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Big data and COPD

Job J M H van Bragt, Susanne J H Vijverberg, Els J M Weersink, Levi B Richards, Anne H Neerincx, Peter J Sterk, Elisabeth H D Bel, Anke H Maitland-van der Zee
The complexity and heterogeneous nature of asthma and chronic obstructive pulmonary disease (COPD) results in difficulties in diagnosing and treating patients. Biomarkers that can identify underlying mechanisms, identify patient phenotypes and to predict treatment response could be of great value for adequate treatment. Areas covered: Biomarkers play an important role for the development of novel targeted therapies in airways disease. Blood biomarkers are relatively non-invasive, easy to obtain and easy to apply in routine care...
March 29, 2018: Expert Review of Respiratory Medicine
Anne Lindberg, Per S Bakke, Johann Christian Virchow, Bo Lundbäck
No abstract text is available yet for this article.
March 5, 2018: Respiratory Medicine
Xavier Serra-Picamal, Ramon Roman, Joan Escarrabill, Anna García-Altés, Josep Maria Argimón, Nestor Soler, Rosa Faner, Elisenda Martinez Carbonell, Antoni Trilla, Alvar Agusti
BACKGROUND: Patients with Chronic Obstructive Pulmonary Disease (COPD) may suffer episodes of exacerbation (ECOPD) that require hospitalization and worsen their health status, and prognosis. We hypothesized that a detailed interrogation of health-care "big data" databases can provide valuable information to better understand the risk factors and outcomes of these episodes. MATERIAL AND METHODS: We interrogated four databases of the Catalan health-care system (>8,000,000 registries) to identify patients hospitalized because of ECOPD for the first time (index event) between 2010 and 2012...
January 16, 2018: Respiratory Medicine
Alberto Papi, Maria Sandra Magnoni, Carmelo Caio Muzzio, Gianmarco Benso, Andrea Rizzi
The Evaluation of COPD Longitudinally to Identify Predictive Surrogate End-points (ECLIPSE) study was a large 3-year observational multicentre international study aimed at defining COPD phenotypes and identifying biomarkers and/or genetic parameters that help to predict disease progression. The study has contributed to a better understanding of COPD heterogeneity, with the characterization of clinically important subtypes/phenotypes of patients, such as the frequent exacerbators or patient with persistent systemic inflammation, who may have different prognosis or treatment requirements...
October 14, 2016: Monaldi Archives for Chest Disease, Archivio Monaldi Per le Malattie del Torace
Kyriakos Souliotis, Chara Kani, Manto Papageorgiou, Dimitrios Lionis, Konstantinos Gourgoulianis
INTRODUCTION: Chronic Obstructive Pulmonary Disease (COPD) is one of the top leading causes of death and disability, and its management is focused on reducing risk factors, relieving symptoms, and preventing exacerbations. The study aim was to describe COPD prescribing patterns in Greece by using existing health administrative data for outpatients. METHODS: This is a retrospective cross-sectional study based on prescriptions collected by the largest social insurance fund, during the first and last trimester of 2012...
2016: PloS One
Bernd Schmeck, Wilhelm Bertrams, Xin Lai, Julio Vera
Lung diseases cause an enormous socioeconomic burden. Four of them are among the ten most important causes of deaths worldwide: Pneumonia has the highest death toll of all infectious diseases, lung cancer kills the most people of all malignant proliferative disorders, chronic obstructive pulmonary disease (COPD) ranks third in mortality among the chronic noncommunicable diseases, and tuberculosis is still one of the most important chronic infectious diseases. Despite all efforts, for example, by the World Health Organization and clinical and experimental researchers, these diseases are still highly prevalent and harmful...
2016: Methods in Molecular Biology
Matthew Toews, Christian Wachinger, Raul San Jose Estepar, William M Wells
This paper proposes an inference method well-suited to large sets of medical images. The method is based upon a framework where distinctive 3D scale-invariant features are indexed efficiently to identify approximate nearest-neighbor (NN) feature matches-in O (log N) computational complexity in the number of images N. It thus scales well to large data sets, in contrast to methods based on pair-wise image registration or feature matching requiring O(N) complexity. Our theoretical contribution is a density estimator based on a generative model that generalizes kernel density estimation and K-nearest neighbor (KNN) methods...
