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https://www.readbyqxmd.com/read/29909373/what-insights-do-patients-and-caregivers-have-on-acute-kidney-injury-and-posthospitalisation-care-a-single-centre-qualitative-study-from-toronto-canada
#1
Samuel A Silver, Marianne Saragosa, Neill K Adhikari, Chaim M Bell, Ziv Harel, Andrea Harvey, Abhijat Kitchlu, Javier A Neyra, Ron Wald, Lianne Jeffs
OBJECTIVES: Hospitalisation with acute kidney injury (AKI) is associated with short-term and long-term adverse events, but patient and caregiver experiences with AKI are not well described. We sought to better understand patient and caregiver perspectives after a hospitalisation with AKI to inform discharge strategies that may improve outcomes for this high-risk population. DESIGN: Qualitative study with semistructured interviews. SETTING: Tertiary care hospital in Toronto, Ontario, Canada...
June 15, 2018: BMJ Open
https://www.readbyqxmd.com/read/29909344/involvement-of-the-tgf%C3%AE-1-ilk-akt-signaling-pathway-in-the-effects-of-hesperidin-in-type-2-diabetic-nephropathy
#2
YingHui Zhang, Bing Wang, Feng Guo, ZhiZhen Li, GuiJun Qin
Diabetic nephropathy is one of the manifestations of systemic microangiopathy in diabetes. Hesperetin, a natural flavanone glycoside compound in citrus fruits, has been demonstrated to exert hypoglycemic effects and protect kidney in experimental diabetic animals. The current study was aimed to investigate the mechanisms underlying the hypoglycemic effects of hesperetin in high-fat/streptozocin (STZ)-induced diabetic nephropathy. The results showed that mice in whom hesperetin was administered for 4 weeks attenuated the increased fasting blood glucose and impaired glucose tolerance ability that was observed in high-fat/STZ mice...
June 14, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29909116/altered-microrna-regulation-of-short-chain-fatty-acid-receptors-in-the-hypertensive-kidney-is-normalized-with-hydrogen-sulfide-supplementation
#3
Gregory J Weber, Jaleyea Foster, Sathnur B Pushpakumar, Utpal Sen
Hypertension affects nearly one third of the adult US population and is a significant risk factor for chronic kidney disease (CKD). An expanding body of recent studies indicates that gut microbiome has crucial roles in regulating physiological processes through, among other mechanisms, one mode of short chain fatty acids (SCFA) and their target receptors. In addition, these SCFA receptors are potential targets of regulation by host miRNAs, however, the mechanisms through which this occurs is not clearly defined...
June 14, 2018: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://www.readbyqxmd.com/read/29909004/sglt2-inhibitors-and-the-kidney-effects-and-mechanisms
#4
REVIEW
V Tsimihodimos, T D Filippatos, M S Elisaf
AIMS: Numerous clinical trials have shown that sodium glucose cotransporter 2 (SGLT2) inhibitors exert a favorable effect on the indices of renal function (albuminuria, glomerular filtration rate decline over time) and the incidence of hard renal endpoints such as renal death or time to initiation of renal replacement therapy. MATERIALS AND METHODS: In this review, we describe in detail the evidence regarding the nephroprotective mechanisms of SGLT2 inhibitors and describe the risk factors that may predispose to the development of acute kidney injury in patients receiving these drugs...
June 6, 2018: Diabetes & Metabolic Syndrome
https://www.readbyqxmd.com/read/29908693/collapsing-glomerulopathy-in-lambda-light-chain-amyloidosis-a-report-of-2-cases
#5
Mazdak A Khalighi, Alexander J Gallan, Anthony Chang, Shane M Meehan
Amyloid nephropathy is an uncommon disease that frequently presents with reduced kidney function and proteinuria and, in developed nations, is most often associated with underlying paraproteinemia. The histologic appearance of glomerular amyloid deposition includes mesangial and capillary wall infiltration by an amorphous eosinophilic material, and features of endo- or extracapillary proliferation are not typically seen. Rare cases of crescentic injury have been reported in a subset of patients with amyloid nephropathy, particularly those with amyloid derived from serum amyloid A protein...
June 13, 2018: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
https://www.readbyqxmd.com/read/29908072/glycyrrhizin-has-a-high-likelihood-to-be-a-victim-of-drug-drug-interactions-mediated-by-hepatic-oatp1b1-1b3
#6
Jiajia Dong, Olajide E Olaleye, Rongrong Jiang, Jing Li, Chuang Lu, Feifei Du, Fang Xu, Junling Yang, Fengqing Wang, Weiwei Jia, Chuan Li
BACKGROUND AND PURPOSE: Intravenous glycyrrhizin, having anti-inflammatory and hepatoprotective properties, is incorporated into the management of liver diseases in China. This investigation was designed to elucidate the molecular mechanism underlying hepatobiliary excretion of glycyrrhizin and to investigate its potential for drug-drug interactions on organic anion-transporting polypeptides (OATP)1B. EXPERIMENTAL APPROACH: Human hepatic transporters were characterized for glycyrrhizin at the cellular and vesicular levels and compared with rat hepatic transporters...
June 16, 2018: British Journal of Pharmacology
https://www.readbyqxmd.com/read/29908044/utilization-and-efficacy-of-elbasvir-grazoprevir-for-treating-hepatitis-c-virus-infection-after-liver-transplantation
#7
Satoshi Miuma, Hisamitsu Miyaaki, Akihiko Soyama, Masaaki Hidaka, Mitsuhisa Takatsuki, Hidetaka Shibata, Naota Taura, Susumu Eguchi, Kazuhiko Nakao
AIM: Recently, elbasvir/grazoprevir combination therapy (EBR/GZR therapy) has been reported to have excellent antiviral effects for chronic genotype 1 hepatitis C virus (HCV) infection. However, it has not been recommended for patients with post-liver transplant (LT) HCV re-infections because of a lack of evidence for effectiveness and drug-drug interactions. METHODS: We report the usage of EBR/GZR in five post-LT HCV re-infected patients with the kinetics of renal function and tacrolimus (Tac) trough levels during and after therapy...
June 16, 2018: Hepatology Research: the Official Journal of the Japan Society of Hepatology
https://www.readbyqxmd.com/read/29907458/taci-deletion-protects-against-progressive-murine-lupus-nephritis-induced-by-baff-overexpression
#8
Tanvi Arkatkar, Holly M Jacobs, Samuel W Du, Quan-Zhen Li, Kelly L Hudkins, Charles E Alpers, David J Rawlings, Shaun W Jackson
B cells are known to promote the pathogenesis of systemic lupus erythematosus (SLE) via the production of pathogenic anti-nuclear antibodies. However, the signals required for autoreactive B cell activation and the immune mechanisms whereby B cells impact lupus nephritis pathology remain poorly understood. The B cell survival cytokine B cell activating factor of the TNF Family (BAFF) has been implicated in the pathogenesis of SLE and lupus nephritis in both animal models and human clinical studies. Although the BAFF receptor has been predicted to be the primary BAFF family receptor responsible for BAFF-driven humoral autoimmunity, in the current study we identify a critical role for signals downstream of Transmembrane Activator and CAML Interactor (TACI) in BAFF-dependent lupus nephritis...
June 12, 2018: Kidney International
https://www.readbyqxmd.com/read/29907141/serum-and-urine-fgf23-and-igfbp-7-for-the-prediction-of-acute-kidney-injury-in-critically-ill-children
#9
Zhenjiang Bai, Fang Fang, Zhong Xu, Chunjiu Lu, Xueqin Wang, Jiao Chen, Jian Pan, Jian Wang, Yanhong Li
BACKGROUND: Fibroblast growth factor 23 (FGF23) and insulin-like growth factor binding protein 7 (IGFBP-7) are suggested to be biomarkers for predicting acute kidney injury (AKI). We compared them with proposed AKI biomarker of cystatin C (CysC), and aimed (1) to examine whether concentrations of these biomarkers vary with age, body weight, illness severity assessed by pediatric risk of mortality III score, and kidney function assessed by estimated glomerular filtration rate (eGFR), (2) to determine the association between these biomarkers and AKI, and (3) to evaluate whether these biomarkers could serve as early independent predictors of AKI in critically ill children...
June 15, 2018: BMC Pediatrics
https://www.readbyqxmd.com/read/29907095/a-case-of-immunotactoid-glomerulopathy-with-false-negative-igg-staining
#10
Shuma Hirashio, Takahiro Arima, Ayaka Satoh, Kouichi Mandai, Shigeo Hara, Takao Masaki
BACKGROUND: Immunotactoid glomerulopathy (ITG) is a rare glomerulonephritis characterized by microtubular deposits. Immunofluorescence findings are necessary to differentiate ITG from other proliferative glomerular diseases. The characteristic tubular structure on electron microscopy is essential for a definitive diagnosis, and the diameter of the structure has been traditionally used for differentiating between ITG and other types of glomerulonephritis with organized deposits. In recent years, the disease concept of monoclonal gammopathy of renal significance, which is associated with M protein produced by plasma cell tumors, has been proposed...
June 15, 2018: BMC Nephrology
https://www.readbyqxmd.com/read/29906428/effects-of-coffee-intake-on-incident-chronic-kidney-disease-community-based-prospective-cohort-study
#11
Jong Hyun Jhee, Ki Heon Nam, Seong Yeong An, Min-Uk Cha, Misol Lee, Seohyun Park, Hyoungnae Kim, Hae-Ryong Yun, Youn Kyung Kee, Jung Tak Park, Tae-Ik Chang, Ea Wha Kang, Tae-Hyun Yoo, Shin-Wook Kang, Seung Hyeok Han
BACKGROUND: Drinking coffee can raise public health problems, but the association between coffee and kidney disease is unknown. We studied whether coffee intake can affect the development of chronic kidney disease in the general population. METHODS: We analyzed 8717 subjects with normal renal function recruited from the KoGES cohort. Based on food frequency questionnaire, coffee consumption was categorized into five groups: 0/week, <1 cup/week, 1-6 cups/week, 1 cup/day, and ≥2 cups/day...
June 12, 2018: American Journal of Medicine
https://www.readbyqxmd.com/read/29905987/risk-factors-of-the-clostridium-difficile-infection-in-patients-with-chronic-kidney-disease
#12
Łukasz Lis, Patryk Jerzak, Andrzej Konieczny, Michał Sroka, Barbara Noceń-Rychlewska, Paweł Podgórski, Wojciech Witkiewicz, Zbigniew Hruby
BACKGROUND: Clostridium difficile (C. difficile) is a Gram-positive bacillus responsible for diarrhea and colitis, mainly among hospitalized patients. It is a leading cause of nosocomial infections. OBJECTIVES: The main goal of the study was to assess the risk factors of the C. difficile infection in patients with chronic kidney disease (CKD). MATERIAL AND METHODS: We evaluated the medical records of all patients treated at the Department of Nephrology and Renal Transplantation of the Research and Development Center in the Provincial Specialist Hospital in Wrocław, Poland, between February 2009 and May 2012, who developed diarrhea, abdominal pain and/or fever within 72 h after admission...
