keyword
MENU ▼
Read by QxMD icon Read
search

Multiple symmetric lipomatosis

keyword
https://www.readbyqxmd.com/read/27862896/homozygous-lipe-mutation-in-siblings-with-multiple-symmetric-lipomatosis-partial-lipodystrophy-and-myopathy
#1
Sagit Zolotov, Chao Xing, Riad Mahamid, Adel Shalata, Mohammed Sheikh-Ahmad, Abhimanyu Garg
Despite considerable progress in identifying causal genes for lipodystrophy syndromes, the molecular basis of some peculiar adipose tissue disorders remains obscure. In an Israeli-Arab pedigree with a novel autosomal recessive, multiple symmetric lipomatosis (MSL), partial lipodystrophy and myopathy, we conducted exome sequencing of two affected siblings to identify the disease-causing mutation. The 41-year-old female proband and her 36-year-old brother reported marked accumulation of subcutaneous fat in the face, neck, axillae, and trunk but loss of subcutaneous fat from the lower extremities and progressive distal symmetric myopathy during adulthood...
November 11, 2016: American Journal of Medical Genetics. Part A
https://www.readbyqxmd.com/read/27427539/a-case-of-symmetrical-lipomatosis-of-the-tongue-presenting-as-macroglossia
#2
Maria Giulia Cristofaro, Walter Colangeli, Umberto Riccelli, Mario Giudice
UNLABELLED: Lipomas are the most common benign soft tissue mesenchymal tumours composed of mature adipose tissue. They are uncommon in the oral and maxillofacial regions, with 15-20 % of cases involving the head and neck region and less than 5% of all benign oral lesions. Multiple symmetric lipomatosis is rare and characterized by diffuse growth and nonencapsulated lipomas. It is usually found in the posterior neck and upper trunk and they are relatively infrequent on the oral and maxillofacial regions like Madelung disease...
2016: Annali Italiani di Chirurgia
https://www.readbyqxmd.com/read/27413566/symmetric-lipomatosis-arising-in-the-tongue-presenting-as-macroglossia-and-articulatory-disorder
#3
Masanori Kudoh, Ken Omura, Arata Satsukawa, Koshi Matsumoto, Takahide Taguchi, Hiroyuki Harada, Yoshimasa Ishii
Symmetric lipomatosis is definitively characterized by symmetric, tumorous lipomatous proliferation of adipose tissue that often develops in the head and neck, shoulders, and upper trunk. However, in the oral region, symmetric lipomatosis of the tongue (SLT) is an extremely rare condition related to generalized lipidosis that is often caused by chronic alcoholism. It is characterized by multiple symmetric lipomatous nodules and diffuse bilateral swelling located within the tongue. We report an extremely rare case of SLT arising in an 80-year-old man with a long history of alcoholic liver cirrhosis...
2016: Case Reports in Otolaryngology
https://www.readbyqxmd.com/read/27225269/adipose-derived-stromal-cells-from-lipomas-isolation-characterisation-and-review-of-the-literature
#4
Mathias Tremp, Nadia Menzi, Laurent Tchang, Pietro G di Summa, Dirk J Schaefer, Daniel F Kalbermatten
OBJECTIVE: The aim of this study was to characterize adipose-derived stromal cells (ADSCs) from patients diagnosed with multiple symmetric lipomatosis (MSL) in order to obtain potentially new insights into the pathophysiology, pathogenesis and treatment of this disease. METHODS: Cells from the stromal vascular fraction were analysed by the colony-forming efficiency assay and flow cytometry using standard markers. Moreover, the power of adipogenic plasticity was evaluated...
