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https://www.readbyqxmd.com/read/29672186/atherosclerosis-of-the-carotid-bulb-is-associated-with-the-severity-of-orthostatic-hypotension-in-non-diabetic-adult-patients-a-cross-sectional-study
#1
Yusuke Kobayashi, Hiroaki Ishiguro, Tetsuya Fujikawa, Hideo Kobayashi, Koichiro Sumida, Minako Kagimoto, Yuki Okuyama, Yosuke Ehara, Mari Katsumata, Megumi Fujita, Akira Fujiwara, Sanae Saka, Keisuke Yatsu, Nobuhito Hirawa, Yoshiyuki Toya, Gen Yasuda, Satoshi Umemura, Kouichi Tamura
BACKGROUND: The carotid bulb has a high density of baroreceptors that play an important role in maintaining blood pressure. We hypothesized that atherosclerosis of the carotid bulb would reflect the severity of orthostatic hypotension more accurately than would atherosclerosis of other carotid artery segments. METHODS: This cross-sectional study included 198 non-diabetic adults. We measured the cardio-vascular ankle index as an index of arterial stiffness, intima-media thickness in each carotid artery segment (internal carotid artery, carotid bulb, distal and proximal portions, respectively, of the common carotid artery) as a measure of atherosclerosis, and heart rate variability as a measure of cardiac autonomic function...
April 19, 2018: Clinical and Experimental Hypertension: CHE
https://www.readbyqxmd.com/read/29669944/neutrophil-subsets-and-their-gene-signature-associate-with-vascular-inflammation-and-coronary-atherosclerosis-in-lupus
#2
Philip M Carlucci, Monica M Purmalek, Amit K Dey, Yenealem Temesgen-Oyelakin, Simantini Sakhardande, Aditya A Joshi, Joseph B Lerman, Alice Fike, Michael Davis, Jonathan H Chung, Martin P Playford, Mohammad Naqi, Pragnesh Mistry, Gustavo Gutierrez-Cruz, Stefania Dell'Orso, Faiza Naz, Taufiq Salahuddin, Balaji Natarajan, Zerai Manna, Wanxia L Tsai, Sarthak Gupta, Peter Grayson, Heather Teague, Marcus Y Chen, Hong-Wei Sun, Sarfaraz Hasni, Nehal N Mehta, Mariana J Kaplan
BACKGROUND: Systemic lupus erythematosus (SLE) is associated with enhanced risk of atherosclerotic cardiovascular disease not explained by Framingham risk score (FRS). Immune dysregulation associated to a distinct subset of lupus proinflammatory neutrophils (low density granulocytes; LDGs) may play key roles in conferring enhanced CV risk. This study assessed if lupus LDGs are associated with in vivo vascular dysfunction and inflammation and coronary plaque. METHODS: SLE subjects and healthy controls underwent multimodal phenotyping of vascular disease by quantifying vascular inflammation (18F-fluorodeoxyglucose-PET/CT [18F-FDG-PET/CT]), arterial dysfunction (EndoPAT and cardio-ankle vascular index), and coronary plaque burden (coronary CT angiography)...
April 19, 2018: JCI Insight
https://www.readbyqxmd.com/read/29662315/pitfalls-in-the-ankle-brachial-index-and-brachial-ankle-pulse-wave-velocity
#3
Dai Ato
Background: The ankle-brachial index (ABI) and pulse wave velocity (PWV) are indices of atherosclerosis and arterial stiffness. The Japan-made measuring devices of those indices have spread widely because of their convenience and the significance of the parameters. However, studies that comprehensively discuss the various pitfalls in using these indices are not available. Methods: This study presents several representative pitfalls in using the ABI and brachial-ankle PWV (baPWV) by showing the result sheets of the device, "the Vascular Profiler"...
