keyword
MENU ▼
Read by QxMD icon Read
search

"Memory dysfunction"

keyword
https://www.readbyqxmd.com/read/29322860/antenatal-and-neonatal-antecedents-of-executive-dysfunctions-in-extremely-preterm-children
#1
Alan Leviton, Robert M Joseph, Elizabeth N Allred, T Michael O'Shea, H Gerry Taylor, Karl K C Kuban
To find out why children born extremely preterm are at heightened risk of executive dysfunctions, the authors assessed 716 children who were 10 years old born extremely preterm whose IQ was ≥ 70. A working memory dysfunction (n = 169), an inhibition dysfunction (n = 360), a switching dysfunction (355), and all 3 (executive dysfunction; n = 107) were defined on the basis of Z-scores ≤ -1 on the Differential Ability Scales-II Working Memory composite, and/or on the NEPSY-II Inhibition-Inhibition and Inhibition-Switching subtests...
January 1, 2018: Journal of Child Neurology
https://www.readbyqxmd.com/read/29285280/altered-network-efficiency-of-functional-brain-networks-in-patients-with-breast-cancer-after-chemotherapy
#2
Han Xuan, Chen Gan, Wen Li, Zhonglian Huang, Longsheng Wang, Qianqian Jia, Zhendong Chen, Huaidong Cheng
Objective: To investigate the topological organization of functional brain networks in chemotherapy-treated breast cancer (BC) patients with source memory impairment. Methods: Twenty-eight patients with BCfollowingchemotherapyand40age-and education-matched healthy controls (HCs) were recruited in the current study. All participants underwent source memory tests and resting-state functional MRI scans. Individual whole-brain functional brain networks were constructed and analyzed using graph-based network approaches...
December 1, 2017: Oncotarget
https://www.readbyqxmd.com/read/29277405/transcranial-magnetic-stimulation-of-the-precuneus-enhances-memory-and-neural-activity-in-prodromal-alzheimer-s-disease
#3
Giacomo Koch, Sonia Bonnì, Maria Concetta Pellicciari, Elias P Casula, Matteo Mancini, Romina Esposito, Viviana Ponzo, Silvia Picazio, Francesco Di Lorenzo, Laura Serra, Caterina Motta, Michele Maiella, Camillo Marra, Mara Cercignani, Alessandro Martorana, Carlo Caltagirone, Marco Bozzali
Memory loss is one of the first symptoms of typical Alzheimer's disease (AD), for which there are no effective therapies available. The precuneus (PC) has been recently emphasized as a key area for the memory impairment observed in early AD, likely due to disconnection mechanisms within large-scale networks such as the default mode network (DMN). Using a multimodal approach we investigated in a two-week, randomized, sham-controlled, double-blinded trial the effects of high-frequency repetitive transcranial magnetic stimulation (rTMS) of the PC on cognition, as measured by the Alzheimer Disease Cooperative Study Preclinical Alzheimer Cognitive Composite in 14 patients with early AD (7 females)...
December 19, 2017: NeuroImage
https://www.readbyqxmd.com/read/29238386/optimized-sopungsunkiwon-a-herbal-formula-attenuates-a%C3%AE-oligomer-induced-neurotoxicity-in-alzheimer-s-disease-models
#4
Jin Gyu Choi, Sun Yeou Kim, Jong Woo Kim, Myung Sook Oh
Alzheimer's disease (AD), the most common form of dementia, is an age-related neurodegenerative disease that is characterized by memory dysfunction, neuronal cell damage, and neuroinflammation. It is believed that AD-related pathology is mostly due to the overproduction of Aβ, especially the oligomeric form (AβO), in the brain. Evidence of the effects of multifunctional medicinal herbs in the treatment of AD has been steadily increasing. Optimized-SopungSunkiwon (OSS), a multiherbal formulation that is composed of six medicinal herbs derived from SopungSunkiwon, is a traditional medicine that is prescribed for neurodegenerative disorders in elderly patients...
