Peter Seizer, Saskia N I von Ungern-Sternberg, Verena Haug, Valerie Dicenta, Annabelle Rosa, Elke Butt, Moritz Nöthel, Anne-Katrin Rohlfing, Manuel Sigle, Peter P Nawroth, Claudia Nussbaum, Markus Sperandio, Charly Kusch, Mara Meub, Markus Sauer, Patrick Münzer, Kristin Bieber, Anna Stanger, Andreas F Mack, René Huber, Korbinian Brand, Moritz Lehners, Robert Feil, Antti Poso, Konstantin Krutzke, Tilman E Schäffer, Bernhard Nieswandt, Oliver Borst, Andreas E May, Alma Zernecke, Meinrad Gawaz, David Heinz Mann
AIMS: Cyclophilin A (CyPA) induces leukocyte recruitment and platelet activation upon release into the extracellular space. Extracellular CyPA therefore plays a critical role in immuno-inflammatory responses in tissue injury and thrombosis upon platelet activation. To date, CD147 (EMMPRIN) has been described as the primary receptor mediating extracellular effects of CyPA in platelets and leukocytes. The receptor for advanced glycation end products (RAGE) shares inflammatory and prothrombotic properties and has also been found to have similar ligands as CD147...
January 4, 2024: Cardiovascular Research