Ego states

AIMS: To investigate the safety, tolerability, pharmacokinetics (PK) and pharmacodynamics (PD) of BPL-003, a novel intranasal benzoate salt formulation of 5-methoxy- N,N -dimethyltryptamine (5-MeO-DMT), in healthy participants. METHODS: In all, 44 psychedelic-naïve participants enrolled in the double-blind, placebo-controlled single ascending dose study (1-12 mg BPL-003). Concentrations of 5-MeO-DMT and its pharmacologically active metabolite, bufotenine, were determined in plasma and urine...

AIM: This research aimed to assess the impact of the online "Positive Psychotherapy- Based Key Model of Courtesy and Integrity" (KMCI)" program on the effective communication skills of nursing students. BACKGROUND: With the growing integration of virtual platforms in psychotherapy education, there is a burgeoning interest in understanding their influence on nursing student's communication abilities. Recognizing how online positive psychotherapy education shapes these skills is pivotal for enriching nursing education and practice...

Classic psychedelics are able to profoundly alter the state of consciousness and lead to acute experiences of ego dissolution - the blurring of the distinction between representations of self and the external world. However, whether repeated use of psychedelics is associated with more prolonged and permanent modifications to the concept of self remains to be investigated. Therefore, we conducted a preregistered, cross-sectional study in which experienced psychedelics users (15 or more lifetime experiences with psychedelics; N = 56) were compared to nonusers (N = 57) in terms of neural reactivity to a Self-name (i...

Psychiatry is in a growth phase in which several psychedelic medicines have entered its arena with great promise. Of these, presently, ketamine is the only medicine that may be legally prescribed. We hypothesize that at subanesthetic doses, ketamine produces a unique spectrum of altered states, ranging from psychoactive to deep ego-dissolving experiences, that are intrinsic to ketamine's therapeutic effects. When these experiences are embedded in a therapeutic relationship-a setting-that fosters an amplification of the recipient's subjective consciousness, personal growth, inner healing, greater clarity, and better relationships may well ensue...

UNLABELLED: Femoral nerve damage, especially in proximal retroperitoneal space, is rare. Therefore, surgical strategy is still unclear for these patients. Various specialists discuss repair with autografts or neurotization by the obturator nerve or its muscular branch. OBJECTIVE: To demonstrate the diagnostic algorithm for proximal femoral nerve injury and favorable outcomes after repair with long autografts. MATERIAL AND METHODS: We assessed movements and sensitivity using a five-point scale, as well as ultrasound, magnetic resonance imaging and electroneuromyography data in a patient with extended iatrogenic femoral nerve damage before and after repair with long autografts (10...

AIM: Psychedelics have recently gained attention as potential therapeutic agents for various psychiatric disorders. Previous research has highlighted that a diminished sense of self, commonly termed "ego-dissolution" is a pivotal feature of the psychedelic-induced state. While the Ego-Dissolution Inventory (EDI) is a widely acknowledged instrument for measuring this phenomenon, no Japanese version has been available. This study aimed to develop a Japanese version of the EDI. METHODS: We adhered to the "Guidelines for Best Practices in the Translation and Cultural Modification Process for Patient-Reported Outcomes Instruments: Document from the ISPOR Committee on Translation and Cultural Modification" during our translation approach...

The pervasive use of social media in professional environments has become a focal point of contemporary research. Particularly, the routine engagement of employees with platforms like Facebook and WeChat during work hours exposes them to peers' achievements, potentially triggering upward social comparisons. This study investigates the often-overlooked psychological and behavioral consequences of such comparisons among employees in workplace settings. Specifically, we address a significant research gap by examining how upward social comparisons on social media influence employees' emotions and subsequent workplace behaviors...

Adaptive cruise control and autonomous lane-change systems represent pivotal advancements in intelligent vehicle technology. To enhance the operational efficiency of intelligent vehicles in combined lane-change and car-following scenarios, we propose a coordinated decision control model based on hierarchical time series prediction and deep reinforcement learning under the influence of multiple surrounding vehicles. Firstly, we analyze the lane-change behavior and establish boundary conditions for safe lane-change, and divide the lane-change trajectory planning problem into longitudinal velocity planning and lateral trajectory planning...

Ego-vehicle state prediction represents a complex and challenging problem for self-driving and autonomous vehicles. Sensorial information and on-board cameras are used in perception-based solutions in order to understand the state of the vehicle and the surrounding traffic conditions. Monocular camera-based methods are becoming increasingly popular for driver assistance, with precise predictions of vehicle speed and emergency braking being important for road safety enhancement, especially in the prevention of speed-related accidents...

Bone is continuously in a state of building and renewal, though the process of remodeling that takes place at many sites asynchronously throughout the skeleton, with bone formation and resorption equal at these sites (bone multicellular units). Remodeling takes place on bone surfaces, both on trabeculae and in the cortex, and serves the purposes of replacing old bone or that damaged by microfractures throughout the skeleton. The bone loss and consequent osteoporotic fractures that result from excess resorption over formation have mainly been prevented or treated by antiresorptive drugs that inhibit osteoclast formation and/or activity...

