keyword
https://read.qxmd.com/read/37981055/perinatal-morphine-but-not-buprenorphine-affects-gestational-and-offspring-neurobehavioral-outcomes-in-mice
#21
JOURNAL ARTICLE
Brittany L Smith, Ally Hassler, Kelsey R Lloyd, Teresa M Reyes
Within the national opioid epidemic, there has been an increase in the number of infants exposed to opioids in utero. Additionally, opioid agonist medications are the standard of care for women with opioid use disorder during pregnancy. Buprenorphine (BUP), a partial µ -opioid receptor agonist, has been successful in improving gestational and neonatal outcomes. However, in utero exposure has been linked to childhood cognitive and behavioral problems. Therefore, we sought to compare offspring cognitive and behavioral outcomes after prenatal exposure to a clinically relevant low dose of BUP compared to morphine (MO), a full µ -opioid receptor agonist and immediate metabolite of heroin...
December 2023: Neurotoxicology
https://read.qxmd.com/read/37974195/identifying-the-data-elements-and-functionalities-of-clinical-decision-support-systems-to-administer-medication-for-neonates-and-pediatrics-a-systematic-literature-review
#22
REVIEW
Somaye Norouzi, Zahra Galavi, Leila Ahmadian
BACKGROUND: Patient safety is a central healthcare policy worldwide. Adverse drug events (ADE) are among the main threats to patient safety. Children are at a higher risk of ADE in each stage of medication management process. ADE rate is high in the administration stage, as the final stage of preventing medication errors in pediatrics and neonates. The most effective way to reduce ADE rate is using medication administration clinical decision support systems (MACDSSs). The present study reviewed the literature on MACDSS for neonates and pediatrics...
November 16, 2023: BMC Medical Informatics and Decision Making
https://read.qxmd.com/read/37971685/implementation-of-a-national-system-for-best-practice-delivery-of-paediatric-infusions
#23
JOURNAL ARTICLE
Moninne M Howlett, Sharon Sutton, Eimear L McGrath, Cormac V Breatnach
BACKGROUND: Standard concentration infusions and 'smart-pumps' are recognised as best practice in the paediatric setting. Implementation rates in European hospitals remain low. Children's Health Ireland (CHI) developed a paediatric 'smart-pump' drug library using standardised concentrations. At time of development, other Irish hospitals continued to use traditional pumps and weight-based paediatric infusions. AIM: To expand best paediatric infusion practices by nationalising use of the CHI drug library...
November 16, 2023: International Journal of Clinical Pharmacy
https://read.qxmd.com/read/37941064/new-challenges-in-management-of-phenylketonuria-in-pregnancy-a-case-report
#24
JOURNAL ARTICLE
Beatriz Ugalde-Abiega, Sinziana Stanescu, Amaya Belanger, Mercedes Martinez-Pardo, Francisco Arrieta
BACKGROUND: Phenylketonuria (PKU) is an autosomal recessive disease that belongs to a group of disorders resulting from inborn errors of protein metabolism. It was the first disease included in neonatal screening. Neonatal screening has allowed an early diagnosis and treatment of the disease. As a result, an increasing number of women diagnosed with phenylketonuria have reached the reproductive phase of life in good health, and management of pregnancy in women with PKU is becoming more frequent...
November 9, 2023: Journal of Medical Case Reports
https://read.qxmd.com/read/37922224/adverse-events-in-pediatric-inpatients-the-japan-adverse-event-study
#25
JOURNAL ARTICLE
Mio Sakuma, Yoshinori Ohta, Jiro Takeuchi, Yuki Yuza, Hiroyuki Ida, David W Bates, Takeshi Morimoto
OBJECTIVES: Adverse events (AEs) represent an important cause of morbidity and mortality for pediatric inpatients; however, reports on their epidemiology in pediatrics, especially outside Western countries, are scarce. We investigated the incidence and nature of AEs in pediatric inpatients in Japan. METHODS: Trained pediatrician and pediatric nurses reviewed all medical documents of 1126 pediatric inpatients in 2 tertiary care teaching hospitals in Japan, and potential incidents were collected with patients' characteristics...
