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Network analysis and COPD

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https://www.readbyqxmd.com/read/29021576/the-recording-and-characteristics-of-pulmonary-rehabilitation-in-patients-with-copd-using-the-health-information-network-thin-primary-care-database
#1
Ali Hakamy, Tricia M McKeever, Jack E Gibson, Charlotte E Bolton
Pulmonary rehabilitation is recommended for patients with COPD to improve physical function, breathlessness and quality of life. Using The Health Information Network (THIN) primary care database in UK, we compared the demographic and clinical parameters of patients with COPD in relation to coding of pulmonary rehabilitation, and to investigate whether there is a survival benefit from pulmonary rehabilitation. We identified patients with COPD, diagnosed from 2004 and extracted information on demographics, pulmonary rehabilitation and clinical parameters using the relevant Read codes...
October 11, 2017: NPJ Primary Care Respiratory Medicine
https://www.readbyqxmd.com/read/29020824/biomarkers-of-oxidative-stress-and-protein-protein-interaction-in-chronic-obstructive-pulmonary-disease
#2
Taru Aggarwal, Ridhima Wadhwa, Vishwajeet Rohil, Pawan Kumar Maurya
CONTENT: The increased oxidative stress in chronic obstructive pulmonary disease (COPD) patients is the result of increased inhaled oxidants, generated by various cells of the airways. OBJECTIVE: The investigation included measurements of malondiadehyde (MDA), uric acid, ascorbic acid, and matrix metalloproteinase-12 (MMP-12) in COPD patient. We also performed genetic analysis for protein-protein interaction (PPI) network. MATERIALS AND METHODS: The study was conducted on healthy subjects with normal lung function (NS, 14 subjects) and 28 patients (Global Initiative for Chronic Obstructive Lung Disease (Gold) 1 and Gold 2) with COPD...
October 11, 2017: Archives of Physiology and Biochemistry
https://www.readbyqxmd.com/read/29016655/meta-analysis-of-peripheral-blood-gene-expression-modules-for-copd-phenotypes
#3
Dominik Reinhold, Jarrett D Morrow, Sean Jacobson, Junxiao Hu, Benjamin Ringel, Max A Seibold, Craig P Hersh, Katerina J Kechris, Russell P Bowler
Chronic obstructive pulmonary disease (COPD) occurs typically in current or former smokers, but only a minority of people with smoking history develops the disease. Besides environmental factors, genetics is an important risk factor for COPD. However, the relationship between genetics, environment and phenotypes is not well understood. Sample sizes for genome-wide expression studies based on lung tissue have been small due to the invasive nature of sample collection. Increasing evidence for the systemic nature of the disease makes blood a good alternative source to study the disease, but there have also been few large-scale blood genomic studies in COPD...
2017: PloS One
https://www.readbyqxmd.com/read/28976774/proteomic-analysis-of-extracellular-hmgb1-identifies-binding-partners-and-exposes-its-potential-role-in-airway-epithelial-cell-homeostasis
#4
Sharon L I Wong, Joyce To, Jerran Santos, Venkata Sita Rama Raju Allam, John P Dalton, Steven Philip Djordjevic, Sheila Donnelly, Matthew Paul Padula, Maria B Sukkar
The release of damage-associated molecular patterns (DAMPs) by airway epithelial cells is believed to play a crucial role in the initiation and development of chronic airway conditions such as asthma and chronic obstructive pulmonary disease (COPD). Intriguingly, the classic DAMP high-mobility group box-1 (HMGB1) is detected in the culture supernatant of airway epithelial cells under basal conditions, indicating a role for HMGB1 in the regulation of epithelial cellular and immune homeostasis. In order to gain contextual insight into the potential role of HMGB1 in airway epithelial cell homeostasis, we used the orthogonal and complimentary methods of high resolution clear native electrophoresis, immunoprecipitation and pull-downs, coupled to liquid chromatography-tandem mass spectrometry (LC-MS/MS) to profile HMGB1 and its binding partners in the culture supernatant of unstimulated airway epithelial cells...
October 4, 2017: Journal of Proteome Research
https://www.readbyqxmd.com/read/28954781/multi-level-differential-network-analysis-of-copd-exacerbations
#5
Guillaume Noell, Borja G Cosío, Rosa Faner, Eduard Monsó, German Peces-Barba, Alfredo de Diego, Cristobal Esteban, Joaquim Gea, Robert Rodriguez-Roisin, Marian Garcia-Nuñez, Francisco Pozo-Rodriguez, Susana G Kalko, Alvar Agustí
Patients with chronic obstructive pulmonary disease (COPD) often suffer episodes of exacerbation (ECOPD) that impact negatively the course of their disease. ECOPD are heterogeneous events of unclear pathobiology and non-specific diagnosis. Network analysis is a novel research approach that can help unravelling complex biological systems. We hypothesised that the comparison of multi-level (i.e., clinical, physiological, biological, imaging and microbiological) correlation networks determined during ECOPD and convalescence can yield novel patho-biologic information...
