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https://www.readbyqxmd.com/read/29780430/healthcare-professionals-perceptions-on-the-emotional-impact-of-having-an-inadequate-response-to-antidepressant-medications-survey-and-prospective-patient-audit
#1
Rajnish Mago, Andrea Fagiolini, Emmanuelle Weiller, Catherine Weiss
Background: Despite the availability of effective antidepressants, about half of patients with major depressive disorder (MDD) display an inadequate response to their initial treatment. A large patient survey recently reported that 29.8% of MDD patients experiencing an inadequate treatment response felt frustrated about their medication and 19.2% were frustrated with their healthcare provider. This survey and chart audit evaluated healthcare professionals' (HCP) views on the emotional impact of having an inadequate response to antidepressant medication...
2018: Annals of General Psychiatry
https://www.readbyqxmd.com/read/29719220/access-to-us-primary-care-physicians-for-new-patients-concerned-about-smoking-or-weight
#2
Sarah E Tinkler, Rajiv L Sharma, Raven R H Susu-Mago, Sudeshna Pal, Miron Stano
Tobacco smoking and obesity are leading causes of preventable morbidity and mortality in the US, and primary care physicians are the main source of preventive care. However, it is not known whether access for new patients is affected by an expression of interest in preventive care. In a 2015 audit, we called US primary care physicians' offices to request appointment information regarding new patient physicals for simulated patients. Simulated patients were differentiated by smoking concerns (N = 907), weight concerns (N = 867), or no health concerns ("healthy" patients; N = 3561)...
April 29, 2018: Preventive Medicine
https://www.readbyqxmd.com/read/29666159/extensive-identification-and-in-depth-validation-of-importin-13-cargoes
#3
Imke Baade, Christiane Spillner, Kerstin Schmitt, Oliver Valerius, Ralph H Kehlenbach
Importin 13 is a member of the importin b family of transport receptors. Unlike most family members, importin 13 mediates both, nuclear protein import and export. To search for novel importin 13 cargoes, we used stable isotope labeling of amino acids in cell culture (SILAC) and mass spectrometry. Using stringent criteria, we identified 255 importin 13 substrates, including the known cargoes Ubc9, Mago and eIF1A, and validate many of them as transport cargoes by extensive biochemical and cell biological characterization...
April 17, 2018: Molecular & Cellular Proteomics: MCP
https://www.readbyqxmd.com/read/29653229/the-splicing-of-tiny-introns-of-paramecium-is-controlled-by-mago
#4
Julia Contreras, Victoria Begley, Laura Marsella, Eduardo Villalobo
The exon junction complex (EJC) is a key element of the splicing machinery. The EJC core is composed of eIF4A3, MAGO, Y14 and MLN51. Few accessory proteins, such as CWC22 or UPF3, bind transiently to the EJC. The EJC has been implicated in the control of the splicing of long introns. To ascertain whether the EJC controls the splicing of short introns, we used Paramecium tetraurelia as a model organism, since it has thousands of very tiny introns. To elucidate whether EJC affects intron splicing in P. tetraurelia, we searched for EJC protein-coding genes, and silenced those genes coding for eIF4A3, MAGO and CWC22...
April 10, 2018: Gene
https://www.readbyqxmd.com/read/29446849/anxiety-and-anger-of-homeless-people-coping-with-dental-care
#5
Anjali Mago, Michael I MacEntee, Mario Brondani, James Frankish
OBJECTIVES: To reveal and describe from open-ended interviews how homeless people in Vancouver interpret, appraise and cope with dental care. METHODS: Audio-recorded interviews with 25 homeless people (18 men and 7 women; age range: 25-64 years), purposefully selected for a range of experiences, were transcribed and analysed inductively. The process of interpretive description drawing from the Behavioral Model for Vulnerable Populations and Lazarus's Theory of Emotions identified how participants appraised and coped with dental care...