2018: Vascular Health and Risk Management
https://www.readbyqxmd.com/read/29661162/the-cold-pressor-test-in-interictal-migraine-patients-different-parasympathetic-pupillary-response-indicates-dysbalance-of-the-cranial-autonomic-nervous-system
#4
Ozan E Eren, Ruth Ruscheweyh, Christoph Schankin, Florian Schöberl, Andreas Straube
BACKGROUND: Data on autonomic nervous system (ANS) activations in migraine patients are quite controversial, with previous studies reporting over- and underactivation of the sympathetic as well as parasympathetic nervous system. In the present study, we explicitly aimed to assess the cranial ANS in migraine patients compared to healthy controls by applying the cold pressor test to a cohort of migraine patients in the interictal phase and measuring the pupillary response. METHODS: In this prospective observational study, a strong sympathetic stimulus was applied to 20 patients with episodic migraine in the interictal phase and 20 matched controls without migraine, whereby each participant dipped the left hand into ice-cold (4 °C) water for a maximum of 5 min (cold pressor test)...
April 16, 2018: BMC Neurology
https://www.readbyqxmd.com/read/29659479/oral-dysbiotic-communities-and-their-implications-in-systemic-diseases
#5
REVIEW
Preethi Sudhakara, Abishek Gupta, Anshumouli Bhardwaj, Aruni Wilson
The human body supports the growth of a wide array of microbial communities in various niches such as the oral cavity, gastro-intestinal and urogenital tracts, and on the surface of the skin. These host associated microbial communities include yet-un-cultivable bacteria and are influenced by various factors. Together, these communities of bacteria are referred to as the human microbiome. Human oral microbiome consists of both symbionts and pathobionts. Deviation from symbiosis among the bacterial community leads to “dysbiosis”, a state of community disturbance...
April 16, 2018: Dentistry journal
https://www.readbyqxmd.com/read/29655953/risk-factors-predisposing-to-acute-coronary-syndromes-in-young-women-%C3%A2-45-years-of-age
#6
Maciej Bęćkowski, Marek Gierlotka, Mariusz Gąsior, Lech Poloński, Tomasz Zdrojewski, Rafał Dąbrowski, Jarosław Karwowski, Ilona Kowalik, Wojciech Drygas, Hanna Szwed
BACKGROUND: Acute coronary syndromes (ACS) are rare in young women. The purpose of this study was to characterize risk factors (RF) predisposing to ACS in young women and evaluate possible age-related differences. METHODS AND RESULTS: We studied 1941 young women with ACS aged ≤45 years (≤45ACS) from the PL-ACS registry and compared them with two control groups: 4275 women aged 63-64 years with ACS (63-64ACS) from the PL-ACS registry and 1170 young healthy women aged ≤45 years (≤45H) without confirmed coronary artery disease (CAD), from two national, representative, cross-sectional population health surveys, NATPOL 2011 and WOBASZ...
April 4, 2018: International Journal of Cardiology
https://www.readbyqxmd.com/read/29653065/tet2-a-novel-epigenetic-regulator-and-potential-intervention-target-for-atherosclerosis
#7
Yami Liu, Wen Peng, Kai Qu, Xiaolong Lin, Zhaolin Zeng, Jiaojiao Chen, Dangheng Wei, Zuo Wang
Atherosclerosis is the underlying cause of cardio-cerebrovascular disease. However, the mechanisms of atherosclerosis are still unclear. The modification of DNA methylation has an important role in atherosclerosis development. As a member of the Ten-eleven translocation (TET) family, TET methylcytosine dioxygenase 2 (TET2) can modify DNA methylation by catalyzing 5-methylcytosine to 5-hydroxymethylcytosine and mediate DNA demethylation. Recent findings suggest that TET2 is related to the phenotype transformation of vascular smooth muscle cells, endothelial dysfunction, and inflammation of macrophage, the key factors of atherosclerosis...
