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https://www.readbyqxmd.com/read/29217959/periodontal-therapy-with-0-25-lemongrass-oil-mouthwash-in-reducing-risk-of-cardiovascular-diseases-a-3-arm-prospective-parallel-experimental-study
#1
Dany S Subha, Tangde Pradeep
Background: Periodontal disease is associated with cardiovascular diseases because of its role in host immune-inflammatory response. Serum lipids are the commonest risk factors between periodontal disease and cardiovascular diseases. Materials and Method: A double blinded randomised clinical trial was carried out among 45 subjects with generalised severe periodontitis. They were divided into 3-groups of 15 subjects each. Group A: 0.25% lemongrass oil mouthwash, Group B: 0...
September 2017: Ethiopian Journal of Health Sciences
https://www.readbyqxmd.com/read/29203043/-blood-pressure-target-in-2017
#2
A Yannoutsos, A Bura-Rivière, P Priollet, J Blacher
OBJECTIVE: The issue of how far blood pressure (BP) should be lowered under antihypertensive treatment is still an important matter of scientific debate. The aim of the present review is to consider the clinical relevance of individualized BP goal under treatment in hypertensive patients according to their age, comorbidities or established cardio-vascular (CV) disease. DATA FROM THE LITERATURE: The French and European recommendations propose a systolic BP target between 130 and 139mmHg (<150mmHg after 80 years) and diastolic BP target <90mmHg in hypertensive patients whatever their level of risk...
December 2017: Journal de Médecine Vasculaire
https://www.readbyqxmd.com/read/29201269/cardiac-nonmyocyte-cell-functions-and-crosstalks-in-response-to-cardiotoxic-drugs
#3
REVIEW
Jessica Gambardella, Bruno Trimarco, Guido Iaccarino, Daniela Sorriento
The discovery of the molecular mechanisms involved in the cardiac responses to anticancer drugs represents the current goal of cardio-oncology research. The oxidative stress has a pivotal role in cardiotoxic responses, affecting the function of all types of cardiac cells, and their functional crosstalks. Generally, cardiomyocytes are the main target of research studies on cardiotoxicity, but recently the contribution of the other nonmyocyte cardiac cells is becoming of growing interest. This review deals with the role of oxidative stress, induced by anticancer drugs, in cardiac nonmyocyte cells (fibroblasts, vascular cells, and immune cells)...
2017: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/29201112/association-of-warfarin-therapy-with-apoe-and-vkorc1-genes-polymorphism-in-iranian-population
#4
Sajad Rafiee, Masoumeh Rajabibazl, Reza Meshkani, Azam Daraei, Mehryar Zargari, Fahimeh Sharafeddin, Zahra Fazeli, Attabak Toffani Milani, Maryam Taherkhani
Warfarin is a vitamin K antagonist that genetic and non-genetic factors affected on its dose requirement in the patients with cardio vascular disease. The aim of this study was whether the APOE and VKORC1 polymorphisms influence on warfarin dose requirements in the part of Iranian patients. Blood samples were collected from 86 warfarin-treated patients. After extraction of genomic DNA, the VKORC1 (rs9923231) and the APOE (rs429358 and rs7412) polymorphisms were genotyped by PCR-RFLP technique. We found that the Iranian patients carrying genotypes GA or AA of VKORC1 polymorphism tended to receive lower dose of warfarin (p = 0...
2017: Iranian Journal of Pharmaceutical Research: IJPR
https://www.readbyqxmd.com/read/29197746/proton-therapy-for-locally-advanced-breast-cancer-a-systematic-review-of-the-literature
#5
REVIEW
Emmanuel Kammerer, Jennifer Le Guevelou, Abdulhamid Chaikh, Serge Danhier, Julien Geffrelot, Christelle Levy, Eric Saloux, Jean-Louis Habrand, Juliette Thariat
BACKGROUND: Radiation therapy plays a major role in the management of adjuvant breast cancer with nodal involvement, with an iatrogenic increase of cardio-vascular risk. Photon therapy, even with intensity modulation, has the downsides of high mean heart dose and heterogeneous target coverage, particularly in the case of internal mammary irradiation. This systematic review of the literature aims to evaluate proton therapy in locally advanced breast cancer. MATERIAL AND METHODS: PubMed was searched for original full-text articles with the following search terms: «Proton Therapy» and «Breast Cancer»...
