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https://www.readbyqxmd.com/read/27888619/tetraspanin-cd151-as-an-emerging-potential-poor-prognostic-factor-across-solid-tumors-a-systematic-review-and-meta-analysis
#1
REVIEW
Ping Zeng, Yin-Hua Wang, Meng Si, Jin-Hua Gu, Ping Li, Pei-Hua Lu, Min-Bin Chen
Tetraspanin CD151, also known as PETA-3 or SFA-1, has been reported to predict prognosis in various solid tumors. Yet, the results of these studies remained inconclusive. Here, we performed this meta-analysis of relevant studies published on the topic to quantitatively evaluate the clinicopathological significance of CD151 in solid tumors. The relevant articles were identified via searching the PubMed, Web of Science and Embase database. The pooled hazard ratios (HRs) and corresponding 95% confidence intervals (CI) of overall survival (OS) and disease-free survival (DFS) were calculated to evaluate the prognostic value of CD151 expression in patients with solid tumors...
November 23, 2016: Oncotarget
https://www.readbyqxmd.com/read/27599545/anti-invasion-and-anti-migration-effects-of-mir-199a-3p-in-hepatocellular-carcinoma-are-due-in-part-to-targeting-cd151
#2
Ji Hye Kim, Mohamed Badawi, Jong-Kook Park, Jinmai Jiang, Xiaokui Mo, Lewis R Roberts, Thomas D Schmittgen
Several studies have reported reduced miR-199a-3p expression in hepatocellular carcinoma (HCC). In an effort to discover important target genes for miR-199a-3p that may be related to HCC development or progression, we identified the tetraspanin, transmembrane glycoprotein CD151. Luciferase reporter assays and western blotting identified CD151 as a bona fide miR-199a-3p target gene. While CD151 protein was increased in the mesenchymal but not the epithelial HCC cell lines, CD151 knockdown with siRNA did not reduce HCC cell proliferation in either group of cells...
September 2, 2016: International Journal of Oncology
https://www.readbyqxmd.com/read/27577713/cd151-gene-and-protein-expression-provides-independent-prognostic-information-for-patients-with-adenocarcinoma-of-the-esophagus-and-gastroesophageal-junction-treated-by-esophagectomy
#3
Oliver M Fisher, Angelique J Levert-Mignon, Christopher W Lehane, Natalia K Botelho, Jesper L V Maag, Melissa L Thomas, Melanie Edwards, Sarah J Lord, Yuri V Bobryshev, David C Whiteman, Reginald V Lord
BACKGROUND: Esophageal and gastroesophageal junctional (GEJ) adenocarcinoma is one of the most fatal cancers and has the fastest rising incidence rate of all cancers. Identification of biomarkers is needed to tailor treatments to each patient's tumor biology and prognosis. METHODS: Gene expression profiling was performed in a test cohort of 80 chemoradiotherapy (CRTx)-naïve patients with external validation in a separate cohort of 62 CRTx-naïve patients and 169 patients with advanced-stage disease treated with CRTx...
August 30, 2016: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/27558487/cd151-mediates-netrin-1-induced-angiogenesis-through-the-src-fak-paxillin-pathway
#4
Xiaosheng Yang, Shiting Li, Jun Zhong, Wenchuan Zhang, Xuming Hua, Bin Li, Hui Sun
Crosstalk between the nervous and vascular systems is important during development and in response to injury, and the laminin-like axonal guidance protein netrin-1 has been studied for its involvement in angiogenesis and vascular remodelling. In this study, we examined the role of netrin-1 in angiogenesis and explored the underlying mechanisms. The effect of netrin-1 on brain tissues and endothelial cells was examined by immunohistochemistry and western blotting in a middle cerebral artery occlusion model and in human umbilical vein endothelial cells...
