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https://www.readbyqxmd.com/read/28331159/the-effect-of-nitroglycerin-on-arterial-stiffness-of-the-aorta-and-the-femoral-tibial-arteries
#1
Tomoyuki Yamamoto, Kazuhiro Shimizu, Mao Takahashi, Ichiro Tatsuno, Kohji Shirai
AIM: The effect of nitroglycerin on proper arterial stiffness of the arterial tree has not been fully clarified. The cardio-ankle vascular index (CAVI), which is an application of the stiffness parameter β theory on the arterial tree from the origin of the aorta to the ankle, was developed recently. Furthermore, the stiffness of the aorta (heart-thigh β (htBeta)) and of the femoral-tibial arteries (thigh to ankle β (taBeta)) could be monitored by applying the same theory. The effects of nitroglycerin on CAVI, htBeta, and taBeta were studied comparing the values of healthy people and those of arteriosclerotic patients...
March 22, 2017: Journal of Atherosclerosis and Thrombosis
https://www.readbyqxmd.com/read/28321055/the-relationships-between-the-differences-in-the-central-blood-pressure-and-brachial-blood-pressure-and-other-factors-in-patients-with-essential-hypertension
#2
Masaki Ryuzaki, Satoshi Morimoto, Michita Niiyama, Yasufumi Seki, Naohiro Yoshida, Yoichi Oshima, Yuki Mizuguchi, Daisuke Watanabe, Takashi Ando, Atsuhiro Ichihara
Objective The management of blood pressure (BP) in hypertensive patients is the key to preventing a progression of organ damage. The brachial BP (bBP) has been used as the representative method for measuring the BP. The central BP (cBP), which is, different from the bBP due to the propagation and the reflection of the pulse wave in the arterial system, has recently received attention because it can now be estimated non-invasively. We examined the relationships between the difference in the central systolic BP (csBP) and the brachial systolic BP (bsBP) (Δ) and other factors in hypertensive patients...
2017: Internal Medicine
https://www.readbyqxmd.com/read/28321052/saline-infusion-test-highly-associated-with-the-incidence-of-cardio-and-cerebrovascular-events-in-primary-aldosteronism
#3
Reiko Hayashi, Daisuke Tamada, Masahiko Murata, Kosuke Mukai, Tetsuhiro Kitamura, Michio Otsuki, Iichiro Shimomura
Primary aldosteronism (PA) is caused by excess secretion of aldosterone and is an independent risk factor for cardio-cerebro-vascular (CCV) events. The goal of treatment of PA should include prevention of CCV events. A definitive diagnosis of PA is established by confirmatory tests [saline infusion test (SIT), furosemide upright test (FUT) and captopril challenge test (CCT)]. However, there is no information on whether the hormone levels measured by these confirmatory tests are associated with CCV events. The aim of this retrospective study was to elucidate the relationship between the results of the above confirmatory tests and prevalence of CCV disease in patients with PA...
March 18, 2017: Endocrine Journal
https://www.readbyqxmd.com/read/28320853/cardio-oncology-vascular-endothelial-growth-factor-inhibitors-salt-and-macrophages-a-complicated-interaction
#4
Javid Moslehi, Arvind K Pandey, Nirmanmoh Bhatia
No abstract text is available yet for this article.
March 20, 2017: Hypertension
https://www.readbyqxmd.com/read/28315122/cardio-oncology-the-nuclear-option
#5
REVIEW
Jorge A Alvarez, Raymond R Russell
PURPOSE OF REVIEW: Cardio-oncology focuses increased effort to decrease cancer treatment-related cardiotoxicity while continuing to improve outcomes. We sought to synthesize the latest in nuclear cardiology as it pertains to the assessment of left ventricular function in preventative guidelines and comparison to other modalities, novel molecular markers of pre-clinical cardiotoxicity, and its role in cardiac amyloid diagnosis. RECENT FINDINGS: Planar ERNA (equilibrium radionuclide angiocardiography) provides a reliable and proven means of monitoring and preventing anthracycline cardiotoxicity, and SPECT ERNA using solid-state gamma cameras may provide reproducible assessments of left ventricular function with reduced radiation exposure...
