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Geoffrey H Tison, José M Sanchez, Brandon Ballinger, Avesh Singh, Jeffrey E Olgin, Mark J Pletcher, Eric Vittinghoff, Emily S Lee, Shannon M Fan, Rachel A Gladstone, Carlos Mikell, Nimit Sohoni, Johnson Hsieh, Gregory M Marcus
Importance: Atrial fibrillation (AF) affects 34 million people worldwide and is a leading cause of stroke. A readily accessible means to continuously monitor for AF could prevent large numbers of strokes and death. Objective: To develop and validate a deep neural network to detect AF using smartwatch data. Design, Setting, and Participants: In this multinational cardiovascular remote cohort study coordinated at the University of California, San Francisco, smartwatches were used to obtain heart rate and step count data for algorithm development...
March 21, 2018: JAMA Cardiology
Ciro Romano, Clément Mazet
Starting from readily available alkenyl methyl ethers, the stereoselective preparation of highly substituted alkenes by two complementary multicatalytic sequential isomerization/cross-coupling sequences is described. Both elementary steps of these sequences are challenging processes when considered independently. A cationic iridium catalyst was identified for the stereoselective isomerization of allyl methyl ethers and was found to be compatible with a nickel catalyst for the subsequent cross-coupling of the in situ generated methyl vinyl ethers with various Grignard reagents...
March 21, 2018: Journal of the American Chemical Society
Markus Selmke, Utsab Khadka, Andreas P Bregulla, Frank Cichos, Haw Yang
Photon nudging is a new experimental method which enables the force-free manipulation and localization of individual self-propelled artificial micro-swimmers in fluidic environments. It uses a weak laser to stochastically and adaptively turn on and off the swimmer's propulsion when the swimmer, through rotational diffusion, points towards or away from its target, respectively. This contribution presents a theoretical framework for the statistics of both 2D and 3D controls. The main results are: the on- and off-time distributions for the controlling laser, the arrival time statistics for the swimmer to reach a remote target, and how the experimentally accessible control parameters influence the control, e...
March 21, 2018: Physical Chemistry Chemical Physics: PCCP
Dalton B Burks, Shakeyia Davis, Robert W Lamb, Xuan Liu, Roberta R Rodrigues, Nalaka P Liyanage, Yujie Sun, Charles Edwin Webster, Jared H Delcamp, Elizabeth T Papish
The first example of a CNC pincer ligand with a central pyridinol ligand is reported in a nickel(ii) complex. This metal complex can be protonated or deprotonated reversibly in situ to switch on or off the photocatalytic performance towards CO2 reduction. The O- substituent appears essential for catalysis.
March 21, 2018: Chemical Communications: Chem Comm
Damien Christophe Jacques, Eduardo Marinho, Raphaël d'Andrimont, François Waldner, Julien Radoux, Frédéric Gaspart, Pierre Defourny
In sub-Saharan Africa, transaction costs are believed to be the most significant barrier that prevents smallholders and farmers from gaining access to markets and productive assets. In this study, we explore the impact of social capital on millet prices for three contrasted years in Senegal. Social capital is approximated using a unique data set on mobile phone communications between 9 million people allowing to simulate the business network between economic agents. Our approach is a spatial equilibrium model that integrates a diversified set of data...
January 2018: Heliyon
Lucy Mackillop, Jane Elizabeth Hirst, Katy Jane Bartlett, Jacqueline Susan Birks, Lei Clifton, Andrew J Farmer, Oliver Gibson, Yvonne Kenworthy, Jonathan Cummings Levy, Lise Loerup, Oliver Rivero-Arias, Wai-Kit Ming, Carmelo Velardo, Lionel Tarassenko
BACKGROUND: Treatment of hyperglycemia in women with gestational diabetes mellitus (GDM) is associated with improved maternal and neonatal outcomes and requires intensive clinical input. This is currently achieved by hospital clinic attendance every 2 to 4 weeks with limited opportunity for intervention between these visits. OBJECTIVE: We conducted a randomized controlled trial to determine whether the use of a mobile phone-based real-time blood glucose management system to manage women with GDM remotely was as effective in controlling blood glucose as standard care through clinic attendance...
March 20, 2018: JMIR MHealth and UHealth
Esben S Worm, Morten Høyer, Rune Hansen, Lars P Larsen, Britta Weber, Cai Grau, Per R Poulsen
PURPOSE: Intrafraction motion can compromise the treatment accuracy in liver stereotactic body radiation therapy (SBRT). Respiratory gating can improve treatment delivery; however, gating based on external motion surrogates is inaccurate. The present study reports the use of Calypso-based internal electromagnetic motion monitoring for gated liver SBRT. METHODS AND MATERIALS: Fifteen patients were included in a study of 3-fraction respiratory gated liver SBRT guided by 3 implanted electromagnetic transponders...
