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https://www.readbyqxmd.com/read/28351042/intracellular-edema
#1
Raja Narayanan, Baruch D Kuppermann
The macula is predisposed to edema in various retinal conditions, even when the insult is remote from the macula. The various factors that may predispose the macula to edema include high metabolic activity, radial arrangement of the Henle's layer, lack of inner layers at the fovea, and lack of blood supply at the fovea. The edema is most pronounced in the outer plexiform layer (Henle's layer). Alteration in the blood-retinal barrier and ischemia cause disturbances in vascular permeability as well as with the function of Müller cells...
2017: Developments in Ophthalmology
https://www.readbyqxmd.com/read/28350958/photo-controlled-sirna-delivery-and-biomarker-triggered-aiegen-emission-by-upconversion-nayf4-yb-3-tm-3-sio2-nanoparticles-for-inducing-and-monitoring-stem-cell-differentiation
#2
Jinming Li, Chris Wai Tung Leung, Dexter Siu Hong Wong, Jianbin Xu, Rui Li, Yueyue Zhao, Chris Yu Yee Yung, Engui Zhao, Benzhong Tang, Liming Bian
Controlling differentiation of stem cell and monitoring the cell differentiation has attracted much research interest since the discovery of stem cells. In this regard, a novel and personalized near-infrared (NIR) light-activated nanoplatform is obtained by encapsulating the photoactivated caged compound (DMNPE/siRNA) and combining a MMP13 cleavaged imaging peptide-tetrapheny-lethene (TPE) unit conjugated with the mesoporous silica coated upconversion nanoparticles (UCNPs) for the remote control of cell differentiation and simultaneously for real-time monitoring of differentiation...
March 28, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28350825/antarctica-and-the-strategic-plan-for-biodiversity
#3
Steven L Chown, Cassandra M Brooks, Aleks Terauds, Céline Le Bohec, Céline van Klaveren-Impagliazzo, Jason D Whittington, Stuart H M Butchart, Bernard W T Coetzee, Ben Collen, Peter Convey, Kevin J Gaston, Neil Gilbert, Mike Gill, Robert Höft, Sam Johnston, Mahlon C Kennicutt, Hannah J Kriesell, Yvon Le Maho, Heather J Lynch, Maria Palomares, Roser Puig-Marcó, Peter Stoett, Melodie A McGeoch
The Strategic Plan for Biodiversity, adopted under the auspices of the Convention on Biological Diversity, provides the basis for taking effective action to curb biodiversity loss across the planet by 2020-an urgent imperative. Yet, Antarctica and the Southern Ocean, which encompass 10% of the planet's surface, are excluded from assessments of progress against the Strategic Plan. The situation is a lost opportunity for biodiversity conservation globally. We provide such an assessment. Our evidence suggests, surprisingly, that for a region so remote and apparently pristine as the Antarctic, the biodiversity outlook is similar to that for the rest of the planet...
March 2017: PLoS Biology
https://www.readbyqxmd.com/read/28346763/direct-noncovalent-activation-of-%C3%AE-%C3%AE-unsaturated-aldehydes-for-the-stereodivergent-synthesis-of-substituted-cyclohexenes
#4
Ji-Kang Xie, Yang Wang, Jun-Bing Lin, Xiao-Rui Ren, Peng-Fei Xu
HOMO-raising noncovalent activation of α-aryl α,β-unsaturated aldehydes using bifunctional Brønsted base catalyst is achieved. The catalytically generated dienolate intermediate undergoes all-carbon [4+2]-cyclizations with nitroolefins, leading to chiral cyclohexenes with four contiguous stereocenters in high yields with excellent enantioseletivities. Furthermore, the diastereodivergent synthesis of the products is realized by introducing a second steric control element to the bifunctional catalyst, and 4 isomers out of 16 possible stereoisomers of the products were selectively produced by simple use of two catalysts and their (pseudo)enantiomers...
