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https://www.readbyqxmd.com/read/27860331/extracellular-matrix-metalloproteinase-inducer-emmprin-is-a-potential-biomarker-of-angiogenesis-in-proliferative-diabetic-retinopathy
#1
Ahmed M Abu El-Asrar, Ajmal Ahmad, Kaiser Alam, Mohammad Mairaj Siddiquei, Ghulam Mohammad, Gert De Hertogh, Ahmed Mousa, Ghislain Opdenakker
PURPOSE: Extracellular matrix metalloproteinase inducer (EMMPRIN) promotes angiogenesis through matrix metalloproteinases (MMPs) and vascular endothelial growth factor (VEGF) production. We investigated the expression levels of EMMPRIN and correlated these levels with VEGF, MMP-1 and MMP-9 in proliferative diabetic retinopathy (PDR). In addition, we examined the expression of EMMPRIN in the retinas of diabetic rats and the effect of EMMPRIN on the induction of angiogenesis regulatory factors in human retinal microvascular endothelial cells (HRMECs)...
November 18, 2016: Acta Ophthalmologica
https://www.readbyqxmd.com/read/27832636/inhibition-of-emmprin-and-mmp-9-expression-by-epigallocatechin-3-gallate-through-67-kda-laminin-receptor-in-pma-induced-macrophages
#2
Qi-Ming Wang, Hao Wang, Ya-Fei Li, Zhi-Yong Xie, Yao Ma, Jian-Jun Yan, Yi Fan Wei Gao, Ze-Mu Wang, Lian-Sheng Wang
BACKGROUND/AIMS: It is well documented that overexpression of EMMPRIN (extracellular matrix metalloproteinase inducer) and MMPs (matrix metalloproteinases) by monocytes/macrophages plays an important role in atherosclerotic plaque rupture. Green tea polyphenol epigallocatechin-3-gallate (EGCG) has a variety of pharmacological properties and exerts cardiovascular protective effects. Recently, the 67-kD laminin receptor (67LR) has been identified as a cell surface receptor of EGCG. The aim of the present study was to evaluate the effects of EGCG on the expression of EMMPRIN and MMP-9 in PMA-induced macrophages, and the potential mechanisms underlying its effects...
2016: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/27825419/biological-characteristics-of-cluster-of-differentiation-147-and-its-relationship-with-tumour
#3
Cen Gao, Chao-Hui Lu, Jie Chen
Cluster of differentiation 147(CD147)/extracellular matrix metalloproteinase inducer (EMMPRIN) is a widely distributed transmembrane glycoprotein that belongs to the immunoglobulin superfamily and is highly enriched on the surface of malignant tumour cells. A major function of CD147 is to stimulate matrix metalloproteinase production in stromal fibroblasts and endothelial cells. CD147 promotes growth,invasion,metastasis,and glycolysis of malignant cells,induces angiogenesis,multidrug resistance,and anoikis resistance,and inhibits starvation-induced autophagy et al...
October 10, 2016: Zhongguo Yi Xue Ke Xue Yuan Xue Bao. Acta Academiae Medicinae Sinicae
https://www.readbyqxmd.com/read/27808344/s100a9-induces-monocyte-macrophage-migration-via-emmprin
#4
Vasileia Ismini Alexaki, Andreas E May, Chika Fujii, Saskia N I V Ungern-Sternberg, Christine Mund, Meinrad Gawaz, Triantafyllos Chavakis, Peter Seizer
No abstract text is available yet for this article.
