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Parkinson color visual

Tamara Shiner, Anat Mirelman, Mali Gana Weisz, Anat Bar-Shira, Elissa Ash, Ron Cialic, Naomi Nevler, Tanya Gurevich, Noa Bregman, Avi Orr-Urtreger, Nir Giladi
Importance: Mutations in the glucocerebrosidase (GBA) gene are a risk factor for the development of dementia with Lewy bodies (DLB). These mutations are common among Ashkenazi Jews (AJ) and appear to have an effect on the natural history of the disease. Objectives: To evaluate the clinical and genetic characteristics of an AJ cohort of patients diagnosed with DLB, assess the association of phenotype of DLB with GBA mutations, and explore the effects of these mutations on the clinical course of the disease...
October 10, 2016: JAMA Neurology
(no author information available yet)
This conference was conceived in 1991 when a small group of individuals envisioned how virtual reality, then in its first era of widespread enthusiasm, might transform medicine by immersing physicians, students, and patients in data more completely. They predicted that interactive learning tools might better engage medical students by assessing real-time performance and customizing lessons in sync. Simulation could enhance the "see one, do one, teach one" model with the repetition that athletes and musicians used to perfect their skills...
2016: Studies in Health Technology and Informatics
Hohee Son, Eunjung Kim
[Purpose] To investigate the role of external cues on arm swing amplitude and trunk rotation in Parkinson's disease. [Subjects and Methods] The subjects were 13 elderly patients with Parkinson's disease. Subjects walked under four different conditions in a random order: no cue, visual cue, auditory cue, and combined cue. The auditory cue velocity consisted of a metronome beat 20% greater than the subject's general gait speed. For the visual cue condition, bright yellow colored strips of tape placed on the floor at intervals equal to 40% of each subject's height...
December 2015: Journal of Physical Therapy Science
Xiang Li, Xu Li, Yi-Xiang Li, Yuan Zhang, Di Chen, Ming-Zhu Sun, Xin Zhao, Dong-Yan Chen, Xi-Zeng Feng
We describe an interdisciplinary comparison of the effects of acute and chronic alcohol exposure in terms of their disturbance of light, dark and color preferences and the occurrence of Parkinson-like behavior in zebrafish through computer visual tracking, data mining, and behavioral and physiological analyses. We found that zebrafish in anxiolytic and anxious states, which are induced by acute and chronic repeated alcohol exposure, respectively, display distinct emotional reactions in light/dark preference tests as well as distinct learning and memory abilities in color-enhanced conditional place preference (CPP) tests...
2015: PloS One
Carlos E Mendoza-Santiesteban, Jose-Alberto Palma, Jose Martinez, Lucy Norcliffe-Kaufmann, Thomas R Hedges, Horacio Kaufmann
BACKGROUND: Objective measures of disease progression that can be used as endpoints in clinical trials of MSA are necessary. We studied retinal thickness in patients with MSA and assessed changes over time to determine its usefulness as an imaging biomarker of disease progression. METHODS: This was a cross-sectional study including 24 patients with MSA, 20 with PD, and 35 controls, followed by a longitudinal study of 13 MSA patients. Patients were evaluated with high-definition optical coherence tomography and the Unified Multiple System Atrophy Rating Scale...
December 2015: Movement Disorders: Official Journal of the Movement Disorder Society
E Yu Fedotova, A O Chechetkin, N Yu Abramycheva, L A Chigaleychik, B Kh Baziyan, Т А Ponomareva, N S Alexeeva, P A Fedin, M A Kravchenko, Yu Ya Varakin, I A Ivanova-Smolenskaya, S N Illarioshkin
AIM: To work out an optimal algorithm to identify people at the latent stage of neurodegenerative process of «parkinsonian» type in the Russian population. MATERIAL AND METHODS: Authors launched a two-step study aimed at identifying people at the latent stage of Parkinson's disease (PD) in the Russian population - the PARKINLAR (PARKINsonism, LAtent stage, Russia). As the first step, we formed a group of «primary risk» by the identification in neurologically healthy people of at least one of the following confirmed PD risk factors: a) the substantia nigra hyperechogenicity (ultrasound screening was performed in 193 people); b) mutations in «parkinsonian» genes (genetic screening was performed in 29 relatives of PD patients from families with LRRK2, PARK2 and GBA mutations)...
2015: Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova
Manpreet Kaur, Rohit Saxena, Digvijay Singh, Madhuri Behari, Pradeep Sharma, Vimla Menon
BACKGROUND: To evaluate structural changes in the retina and correlate those with visual function measurements in patients with Parkinson disease (PD). METHODS: A cross-sectional comparative study of 20 patients with PD and 20 age-matched healthy controls was conducted. Visual acuity, color vision, contrast sensitivity, visual fields, pattern visual-evoked response (VER), and multifocal electroretinogram were recorded to determine functional change, whereas structural changes were evaluated with retinal nerve fiber layer (RNFL) thickness, macular thickness, macular volume, and ganglion cell-inner plexiform layer complex (GCL-IPL) thickness using spectral domain ocular coherence tomography (SD-OCT)...