2016: Pathobiology: Journal of Immunopathology, Molecular and Cellular Biology
https://www.readbyqxmd.com/read/27018673/transcription-profile-in-sporadic-multiple-symmetric-lipomatosis-reveals-differential-expression-at-the-level-of-adipose-tissue-derived-stem-cells
#5
Lukas Prantl, Julia Schreml, Sebastian Gehmert, Silvan Klein, Xiaowen Bai, Katharina Zeitler, Stephan Schreml, Eckhard Alt, Sanga Gehmert, Oliver Felthaus
BACKGROUND: The cause of the rare fat distribution disorder multiple symmetric lipomatosis is unknown. Independent reports suggest a higher proliferative activity, hormone resistance, and involvement of mitochondrial function in the disease. METHODS: The authors performed morphologic comparison of affected and unaffected tissues in five unrelated patients and generated adipose-derived stem cell cultures from the tissue samples and characterized them as a possible cellular model of multiple symmetric lipomatosis evolution...
April 2016: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/26256662/multiple-symmetric-lipomatosis-presenting-with-bilateral-brachial-plexopathy
#6
Kee Hong Park, Yoon Ho Hong, Seok Jin Choi, Jung Joon Sung, Kwang Woo Lee
No abstract text is available yet for this article.
October 2015: Journal of Clinical Neurology
https://www.readbyqxmd.com/read/26228680/symmetrical-lipomatosis-of-the-tongue-case-report-and-literature-review
#7
Munehiro Azuma, Makoto Adachi, Masayuki Motohashi, Yasunori Muramatsu
Multiple symmetric lipomatosis is rare and characterized by diffuse growth and nonencapsulated lipomas. It is usually found in the posterior neck and upper trunk, and the entity is known as "benign symmetric lipomatosis," "Madelung disease," and "Launois-Bensaude syndrome." Symmetric lipomatosis of the tongue was first described by Desmond and is an extremely rare condition. A 74-year-old man complained of painless tongue swelling and difficulty speaking. Clinical findings revealed no tumor masses on the trunk, limbs, or head and neck region...
July 2015: Journal of Clinical Lipidology
https://www.readbyqxmd.com/read/26180731/extracorporeal-acoustic-wave-therapy-and-multiple-symmetric-lipomatosis
#8
Carlotta Scarpa, Vincenzo Vindigni, Franco Bassetto
Acoustic waves are mechanical waves recently used to activate tissue metabolism by exploiting the cell permeabilization caused by their passage. We report a case of a retroauricular lipoma in a 44-year-old woman affected by multiple symmetric lipomatosis and treated with extracorporeal acoustic wave therapy. The adipose thickness of the lipoma was reduced from 35.8 to 21 mm, with increased softness at palpatory examination.
June 2015: Plastic and Reconstructive Surgery. Global Open
https://www.readbyqxmd.com/read/26148871/mir-125a-3p-and-mir-483-5p-promote-adipogenesis-via-suppressing-the-rhoa-rock1-erk1-2-pathway-in-multiple-symmetric-lipomatosis
#9
Ke Chen, Honghui He, Yanhong Xie, Liling Zhao, Shaoli Zhao, Xinxing Wan, Wenjun Yang, Zhaohui Mo
Multiple symmetric lipomatosis (MSL) is a rare disease characterized by symmetric and abnormal distribution of subcutaneous adipose tissue (SAT); however, the etiology is largely unknown. We report here that miR-125a-3p and miR-483-5p are upregulated in the SAT of MSL patients, promoting adipogenesis through suppressing the RhoA/ROCK1/ERK1/2 pathway. TaqMan microRNA (miR) array analysis revealed that 18 miRs were upregulated in the SAT of MSL patients. Transfection of human adipose-derived mesenchymal stem cells (hADSCs) with the individual agomirs of these 18 miRs showed that miR-125a-3p and miR-483-5p significantly promoted adipogenesis...
July 7, 2015: Scientific Reports
https://www.readbyqxmd.com/read/26085578/homozygous-mutations-in-mfn2-cause-multiple-symmetric-lipomatosis-associated-with-neuropathy
#10
Sarah L Sawyer, Andy Cheuk-Him Ng, A Micheil Innes, Justin D Wagner, David A Dyment, Martine Tetreault, Jacek Majewski, Kym M Boycott, Robert A Screaton, Garth Nicholson
Multiple symmetric lipomatosis (MSL) is a mitochondrial disorder with impaired brown fat metabolism that has been associated with MERRF mutations in some, but not all, patients. We studied a sibling pair and an unrelated indiviadual who presented with MSL and neuropathy to determine the genetic etiology of this disorder in patients who did not carry the MSL-associated MERRF mutation. Whole-exome sequencing was performed on the siblings, and a rare, shared homozygous mutation in MFN2 (c.2119C>T: p.R707W) was identified...