February 15, 2018: Community Dentistry and Oral Epidemiology
https://www.readbyqxmd.com/read/29402325/understanding-the-emotions-of-patients-with-inadequate-response-to-antidepressant-treatments-results-of-an-international-online-survey-in-patients-with-major-depressive-disorder
#6
Rajnish Mago, Andrea Fagiolini, Emmanuelle Weiller, Catherine Weiss
BACKGROUND: Evidence suggests that nearly half of patients with major depressive disorder (MDD) do not achieve an adequate response to antidepressant treatments (ADTs), which impacts patients' functioning, quality of life (QoL), and well-being. This patient survey aimed to better understand patient perspectives on the emotional impact of experiencing an inadequate response to ADTs. METHODS: An online survey was conducted in 6 countries with respondents diagnosed with MDD and experiencing an inadequate response to ADTs...
February 5, 2018: BMC Psychiatry
https://www.readbyqxmd.com/read/29242458/on-four-new-species-of-the-jumping-spider-genus-i-mago-i-o-pickard-cambridge-1882-from-south-america-araneae-salticidae
#7
Erika L S Costa, Gustavo R S Ruiz
Four new species of Mago O. Pickard-Cambridge, 1882 are described. Mago furcatus sp. nov. and Mago mimicus sp. nov. are described from Ecuador (Orellana and Napo provinces, respectively), both based only on the male holotypes. Both sexes of Mago pardo sp. nov. and the male of Mago apophysis sp. nov. are also described from the state of Pará, Brazil. A map with records of these species is given.
October 10, 2017: Zootaxa
https://www.readbyqxmd.com/read/29080146/use-of-narrow-band-imaging-and-4k-technology-in-otology-and-neuro-otology-preliminary-experience-and-feasibility-study
#8
Henry Zhang, Phui Yee Wong, Tiarnan Magos, Jabin Thaj, Gaurav Kumar
The advent of the endoscope has facilitated otological surgery in recent years. Advances in optical technology have led to the development of high definition visualisation, such as 4K magnification. Narrow band imaging (NBI) has been shown to improve visualisation of tissue based on varying degrees of vascularity. This is a feasibility study, the first of its kind, aiming to investigate the appearances of middle ear anatomy and pathology (tympanic membrane, tympanosclerosis, cholesteatoma, granulation, endolymphatic sac hydrops, otosclerosis) under the NBI filter, using a high definition 4K endoscope...
January 2018: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/29078215/-side-effects-of-psychotropic-medication-suggestions-for-clinical-practice
#9
REVIEW
Anna Grunze, Rajnish Mago, Heinz Grunze
Psychotropics are highly effective medications that, however, have adverse drug reactions attached to them. They are indispensable for many patients. How to cope with side effects - watchful waiting, dose reduction, change of medication, addition of an "antidote" and behavioural modifications - depends on their nature, severity and finally the patients wish. This review is meant to aid clinician's and patient's decisions in case of the occurrence of compromising, frequent adverse drug reactions.
November 2017: Deutsche Medizinische Wochenschrift
https://www.readbyqxmd.com/read/28944526/state-medicaid-fees-and-access-to-primary-care-physicians
#10
Rajiv Sharma, Sarah Tinkler, Arnab Mitra, Sudeshna Pal, Raven Susu-Mago, Miron Stano
Medicaid and uninsured patients are disadvantaged in access to care and are disproportionately Black and Hispanic. Using a national audit of primary care physicians, we examine the relationship between state Medicaid fees for primary care services and access for Medicaid, Medicare, uninsured, and privately insured patients who differ by race/ethnicity and sex. We found that states with higher Medicaid fees had higher probabilities of appointment offers and shorter wait times for Medicaid patients, and lower probabilities of appointment offers and longer wait times for uninsured patients...
September 24, 2017: Health Economics
https://www.readbyqxmd.com/read/28894625/exploratory-studies-of-some-mexican-medicinal-plants-cardiovascular-effects-in-rats-with-and-without-hypertension
#11
Gil Alfonso Magos-Guerrero, Jacinto Santiago-Mejía, Omar F Carrasco
BACKGROUND: Papaveraceae Argemone mexicana L., Burseraceae Bursera simaruba (L.) Sarg ., Acanthaceae Justicia spicigera Schltdl . and Selaginellaceae Selaginella lepidophylla (Hook. & Grev.) Spring., have been used in Mexican traditional medicine to treat hypertension. The objective of this study was to further characterize the cardiovascular effects of the methanol extracts of such plants. METHODS: The medicinal plants were collected and taxonomically identified; the methanol extract of each explored plant were administrated to conscious and unconscious male Wistar rats with and without glucose-induced hypertension...
