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Lipomatosis

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https://www.readbyqxmd.com/read/29758934/adipose-tissue-derived-stem-cells-from-affected-and-unaffected-areas-in-patients-with-multiple-symmetric-lipomatosis-show-differential-regulation-of-mtor-pathway-genes
#1
Oliver Felthaus, Teresa Schön, Daniel Schiltz, Thiha Aung, Britta Kühlmann, Friedrich Jung, Alexandra Anker, Silvan Klein, Lukas Prantl
BACKGROUND: Multiple symmetric lipomatosis is a rare disease characterized by the excessive growth of uncapsulated masses of adipose tissue. Although the etiology has yet to be elucidated, a connection to brown adipose tissue has been proposed recently. The mTOR pathway which is found to be regulated in lipomatous tissue as well as associated with brown adipose tissue can be inhibited by a compound called rapamycin. METHODS: We isolated adipose tissue derived stem cells from both affected and unaffected tissue and treated these cells with different concentrations of rapamycin...
2018: Clinical Hemorheology and Microcirculation
https://www.readbyqxmd.com/read/29745217/spinal-epidural-lipomatosis-a-rare-condition-with-unclear-etiology
#2
Pasquale Donnarumma, Lorenzo Nigro, Angela Ambrosone, Roberto Tarantino, Antonio Santoro, Roberto Delfini
No abstract text is available yet for this article.
May 9, 2018: Journal of Neurosurgical Sciences
https://www.readbyqxmd.com/read/29721861/lumbar-epidural-lipomatosis-is-associated-with-visceral-fat-and-metabolic-disorders
#3
Shingo Morishita, Yoshiyasu Arai, Toshitaka Yoshii, Kenichiro Sakai, Takashi Hirai, Atsushi Okawa
PURPOSE: Lumbar spinal epidural lipomatosis (LEL) is a condition characterized by excessive deposition of epidural fat in the spinal canal. Metabolic abnormalities may be associated with LEL, but few validated reports exist. Thus, we investigated the association between LEL and metabolic disorders in this study. METHODS: A total of 218 patients who had neurological symptoms due to neural compression in the lumbar spinal canal were examined by magnetic resonance imaging (MRI), abdominal computed tomography (CT) scans and blood tests...
May 2, 2018: European Spine Journal
https://www.readbyqxmd.com/read/29693236/benefits-of-bariatric-surgery-on-spinal-epidural-lipomatosis-case-report-and-literature-review
#4
REVIEW
J Valcarenghi, O Bath, H Boghal, M Ruelle, J Lambert
Spinal epidural lipomatosis is an abnormal accumulation of unencapsulated epidural fat causing compression of the neural elements. It can be divided into idiopathic and secondary. Secondary is often associated with chronic steroid use and endocrinopathies. Idiopathic has been associated with obesity. We report a 48-year-old man with obesity and a history of chronic back pain who developed idiopathic spinal epidural lipomatosis diagnosed by magnetic resonance imaging, which subsequently resolved completely after sleeve gastroplasty over a 6-month follow-up period...
April 24, 2018: European Journal of Orthopaedic Surgery & Traumatology: Orthopédie Traumatologie
https://www.readbyqxmd.com/read/29683947/encephalocraniocutaneous-lipomatosis
#5
Abhishek Bavle, Rikin Shah, Naina Gross, Theresa Gavula, Alejandro Ruiz-Elizalde, Klaas Wierenga, Rene McNall-Knapp
A 5-year-old boy presented with worsening headaches for 3 months. On examination, he was found to have a hairless fatty tissue nevus of the scalp (nevus psiloliparus), subcutaneous soft tissue masses on the right side of his face, neck, mandible and right buttock and epibulbar dermoid of the right eye (choristoma) (Figs. 1A, B). Magnetic resonance imaging revealed a large suprasellar mass, which was debulked and found to be a pilocytic astrocytoma. Testing was not performed for the BRAF/KIAA1549 fusion or BRAFV600E mutation...