September 2017: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
https://www.readbyqxmd.com/read/28943559/early-detection-of-chronic-obstructive-pulmonary-disease-in-primary-care
#6
Seiichi Kobayashi, Hanagama Masakazu, Masaru Yanai
Objective To evaluate the effectiveness of an early detection program for chronic obstructive pulmonary disease (COPD) in a primary care setting in Japan. Methods Participants of ≥40 years of age who regularly visited a general practitioner's clinic due to chronic disease were asked to complete a COPD screening questionnaire (COPD Population Screener; COPD-PS) and undergo simplified spirometry using a handheld spirometric device. Patients who showed possible COPD were referred to a respiratory specialist and underwent a detailed examination that included spirometry and chest radiography...
September 25, 2017: Internal Medicine
https://www.readbyqxmd.com/read/28892454/disease-staging-and-prognosis-in-smokers-using-deep-learning-in-chest-computed-tomography
#7
Germán González, Samuel Y Ash, Gonzalo Vegas Sanchez-Ferrero, Jorge Onieva Onieva, Farbod N Rahaghi, James C Ross, Alejandro Díaz, Raúl San José Estépar, George R Washko
RATIONALE: Deep learning is a powerful tool that may allow for improved outcome prediction. OBJECTIVES: To determine if deep learning, specifically convolutional neural network (CNN) analysis, could detect and stage chronic obstructive pulmonary disease (COPD) and predict acute respiratory disease events (ARD) and mortality in smokers. METHODS: A CNN was trained using CT scans from 7,983 COPDGene participants and evaluated using 1000 non-overlapping COPDGene participants and 1,672 ECLIPSE participants...
September 11, 2017: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/28886252/total-airway-count-on-computed-tomography-and-the-risk-of-copd-progression-findings-from-a-population-based-study
#8
Miranda Kirby, Naoya Tanabe, Wan C Tan, Guohai Zhou, Ma'en Obeidat, Cameron J Hague, Jonathon Leipsic, Jean Bourbeau, Don D Sin, James C Hogg, Harvey O Coxson
RATIONALE: Studies of excised lungs show that significant airway attrition in the 'quiet' zone occurs early in chronic obstructive pulmonary disease (COPD). OBJECTIVES: To determine if the total number of airways quantified in vivo using computed tomography (CT) reflects early airway-related disease changes and is associated with lung-function decline independent of emphysema in COPD. METHODS: Participants in the multi-centre, population-based, longitudinal CanCOLD study underwent inspiratory/expiratory CT at visit-1; spirometry was performed at four visits over 6-years...
September 8, 2017: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/28873096/chronic-obstructive-pulmonary-disease-candidate-gene-prioritization-based-on-metabolic-networks-and-functional-information
#9
Xinyan Wang, Wan Li, Yihua Zhang, Yuyan Feng, Xilei Zhao, Yuehan He, Jun Zhang, Lina Chen
Chronic obstructive pulmonary disease (COPD) is a multi-factor disease, in which metabolic disturbances played important roles. In this paper, functional information was integrated into a COPD-related metabolic network to assess similarity between genes. Then a gene prioritization method was applied to the COPD-related metabolic network to prioritize COPD candidate genes. The gene prioritization method was superior to ToppGene and ToppNet in both literature validation and functional enrichment analysis. Top-ranked genes prioritized from the metabolic perspective with functional information could promote the better understanding about the molecular mechanism of this disease...
2017: PloS One
https://www.readbyqxmd.com/read/28753070/impact-of-mucolytic-agents-on-copd-exacerbations-a-pair-wise-and-network-meta-analysis
#10
Mario Cazzola, Paola Rogliani, Luigino Calzetta, Nicola A Hanania, Maria Gabriella Matera
Mucolytics are potentially useful for the management of chronic obstructive pulmonary disease (COPD), although there is conflicting advice on their use in different guideline documents. Furthermore, there is paucity of data comparing the efficacy of the different mucolytic agents in reducing the odds of COPD exacerbations. We performed pair-wise and network meta-analyses to evaluate the impact of mucoly-tics in COPD. Randomized clinical trials lasting at least 3 months and investigating the effects of mucolytics on COPD exacerbations were identified from published studies and repository databases...
