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REVIEW
Tales Fernando da Silva, Rafael de Assis Glória, Monique Ferrary Americo, Andria Dos Santos Freitas, Luis Claudio Lima de Jesus, Fernanda Alvarenga Lima Barroso, Juliana Guimarães Laguna, Nina Dias Coelho-Rocha, Laisa Macedo Tavares, Yves le Loir, Gwénaël Jan, Éric Guédon, Vasco Ariston de Carvalho Azevedo
This review provides a comprehensive overview of the current state of probiotic research, covering a wide range of topics, including strain identification, functional characterization, preclinical and clinical evaluations, mechanisms of action, therapeutic applications, manufacturing considerations, and future directions. The screening process for potential probiotics involves phenotypic and genomic analysis to identify strains with health-promoting properties while excluding those with any factor that could be harmful to the host...
March 28, 2024: Probiotics and Antimicrobial Proteins
#22
JOURNAL ARTICLE
Marina Alves, Pedro Anacleto, Vasco Teixeira, Joaquim Carneiro, Sascha Sadewasser
Second-generation thin-film Cu(In, Ga)Se2 (CIGS) solar cells are a well-established photovoltaic technology with a record power conversion efficiency of 23.6%. However, their reliance on critical raw materials, such as In and Ga, requires new approaches to reduce the amount of critical raw materials employed. The micro-concentrator concept involves the combination of thin-film photovoltaic technology with concentrator photovoltaic technology. This approach reduces the size of the solar cell to the micrometer range and uses optical concentration to collect sunlight from a larger area, focusing it onto micro solar cells...
March 20, 2024: Nanomaterials
#23
JOURNAL ARTICLE
Suraj Pai, Dennis Bontempi, Ibrahim Hadzic, Vasco Prudente, Mateo Sokač, Tafadzwa L Chaunzwa, Simon Bernatz, Ahmed Hosny, Raymond H Mak, Nicolai J Birkbak, Hugo J W L Aerts
Foundation models in deep learning are characterized by a single large-scale model trained on vast amounts of data serving as the foundation for various downstream tasks. Foundation models are generally trained using self-supervised learning and excel in reducing the demand for training samples in downstream applications. This is especially important in medicine, where large labelled datasets are often scarce. Here, we developed a foundation model for cancer imaging biomarker discovery by training a convolutional encoder through self-supervised learning using a comprehensive dataset of 11,467 radiographic lesions...
2024: Nature Machine Intelligence
#24
JOURNAL ARTICLE
Carla M Barcelo, Vasco Filipe, Mostafa Nakach, Maria Inês Ré
Spray drying is increasingly being applied to process biopharmaceuticals, particularly monoclonal antibodies (mAbs). However, due to their protein nature, mAbs are susceptible to degradation when subjected to various stresses during a drying process. Despite extensive research in this domain, identifying the appropriate formulation composition and spray drying conditions remains a complex challenge, requiring further studies to enhance the understanding on how process and formulation parameters impact mAb stability in reconstituted solutions...
March 20, 2024: International Journal of Pharmaceutics
#25
JOURNAL ARTICLE
Carla M Barcelo, Vasco Filipe, Mostafa Nakach, Maria Inês Ré
Despite extensive research in spray drying of biopharmaceuticals, identifying the optimal formulation composition and process conditions to minimize the various stresses a biopharmaceutical undergoes during this drying process. The current study extends previous research on investigating how spray drying processing and solution composition can affect the stability of monoclonal antibodies (mAbs) in reconstituted solutions for subcutaneous injections. The decoupling process stresses on a model mAb (mAb-A) compared to the effect of coupled spray-drying stresses revealed that excipients and protein concentration had a more pronounced effect on stabilizing mAb-A against shear and thermal/dehydration stresses than spray drying operating conditions...