April 20, 2018: Journal of Pediatric Hematology/oncology
https://www.readbyqxmd.com/read/29680582/madelung-s-disease-multiple-symmetric-lipomatosis-in-an-alcoholic-patient
#6
R Ríos León, L Crespo Pérez, I García de la Filia Molina
No abstract text is available yet for this article.
April 18, 2018: Revista de Gastroenterología de México
https://www.readbyqxmd.com/read/29664337/pancreatic-stiffness-quantified-with-mr-elastography-relationship-to-postoperative-pancreatic-fistula-after-pancreaticoenteric-anastomosis
#7
Yu Shi, Ying Liu, Feng Gao, Yanqing Liu, Shengzhen Tao, Yue Li, Kevin J Glaser, Richard L Ehman, Qiyong Guo
Purpose To describe the relationship between conventional magnetic resonance (MR) imaging parameters and MR elastography of the pancreas in association with pancreatic histologic features and occurrence of postoperative pancreatic fistula (POPF). Materials and Methods Patients who underwent preoperative MR imaging (MR elastography and diffusion-, T1-, and T2-weighted imaging) followed by pancreatectomy with pancreaticoenteric anastomosis were included. The relationships between preoperative MR imaging parameters, demographic data, and intraoperative factors with POPF risk were analyzed with logistic regression analyses...
April 17, 2018: Radiology
https://www.readbyqxmd.com/read/29595411/comparison-of-relative-and-absolute-values-of-magnetic-resonance-imaging-in-the-diagnosis-of-spinal-epidural-lipomatosis
#8
Yuxi Ge, Xiaohan Yang, Yaqian You, Yinghua Xuan, Gen Yan
Objective To describe spinal epidural lipomatosis (SEL) of the lumbar region and evaluate the relative versus absolute values of epidural fat (EF) to determine which is more appropriate when using magnetic resonance imaging (MRI). Design Comparative study. Setting Hospital. Participants Eight SEL patients and 40 healthy adults. Interventions MRI measurement of EF. Outcome Measures The MRI-based EF thickness, cutoff value, and coefficient of variation (CV) were calculated. Frequency distribution maps for the absolute EF value and the relative EF/DuS value were created...
March 29, 2018: Journal of Spinal Cord Medicine
https://www.readbyqxmd.com/read/29549527/in-vitro-efficacy-of-arq-092-an-allosteric-akt-inhibitor-on-primary-fibroblast-cells-derived-from-patients-with-pik3ca-related-overgrowth-spectrum-pros
#9
C Ranieri, S Di Tommaso, D C Loconte, V Grossi, P Sanese, R Bagnulo, F C Susca, G Forte, A Peserico, A De Luisi, A Bartuli, A Selicorni, D Melis, M Lerone, A D Praticò, G Abbadessa, Y Yu, B Schwartz, Martino Ruggieri, Cristiano Simone, Nicoletta Resta
Postzygotic mutations of the PIK3CA [phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha] gene constitutively activate the PI3K/AKT/mTOR pathway in PIK3CA-related overgrowth spectrum (PROS) patients, causing congenital mosaic tissue overgrowth that even multiple surgeries cannot solve. mTOR inhibitors are empirically tested and given for compassionate use in these patients. PROS patients could be ideal candidates for enrolment in trials with PI3K/AKT pathway inhibitors, considering the "clean" cellular setting in which a unique driver, a PIK3CA mutation, is present...
May 2018: Neurogenetics
https://www.readbyqxmd.com/read/29537156/lipomatosen
#10
Philipp Al Ghazal, Lisa-Lena Grönemeyer, Michael P Schön
Als Lipomatosen bezeichnet man gutartige, meist ohne eindeutige Auslöser auftretende Vermehrungen des Fettgewebes, oft mit typischem Verteilungsmuster. Im Gegensatz zu umschriebenen Lipomen entwickeln sie sich meist diffus-symmetrisch und sind nicht von einer fibrösen Pseudokapsel umgeben. Am häufigsten ist die benigne symmetrische Lipomatose (BSL; Launois-Bensaude-Syndrom), von der aufgrund des Verteilungsmusters des hyperplastischen Fettgewebes vier Typen unterschieden werden. Ätiologie und Pathogenese der Erkrankung sind noch weitgehend unbekannt, wobei manche Formen eine hereditäre Basis zu haben oder mit vermehrtem Alkoholkonsum assoziiert zu sein scheinen...