September 2015: Journal of Neuro-ophthalmology: the Official Journal of the North American Neuro-Ophthalmology Society
Barbara Nowacka, Wojciech Lubinski, Krystyna Honczarenko, Andrzej Potemkowski, Krzysztof Safranow
BACKGROUND: The aim of this study was to determine the type and frequency of ophthalmologic changes occurring in patients with Parkinson disease (PD). MATERIAL/METHODS: One hundred consecutive patients (196 eyes) with idiopathic PD and a control group consisting of 100 healthy patients (196 eyes) matched for age and sex underwent a complete ophthalmological examination of both eyes, including assessment of patient medical history, dry eye questionare, and visual hallucinations questionnaire, distance and near best corrected visual acuity (DBCVA, NBCVA), color vision, distance photopic contrast sensitivity, near point of convergence, slit lamp examination of the eye anterior segment, tear film osmolarity and breakup time, aqueous tear production, and intraocular pressure, as well as fundus examination and evaluation of the perimacular retinal thickness (RT) and peripapillary retinal nerve fiber layer (RNFL) thickness...
2014: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
Julius B M Anang, Jean-Francois Gagnon, Josie-Anne Bertrand, Silvia Rios Romenets, Veronique Latreille, Michel Panisset, Jacques Montplaisir, Ronald B Postuma
OBJECTIVE: We investigated an array of possible markers of early dementia in Parkinson disease. METHODS: We performed a comprehensive assessment of autonomic, sleep, psychiatric, visual, olfactory, and motor manifestations in 80 patients with Parkinson disease who were dementia-free at baseline. After 4.4 years' follow-up, patients were evaluated for dementia. Predictive variables were assessed using logistic regression adjusting for disease duration, follow-up duration, age, and sex...
September 30, 2014: Neurology
Rolf Verleger, Alexander Koerbs, Julia Graf, Kamila Śmigasiewicz, Henning Schroll, Fred H Hamker
Patients with Parkinson׳s disease (PD) respond more readily than healthy controls to irrelevant stimuli that contain task-relevant, response-priming features. This behavior may reflect oversensitivity to response-relevant features of irrelevant stimuli or failure to select relevant stimuli. To decide between these alternatives, we investigated in a "contingent-capture" paradigm whether PD patients are also oversensitive to task-relevant features that do not prime responses. PD patients and healthy controls had to report the orientation of bars in target color, presented among bars of other colors...
September 2014: Neuropsychologia
Liang Sun, Hui Zhang, Zhuqin Gu, Ming Cao, Dawei Li, Piu Chan
BACKGROUND: We conducted this study is to investigate the correlation between stereopsis dysfunction and color perception, as well as whether stereopsis impairment is associated with motor dysfunction in patients with Parkinson's disease (PD). METHOD: Our present study included 45 PD patients and 50 non-PD control patients attending the Movement Disorder Center at Xuanwu Hospital Capital Medical University in Beijing from July 2011 to November 2011. Neurologic evaluations and visual function assessments were conducted, and the results between two groups of patients were compared...
2014: European Journal of Medical Research
Jee-Young Lee, Jeeyun Ahn, Tae Wan Kim, Beom Seok Jeon
Visual symptoms are a common feature in patients with Parkinson's disease (PD), and retinal dopamine loss and dysfunctions in foveal vision have been described in PD patients. Because visual hallucination (VH) is a specific feature of PD which is differentiated from other parkinsonian disorders, defective visual information processing from both the central and peripheral pathways is suggested to be the pathophysiological mechanisms of VH in PD. Decreased visual acuity as well as impaired contrast sensitivity and color vision is known to be related to the appearance of VH in PD...
2014: Journal of Parkinson's Disease
Tomáš Sieger, Cecilia Bonnet, Tereza Serranová, Jiří Wild, Daniel Novák, Filip Růžička, Dušan Urgošík, Evžen Růžička, Bertrand Gaymard, Robert Jech
The oculomotor role of the basal ganglia has been supported by extensive evidence, although their role in scanning eye movements is poorly understood. Nineteen Parkinsońs disease patients, which underwent implantation of deep brain stimulation electrodes, were investigated with simultaneous intraoperative microelectrode recordings and single channel electrooculography in a scanning eye movement task by viewing a series of colored pictures selected from the International Affective Picture System. Four patients additionally underwent a visually guided saccade task...