2017: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/29232539/how-to-identify-and-manage-cognitive-dysfunction-after-breast-cancer-treatment
#5
Marie Lange, Florence Joly
Attention and memory dysfunction is a common complaint among patients with breast cancer that can be reported during and up to several years after treatment. It can negatively affect patients' quality of life and their ability to work. This phenomenon has mainly been studied in patients with breast cancer who are treated with adjuvant chemotherapy. Women describe concentration problems and difficulties with word finding, multitasking, or remembering new information, as well as more effort and time needed to accomplish these tasks...
December 2017: Journal of Oncology Practice
https://www.readbyqxmd.com/read/29214892/rutin-hydrate-ameliorates-cadmium-chloride-induced-spatial-memory-loss-and-neural-apoptosis-in-rats-by-enhancing-levels-of-acetylcholine-inhibiting-jnk-and-erk1-2-activation-and-activating-mtor-signalling
#6
Ghada A Abdel-Aleem, Eman F Khaleel
This study aimed at studying the potential neuroprotective effect of Rutin hydrate (RH) alone or in conjugation with α-tocopherol against cadmium chloride (CdCl2)-induced neurotoxicity and cognitive impairment in rats and to investigate the mechanisms of action. Rats intoxicated with CdCl2 were treated with the vehicle, RH, α-tocopherol or combined treatment were examined, and compared to control rats received vehicle or individual doses of either drug. Data confirmed that RH improves spatial memory function by increasing acetylcholine availability, boosting endogenous antioxidant potential, activating cell survival and inhibiting apoptotic pathways, an effect that is more effective when RH was conjugated with α-tocopherol...
December 7, 2017: Archives of Physiology and Biochemistry
https://www.readbyqxmd.com/read/29199131/combined-therapy-involving-electroacupuncture-and-treadmill-exercise-attenuates-demyelination-in-the-corpus-callosum-by-stimulating-oligodendrogenesis-in-a-rat-model-of-neonatal-hypoxia-ischemia
#7
Malk Eun Pak, Da Hee Jung, Hong Ju Lee, Myung Jun Shin, Soo-Yeon Kim, Yong Beom Shin, Young Ju Yun, Hwa Kyoung Shin, Byung Tae Choi
We investigated whether electroacupuncture (EA) and treadmill (TM) exercise improve behaviors related to motor and memory dysfunction in a cerebral palsy-like rat model via activation of oligodendrogenesis. A neonatal hypoxia-ischemia model was created using Sprague-Dawley rats (P7), and these underwent EA stimulation and treadmill training from 3 to 5weeks after hypoxia-ischemia induction. EA treatment was delivered via electrical stimulation (2Hz, 1mA) at two acupoints, Baihui (GV20) and Zusanli (ST36). Behavioral tests showed that EA alleviated motor dysfunction caused by hypoxia-ischemia on a rotarod test, and TM exercise alleviated motor and memory dysfunction seen on cylinder and passive avoidance tests...
February 2018: Experimental Neurology
https://www.readbyqxmd.com/read/29180982/resveratrol-for-easing-status-epilepticus-induced-brain-injury-inflammation-epileptogenesis-and-cognitive-and-memory-dysfunction-are-we-there-yet
#8
REVIEW
Olagide W Castro, Dinesh Upadhya, Maheedhar Kodali, Ashok K Shetty
Status epilepticus (SE) is a medical emergency exemplified by self-sustaining, unceasing seizures or swiftly recurring seizure events with no recovery between seizures. The early phase after SE event is associated with neurodegeneration, neuroinflammation, and abnormal neurogenesis in the hippocampus though the extent of these changes depends on the severity and duration of seizures. In many instances, over a period, the initial precipitating injury caused by SE leads to temporal lobe epilepsy (TLE), typified by spontaneous recurrent seizures, cognitive, memory and mood impairments associated with chronic inflammation, reduced neurogenesis, abnormal synaptic reorganization, and multiple molecular changes in the hippocampus...