March 19, 2024: International Journal of Pharmaceutics
#26
JOURNAL ARTICLE
Danillo Sales Rosa, Samily Aquino de Sá Oliveira, Renata de Faria Silva Souza, Chirles Araujo de França, Isabelle Caroline Pires, Márcio Rennan Santos Tavares, Helinando Pequeno de Oliveira, Fernando Antônio Gomes da Silva Júnior, Maria Aparecida Scatamburlo Moreira, Mariana de Barros, Gustavo Batista de Menezes, Maísa Mota Antunes, Vasco Ariston de Carvalho Azevedo, Carine Rosa Naue, Mateus Matiuzzi da Costa
INTRODUCTION: As a new promising therapeutic option, the activity of highly soluble polypyrrole (Hs-PPy), a specific formulation of a conducting polymer (polypyrrole - PPy) is evaluated against bacteria of clinical importance. AIMS: The purpose was to evaluate the antimicrobial activity of Hs-PPy, alone or combined with oxacillin, as well as its antibiofilm potential against methicillin-resistant Staphylococcus aureus strains. Furthermore, the in silico inhibitory mechanism in efflux pumps was also investigated...
March 19, 2024: Journal of Applied Microbiology
#27
JOURNAL ARTICLE
Cheyenne C E van Hagen, Anne J Huiberts, Elizabeth N Mutubuki, Hester E de Melker, Eric R A Vos, Janneke H H M van de Wijgert, Susan van den Hof, Mirjam J Knol, Albert Jan van Hoek
OBJECTIVES: We describe health-related quality of life during the COVID-19 pandemic in the general Dutch population and correlations with restrictive measures. METHODS: Data were obtained from 18-85 year-old participants of two population-based cohort studies (February 2021-July 2022): PIENTER Corona (n = 8,019) and VASCO (n = 45,413). Per cohort, mean scores of mental and physical health and health utility from the SF-12 were calculated by age group, sex and presence of a medical risk condition...
2024: PloS One
#28
REVIEW
Ana I Furtado, Vasco D B Bonifácio, Raquel Viveiros, Teresa Casimiro
The design and development of affinity polymeric materials through the use of green technology, such as supercritical carbon dioxide (scCO2 ), is a rapidly evolving field of research with vast applications across diverse areas, including analytical chemistry, pharmaceuticals, biomedicine, energy, food, and environmental remediation. These affinity polymeric materials are specifically engineered to interact with target molecules, demonstrating high affinity and selectivity. The unique properties of scCO2 , which present both liquid- and gas-like properties and an accessible critical point, offer an environmentally-friendly and highly efficient technology for the synthesis and processing of polymers...
February 20, 2024: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
#29
JOURNAL ARTICLE
Régis Pouillot, Andreas Kiermeier, Laurent Guillier, Vasco Cadavez, Moez Sanaa
Better knowledge regarding the Listeria monocytogenes dose-response (DR) model is needed to refine the assessment of the risk of foodborne listeriosis. In 2018, the European Food Safety Agency (EFSA) derived a lognormal Poisson DR model for 14 different age-sex sub-groups, marginally to strain virulence. In the present study, new sets of parameters are developed by integrating the EFSA model for these sub-groups together with three classes of strain virulence characteristics ("less virulent", "virulent", and "more virulent")...
February 29, 2024: Foods (Basel, Switzerland)
#30
REVIEW
Ursula Gonzales-Barron, Vasco Cadavez, Juliana De Oliveira Mota, Laurent Guillier, Moez Sanaa
Invasive listeriosis, due to its severe nature in susceptible populations, has been the focus of many quantitative risk assessment (QRA) models aiming to provide a valuable guide in future risk management efforts. A review of the published QRA models of Listeria monocytogenes in seafood was performed, with the objective of appraising the effectiveness of the control strategies at different points along the food chain. It is worth noting, however, that the outcomes of a QRA model are context-specific, and influenced by the country and target population, the assumptions that are employed, and the model architecture itself...