When asked to estimate how much their state or nation has contributed to history, people typically provide unreasonably large estimates, claiming that their group has contributed much more to history than nongroup members would estimate, demonstrating collective overclaiming. Why does such overclaiming occur? In the current study we examined factors that might predict collective overclaiming. Participants from 12 U.S. states estimated how much their home state contributed to U.S. history, completed measures of collective narcissism and numeracy, and rated the importance of 60 specific historical events...

We propose a novel end-to-end method for cross-view pose estimation. Given a ground-level query image and an aerial image that covers the query's local neighborhood, the 3 Degrees-of-Freedom camera pose of the query is estimated by matching its image descriptor to descriptors of local regions within the aerial image. The orientation-aware descriptors are obtained by using a translationally equivariant convolutional ground image encoder and contrastive learning. The Localization Decoder produces a dense probability distribution in a coarse-to-fine manner with a novel Localization Matching Upsampling module...

The study addresses the question whether professional gamblers can be considered an occupational group from a sociological perspective. It combines survey data on poker players from the German state North Rhine-Westphalia with sociological theory in order to explain the oxymoron of professional gambling. The descriptive analysis of the survey data is supplemented by ego-centric network data of the poker players to analyze whether hobby and professional players maintain different forms of social relationships...

In this note I have limited myself to describing some convergent and divergent developments arising from the innovative concepts present in The Ego and the Id. It could be argued that a part of the psychoanalytic movement wished to emphasize the function of the Ego (Anna Freud, Hartmann, Rapaport), while another part (Melanie Klein and her followers) delved into the dynamics of the Superego and the Id in primitive and pathological states of mind. I will examine three themes presents in The Ego and the Id: the assertion that a part of the Ego is unconscious; the idea that the death drive becomes part of the dynamics of melancholia and its Superego; the concept of fusion and defusion of the life and death instinct...

The psychoanalytic journey and the psilocybin journey both reveal unconscious dynamics. In this article a psychoanalyst discusses his own psilocybin journey. Similarities and differences between these journeys are discussed. Possibilities are offered for a dialogue in which psilocybin may contribute to psychoanalytic understanding and psychoanalysis may contribute to the understanding of psychedelic sessions. Patients may benefit from this cross-fertilization.

Is to study a 2, 4, 6-trinitrophenol (2.4,6-TNP) distribution in warm-blooded animals using physical chemical analysis methods after intragastric injection of toxicant. The methods of thin-layer chromatography, spectrophotometry and high-efficient liquid chromatography were used in the study process. Four-months-old rats of the Wistar line (males) were considered as a model of warm-blooded organisms. The investigated substance in amount of three-times LD50 was intragastrically injected in the aqueous-suspension state...

Relaxometry is a field with a glorious and controversial history, and no review will ever do it justice. It is full of egos and inventions, patents and lawsuits, high expectations and deep disillusionments. Rather than a paragraph dedicated to each of these, we want to give it an impressionistic overview, painted over with a coat of personal opinions and ruminations about the future of the field. For those unfamiliar with the Gartner hype cycle, here's a brief recap. The cycle starts with a technology trigger and goes through a phase of unrealistically inflated expectations...

Establishing an accurate and computationally efficient model for driving risk assessment, considering the influence of vehicle motion state and kinematic characteristics on path planning, is crucial for generating safe, comfortable, and easily trackable obstacle avoidance paths. To address this topic, this paper proposes a novel dual-layered dynamic path-planning method for obstacle avoidance based on the driving safety field (DSF). The contributions of the proposed approach lie in its ability to address the challenges of accurately modeling driving risk, efficient path smoothing and adaptability to vehicle kinematic characteristics, and providing collision-free, curvature-continuous, and adaptable obstacle avoidance paths...

OBJECTIVE: This study aimed to assess the plausibility of self-control depletion, or ego-depletion, as the underlying cognitive resource responsible for performance decrements on the sustained attention to response task. BACKGROUND: Researchers suggested that self-control is a limited cognitive resource used to complete a myriad of processes, including sustained attention. Past research showed that trait self-control affects some sustained attention tasks. However, little research has investigated the effect of self-control as a limited cognitive resource that varies over time (i...

Rehabilitation Medicine and Palliative medicine have much in common as both specialties deal with loss and impending loss related to incurable medical conditions. Significant losses are encountered by patients in both rehabilitation and palliative care settings, and often threaten quality of life, hopefulness, and resiliency. The losses are related to what the patient has identified as self. In this article the author suggests a way of approaching loss and suffering that incorporates, mindfulness, Disidentification and Ego-State work to help preserve a sense of self that is not identified with what is happening to the body...