2017: Frontiers in Neurology
https://www.readbyqxmd.com/read/29179727/mild-endoplasmic-reticulum-stress-ameliorates-lipopolysaccharide-induced-neuroinflammation-and-cognitive-impairment-via-regulation-of-microglial-polarization
#9
Yi-Wei Wang, Qin Zhou, Xiang Zhang, Qing-Qing Qian, Jia-Wen Xu, Peng-Fei Ni, Yan-Ning Qian
BACKGROUND: Neuroinflammation, which ultimately leads to neuronal loss, is considered to play a crucial role in numerous neurodegenerative diseases. The neuroinflammatory process is characterized by the activation of glial cells such as microglia. Endoplasmic reticulum (ER) stress is commonly associated with impairments in neuronal function and cognition, but its relationship and role in neurodegeneration is still controversial. Recently, it was confirmed that nonharmful levels of ER stress protected against experimental Parkinson's disease...
November 28, 2017: Journal of Neuroinflammation
https://www.readbyqxmd.com/read/29175709/alpha7-nicotinic-acetylcholine-receptor-specific-agonist-dmxba-gts-21-attenuates-a%C3%AE-accumulation-through-suppression-of-neuronal-%C3%AE-secretase-activity-and-promotion-of-microglial-amyloid-%C3%AE-phagocytosis-and-ameliorates-cognitive-impairment-in-a-mouse-model-of
#10
Kazuyuki Takata, Takahide Amamiya, Hiroaki Mizoguchi, Shohei Kawanishi, Eriko Kuroda, Risa Kitamura, Aina Ito, Yuki Saito, Manami Tawa, Tomofumi Nagasawa, Haruka Okamoto, Yuko Sugino, Shigehiko Takegami, Tatsuya Kitade, Yuki Toda, William R Kem, Yoshihisa Kitamura, Shun Shimohama, Eishi Ashihara
We previously demonstrated that stimulation of nicotinic acetylcholine receptors (nAChRs) increases amyloid-β (Aβ) phagocytosis in rat microglia and is closely associated with the decrease of brain Aβ and amelioration of memory dysfunction in a transgenic mouse model of Alzheimer's disease (AD). Here, we examined the subtypes of nAChRs involved in these beneficial effects. In primary cultures of rat microglia, the α7 nAChR selective agonist 3-[(2,4-dimethoxy)benzylidene]-anabaseine dihydrochloride (DMXBA) promoted Aβ and fluorescent latex bead phagocytosis, whereas selective α7 nAChR antagonists suppressed the enhanced Aβ phagocytosis...
February 2018: Neurobiology of Aging
https://www.readbyqxmd.com/read/29172002/mental-states-in-moving-shapes-distinct%C3%A2-cortical-and-subcortical-contributions-to-theory-of-mind-impairments-in-dementia
#11
Artemis Synn, Annu Mothakunnel, Fiona Kumfor, Yu Chen, Olivier Piguet, John R Hodges, Muireann Irish
Impaired capacity for Theory of Mind (ToM) represents one of the hallmark features of the behavioral variant of frontotemporal dementia (bvFTD) and is suggested to underpin an array of socioemotional disturbances characteristic of this disorder. In contrast, while social processing typically remains intact in Alzheimer's disease (AD), the cognitive loading of socioemotional tasks may adversely impact mentalizing performance in AD. Here, we employed the Frith-Happé animations as a dynamic on-line assessment of mentalizing capacity with reduced incidental task demands in 18 bvFTD, 18 AD, and 25 age-matched Controls...