April 13, 2018: DNA and Cell Biology
https://www.readbyqxmd.com/read/29652826/cardiovascular-mechanisms-of-action-of-anthocyanins-may-be-associated-with-the-impact-of-microbial-metabolites-on-heme-oxygenase-1-in-vascular-smooth-muscle-cells
#8
Emily F Warner, Ildefonso Rodriguez-Ramiro, Maria A O'Connell, Colin D Kay
Anthocyanins are reported to have cardio-protective effects, although their mechanisms of action remain elusive. We aimed to explore the effects of microbial metabolites common to anthocyanins and other flavonoids on vascular smooth muscle heme oxygenase-1 (HO-1) expression. Thirteen phenolic metabolites identified by previous anthocyanin human feeding studies, as well as 28 unique mixtures of metabolites and their known precursor structures were explored for their activity on HO-1 protein expression in rat aortic smooth muscle cells (RASMCs)...
April 13, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29649983/ncx-db-a-unified-resource-for-integrative-analysis-of-the-sodium-calcium-exchanger-super-family
#9
Katrin Bode, Damien M O'Halloran
Na+ /Ca2+ exchangers are low-affinity high-capacity transporters that mediate Ca2+ extrusion by coupling Ca2+ efflux to the influx of Na+ ions. The Na+ /Ca2+ exchangers form a super-family comprised of three branches each differing in ion-substrate selectivity: Na+ /Ca2+ exchangers (NCX), Na+ /Ca2+ /K+ exchangers, and Ca2+ /cation exchangers. Their primary function is to maintain Ca2+ homeostasis and play a particularly important role in excitable cells that experience transient Ca2+ fluxes. Research into the role and activity of Na+ /Ca2+ exchangers has focused extensively on the cardio-vascular system, however, growing evidence suggests that Na+ /Ca2+ exchangers play a key role in neuronal processes such as memory formation, learning, oligodendrocyte differentiation, neuroprotection during brain ischemia and axon guidance...
April 13, 2018: BMC Neuroscience
https://www.readbyqxmd.com/read/29644228/how-are-countries-dealing-with-their-current-cardio-vascular-disease-burden-a-snapshot-from-the-who-eastern-mediterranean-region-emr
#10
EDITORIAL
Asmus Hammerich
In recent years, a number of global commitments have been made in the area of noncommunicable diseases (NCD). These include the UN NCD Political Declaration in 2011, and the UN Comprehensive Review on NCDs and Outcome Document in 2014. Nine global targets have been agreed in the area of NCDs, and NCDs have been addressed in the Sustainable Development Goals (SDG). Another UN high-level meeting will take place in September 2018 to assess country progress across the globe. At the regional level, a number of initiates have taken place to deliver on these global commitments...
March 14, 2018: Global Cardiology Science & Practice
https://www.readbyqxmd.com/read/29642917/gender-specific-association-of-serum-uric-acid-levels-and-cardio-ankle-vascular-index-in-chinese-adults
#11
Xiaoya Zheng, Qiang Wei, Jian Long, Lilin Gong, Hua Chen, Rong Luo, Wei Ren, Yonghong Wang
BACKGROUND: Little is known about the relationship between serum uric acid (SUA) and cardio-ankle vascular index (CAVI) in Chinese population. Therefore, we aimed to investigate the gender difference in the association of SUA and CAVI in a southwestern Chinese population. METHODS: Data were obtained from subjects via routine physical examinations in the Public Health Center of our hospital between 2011 and 2014 in Chongqing. The data included completed anthropometry and blood biochemical indicators...
April 11, 2018: Lipids in Health and Disease
https://www.readbyqxmd.com/read/29629375/arterial-stiffness-is-associated-with-peripheral-sensory-neuropathy-in-diabetes-patients-in-ghana
#12
Kwame Yeboah, Jennifer A Agyekum, Richard N A Owusu Mensah, Patrick K Affrim, Linda Adu-Gyamfi, Rita O Doughan, Afua B Adjei
Objective: Peripheral sensory neuropathy (PSN) is among microvascular complications of diabetes that make patients prone to ulceration and amputation. Arterial stiffness is a predictor of cardiovascular diseases and microvascular complications associated with diabetes. We investigated the association between PSN and arterial stiffness, measured as aortic pulse wave velocity (PWVao) and cardio-ankle vascular index (CAVI). Method: In a case-control design, arterial stiffness was measured in 240 diabetes patients and 110 nondiabetic control...