November 3, 2016: Thrombosis and Haemostasis
https://www.readbyqxmd.com/read/27779709/comparative-gene-expression-profiling-of-adams-mmps-timps-emmprin-egf-r-and-vegfa-in-low-grade-meningioma
#5
Harcharan K Rooprai, Andrew J Martin, Andrew King, Usha D Appadu, Huw Jones, Richard P Selway, Richard W Gullan, Geoffrey J Pilkington
MMPs (matrix metalloproteinases), ADAMs (a disintegrin and metalloproteinase) and TIMPs (tissue inhibitors of metalloproteinases) are implicated in invasion and angiogenesis: both are tissue remodeling processes involving regulated proteolysis of the extracellular matrix, growth factors and their receptors. The expression of these three groups and their correlations with clinical behaviour has been reported in gliomas but a similar comprehensive study in meningiomas is lacking. In this study, we aimed to evaluate the patterns of expression of 23 MMPs, 4 TIMPs, 8 ADAMs, selective growth factors and their receptors in 17 benign meningiomas using a quantitative real-time polymerase chain reaction (qPCR)...
October 18, 2016: International Journal of Oncology
https://www.readbyqxmd.com/read/27768590/prognostic-role-of-extracellular-matrix-metalloproteinase-inducer-cd147-in-gastrointestinal-cancer-a-meta-analysis-of-related-studies
#6
Xiaohui Huang, Weisong Shen, Hongqing Xi, Kecheng Zhang, Jianxin Cui, Bo Wei, Lin Chen
The prognostic role of Extracellular matrix metalloproteinase inducer (EMMPRIN/ CD147) in gastrointestinal cancer remains controversial. We systematically reviewed the evidence of assessment of CD147 expression in gastrointestinal cancer to help clarify this issue. Pubmed, Embase, Cochrane Library and Web of Science databases were searched to identify eligible studies to evaluate the association of CD147 expression and disease-free and overall survival of gastrointestinal cancer. Hazard ratios (HRs) were pooled to estimate the effect...
October 19, 2016: Oncotarget
https://www.readbyqxmd.com/read/27737732/anacardic-acid-inhibits-gelatinases-through-the-regulation-of-spry2-mmp-14-emmprin-and-reck
#7
Jyotsna Nambiar, Chinchu Bose, Meera Venugopal, Asoke Banerji, Tarun B Patel, Geetha B Kumar, Bipin G Nair
Earlier studies from our laboratory have identified Anacardic acid (AA) as a potent inhibitor of gelatinases (MMP-2 and 9), which are over-expressed in a wide variety of cancers (Omanakuttan et al., 2012). Disruption of the finely tuned matrix metalloproteinase (MMP) activator/inhibitor balance plays a decisive role in determining the fate of the cell. The present study demonstrates for the first time, that in addition to regulating the expression as well as activity of gelatinases, AA also inhibits the expression of its endogenous activators like MMP-14 and Extracellular Matrix MetalloProteinase Inducer (EMMPRIN) and induces the expression of its endogenous inhibitor, REversion-inducing Cysteine-rich protein with Kazal motifs (RECK)...
October 11, 2016: Experimental Cell Research
https://www.readbyqxmd.com/read/27733550/impact-of-minocycline-on-extracellular-matrix-metalloproteinase-inducer-a-factor-implicated-in-multiple-sclerosis-immunopathogenesis
#8
Jennifer N Hahn, Deepak K Kaushik, Manoj K Mishra, Jianxiong Wang, Claudia Silva, V Wee Yong
Extracellular matrix metalloproteinase inducer (EMMPRIN, CD147) is a transmembrane glycoprotein that is upregulated on leukocytes in active lesions in multiple sclerosis (MS) and its animal model, experimental autoimmune encephalomyelitis (EAE). Administration of anti-EMMPRIN Abs reduces the severity of EAE. Minocycline is a tetracycline antibiotic with immune-modulatory properties that decreases the severity of EAE; it was recently found to attenuate the conversion from a first demyelinating event to clinically definite MS in a phase III trial...