February 26, 2024: Foods (Basel, Switzerland)
#31
JOURNAL ARTICLE
Justin Wang, Vasco Deon Kidd, Brad Giafaglione, Brian Strong, Anuj Ohri, Janice White, Alpesh Amin
Introduction Patient experience is a crucial aspect of healthcare delivery, and it encompasses various elements that contribute to a patient's perception of the care they receive. Patient satisfaction and patient experience are related but distinct concepts. Patient experience focuses on whether specific aspects of care occurred, while patient satisfaction gauges whether patient expectations were met. It goes beyond mere satisfaction and delves into the broader aspects of how patients interact with the healthcare system and the quality of those interactions, with health plans, doctors, nurses, and staff in various healthcare facilities...
March 2024: Curēus
#32
JOURNAL ARTICLE
Júlio A Costa, Susana Vale, Rita Cordovil, Luís P Rodrigues, Vasco Cardoso, Rui Proença, Manuel Costa, Carlos Neto, João Brito, José Guilherme, André Seabra
OBJECTIVE: The "Super Quinas" project evaluated the effectiveness of an intervention program to improve physical activity, aerobic fitness, sleep, and motor competence on children in primary school. METHODS: The experimental group ( n = 19) enrolled in a 12-week intervention program (one more extra-curricular activity class of 60 min per week) compared to the CG ( n = 19), all aged 9-10 years. Physical activity (PA) and sleep were measured by accelerometry, and aerobic fitness was measured by Children's Yo-Yo test (YYIR1C) during the 1st week (PRE), the 6th week (DUR), and the 12th week (POST) of the intervention program...
2024: Frontiers in Public Health
#33
RANDOMIZED CONTROLLED TRIAL
Federico Biavati, Luca Saba, Melinda Boussoussou, Klaus F Kofoed, Theodora Benedek, Patrick Donnelly, José Rodríguez-Palomares, Andrejs Erglis, Cyril Štěchovský, Gintarė Šakalytė, Nada Čemerlić Ađić, Matthias Gutberlet, Jonathan D Dodd, Ignacio Diez, Gershan Davis, Elke Zimmermann, Cezary Kępka, Radosav Vidakovic, Marco Francone, Małgorzata Ilnicka-Suckiel, Fabian Plank, Juhani Knuuti, Rita Faria, Stephen Schröder, Colin Berry, Balazs Ruzsics, Nina Rieckmann, Christine Kubiak, Kristian Schultz Hansen, Jacqueline Müller-Nordhorn, Pál Maurovich-Horvat, Per E Sigvardsen, Imre Benedek, Clare Orr, Filipa Xavier Valente, Ligita Zvaigzne, Vojtěch Suchánek, Antanas Jankauskas, Filip Ađić, Michael Woinke, Diarmaid Cadogan, Iñigo Lecumberri, Erica Thwaite, Mariusz Kruk, Aleksandar N Neskovic, Massimo Mancone, Donata Kuśmierz, Gudrun Feuchtner, Mikko Pietilä, Vasco Gama Ribeiro, Tanja Drosch, Christian Delles, Riccardo Cau, Michael Fisher, Bela Merkely, Charlotte Kragelund, Rosca Aurelian, Stephanie Kelly, Bruno García Del Blanco, Ainhoa Rubio, Bálint Szilveszter, Jens D Hove, Ioana Rodean, Susan Regan, Hug Cuéllar Calabria, István Ferenc Édes, Linnea Larsen, Roxana Hodas, Adriane E Napp, Robert Haase, Sarah Feger, Mahmoud Mohamed, Lina M Serna-Higuita, Konrad Neumann, Henryk Dreger, Matthias Rief, Viktoria Wieske, Matthew J Budoff, Melanie Estrella, Peter Martus, Maria Bosserdt, Marc Dewey
Background Coronary artery calcium (CAC) has prognostic value for major adverse cardiovascular events (MACE) in asymptomatic individuals, whereas its role in symptomatic patients is less clear. Purpose To assess the prognostic value of CAC scoring for MACE in participants with stable chest pain initially referred for invasive coronary angiography (ICA). Materials and Methods This prespecified subgroup analysis from the Diagnostic Imaging Strategies for Patients With Stable Chest Pain and Intermediate Risk of Coronary Artery Disease (DISCHARGE) trial, conducted between October 2015 and April 2019 across 26 centers in 16 countries, focused on adult patients with stable chest pain referred for ICA...