April 2017: Current Cardiology Reports
https://www.readbyqxmd.com/read/28306749/cigarette-smoking-and-cardio-renal-events-in-patients-with-atherosclerotic-renal-artery-stenosis
#6
Christopher A Drummond, Pamela S Brewster, Wencan He, Kaili Ren, Yanmei Xie, Katherine R Tuttle, Steven T Haller, Kenneth Jamerson, Lance D Dworkin, Donald E Cutlip, Timothy P Murphy, Ralph B D'Agostino, William L Henrich, Jiang Tian, Joseph I Shapiro, Christopher J Cooper
Cigarette smoking causes cardiovascular disease and is associated with poor kidney function in individuals with diabetes mellitus and primary kidney diseases. However, the association of smoking on patients with atherosclerotic renal artery stenosis has not been studied. The current study utilized data from the Cardiovascular Outcomes in Renal Atherosclerotic Lesions (CORAL, NCT00081731) clinical trial to evaluate the effects of smoking on the risk of cardio-renal events and kidney function in this population...
2017: PloS One
https://www.readbyqxmd.com/read/28303909/sprint-interval-training-induces-a-sexual-dimorphism-but-does-not-improve-peak-bone-mass-in-young-and-healthy-mice
#7
Kathrin Koenen, Isabell Knepper, Madlen Klodt, Anja Osterberg, Ioannis Stratos, Thomas Mittlmeier, Tina Histing, Michael D Menger, Brigitte Vollmar, Sven Bruhn, Brigitte Müller-Hilke
Elevated peak bone mass in early adulthood reduces the risk for osteoporotic fractures at old age. As sports participation has been correlated with elevated peak bone masses, we aimed to establish a training program that would efficiently stimulate bone accrual in healthy young mice. We combined voluntary treadmill running with sprint interval training modalities that were tailored to the individual performance limits and were of either high or intermediate intensity. Adolescent male and female STR/ort mice underwent 8 weeks of training before the hind legs were analyzed for cortical and trabecular bone parameters and biomechanical strength...
March 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28297809/-the-interpretation-of-the-sleep-apnea-cardio-vascular-endpoint-save-study
#8
R Chen, Y M Luo
No abstract text is available yet for this article.
March 12, 2017: Chinese Journal of Tuberculosis and Respiratory Diseases
https://www.readbyqxmd.com/read/28295428/atheroprotective-effects-and-molecular-targets-of-tanshinones-derived-from-herbal-medicine-danshen
#9
REVIEW
Jian Fang, Peter J Little, Suowen Xu
Medicinal plant-derived bioactive compounds modulate multiple therapeutic targets in cardiovascular diseases (CVDs), rendering herb-derived phytochemicals effective against one of the major CVDs-atherosclerosis. Danshen (Salvia milthiorriza Bunge) is a Chinese medicine that has been used in cardio- and cerebro-vascular therapeutic remedies in Asian countries for many years. Emerging evidence from cellular, animal, and clinical studies suggests that major lipophilic tanshinones from Danshen can treat atherosclerotic CVDs...
February 16, 2017: Medicinal Research Reviews
https://www.readbyqxmd.com/read/28294880/-results-of-monitoring-of-the-plan-of-measures-directed-to-reduction-of-ischemic-heart-disease-in-north-caucasus-republics-analysis-of-dynamics-of-cardio-vascular-mortality
#10
M N Mamedov
Comparative analysis of dynamics of cardiovascular mortality in Russia and foreign countries as well as main directions of development of cardiological service in Russia are presented in this review article. Plan of measures for reduction of mortality from ischemic heart disease (IHD) was created in 2015. This plan comprises 4 blocks of assessment of the following measures: directed at improvement of primary IHD prevention (1), directed at secondary prevention of complications of IHD (2); directed at improvement of efficacy of medical care of patients with IHD (3), and directed at monitoring of some demographic parameters (4)...