August 25, 2016: Journal of Cellular and Molecular Medicine
https://www.readbyqxmd.com/read/27556355/cd151-mediated-adhesion-is-crucial-to-osteosarcoma-pulmonary-metastasis
#5
Zhuoying Wang, Chongren Wang, Zifei Zhou, Mengxiong Sun, Chenghao Zhou, Jian Chen, Fei Yin, Hongsheng Wang, Binhui Lin, Dongqing Zuo, Suoyuan Li, Lijin Feng, Zhenfeng Duan, Zhengdong Cai, Yingqi Hua
CD151, a tetraspanin family protein involved in cell-cell and cell-extracellular matrix interaction, is differentially expressed in osteosarcoma cell membranes. Thus, this study aimed to investigate the role of CD151 in osteosarcoma metastasis. We analyzed CD151 expression in patient tissue samples using immunohistochemistry. CD151 expression was also silenced with shRNA in osteosarcoma cells of high metastatic potential, and cell adhesion, migration and invasion were evaluated in vitro and pulmonary metastasis was investigated in vivo...
August 19, 2016: Oncotarget
https://www.readbyqxmd.com/read/27522674/delivery-of-cd151-by-ultrasound-microbubbles-in-rabbit-myocardial-infarction
#6
Shao-Ling Yang, Ke-Qiang Tang, Jun-Jia Tao, Ai-Hong Wan, Yan-Duan Lin, Shu-Liang Nan, Qing-Kui Guo, Zhi Yong Shen, Bin Hu
OBJECTIVES: We aimed to evaluate whether ultrasound (US) and microbubble-mediated delivery of Cluster of Differentiation 151 (CD151) could enhance the therapeutic effects of CD151 on myocardial infarction (MI). METHODS: A rabbit model of MI was established by a modified Fujita method. Then, 50 MI rabbits were randomly divided into 5 groups, including G1 (CD151 plasmid and physiological saline in the presence of US); G2 (CD151 and Sonovue in the presence of US); G3 (CD151 and Sonovue in the absence of US); G4 (Sonovue in the absence of US), and a control group (physiological saline in the absence of US)...
August 13, 2016: Cardiology
https://www.readbyqxmd.com/read/27444451/cd151-expression-is-frequent-but-unrelated-to-clinical-outcome-in-head-and-neck-cancer
#7
Julie C Nienstedt, Alexander Gröbe, Patrick Lebok, Franziska Büscheck, Till Clauditz, Ronald Simon, Asmus Heumann, Guido Sauter, Christoph Moebius, Adrian Münscher, Rainald Knecht, Marco Blessmann, Max Heiland, Christina Pflug
OBJECTIVES: CD151 is a plasma membrane protein belonging to the tetraspanin family. CD151 represents a putative therapeutic target and has been suggested as a prognostic marker in several cancer types. The present study aims to investigate the prognostic relevance of immunohistochemical CD151 expression in head and neck squamous cell carcinoma (HNSCC). MATERIALS AND METHODS: Tissue microarray (TMA) sections containing samples from 667 cancers of oral cavity, oro- and hypopharynx and larynx, for which follow-up data were available, were analyzed for CD151 expression by immunohistochemistry...
July 21, 2016: Clinical Oral Investigations
https://www.readbyqxmd.com/read/27401149/novel-fusion-genes-and-chimeric-transcripts-in-ependymal-tumors
#8
Thale Kristin Olsen, Ioannis Panagopoulos, Ludmila Gorunova, Francesca Micci, Kristin Andersen, Hege Kilen Andersen, Torstein R Meling, Bernt Due-Tønnessen, David Scheie, Sverre Heim, Petter Brandal
We have previously identified two ALK rearrangements in a subset of ependymal tumors using a combination of cytogenetic data and RNA sequencing. The aim of the present study was to perform an unbiased search for fusion transcripts in our entire series of ependymal tumors. Fusion analysis was performed using the FusionCatcher algorithm on 12 RNA-sequenced ependymal tumors. Candidate transcripts were prioritized based on the software's filtering and manual visualization using the BLAST (Basic Local Alignment Search Tool) and BLAT (BLAST-like alignment tool) tools...