March 2024: Radiology
#34
JOURNAL ARTICLE
Oppah Kuguyo, Doreen Macherera Mukona, Vasco Chikwasha, Lovemore Gwanzura, Joconiah Chirenda, Alice Matimba
BACKGROUND: Diabetic foot disease (DF) is a common diabetes-related complication; however, the prevalence and associated risk factors for DF are not well characterised among people living with diabetes (PLWD) in Zimbabwe. This may suggest the unavailability of adequate strategies to diagnose and treat DF in the country. This study aimed to determine the prevalence of DF and associated risk factors for PLWD in Harare, Zimbabwe. METHODS: This was a cross-sectional study, employing a quantitative approach...
March 4, 2024: BMC Public Health
#35
JOURNAL ARTICLE
Melanie Brugger, Antonella Lauri, Yan Zhen, Laura L Gramegna, Benedikt Zott, Nikolina Sekulić, Giulia Fasano, Robert Kopajtich, Viviana Cordeddu, Francesca Clementina Radio, Cecilia Mancini, Simone Pizzi, Graziamaria Paradisi, Ginevra Zanni, Gessica Vasco, Rosalba Carrozzo, Flavia Palombo, Caterina Tonon, Raffaele Lodi, Chiara La Morgia, Maria Arelin, Cristiane Blechschmidt, Tom Finck, Vigdis Sørensen, Kornelia Kreiser, Gertrud Strobl-Wildemann, Hagit Daum, Rachel Michaelson-Cohen, Lucia Ziccardi, Giuseppe Zampino, Holger Prokisch, Rami Abou Jamra, Claudio Fiorini, Thomas Arzberger, Juliane Winkelmann, Leonardo Caporali, Valerio Carelli, Harald Stenmark, Marco Tartaglia, Matias Wagner
The endosomal sorting complex required for transport (ESCRT) machinery is essential for membrane remodeling and autophagy and it comprises three multi-subunit complexes (ESCRT I-III). We report nine individuals from six families presenting with a spectrum of neurodevelopmental/neurodegenerative features caused by bi-allelic variants in SNF8 (GenBank: NM_007241.4), encoding the ESCRT-II subunit SNF8. The phenotypic spectrum included four individuals with severe developmental and epileptic encephalopathy, massive reduction of white matter, hypo-/aplasia of the corpus callosum, neurodevelopmental arrest, and early death...
February 21, 2024: American Journal of Human Genetics
#36
JOURNAL ARTICLE
Esau Simutowe, Hambulo Ngoma, Mark Manyanga, João Vasco Silva, Frédéric Baudron, Isaiah Nyagumbo, Kelvin Kalala, Mukwemba Habeenzu, Christian Thierfelder
Sustainable agricultural practices such as conservation agriculture have been promoted in southern Africa for nearly three decades, but their adoption remains low. It is of policy interest to unpack behavioural drivers of adoption to understand why adoption remains lower than anticipated. This paper assesses the effects of risk aversion and impatience on the extent and intensity of the adoption of conservation agriculture using panel data collected from 646 households in 2021 and 2022 in Zambia. We find that 12% and 18% of the smallholders were impatient and risk averse, respectively...
February 29, 2024: Heliyon
#37
JOURNAL ARTICLE
Maria Bosserdt, Lina M Serna-Higuita, Gudrun Feuchtner, Bela Merkely, Klaus F Kofoed, Theodora Benedek, Patrick Donnelly, José Rodriguez-Palomares, Andrejs Erglis, Cyril Štechovský, Gintare Šakalyte, Nada Cemerlic Adic, