keyword
MENU ▼
Read by QxMD icon Read
search

Ductal carcinoma in situ

keyword
https://www.readbyqxmd.com/read/28724885/invasive-ductal-carcinoma-within-a-benign-phyllodes-tumor
#1
Nancy Panko, Anwar A Jebran, Ameer Gomberawalla, Mark Connolly
BACKGROUND Phyllodes tumor (PT) is a rare neoplasm of the breast. Concomitant PT with invasive ductal carcinoma (IDC) is an even rarer occurrence. When ductal carcinoma in situ (DCIS) or IDC are detected within the specimen, the management changes from wide local excision to further staging work-up, including sentinel node biopsy and radiation. CASE REPORT We report the case of a 70-year-old presented with right breast mass whose pathology showed benign PT with concomitant IDC and DCIS. The patient elected for a wide excision of the mass with sentinel lymph node biopsy, which did not show any involvement...
July 20, 2017: American Journal of Case Reports
https://www.readbyqxmd.com/read/28721885/nrg-oncology-radiation-therapy-oncology-group-study-1014-1-year-toxicity-report-from-a-phase-2-study-of-repeat-breast-preserving-surgery-and-3-dimensional-conformal-partial-breast-reirradiation-for-in-breast-recurrence
#2
Douglas W Arthur, Kathryn A Winter, Henry M Kuerer, Bruce G Haffty, Laurie W Cuttino, Dorin A Todor, Nicole L Simone, Shelly B Hayes, Wendy A Woodward, Beryl McCormick, Randi J Cohen, Walter M Sahijdak, Daniel J Canaday, Doris R Brown, Adam D Currey, Christine M Fisher, Reshma Jagsi, Julia White
PURPOSE: To determine the associated toxicity, tolerance, and safety of partial-breast reirradiation. METHODS AND MATERIALS: Eligibility criteria included in-breast recurrence occurring >1 year after whole-breast irradiation, <3 cm, unifocal, and resected with negative margins. Partial-breast reirradiation was targeted to the surgical cavity plus 1.5 cm; a prescription dose of 45 Gy in 1.5 Gy twice daily for 30 treatments was used. The primary objective was to evaluate the rate of grade ≥3 treatment-related skin, fibrosis, and/or breast pain adverse events (AEs), occurring ≤1 year from re-treatment completion...
August 1, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/28711544/concordance-of-dna-methylation-profiles-between-breast-core-biopsy-and-surgical-excision-specimens-containing-ductal-carcinoma-in-situ-dcis
#3
Youdinghuan Chen, Jonathan D Marotti, Erik G Jenson, Tracy L Onega, Kevin C Johnson, Brock C Christensen
The utility and reliability of assessing molecular biomarkers for translational applications on pre-operative core biopsy specimens assume consistency of molecular profiles with larger surgical specimens. Whether DNA methylation in ductal carcinoma in situ (DCIS), measured in core biopsy and surgical specimens are similar, remains unclear. Here, we compared genome-scale DNA methylation measured in matched core biopsy and surgical specimens from DCIS, including specific DNA methylation biomarkers of subsequent invasive cancer...
July 12, 2017: Experimental and Molecular Pathology
https://www.readbyqxmd.com/read/28709865/overexpression-of-pofut1-and-activated-notch1-may-be-associated-with-poor-prognosis-in-breast-cancer
#4
Guoxing Wan, Lin Tian, Yuandong Yu, Fang Li, Xuanbin Wang, Chen Li, Shouheng Deng, Xiongjie Yu, Xiaojun Cai, Zhigang Zuo, Fengjun Cao
PURPOSE: The present study was to evaluate the prognostic value of protein expression of Pofut1 and Notch1 signaling in breast cancer. MATERIAL AND METHODS: Formalin-fixed paraffin-embedded 314 breast specimens including 174 infiltrating ductal carcinoma(IDC), 50 ductal carcinoma in situ(DCIS) and 90 adjacent normal tissue(ANT) were immunohistochemically examined to evaluate the protein expression of Pofut1, activated Notch1(N1IC) and Slug on specimens. Survival analysis was performed by Kaplan-Meier method and Cox's proportional-hazards model...
July 11, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28707744/the-impact-of-molecular-subtype-on-breast-cancer-recurrence-in-young-women-treated-with-contemporary-adjuvant-therapy
#5
Hanan Alabdulkareem, Tiffany Pinchinat, Sarah Khan, Alyssa Landers, Paul Christos, Rache Simmons, Tracy-Ann Moo
Breast cancer is the leading cause of cancer death in women younger than 40 years. Triple-negative breast cancer (TNBC) and human epidermal growth factor receptor-2 (HER2) positive subtypes have a particularly poor prognosis in this age group. The purpose of this study was to compare rates of recurrence among breast cancer subtypes in young patients treated with modern adjuvant systemic therapy. A retrospective review of breast cancer patients managed at a major academic breast center between May 2000 and November 2014 was performed...
July 14, 2017: Breast Journal
https://www.readbyqxmd.com/read/28705686/imaging-features-of-patients-undergoing-active-surveillance-for-ductal-carcinoma-in-situ
#6
Lars J Grimm, Sujata V Ghate, E Shelley Hwang, Mary Scott Soo
RATIONALE AND OBJECTIVES: The aim of this study was to describe the imaging appearance of patients undergoing active surveillance for ductal carcinoma in situ (DCIS). MATERIALS AND METHODS: We retrospectively identified 29 patients undergoing active surveillance for DCIS from 2009 to 2014. Twenty-two patients (group 1) refused surgery or were not surgical candidates. Seven patients (group 2) enrolled in a trial of letrozole and deferred surgical excision for 6-12 months...
July 10, 2017: Academic Radiology
https://www.readbyqxmd.com/read/28705330/mucocoele-like-lesions-is-surgical-excision-still-necessary
#7
I Dash, B Dessauvagie, M Hardie, C Saunders, E Wylie
AIM: To assess the rate of upgrade in our screening population to determine whether open excision biopsy of mucocoele-like lesions (MLL) is still required. MATERIALS AND METHODS: A retrospective review of the breast screening database from 1999-2014 was performed. RESULTS: MLL were identified on core biopsy in 113 women (0.6% of those recalled for a core biopsy). The majority (n=100, 88%) had a localised cluster of calcification prompting screening recall...
July 10, 2017: Clinical Radiology
https://www.readbyqxmd.com/read/28700803/factors-associated-with-underestimation-of-invasive-cancer-in-patients-with-ductal-carcinoma-in-situ-precautions-for-active-surveillance
#8
Carlos Chavez de Paz Villanueva, Valentina Bonev, Maheswari Senthil, Naveenraj Solomon, Mark E Reeves, Carlos A Garberoglio, Jukes P Namm, Sharon S Lum
Importance: Recent recognition of the overdiagnosis and overtreatment of ductal carcinoma in situ (DCIS) detected by mammography has led to the development of clinical trials randomizing women with non-high-grade DCIS to active surveillance, defined as imaging surveillance with or without endocrine therapy, vs standard surgical care. Objective: To determine the factors associated with underestimation of invasive cancer in patients with a clinical diagnosis of non-high-grade DCIS that would preclude active surveillance...
July 12, 2017: JAMA Surgery
https://www.readbyqxmd.com/read/28700354/docking-of-cdk1-with-antibiotic-drugs-revealed-novel-therapeutic-value-in-breast-ductal-cancer-in-situ
#9
Zhong-Hai Ding, Jia Qi, An-Quan Shang, Yu-Jie Zhang, Jun Wei, Li-Qing Hu, Wei-Wei Wang, Man Yang
The aim of our research is to identify potential genes associated with Ductal carcinoma in situ (DCIS) through microarrays. The microarray dataset GS54665 were downloaded from the GEO(Gene Expression Omnibus) database. Dysregulated genes were screened and their associations with DCIS was analyzed by comprehensive bioinformatics tools. A total of 649 differential expression genes were identified between normal and DCIS samples, including 224 up-regulated genes and 425 down-regulated genes. Biological process annotation and pathway enrichment analysis identified several DCIS-related signaling pathways...
June 28, 2017: Oncotarget
https://www.readbyqxmd.com/read/28698318/words-do-matter-a-systematic-review-on-how-different-terminology-for-the-same-condition-influences-management-preferences
#10
Brooke Nickel, Alexandra Barratt, Tessa Copp, Ray Moynihan, Kirsten McCaffery
OBJECTIVES: Changing terminology for low-risk, screen-detected conditions has now been recommended by several expert groups in order to prevent overdiagnosis and reduce the associated harms of overtreatment. However, the effect of terminology on patients' preferences for management is not well understood. This review aims to synthesise existing studies on terminology and its impact on management decision making. DESIGN: Systematic review. METHODS: Studies were included that compared two or more terminologies to describe the same condition and measured the effect on treatment or management preferences and/or choices...