March 27, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28346668/demographic-and-preliminary-employment-data-of-the-first-two-graduate-cohorts-from-a-rural-veterinary-school
#5
J H Hyams, S L Raidal, L M Hayes, J Heller
OBJECTIVE: To report initial career experiences and graduate employment destinations 1 and 5 years following graduation of the 67 graduates from the first two graduating classes of the veterinary science program at Charles Sturt University. DESIGN: Online survey of graduates from the 2010 and 2011 cohorts undertaken 12 months following course completion and descriptive data on graduate practice locations 5 years post-graduation. PROCEDURE: Questions covered general demographic information, issues relating to work-life balance and factors influencing vocational choices...
April 2017: Australian Veterinary Journal
https://www.readbyqxmd.com/read/28346604/blended-learning-educational-format-for-third-year-pediatrics-clinical-rotation
#6
Erik E Langenau, Robert Lee, Marci Fults
CONTEXT: Traditional medical education is shifting to incorporate learning technologies and online educational activities with traditional face-to-face clinical instruction to engage students, especially at remote clinical training sites. OBJECTIVE: To describe and evaluate the effectiveness of the blended learning format (combining online and face-to-face instruction) for third-year osteopathic medical students during their pediatric rotation. METHODS: Third-year medical students who completed the 4-week clerkship in pediatrics during the 2014-2015 academic year were divided into a standard learning group and a blended learning group with online activities (discussion boards, blogs, virtual patient encounters, narrated video presentations, and online training modules)...
April 1, 2017: Journal of the American Osteopathic Association
https://www.readbyqxmd.com/read/28346067/horseback-riding-therapy-for-a-deafblind-individual-enabled-by-a-haptic-interface
#7
Matjaž Ogrinc Ms, Ildar Farkhatdinov PhD, Rich Walker Ms, Etienne Burdet
We present a haptic interface to help deafblind people to practice horseback riding as a recreational and therapeutic activity. Horseback riding is a form of therapy which can improve self-esteem and sensation of independence. It has been shown to benefit people with various medical conditions-including autism. However, in the case of deafblind riders, an interpreter must stand by at all times to communicate with the rider by touch. We developed a simple interface that enables deafblind people to enjoy horseback riding while the instructor is remotely providing cues, which improves their independence...
March 27, 2017: Assistive Technology: the Official Journal of RESNA
https://www.readbyqxmd.com/read/28346038/recruitment-and-testing-protocol-in-the-national-eye-health-survey-a-population-based-eye-study-in-australia
#8
Joshua Foreman, Stuart Keel, Peter van Wijngaarden, Hugh R Taylor, Mohamed Dirani
PURPOSE: To present the recruitment and testing methodology of the National Eye Health Survey (NEHS), a population-based study that aimed to determine the prevalence and causes of vision impairment and blindness in Australia. METHODS: Non-Indigenous Australians aged 50 years and older and Indigenous Australians aged 40 years and older were recruited using a door-to-door approach from 30 randomly selected geographical areas, stratified by remoteness. Participants underwent a vision examination, anterior segment assessment, intraocular pressure testing, perimetry, and fundus photography...
March 27, 2017: Ophthalmic Epidemiology
https://www.readbyqxmd.com/read/28345752/recent-field-experiments-with-commercial-satellite-imagery-direct-downlink
#9
Anthony R Gonzalez, Samuel H Amber
US Pacific Command's strategy includes assistance to United States government relief agencies and nongovernment organizations during humanitarian aid and disaster relief operations in the Asia-Pacific region. Situational awareness during these operations is enhanced by broad interagency access to unclassified commercial satellite imagery. The Remote Ground Terminal-a mobile satellite downlink ground station-has undergone several technology demonstrations and participated in an overseas deployment exercise focused on a natural disaster scenario...
January 2017: Journal of Emergency Management: JEM
https://www.readbyqxmd.com/read/28345431/collaterals-2016-translating-the-collaterome-around-the-globe
#10
David S Liebeskind, Graham W Woolf, Ashfaq Shuaib
Collaterals 2016 (third International Symposium on Collaterals to the Brain) was a multidisciplinary scientific conference focused on collateral circulation in acute ischemic stroke. Decisive challenges include generalizability of optimal triage and selection paradigms based on collateral status for definitive treatment of acute ischemic stroke, rapid dissemination of expert methods, and the urgent need to leverage networking opportunities for stroke science related to the hemodynamics of collaterals. The collaterome, or individual capacity to offset ischemia in the brain, and determination of a favorable collateral profile have become pivotal factors in consideration of the precision medicine of stroke decision-making...