July 12, 2016: Genes, Chromosomes & Cancer
https://www.readbyqxmd.com/read/27343445/exosomal-proteins-as-diagnostic-biomarkers-in%C3%A2-lung%C3%A2-cancer
#9
Birgitte Sandfeld-Paulsen, Kristine Raaby Jakobsen, Rikke Bæk, Birgitte Holst Folkersen, Torben Riis Rasmussen, Peter Meldgaard, Kim Varming, Malene Møller Jørgensen, Boe Sandahl Sorensen
INTRODUCTION: Exosomes have been suggested as promising biomarkers in NSCLC because they contain proteins from their originating cells and are readily available in plasma. In this study, we explored the potential of exosome protein profiling in diagnosing lung cancers of all stages and various histological subtypes in patients. METHODS: Plasma was isolated from 581 patients (431 with lung cancer and 150 controls). The extracellular vesicle array was used to phenotype exosomes...
October 2016: Journal of Thoracic Oncology
https://www.readbyqxmd.com/read/27270320/pik3c2a-mrna-functions-as-a-mir-124-sponge-to-facilitate-cd151-expression-and-enhance-malignancy-of-hepatocellular-carcinoma-cells
#10
Tao Liu, Cai-Hua Zu, Shu-Sen Wang, Hong-Li Song, Zheng-Lu Wang, Xin-Nv Xu, Hong-Sheng Liu, Yu-Liang Wang, Zhong-Yang Shen
Competing endogenous RNAs (ceRNAs) are RNA transcripts that can crosstalk with each other by competing for shared microRNAs (miRNAs) through miRNA response elements (MREs). Involved in ceRNA networks, the RNA transcripts may be in a balance, disruption of which could lead to tumorigenesis. Here we reveal a ceRNA interaction between PIK3C2A and CD151 mRNAs in hepatocellular carcinoma (HCC) cells. PIK3C2A is a candidate ceRNA of CD151 because mRNA 3' untranslated regions (3'UTRs) of these two genes contain miR-124 binding sites...
May 30, 2016: Oncotarget
https://www.readbyqxmd.com/read/27243007/tetraspanins-and-transmembrane-adaptor-proteins-as-plasma-membrane-organizers-mast-cell-case
#11
REVIEW
Ivana Halova, Petr Draber
The plasma membrane contains diverse and specialized membrane domains, which include tetraspanin-enriched domains (TEMs) and transmembrane adaptor protein (TRAP)-enriched domains. Recent biophysical, microscopic, and functional studies indicated that TEMs and TRAP-enriched domains are involved in compartmentalization of physicochemical events of such important processes as immunoreceptor signal transduction and chemotaxis. Moreover, there is evidence of a cross-talk between TEMs and TRAP-enriched domains. In this review we discuss the presence and function of such domains and their crosstalk using mast cells as a model...
2016: Frontiers in Cell and Developmental Biology
https://www.readbyqxmd.com/read/27233153/cd151-a-laminin-receptor-showing-increased-expression-in-asthmatic-patients-contributes-to-airway-hyperresponsiveness-through-calcium-signaling
#12
Yongkang Qiao, John Kit Chung Tam, Sheryl S L Tan, Yee Kit Tai, Chin Yein Chin, Alastair G Stewart, Leonie Ashman, Kiyotoshi Sekiguchi, Shenna Y Langenbach, Gerald Stelmack, Andrew J Halayko, Thai Tran
BACKGROUND: Airway smooth muscle (ASM) contraction underpins airway constriction; however, underlying mechanisms for airway hyperresponsiveness (AHR) remain incompletely defined. CD151, a 4-transmembrane glycoprotein that associates with laminin-binding integrins, is highly expressed in the human lung. The role of CD151 in ASM function and its relationship to asthma have yet to be elucidated. OBJECTIVE: We sought to ascertain whether CD151 expression is clinically relevant to asthma and whether CD151 expression affects AHR...
