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https://www.readbyqxmd.com/read/29723143/-the-role-of-exosomal-tetraspanins-and-proteases-in-tumor-progression
#1
REVIEW
N V Yunusova, E A Tugutova, S N Tamkovich, I V Kondakova
Major (CD9, CD63, CD81) and others (CD82, CD151, Tspan8) tetraspanins are widely represented in exosomes, where they interact with various proteins and form functional tetraspanin complexes. Tetraspanin complexes include proteases. Tetraspanin-associated exosomal proteases (ADAM proteases, MMPs, EMMPRIN) play an important role in the processes of cell motility, migration, invasion and formation of metastases. Also, a significant contribution to tumor progression is made by proteases that are not associated with tetraspanins...
March 2018: Biomedit︠s︡inskai︠a︡ Khimii︠a︡
https://www.readbyqxmd.com/read/29595876/exercise-mitigates-the-effects-of-hyperhomocysteinemia-on-adverse-muscle-remodeling
#2
Lee J Winchester, Sudhakar Veeranki, Sathnur Pushpakumar, Suresh C Tyagi
Hyperhomocysteinemia (HHcy) is known for causing inflammation and vascular remodeling, particularly through production of reactive oxygen species (ROS) and matrix metalloproteinase-9 (MMP-9) activation. Although its effect on the skeletal muscle is unclear, HHcy can cause skeletal muscle weakness and functional impairment by induction of inflammatory mediators and macrophage mediated injury. Exercise has been shown to reduce homocysteine levels and therefore, could serve as a promising intervention for HHcy...
March 2018: Physiological Reports
https://www.readbyqxmd.com/read/29567202/mating-induces-production-of-mmp2-in-the-llama-oviduct-analysis-of-mmp2-effect-on-semen
#3
Renato Zampini, Luciana M Sari, Martin E Argañaraz, Fernanda G Fumuso, Daniela E Barraza, María I Carretero, Silvana A Apichela
Ovulation of South American Camelids is induced by mating. After copulation, sperm are stored into the oviduct to be released near ovulation time. To study whether copulation induces matrix metalloproteinase-2 (MMP2) secretion in the oviduct, the occurrence of MMP2 in oviductal tissue and oviductal fluid (OF) from 24 h post-mated was compared with non-mated llama females. There was an incremental increase of MMP2 in the oviductal epithelial cells, and MMP2 activity in OF after copulation. Additionally, MMP2 activator (MMP14), inducer (EMMPRIN) and inhibitor (TIMP2) were present in the oviductal epithelial cells of both non-mated and post-mated females...
March 15, 2018: Animal Reproduction Science
https://www.readbyqxmd.com/read/29491054/chemotherapeutic-effect-of-cd147-antibody-labeled-micelles-encapsulating-doxorubicin-conjugate-targeting-cd147-expressing-carcinoma-cells
#4
Tadashi Asakura, Masayuki Yokoyama, Koichi Shiraishi, Katsuhiko Aoki, Kiyoshi Ohkawa
BACKGROUND: CD147 (basigin/emmprin) is expressed on the surface of carcinoma cells. MATERIALS AND METHODS: For studying the efficacy of CD147-targeting medicine on CD147-expressing cells, we studied the effect of anti-CD147-labeled polymeric micelles (CD147ab micelles) that encapsulated a conjugate of doxorubicin with glutathione (GSH-DXR), with specific accumulation and cytotoxicity against CD147-expressing A431 human epidermoid carcinoma cells, Ishikawa human endometrial adenocarcinoma cells, and PC3 human prostate carcinoma cells...
March 2018: Anticancer Research
https://www.readbyqxmd.com/read/29419744/extracellular-matrix-metalloproteinase-inducer-emmprin-cd147-in-cardiovascular-disease
#5
REVIEW
Saskia N I von Ungern-Sternberg, Alma Zernecke, Peter Seizer
The receptor EMMPRIN is involved in the development and progression of cardiovascular diseases and in the pathogenesis of myocardial infarction. There are several binding partners of EMMPRIN mediating the effects of EMMPRIN in cardiovascular diseases. EMMPRIN interaction with most binding partners leads to disease progression by mediating cytokine or chemokine release, the activation of platelets and monocytes, as well as the formation of monocyte-platelet aggregates (MPAs). EMMPRIN is also involved in atherosclerosis by mediating the infiltration of pro-inflammatory cells...
