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Network analysis and COPD

Sarah Masefield, Pippa Powell, Carlos Jiménez-Ruiz, Peter Hajek, Keir Lewis, Stefan Andreas, Philip Tønnesen, Onno van Schayck, Christina Gratziou, Bertrand Dautzenberg, Serena Tonstad, Thomas Hering, Stephano Nardini, Monica Fletcher
This study aimed to gain insight into the impact of lung conditions on smoking behaviour and smoking cessation, and identify recommendations for smoking cessation and professional-patient communications. The study was led by the European Lung Foundation in collaboration with the European Respiratory Society Task Force on "Statement on smoking cessation on COPD and other pulmonary diseases and in smokers with comorbidities who find it difficult to quit". A web-based observational cross-sectional questionnaire was developed from a patient-centered literature review...
April 2016: ERJ Open Research
Seiichi Kobayashi, Masakazu Hanagama, Shinsuke Yamanda, Masatsugu Ishida, Masaru Yanai
BACKGROUND: The clinical phenotypes and underlying mechanisms of asthma-COPD overlap syndrome (ACOS) remain elusive. This study aimed to investigate a comparison of COPD patients with and without ACOS, focusing on inflammatory biomarkers, in an outpatient COPD cohort. METHODS: We conducted a cross-sectional study analyzing prospectively collected data from the Ishinomaki COPD Network registry. All participants were diagnosed with COPD, confirmed by using spirometry, and were aged 40-90 years and former smokers...
2016: International Journal of Chronic Obstructive Pulmonary Disease
John Platig, Peter J Castaldi, Dawn DeMeo, John Quackenbush
Genome Wide Association Studies (GWAS) and expression quantitative trait locus (eQTL) analyses have identified genetic associations with a wide range of human phenotypes. However, many of these variants have weak effects and understanding their combined effect remains a challenge. One hypothesis is that multiple SNPs interact in complex networks to influence functional processes that ultimately lead to complex phenotypes, including disease states. Here we present CONDOR, a method that represents both cis- and trans-acting SNPs and the genes with which they are associated as a bipartite graph and then uses the modular structure of that graph to place SNPs into a functional context...
September 2016: PLoS Computational Biology
Mohd Imran Khan, Ashish Kumar Gupta, Domada Ratna Kumar, Manoj Kumar, Abdul Samarth Ethayathulla, Gururao Hariprasad
Weight loss is a well known systemic manifestation of chronic obstructive pulmonary disease (COPD). A Gly80Ser mutation on human group IID secretory phospholipase A2 (sPLA2) enhances expression of the cytokines that are responsible for weight loss. In this study, we seek to establish a structural correlation of wild type sPLA2 and the Gly80Ser mutation with function. sPLA2 with glycine and serine at the 80th positions and the M-type receptor were modelled. The enzymes were docked to the receptor and molecular dynamics was carried out to 70 ns...
September 2016: Journal of Molecular Modeling
Lystra P Hayden, Michael H Cho, Merry-Lynn N McDonald, James D Crapo, Terri H Beaty, Edwin K Silverman, Craig P Hersh
RATIONALE: Prior studies have indicated that in adult smokers a history of childhood pneumonia is associated with reduced lung function and chronic obstructive pulmonary disease (COPD). There have been few prior investigations using genome-wide association studies (GWAS) to investigate genetic predisposition for pneumonia. This study aims to identify genetic variants associated with development of pneumonia during childhood and over the course of the lifetime. METHODS: Study subjects included current and former smokers with and without COPD participating in the COPDGene Study...
August 10, 2016: American Journal of Respiratory Cell and Molecular Biology
Pradeep Arora, Anu Gupta, Mojgan Golzy, Nilang Patel, Randolph L Carter, Kabir Jalal, James W Lohr
BACKGROUND: Acute interstitial nephritis secondary to proton pump inhibitors (PPIs) frequently goes undiagnosed due to its subacute clinical presentation, which may later present as chronic kidney disease (CKD). We investigated the association of PPI use with the development of CKD and death. METHODS: Two separate retrospective case-control study designs were employed with a prospective logistic regression analysis of data to evaluate the association of development of CKD and death with PPI use...
August 3, 2016: BMC Nephrology
Yingxin Zhao, Bing Tian, Rovshan G Sadygov, Yueqing Zhang, Allan R Brasier
UNLABELLED: The airway epithelium is a semi-impermeable barrier whose disruption by growth factor reprogramming is associated with chronic airway diseases of humans. Transforming growth factor beta (TGFβ)-induced epithelial mesenchymal transition (EMT) plays important roles in airway remodeling characteristic of idiopathic lung fibrosis, asthma and chronic obstructive pulmonary disease (COPD). Inflammation of the airways leads to airway injury and tumor necrosis factor alpha (TNFα) plays an important pro-inflammatory role...