April 27, 2016: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/27182980/developing-a-triple-transgenic-cell-line-for-high-efficiency-porcine-reproductive-and-respiratory-syndrome-virus-infection
#13
Linlin Zhang, Zhengzhi Cui, Lei Zhou, Youmin Kang, Li Li, Jinxiu Li, Yunping Dai, Shuyang Yu, Ning Li
Porcine reproductive and respiratory syndrome virus (PRRSV) is one of the most devastating pathogens in the swine industry worldwide. Due to the lack of robust cell lines and small animal models, the pathogenesis of PRRSV infection and mechanism for protective vaccination are still not yet well understood. To obtain useful cell lines, several groups have attempted to construct different transgenic cell lines with three PRRSV receptors: CD163, CD169, and CD151. The results showed that CD163 is essential for PRRSV entry into target cells and replication, and both CD169 and CD151 play key roles during PRRSV infection...
2016: PloS One
https://www.readbyqxmd.com/read/27147745/tetraspanin-cd151-promotes-initial-events-in-human-cytomegalovirus-infection
#14
Daniel Hochdorfer, Luise Florin, Christian Sinzger, Diana Lieber
UNLABELLED: Human cytomegalovirus (HCMV), a betaherpesvirus, can cause life-threatening disease in immunocompromised individuals. Viral envelope glycoproteins that mediate binding to and penetration into target cells have been identified previously. In contrast, cellular proteins supporting HCMV during entry are largely unknown. In order to systematically identify host genes affecting initial steps of HCMV infection, a targeted RNA interference screen of 96 cellular genes was performed in endothelial cells by use of a virus strain expressing the full set of known glycoprotein H and L (gH/gL) complexes...
July 15, 2016: Journal of Virology
https://www.readbyqxmd.com/read/27130570/autologous-chondrocytes-as-a-novel-source-for-neo-chondrogenesis-in-haemophiliacs
#15
Elena Stocco, Silvia Barbon, Paolo Radossi, Senthilkumar Rajendran, Daniele Dalzoppo, Marina Bortolami, Andrea Bagno, Francesca Grandi, Pier Giorgio Gamba, Pier Paolo Parnigotto, Giuseppe Tagariello, Claudio Grandi
Haemophilic arthropathy is the major cause of disability in patients with haemophilia and, despite prophylaxis with coagulation factor concentrates, some patients still develop articular complications. We evaluate the feasibility of a tissue engineering approach to improve current clinical strategies for cartilage regeneration in haemophiliacs by using autologous chondrocytes (haemophilic chondrocytes; HaeCs). Little is known about articular chondrocytes from haemophilic patients and no characterisation has as yet been performed...
October 2016: Cell and Tissue Research
https://www.readbyqxmd.com/read/27107458/elevated-integrin-%C3%AE-6%C3%AE-4-expression-is-associated-with-venous-invasion-and-decreased-overall-survival-in-non-small-cell-lung-cancer
#16
Rachel L Stewart, Dava West, Chi Wang, Heidi L Weiss, Tamas Gal, Eric B Durbin, William O'Connor, Min Chen, Kathleen L O'Connor
Lung cancer carries a poor prognosis and is the most common cause of cancer-related death worldwide. The integrin α6β4, a laminin receptor, promotes carcinoma progression in part by cooperating with various growth factor receptors to facilitate invasion and metastasis. In carcinoma cells with mutant TP53, the integrin α6β4 promotes cell survival. TP53 mutations and integrin α6β4 overexpression co-occur in many aggressive malignancies. Because of the high frequency of TP53 mutations in lung squamous cell carcinoma (SCC), we sought to investigate the association of integrin β4 expression with clinicopathologic features and survival in non-small cell lung cancer (NSCLC)...
