Endre Nemeth, Adam Soltesz, Eniko Kovacs, Zsofia Szakal-Toth, Eszter Tamaska, Hajna Katona, Kristof Racz, Gergely Csikos, Viktor Berzsenyi, Szabolcs Fabry, Zsuzsanna Ulakcsai, Csilla Tamas, Beata Nagy, Marina Varga, Bela Merkely
AIMS: The aim of this trial was to compare the clinical effects of intraoperative haemoadsorption versus standard care in patients undergoing orthotopic heart transplantation (OHT). METHODS AND RESULTS: In a randomized, controlled trial, OHT recipients were randomized to receive intraoperative haemoadsorption or standard care. Outcomes were vasoactive-inotropic score (VIS), frequency of vasoplegic syndrome (VS) in the first 24 h; post-operative change in procalcitonin (PCT) and C-reactive protein (CRP) levels; intraoperative change in mycophenolic acid (MPA) concentration; frequency of post-operative organ dysfunction, major complications, adverse immunological events and length of in-hospital stay and 1-year survival...
December 19, 2023: ESC Heart Failure