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https://www.readbyqxmd.com/read/29346753/sonic-hedgehog-is-a-remotely-produced-cue-that-controls-axon-guidance-trans-axonally-at-a-midline-choice-point
#1
Jimmy Peng, Pierre J Fabre, Tiphaine Dolique, Shannon M Swikert, Laëtitia Kermasson, Tomomi Shimogori, Frédéric Charron
At the optic chiasm choice point, ipsilateral retinal ganglion cells (RGCs) are repelled away from the midline by guidance cues, including Ephrin-B2 and Sonic Hedgehog (Shh). Although guidance cues are normally produced by cells residing at the choice point, the mRNA for Shh is not found at the optic chiasm. Here we show that Shh protein is instead produced by contralateral RGCs at the retina, transported anterogradely along the axon, and accumulates at the optic chiasm to repel ipsilateral RGCs. In vitro, contralateral RGC axons, which secrete Shh, repel ipsilateral RGCs in a Boc- and Smo-dependent manner...
January 17, 2018: Neuron
https://www.readbyqxmd.com/read/29346746/shh-ushing-midline-crossing-through-remote-protein-transport
#2
Eloísa Herrera, Austen A Sitko, Paola Bovolenta
Shh contributes to neural circuit formation with different mechanisms. In this issue, Peng and colleagues (2018) identify a novel trans-axonal mechanism by which Shh derived from contralateral projecting retinal ganglion cells prevents midline crossing of Boc-expressing ipsilateral axons at the optic chiasm.
January 17, 2018: Neuron
https://www.readbyqxmd.com/read/29346726/the-effect-of-dielectric-environment-on-doping-efficiency-in-colloidal-pbse-nanostructures
#3
Qinghua Zhao, Tianshuo Zhao, Jiacen Guo, Wenxiang Chen, Mingliang Zhang, Cherie R Kagan
Doping, as a central strategy to control free carrier type and concentration in semiconductor materials, suffers from low efficiency at the nanoscale, especially in systems having high permittivity (ϵ) and large Bohr radii, such as lead chalcogenide nanocrystals (NCs) and nanowires (NWs). Here, we study dielectric confinement effects on the doping efficiency of lead chalcogenides nanostructures by integrating PbSe NWs in the platform of field effect transistors (FETs). Elemental Pb or In or elemental Se is deposited by thermal evaporation to remotely n- or p-dope the NWs...
January 18, 2018: ACS Nano
https://www.readbyqxmd.com/read/29346441/a-portable-system-for-processing-donated-whole-blood-into-high-quality-components-without-centrifugation
#4
Sean C Gifford, Briony C Strachan, Hui Xia, Eszter Vörös, Kian Torabian, Taylor A Tomasino, Gary D Griffin, Benjamin Lichtiger, Fleur M Aung, Sergey S Shevkoplyas
BACKGROUND: The use of centrifugation-based approaches for processing donated blood into components is routine in the industrialized world, as disparate storage conditions require the rapid separation of 'whole blood' into distinct red blood cell (RBC), platelet, and plasma products. However, the logistical complications and potential cellular damage associated with centrifugation/apheresis manufacturing of blood products are well documented. The objective of this study was to evaluate a proof-of-concept system for whole blood processing, which does not employ electromechanical parts, is easily portable, and can be operated immediately after donation with minimal human labor...
2018: PloS One
https://www.readbyqxmd.com/read/29346430/estimation-of-inhalation-flow-profile-using-audio-based-methods-to-assess-inhaler-medication-adherence
#5
Terence E Taylor, Helena Lacalle Muls, Richard W Costello, Richard B Reilly
Asthma and chronic obstructive pulmonary disease (COPD) patients are required to inhale forcefully and deeply to receive medication when using a dry powder inhaler (DPI). There is a clinical need to objectively monitor the inhalation flow profile of DPIs in order to remotely monitor patient inhalation technique. Audio-based methods have been previously employed to accurately estimate flow parameters such as the peak inspiratory flow rate of inhalations, however, these methods required multiple calibration inhalation audio recordings...
2018: PloS One
https://www.readbyqxmd.com/read/29346217/pathological-and-molecular-aspects-to-improve-endoscopic-ultrasonography-guided-fine-needle-aspiration-from-solid-pancreatic-lesions
#6
Hiroyuki Matsubayashi, Keiko Sasaki, Sachiyo Ono, Masato Abe, Hirotoshi Ishiwatari, Akira Fukutomi, Katsuhiko Uesaka, Hiroyuki Ono
Endoscopic ultrasonography-guided fine-needle aspiration (EUS-FNA) has been applied to pancreatic lesions since the 1990s, and its use is now widespread. Improvements in endoscopic devices and sampling techniques have resulted in excellent diagnostic ability for solid pancreatic lesions. However, clinical improvements alone are not responsible for it; pathological aspects have also played important roles. Rapid on-site evaluation minimizes endoscopic procedures, although its value at improving the diagnostic ratio is still debated...