August 2016: Human Pathology
https://www.readbyqxmd.com/read/26992919/regulation-of-glioblastoma-tumor-propagating-cells-by-the-integrin-partner-tetraspanin-cd151
#17
Jessica Tilghman, Paula Schiapparelli, Bachuchu Lal, Mingyao Ying, Alfredo Quinones-Hinojosa, Shuli Xia, John Laterra
Glioblastoma (GBM) stem cells (GSCs) represent tumor-propagating cells with stem-like characteristics (stemness) that contribute disproportionately to GBM drug resistance and tumor recurrence. Understanding the mechanisms supporting GSC stemness is important for developing therapeutic strategies for targeting GSC-dependent oncogenic mechanisms. Using GBM-derived neurospheres, we identified the cell surface tetraspanin family member CD151 as a novel regulator of glioma cell stemness, GSC self-renewal capacity, migration, and tumor growth...
March 2016: Neoplasia: An International Journal for Oncology Research
https://www.readbyqxmd.com/read/26707073/cd151-knockdown-inhibits-osteosarcoma-metastasis-through-the-gsk-3%C3%AE-%C3%AE-catenin-mmp9-pathway
#18
Zhiyu Zhang, Feng Wang, Qin Li, Haifei Zhang, Yan Cui, Chengbin Ma, Jiajun Zhu, Xueyuan Gu, Zhenguo Sun
Osteosarcoma (OS) is a primary bone malignancy with a high early metastatic propensity. It is crucial to find specific protein targets to develop therapeutic strategies against this lethal disease. Tetraspanin CD151 is involved in facilitating tumor metastasis. However, the role and molecular mechanism of CD151 in promoting OS metastasis remain enigmatic. In the present study, we used small interfering RNA (siRNA) to inhibit CD151 expression in highly metastatic OS cells and the results demonstrated that CD151 knockdown inhibited their migration, invasion and metastasis...
March 2016: Oncology Reports
https://www.readbyqxmd.com/read/26562164/homozygous-loss-of-mouse-tetraspanin-cd82-enhances-integrin-%C3%AE-iib%C3%AE-3-expression-and-clot-retraction-in-platelets
#19
Kristen Uchtmann, Electa R Park, Alexis Bergsma, Justin Segula, Mathew J Edick, Cindy K Miranti
Integrin αIIbβ3 is critical for platelet-mediated blood clotting. Tetraspanins are well-established regulators of integrins and genetic loss of tetraspanin CD151 or TSSC6 in mice leads to increased bleeding due to inadequate integrin αIIbβ3 outside-in signaling. Conversely, mild but enhanced integrin αIIbβ3 activation and hyperaggregation is observed in CD9 and CD63 null mice respectively. CD82 is reportedly expressed in platelets; however its function is unknown. Using genetically engineered CD82 null mice, we investigated the role of the tetraspanin CD82 in platelet activation...
December 10, 2015: Experimental Cell Research
https://www.readbyqxmd.com/read/26529559/cd151-regulates-t-cell-migration-in-health-and-inflammatory-bowel-disease
#20
COMPARATIVE STUDY
Einat Zelman-Toister, Eszter Bakos, Sivan Cohen, Ehud Zigmond, Elias Shezen, Valentin Grabovsky, Adi Sagiv, Gili Hart, Nathali Kaushansky, Avi Ben-Nun, Nitsan Maharshak, Arnoud Sonnenberg, Ronen Alon, Shirly Becker-Herman, Idit Shachar
The continuous recirculation of mature lymphocytes and their entry into the peripheral lymph nodes are crucial for the development of an immune response to foreign antigens. Occasionally, the entry and the subsequent response of T lymphocytes in these sites lead to severe inflammation and pathological conditions. Here, we characterized the tetraspanin molecule, CD151, as a regulator of T cell motility in health and in models of inflammatory bowel disease. CD151 formed a cell surface complex with VLA-4 and LFA-1 integrins, and its activation led to enhanced migration of T cells...
February 2016: Inflammatory Bowel Diseases
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