October 12, 2016: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/27727297/evaluating-soluble-emmprin-as-a-marker-of-disease-activity-in-multiple-sclerosis-studies-of-serum-and-cerebrospinal-fluid
#9
Deepak K Kaushik, Heather Y F Yong, Jennifer N Hahn, Claudia Silva, Steven Casha, R John Hurlbert, Francois H Jacques, Robert Lisak, Omar Khan, Carolina Ionete, Catherine Larochelle, Alex Prat, Amit Bar-Or, V Wee Yong
Extracellular matrix metalloproteinase inducer (EMMPRIN, CD147) is an inducer of matrix metalloproteinases and has roles in leukocyte activation and migration. We reported previously that in MS and its animal model, experimental autoimmune encephalomyelitis, cell surface-associated EMMPRIN was significantly elevated in leukocytes around inflammatory perivascular cuffs in the CNS. In this study we report that activated T-cells can secrete soluble form of EMMPRIN (sEMMPRIN) upon activation. As sEMMPRIN is also present in biological fluids, we determined whether sEMMPRIN is altered in the CSF and sera of MS subjects...
2016: PloS One
https://www.readbyqxmd.com/read/27660801/high-contrast-enzymatic-immunohistochemistry-of-pigmented-tissues
#10
Sara M Duncan, Gail M Seigel
Historically, standard enzyme immunohistochemistry has been accomplished with brown (DAB, diaminobenzidine) substrate. This can become problematic in pigmented tissues, such as the retina, where brown pigment of retinal pigmented epithelial (RPE) cells can be easily confounded with brown substrate. Although immunofluorescence detection methods can overcome this challenge, fluorescence may fade over a period of weeks, while enzyme substrates allow for more long-lasting, archival results. In this report, we will describe a high-contrast enzyme immunohistochemistry method ideal for pigmented tissues that utilizes purple (VIP) substrate...
2016: Journal of Biological Methods
https://www.readbyqxmd.com/read/27649573/nitric-oxide-induces-cardiac-protection-by-preventing-extracellular-matrix-degradation-through-the-complex-caveolin-3-emmprin-in-cardiac-myocytes
#11
Irene Cuadrado, Borja Castejon, Ana M Martin, Marta Saura, Paula Reventun-Torralba, Jose Luis Zamorano, Carlos Zaragoza
Inhibition of Extracellular Matrix degradation by nitric oxide (NO) induces cardiac protection against coronary ischemia/reperfusion (IR). Glycosylation of Extracellular Matrix Metalloproteinase Inducer (EMMPRIN) stimulates enzymatic activation of matrix metalloproteinases (MMPs) in the heart, although the mechanisms leading to EMMPRIN glycosylation are poorly understood. We sought to determine if NO may induce cardiac protection by preventing glycosylation of EMMPRIN in a mouse model of IR. Here we found that Caveolin-3 binds to low glycosylated EMMPRIN (LG-EMMPRIN) in cardiac cells and in the hearts of healthy mice, whereas IR disrupted the complex in nitric oxide synthase 2 (NOS2) knockout (KO) mice...
2016: PloS One
https://www.readbyqxmd.com/read/27608940/cd147-emmprin-overexpression-and-prognosis-in-cancer-a-systematic-review-and-meta-analysis
#12
Xiaoyan Xin, Xianqin Zeng, Huajian Gu, Min Li, Huaming Tan, Zhishan Jin, Teng Hua, Rui Shi, Hongbo Wang
CD147/EMMPRIN (extracellular matrix metalloproteinase inducer) plays an important role in tumor progression and a number of studies have suggested that it is an indicator of tumor prognosis. This current meta-analysis systematically reevaluated the predictive potential of CD147/EMMPRIN in various cancers. We searched PubMed and Embase databases to screen the literature. Fixed-effect and random-effect meta-analytical techniques were used to correlate CD147 expression with outcome measures. A total of 53 studies that included 68 datasets were eligible for inclusion in the final analysis...