2018: Journal of Diabetes Research
https://www.readbyqxmd.com/read/29626707/longitudinal-association-between-psychosocial-stress-and-retinal-microvasculature-in-children-and-adolescents
#13
Carola J C Van Aart, Tim S Nawrot, Isabelle Sioen, Patrick De Boever, Mahmoud Zaqout, Stefaan De Henauw, Nathalie Michels
BACKGROUND: Retinal microvessels provides a window to assess the microcirculation of heart and brain, and might reflect cardio- or cerebrovascular disease risk. Limited information exist on the relation between psychosocial stress and the microcirculation, even though psychosocial stress might trigger vascular diseases. This study investigates whether childhood psychosocial stress is a predictor of retinal microvasculature. METHODS: We followed-up 182 Belgian children, aged 5...
March 30, 2018: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/29618841/greater-reductions-in-plasma-aldosterone-with-aliskiren-in-hypertensive-patients-with-higher-soluble-pro-renin-receptor-level
#14
Kanako Bokuda, Satoshi Morimoto, Yasufumi Seki, Midori Yatabe, Daisuke Watanabe, Junichi Yatabe, Takashi Ando, Satoru Shimizu, Hiroshi Itoh, Atsuhiro Ichihara
The (pro)renin receptor is important in the regulation of the tissue renin-angiotensin-aldosterone system. The benefits and safety of single-aliskiren treatment without other renin-angiotensin-aldosterone system inhibitors remain unclear. The serum level of the soluble form of the (pro)renin receptor is thought to be a biomarker reflecting the activity of the tissue renin-angiotensin-aldosterone system. We investigated the effects of single renin-angiotensin-aldosterone system blockade with aliskiren on renal and vascular functions and determined if serum level of the soluble (pro)renin receptor was a predictor of aliskiren efficacy in hypertensive patients with chronic kidney disease...
April 4, 2018: Hypertension Research: Official Journal of the Japanese Society of Hypertension
https://www.readbyqxmd.com/read/29615543/intermittent-hypoxia-induces-beneficial-cardiovascular-remodeling-in-left-ventricular-function-of-type-1-diabetic-rat
#15
Fırat Akat, Hakan Fıçıcılar, Ayşegül Durak, Erkan Tuncay, Ali Doğan Dursun, Ferda Topal Çelikkan, Bizden Sabuncuoğlu, Belma Turan, Metin Baştuğ
OBJECTIVE: Depressed mechanical activity is a marked complication in diabetics. Hypoxia has properties for novel diagnostic and therapeutic strategies, while intermittent hypoxia (IH) provides early functional and histologic remodeling, including some cardio benefits in early hemodynamic alterations with histologic remodeling and delayed changes in peripheral vasoreactivity. Therefore, we aimed to examine whether IH application presents a cardioprotective effect, via stabilization of hypoxia-inducible factor (HIF) in streptozotocin (STZ)-induced diabetic rat heart...
April 2018: Anatolian Journal of Cardiology
https://www.readbyqxmd.com/read/29615540/can-serum-cystatin-c-predict-long-term-survival-in-cardiac-surgery-patients
#16
Valentina Rovella, Giulia Marrone, Mariarita Dessì, Michele Ferrannini, Nicola Toschi, Antonio Pellegrino, Maurizio Casasco, Nicola Di Daniele, Annalisa Noce
Renal dysfunction is a risk factor for morbidity and mortality in cardiac surgery patients. Serum Cystatin C (sCysC) is a well-recognized marker of early renal dysfunction but few reports evaluate its prognostic cardio-vascular role. The aim of the study is to consider the prognostic value of sCysC for cardiovascular mortality. Four hundred twenty-four cardiac-surgery patients (264 men and 160 women) were enrolled. At admission, all patients were tested for renal function and inflammatory status. Patients were subdivided in subgroups according to the values of the following variables: sCysC, serum Creatinine (sCrea), age, high sensitivity-C Reactive Protein, fibrinogen, surgical procedures and Kaplan-Meier cumulative survival curves were plotted...