February 2018: Pancreas
https://www.readbyqxmd.com/read/29346097/change-detection-in-heterogenous-remote-sensing-images-via-homogeneous-pixel-transformation
#7
Zhunga Liu, Gang Li, Gregoire Mercier, You He, Quan Pan
The change detection in heterogeneous remote sensing images remains an important and open problem for damage assessment. We propose a new change detection method for heterogeneous images (i.e., SAR and optical images) based on homogeneous pixel transformation (HPT). HPT transfers one image from its original feature space (e.g., gray space) to another space (e.g., spectral space) in pixel-level to make the pre-event and post-event images represented in a common space for the convenience of change detection. HPT consists of two operations, i...
April 2018: IEEE Transactions on Image Processing: a Publication of the IEEE Signal Processing Society
https://www.readbyqxmd.com/read/29346039/evaluation-of-a-french-regional-telemedicine-network-dedicated-to-neurological-emergencies-a-14-year-study
#8
Elisabeth Medeiros de Bustos, Eric Berthier, Didier Chavot, Benjamin Bouamra, Thierry Moulin
BACKGROUND: Equality in healthcare between urban and rural areas is problematic in France. Telemedicine networks are expected to improve equality in expertise assessment. We aimed to evaluate the use and impact of a regional rural French telemedicine network, dedicated to medical and surgical neurological emergencies, on interhospital patient transfers. METHODS: Eight community hospital emergency departments were remotely connected to the only university hospital in Franche-Comté, France...
January 18, 2018: Telemedicine Journal and E-health: the Official Journal of the American Telemedicine Association
https://www.readbyqxmd.com/read/29345002/remote-c-h-activation-of-various-n-heterocycles-using-a-single-template
#9
Guoqiang Yang, Dajian Zhu, Peng Wang, Ri-Yuan Tang, Jin-Quan Yu
A single simple ortho-sulfonyl benzonitrile template was developed to achieve remote C-H olefination of six different classes of N-heterocycles. We demonstrate that, by varying precatalysts and conditions, the same template can be applied to the remote C-H activation of six structurally distinct heterocyclic scaffolds, and the site-selectivity can be predicted based on distance and geometry. Furthermore, this new development shows that template-directed remote C-H activation are possible via macrocyclopalladation processes with smaller ring sizes...
January 18, 2018: Chemistry: a European Journal
https://www.readbyqxmd.com/read/29344650/adrenomedullin-serves-a-role-in-the-humoral-pathway-of-delayed-remote-ischemic-preconditioning-via-a-hypoxia-inducible-factor-1%C3%AE-associated-mechanism
#10
Wenpei Dong, Ping Yu, Tielong Zhang, Chenzhuang Zhu, Jun Qi, Junhao Liang
Remote ischemic preconditioning (RIPC) is a minimally invasive method that provides protection by reducing injury to the heart, kidneys, brain and other tissues or organs. RIPC may improve the outcome in patients undergoing surgery. Although the role of RIPC has been studied, the results remain controversial. It is difficult to confirm whether RIPC has a kidney protective effect and the understanding of the preconditioning signal pathway involved remains unclear. In the present study, the effect of RIPC in urology was evaluated...
January 17, 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29344487/enlarging-pigmented-eyelid-mass-associated-with-remote-pencil-trauma
#11
Paul O Phelps, J Andrew Carlson, Dale R Meyer
The authors present a case of a gradually enlarging pigmented mass of the upper eyelid and anterior orbit that was discovered to be the graphite tip of a pencil surrounded by macrophages bearing graphite and fibrous tissue. A 25-year-old woman with no medical history presented with a gradually enlarging pigmented lesion of her left upper eyelid. She denied any history of previous skin cancer, trauma, or previous surgery. A biopsy was performed. This revealed an encapsulated grayish, pigmented mass within the medial portion of the left upper eyelid and anterior orbit...
November 2017: Ocular Oncology and Pathology
https://www.readbyqxmd.com/read/29343852/a-new-class-of-magnetically-actuated-pumps-and-valves-for-microfluidic-applications
#12
Joshua K Hamilton, Matthew T Bryan, Andrew D Gilbert, Feodor Y Ogrin, Thomas O Myers
We propose a new class of magnetically actuated pumps and valves that could be incorporated into microfluidic chips with no further external connections. The idea is to repurpose ferromagnetic low Reynolds number swimmers as devices capable of generating fluid flow, by restricting the swimmers' translational degrees of freedom. We experimentally investigate the flow structure generated by a pinned swimmer in different scenarios, such as unrestricted flow around it as well as flow generated in straight, cross-shaped, Y-shaped and circular channels...
January 17, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29343840/vision-status-in-older-adults-the-brazilian-amazon-region-eye-survey
#13
Solange R Salomão, Adriana Berezovsky, João M Furtado, Arthur G Fernandes, Sergio Muñoz, Nívea N Cavascan, Marcela C Cypel, Cristina C Cunha, Galton C Vasconcelos, Márcia R K H Mitsuhiro, Paula Y Sacai, Mauro Campos, Paulo H A Morales, Marcos J Cohen, Jacob M Cohen, Sung E S Watanabe, Rubens Belfort
Older adults living in remote areas with limited access to health services are at higher risk to develop visual impairment and blindness. We conducted a population-based survey to determine the vision status in subjects 45 years of age and older from urban and rural areas of Parintins city, Brazilian Amazon Region. Participants underwent ophthalmic examination, including uncorrected (UCVA), presenting (PVA) and best-corrected visual acuity (BCVA). Vision status was described as lines of visual acuity (VA) impairment and lines of VA improvement from UCVA to BCVA and from PVA to BCVA in the better-seeing eye...