2016: Scientific Reports
https://www.readbyqxmd.com/read/27597537/study-of-the-participation-of-mmp-7-emmprin-and-cyclophilin-a-in-the-pathogenesis-of-periodontal-disease
#13
Fernando José de Oliveira Nóbrega, Denise Hélen Imaculada Pereira de Oliveira, Rodrigo Gadelha Vasconcelos, Cassiano Francisco Weege Nonaka, Lélia Maria Guedes Queiroz
BACKGROUND AND OBJECTIVE: Periodontal disease is an infectious disease resulting from the immunoinflammatory response of the host to microorganisms present in the dental biofilm which causes tissue destruction. The objective of this study was to evaluate the immunohistochemical expression of matrix metalloproteinase 7 (MMP-7), extracellular matrix metalloproteinase inducer (EMMPRIN) and cyclophilin A (CypA) in periodontal disease. DESIGN: Gingival tissue samples were divided as follows: clinically healthy gingiva (n=32), biofilm-induced gingivitis (n=28), and chronic periodontitis (n=30)...
August 26, 2016: Archives of Oral Biology
https://www.readbyqxmd.com/read/27570124/exosomes-from-cardiomyocyte-progenitor-cells-and-mesenchymal-stem-cells-stimulate-angiogenesis-via-emmprin
#14
Krijn R Vrijsen, Janita A Maring, Steven A J Chamuleau, Vera Verhage, Emma A Mol, Janine C Deddens, Corina H G Metz, Kirsten Lodder, Esther C M van Eeuwijk, Susan M van Dommelen, Pieter A Doevendans, Anke M Smits, Marie-José Goumans, Joost P G Sluijter
To date, cellular transplantation therapy has not yet fulfilled its high expectations for cardiac repair. A major limiting factor is lack of long-term engraftment of the transplanted cells. Interestingly, transplanted cells can positively affect their environment via secreted paracrine factors, among which are extracellular vesicles, including exosomes: small bi-lipid-layered vesicles containing proteins, mRNAs, and miRNAs. An exosome-based therapy will therefore relay a plethora of effects, without some of the limiting factors of cell therapy...
October 2016: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/27439686/plasma-emmprin-levels-in-acute-myocardial-infarction-and-stable-coronary-artery-disease
#15
Mehmet N Akkus, Adil Ormam, Sabri Seyis, Çagdas Baran, Aysegül Görür, Mehmet N Bilen
PURPOSE: The purpose of this study was to determine whether the plasma levels of soluble extracellular matrix metalloproteinase inducer (EMMPRIN) differed among the patients with ST-elevation myocardial infarction (STEMI), non-STEMI (NSTEMI) and stable coronary artery disease (CAD) and the healthy controls, and to identify the factors associated with the differences in plasma levels of this this protein among patients in these groups. METHODS: Plasma EMMPRIN levels were compared among four age- and sex-matched groups of patients with STEMI, NSTEMI and stable CAD and healthy controls (n=44 per group), then logistic regression and correlation analyses were conducted for the whole acute myocardial infarction (AMI) patients group...
2016: Clinical and Investigative Medicine. Médecine Clinique et Experimentale
https://www.readbyqxmd.com/read/27434292/lentivirus-mediated-rna-interference-of-emmprin-cd147-gene-inhibits-the-proliferation-matrigel-invasion-and-tumor-formation-of-breast-cancer-cells
#16
Jing Yang, Rong Wang, Hongjiang Li, Qing Lv, Wentong Meng, Xiaoqin Yang
BACKGROUND: Overexpression of extracellular matrix metalloproteinase inducer (EMMPRIN) or cluster of differentiation 147 (CD147), a glycoprotein enriched on the plasma membrane of tumor cells, promotes proliferation, invasion, metastasis, and survival of malignant tumor cells. In this study, we sought to examine the expression of EMMPRIN in breast tumors, and to identify the potential roles of EMMPRIN on breast cancer cells. METHODS: EMMPRIN expression in breast cancer tissues was assessed by immunohistochemistry...