May 2016: Kardiologiia
https://www.readbyqxmd.com/read/28284844/investigating-methotrexate-toxicity-within-a-randomized-double-blinded-placebo-controlled-trial-rationale-and-design-of-the-cardiovascular-inflammation-reduction-trial-adverse-events-cirt-ae-study
#11
Jeffrey A Sparks, Medha Barbhaiya, Elizabeth W Karlson, Susan Y Ritter, Soumya Raychaudhuri, Cassandra C Corrigan, Fengxin Lu, Jacob Selhub, Daniel I Chasman, Nina P Paynter, Paul M Ridker, Daniel H Solomon
BACKGROUND: The role of low dose methotrexate (LDM) in potential serious toxicities remains unclear despite its common use. Prior observational studies investigating LDM toxicity compared LDM to other active drugs. Prior placebo-controlled clinical trials of LDM in inflammatory conditions were not large enough to investigate toxicity. The Cardiovascular Inflammation Reduction Trial (CIRT) is an ongoing NIH-funded, randomized, double-blind, placebo-controlled trial of LDM in the secondary prevention of cardiovascular disease...
February 10, 2017: Seminars in Arthritis and Rheumatism
https://www.readbyqxmd.com/read/28275591/clinical-application-of-the-cardio-ankle-vascular-index-in-asymptomatic-healthy-koreans
#12
REVIEW
Su-Yeon Choi
BACKGROUND: Arterial stiffness has been established as a surrogate marker for the prognosis of cardiovascular disease. Arterial stiffness is also a predictor of future cardiovascular events, and is the earliest detectable manifestation of adverse structural and functional changes to blood vessel walls. SUMMARY AND KEY MESSAGES: The cardio-ankle vascular index (CAVI) is an index representing the stiffness of the entire arterial segments from the aorta to the ankle independent of the blood pressure at the time of the measurement...
January 2017: Pulse (Basel, Switzerland)
https://www.readbyqxmd.com/read/28275590/protocol-for-evaluating-the-cardio-ankle-vascular-index-to-predict-cardiovascular-events-in-japan-a-prospective-multicenter-cohort-study
#13
REVIEW
Toru Miyoshi, Hiroshi Ito, Shigeo Horinaka, Kohji Shirai, Jitsuo Higaki, Hajime Orimio
INTRODUCTION: The cardio-ankle vascular index (CAVI) was developed in Japan and is a blood pressure-independent index of arterial stiffness from the origin of the aorta to the ankle. In recent years, it has been studied by many researchers worldwide, and it is strongly anticipated that it will play a role as a predictive factor for arteriosclerotic diseases. The objective of this study was to examine the benefits of using CAVI as a predictor of cardiovascular events in high-risk patients...
January 2017: Pulse (Basel, Switzerland)
https://www.readbyqxmd.com/read/28275589/cardio-ankle-vascular-index-in-a-thai-population
#14
REVIEW
Teerapat Yingchoncharoen, Piyamitr Sritara
Arterial stiffness as measured by the cardio-ankle vascular index (CAVI) is a widely available method in Thailand. Data from a large cross-sectional study revealed a significant correlation of CAVI and the presence of coronary artery disease as detected from 64-slice coronary computed tomography arteriography. Futhermore, CAVI was shown to predict long-term cardiovascular events in the patients with intermediate cardiovascular risk.
January 2017: Pulse (Basel, Switzerland)
https://www.readbyqxmd.com/read/28274093/canonical-transient-receptor-potential-channels-and-their-link-with-cardio-cerebro-vascular-diseases
#15
REVIEW
Xiong Xiao, Hui-Xia Liu, Kuo Shen, Wei Cao, Xiao-Qiang Li
The canonical transient receptor potential channels (TRPCs) constitute a series of nonselective cation channels with variable degrees of Ca²⁺ selectivity. TRPCs consist of seven mammalian members, TRPC1, TRPC2, TRPC3, TRPC4, TRPC5, TRPC6, and TRPC7, which are further divided into four subtypes, TRPC1, TRPC2, TRPC4/5, and TRPC3/6/7. These channels take charge of various essential cell functions such as contraction, relaxation, proliferation, and dysfunction. This review, organized into seven main sections, will provide an overview of current knowledge about the underlying pathogenesis of TRPCs in cardio/cerebrovascular diseases, including hypertension, pulmonary arterial hypertension, cardiac hypertrophy, atherosclerosis, arrhythmia, and cerebrovascular ischemia reperfusion injury...
