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Ductal carcinoma in situ

Melissa Alexander, Jessica Beyda, Anupma Nayak, Shabnam Jaffer
CONTEXT: - Mammographic screening has increased the incidence of ductal carcinoma in situ (DCIS), but this has not been accompanied by a decline in the incidence of invasive carcinoma (IC). Consequently, the surgical treatment of DCIS has recently been questioned, with some advocating only surveillance (with or without neoadjuvant endocrine therapy) after a core biopsy diagnosis of DCIS. OBJECTIVES: - To examine the predictive value of a core biopsy diagnosis of DCIS, particularly the upgrade rate to IC, and to identify associated factors...
June 22, 2018: Archives of Pathology & Laboratory Medicine
Somaia M Abdelmegeed, Sulma Mohammed
Animal models for examining human breast cancer (HBC) carcinogenesis have been extensively studied and proposed. With the recent advent of immunotherapy, significant attention has been focused on the dog as a model for human cancer. Dogs develop mammary tumors and other cancer types spontaneously with an intact immune system, which exhibit a number of clinical and molecular similarities to HBC. In addition to the spontaneous tumor presentation, the clinical similarities between human and canine mammary tumors (CMT) include the age at onset, hormonal etiology and course of the diseases...
June 2018: Oncology Letters
Hayley C Oligane, Wendie A Berg, Andriy I Bandos, Sue S Chen, Sahand Sohrabi, Maria Anello, Margarita L Zuley
Purpose To determine rate of malignancy at stereotactic biopsy of amorphous calcifications with different distributions using current imaging, clinical, and histopathologic criteria. Materials and Methods From January 2009 to September 2013, this retrospective study reviewed a large set of stereotactic biopsies to identify amorphous calcifications and their clinical, imaging, and histopathologic characteristics. Calcification distribution was correlated with malignancy rate after adjusting for known risk factors using logistic regression...
June 19, 2018: Radiology
Michelle L Haslinger, Michael Sosin, Alex J Bartholomew, Andrew Crocker, Aiste Gulla, Shawna C Willey, Troy A Pittman, Eleni A Tousimis
BACKGROUND: The aim of this study is to describe a less aggressive approach to management of positive nipple margin following nipple-sparing mastectomy (NSM), allowing for preservation of the nipple-areolar complex (NAC). STUDY DESIGN: A single-institution retrospective chart review was performed for patients undergoing NSM from 1989 to 2017. Positive nipple margin was defined as any residual invasive carcinoma or ductal carcinoma in situ (DCIS) within the additional nipple margin...
June 15, 2018: Annals of Surgical Oncology
Babak Ehteshami Bejnordi, Maeve Mullooly, Ruth M Pfeiffer, Shaoqi Fan, Pamela M Vacek, Donald L Weaver, Sally Herschorn, Louise A Brinton, Bram van Ginneken, Nico Karssemeijer, Andrew H Beck, Gretchen L Gierach, Jeroen A W M van der Laak, Mark E Sherman
The breast stromal microenvironment is a pivotal factor in breast cancer development, growth and metastases. Although pathologists often detect morphologic changes in stroma by light microscopy, visual classification of such changes is subjective and non-quantitative, limiting its diagnostic utility. To gain insights into stromal changes associated with breast cancer, we applied automated machine learning techniques to digital images of 2387 hematoxylin and eosin stained tissue sections of benign and malignant image-guided breast biopsies performed to investigate mammographic abnormalities among 882 patients, ages 40-65 years, that were enrolled in the Breast Radiology Evaluation and Study of Tissues (BREAST) Stamp Project...
June 13, 2018: Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc
Ken Tawara, Celeste Bolin, Jordan Koncinsky, Sujatha Kadaba, Hunter Covert, Caleb Sutherland, Laura Bond, Joseph Kronz, Joel R Garbow, Cheryl L Jorcyk
BACKGROUND: Systemic and chronic inflammatory conditions in patients with breast cancer have been associated with reduced patient survival and increased breast cancer aggressiveness. This paper characterizes the role of an inflammatory cytokine, oncostatin M (OSM), in the preintravasation aspects of breast cancer metastasis. METHODS: OSM expression levels in human breast cancer tissue samples were assessed using tissue microarrays, and expression patterns based on clinical stage were assessed...
June 14, 2018: Breast Cancer Research: BCR
Julia L Savage, Deborah O Jeffries, Mitra Noroozian, Michael S Sabel, Julie M Jorns, Mark A Helvie
OBJECTIVE: Pleomorphic lobular carcinoma in situ (PLCIS) is an aggressive subtype of lobular carcinoma in situ treated similarly to ductal carcinoma in situ. The purpose of this study was to determine the imaging findings, upgrade rate of PLCIS at core needle biopsy (CNB), and the treatment and outcomes of these patients. MATERIALS AND METHODS: This retrospective single-institution study included women with PLCIS at CNB or excisional biopsy without concomitant DCIS or invasive carcinoma between January 1, 1999, and July 20, 2016...