June 15, 2018: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/29905848/uraemic-symptom-burden-and-clinical-condition-in-women-and-men-of-%C3%A2-65-years-of-age-with-advanced-chronic-kidney-disease-results-from-the-equal-study
#13
Moniek W M van de Luijtgaarden, Fergus J Caskey, Christoph Wanner, Nicholas C Chesnaye, Maurizio Postorino, Cynthia J Janmaat, Anirudh Rao, Claudia Torino, Marian Klinger, Christiane Drechsler, Olof Heimburger, Maciej Szymczak, Marie Evans, Friedo W Dekker, Kitty J Jager
Background: The epidemiology and prognosis of chronic kidney disease (CKD) differ by sex. We aimed to compare symptom prevalence and the clinical state in women and men of ≥65 years of age with advanced CKD receiving routine nephrology care. Methods: The European QUALity study on treatment in advanced chronic kidney disease (EQUAL) study follows patients from six European countries of ≥65 years of age  years whose estimated glomerular filtration rate (eGFR) dropped to ≤20 mL/min/1...
June 13, 2018: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/29905409/l-fabp-and-il-6-as-markers-of-chronic-kidney-damage-in-children-after-hemolytic-uremic-syndrome
#14
Katarzyna Lipiec, Piotr Adamczyk, Elżbieta Świętochowska, Katarzyna Ziora, Maria Szczepańska
BACKGROUND: Hemolytic-uremic syndrome (HUS) is a form of thrombotic microangiopathy, in the course of which some patients may develop chronic kidney disease (CKD). From a clinical point of view, it is important to search for markers that allow for early identification of patients at risk of a poor prognosis. OBJECTIVES: The study evaluated the serum and urine levels of liver-type fatty acid binding protein (L-FABP) and interleukin 6 (IL-6). MATERIAL AND METHODS: The study was conducted in 29 children with a history of HUS...
June 13, 2018: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/29904998/effect-of-low-carbohydrate-diet-on-markers-of-renal-function-in-patients-with-type-2-diabetes-a-meta-analysis
#15
REVIEW
Perdana Samekto Tyasnugroho Suyoto
Meta-analysis was conducted to clarify the effect of low carbohydrate diet (LCD) on renal function in patients with type 2 diabetes mellitus (T2DM). An extensive literature search was conducted on scientific databases including PubMed, Scopus, and Cochrane Library until September 2017. Only controlled trials on human subjects written in English were included in this meta-analysis. Several markers of renal function were compared between subjects who adopted a LCD or control diet, including estimated glomerular filtration rate (eGFR), creatinine clearance, urinary albumin, serum creatinine, and serum uric acid...
June 14, 2018: Diabetes/metabolism Research and Reviews
https://www.readbyqxmd.com/read/29903748/transethnic-genome-wide-analysis-reveals-immune-related-risk-alleles-and-phenotypic-correlates-in-pediatric-steroid-sensitive-nephrotic-syndrome
#16
Hanna Debiec, Claire Dossier, Eric Letouzé, Christopher E Gillies, Marina Vivarelli, Rosemary K Putler, Elisabet Ars, Evelyne Jacqz-Aigrain, Valery Elie, Manuela Colucci, Stéphanie Debette, Philippe Amouyel, Siham C Elalaoui, Abdelaziz Sefiani, Valérie Dubois, Tabassome Simon, Matthias Kretzler, Jose Ballarin, Francesco Emma, Matthew G Sampson, Georges Deschênes, Pierre Ronco
Background Steroid-sensitive nephrotic syndrome (SSNS) is a childhood disease with unclear pathophysiology and genetic architecture. We investigated the genomic basis of SSNS in children recruited in Europe and the biopsy-based North American NEPTUNE cohort. Methods We performed three ancestry-matched, genome-wide association studies (GWAS) in 273 children with NS (Children Cohort Nephrosis and Virus [NEPHROVIR] cohort: 132 European, 56 African, and 85 Maghrebian) followed by independent replication in 112 European children, transethnic meta-analysis, and conditional analysis...