November 6, 2023: Journal of Patient Safety
https://read.qxmd.com/read/37918217/developing-a-length-of-stay-prediction-model-for-newborns-achieving-better-accuracy-with-greater-usability
#26
JOURNAL ARTICLE
Tzviel Frostig, Yoav Benjamini, Orli Kehat, Ahuva Weiss-Meilik, Dror Mandel, Ben Peleg, Zipora Strauss, Alexis Mitelpunkt
BACKGROUND: One in ten newborn children is born prematurely. The elongated length of stay (LOS) of these children in the Neonatal Intensive Care Unit (NICU) has important implications on hospital occupancy figures, healthcare and management costs, as well as the psychology of parents. In order to allow accurate planning and resource allocation, this study aims to create a generalizable and robust model to predict the NICU LOS of preterm newborns. METHODS: Data were collected from a large tertiary center NICU between 2011 and 2018 and relates to 5,362 newborns...
October 21, 2023: International Journal of Medical Informatics
https://read.qxmd.com/read/37889401/intravenous-medication-administration-safety-with-smart-infusion-pumps-in-the-neonatal-intensive-care-unit-an-observational-study
#27
JOURNAL ARTICLE
Kumiko O Schnock, Sara E Rostas, Catherine S Yoon, Stuart Lipsitz, David W Bates, Patricia C Dykes
INTRODUCTION: Infants in the neonatal intensive care unit (NICU) are among the most vulnerable patient populations and medication errors are a significant source of risk and harm to neonates. Smart infusion pumps have been implemented to support the safe medication administration process; however, the effect of using smart infusion pumps on medication safety in the NICU is still unclear. METHODS: We conducted an observational study with a prospective point-prevalence approach to investigate intravenous (IV) medication administration errors in the NICU at one academic medical center in the USA...
October 27, 2023: Drug Safety: An International Journal of Medical Toxicology and Drug Experience
https://read.qxmd.com/read/37873850/a-review-of-disparities-and-unmet-newborn-screening-needs-over-33-years-in-a-cohort-of-mexican-patients-with-inborn-errors-of-intermediary-metabolism
#28
JOURNAL ARTICLE
Isabel Ibarra-González, Cynthia Fernández-Lainez, Marcela Vela-Amieva, Sara Guillén-López, Leticia Belmont-Martínez, Lizbeth López-Mejía, Rosa Itzel Carrillo-Nieto, Nidia Alejandra Guillén-Zaragoza
Advances in an early diagnosis by expanded newborn screening (NBS) have been achieved mainly in developed countries, while populations of middle- and low-income countries have poor access, leading to disparities. Expanded NBS in Mexico is not mandatory. Herein, we present an overview of the differences and unmet NBS needs of a group of Mexican patients with inborn errors of intermediary metabolism (IEiM), emphasizing the odyssey experienced to reach a diagnosis. We conducted a retrospective observational study of a historical cohort of patients with IEiM from a national reference center...
October 19, 2023: International Journal of Neonatal Screening
https://read.qxmd.com/read/37863984/fundamentals-of-designing-high-quality-surveys-revisiting-neonatal-perinatal-medicine-survey-applications
#29
REVIEW
Kadriye O Lewis, Howard W Kilbride, Carl Bose, David J Burchfield
Surveys in neonatal perinatal medicine are practical instruments for gathering information about medical practices, and outcomes related to the care of newborns and infants. This includes research for identifying needs, assessing requirements, analyzing the effects of change, creating policies, and developing curriculum initiatives. Surveys also provide useful data for enhancing the provision of healthcare services, assessing medical specialties, and evaluating training programs. However, creating a high-quality survey can be difficult for many practitioners, particularly when deciding how to formulate the right questions, whether to utilize various types of questions and how best to arrange or format the survey tool for effective responses...
October 20, 2023: Journal of Perinatology: Official Journal of the California Perinatal Association
https://read.qxmd.com/read/37851969/accuracy-of-estimated-fetal-weight-by-ultrasound-versus-leopold-maneuver
#30
JOURNAL ARTICLE
Alicia Lunardhi, Kimberly Huynh, Derek Lee, Trevor A Pickering, Kristina D Galyon, Hindi E Stohl
Estimated fetal weight (EFW) is frequently used for clinical decision-making in obstetrics. The goals of this study were to determine the accuracy of EFW assessments by Leopold and ultrasound and to investigate any associations with maternal characteristics. Postgraduate years 1 and 2 obstetrics and gynecology resident physicians from Harbor-UCLA Medical Center from 2014 to 2020 performed EFW assessments on 10 preterm (<37 weeks' gestational age) fetuses by ultrasound biometry and 10 full-term (≥37 weeks' gestational age) fetuses by ultrasound biometry and Leopold maneuver...