February 8, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29315565/the-role-of-extracellular-matrix-metalloproteinase-inducer-glycosylation-in-regulating-matrix-metalloproteinases-in-periodontitis
#6
Z Zhang, X Yang, H Zhang, X Liu, S Pan, C Li
BACKGROUND AND OBJECTIVE: Extracellular matrix metalloproteinase inducer (EMMPRIN) is a transmembrane glycoprotein that may induce activation of matrix metalloproteinases (MMPs) and lead to the destruction of periodontal tissue. The level of EMMPRIN glycosylation might be involved in this process. This study aims to investigate the role of EMMPRIN glycosylation in regulating MMP-2 and MMP-9 during the progression of periodontitis. MATERIAL AND METHODS: Gingival tissues were collected from patients with chronic periodontitis and from patients undergoing crown-lengthening procedures (healthy gingival tissue)...
January 5, 2018: Journal of Periodontal Research
https://www.readbyqxmd.com/read/29282042/overexpression-of-emmprin-is-associated-with-lymph-node-metastasis-and-advanced-stage-of-non-small-cell-lung-cancer-a-retrospective-study
#7
Bing Liu, Zhaohui Wan, Baowei Sheng, Yong Lin, Tian Fu, Qingdi Zeng, Congcong Qi
BACKGROUND: Previous studies show that overexpression of EMMPRIN involved in the malignant biological behavior of tumors. This investigation was to disclose the expression status of EMMPRIN in non-small cell lung cancer (NSCLC) and its clinical value for the diagnosis of NSCLC. METHODS: The expression of EMMPRIN was examined using immunohistochemistry and enzyme-linked immunosorbent assay. The clinical value of EMMPRIN was evaluated by drawing a receiver operating characteristic (ROC) curve...
December 28, 2017: BMC Pulmonary Medicine
https://www.readbyqxmd.com/read/29251612/-interstitial-collagenase-and-their-endogenous-regulators-in-squamous-cell-cervical-carcinoma
#8
O S Timoshenko, T A Gureeva, E V Kugaevskaya, L E Zavalishina, N I Solovyeva
Interstitial collagenase (MMP-1) belongs to the family of matrix metalloproteinases (MMP), which play a key role in generalization processes of invasion and metastasis, which determine the degree of tumor malignancy. MMP-1 refers to secreted, inducible MMP, the expression of which in normal tissues is not defined. Induction of expression of MMP in CSS in the tumor occurs under the action of oncogenes of HPV, and in areas adjacent to the tumor normal tissue under the action of the inductor expression of MMP - EMMPRIN (CD147), which expressively on the surface of tumor cells...
November 2017: Biomedit︠s︡inskai︠a︡ Khimii︠a︡
https://www.readbyqxmd.com/read/29247133/dihydrotestosterone-induces-pro-angiogenic-factors-and-assists-homing-of-msc-into-the-cardiac-tissue
#9
Mirel-Adrian Popa, Maria-Cristina Mihai, Alina Constantin, Viorel Şuică, Cătălin Ţucureanu, Raluca Costache, Felicia Antohe, Raghvendra K Dubey, Maya Simionescu
The use of mesenchymal stem cells (MSC) as a therapeutic tool in cardiovascular diseases is promising. Since androgens exert some beneficial actions on the cardiovascular system, we tested our hypothesis that this hormone could promote MSC-mediated repair processes, also. Cultured MSCs isolated from Wharton's jelly were exposed to 30 nM dihydrotestosterone (DHT) for 1 or 4 days and the effects of the hormone on their growth/migration/adhesion and the underlying mechanisms were assessed. Results were obtained by real-time cell impedance measurements, and DNA quantification showed that DHT increased MSC proliferation by ~30%...
January 2018: Journal of Molecular Endocrinology
https://www.readbyqxmd.com/read/29202620/influence-of-intra-tumoral-heterogeneity-on-the-evaluation-of-bcl2-e-cadherin-egfr-emmprin-and-ki-67-expression-in-tissue-microarrays-from-breast-cancer
#10
COMPARATIVE STUDY
Trine Tramm, Marianne Kyndi, Flemming B Sørensen, Jens Overgaard, Jan Alsner
INTRODUCTION: The influence of intra-tumoral heterogeneity on the evaluation of immunohistochemical (IHC) biomarker expression may affect the analytical validity of new biomarkers substantially and hence compromise the clinical utility. The aim of this study was to examine the influence of intra-tumoral heterogeneity as well as inter-observer variability on the evaluation of various IHC markers with potential prognostic impact in breast cancer (BCL2, E-cadherin, EGFR, EMMPRIN and Ki-67)...