October 2017: COPD
https://www.readbyqxmd.com/read/28750556/the-quebec-respiratory-health-education-network-integrating-a-model-of-self-management-education-in-copd-primary-care
#11
Jean Bourbeau, Raquel Farias, Pei Zhi Li, Guylaine Gauthier, Livia Battisti, Valérie Chabot, Marie-France Beauchesne, Denis Villeneuve, Patricia Côté, Louis-Philippe Boulet
The objective of this study is to evaluate whether a chronic obstructive pulmonary disease (COPD) self-management education program with coaching of a case manager improves patient-related outcomes and leads to practice changes in primary care. COPD patients from six family medicine clinics (FMCs) participated in a 1-year educational program offered by trained case managers who focused on treatment adherence, inhaler techniques, smoking cessation, and the use of an action plan for exacerbations. Health-care utilization, health-related quality of life (HRQL), treatment adherence, inhaler technique, and COPD knowledge were assessed at each visit with validated questionnaires...
January 1, 2017: Chronic Respiratory Disease
https://www.readbyqxmd.com/read/28745788/the-application-value-of-continuous-nursing-for-home-oxygen-therapy-of-patients-in-the-stable-phase-of-chronic-obstructive-pulmonary-disease
#12
Y-L Yu, X-S Zheng, X-X Han, M-J Sun
OBJECTIVE: To analyze the application value of continuous nursing in improving the effects of home oxygen therapy for patients in the stable phase of chronic obstructive pulmonary disease (COPD). PATIENTS AND METHODS: Patients in the stable phase of COPD (n=106) were selected and divided into the control group and observation group based on parity digit of their admission number. There were 53 cases in each group. The patients in the control group received COPD health education at discharge, while the observation group received continuous nursing...
July 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28732830/impact-of-laba-lama-combination-on-exercise-endurance-and-lung-hyperinflation-in-copd-a-pair-wise-and-network-meta-analysis
#13
REVIEW
Luigino Calzetta, Josuel Ora, Francesco Cavalli, Paola Rogliani, Denis E O'Donnell, Mario Cazzola
BACKGROUND: The ability to exercise is an important clinical outcome in COPD, and the improvement in exercise capacity is recognized to be an important goal in the management of COPD. Therefore, since the current interest in the use of bronchodilators in COPD is gradually shifting towards the dual bronchodilation, we carried out a meta-analysis to evaluate the impact of LABA/LAMA combination on exercise capacity and lung hyperinflation in COPD. METHODS: RCTs were identified after a search in different databases of published and unpublished trials...
August 2017: Respiratory Medicine
https://www.readbyqxmd.com/read/28715281/admission-for-copd-exacerbation-is-associated-with-the-clinical-diagnosis-of-pulmonary-hypertension-results-from-a-retrospective-longitudinal-study-of-a-veteran-population
#14
Sarah K Medrek, Amir Sharafkhaneh, Andrew M Spiegelman, Arnav Kak, Lavannya M Pandit
Patients with chronic obstructive pulmonary disease and pulmonary hypertension (PH-COPD) have an increased risk of hospitalizations and death compared to COPD alone. Identifying PH in COPD is challenging because performing right heart catheterization, the gold standard for PH diagnosis, is invasive and not routinely performed. Clinical characterization of COPD patients at risk who are progressing toward PH will aid therapeutic development at earlier stages of progressively fatal PH-COPD. We studied the records of 5,45,086 patients in a large Veterans Affairs healthcare network (2000-2012) with a primary discharge diagnosis of COPD based on encounters' ICD-9 codes and further stratified into those who received an additional ICD-9 code for a PH diagnosis...
July 17, 2017: COPD
https://www.readbyqxmd.com/read/28704452/influence-of-lung-ct-changes-in-chronic-obstructive-pulmonary-disease-copd-on-the-human-lung-microbiome
#15
Marion Engel, David Endesfelder, Brigitte Schloter-Hai, Susanne Kublik, Michael S Granitsiotis, Piera Boschetto, Mariarita Stendardo, Imre Barta, Balazs Dome, Jean-François Deleuze, Anne Boland, Joachim Müller-Quernheim, Antje Prasse, Tobias Welte, Jens Hohlfeld, Deepak Subramanian, David Parr, Ivo Glynne Gut, Timm Greulich, Andreas Rembert Koczulla, Adam Nowinski, Dorota Gorecka, Dave Singh, Sumit Gupta, Christopher E Brightling, Harald Hoffmann, Marion Frankenberger, Thomas P Hofer, Dorothe Burggraf, Marion Heiss-Neumann, Loems Ziegler-Heitbrock, Michael Schloter, Wolfgang Zu Castell
BACKGROUND: Changes in microbial community composition in the lung of patients suffering from moderate to severe COPD have been well documented. However, knowledge about specific microbiome structures in the human lung associated with CT defined abnormalities is limited. METHODS: Bacterial community composition derived from brush samples from lungs of 16 patients suffering from different CT defined subtypes of COPD and 9 healthy subjects was analyzed using a cultivation independent barcoding approach applying 454-pyrosequencing of 16S rRNA gene fragment amplicons...