October 18, 2023: Ultrasound Quarterly
https://read.qxmd.com/read/37822418/the-first-reported-case-of-a-child-with-two-different-rare-metabolic-disorders-very-long-chain-acyl-coa-dehydrogenase-deficiency-and-encephalomyopathic-mitochondrial-dna-depletion-syndrome-13
#31
Maha Alotaibi, Amal Alqasmi, Faisal Albassam, Turki Alkahtani, Muath Alqahtany, Mohammed Alkhaldi
One of the most common inborn errors in fatty acid β oxidation (FAO) is a very long-chain acyl-coenzyme A dehydrogenase (VLCAD) deficiency. It is autosomal recessive. The enzyme used in the first phase of FAO is VLCAD. The enzyme is responsible for β oxidation spiral pathway's initial step, the dehydrogenation process of long-chain fatty acyl-CoA. The phenotypes include hypoglycemia, hepatomegaly, cardiomyopathy, and occasionally abrupt mortality. Most VLCAD deficiencies in newborns are now detected during the neonatal period due to the development of newborn screening programs...
December 2023: Global medical genetics
https://read.qxmd.com/read/37818200/handoff-tool-improves-transitions-from-the-operating-room-to-the-neonatal-intensive-care-unit
#32
JOURNAL ARTICLE
Julie B Gallois, Jessica A Zagory, Brian Barkemeyer, Michelle Knecht, Lauren Richard, Kathleen Vincent, David Sciacca, Crystal Maise-Dykes, Christy Mumphrey
INTRODUCTION: Standardized handoffs reduce medical errors and prevent adverse events or near misses. This article describes a quality improvement initiative implementing a unique standardized handoff tool and process to transition from the operating room to the neonatal intensive care unit (NICU) at a level-four regional center with many inpatients requiring surgical intervention. Before this project, there was no standardized handoff tool or process for postsurgical transitions. The primary aim was to achieve 80% compliance with completing a structured postoperative OR to NICU handoff tool within 12 months of implementation...
2023: Pediatric Quality & Safety
https://read.qxmd.com/read/37786341/incidents-relating-to-paediatric-regional-anaesthesia-in-the-first-8000-cases-reported-to-webairs
#33
JOURNAL ARTICLE
Manisha M Mistry, Yasmin Endlich
Regional anaesthesia is an essential tool in the armamentarium for paediatric anaesthesia. While largely safe and effective, a range of serious yet preventable adverse events can occur. Incidence and risk factors have been described, but few detailed case series exist relating to paediatric regional anaesthesia. Across Australia and New Zealand, a web-based anaesthesia incident reporting system enables voluntary reporting of detailed anaesthesia-related events in adults and children. From this database, all reports involving paediatric regional anaesthesia (age less than 17 years) were retrieved...
November 2023: Anaesthesia and Intensive Care
https://read.qxmd.com/read/37737092/analysis-of-anaesthesia-incidents-during-caesarean-section-reported-to-webairs-between-2009-and-2022
#34
JOURNAL ARTICLE
Victoria A Eley, Martin D Culwick, Alicia T Dennis
Anaesthesia for caesarean section occurs commonly and places specific demands on anaesthetists. We analysed 469 narratives concerning anaesthesia for caesarean section, entered by Australian and New Zealand anaesthetists into the webAIRS incident reporting system between 2009 and 2022. As expected, compared with the remaining 8978 database entries, the 469 incidents were more likely to be emergency cases (relative risk (RR) 1.95), more likely to occur between 18:00 and 22:00 hours (RR 1.81) and between 22:00 and 07:59 hours (RR 4...
November 2023: Anaesthesia and Intensive Care
https://read.qxmd.com/read/37718874/accidental-lipid-overdose-in-a-preterm-infant-a-case-report
#35
JOURNAL ARTICLE
M S Ryan, J McIntyre, L D Bramwell, S Ojha
BACKGROUND: Intravenous lipid emulsions (ILEs) provide essential fatty acids during parenteral nutrition (PN). Serious adverse events including death can occur from overdose. We report an accidental overdose in a preterm infant. METHOD: On Day 2 of life, a 29-week gestational age (GA) twin was accidentally given 47.5 mL of Intralipid20% (≈3x daily amount) in 50-minutes. RESULTS: No apparent clinical deterioration occurred, although blood samples were lipemic...