March 10, 2017: Biomolecules & Therapeutics
https://www.readbyqxmd.com/read/28272814/the-relationship-between-cardio-ankle-vascular-index-and-subclinical-atherosclerosis-evaluated-by-cardiac-computed-tomographic-angiography
#16
Suguru Matsumoto, Rine Nakanishi, Yanting Luo, Michael Kim, Anas Alani, Negin Nezarat, Christopher Dailing, Matthew J Budoff
BACKGROUND: The cardio-ankle vascular index (CAVI) is a new noninvasive index to evaluate arterial stiffness. We investigated whether CAVI can predict severity, extent, and burden of coronary artery disease by comparing results with cardiac computed tomographic angiography (CCTA). HYPOTHESIS: CAVI may predict the presence of subclinical atherosclerosis. METHODS: We prospectively enrolled 95 patients (66% male; mean age, 50 ± 16 years) who underwent both CCTA and CAVI consecutively...
March 8, 2017: Clinical Cardiology
https://www.readbyqxmd.com/read/28272233/age-and-cigarette-smoking-modulate-the-relationship-between-pulmonary-function-and-arterial-stiffness-in-heart-failure-patients
#17
Li Li, Bangchuan Hu, Shijin Gong, Yihua Yu, Jing Yan
The aim of this study was to assess the relationship between arterial stiffness and pulmonary function in chronic heart failure (CHF).Outpatients previously diagnosed as CHF were enrolled between April 2008 and March 2010, and submitted to arterial stiffness measurement and lung function assessment. Spirometry was performed by measuring forced vital capacity (FVC), the fraction of predicted FVC, forced expiratory volume in 1 second (FEV1), the percentage of predicted FEV1 in 1 second, FEV1 to FVC ratio, and the percentage of predicted FEV1/FVC...
March 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28256325/cardio-vascular-reserve-index-cvri-during-exercise-complies-with-the-pattern-assumed-by-the-cardiovascular-reserve-hypothesis
#18
Michael J Segel, Ben-Zion Bobrovsky, Itay E Gabbay, Issahar Ben-Dov, Ronen Reuveny, Uri Gabbay
OBJECTIVES: The Cardio-vascular reserve index (CVRI) had been empirically validated in diverse morbidities as a quantitative estimate of the reserve assumed by the cardiovascular reserve hypothesis. This work evaluates whether CVRI during exercise complies with the cardiovascular reserve hypothesis. DESIGN: Retrospective study based on a database of patients who underwent cardio-pulmonary exercise testing (CPX) for diverse indications. METHODS: Patient's physiological measurements were retrieved at four predefined CPX stages (rest, anaerobic threshold, peak exercise and after 2min of recovery)...
May 1, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28195197/let-7e-modulates-the-inflammatory-response-in-vascular-endothelial-cells-through-cerna-crosstalk
#19
Zongwei Lin, Junfeng Ge, Zhe Wang, Jianwei Ren, Xiaowei Wang, Hui Xiong, Jing Gao, Yan Zhang, Qunye Zhang
The inflammatory responses of vascular endothelial cells (VECs) are critical in the development of many cardio-cerebrovascular diseases. Let-7e is an important regulator of endothelial function and inflammation. However, the effects and mechanisms of let-7e on VECs inflammation have not been studied until recently. Thus, we investigated these issues and found that in addition to proliferation, apoptosis and cell adhesion, let-7e was also implicated in the regulation of inflammatory responses through a complex network, including IκBβ and lncRNA lnc-MKI67IP-3...
February 14, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28194484/perturbations-of-the-anti-ageing-hormone-klotho-in-patients-with-type-1-diabetes-and-microalbuminuria
#20
Giuseppe Maltese, Nikolaos Fountoulakis, Richard C Siow, Luigi Gnudi, Janaka Karalliedde
AIMS/HYPOTHESIS: Patients with type 1 diabetes and microalbuminuria are at high risk of cardiovascular disease (CVD) and end-stage renal disease. Soluble Klotho is an anti-ageing circulating hormone involved in phosphate metabolism and vascular homeostasis through protective effects on the endothelium and antioxidant actions. The role of soluble Klotho in patients with type 1 diabetes and microalbuminuria is unknown. METHODS: In a cross-sectional single-centre study we evaluated the levels of circulating serum soluble Klotho in 33 participants with type 1 diabetes and a history of microalbuminuria (receiving renin-angiotensin system [RAS] inhibitors) and 45 participants with type 1 diabetes without a history of microalbuminuria (not receiving RAS or other antihypertensive drugs)...
February 13, 2017: Diabetologia
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