November 24, 2017: Cancer Treatment Reviews
https://www.readbyqxmd.com/read/29190205/hypertension-regulating-angiotensin-peptides-in-the-pathobiology-of-cardiovascular-disease
#6
Misbah Hussain, Fazli Rabbi Awan
Renin angiotensin system (RAS) is an endogenous hormone system involved in the control of blood pressure and fluid volume. Dysregulation of RAS has a pathological role in causing cardiovascular diseases through hypertension. Among several key components of RAS, angiotensin peptides, varying in amino acid length and biological function, have important roles in preventing or promoting hypertension, cardiovascular diseases, stroke, vascular remodeling etc. These peptides are generated by the metabolism of inactive angiotensinogen or its derived peptides by hydrolyzing action of certain enzymes...
November 30, 2017: Clinical and Experimental Hypertension: CHE
https://www.readbyqxmd.com/read/29170061/the-association-between-muscle-mass-deficits-and-arterial-stiffness-in-middle-aged-men
#7
I J Im, H J Choi, S M Jeong, H J Kim, J S Son, H J Oh
BACKGROUND AND AIMS: Early diagnosis of arteriosclerosis is fundamental for the prevention of cardiovascular morbidity and mortality. The current study was performed to identify major predictors of arteriosclerosis and to assess the association between arterial stiffness as measured by cardio-ankle vascular index (CAVI) and muscle mass deficit (MMD) estimated by bioelectrical impedance analysis (BIA) in middle-aged men. METHODS AND RESULTS: Data were gathered from 3356 middle-aged men who visited a health promotion center...
October 12, 2017: Nutrition, Metabolism, and Cardiovascular Diseases: NMCD
https://www.readbyqxmd.com/read/29142443/oral-health-and-erectile-dysfunction
#8
REVIEW
Vijendra P Singh, Sunil K Nettemu, Sowmya Nettem, Rajesh Hosadurga, Sangeeta U Nayak
Ample evidence strongly supports the fact that periodontal disease is a major risk factor for various systemic diseases namely cardio-vascular disease, diabetes mellitus, etc. Recently, investigators focussed on exploring the link between chronic periodontitis (CP) and erectile dysfunction (ED) by contributing to the endothelial dysfunction. Both the diseases share common risk factors. Various studies conducted in different parts of the world in recent years reported the evidence linking this relationship as well as improvement in ED with periodontal treatment...
July 2017: Journal of Human Reproductive Sciences
https://www.readbyqxmd.com/read/29141542/cocoa-polyphenols-evidence-from-epidemiological-studies
#9
Chisa Matsumoto
BACKGROUND: Accumulating evidence suggests potential preventive effects of chocolate/cocoa on the risk of cardio vascular disease (CVD). However, cocoa products also contain high levels of sugar and fat, which increase CVD risk factors. Even, the identity of the substance in chocolate/cocoa that has a favorable effect on CVD and CVD risk factors remains unclear, growing evidence from experimental studies suggests that cocoa polyphenols might be a major contributor to cardiovascular-protective effects...
November 14, 2017: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/29136726/-chinese-expert-consensus-on-the-diagnosis-and-treatment-of-hypertension-in-the-elderly-2017
#10
(no author information available yet)
China has stepped into an aging society. Hypertension is an independent risk factor of cardio-cerebrovascular diseases and related to mortality and disability of the elderly. Compared to middle-aged and young patients with similar blood pressure elevation, the risks of cardiovascular and cerebrovascular events significantly increase in the elderly. Since the Chinese expert consensus on the diagnosis and treatment of hypertension in the elderly(2008, 2011 version) were published, many guidelines have been accordingly updated, which further improved the prevention and control strategy of hypertension...
November 1, 2017: Zhonghua Nei Ke za Zhi [Chinese Journal of Internal Medicine]
https://www.readbyqxmd.com/read/29131062/cardio-renal-determinants-of-erectile-dysfunction-in-primary-prevention-a-cross-sectional-study
#11
Vilma Dzenkeviciute, Zaneta Petrulioniene, Egidija Rinkuniene, Virginijus Sapoka, Marija Petrylaite, Jolita Badariene
OBJECTIVE: To investigate the association between severity of erectile dysfunction, cardiovascular risk and target organ (heart, renal, vascular) damage in men free of cardiovascular diseases (CV). SUBJECTS AND METHODS: This study included 182 men: 100 with erectile dysfunction (ED) (IIEF mean score ≤ 21) and 82 without ED (IIEF mean score > 21). The ED was assessed using the International Index of Erectile Function (IIEF-5). Ultrasound was used to evaluate carotid plaques and left ventricular mass, geometry and diastolic function...