September 14, 2023: Journal of Neonatal-perinatal Medicine
https://read.qxmd.com/read/37701323/interstitial-lung-disease-and-pancreatic-exocrine-insufficiency-in-cadds-phenotypic-expansion-and-literature-review
#36
Oliver Heath, Dinusha Pandithan, James Pitt, Elena Savva, Laura Raiti, Jenny Bracken, Moya Vandeleur, Martin B Delatycki, Joy Yaplito-Lee, Winita Hardikar, Rebecca Halligan
Contiguous ABCD1 / DXS1357E deletion syndrome (CADDS) is a rare deletion syndrome involving two contiguous genes on Xq28, ABCD1 and BCAP31 (formerly known as DXS1357E ). Only nine individuals with this diagnosis have been reported in the medical literature to date. Intragenic loss-of-function variants in BCAP31 cause the deafness, dystonia, and cerebral hypomyelination syndrome (DDCH). Isolated pathogenic intragenic variants in ABCD1 are associated with the most common peroxisomal disorder, X-linked adrenoleukodystrophy (X-ALD), a single transporter deficiency, which in its more severe cerebral form is characterised by childhood-onset neurodegeneration and high levels of very-long-chain fatty acids (VLCFA)...
September 2023: JIMD Reports
https://read.qxmd.com/read/37688338/amino-acid-ratio-combinations-as-biomarkers-for-discriminating-patients-with-pyruvate-dehydrogenase-complex-deficiency-from-other-inborn-errors-of-metabolism
#37
JOURNAL ARTICLE
Anisha Verma, April N Lehman, Hatice Gokcan, Lorna Cropcho, Danielle Black, Steven F Dobrowolski, Jerry Vockley, Jirair K Bedoyan
BACKGROUND: Pyruvate dehydrogenase complex deficiency (PDCD) is a mitochondrial neurometabolic disorder of energy deficit, with incidence of about 1 in 42,000 live births annually in the USA. The median and mean ages of diagnosis of PDCD are about 12 and 31 months, respectively. PDCD is a major cause of primary lactic acidosis with concomitant elevation in blood alanine (Ala) and proline (Pro) concentrations depending on phenotypic severity. Alanine/Leucine (Ala/Leu) ≥4...
September 8, 2023: Molecular Genetics & Genomic Medicine
https://read.qxmd.com/read/37655372/white-coat-hypertension-in-pregnant-women-risk-factors-pregnancy-outcomes-and-biomarkers
#38
JOURNAL ARTICLE
Vasilii S Chulkov, Ekaterina Nikolenko, Vladislav Chulkov, Anastasia Podzolko
Hypertensive disorders of pregnancy are a worldwide health problem for women. They cause complications in up to 10% of pregnancies and are associated with increased maternal and neonatal morbidity and mortality. Traditional blood pressure measurement in clinical practice is the most commonly used procedure for diagnosing and monitoring hypertension treatment, but it is prone to significant inaccuracies caused, on the one hand, by the inherent variability of blood pressure and, on the other, by errors arising from measurement technique and conditions...
August 31, 2023: Folia Medica
https://read.qxmd.com/read/37645440/impact-of-clinical-pharmacist-led-intervention-for-drug-related-problems-in-neonatal-intensive-care-unit-a-randomized-controlled-trial
#39
JOURNAL ARTICLE
Nadir Yalçın, Merve Kaşıkcı, Hasan Tolga Çelik, Karel Allegaert, Kutay Demirkan, Şule Yiğit
Introduction: Drug-related problems (DRPs) incidence is higher in neonatal intensive care units (NICUs), compared to other pediatric wards due to aspects like off-label medications, pharmacokinetic/dynamic variability, or organ dysfunction/immaturity. This study aimed to determine whether and to what extent a clinical pharmacist intervention improves medication safety and prevents DRPs [medication errors (MEs), adverse drug reactions (ADRs), drug-drug interactions (DDIs)]. Methods: A prospective, randomized, double blind, controlled study in NICU-admitted neonates was conducted...
2023: Frontiers in Pharmacology
https://read.qxmd.com/read/37640658/safe-handoff-practices-and-improvement-of-communication-in-different-paediatric-settings
#40
JOURNAL ARTICLE
Pedro J Alcalá Minagorre, Araceli Domingo Garau, María José Salmerón Fernández, Cristina Casado Reina, Pilar Díaz Pernas, Ángel Antonio Hernández Borges, Belén Rodríguez Marrodán
Inadequate information management, especially during patient handoff, contributes to a large part of health care-related adverse events. The Committee for Quality of Care and Patient Safety of the Asociación Española de Pediatría has developed this document to provide an overview of handover practices in different paediatric care settings (emergency, inpatient, intensive care, neonatal and primary care). It describes resources to achieve safe and effective communication in all these settings, such as standardised handoff tools...
August 26, 2023: Anales de pediatría
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