July 10, 2017: BMJ Open
https://www.readbyqxmd.com/read/28695812/clinical-and-sonographic-features-of-mammary-paget-s-disease
#11
Yao Wei, Qingli Zhu, Jianchu Li, Yuxin Jiang
Objective To summarize the clinical and sonographic features of mammary Paget's disease (MPD). Methods Totally 34 female patients with pathologically confirmed MPD were retrospectively recruited. According to diagnosis,the clinical data and sonographic findings were reviewed and analyzed. Results Among these 34 patients,7 patients had single MPD; in the remaining 27 patients,16 were accompanied by invasive ductal carcinoma (IDC),7 by ductal carcinoma in situ (DCIS),3 by both IDC and DCIS,and 1 by other pathologic types of carcinoma...
June 20, 2017: Zhongguo Yi Xue Ke Xue Yuan Xue Bao. Acta Academiae Medicinae Sinicae
https://www.readbyqxmd.com/read/28692660/n-3-oxododecanoyl-l-homoserine-lactone-interactions-in-the-breast-tumor-microenvironment-implications-for-breast-cancer-viability-and-proliferation-in-vitro
#12
Brittany N Balhouse, Logan Patterson, Eva M Schmelz, Daniel J Slade, Scott S Verbridge
It is well documented that the tumor microenvironment profoundly impacts the etiology and progression of breast cancer, yet the contribution of the resident microbiome within breast tissue remains poorly understood. Tumor microenvironmental conditions, such as hypoxia and dense tumor stroma, predispose progressive phenotypes and therapy resistance, however the role of bacteria in this interplay remains uncharacterized. We hypothesized that the effect of individual bacterial secreted molecules on breast cancer viability and proliferation would be modulated by these tumor-relevant stressors differentially for cells at varying stages of progression...
2017: PloS One
https://www.readbyqxmd.com/read/28691862/simplifying-breast-imaging-reporting-and-data-system-classification-of-mammograms-with-pure-suspicious-calcifications
#13
Gisela Lg Menezes, Gonneke Ao Winter-Warnars, Eva L Koekenbier, Emma J Groen, Helena M Verkooijen, Ruud M Pijnappel
Objectives To investigate the risk of malignancy following stereotactic breast biopsy of calcifications classified as Breast Imaging Reporting and Data System (BI-RADS) 3, 4, and 5. Methods The study included women with pure calcifications (not associated with masses or architectural distortions) who underwent stereotactic breast biopsy at the Dutch Cancer Institute between January 2011 and October 2013. Suspicious calcifications (Breast Imaging Reporting and Data System 3, 4, or 5) detected on mammography were biopsied...
January 1, 2017: Journal of Medical Screening
https://www.readbyqxmd.com/read/28690657/epigenetic-silencing-of-mort-is-an-early-event-in-cancer-and-is-associated-with-luminal-receptor-positive-breast-tumor-subtypes
#14
Lukas Vrba, Bernard Walter Futscher
Immortality is an essential characteristic of cancer cells; a recent transcriptomic study of epithelial cell immortalization has linked epigenetic silencing of the long noncoding RNA Mortal Obligate RNA Transcript (MORT; alias ZNF667-AS1) to this process. This study evaluated the epigenetic and transcriptional state of MORT in two premalignant conditions-ductal carcinomas in situ and colon adenomas. Results show that MORT silencing is an early epigenetic event in human carcinogenesis, likely occurring near the point where premalignant cells gain immortality; this epigenetic silencing is maintained throughout malignant transformation and metastatic growth...
June 2017: Journal of Breast Cancer
https://www.readbyqxmd.com/read/28690655/screening-uptake-differences-are-not-implicated-in-poorer-breast-cancer-outcomes-among-singaporean-malay-women
#15
Wong Ru Xin, Li-Lian Kwok, Wong Fuh Yong
PURPOSE: This study was undertaken to examine the impact of screening and race on breast cancer outcomes in Singapore. METHODS: An institutional database was reviewed, and invasive ductal carcinoma (IDC) and ductal carcinoma in situ (DCIS) data were analyzed separately. Overall survival (OS), disease-free survival (DFS), and cancer-specific survival (CSS) were assessed. RESULTS: The study included 6,180 IDC and 1,031 DCIS patients. The median follow-up time was 4...