March 2018: Journal der Deutschen Dermatologischen Gesellschaft, Journal of the German Society of Dermatology: JDDG
https://www.readbyqxmd.com/read/29526030/superior-vena-cava-stenosis-due-to-lipomatosis-of-the-right-atrium
#11
Masashi Yokose, Hirotaka Sato, Hirohiko Akutsu, Yoshio Misawa
No abstract text is available yet for this article.
March 2018: Journal of Cardiac Surgery
https://www.readbyqxmd.com/read/29524979/bilateral-hydronephrosis-and-acute-kidney-injury-secondary-to-pelvis-lipomatosis
#12
Wesley Baas, Blake O'Connor, Ahmed El-Zawahry
A 57-year-old African American male presented with vague abdominal pain and bilateral flank pain. The patient was found to have bilateral hydronephrosis and significant renal function impairment secondary to pelvic lipomatosis. Pelvic lipomatosis represents a clinically-diagnosed unique cause of ureteral obstruction and subsequent renal impairment. We present a case report of newly diagnosed pelvic lipomatosis, the clinical and imaging characteristics for diagnosis, and its conservative management with serial ureteral stent exchanges...
February 2018: Canadian Journal of Urology
https://www.readbyqxmd.com/read/29522292/extensive-renal-sinus-lipomatosis-in-xanthogranulomatous-pyelonephritis-simulating-liposarcoma
#13
Sabrina de Mello Ando, Raquel Andrade Moreno, Públio Cesar Cavalcante Viana, Fernando Ide Yamauchi
Renal replacement lipomatosis is a condition characterized by varying degrees of renal parenchymal atrophy and perirenal fibrofatty proliferation secondary to chronic inflammation such as xanthogranulomatous pyelonephritis. In severe cases, imaging findings can be misdiagnosed as retroperitoneal liposarcoma.
March 9, 2018: International Braz J Urol: Official Journal of the Brazilian Society of Urology
https://www.readbyqxmd.com/read/29490659/clinical-and-imaging-characteristics-in-patients-undergoing-surgery-for-lumbar-epidural-lipomatosis
#14
Taketoshi Yasuda, Kayo Suzuki, Yoshiharu Kawaguchi, Shoji Seki, Hiroto Makino, Kenta Watanabe, Takeshi Hori, Tohru Yamagami, Masahiko Kanamori, Tomoatsu Kimura
BACKGROUND: Lumbar epidural lipomatosis (LEL) is characterized by abnormal accumulation of unencapsulated adipose tissue in the spinal epidural space. Such accumulation compresses the dural sac and nerve roots, and results in various neurological findings. However, the pathophysiology of LEL remains unclear. This study examined the associations between imaging and clinical findings in detail, and investigated the mechanisms underlying symptom onset by measuring intraoperative epidural pressures in LEL...
March 1, 2018: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/29441296/tuberous-sclerosis-complex-and-diffuse-lipomatosis-case-report-of-a-rare-association
#15
Ankit Mittal, Keshavamurthy Vinay, Dipankar De, Sanjeev Handa, Anindita Sinha
Lipomatosis is characterized by diffuse infiltration of adipocytes in a tissue. A young male patient presented for evaluation of unilateral limb swelling. On evaluation, he was found to have tuberous sclerosis complex with diffuse lipomatosis of the right leg. To the best of the authors' literature search, only two previous reports of association of tuberous sclerosis complex with diffuse lipomatosis were found. The molecular mechanisms behind the co-occurrence of these two entities have not been studied in detail...