February 13, 2018: International Journal of Radiation Oncology, Biology, Physics
Yoav Yaakov Biton
The statistical mechanics of a short circularized DNA molecule, a DNA minicircle, with prescribed linking number depends heavily on the mechanical and geometrical properties of the DNA, which are known to be functions of the sequence. A description of a general numerical scheme used for our advanced simulation is presented with examples that reveal the effects of sequence dependence and local deformations, caused by protein binding, on the configurations in a canonical ensemble of a supercoiled minicircle. Using a realistic course grain model in which the sequence-dependent elasticity, the intra-molecular electrostatic interactions, and the impenetrability of the DNA molecule are taken into account, we show the bifurcation of equilibria of supercoiled minicircle DNA with the induced bending as a parameter...
March 20, 2018: Journal of Chemical Theory and Computation
Judy Tan, Anita Mehrotra, Girish N Nadkarni, John Cijiang He, Erik Langhoff, James Post, Carlos Galvao-Sobrinho, Henry C Thode, Rajeev Rohatgi
BACKGROUND: Chronic kidney disease (CKD) patients who live far (>30 miles) from their nephrologist experience lower rates of clinic visit adherence, limited access to treatment, and higher rates of hospitalization and mortality than patients who live in close proximity to their nephrologist. Strategies to minimize disparities between urban and remotely located CKD patients are needed. The purpose of this study was to determine whether adherence to clinic visits and clinical outcomes in the remote management of CKD via telenephrology is comparable to in-person conventional care...
March 20, 2018: American Journal of Nephrology
Aamer Saeed, Mubeen Arif, Mauricio F Erben, Ulrich Flörke, Jim Simpson
Two closely related hybrid species containing both, thiazolyl and coumarin groups, were synthesized by using two different one-pot procedures from a common precursor. The reaction of α-bromoacetylcoumarin with thioacetamide in methanol furnished 3‑(2‑methylthiazol‑4‑yl)‑2H‑chromen‑2‑one (2), whereas refluxing α‑bromoacetylcoumarin with potassium thiocyanate in ethanol afforded 3‑(2‑ethoxythiazol‑4‑yl)‑2H‑chromen‑2‑one (3). Both derivatives were fully characterized by spectroscopic methods, elemental analysis and X-ray diffraction studies...
March 13, 2018: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
Sue Rodway-Dyer, Nicola Ellis
Footpaths are a prominent consequence of natural area tourism and reflect damage caused to valuable, sensitive habitats by people pressure. Degradation impacts on vegetation, wildlife, on and off-site soil movement and loss, creation of additional informal off-path footpaths (desire lines), and visual destruction of landscapes. Impacts need to be measured and monitored on a large temporal and spatial scale to aid in land management to maintain access and preserve natural environments. This study combined remote sensing (Light Detection and Ranging [LiDAR] and aerial photography) with on-site measurement of footpaths within a sensitive heathland habitat (Land's End, Cornwall, UK)...
March 17, 2018: Journal of Environmental Management
Ali Al-Naji, Javaan Chahl
Monitoring of cardiopulmonary activity is a challenge when attempted under adverse conditions, including different sleeping postures, environmental settings, and an unclear region of interest (ROI). This study proposes an efficient remote imaging system based on a Microsoft Kinect v2 sensor for the observation of cardiopulmonary-signal-and-detection-related abnormal cardiopulmonary events (e.g., tachycardia, bradycardia, tachypnea, bradypnea, and central apnoea) in many possible sleeping postures within varying environmental settings including in total darkness and whether the subject is covered by a blanket or not...
March 20, 2018: Sensors
Emma Fauss
No abstract text is available yet for this article.
March 2018: Biomedical Instrumentation & Technology
Jin-Xuan Fan, Zi-Hao Li, Xin-Hua Liu, Diwei Zheng, Ying Chen, Xian-Zheng Zhang
Oral drug administration is widely adopted for diverse drugs, and enjoys the convenience of use and capbility to reach different parts of the body via the bloodstream. However, it is generally not feasible for biomacromolecular anti-tumor drugs such as protein and nucleic acids due to the the limited absorption through gastrointestinal tract (GIT) and the poor tumor targeting. Here, we report a non-invasive thermally-sensitive programmable therapetic system using bacteria E. coli MG1655 as an vehicle for tumor treatments via oral administration...