November 5, 2017: Medical Principles and Practice: International Journal of the Kuwait University, Health Science Centre
https://www.readbyqxmd.com/read/29128160/prone-sleeping-position-in-infancy-implications-for-cardiovascular-and-cerebrovascular-function
#12
REVIEW
Kelsee L Shepherd, Stephanie R Yiallourou, Rosemary S C Horne, Flora Y Wong
Advances in neonatal care have improved the survival rates of preterm infants, however, the likelihood of brain injury and neurodevelopmental disability remains a significant problem. Whilst the etiology of preterm brain injury is complex, impairments in the cardio- and cerebro-vascular function have been implicated. During infancy, sleep is vital for brain development. However, instabilities in cardio- and cerebro-vascular function are most marked during sleep. Sleeping position is an important part of a safe sleeping environment...
October 13, 2017: Sleep Medicine Reviews
https://www.readbyqxmd.com/read/29127010/cyclosporine-a-exhibits-gender-specific-nephrotoxicity-in-rats-effect-on-renal-tissue-inflammation
#13
Hany M El-Bassossy, Basma G Eid
Cyclosporine A (CSA) is a widely used immunosuppressant drug known to commonly cause cardio and nephrotoxicity. A study looking at the sex specificity of the cardiotoxicity of CSA revealed that sexual dimorphism existed when looking at the electrocardiographs and left ventricles of CSA-treated rats. We hypothesized that cyclosporine A exhibited gender-specific nephrotoxicity by testing various parameters of kidney function in male and female rats treated for 21 days with 15 mg/kg CSA versus control male and female rats that received a vehicle consisting of 18% kolliphore and 2% ethanol in sterile saline...
November 7, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29110150/the-effect-of-an-aerobic-exercise-bout-24%C3%A2-h-prior-to-each-doxorubicin-treatment-for-breast-cancer-on-markers-of-cardiotoxicity-and-treatment-symptoms-a-rct
#14
Amy A Kirkham, Neil D Eves, Rob E Shave, Kelcey A Bland, Joshua Bovard, Karen A Gelmon, Sean A Virani, Don C McKenzie, Eric J Stöhr, Darren E R Waburton, Kristin L Campbell
PURPOSE: In rodents, a single exercise bout performed 24 h prior to a single doxorubicin treatment provides cardio-protection. This study investigated whether performing this intervention prior to every doxorubicin treatment for breast cancer reduced subclinical cardiotoxicity and treatment symptoms. METHODS: Twenty-four women with early stage breast cancer were randomly assigned to perform a 30-min, vigorous-intensity treadmill bout 24 h prior to each of four doxorubicin-containing chemotherapy treatments or to usual care...
November 6, 2017: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/29103322/prehypertension-and-high-serum-uric-acid-increase-risk-of-arterial-stiffness
#15
Piyanuch Thitiwuthikiat, Duangduan Siriwittayawan, Teonchit Nuamchit
Prehypertension and serum uric acid are emerging as independent risk factors for arterial stiffness and may also predict cardiovascular diseases. Previous studies have demonstrated the association between serum uric acid and arterial stiffness in hypertensive adults, but there are limited studies in prehypertensive adults. We compared the serum uric acid (SUA) and cardio-ankle vascular index (CAVI) between normotensive and prehypertensive participants. The association between SUA, prehypertension and CAVI were investigated...
November 6, 2017: Scandinavian Journal of Clinical and Laboratory Investigation
https://www.readbyqxmd.com/read/29103321/improved-assessment-of-arterial-stiffness-using-corrected-cardio-ankle-vascular-index-cavi0-in-overweight-adolescents-with-white-coat-and-essential-hypertension
#16
Michal Mestanik, Alexander Jurko, Bart Spronck, Alberto P Avolio, Mark Butlin, Tomas Jurko, Zuzana Visnovcova, Andrea Mestanikova, Peter Langer, Ingrid Tonhajzerova
Arterial stiffness is a marker of vascular damage. Although adiposity increases cardiovascular risk, the relationship between paediatric overweight and arterial stiffness is unclear. The study aimed to evaluate the simultaneous effect of hypertension and overweight on arterial stiffness using cardio-ankle vascular index (CAVI) and related novel, theoretically blood pressure (BP)-independent, index CAVI0. CAVI and CAVI0 were measured in 140 adolescent boys (16.0 ± 1.9 years) divided into age-matched groups: normal-weight normotensives, overweight normotensives, overweight white-coat hypertensives, and overweight essential hypertensives...