July 2017: Journal of Intercultural Ethnopharmacology
https://www.readbyqxmd.com/read/28857719/a-randomized-double-blind-placebo-controlled-dose-ranging-study-of-lisdexamfetamine-dimesylate-augmentation-for-major-depressive-disorder-in-adults-with-inadequate-response-to-antidepressant-therapy
#12
Cynthia Richards, Dan V Iosifescu, Rajnish Mago, Elias Sarkis, James Reynolds, Brooke Geibel, Matthew Dauphin
BACKGROUND: This randomized, double-blind, placebo-controlled study evaluated dose-response relationships of lisdexamfetamine dimesylate when used as augmentation for major depressive disorder in individuals exhibiting inadequate responses to antidepressant monotherapy. METHODS: Eligible adults (18-65 years) were assigned to antidepressant monotherapy (escitalopram or venlafaxine extended-release) plus lisdexamfetamine dimesylate-matching placebo during an eight-week single-blind lead-in phase...
September 2017: Journal of Psychopharmacology
https://www.readbyqxmd.com/read/28856652/generation-of-loss-of-function-mutants-for-wheat-rust-disease-resistance-gene-cloning
#13
Rohit Mago, Bradley Till, Sambasivam Periyannan, Guotai Yu, Brande B H Wulff, Evans Lagudah
One of the most important tools to identify and validate rust resistance gene function is by producing loss-of-function mutants. Mutants can be produced using irradiation, chemicals, and insertions. Among all the mutagens, ethyl methanesulfonate (EMS) and sodium azide are most favored because of the ease of use and generation of random point mutations in the genome. The mutants so produced facilitate the isolation, identification and cloning of rust resistance genes. In this chapter we describe a protocol for seed mutagenesis of wheat with EMS and sodium azide...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28716280/association-of-polymorphisms-and-reduced-expression-levels-of-the-nr4a2-gene-with-parkinson-s-disease-in-a-mexican-population
#14
Elizabeth Ruiz-Sánchez, Petra Yescas, Mayela Rodríguez-Violante, Nancy Martínez-Rodríguez, Jesica N Díaz-López, Adriana Ochoa, Sergio S Valdes-Rojas, Daniel Magos-Rodríguez, Julio C Rojas-Castañeda, Amin Cervantes-Arriaga, Samuel Canizales-Quinteros, Patricia Rojas
INTRODUCTION: The NR4A2 transcription factor is important in the development, survival and phenotype of dopaminergic neurons and it is postulated as a possible biomarker for Parkinson's disease (PD). Therefore, our aim was to analyze in a sample of a Mexican population with idiopathic PD, mutations (in two hotspot mutation regions) and two polymorphisms (rs34884856 in promotor and rs35479735 intronic regions) of the NR4A2 gene. We also evaluate the levels of NR4A2 gene expression in peripheral blood for a Mexican population, and identify whether they are associated with NR4A2 gene polymorphisms...
August 15, 2017: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/28708139/geometric-phase-morphology-of-jones-matrices
#15
Dorilian Lopez-Mago, Arturo Canales-Benavides, Raul I Hernandez-Aranda, Julio C Gutiérrez-Vega
We demonstrate an innovative technique based on the Pancharatnam-Berry phase that can be used to determine whether an optical system characterized by a Jones matrix is homogeneous or inhomogeneous, containing orthogonal or nonorthogonal eigenpolarizations, respectively. Homogeneous systems have a symmetric geometric phase morphology showing line dislocations and sets of polarization states with an equal geometric phase. In contrast, the morphology of inhomogeneous systems exhibits phase singularities, where the Pancharatnam-Berry phase is undetermined...