November 20, 2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/29171599/ginger-fermented-with-schizosaccharomyces-pombe-alleviates-memory-impairment-via-protecting-hippocampal-neuronal-cells-in-amyloid-beta1-42-plaque-injected-mice
#12
Eugene Huh, Soonmin Lim, Hyo Geun Kim, Sang Keun Ha, Ho-Young Park, Youngbuhm Huh, Myung Sook Oh
Ginger, which has been widely used for dietary condiment, has been reported to improve memory dysfunction in an animal model of Alzheimer's disease (AD). Recently, a few trials have been carried out to enhance the effects of ginger by improving the bioavailability of its relevant components via fermentation. Some reports have suggested that the fermented ginger has the ability to affect the AD in vitro systems; however, its anti-amnesic effects on an in vivo model still remain to be investigated. In the present study, we aimed to investigate the neuroprotective effects of ginger fermented with Schizosaccharomyces pombe (FG) in the in vivo models of AD...
November 24, 2017: Food & Function
https://www.readbyqxmd.com/read/29167913/synergistic-enhancing-memory-effect-of-donepezil-and-s-47445-an-ampa-positive-allosteric-modulator-in-middle-aged-and-aged-mice
#13
S Bretin, A Krazem, N Henkous, C Froger-Colleaux, E Mocaer, C Louis, N Perdaems, A Marighetto, D Beracochea
Positive allosteric modulators of AMPA receptors (AMPA-PAMs) are described to facilitate cognitive processes in different memory-based models. Among them, S 47445 is a novel potent and selective AMPA-PAM. In order to assess its efficacy after repeated administration, S 47445 effect was evaluated in two aging-induced memory dysfunction tasks in old mice, one short-term working memory model evaluated in a radial maze task and one assessing contextual memory performance. S 47445 was shown to improve cognition in both models sensitive to aging...
November 22, 2017: Psychopharmacology
https://www.readbyqxmd.com/read/29165354/the-role-of-glucagon-like-peptide-1-glp1-in-type-3-diabetes-glp-1-controls-insulin-resistance-neuroinflammation-and-neurogenesis-in-the-brain
#14
REVIEW
Choon Sang Bae, Juhyun Song
Alzheimer's disease (AD), characterized by the aggregation of amyloid-β (Aβ) protein and neuroinflammation, is the most common neurodegenerative disease globally. Previous studies have reported that some AD patients show impaired glucose utilization in brain, leading to cognitive decline. Recently, diabetes-induced dementia has been called "type 3 diabetes", based on features in common with those of type 2 diabetes and the progression of AD. Impaired glucose uptake and insulin resistance in the brain are important issues in type 3 diabetes, because these problems ultimately aggravate memory dysfunction in the brain...
November 22, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29104731/edible-bird-s-nest-prevents-menopause-related-memory-and-cognitive-decline-in-rats-via-increased-hippocampal-sirtuin-1-expression
#15
Zhiping Hou, Peiyuan He, Mustapha Umar Imam, Jiemen Qi, Shiying Tang, Chengjun Song, Maznah Ismail
Menopause causes cognitive and memory dysfunction due to impaired neuronal plasticity in the hippocampus. Sirtuin-1 (SIRT1) downregulation in the hippocampus is implicated in the underlying molecular mechanism. Edible bird's nest (EBN) is traditionally used to improve general wellbeing, and in this study, we evaluated its effects on SIRT1 expression in the hippocampus and implications on ovariectomy-induced memory and cognitive decline in rats. Ovariectomized female Sprague-Dawley rats were fed with normal pellet alone or normal pellet + EBN (6, 3, or 1...
2017: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/29091891/hispidulin-prevents-sevoflurane-induced-memory-dysfunction-in-aged-rats
#16
Lubin Huang, Kejing Huang, Hong Ning
AIM: As a widely used general anesthetic, sevoflurane has been found to induce cognitive and memory defectsin the elderly. This may increase the risk of Alzheimer's disease. This study explores the neuroprotective effect of hispidulin, a natural flavone compound, against sevoflurane-induced memory dysfunction. METHODS: The effect of sevoflurane exposure on memory function was evaluated by novel object recognition and Y-maze testing using an aged rat model. The apoptotic cell death in the hippocampus of rats was assessed using a TUNEL assay...