October 4, 2016: Journal of Proteomics
Fei Zhou, Li Gu, Jiuxin Qu, Yingmei Liu, Bin Cao
INTRODUCTION: Binax NOW rapid immunochromatographic membrane test (ICT), a rapid method for detection of Streptococcus pneumoniae antigen, has been used widely in Europe and America, but rarely in China. OBJECTIVE: Our aim is to evaluate the utility of the ICT among adult patients with community acquired pneumonia (CAP) in China. METHODS: Adult patients with CAP were prospectively recruited from 12 general hospitals. ICT tests were done in all patients and clinical data were recorded...
July 20, 2016: Clinical Respiratory Journal
N Gupta, L Pinto, A Benedetti, P Z Li, W Tan, S Aaron, K R Chapman, J M FitzGerald, P Hernandez, D Marciniuk, F Maltais, D O'Donnell, D Sin, B Walker, J Bourbeau
BACKGROUND: The COPD Assessment Test (CAT) is a valid disease specific questionnaire measuring health status. However, knowledge concerning its use regarding patient and disease characteristics remains limited. Our main objective was to assess the degree to which the CAT score varies and can discriminate between specific patient population groups. METHODS: The Canadian Cohort Obstructive Lung Disease (CanCOLD) is a random-sampled population-based, multicenter prospective cohort that includes subjects with COPD: GOLD 1 to 3...
June 27, 2016: Chest
Vincent C H Chung, Xinyin Wu, Polly H X Ma, Robin S T Ho, Simon K Poon, David S Hui, Samuel Y S Wong, Justin C Y Wu
Among Chinese populations worldwide, Chinese herbal medicines (CHMs) are often used as an adjunct to pharmacotherapy in managing chronic obstructive pulmonary disease (COPD). However, the relative performance among different CHM is unknown.The aim of this study was to evaluate comparative effectiveness of different CHM when used with salmeterol and fluticasone propionate (SFP), compared with SFP alone.This study is a systematic review of randomized controlled trials (RCTs) with network meta-analyses (NMAs)...
May 2016: Medicine (Baltimore)
Annika Karch, Claus Vogelmeier, Tobias Welte, Robert Bals, Hans-Ulrich Kauczor, Jürgen Biederer, Joachim Heinrich, Holger Schulz, Sven Gläser, Rolf Holle, Henrik Watz, Stephanie Korn, Nina Adaskina, Frank Biertz, Charlotte Vogel, Jørgen Vestbo, Emiel F M Wouters, Klaus Friedrich Rabe, Sandra Söhler, Armin Koch, Rudolf A Jörres
BACKGROUND: The German COPD cohort study COSYCONET ("COPD and SYstemic consequences-COmorbidities NETwork") investigates the interaction of lung disease, comorbidities and systemic inflammation. Recruitment took place from 2010 to 2013 in 31 study centers. In addition to the baseline visit, follow-up visits are scheduled at 6, 18, 36 and 54 months after baseline. The study also comprises a biobank, image bank, and includes health economic data. Here we describe the study design of COSYCONET and present baseline data of our COPD cohort...
May 2016: Respiratory Medicine
Rebecca L Kusko, John F Brothers Ii, John Tedrow, Kusum Pandit, Luai Huleihel, Catalina Perdomo, Gang Liu, Brenda Juan-Guardela, Daniel Kass, Sherry Zhang, Marc Lenburg, Fernando Martinez, John Quackenbush, Frank Sciurba, Andrew Limper, Mark Geraci, Ivana Yang, David A Schwartz, Jennifer Beane, Avrum Spira, Naftali Kaminski
RATIONALE: Despite shared environmental exposures, IPF and COPD are usually studied in isolation and the presence of shared molecular mechanisms is unknown. OBJECTIVES: We applied an integrative genomic approach to identify convergent transcriptomic pathways in emphysema and idiopathic pulmonary fibrosis (IPF). METHODS: We defined the transcriptional repertoire of COPD, IPF or normal histology lungs using RNA-seq (n=87). MEASUREMENTS AND MAIN RESULTS: Genes increased in both emphysema and IPF relative to control were enriched for the p53/hypoxia pathway, a finding confirmed in an independent cohort using both gene expression arrays and the nCounter Analysis System (n=193)...
April 22, 2016: American Journal of Respiratory and Critical Care Medicine
Manal S Fawzy, Mohammad H Hussein, Eman Z Abdelaziz, Hussain A Yamany, Hussein M Ismail, Eman A Toraih
Chronic obstructive pulmonary disease (COPD) is a multifactorial chronic respiratory disease, characterized by an obstructive pattern. Understanding the genetic predisposition of COPD is essential to develop personalized treatment regimens. MicroRNAs (miRNAs) are small, endogenous, non-coding RNAs that modulate the expression levels of specific proteins based on sequence complementarity with their target mRNA molecules. Emerging evidences demonstrated the potential use of miRNAs as a disease biomarker. This pilot study aimed to investigate the association of the MIR-196a2 rs11614913 (C/T) polymorphism with COPD susceptibility, the clinical outcome and bronchodilator response to short-acting β2-agonist...