June 2017: Journal of Breast Cancer
https://www.readbyqxmd.com/read/28690654/the-usefulness-of-intraoperative-circumferential-frozen-section-analysis-of-lumpectomy-margins-in-breast-conserving-surgery
#16
SeungSang Ko, Yi Kyeong Chun, Sung Soo Kang, Min Hee Hur
PURPOSE: Intraoperative frozen-section analysis of the lumpect-omy margin during breast-conserving surgery (BCS) is an excellent method in obtaining a clear resection margin. This study aimed to investigate the usefulness of intraoperative circumferential frozen-section analysis (IOCFS) of lumpectomy margin during BCS for breast cancer, and to find factors that increase the conversion into mastectomy. METHODS: From 2007 to 2011, 509 patients with breast cancer underwent IOCFS during BCS...
June 2017: Journal of Breast Cancer
https://www.readbyqxmd.com/read/28690051/nipple-sparing-mastectomy-for-breast-cancer-is-associated-with-high-patient-satisfaction-and-safe-oncological-outcomes
#17
V Mesdag, C Régis, E Tresch, M-P Chauvet, L Boulanger, P Collinet, S Giard
BACKGROUND: The preservation of the nipple areolar complex (NAC) for cancer treatment is still a matter of debate because of suspected increase of local recurrence and surgery-specific complications. The aim of the study was to investigate both the relapse risk associated with nipple sparing mastectomy (NSM) for breast cancer and women's satisfaction with preservation of the NAC. METHODS: We included retrospectively all patients who had skin-sparing mastectomy (SSM) or NSM from 2007 to 2012 for breast cancer or ductal carcinoma in situ (DCIS)...
July 8, 2017: Journal of gynecology obstetrics and human reproduction
https://www.readbyqxmd.com/read/28689011/coexistence-of-ductal-carcinoma-within-mammary-phyllodes-tumor-a-review-of-557-cases-from-a-20-year-region-wide-database-in-hong-kong-and-southern-china
#18
Michael Co, Gary M Tse, Clement Chen, Jiannan Wei, Ava Kwong
INTRODUCTION: Phyllodes tumor (PT) is an uncommon fibroepithelial tumor of the breast showing predominately proliferation of the stromal component. The presence of ductal carcinoma in situ (DCIS) or invasive ductal carcinoma is rare, with only a few cases reported in the literature. METHODS: A retrospective review of a prospectively maintained database was performed. Patients who were treated for PT in 5 hospitals in Hong Kong and Shenzhen, China over a period of 20 years (1997-2016) were evaluated...
June 17, 2017: Clinical Breast Cancer
https://www.readbyqxmd.com/read/28687431/resectable-invasive-ipmn-versus-sporadic-pancreatic-adenocarcinoma-of-the-head-of-the-pancreas-should-these-two-different-diseases-receive-the-same-treatment-a-matched-comparison-study-of-the-french-surgical-association-afc
#19
P Duconseil, J Périnel, A Autret, M Adham, A Sauvanet, L Chiche, J-Y Mabrut, J-J Tuech, C Mariette, N Régenet, J-M Fabre, P Bachellier, J-R Delpéro, F Paye, O Turrini
PURPOSE: To compare survival and impact of adjuvant chemotherapy in patients who underwent pancreaticoduodenectomy (PD) for invasive intraductal papillary mucinous neoplasm (IIPMN) and sporadic pancreatic ductal adenocarcinoma (PDAC). METHODS: From 2005 to 2012, 240 patients underwent pancreatectomy for IIPMN and 1327 for PDAC. Exclusion criteria included neoadjuvant treatment, pancreatic resection other than PD, vascular resection, carcinoma in situ, or <11 examined lymph nodes...
June 29, 2017: European Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28685877/availability-of-immunocytochemistry-using-cocktail-antibody-targeting-p63-cytokeratin14-for-the-differential-diagnosis-of-fibroadenoma-and-ductal-carcinoma-in-situ-in-fine-needle-aspiration-cytology-of-the-breast
#20
I Maeda, Y Oana, K Tsugawa, M Takagi
OBJECTIVE: The differential diagnosis of fibroadenoma (FA) and ductal carcinoma in situ (DCIS) has been problematic in fine needle aspiration biopsy (FNAC) because it has been difficult to differentiate between the "large epithelial clusters" associated with FA and those associated with DCIS. The purpose of this study was to prospectively validate the usefulness of immunocytochemical staining using cocktail antibody targeting p63/CK14 in the differential diagnosis of FA and DCIS. MATERIALS AND METHODS: Twenty patients diagnosed as having an uncertain malignant potential (indeterminate) for breast cancer on the basis of a FNAC finding were selected randomly: ten patients with FA and ten with DCIS...
July 6, 2017: Cytopathology: Official Journal of the British Society for Clinical Cytology
keyword
keyword
6249
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"