October 27, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29090690/tip-enhanced-raman-spectroscopy-of-amyloid-%C3%AE-at-neuronal-spines
#17
Mohammadali Tabatabaei, Fabiana A Caetano, Farshid Pashee, Stephen S G Ferguson, François Lagugné-Labarthet
The early stages of Alzheimer's disease pathogenesis are thought to occur at the synapse level, since synapse loss can be directly correlated with memory dysfunction. Considerable evidence has suggested that amyloid beta (Aβ), a secreted proteolytic derivative of amyloid precursor protein, appears to be a critical factor in the early 'synaptic failure' that is observed in Alzheimer's disease pathogenesis. The identification of Aβ at neuronal spines with high spatial resolution and high surface specificity would facilitate unraveling the intricate effect of Aβ on synapse loss and its effect on neighboring neuronal connections...
November 1, 2017: Analyst
https://www.readbyqxmd.com/read/29072169/amnestic-dementia-impairment-in-parkinson-s-disease-the%C3%A2-role-of-body-composition-ageing-and-insulin-resistance
#18
Arthur Oscar Schelp, Cristiane Lara Mendes-Chiloff, Vanessa Cristina Paduan, José Eduardo Corrente, Aline Vieira, Juliana Cristine Nunes Marchette, Juli Thomaz de Souza, Gustavo José Luvizuto, Célia Regina Nogueira, Rodrigo Bazan
BACKGROUND: The risk of cognitive impairment associated with Parkinson's disease (PD) is related to ageing. The role of body compartmentalization and associated metabolic dysfunctions, as a risk factor for dementia in PD is still not clear. OBJECTIVE: To investigate body mass distribution, insulin resistance, and other parameters in patients without dementia, and those with dementia classified as compromised delayed memory. SUBJECTS AND METHODS: We recorded body composition, basal levels of insulin resistance, and other data from 135 patients, who were followed for at least two years...
August 2017: Clinical Nutrition ESPEN
https://www.readbyqxmd.com/read/29064406/diosgenin-rich-yam-extract-enhances-cognitive-function-a-placebo-controlled-randomized-double-blind-crossover-study-of-healthy-adults
#19
Chihiro Tohda, Ximeng Yang, Mie Matsui, Yuna Inada, Emika Kadomoto, Shotaro Nakada, Hidetoshi Watari, Naotoshi Shibahara
Diosgenin, a yam-derived compound, was found to facilitate the repair of axonal atrophy and synaptic degeneration and improve memory dysfunction in a transgenic mouse model of Alzheimer's disease (AD). It was also found to enhance neuronal excitation and memory function even in normal mice. We hypothesized that diosgenin, either isolated or in an extract, may represent a new category of cognitive enhancers with essential activities that morphologically and functionally reinforce neuronal networks. This study aimed to investigate the effects of a diosgenin-rich yam extract on cognitive enhancement in healthy volunteers...
October 24, 2017: Nutrients
https://www.readbyqxmd.com/read/28984584/perception-and-reality-of-cognitive-function-information-processing-speed-perceived-memory-function-and-perceived-task-difficulty-in-older-adults
#20
Anna Torrens-Burton, Nasreen Basoudan, Antony J Bayer, Andrea Tales
This study examines the relationships between two measures of information processing speed associated with executive function (Trail Making Test and a computer-based visual search test), the perceived difficulty of the tasks, and perceived memory function (measured by the Memory Functioning Questionnaire) in older adults (aged 50+ y) with normal general health, cognition (Montreal Cognitive Assessment score of 26+), and mood. The participants were recruited from the community rather than through clinical services, and none had ever sought or received help from a health professional for a memory complaint or mental health problem...
2017: Journal of Alzheimer's Disease: JAD
keyword
keyword
62496
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"