March 27, 2018: Aging
https://www.readbyqxmd.com/read/29605673/high-fat-diet-exacerbates-early-psoriatic-skin-inflammation-independent-of-obesity-saturated-fatty-acids-as-key-players
#17
Diana Herbert, Sandra Franz, Yulia Popkova, Ulf Anderegg, Jürgen Schiller, Katharina Schwede, Axel Lorz, Jan C Simon, Anja Saalbach
In obesity, hypertrophic adipocytes secret high amounts of adipocytokines resulting in low-grade inflammation- amplified by infiltrating pro-inflammatory macrophages, oxidative stress, hypoxia and lipolysis. It is known, that these chronic pro-inflammatory conditions support the development of type II diabetes and cardio vascular diseases, while mechanisms of obesity-related exacerbation of inflammatory skin disorders like psoriasis are unclear. In this study, we uncover nutritional saturated fatty acids (SFAs) as major risk factors for the amplification of skin inflammation, independent of obesity-related parameters, like fat mass extension, adipocytokines and glucose homeostasis...
March 29, 2018: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/29605358/surgical-management-of-children-presenting-with-surgical-needed-tracheal-stenosis
#18
Marie-Eva Rossi, Eric Moreddu, Loïc Macé, Jean-Michel Triglia, Richard Nicollas
OBJECTIVES: The purpose of this work was to assess epidemiological aspects, surgical approach, morbidity and mortality rates of patients presenting with tracheal stenosis requiring surgery, and the evolution of surgical techniques over the last years. METHODS: We performed a retrospective observational study from 1990 to 2017 in a pediatric tertiary-care center with needing surgery for tracheal stenosis. We analyzed clinical patients' characteristics, type of stenosis, type of surgery and follow-up...
May 2018: International Journal of Pediatric Otorhinolaryngology
https://www.readbyqxmd.com/read/29602796/survival-rate-and-predictors-of-mortality-in-patients-hospitalised-with-heart-failure-a-cohort-study-on-the-data-of-persian-registry-of-cardiovascular-disease-prove
#19
Mahshid Givi, Davood Shafie, Fatemeh Nouri, Mohammad Garakyaraghi, Ghasem Yadegarfar, Nizal Sarrafzadegan
OBJECTIVES: Heart failure (HF) has a high rate of hospitalisation and mortality. We examined its risk factors, survival rate and the predictors. METHODS: In this prospective cohort study, demographic, clinical and treatment data of 1223 patients hospitalised with HF were extracted from the Persian Registry Of cardio Vascular diseasE (PROVE)/HF registry. Survival rate and HR and their association with other variables were assessed. RESULTS: 835 (68...
March 30, 2018: Postgraduate Medical Journal
https://www.readbyqxmd.com/read/29601504/label-free-electrochemical-immunoassay-for-c-reactive-protein
#20
Madasamy Thangamuthu, Christian Santschi, Olivier J F Martin
C-reactive protein (CRP) is one of the most expressed proteins in blood during acute phase inflammation, and its minute level increase has also been recognized for the clinical diagnosis of cardio vascular diseases. Unfortunately, the available commercial immunoassays are labour intensive, require large sample volumes, and have practical limitations, such as low stability and high production costs. Hence, we have developed a simple, cost effective, and label-free electrochemical immunoassay for the measurement of CRP in a drop of serum sample using an immunosensor strip made up of a screen printed carbon electrode (SPE) modified with anti-CRP functionalized gold nanoparticles (AuNPs)...
March 30, 2018: Biosensors
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