2016: PloS One
Peng Zhao, Liping Yang, Jiansheng Li, Ya Li, Yange Tian, Suyun Li
Bufei Jianpi formula (BJF) has long been used as a therapeutic agent in the treatment of COPD. Systems pharmacology identified 145 active compounds and 175 potential targets of BJF in a previous study. Additionally, BJF was previously shown to effectively prevent COPD and its comorbidities, such as ventricular hypertrophy, by inhibition of inflammatory cytokine production, matrix metalloproteinases expression, and other cytokine production, in vivo. However, the system-level mechanism of BJF for the treatment of COPD is still unclear...
2016: International Journal of Chronic Obstructive Pulmonary Disease
Elaine Yip, Sahar Karimi, Linda T Pien
BACKGROUND: Combination treatment with an inhaled corticosteroid and long-acting beta2-agonist is among the many treatment options for chronic obstructive pulmonary disease (COPD) that has been shown to improve clinical outcomes. While mometasone/formoterol does not currently have an FDA-approved indication for COPD, evidence from 2 phase 3 trials demonstrated that mometasone/formoterol can improve lung function and was well tolerated in patients with moderate-to-very severe COPD. Based on these data, a therapeutic interchange was implemented in the Kaiser Permanente Mid-Atlantic States region to convert patients with a COPD diagnosis from fluticasone/salmeterol to mometasone/formoterol...
April 2016: Journal of Managed Care & Specialty Pharmacy
Birendra Singh, Maria Alvarado-Kristensson, Martin Johansson, Oskar Hallgren, Gunilla Westergren-Thorsson, Matthias Mörgelin, Kristian Riesbeck
UNLABELLED: Moraxella catarrhalis is a human respiratory pathogen that causes acute otitis media in children and is associated with exacerbations in patients suffering from chronic obstructive pulmonary disease (COPD). The first step in M. catarrhalis colonization is adherence to the mucosa, epithelial cells, and extracellular matrix (ECM). The objective of this study was to evaluate the role of M. catarrhalis interactions with collagens from various angles. Clinical isolates (n= 43) were tested for collagen binding, followed by a detailed analysis of protein-protein interactions using recombinantly expressed proteins...
2016: MBio
Zhang Wang, Mona Bafadhel, Koirobi Haldar, Aaron Spivak, David Mayhew, Bruce E Miller, Ruth Tal-Singer, Sebastian L Johnston, Mohammadali Yavari Ramsheh, Michael R Barer, Christopher E Brightling, James R Brown
Increasing evidence suggests that the lung microbiome plays an important role in chronic obstructive pulmonary disease (COPD) severity. However, the dynamics of the lung microbiome during COPD exacerbations and its potential role in disease aetiology remain poorly understood.We completed a longitudinal 16S ribosomal RNA survey of the lung microbiome on 476 sputum samples collected from 87 subjects with COPD at four visits defined as stable state, exacerbation, 2 weeks post-therapy and 6 weeks recovery.Our analysis revealed a dynamic lung microbiota where changes appeared to be associated with exacerbation events and indicative of specific exacerbation phenotypes...
April 2016: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
Joseph S Duffy, Dmitry Tumin, Amy Pope-Harman, Bryan A Whitson, Robert S D Higgins, Don Hayes
Although studies demonstrate that induction therapy improves outcomes after lung transplantation, its influence on survival in patients with chronic obstructive pulmonary disease (COPD) is not clear. The United Network for Organ Sharing database was queried to obtain data regarding adult patients with COPD receiving lung transplant between May 2005 and June 2014. Therapies evaluated include anti-thymocyte globulin, anti-lymphocyte globulin, thymoglobulin, basiliximab, and alemtuzumab. Data were categorized based on receiving induction (INDUCED) and no induction (NONE)...
October 2016: COPD
Jéssica García-Lucio, Gemma Argemi, Olga Tura-Ceide, Marta Diez, Tanja Paul, Cristina Bonjoch, Nuria Coll-Bonfill, Isabel Blanco, Joan A Barberà, Melina M Musri, Victor I Peinado
Pulmonary vessel remodeling in chronic obstructive pulmonary disease (COPD) involves changes in smooth muscle cell proliferation, which are highly dependent on the coordinated interaction of angiogenic-related growth factors. The purpose of the study was to investigate, in isolated pulmonary arteries (PA) from patients with COPD, the gene expression of 46 genes known to be modulators of the angiogenic process and/or involved in smooth muscle cell proliferation and to relate it to vascular remodeling. PA segments were isolated from 29 patients and classified into tertiles, according to intimal thickness...
April 1, 2016: American Journal of Physiology. Lung Cellular and Molecular Physiology
Christopher Davis, Khadija Sheikh, Damien Pike, Sarah Svenningsen, David G McCormack, Denis O'Donnell, J Alberto Neder, Grace Parraga
RATIONALE AND OBJECTIVES: Pulmonary functional magnetic resonance imaging provides a way to quantify ventilation and its heterogeneity-a hallmark finding in chronic obstructive pulmonary disease (COPD). Unfortunately, the etiology and physiological meaning of ventilation defects and their relationship to pulmonary function and symptoms in COPD are not well understood. Another biomarker of ventilation heterogeneity is provided by the "poorly communicating fraction" (PCF), and is calculated as the ratio of total lung capacity to alveolar volume made using whole-body plethysmography...
April 2016: Academic Radiology
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