September 15, 2015: Human Molecular Genetics
https://www.readbyqxmd.com/read/25945255/a-case-of-madelung-s-disease-accompanied-by-klinefelter-s-syndrome
#11
Aysenur Ozderya, Sule Temizkan, Kadriye Aydin Tezcan, Feyza Yener Ozturk, Yuksel Altuntas
UNLABELLED: Madelung's disease is a rare fat metabolism disorder characterised by benign multiple symmetric, encapsulated lipomatosis. The exact cause of the disease is unknown; it may be associated with chronic alcoholism and mutations in mitochondrial DNA (A8344G), but there have been cases without these factors reported in the literature. A 29-year-old man with a 6-year history of diabetes mellitus was admitted to our hospital for poorly regulated diabetes and decreased libido. He was not an alcohol consumer...
2015: Endocrinology, Diabetes & Metabolism Case Reports
https://www.readbyqxmd.com/read/25860506/syndromic-lipomatosis-of-the-head-and-neck-a-review-of-the-literature
#12
REVIEW
Kashyap Komarraju Tadisina, Karolina S Mlynek, Lyahn K Hwang, Hooman Riazi, Francis A Papay, James E Zins
INTRODUCTION: Patients with syndromic causes of lipomatosis of the head and neck, although rare, often present late in the course of the disease in a myriad of ways, including concomitant airway obstruction, severe functional limitations, and/or significant cosmetic defects. The goal of this report was to review the literature and present a concise overview of the major syndromes causing lipomatosis of the head and neck. METHODS: A literature search was performed to gather information on syndromic lipomatosis of the head and neck region...
June 2015: Aesthetic Plastic Surgery
https://www.readbyqxmd.com/read/25826795/a-middle-aged-man-with-increasing-body-fat
#13
J K Y Lam, K S L Lam, W S Chow, K C B Tan
A 51-year-old man was referred for evaluation of gradual increase in body fat over bilateral arms, chest and abdomen for 6 months. He was a non-smoker and he drank at least four bottles of beer daily since the age of 18. There was no significant past medical history or any family history of obesity or endocrine diseases. Physical examination showed localized large bulk of fat over the neck, both arms and mammary regions, abdomen, and back (Figs  and ). The lower limbs and buttock were relatively spared...
August 2014: Clinical Obesity
https://www.readbyqxmd.com/read/25770761/multiple-symmetric-lipomatosis-a-rare-disease-and-its-possible-links-to-brown-adipose-tissue
#14
REVIEW
G Enzi, L Busetto, G Sergi, A Coin, E M Inelmen, V Vindigni, F Bassetto, S Cinti
AIM: Aim of this study is an updated review of our case series (72 patients) as well as available literature on the Multiple Symmetric Lipomatosis (MSL), a rare disease primarily involving adipose tissue, characterized by the presence of not encapsulated fat masses, symmetrically disposed at characteristic body sites (neck, trunk, proximal parts of upper and lower limbs). DATA SYNTHESIS: The disease is more frequent in males, associated to an elevated chronic alcohol consumption, mainly in form of red wine...
April 2015: Nutrition, Metabolism, and Cardiovascular Diseases: NMCD
https://www.readbyqxmd.com/read/25548590/multiple-symmetric-lipomatosis-madelung-s-disease-presenting-as-bilateral-huge-gynecomastia
#15
Jae Hoon Jang, Anbok Lee, Sang-Ah Han, Jung-Kyu Ryu, Jeong-Yoon Song
Multiple symmetric lipomatosis (MSL), or Madelung's disease, is a rare disease of unknown etiology. It is characterized by the presence of loose adipose tissue deposits localized in the cervical region and upper body. MSL presenting as bilateral huge gynecomastia is an extremely rare phenomenon. The present report describes a case of MSL in a 66-year-old man. The patients presented with bilateral breast bulging. He had a history of cigarette and alcohol use. His condition was treated with a bilateral nipple-sparing mastectomy...