June 12, 2018: AJR. American Journal of Roentgenology
Kui Son Choi, Minjoo Yoon, Seung Hoon Song, Mina Suh, Boyoung Park, Kyu Won Jung, Jae Kwan Jun
In Asian countries, breast densities and the proportion of younger women with breast cancer are higher than those in Western countries. This study was designed to determine differences in stage at diagnosis of breast cancer among Korean women according to screening history. The study population was derived from the Korea National Cancer Screening Program (KNCSP). The study cohort comprised 17,689 women who were newly diagnosed with breast cancer in 2011 and were invited to undergo breast cancer screening via the KNCSP between 2002 and 2011...
June 11, 2018: Scientific Reports
Rüdiger Schulz-Wendtland, Caroline Preuss, Peter A Fasching, Christian R Loehberg, Michael P Lux, Julius Emons, Matthias W Beckmann, Michael Uder, Markus Mueller-Schimpfle
Introduction: For decades, conventional galactography was the only imaging technique capable of showing the mammary ducts. Today, diagnosis is based on a multimodal concept which combines high-resolution ultrasound with magnetic resonance (MR) mammography and ductoscopy/galactoscopy and has a sensitivity and specificity of up to 95%. This study used tomosynthesis in galactography for the first time and compared the synthetic digital 2D full-field mammograms generated with this technique with the images created using the established method of ductal sonography...
May 2018: Geburtshilfe und Frauenheilkunde
Prakasit Chirappapha, Pongsakorn Srichan, Panuwat Lertsithichai, Panya Thaweepworadej, Thongchai Sukarayothin, Monchai Leesombatpaiboon, Youwanush Kongdan
Background: Nipple-sparing mastectomy (NSM) has been proven to be oncologically safe for treating breast cancer. This procedure had been developed to optimize the esthetic outcome and reduce feeling mutilation after mastectomy. Risks of necrotic complications and diminishing nipple-areola complex (NAC) sensation are common complications affecting the patient's satisfaction after the surgery. The evaluation of NAC sensation should be also investigated. Methods: We prospectively analyzed 55 NSMs that were performed on 52 patients for both therapeutic and prophylactic indications in Ramathibodi Hospital from May 2007 to September 2015...
April 2018: Plastic and Reconstructive Surgery. Global Open
Araya Zaesim, Viva Nguyen, Charles S Scarborough
Breast cancer in males represents a small proportion of all cancers diagnosed. Pure ductal carcinoma in situ (DCIS), a low-grade form of breast cancer, is even more rare in male patients. We present a case of a 47-year-old male patient with a tender breast lump that was noted for 6 months. He was subsequently found to have a low grade, pure micropapillary and cribriform type DCIS with no evidence of invasive disease. Current literature does not provide distinct guidelines regarding management of male breast cancer, and it is currently managed in a similar fashion to female breast cancer...
May 2018: Journal of Surgical Case Reports
Hye Rin Kim, Hae Kyoung Jung
Background: There is little research done on non-mass cancers (NMCs) on breast ultrasound (US). Purpose: To evaluate large-sectional histopathology findings of NMCs on breast US. Material and Methods: The mammographic and histopathology features of biopsy proven 36 breast cancers which showed pure non-mass lesions on US were retrospectively reviewed. Results: The most common mammographic finding was microcalcification (23/35, 65...
June 2018: Acta Radiologica Open
Pierpaolo Pattacini, Andrea Nitrosi, Paolo Giorgi Rossi, Valentina Iotti, Vladimiro Ginocchi, Sara Ravaioli, Rita Vacondio, Luca Braglia, Silvio Cavuto, Cinzia Campari
Purpose To compare digital mammography (DM) plus digital breast tomosynthesis (DBT) versus DM alone for breast cancer screening in the Reggio Emilia Tomosynthesis trial, a two-arm test-and-treat randomized controlled trial. Materials and Methods For this trial, eligible women (45-70 years old) who previously participated in the Reggio Emilia screening program were invited for mammography. Consenting women were randomly assigned 1:1 to undergo DBT+DM or DM (both of which involved two projections and double reading)...
June 5, 2018: Radiology
Swati Gupta, Navin R Mani, Daniel E Carvajal-Hausdorf, Veerle Bossuyt, Kenneth Ho, Jodi Weidler, Wendy Wong, Brian Rhees, Michael Bates, David L Rimm
An on-demand, closed RT-qPCR, the GeneXpert (GX) system, has the potential to provide biomarker information in low-resourced settings and elsewhere. We used this system with a research use only version of the Breast Cancer STRAT4 cartridge that measures the mRNA expression levels of ERBB2, ESR1, PGR, and MKi67. Here we evaluated the impact of non-macrodissected (non m-d) versus macrodissected (m-d) samples using STRAT4 on formalin-fixed, paraffin-embedded (FFPE) core needle biopsies. Two cohorts were assessed: (1) 60 FFPE infiltrating ductal carcinoma (IDCA) cases and (2) 20 FFPE IDCA cases with ductal carcinoma in situ (DCIS) with a range of HER2 expression as determined by clinical immunohistochemistry and fluorescence in situ hybridization (IHC/FISH)...