2017: PloS One
https://www.readbyqxmd.com/read/28685036/mapping-the-global-research-landscape-and-knowledge-gaps-on-multimorbidity-a-bibliometric-study
#16
Xiaolin Xu, Gita D Mishra, Mark Jones
BACKGROUND: To summarize global research trends and activities on multimorbidity; then to assess the knowledge gaps and to identify implications for knowledge exchange between high income countries (HICs) and low- and middle- income countries (LMICs). METHODS: A comprehensive search was conducted to identify research publications on multimorbidity in the Web of Science(TM), as well as diabetes, depression, hypertension, and Chronic Obstructive Pulmonary Disease (COPD)...
June 2017: Journal of Global Health
https://www.readbyqxmd.com/read/28558695/azithromycin-and-risk-of-copd-exacerbations-in-patients-with-and-without-helicobacter-pylori
#17
Seung Won Ra, Marc A Sze, Eun Chong Lee, Sheena Tam, Yeni Oh, Nick Fishbane, Gerard J Criner, Prescott G Woodruff, Stephen C Lazarus, Richard Albert, John E Connett, Meilan K Han, Fernando J Martinez, Shawn D Aaron, Robert M Reed, S F Paul Man, Don D Sin
BACKGROUND: Helicobacter pylori (HP) infection is associated with reduced lung function and systemic inflammation in chronic obstructive pulmonary disease (COPD) patients. Azithromycin (AZ) is active against HP and reduces the risk of COPD exacerbation. We determined whether HP infection status modifies the effects of AZ in COPD patients. METHODS: Plasma samples from 1018 subjects with COPD who participated in the Macrolide Azithromycin (MACRO) in COPD Study were used to determine the HP infection status at baseline and 12 months of follow-up using a serologic assay...
May 30, 2017: Respiratory Research
https://www.readbyqxmd.com/read/28476472/adverse-outcomes-associated-with-pulmonary-hypertension-in-chronic-obstructive-pulmonary-disease-after-bilateral-lung-transplantation
#18
Don Hayes, Dmitry Tumin, Maria M Budev, Joseph D Tobias, Roy C St John, Jasleen Kukreja
BACKGROUND: The impact of pulmonary hypertension (PH) in chronic obstructive pulmonary disease (COPD) on survival after lung transplantation (LTx) is not known. MATERIAL AND METHODS: First-time adult LTx recipients with COPD transplanted between May 2005 and September 2013 were identified in the United Network for Organ Sharing Registry database, and tracked from transplant date until death or censoring. Right heart catheterization (RHC) measurements at time of wait listing were used to predict all-cause mortality after LTx, with multivariable analyses stratified by transplant type...
July 2017: Respiratory Medicine
https://www.readbyqxmd.com/read/28438154/network-based-analysis-reveals-novel-gene-signatures-in-peripheral-blood-of-patients-with-chronic-obstructive-pulmonary-disease
#19
Ma'en Obeidat, Yunlong Nie, Virginia Chen, Casey P Shannon, Anand Kumar Andiappan, Bernett Lee, Olaf Rotzschke, Peter J Castaldi, Craig P Hersh, Nick Fishbane, Raymond T Ng, Bruce McManus, Bruce E Miller, Stephen Rennard, Peter D Paré, Don D Sin
BACKGROUND: Chronic obstructive pulmonary disease (COPD) is currently the third leading cause of death and there is a huge unmet clinical need to identify disease biomarkers in peripheral blood. Compared to gene level differential expression approaches to identify gene signatures, network analyses provide a biologically intuitive approach which leverages the co-expression patterns in the transcriptome to identify modules of co-expressed genes. METHODS: A weighted gene co-expression network analysis (WGCNA) was applied to peripheral blood transcriptome from 238 COPD subjects to discover co-expressed gene modules...
April 24, 2017: Respiratory Research
https://www.readbyqxmd.com/read/28396329/outcomes-of-patients-with-chronic-obstructive-pulmonary-disease-diagnosed-with-or-without-pulmonary-function-testing
#20
Andrea Gershon, Graham Mecredy, Ruth Croxford, Teresa To, Matthew B Stanbrook, Shawn D Aaron
BACKGROUND: A small number of people with chronic obstructive pulmonary disease (COPD) receive pulmonary function testing around the time of diagnosis. Because omitting testing increases misdiagnosis, we sought to determine whether health outcomes differed between patients whose COPD was diagnosed with or without pulmonary function testing. METHODS: We conducted a longitudinal population study of patients with physician-diagnosed COPD from 2005 to 2012 using health administrative data from Ontario, Canada...
April 10, 2017: CMAJ: Canadian Medical Association Journal, Journal de L'Association Medicale Canadienne
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