January 17, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29343746/the-static-magnetic-field-remotely-boosts-the-efficiency-of-doxorubicin-through-modulating-ros-behaviors
#14
Behnam Hajipour Verdom, Parviz Abdolmaleki, Mehrdad Behmanesh
Exposure to magnetic field (MF) can affect cellular metabolism remotely. Cardio-toxic effects of Doxorubicin (DOXO) have limited clinical uses at high dose. MF due to its effect on reactive oxygen species (ROS) lifetime, may provide a suitable choice to boost the efficacy of this drug at low dose. Here, we investigated the potential effects of homogenous static magnetic field (SMF) on DOXO-induced toxicity and proliferation rate of cancer cells. The results indicated that SMF similar to DOXO decreased the cell viability as well as the proliferation rate of MCF-7 and HFF cells...
January 17, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29343730/first-estimates-of-greenland-shark-somniosus-microcephalus-local-abundances-in-arctic-waters
#15
Brynn M Devine, Laura J Wheeland, Jonathan A D Fisher
Baited remote underwater video cameras were deployed in the Eastern Canadian Arctic, for the purpose of estimating local densities of the long-lived Greenland shark within five deep-water, data-poor regions of interest for fisheries development and marine conservation in Nunavut, Canada. A total of 31 camera deployments occurred between July-September in 2015 and 2016 during joint exploratory fishing and scientific cruises. Greenland sharks appeared at 80% of deployments. A total of 142 individuals were identified and no individuals were observed in more than one deployment...
January 17, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29343642/mechanogenetics-for-the-remote-and-noninvasive-control-of-cancer-immunotherapy
#16
Yijia Pan, Sangpil Yoon, Jie Sun, Ziliang Huang, Changyang Lee, Molly Allen, Yiqian Wu, Ya-Ju Chang, Michel Sadelain, K Kirk Shung, Shu Chien, Yingxiao Wang
While cell-based immunotherapy, especially chimeric antigen receptor (CAR)-expressing T cells, is becoming a paradigm-shifting therapeutic approach for cancer treatment, there is a lack of general methods to remotely and noninvasively regulate genetics in live mammalian cells and animals for cancer immunotherapy within confined local tissue space. To address this limitation, we have identified a mechanically sensitive Piezo1 ion channel (mechanosensor) that is activatable by ultrasound stimulation and integrated it with engineered genetic circuits (genetic transducer) in live HEK293T cells to convert the ultrasound-activated Piezo1 into transcriptional activities...
January 17, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29343434/a-long-distance-relay-tionship-between-tumor-and-bone
#17
Klara Soukup, Johanna A Joyce
Myeloid cells, including neutrophils, are important regulators of tumor growth and metastasis. In Science, Engblom et al. (2017) reveal how lung tumors remotely engage bone-resident cells through a relay mechanism that achieves a sustained supply of tumor-promoting neutrophils.
January 16, 2018: Immunity
https://www.readbyqxmd.com/read/29343055/genetically-encoded-circuit-for-remote-regulation-of-cell-migration-by-magnetic-fields
#18
Abdullah Al Mosabbir, Kevin Truong
Magneto-reception can be generally defined as the ability to transduce the effects of a magnetic field into a cellular response. Magnetic stimulation at the cellular level is particularly attractive due to its ability for deep penetration and minimal invasiveness, allowing remote regulation of engineered biological processes. Previously, a magnetic-responsive genetic circuit was engineered using the transient receptor potential vanilloid 1 (TRPV1) and the iron containing ferritin protein (i.e. the TF circuit)...
January 17, 2018: ACS Synthetic Biology
https://www.readbyqxmd.com/read/29343051/ketamine-and-remote-hyperalgesia
#19
Steven B Porter, Eric S Schwenk
No abstract text is available yet for this article.
January 17, 2018: Minerva Anestesiologica
https://www.readbyqxmd.com/read/29342945/hyperspectral-features-of-oil-polluted-sea-ice-and-the-response-to-the-contamination-area-fraction
#20
Bingxin Liu, Ying Li, Chengyu Liu, Feng Xie, Jan-Peter Muller
Researchers have studied oil spills in open waters using remote sensors, but few have focused on extracting reflectance features of oil pollution on sea ice. An experiment was conducted on natural sea ice in Bohai Bay, China, to obtain the spectral reflectance of oil-contaminated sea ice. The spectral absorption index (SAI), spectral peak height (SPH), and wavelet detail coefficient (DWT d5) were calculated using stepwise multiple linear regression. The reflectances of some false targets were measured and analysed...
January 15, 2018: Sensors
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