March 20, 2018: Nano Letters
Paul P Walker, Pasquale P Pompilio, Paolo Zanaboni, Trine S Bergmo, Kaiu Prikk, Andrei Malinovschi, Josep M Montserrat, Jo Middlemass, Silvana Šonc, Giulia Munaro, Dorjan Marušič, Ruth Sepper, Roberto Rosso, A Niroshan Siriwardena, Christer Janson, Ramon Farre, Peter M A Calverley, Raffaele L Dellaca'
RATIONALE: Early detection of COPD exacerbations using tele-monitoring of physiological variables might reduce the frequency of hospitalisation. OBJECTIVES: To evaluate the efficacy of home monitoring of lung mechanics by the forced oscillation technique (FOT) and cardiac parameters in older COPD patients with co-morbidities. METHODS: This multicentre, randomized clinical trial recruited 312 GOLD grade II-IV COPD patients (median age 71 years [IQR:66-76], 49...
March 20, 2018: American Journal of Respiratory and Critical Care Medicine
Mimi M Li, Mohamad S Hamady, Colin D Bicknell, Celia V Riga
Flexible robotic catheters are an emerging technology which provide an elegant solution to the challenges of conventional endovascular intervention. Originally developed for interventional cardiology and electrophysiology procedures, remotely steerable robotic catheters such as the Magellan system enable greater precision and enhanced stability during target vessel navigation. These technical advantages facilitate improved treatment of disease in the arterial tree, as well as allowing execution of otherwise unfeasible procedures...
March 19, 2018: Journal of Cardiovascular Surgery
Abir Goswami, Susnata Pramanik, Michael Schmittel
A catalytically active three-component nanorotor is reversibly self-assembled and disassembled by remote control. When zinc(ii) ions (2 equiv.) are added as an external chemical trigger to the mixture of transmitter [Cu(1)]+ and pre-rotor assembly [(S)·(R)], two equiv. of copper(i) ions translocate from [Cu(1)]+ to the two phenanthroline sites of [(S)·(R)]. As a result, [Zn(1)]2+ forms along with the three-component assembly [Cu2(S)(R)]2+, which is both a nanorotor (k298 = 46 kHz, ΔH‡ = 49.1 ± 0.4 kJ mol-1, ΔS‡ = 9...
March 20, 2018: Chemical Communications: Chem Comm
Simon J Mitchell, Michael H Bennett, Phillip Bryson, Frank K Butler, David J Doolette, James R Holm, Jacek Kot, Pierre Lafère
Guidelines for the pre-hospital management of decompression illness (DCI) had not been formally revised since the 2004 Divers Alert Network/Undersea and Hyperbaric Medical Society workshop held in Sydney, entitled "Management of mild or marginal decompression illness in remote locations". A contemporary review was initiated by the Diver's Alert Network and undertaken by a multinational committee with members from Australasia, the USA and Europe. The process began with literature reviews by designated committee members on: the diagnosis of DCI; first aid strategies for DCI; remote triage of possible DCI victims by diving medicine experts; evacuation of DCI victims; effect of delay to recompression in DCI; pitfalls in management when DCI victims present at hospitals without diving medicine expertise and in-water recompression...
March 31, 2018: Diving and Hyperbaric Medicine: the Journal of the South Pacific Underwater Medicine Society
Syed M Tareq, M Tauhid Ur Rahman, A Z M Zahedul Islam, A B M Baddruzzaman, M Ashraf Ali
Climate-induced waterlogging has been significantly affecting the lives and livelihood of people in the south-west coastal region of Bangladesh for a couple of decades. The objective of this study is to investigate the waterlogging hazards of Tala, a south-western coastal Upazila of Bangladesh by analyzing satellite image. An empirical model based on velocity of flow, depth of flow, and inundation depth has been proposed to assess waterlogging hazard in pre monsoon, monsoon, and post monsoon period. Landsat TM images for the years 1989, 2000, and 2011 were analyzed by using Geoinformatics including GIS and remote sensing techniques to quantify the water hazard...
March 19, 2018: Environmental Monitoring and Assessment
Marita Crivelli, Kaspar Wyss, Leticia Grize, Barbara Matthys, Thomas Aebi, Elisabeth Zemp
OBJECTIVES: To assess the association between overweight/obesity and anemia in early childhood in Tajikistan. METHODS: Using a two-stage-cluster sampling, a representative sample of 1342 children (48.7% girls) aged 25-60 months was included in a nationwide survey in Tajikistan in 2009. Weight status was defined by age- and gender-specific body mass index, anemia by hemoglobin < 11 g/dl, according to WHO cut-off values for children, adjusted for altitude...
March 19, 2018: International Journal of Public Health
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