November 6, 2017: Scandinavian Journal of Clinical and Laboratory Investigation
https://www.readbyqxmd.com/read/29100429/association-study-of-igfbp1-and-igfbp3-polymorphisms-with-hypertension-and-cardio-cerebral-vascular-diseases-in-a-chinese-han-population
#17
Zhengmei Fang, Song Yang, Lijun Zhu, Ying Li, Yanchun Chen, Yuelong Jin, Xianghai Zhao, Hailong Zhao, Xiaotian Chen, Yanping Zhao, Chong Shen, Yingshui Yao
Previous studies have showed that insulin-like growth factor (IGF) axis is involved in the development of hypertension. It is unclear whether genetic variants in the IGF-binding proteins (IGFBPs) contribute to the susceptibility to hypertension. Three single-nucleotide polymorphisms (SNPs) in IGFBP1 and four SNPs in IGFBP3 were selected for genotyping in 2,012 hypertension cases and 2,210 healthy controls and 4,128 subjects were followed up for a median of 5.01 years. Multiple logistic regression and Cox regression were performed to evaluate the association of these seven SNPs with hypertension and cardio-cerebral vascular disease (CCVD)...
September 29, 2017: Oncotarget
https://www.readbyqxmd.com/read/29097771/subclinical-pulmonary-dysfunction-contributes-to-high-altitude-pulmonary-edema-susceptibility-in-healthy-non-mountaineers
#18
Rajinder K Gupta, Poonam Soree, Koundinya Desiraju, Anurag Agrawal, Shashi Bala Singh
HAPE susceptible (HAPE-S, had HAPE episode in past) subjects may have subclinical cardio-pulmonary dysfunction. We compared the results of pulmonary function tests in 25 healthy HAPE-S non-mountaineers and 19 matched HAPE resistant (HAPE-R, no HAPE episode in past). Acute normobaric hypoxia (FIo2 0.12) was administered at sea level to confirm hypoxia intolerance in HAPE-S. Unlike HAPE-R, HAPE-S subjects had elevated baseline and post-hypoxia systolic pulmonary arterial pressures (20.9 ± 3 vs 27.3 ± 5 mm Hg during normoxia and 26...
November 2, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29096858/management-of-patients-with-statin-intolerance
#19
Sabine Fischer, Ulrich Julius
In recent years statins have become an established option in lipid-lowering pharmacotherapy despite the fact that statin intolerance is fairly common. When muscle pains and/or an elevation of the creatine kinase appear, the dose must be lowered in patients with slight symptoms or stopped altogether if the symptoms are more severe. When the symptoms are alleviated and creatine kinase is normalized, re-exposition can be considered. If symptoms recur, treatment with another statin should be attempted - in these cases pravastatin or fluvastatin are recommended, although they are less effective in reducing LDL cholesterol...
November 2017: Atherosclerosis. Supplements
https://www.readbyqxmd.com/read/29079281/association-of-classic-cardiovascular-risk-factors-and-lifestyles-with-the-cardio-ankle-vascular-index-in-a-general-mediterranean-population
#20
Marc Elosua-Bayés, Ruth Martí-Lluch, María Del Mar García-Gil, Lourdes Camós, Marc Comas-Cufí, Jordi Blanch, Anna Ponjoan, Lia Alves-Cabratosa, Roberto Elosua, María Grau, Jaume Marrugat, Rafel Ramos
INTRODUCTION AND OBJECTIVES: The cardio-ankle vascular index (CAVI) assesses arterial stiffness. We aimed to describe the distribution of CAVI in a Mediterranean population, to determine the proportion of CAVI ≥ 9 by sex and coronary risk level, and to assess the association of CAVI with classic cardiovascular risk factors and lifestyle patterns. METHODS: This cross-sectional study was based on the population of Girona province. The CAVI was measured using the VaSera VS-1500...
October 25, 2017: Revista Española de Cardiología
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