July 8, 2016: Cancer Biomarkers: Section A of Disease Markers
https://www.readbyqxmd.com/read/27429847/emmprin-sp1-and-microrna-27a-mediate-physcion-8-o-%C3%AE-glucopyranoside-induced-apoptosis-in-osteosarcoma-cells
#17
Zhaohong Wang, Huilin Yang
Physcion 8-O-β-glucopyranoside (PG), the main active ingredient of Rumex japonicus, induces apoptosis and causes cell cycle arrest in human lung cancer cells. However, its anti-tumor effects are not fully understood. In this study, we explored the mechanisms underlying PG induced apoptosis in the osteosarcoma cell line MG-63. Our results showed that PG exerted anti-proliferative effects and induced apoptosis in MG-63 cells via the intrinsic mitochondrial pathway, accompanied by loss of mitochondrial membrane potential (MMP) and cytochrome C release from the mitochondria...
2016: American Journal of Cancer Research
https://www.readbyqxmd.com/read/27398135/extracellular-matrix-metalloproteinase-inducer-cd147-bsg-emmprin-induced-radioresistance-in-cervical-cancer-by-regulating-the-percentage-of-the-cells-in-the-g2-m-phase-of-the-cell-cycle-and-the-repair-of-dna-double-strand-breaks-dsbs
#18
Xingzhu Ju, Shanhui Liang, Jun Zhu, Guihao Ke, Hao Wen, Xiaohua Wu
Our preliminary study found that CD147 is related to radioresistance and maybe an adverse prognostic factor in cervical cancer. To date, the mechanisms underlying CD147-induced radioresistance in cervical cancer remain unclear. In the present study, we investigated the mechanisms by which CD147 affects radiosensitivity in cervical cancer both in vitro and in vivo. In this study, the clonogenic assay showed that radiosensitivity was significantly higher in the experimental group (the CD147-negative cell lines) than in the control group (the CD147-positive cell lines)...
2016: American Journal of Translational Research
https://www.readbyqxmd.com/read/27388991/identification-of-an-s100a8-receptor-neuroplastin-%C3%AE-and-its-heterodimer-formation-with-emmprin
#19
Masakiyo Sakaguchi, Mami Yamamoto, Masashi Miyai, Tatsuo Maeda, Junichiro Hiruma, Hitoshi Murata, Rie Kinoshita, I Made Winarsa Ruma, Endy Widya Putranto, Yusuke Inoue, Shin Morizane, Nam-Ho Huh, Ryoji Tsuboi, Toshihiko Hibino
We previously reported a positive feedback loop between S100A8/A9 and pro-inflammatory cytokines mediated by extracellular matrix metalloproteinase inducer (EMMPRIN), an S100A9 receptor. Here, we identify neuroplastin-β (NPTNβ) as an unreported S100A8 receptor. NPTNβ and EMMPRIN form homodimers and a heterodimer, and are co-localized on the surface of cultured normal human keratinocytes (NHK). Knockdown of both receptors suppressed cell proliferation and pro-inflammatory cytokine induction. Upon stimulation with S100A8, NPTNβ recruited Grb2 and activated ERK, resulting in keratinocyte proliferation...
July 4, 2016: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/27325313/emmprin-down-regulating-mir-106a-b-modifies-breast-cancer-stem-like-cell-properties-via-interaction-with-fibroblasts-through-stat3-and-hif-1%C3%AE
#20
Yonglei Liu, Jingling Zhang, Xiangjun Sun, Meilin Li
Extracellular matrix metalloproteinase inducer (EMMPRIN) is a heavily glycosylated protein and expresses in cancer cells widely, which plays important roles in tumor progression. However, the role of EMMPRIN in breast cancer stem-like cell properties by interaction with fibroblasts is not known. In the present study, we investigated the effects of fibroblasts on breast cancer stem-like cells. We found that fibroblasts activated by co-cultured breast cancer cells produced higher levels of EMMPRIN, which stimulated the stem-like cell specific, self-renewal and sphere-forming phenotype in breast cancer cells...
2016: Scientific Reports
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