December 2014: Journal of Breast Cancer
https://www.readbyqxmd.com/read/25424205/michelin-tire-baby-syndrome-a-review-of-the-literature-and-a-proposal-for-diagnostic-criteria-with-adoption-of-the-name-circumferential-skin-folds-syndrome
#16
REVIEW
Ilene L Rothman
The term Michelin tire baby (MTB), named for the cartoon mascot of the Michelin Tire Company, has been used to describe babies with multiple symmetric circumferential rings of folded skin. In those reported with this phenotype who had skin biopsies, pathology has shown nevus lipomatosis, smooth muscle hamartoma, degenerative collagen, and scarring. Others did not undergo biopsy or had normal skin. Many individuals with the MTB phenotype have had a variety of other congenital anomalies. I review the literature on MTB and the history of the designation Michelin tire baby Syndrome (MTBS)...
November 2014: Pediatric Dermatology
https://www.readbyqxmd.com/read/25393046/power-assisted-liposuction-pal-of-multiple-symmetric-lipomatosis-msl-a-longitudinal-study
#17
Mathias Tremp, Reto Wettstein, Laurent A Tchang, Dirk J Schaefer, Ulrich M Rieger, Daniel F Kalbermatten
BACKGROUND: Multiple symmetric lipomatosis (MSL) is a rare condition leading to grotesque disfigurement. Complete removal is almost impossible and recurrences inevitable. The objective of this study was to evaluate powered-assisted liposuction (PAL) for the treatment of MSL. METHODS: Magnetic resonance imaging (MRI) was performed before and after surgery for quality assessment. To exclude malignancy incisional biopsies were taken before surgery. Outcome measures included aspiration volumes, duration of surgery, early morbidity, recurrence rates, and overall patient satisfaction...
January 2015: Surgery for Obesity and related Diseases: Official Journal of the American Society for Bariatric Surgery
https://www.readbyqxmd.com/read/25316771/intrapulmonary-lipomatosis
#18
Chao-Yu Liu, Yu-Chao Yu, Chih-Cheng Hsieh, Yeh-Han Wang, Teh-Ying Chou
No abstract text is available yet for this article.
November 2014: Thorax
https://www.readbyqxmd.com/read/25114492/case-report-of-comorbid-alcohol-induced-psychotic-disorder-and-madelung-s-disease
#19
Zhenxiao Sun, Huanjun Li
Madelung's disease, also known as benign symmetric lipomatosis (BSL), multiple symmetric lipomatosis (MSL), fatty neck syndrome or Launois-Bensaude syndrome, is a rare disease characterized by the presence of multiple, symmetric, loose adipose tissues distributed around the neck, occipitalis, shoulder, back or chest. The fat masses are non-encapsulated and therefore can move freely between adjacent areas. This disease is most commonly seen among middle-aged Caucasian men of Mediterranean origins; it is rarely reported in Asia...
June 2014: Shanghai Archives of Psychiatry
https://www.readbyqxmd.com/read/25065051/bilateral-large-palpable-cervical-masses-not-always-a-malignant-or-infectious-process
#20
Luis A Figueroa-Jiménez, Mónica Santiago-Casiano, Emmanuel González-Irizarry, Amy González-Marquez, William Cáceres-Perkins, Mildred Padilla-Ferrer, Anarda González, Verónica Santiago-Casiano
Madelung's disease is an extremely rare disorder of unknown etiology characterized by multiple, non-encapsulated, infiltrative lipomas located symmetrically on the trunk, neck, and proximal parts of the limbs. Approximately 200 patients have been reported in the medical literature. In this case report we present an extremely unusual case of multiple symmetric lipomatosis compatible with Madelung's disease.
2014: Boletín de la Asociación Médica de Puerto Rico
keyword
keyword
62485
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"