January 2018: Indian Dermatology Online Journal
https://www.readbyqxmd.com/read/29431910/lipomatoses
#16
Philipp Al Ghazal, Lisa-Lena Grönemeyer, Michael P Schön
Lipomatoses are benign proliferations of adipose tissue, often with typical distribution patterns, which usually occur without clear causes. In contrast to circumscribed lipomas, they develop diffusely and symmetrically and are not surrounded by a fibrous pseudocapsule. The most common form is benign symmetric lipomatosis (BSL; Launois-Bensaude syndrome), of which four types are distinguished based on the distribution pattern of hyperplastic adipose tissue. The etiology and pathogenesis of the disease are still largely unknown, although some forms appear to have a hereditary basis or to be associated with increased alcohol consumption...
March 2018: Journal der Deutschen Dermatologischen Gesellschaft, Journal of the German Society of Dermatology: JDDG
https://www.readbyqxmd.com/read/29403255/unusual-cause-of-lumbar-canal-stenosis-in-8-th-decade-of-life-spinal-epidural-lipomatosis
#17
Manoj Phalak, Sukanta Das, Manmohan Singh, Bhawani Shanker Sharma
Spinal Epidural lipomatosis (SEL) is an uncommon condition, usually presents in young and middle aged patients, with male preponderance. Idiopathic SEL is rare, particularly in 8th decade of life. SEL should also be considered as a differential diagnosis in approach of elderly patient presenting with lumbar canal stenosis. Such a case of 77 year old man is presented here.
October 2017: Journal of Craniovertebral Junction and Spine
https://www.readbyqxmd.com/read/29290322/-nevus-lipomatosus-cutaneous-superficialis-report-of-four-cases-including-an-unusual-presentation-associated-with-massive-lipomas-and-diffuse-lipomatosis
#18
Mariana Medell-Gago, Tamara Guerra-Guerra, Orlando González-Pérez, Leonardo Concepción-Quiñones
Nevus lipomatosus cutaneus superficialis is a rare, hamartomatous disorder, characterized by the presence of ectopic mature adipose tissue within the superficial dermis. Lesions occur within the first three decades of life. We report four new cases, including a patient with the most extensive affectation reported to date, which was associated with massive lipomas in the subcutaneous cell tissue and diffuse lipomatosis. To our knowledge, it is the first report of this disorder in Cuba.
January 2018: Revista Española de Patología
https://www.readbyqxmd.com/read/29285599/computed-tomography-and-magnetic-resonance-imaging-of-peripelvic-and-periureteric-pathologies
#19
REVIEW
Ekim Gumeler, Mehmet Ruhi Onur, Ali Devrim Karaosmanoglu, Mustafa Ozmen, Deniz Akata, Musturay Karcaaltincaba
Peripelvic and periureteric areas are frequently overlooked in the imaging evaluations of the urinary system on computed tomography and magnetic resonance imaging. Several neoplastic and non-neoplastic disorders and diseases including lipomatosis, angiomyolipoma and angiolipomatous proliferation, vascular lesions, lymphangiomatosis, Rosai-Dorfman disease, Erdheim-Chester disease, extramedullary hematopoiesis, IgG4-related disease, lymphoma, mesenchymal tumors, trauma, and Antopol-Goldman lesion may involve these areas...
December 28, 2017: Abdominal Radiology
https://www.readbyqxmd.com/read/29273822/management-of-idiopathic-spinal-epidural-lipomatosis-a-case-report-and-review-of-the-literature
#20
Steven T Papastefan, Abhiraj D Bhimani, Steven Denyer, Sajeel R Khan, Darian R Esfahani, Demetrios C Nikas, Ankit I Mehta
BACKGROUND: Spinal epidural lipomatosis (SEL) is a rare pathologic growth of histologically normal unencapsulated adipose tissue in the epidural space. Although rare, SEL can compress the spinal cord or nerve roots causing myelopathy or radiculopathy. While SEL has been associated with long-term exposure to endogenous or exogenous steroids and obesity, idiopathic forms of SEL are much rarer. CASE REPORT: In this report, we present the first case of SEL isolated to the cervical region compressing the spinal cord in a healthy, non-obese, preadolescent patient...
April 2018: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
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