled-conditions
#9
You-Zhi Li, Xian-Wei Fan, Qiang Chen, Hao Zhong
Maize (Zea mays L.) is one of the major staple food crops of the world. However, high photoperiod sensitivity, especially for tropical germplasms, impedes attempts to improve maize agronomical traits by integration of tropical and temperate maize germplasms. Physiological and phenotypic responses of maize to photoperiod have widely been investigated based on multi-site field observations; however, proteome-based responsive mechanisms under controlled photoperiod regimes, nutrient and moisture soils are not yet well understood...
2017: PloS One
https://www.readbyqxmd.com/read/28215020/climate-change-and-national-crop-wild-relative-conservation-planning
#10
Jade Phillips, Joana Magos Brehm, Bob van Oort, Åsmund Asdal, Morten Rasmussen, Nigel Maxted
Climate change is likely to be one of the most important factors affecting our future food security. To mitigate negative impacts, we will require our crops to be more genetically diverse. Such diversity is available in crop wild relatives (CWRs), the wild taxa relatively closely related to crops and from which diverse traits can be transferred to the crop. Conservation of such genetic resources resides within the nation where they are found; therefore, national-level conservation recommendations are fundamental to global food security...
February 18, 2017: Ambio
https://www.readbyqxmd.com/read/28127157/comparative-evaluation-of-bioactive-synthetic-novabone-putty-and-calcified-algae-derived-porous-hydroxyapatite-bone-grafts-for-the-treatment-of-intrabony-defects
#11
Nitika N Bembi, Sumit Bembi, Jyoti Mago, Gurpreet Kaur Baweja, Parvinder Singh Baweja
INTRODUCTION: To compare and evaluate clinically and radio-graphically the bone regeneration and the amount of bone fill in intrabony component of periodontal osseous defects through the osteoconductive and osteostimulative effect of bioactive synthetic NovaBone Putty - CMF and osteoconductive effect of calcified algae-derived porous hydroxyapatite Frios(®) Algi-pore(®) bone grafts. MATERIALS AND METHODS: Twenty-two sites in 11 patients, within the age range of 25 to 60 years, showing intrabony defects were selected according to split mouth design and divided into group I (Frios(®) Algipore(®)) and group II (NovaBone Putty - CMF)...
October 2016: International Journal of Clinical Pediatric Dentistry
https://www.readbyqxmd.com/read/28125819/advanced-squamous-cell-carcinoma-of-the-head-and-neck-the-current-role-of-cetuximab
#12
Martín Granados-García, José Luis Aguilar-Ponce, Federico Maldonado-Magos, Jaime G De la Garza-Salazar
We review clinical trials of squamous cell carcinoma of the head and neck (SCCHN) to address the current and potential uses of cetuximab (CTX). PubMed was reviewed to identify papers published between 2010 and 2016. The search terms used were "cetuximab" and "head and neck cancer." A total of 634 articles were identified. Phase II or III studies with CTX in patients with advanced SCCHN without treatment or with recurrent/metastatic tumors were selected. Forty-six registries were obtained. Information was critically reviewed and relevant information presented...
2016: ORL; Journal for Oto-rhino-laryngology and its related Specialties
https://www.readbyqxmd.com/read/27879206/exon-junction-complex-proteins-bind-nascent-transcripts-independently-of-pre-mrna-splicing-in-drosophila-melanogaster
#13
Subhendu Roy Choudhury, Anand K Singh, Tina McLeod, Marco Blanchette, Boyun Jang, Paul Badenhorst, Aditi Kanhere, Saverio Brogna
Although it is currently understood that the exon junction complex (EJC) is recruited on spliced mRNA by a specific interaction between its central protein, eIF4AIII, and splicing factor CWC22, we found that eIF4AIII and the other EJC core proteins Y14 and MAGO bind the nascent transcripts of not only intron-containing but also intronless genes on Drosophila polytene chromosomes. Additionally, Y14 ChIP-seq demonstrates that association with transcribed genes is also splicing-independent in Drosophila S2 cells...
November 23, 2016: ELife
https://www.readbyqxmd.com/read/27717211/offers-of-appointments-with-nurse-practitioners-if-a-requested-physician-is-unavailable
#14
Sarah Tinkler, Rajiv Sharma, Sudeshna Pal, Raven Susu-Mago, Miron Stano
BACKGROUND AND PURPOSE: Access to primary care remains a problem for a substantial portion of the U.S. population, and is predicted to worsen due to an aging population and the increasing burden of chronic diseases. Better integration of nurse practitioners (NPs) into the primary care workforce is a possible solution. We examine offers of appointments with NPs if a requested primary care physician is unavailable. METHODS: Data are from a 2013 audit (simulated patient) study requesting appointment information from a national random sample of primary care physicians...