2013: PloS One
Jiří Keller, Aaron M Rulseh, Arnošt Komárek, Iva Latnerová, Robert Rusina, Hana Brožová, Josef Vymazal
Fractional anisotropy (FA) is the most commonly used quantitative measure of diffusion in the brain. Changes in FA have been reported in many neurological disorders, but the implementation of diffusion tensor imaging (DTI) in daily clinical practice remains challenging. We propose a novel color look-up table (LUT) based on normative data as a tool for screening FA changes. FA was calculated for 76 healthy volunteers using 12 motion-probing gradient directions (MPG), a subset of 59 subjects was additionally scanned using 30 MPG...
2013: PloS One
J Kassubek, A Danek, K Del Tredici-Braak, M W Greenlee, E H Pinkhardt
Although dysfunction of the visual system and dysfunctional eye movements during sporadic Parkinson's disease have been reported for more than 40 years, they have never been the focus of early and/or differential diagnosis. To date Parkinson's disease-related α-synuclein aggregates, i.e., Lewy pathology, are not known to develop either in the retina or in other components of the visual system. In a clinical context it is currently possible to test the involvement of the respective functional systems by means of optical coherence tomography and video oculography...
August 2013: Der Nervenarzt
Gilles Fénelon
About one third of patients with Parkinson's disease (PD) experience hallucinations, mostly of a complex visual type, less often auditory or tactile. Minor hallucinatory phenomena, including sense of presence, passage hallucinations and visual illusions are frequent. Hallucinations primarily occur in a context of clear sensorium in patients with longstanding PD. They are more frequent in the evening or during the night. Insight in the hallucinatory nature of the phenomenon may be retained, partial, fluctuating, or abolished...
December 2006: Psychologie & Neuropsychiatrie du Vieillissement
Tomasz Tykocki, Anna Kornakiewicz, Tomasz Mandat, Paweł Nauman
Abnormalities in pain perception are a part of the clinical picture in Parkinson's disease (PD) and belong to the category of non-motor symptoms. Two groups of patients were included in this study: (i) an experimental group of 36 patients with PD who were eligible for subthalamic deep brain stimulation (the experimental group [EG]) and (ii) a control group (CG) of 34 patients with a space-occupying lesion who were admitted for a framed stereotactic biopsy. Stereotactic frame fixation was used in both groups as a nociceptive stimulus...
May 2013: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
M Satue, E Garcia-Martin, I Fuertes, S Otin, R Alarcia, R Herrero, M P Bambo, L E Pablo, F J Fernandez
PURPOSE: To demonstrate axonal loss in the retinal nerve fiber layer (RNFL) of patients with Parkinson's disease (PD) and to evaluate the ability of Fourier-domain optical coherence tomography (OCT) to detect RNFL degeneration and retinal thinning in these patients. METHODS: PD patients (n=100) and healthy subjects (n=100) were included in the study and underwent visual acuity, color vision, and OCT examinations using two next-generation Fourier-domain devices (Spectralis and Cirrus)...
April 2013: Eye
Gwendolyn Gramer, Birgit Förl, Christina Springer, Petra Weimer, Gisela Haege, Friederike Mackensen, Edith Müller, Hans Eberhard Völcker, Georg Friedrich Hoffmann, Martin Lindner, Hermann Krastel, Peter Burgard
BACKGROUND: In phenylketonuria presymptomatic treatment following newborn screening prevents severe mental and physical impairment. The reasons for subtle impairments of cerebral functions despite early treatment remain unclear. We assessed a broad spectrum of visual functions in early-treated patients with phenylketonuria and evaluated two hypotheses-the dopamine and the long-chain polyunsaturated fatty acids (LCPUFAs) depletion hypotheses. METHODS: Contrast sensitivity, colour vision, electroretinography, frequency doubling technology campimetry (FDT), and their relation with blood phenylalanine and docosahexaenoic acid levels were assessed in 36 patients with phenylketonuria and 18 age-matched healthy controls...
January 2013: Molecular Genetics and Metabolism
Atul Kumar Dwivedi, Kona Madhavinadha Prasad, Vishal Trivedi, Parameswar Krishnan Iyer
Because of the toxicity caused by the heme redox-active iron proteins, their elevated levels, localization, and accumulation in the brain, many forms of neurodegenerative diseases, such as Alzheimer's disease, Parkinson's disease, and Huntington's disease, occur as a result of which the brain becomes vulnerable to oxidative stress, ultimately resulting in neuronal death. An anionic water-soluble conjugated polyfluorene derivative poly(9,9-bis(6-sulfate hexyl) fluorene-alt-1,4-phenylene) sodium salt (P1) that binds Fe³⁺ proteins with very high selectivity and sensitivity is reported here...
November 2012: ACS Applied Materials & Interfaces
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