July 15, 2017: Optics Letters
https://www.readbyqxmd.com/read/28637711/the-exon-junction-complex-and-srp54-contribute-to-hedgehog-signaling-via-ci-rna-splicing-in-drosophila-melanogaster
#16
Elisa Garcia-Garcia, Jamie C Little, Daniel Kalderon
Hedgehog (Hh) regulates the Cubitus interruptus (Ci) transcription factor in Drosophila melanogaster by activating full-length Ci-155 and blocking processing to the Ci-75 repressor. However, the interplay between the regulation of Ci-155 levels and activity, as well as processing-independent mechanisms that affect Ci-155 levels, have not been explored extensively. Here, we identified Mago Nashi (Mago) and Y14 core Exon Junction Complex (EJC) proteins, as well as the Srp54 splicing factor, as modifiers of Hh pathway activity under sensitized conditions...
August 2017: Genetics
https://www.readbyqxmd.com/read/28566540/the-exon-junction-complex-senses-energetic-stress-and-regulates-contractility-and-cell-architecture-in-cardiac-myocytes
#17
Olivier A Pierrat, Anju Paudyal, James Woodruff, Olga Koroleva, Samuel Y Boateng
The exon junction complex (EJC) is the main mechanism by which cells select specific mRNAs for translation into protein. We hypothesized that the EJC is involved in the regulation of gene expression during the stress response in cardiac myocytes, with implications for the failing heart. In cultured rat neonatal myocytes, we examined the cellular distribution of two EJC components eukaryotic translation initiation factor 4A isoform 3 (eIF4A3) and mago nashi homologue (Mago) in response to metabolic stress. There was significant relocalization of eIF4A3 and Mago from the nucleus to cytoplasm following 18 h of hypoxia...
August 31, 2017: Bioscience Reports
https://www.readbyqxmd.com/read/28402567/nonsense-mediated-mrna-decay-in-tetrahymena-is-ejc-independent-and-requires-a-protozoa-specific-nuclease
#18
Miao Tian, Wentao Yang, Jing Zhang, Huai Dang, Xingyi Lu, Chengjie Fu, Wei Miao
Nonsense-mediated mRNA decay (NMD) is essential for removing premature termination codon-containing transcripts from cells. Studying the NMD pathway in model organisms can help to elucidate the NMD mechanism in humans and improve our understanding of how this biologically important process has evolved. Ciliates are among the earliest branching eukaryotes; their NMD mechanism is poorly understood and may be primordial. We demonstrate that highly conserved Upf proteins (Upf1a, Upf2 and Upf3) are involved in the NMD pathway of the ciliate, Tetrahymena thermophila...
June 20, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/28399169/a-photoperiod-responsive-protein-compendium-and-conceptual-proteome-roadmap-outline-in-maize-grown-in-growth-chambers-with-controlled-conditions
#19
You-Zhi Li, Xian-Wei Fan, Qiang Chen, Hao Zhong
Maize (Zea mays L.) is one of the major staple food crops of the world. However, high photoperiod sensitivity, especially for tropical germplasms, impedes attempts to improve maize agronomical traits by integration of tropical and temperate maize germplasms. Physiological and phenotypic responses of maize to photoperiod have widely been investigated based on multi-site field observations; however, proteome-based responsive mechanisms under controlled photoperiod regimes, nutrient and moisture soils are not yet well understood...
2017: PloS One
https://www.readbyqxmd.com/read/28215020/climate-change-and-national-crop-wild-relative-conservation-planning
#20
Jade Phillips, Joana Magos Brehm, Bob van Oort, Åsmund Asdal, Morten Rasmussen, Nigel Maxted
Climate change is likely to be one of the most important factors affecting our future food security. To mitigate negative impacts, we will require our crops to be more genetically diverse. Such diversity is available in crop wild relatives (CWRs), the wild taxa relatively closely related to crops and from which diverse traits can be transferred to the crop. Conservation of such genetic resources resides within the nation where they are found; therefore, national-level conservation recommendations are fundamental to global food security...
October 2017: Ambio
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