January 2018: Acta Oncologica
https://www.readbyqxmd.com/read/29194430/human-cytomegalovirus-encoded-mir-us25-1-5p-attenuates-cd147-emmprin-mediated-early-antiviral-response
#11
Jun Chen, Sisi Xia, Xiangmin Yang, Huizi Chen, Fanni Li, Fenyong Liu, Zhinan Chen
Cellular receptor-mediated signaling pathways play critical roles during the initial immune response to Human Cytomegalovirus (HCMV) infection. However, the involvement of type-I transmembrane glycoprotein CD147/EMMPRIN (extracellular matrix metalloproteinase inducer) in the antiviral response to HCMV infection is still unknown. Here, we demonstrated the specific knockdown of CD147 significantly decreased HCMV-induced activation of NF-κB and Interferon-beta (IFN-β), which contribute to the cellular antiviral responses...
December 1, 2017: Viruses
https://www.readbyqxmd.com/read/29163835/cd147-expression-was-positively-linked-to-aggressiveness-and-worse-prognosis-of-gastric-cancer-a-meta-and-bioinformatics-analysis
#12
Hua-Chuan Zheng, Bao-Cheng Gong
CD147 (also named as Basigin or EMMPRIN) might promote cancer invasion and metastasis by inducing MMP and VEGF synthesis in tumor microenvironment. We performed a systematic meta and bioinformatics analysis through multiple online databases up to March 14, 2017. Up-regulated CD147 expression was found in gastric cancer, compared with normal mucosa ( p < 0.05). The male patients with gastric cancer showed higher CD147 expression than the female ones ( p < 0.0001). CD147 expression was positively correlated with tumor size, depth of invasion, lymph node metastasis, TNM staging and unfavorable prognosis of gastric cancer ( p < 0...
October 27, 2017: Oncotarget
https://www.readbyqxmd.com/read/29154780/the-feedback-loop-of-emmprin-nf-%C3%AE%C2%BAb-worsens-atherosclerotic-plaque-via-suppressing-autophagy-in-macrophage
#13
Xing Liang, Xianhua Hou, Yang Yang, Hong Liu, Ruiwei Guo, Zhihua Yang, Lixia Yang
This study examined the significance of macrophage autophagy in extracellular matrix metalloproteinase inducer (EMMPRIN)-mediated atherosclerosis (AS). Apolipoprotein E-deficient (ApoE-/-) mice were fed a western diet to establish an AS model. EMMPRIN and p62/Sequestosome-1(SQSTM1) expression were evaluated in plaque macrophages from the AS mice using immunofluorescence. The EMMPRIN and p62/SQSTM1 protein expression levels in macrophages increased with the increasing vulnerability of the atherosclerotic plaques...
January 2018: Journal of Molecular and Cellular Cardiology
https://www.readbyqxmd.com/read/29149784/anti-inflammatory-property-of-%C3%AE-d-mannuronic-acid-m2000-on-expression-and-activity-of-matrix-metalloproteinase-2-and-9-through-cd147-molecule-in-phorbol-myristate-acetate-differentiated-thp-1-cells
#14
Mohadese M Farahani, Elahe Motevaseli, Faezeh Maghsood, Maryam Heidari-Kharaji, Abbas Mirshafiey
The aim of this study was to evaluate the effects of M2000, a novel non-steroidal anti-inflammatory drug (NSAID) with immunosuppressive property and without gastro-nephrotoxicitic effects on matrix metalloproteinases (MMP)-2 and (MMP)-9 in phorbol myristate acetate (PMA)-differentiated THP-1 cells. Gene expression and activity of MMP-2 and MMP-9 are inhibited respectively by the tissue inhibitor of matrix metalloproteinase (TIMP)-2 and (TIMP)-1 and are induced by extracellular matrix metalloproteinase inducer (CD147/EMMPRIN)...
October 2017: Iranian Journal of Allergy, Asthma, and Immunology
https://www.readbyqxmd.com/read/29141241/mmp-9-and-its-regulators-timp-1-and-emmprin-in-patients-with-acute-st-elevation-myocardial-infarction-a-nordistemi-substudy
#15
Trine Baur Opstad, Ingebjørg Seljeflot, Ellen Bøhmer, Harald Arnesen, Sigrun Halvorsen
OBJECTIVES: The extracellular matrix is involved in wound repair after acute myocardial infarction (AMI). We investigated whether matrix metalloproteinase (MMP)-9, tissue inhibitor of metalloproteinases (TIMP)-1, and the MMP inducer (EMMPRIN) are associated with infarct size, left ventricular function, and clinical outcome in ST-elevation-MI (STEMI). METHODS: In 243 STEMI patients, circulating EMMPRIN, MMP-9, and TIMP-1 were analyzed 3 days and 3 months post-AMI...