2015: Information Processing in Medical Imaging: Proceedings of the ... Conference
Masaji Nishimura
High-flow nasal cannula (HFNC) oxygen therapy comprises an air/oxygen blender, an active humidifier, a single heated circuit, and a nasal cannula. It delivers adequately heated and humidified medical gas at up to 60 L/min of flow and is considered to have a number of physiological effects: reduction of anatomical dead space, PEEP effect, constant fraction of inspired oxygen, and good humidification. While there have been no big randomized clinical trials, it has been gaining attention as an innovative respiratory support for critically ill patients...
2015: Journal of Intensive Care
Vadim G Pischik
BACKGROUND: Data on advantages of video-assisted thoracoscopic surgery (VATS) lobectomies has been accumulated during the last 10 years then number of thoracoscopic anatomic pulmonary resections rapidly increased. But still there is no agreement about limitations of the method. The most popular "technical contraindications" for VATS anatomic pulmonary resections are: dense pleural adhesions, incompleteness of interlobar fissure, previous chemo- or/and radiotherapy, perivascular or/and peribronchial fibrosis, tumor larger than 5 cm, chest wall involvement, centrally located tumor, severe comorbidity, advanced age, severe COPD and emphysema...
October 2014: Journal of Thoracic Disease
Mehmet Polatli, Turkish Thoracic Society Copd Audit Turkey Study Group
COPD Diagnosis and Evaluation Posters ISESSION TYPE: Original Investigation PosterPRESENTED ON: Wednesday, October 29, 2014 at 01:30 PM - 02:30 PMPURPOSE: According to the report of Ministry of Health, COPD is ranked as third disease causing death at national level in Turkey and chronic airway diseases have a very big influence on the health expenses. Although effective guidelines are developed systematically to be used easily in busy practices and to ensure scientifically valid outcomes, guidelines alone cannot improve patient care...
October 1, 2014: Chest
(no author information available yet)
The research presents the authors' analysis of epidemiology of chronic obstructive pulmonary disease (COPD) in a big industrial city of Middle Volga. 2063 persons (903 men and 1160 women) were examined in four age groups (30-39 years, 40-49 years, 50-59 years, 60 years and upward) in Kirovskiy and Krasnoglinskiy districts of Samara. COPD was found out in 14,49% among 2063 examined people (30-39 years--10.76%, 40-49 years--10.89%, 50-59 years--15.88%, 60 years and upward--21.30%). COPD was found out in 18.72% among 903 examined men and in 11...
2010: Advances in Gerontology, Uspekhi Gerontologii
Stephan von Haehling, Stefan D Anker
Cachexia is a serious, however underestimated and underrecognised medical consequence of malignant cancer, chronic heart failure (CHF), chronic kidney disease (CKD), chronic obstructive pulmonary disease (COPD), cystic fibrosis, rheumatoid arthritis, Alzheimer's disease, infectious diseases, and many other chronic illnesses. The prevalence of cachexia is high, ranging from 5% to 15% in CHF or COPD to 60% to 80% in advanced cancer. By population prevalence, the most frequent cachexia subtypes are in order: COPD cachexia, cardiac cachexia (in CHF), cancer cachexia, and CKD cachexia...
September 2010: Journal of Cachexia, Sarcopenia and Muscle
Kevin J Carroll
Time to event outcome trials in clinical research are typically large, expensive and high-profile affairs. Such trials are commonplace in oncology and cardiovascular therapeutic areas but are also seen in other areas such as respiratory in indications like chronic obstructive pulmonary disease. Their progress is closely monitored and results are often eagerly awaited. Once available, the top line result is often big news, at least within the therapeutic area in which it was conducted, and the data are subsequently fully scrutinized in a series of high-profile publications...
October 2009: Pharmaceutical Statistics
P Trerotoli, N Bartolomeo, A M Moretti, G Serio
BACKGROUND AND AIM: Chronic Obstructive Pulmonary Disease (COPD), although largely preventable, is a great health burden in all the countries worldwide. Statistics of morbidity and mortality of COPD show the need for correct management of the disease. Chronic Obstructive Respiratory Diseases (DRG 88) are in 9th place for discharge in in-patient hospital admission. It is necessary to establish specific indicators which are efficacious and relevant for the patient, the doctor and the health manager...