January 1, 2017: International Journal of Stroke: Official Journal of the International Stroke Society
https://www.readbyqxmd.com/read/28345103/1-2-difunctionalization-type-hetero-arylation-of-unactivated-alkenes-triggered-by-radical-addition-remote-hetero-aryl-migration
#11
Lei Li, Qiang-Shuai Gu, Na Wang, Ping Song, Zhong-Liang Li, Xiao-Hua Li, Fu-Li Wang, Xin-Yuan Liu
A novel difunctionalization-type (hetero)arylation of unactivated alkenes has been developed via remote 1,4(5)-(hetero)aryl migration triggered by radical alkene azidation, trifluoromethylation, or phosphonylation. The overall process serves as an unusual and reliable approach for straightforward access to diversely substituted ketones with broad functional group compatibility from readily available substrates and reagents.
March 27, 2017: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/28344899/a-multidisciplinary-approach-to-digital-mapping-of-dinosaurian-tracksites-in-the-lower-cretaceous-valanginian-barremian-broome-sandstone-of-the-dampier-peninsula-western-australia
#12
Anthony Romilio, Jorg M Hacker, Robert Zlot, George Poropat, Michael Bosse, Steven W Salisbury
The abundant dinosaurian tracksites of the Lower Cretaceous (Valanginian-Barremian) Broome Sandstone of the Dampier Peninsula, Western Australia, form an important part of the West Kimberley National Heritage Place. Previous attempts to document these tracksites using traditional mapping techniques (e.g., surface overlays, transects and gridlines combined with conventional photography) have been hindered by the non-trivial challenges associated with working in this area, including, but not limited to: (1) the remoteness of many of the tracksites; (2) the occurrence of the majority of the tracksites in the intertidal zone; (3) the size and complexity of many of the tracksites, with some extending over several square kilometres...
2017: PeerJ
https://www.readbyqxmd.com/read/28344616/the-impact-of-a-single-episode-of-remote-ischemic-preconditioning-on-myocardial-injury-after-elective-percutaneous-coronary-intervention
#13
Mustafa A Yılmaztepe, Gökay Taylan, Meryem Aktoz, Hanefi Y Gürlertop, Yüksel Aksoy, Fatih Özçelik, Kenan Yalta, Galip Ekuklu
INTRODUCTION: Myocardial injury after percutaneous coronary intervention (PCI) occurs in approximately 30% of procedures, and is related to worse prognosis. Effects of remote ischemic preconditioning (RIPC) on reperfusion injury have been investigated before, yielding conflicting results. AIM: To assess the impact of a single episode of RIPC on myocardial injury after elective PCI. MATERIAL AND METHODS: One hundred and four patients undergoing elective PCI, with normal baseline cardiac troponin-I (cTn-I) values, were randomized to two groups...
2017: Postępy W Kardiologii Interwencyjnej, Advances in Interventional Cardiology
https://www.readbyqxmd.com/read/28344325/the-giant-deep-sea-octopus-haliphron-atlanticus-forages-on-gelatinous-fauna
#14
H J T Hoving, S H D Haddock
Feeding strategies and predator-prey interactions of many deep-sea pelagic organisms are still unknown. This is also true for pelagic cephalopods, some of which are very abundant in oceanic ecosystems and which are known for their elaborate behaviors and central role in many foodwebs. We report on the first observations of the giant deep-sea octopus Haliphron atlanticus with prey. Using remotely operated vehicles, we saw these giant octopods holding medusae in their arms. One of the medusae could be identified as Phacellophora camtschatica (the egg-yolk jelly)...