June 1, 2018: Laboratory Investigation; a Journal of Technical Methods and Pathology
Bao-Hua Yu, Bai-Zhou Li, Xiao-Yan Zhou, Da-Ren Shi, Wen-Tao Yang
BACKGROUND: Nuclear forkhead box protein P1 (N-FOXP1) expression in invasive breast cancer has been documented in the literature. However, the FOXP1 expression patterns at different stages of breast cancer progression are largely unknown, and the significance of cytoplasmic FOXP1 (C-FOXP1) expression in breast cancer has not been well illustrated. The aims of this study were to investigate FOXP1 expression patterns in invasive ductal carcinoma (IDC), ductal carcinoma in situ (DCIS), atypical ductal hyperplasia (ADH) and usual ductal hyperplasia (UDH), and to analyze the clinicopathological relevance of C-FOXP1 and its prognostic value in IDC...
May 30, 2018: Diagnostic Pathology
Guan-Yu Chen, Hua-Chuan Zheng
BACKGROUND: Dkk3 protein attenuates the expression of Wnt3a, Wnt5a and LRP6, and their interaction, and interacts with βTrCP to suppress wnt/β-catenin pathway. METHODS: We performed a bioinformatics analysis of Dkk3 mRNA expression through Oncomine, TCGA and Kaplan-Meier databases up to July 10, 2017. RESULTS: Up-regulated Dkk3 expression was higher in gastric, breast, and ovarian cancers than normal tissues (p< 0.05). Bitter's database showed a higher Dkk3 expression in ovarian cytoadenocarcinoma than clear cell adenocarcinoma (p< 0...
May 11, 2018: Cancer Biomarkers: Section A of Disease Markers
Zbigniew Jodkiewicz, Andrzej Cichocki, Sebastian Rybski, Wojciech Michalski, Barbara Kozakiewicz, Barbara Trzaska, Katarzyna Roszkowska, Łukasz Sawicki
AIM: The aim of the study was to analyze long term results and prognostic factors in women with preinvasive breast cancer (DCIS - ductal carcinoma in situ) who underwent breast conserving surgery with subsequent radiotherapy. MATERIALS AND METHODS: A total number of 106 patients was analyzed aged 29-78 years; mean age was 54,3 years and median 55 years. In 78 (73,5%) patients the tumor was diagnosed incidentally on mammography or ultrasound scan, 28 (26,5%) had palpable lesion...
May 25, 2018: Polski Merkuriusz Lekarski: Organ Polskiego Towarzystwa Lekarskiego
Stefano Volinia, Valeria Bertagnolo, Silvia Grassilli, Federica Brugnoli, Marco Manfrini, Marco Galasso, Cristian Scatena, Chiara Maria Mazzanti, Francesca Lessi, Giuseppe Naccarato, Adelaide Caligo, Enzo Bianchini, Quirino Piubello, Enrico Orvieto, Massimo Rugge, Cristina Natali, Domenico Reale, Andrea Vecchione, Sarah Warner, Carlo Maria Croce, Silvano Capitani
A substantial number of ductal carcinoma in situ (DCIS) detected by mammography never progress to invasive ductal carcinoma (IDC) and current approaches fail to identify low-risk patients not at need of adjuvant therapies. We aimed to identify the key miRNAs protecting DCIS from malignant evolution, that may constitute markers for non-invasive lesions. We studied 100 archived DCIS samples, including pure DCIS, DCIS with adjacent IDC and pure DCIS from patients with subsequent IDC in contralateral breast or no recurrence...
May 4, 2018: Oncotarget
Mio Yoshikawa, Hisae Iinuma, Yasuko Umemoto, Takako Yanagisawa, Akiko Matsumoto, Hiromitsu Jinno
Patients diagnosed preoperatively with ductal carcinoma in situ (DCIS) breast cancer have the potential to develop invasive ductal carcinoma (IDC). The present study investigated the usefulness of exosome-encapsulated microRNA-223-3p (miR-223-3p) as a biomarker for detecting IDC in patients initially diagnosed with DCIS by biopsy. The potential association between miR-223-3p and clinicopathological characteristics was examined in patients with breast cancer. Exosomes of 185 patients with breast cancer were separated from plasma by ultracentrifugation...
June 2018: Oncology Letters
Qiuting You, Kai Chen, Yudong Li, Jianguo Lai, Yichao Fang, Shiyu Shen, Yicheng Liu, Fengxi Su, Fengyan Yu
PURPOSE: Our study aimed to investigate the factors influencing trends of contralateral prophylactic mastectomy (CPM) among patients with unilateral ductal carcinoma in situ (DCIS). PATIENTS AND METHODS: We used the Surveillance, Epidemiology, and End Results (SEER) data to identify patients with unilateral DCIS diagnosed from 1998 to 2013. Patients were categorized as breast-conserving surgery (BCS), Unilateral Mastectomy and CPM group. Univariate and multivariate logistic regressions were applied to assess the factors associated with undergoing CPM among mastectomy patients...
May 22, 2018: Breast: Official Journal of the European Society of Mastology
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