June 14, 2018: Journal of the American Society of Nephrology: JASN
https://www.readbyqxmd.com/read/29902370/the-instituto-mexicano-del-seguro-social-gives-dialysis-therapies-to-426-students-without-cost
#17
Antonio Méndez-Durán, Manuel Humberto Ignorosa-Luna, Gilberto Pérez-Aguilar, Francisco Jesús Rivera-Rodríguez, Luis Rafael López-Ocaña
Background: The Instituto Mexicano del Seguro Social (IMSS) is the institution with the greatest health coverage in Mexico. In adherence to existing and committed to provide specialized services to specific populations (vulnerable age groups, such as children and young people in primary, secondary and higher education, productive and without social security educational training), this gives the renal replacement therapy -peritoneal dialysis and hemodialysis- at no cost to students. Methods: Cross-sectional and retrospective study conducted from 1 to 30 September 2016; Census Patients with Chronical Renal Failure, sociodemographic and type of therapy are identified; direct costs are estimated...
March 2018: Revista Médica del Instituto Mexicano del Seguro Social
https://www.readbyqxmd.com/read/29901939/correlation-and-concordance-between-the-primary-glomerular-filtration-mdrd-6-and-creatinine-clearance-by-the-conventional-method
#18
Apolonio Aveitua-Guerrero, Leonor Ballesteros-Angeles, María del Carmen López-Parra, Rosario Santos-Barajas
Background: The aim of the study was to determine the correlation and concordance between the primary glomerular filtration rate estimated by the MDRD-6 (Modification of Diet in Renal Disease, (mL/min/1.73 m2) equation and the creatinine clearance in 24-hour urine (DCr.mL/min) by conventional method. Methods: Retrospective, observational and comparative study. We studied 180 patients, were quantified in serum: creatinine (Cr), urea nitrogen (BUN) albumin (Alb) and, in urine for 24 hours: creatinine (Cr)...
March 2018: Revista Médica del Instituto Mexicano del Seguro Social
https://www.readbyqxmd.com/read/29901140/spleen-tyrosine-kinase-promotes-nlr-family-pyrin-domain-containing-3-inflammasome%C3%A2-mediated-il%C3%A2-1%C3%AE-secretion-via-c%C3%A2-jun-n%C3%A2-terminal-kinase-activation-and-cell-apoptosis-during-diabetic-nephropathy
#19
Yingchun Qiao, Xixi Tian, Li Men, Shengyu Li, Yufeng Chen, Meiting Xue, Yahui Hu, Pengfei Zhou, Guangfeng Long, Yue Shi, Ruiqing Liu, Yunde Liu, Zhi Qi, Yujie Cui, Yanna Shen
Diabetic nephropathy (DN) is a serious complication of diabetes and can cause an increased mortality risk. It was previously reported that NLR family pyrin domain containing 3 (NLRP3) inflammasome is involved in the pathogenesis of diabetes. However, the underlying mechanism is not clearly understood. In the present study, the effects of spleen tyrosine kinase (Syk) and c‑Jun N‑terminal kinase (JNK) on the NLRP3 inflammasome were examined in vivo and in vitro. Sprague‑Dawley rats were injected intraperitoneally with streptozotocin (65 mg/kg) to induce diabetes...
June 14, 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29901095/loss-of-klf15-accelerates-chronic-podocyte-injury
#20
Seung Seok Han, Mi-Yeon Yu, Kyung Don Yoo, Jung Pyo Lee, Dong Ki Kim, Yon Su Kim, Seung Hee Yang
Krüppel‑like factor 15 (KLF15), also known as kidney‑enriched transcription factor, is known to participate in podocyte differentiation. However, the role of KLF15 in chronic podocyte injury remains incompletely understood, particularly in proteinuric disease models. In the present study, the 5/6 nephrectomy mouse model was used to induce chronic podocyte injury. Human primary podocytes were isolated by flow cytometry and cultured to emulate the injury process in an in vitro system. Biopsied kidney tissue samples were obtained from patients with primary membranous nephropathy or diabetic nephropathy in order to analyze the relationship between glomerular KLF15 expression and subsequent outcomes...
June 11, 2018: International Journal of Molecular Medicine
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