March 27, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28344036/focus-the-interface-between-data-collection-and-data-processing-in-cryo-em
#15
Nikhil Biyani, Ricardo D Righetto, Robert McLeod, Daniel Caujolle-Bert, Daniel Castano-Diez, Kenneth N Goldie, Henning Stahlberg
We present a new software package called Focus that interfaces cryo-transmission electron microscopy (cryo-EM) data collection with computer image processing. Focus creates a user-friendly environment to import and manage data recorded by direct electron detectors and perform elemental image processing tasks in a high-throughput manner while new data is being acquired at the microscope. It provides the functionality required to remotely monitor the progress of data collection and data processing, which is essential now that automation in cryo-EM allows a steady flow of images of single particles, two-dimensional crystals, or electron tomography data to be recorded in overnight sessions...
March 23, 2017: Journal of Structural Biology
https://www.readbyqxmd.com/read/28343763/identifying-high-risk-post-infarction-patients-by-autonomic-testing-below-the-tip-of-the-iceberg
#16
Axel Bauer
Despite major advances in medical therapies late mortality after myocardial infarction (MI) is still high. A substantial proportion of post-MI patients die from sudden cardiac death. Prophylactic implantable-cardioverter defibrillator (ICD) therapy has been established for post-MI patients with reduced left ventricular ejection fraction (LVEF ≤35%). However, most patients who die after MI have an LVEF >35%. For this large group of patients, no specific prophylactic strategies exist. There is strong evidence that measures of cardiac autonomic dysfunction after MI provide important prognostic information in post-MI patients with preserved LVEF...
March 18, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28343464/life-lifestyle-and-location-examining-the-complexities-of-psychological-distress-in-young-adult-indigenous-and-non-indigenous-australians
#17
B Davison, T Nagel, G R Singh
Mental health is fundamental to an individual's health and well-being. Mental health disorders affect a substantial portion of the Australian population, with the most vulnerable time in adolescence and young adulthood. Indigenous Australians fare worse than other Australians on almost every measure of physical and mental health. Cross-sectional data from young adults (21-27 years) participating in the Life Course Program, Northern Territory, Australia, is presented. Rates of psychological distress were high in remote and urban residing Indigenous and urban non-Indigenous young adults...
March 27, 2017: Journal of Developmental Origins of Health and Disease
https://www.readbyqxmd.com/read/28342070/normative-data-for-chinese-compound-remote-associate-problems
#18
Ching-Lin Wu, Hsueh-Chih Chen
The Remote Associates Test (RAT) is a well-known measure of creativity, with each item on the RAT is composed of three unrelated stimulus words. The participant's task is to find an answer in the form of a word that could combine with each of the stimulus words, thus forming three new actual nouns. Researchers have modified the RAT to develop compound remote associate problems that emphasize combining vocabulary to form compound words. In the field of creativity research for Mandarin speakers, the Chinese RAT has been widely applied for over 10 years...
March 24, 2017: Behavior Research Methods
https://www.readbyqxmd.com/read/28341642/feasibility-and-accuracy-of-teleconcussion-for-acute-evaluation-of-suspected-concussion
#19
Bert B Vargas, Morgan Shepard, Joseph G Hentz, Cherisse Kutyreff, L George Hershey, Amaal J Starling
OBJECTIVE: To assess the feasibility and accuracy of telemedical concussion evaluations (teleconcussion) for real-time athletic sideline assessment of concussion, as such assessment may address the gap in access some populations of athletes have to providers with expertise in concussion evaluation. METHODS: A cohort of 11 consecutive male collegiate football players with suspected concussion was assessed using Standardized Assessment of Concussion (SAC), King-Devick test (K-D), and modified Balance Error Scoring System (mBESS)...
March 24, 2017: Neurology
https://www.readbyqxmd.com/read/28341615/design-and-usability-of-a-heart-failure-mhealth-system-a-pilot-study
#20
Nagla Alnosayan, Samir Chatterjee, Ala Alluhaidan, Edward Lee, Linda Houston Feenstra
BACKGROUND: Despite the advances in mobile health (mHealth) systems, little is known about patients' and providers' experiences using a new mHealth system design. OBJECTIVE: This study aimed to understand challenges and provide design considerations for a personalized mHealth system that could effectively support heart failure (HF) patients after they transition into the home environment. METHODS: Following exploratory interviews with nurses and preventive care physicians, an mHealth system was developed...
March 24, 2017: JMIR Human Factors
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