2018: Cardiology
https://www.readbyqxmd.com/read/29137291/the-clinicopathological-significance-and-prognostic-value-of-emmprin-overexpression-in-cancers-evidence-from-39-cohort-studies
#16
Hengwei Fan, Wanwan Yi, Chenxing Wang, Jisheng Wang
Extracellular matrix metalloproteinase inducer (EMMPRIN) has been reported to be associated with tumor formation and invasion in many studies. However, the clinicopathological significance and prognosis of EMMPRIN in cancer patients remains inconclusive. Therefore, we conducted a meta-analysis to assess the predictive potential of EMMPRIN in various cancers. By searching Pubmed, Cochrane library database and web of science comprehensively, 39studies with 5739 cases were included in our meta-analysis. The results indicated that EMMPRIN overexpression was significantly associated with poor outcome of cancers (HR=2...
October 10, 2017: Oncotarget
https://www.readbyqxmd.com/read/29105390/dual-effects-of-cell-free-supernatants-from-lactobacillus-acidophilus-and-lactobacillus-rhamnosus-gg-in-regulation-of-mmp-9-by-up-regulating-timp-1-and-down-regulating-cd147-in-pmadifferentiated-thp-1-cells
#17
Faezeh Maghsood, Abbas Mirshafiey, Mohadese M Farahani, Mohammad Hossein Modarressi, Parvaneh Jafari, Elahe Motevaseli
OBJECTIVES: Recent studies have reported dysregulated expression of matrix metalloproteinases (MMPs), especially MMP-2, MMP-9, tissue inhibitor of metalloproteinase-1, -2 (TIMP-1, TIMP-2), and extracellular matrix metalloproteinase inducer (EMMPRIN/CD147) in activated macrophages of patients with inflammatory diseases. Therefore, MMP-2, MMP-9, and their regulators may represent a new target for treatment of inflammatory diseases. Probiotics, which are comprised of lactic acid bacteria, have the potential to modulate inflammatory responses...
January 2018: Cell Journal
https://www.readbyqxmd.com/read/29104472/emmprin-inhibits-bfgf-induced-il-6-secretion-in-an-osteoblastic-cell-line-mc3t3-e1
#18
Akari Saiki, Mitsuru Motoyoshi, Keiko Motozawa, Teinosuke Okamura, Kousuke Ueki, Noriyoshi Shimizu, Masatake Asano
Background: Electrolytically-generated acid functional water (FW) is obtained by electrolyzing low concentrations of saline. Although it has been widely used in clinical practice with various purposes, the underlying mechanisms of action involved have not been fully elucidated so far. We used the human cervical cancer-derived fibroblastic cell line (HeLa), to examine the cytokine secretion profile following FW treatment in the present study. Results: FW stimulation significantly induced the secretion of basic fibroblast growth factor (bFGF) and extracellular matrix metalloproteinase inducer (EMMPRIN)...
2017: International Journal of Medical Sciences
https://www.readbyqxmd.com/read/29076374/expression-of-extracellular-matrix-metalloproteinase-inducer-and-matrix-metalloproteinase-2-and-9-in-horses-with-chronic-airway-inflammation
#19
Heini S Rossi, Ninna M Koho, Mika Ilves, Minna M Rajamäki, Anna K Mykkänen
OBJECTIVE To examine whether expression of extracellular matrix metalloproteinase inducer (EMMPRIN) can be detected in equine lungs and whether it correlates with matrix metalloproteinase (MMP)-2 and -9 expression in bronchoalveolar lavage fluid (BALF) of horses with chronic inflammation of the lungs (ie, lower airway inflammation [LAI]). ANIMALS 29 horses with signs of chronic respiratory tract disease, which were classified as the LAI (n = 17) and LAI with respiratory distress (RDLAI [12]) groups, and 15 control horses...
November 2017: American Journal of Veterinary Research
https://www.readbyqxmd.com/read/29057571/cypa-and-emmprin-play-a-role-in-peri-implantitis
#20
Lei Yang, Qing Zhu, Jingjue Gong, Ming Xie, Ting Jiao
BACKGROUND: Cyclophilin A (CyPA) and Emmprin play important roles in peri-implantitis. However, their roles in the diagnosis and treatment of the disease are still unclear. PURPOSE: The aim of this split-mouth animal study was to describe variable trends of biomarkers during the progression of peri-implantitis and to define relationships among CyPA, Emmprin, and peri-implantitis. MATERIALS AND METHODS: Six male adult Labradors were used. The mandibular premolars and the first molar were extracted, and sixteen implants were placed after 3 months...
October 22, 2017: Clinical Implant Dentistry and related Research
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