September 2008: Monaldi Archives for Chest Disease, Archivio Monaldi Per le Malattie del Torace
Maria Gerhardsson de Verdier
Tobacco use is the leading preventable cause of death and morbidity in the world. Chronic obstructive pulmonary disease (COPD), lung cancer, and cardiovascular disease (CVD) are the three major smoking-induced diseases that co-exist and can be detected at an early stage by screening, but are usually recognized in an advanced stage and treated as single entities. New epidemiologic data indicate a common origin of these diseases in susceptible individuals, and potential disease modification. Further exploration of a holistic concept of the Big Three smoking-induced diseases-COPD, lung cancer, and CVD-may be one way of reducing the burden of illness for individuals and society...
December 1, 2008: Proceedings of the American Thoracic Society
B Boggia, F Napolano, L Cavaliere, A Farina, R Ferrucci, L Visciglio, U Carbone
According to WHO, COPD will be the 5th cause of disability and the 3rd cause of mortality by 2020. Even cigarette smoking represents the main cause of COPD recent studies demonstrated positive association with occupational exposure. In Europe costs of COPD were estimated at about 38,8 billion Euros in 2000; its burden is also expected to increase. Aim of the study is to evaluate the burden of COPD on health profiles in a sample of workers of Campania region. Prevalences were calculated in a sample of 908 male workers, employed in industrial (479) and tertiary (429) sectors...
July 2007: Giornale Italiano di Medicina del Lavoro Ed Ergonomia
J Geiseler, O Karg
Acute ventilatory insufficiency is characterized by hypercapnia, respiratory acidosis and secondary hypoxemia. The primary target of mechanical ventilation is improvement of alveolar ventilation, that means compensation of the ventilatory insufficiency. Noninvasive ventilation started as ventilatory support during the big polio epidemic, at that time in form of negative pressure ventilation. In the last two decades NIV is in form of positive pressure ventilation important for long-term ventilation at home, but there is also growing importance of NIV in the treatment of acute respiratory insufficiency in the intensive care unit...
August 2007: Pneumologie
Amer Aziz, Ihsan Ullah Bajwa
Impact of urban air pollution has variety of focuses such as urban ecology, human health, economy, etc. But human health is always given priority. Air pollution is threat to the lives of people living in big cities of Pakistan. In Lahore only there die 1,250 people annually because of air pollution. A strong correlation exists between urban air pollution and human health in Lahore. Growth of COPD is highest among other air pollution borne diseases. Existing mass transit system (one of driving forces behind motor vehicular emission) in Lahore due to frequent stoppages, entering and exit in flow of traffic causes excess discharge of motor vehicular carbon monoxide (CO) which is a hazardous to human health...
December 2007: Environmental Monitoring and Assessment
C M de San Román y de Terán, R Guijarro Merino
BACKGROUND: Description of the patients admitted in the general Internal Medicine (IM) departments of the Public Health System in Andalusia (Spain) (PHSA) during 2002. PATIENTS AND METHODS: It is an analysis of the Minimum Basic Set of Data (MBSD) and its management by the Diagnostic Related Groups (DRG) of admission episodes in Andalusian public hospitals. We divided the hospitals into group 1: more than 600 beds; group 2: between 200 and 600 beds, and group 3: less than 200 beds...
January 2006: Revista Clínica Española
Manon M Kuilboer, Marc A M van Wijk, Mees Mosseveld, Emiel van der Does, Ben P Ponsioen, Johan C de Jongste, Shelley E Overbeek, Johan van der Lei
BACKGROUND: Introducing decision-support systems as a tool to stimulate the dissemination of clinical guidelines in daily practice has been disappointing. Researchers have argued that integration of such systems with clinical practice is a prerequisite for acceptance. The big question concerns the feasibility of a true integration--if only routinely recorded data are used for such a system, can patient-specific feedback be produced? OBJECTIVE: The aim of this study was to assess the feasibility of generating patient-specific feedback based on routinely recorded data in general practice by AsthmaCritic, a decision-support system for asthma and chronic obstructive pulmonary disease (COPD)...
October 2002: Family Practice
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