April 2017: Journal of the American Association of Nurse Practitioners
https://www.readbyqxmd.com/read/27708031/plant-diversity-patterns-in-neotropical-dry-forests-and-their-conservation-implications
#15
Karina Banda-R, Alfonso Delgado-Salinas, Kyle G Dexter, Reynaldo Linares-Palomino, Ary Oliveira-Filho, Darién Prado, Martin Pullan, Catalina Quintana, Ricarda Riina, Gina M Rodríguez M, Julia Weintritt, Pedro Acevedo-Rodríguez, Juan Adarve, Esteban Álvarez, Anairamiz Aranguren B, Julián Camilo Arteaga, Gerardo Aymard, Alejandro Castaño, Natalia Ceballos-Mago, Álvaro Cogollo, Hermes Cuadros, Freddy Delgado, Wilson Devia, Hilda Dueñas, Laurie Fajardo, Ángel Fernández, Miller Ángel Fernández, Janet Franklin, Ethan H Freid, Luciano A Galetti, Reina Gonto, Roy González-M, Roger Graveson, Eileen H Helmer, Álvaro Idárraga, René López, Humfredo Marcano-Vega, Olga G Martínez, Hernán M Maturo, Morag McDonald, Kurt McLaren, Omar Melo, Francisco Mijares, Virginia Mogni, Diego Molina, Natalia Del Pilar Moreno, Jafet M Nassar, Danilo M Neves, Luis J Oakley, Michael Oatham, Alma Rosa Olvera-Luna, Flávia F Pezzini, Orlando Joel Reyes Dominguez, María Elvira Ríos, Orlando Rivera, Nelly Rodríguez, Alicia Rojas, Tiina Särkinen, Roberto Sánchez, Melvin Smith, Carlos Vargas, Boris Villanueva, R Toby Pennington
Seasonally dry tropical forests are distributed across Latin America and the Caribbean and are highly threatened, with less than 10% of their original extent remaining in many countries. Using 835 inventories covering 4660 species of woody plants, we show marked floristic turnover among inventories and regions, which may be higher than in other neotropical biomes, such as savanna. Such high floristic turnover indicates that numerous conservation areas across many countries will be needed to protect the full diversity of tropical dry forests...
September 23, 2016: Science
https://www.readbyqxmd.com/read/27686310/research-productivity-of-gulf-cooperation-council-gcc-countries-in-science-and-social-sciences
#16
Sultan Ayoub Meo, Abdul Latif Mahesar, Saeed Ahmed Sheikh, Kamran Sattar, Ishfaq A Bukhari
OBJECTIVE: To investigate the research progress of Gulf Cooperation Council countries in science and social sciences. METHODS: This study was conducted in the Department of Physiology, College of Medicine, King Saud University, Riyadh, Saudi Arabia, from June 2014 to February 2015.All research documents related to the 1996-2013 period having an affiliation with Gulf Cooperation Council countries, including Saudi Arabia, the United Arab Emirates, Kuwait, Qatar, Bahrain and Oman, were tracked...
October 2016: JPMA. the Journal of the Pakistan Medical Association
https://www.readbyqxmd.com/read/27617937/recurrent-adult-onset-henoch-schonlein-purpura-a-case-report
#17
Neil Gaskill, Bruce Guido, Cynthia Magro
Henoch-Schonlein purpura is an immunoglobulin A (IgA)-immune complex mediated leukocytoclastic vasculitis that classically manifests with palpable purpura, abdominal pain, arthritis, and hematuria or proteinuria. The condition is much more predominant in children (90% of cases) and commonly follows an upper respiratory infection. We present a case of recurrent Henoch-Schonlein purpura (HSP) complicated by nephritis in an adult female initially categorized as IgA nephropathy (IgAN). We review the pathophysiologic basis of HSP nephritis as the variant of HSP accompanied by renal involvement and its pathogenetic commonality with IgA nephropathy...
August 15, 2016: Dermatology Online Journal
https://www.readbyqxmd.com/read/27555587/cytosolic-activation-of-cell-death-and-stem-rust-resistance-by-cereal-mla-family-cc-nlr-proteins
#18
Stella Cesari, John Moore, Chunhong Chen, Daryl Webb, Sambasivam Periyannan, Rohit Mago, Maud Bernoux, Evans S Lagudah, Peter N Dodds
Plants possess intracellular immune receptors designated "nucleotide-binding domain and leucine-rich repeat" (NLR) proteins that translate pathogen-specific recognition into disease-resistance signaling. The wheat immune receptors Sr33 and Sr50 belong to the class of coiled-coil (CC) NLRs. They confer resistance against a broad spectrum of field isolates of Puccinia graminis f. sp. tritici, including the Ug99 lineage, and are homologs of the barley powdery mildew-resistance protein MLA10. Here, we show that, similarly to MLA10, the Sr33 and Sr50 CC domains are sufficient to induce cell death in Nicotiana benthamiana Autoactive CC domains and full-length Sr33 and Sr50 proteins self-associate in planta In contrast, truncated CC domains equivalent in size to an MLA10 fragment for which a crystal structure was previously determined fail to induce cell death and do not self-associate...
September 6, 2016: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/27517068/economic-effects-of-anti-depressant-usage-on-elective-lumbar-fusion-surgery
#19
Amirali Sayadipour, Chrisopher K Kepler, Rajnish Mago, Kenneth M Certa, Mohammad R Rasouli, Alexander R Vaccaro, Todd J Albert, David G Anderson
BACKGROUND: It has been suggested, although not proven, that presence of concomitant psychiatric disorders may increase the inpatient costs for patients undergoing elective surgery. This study was designed to test the hypothesis that elective lumbar fusion surgery is more costly in patients with under treatment for depression. METHODS: This is a retrospective case-control study of 142 patients who underwent elective lumbar fusion. Of those 142 patients, 41 patients were chronically using an antidepressant medication that considered as a "study group", and 101 patients were not taking an antidepressant medication that considered as a "control group"...
June 2016: Archives of Bone and Joint Surgery
https://www.readbyqxmd.com/read/27514304/the-neglected-side-of-suffering
#20
EDITORIAL
Rajnish Mago
No abstract text is available yet for this article.
September 2016: Psychiatric Clinics of North America
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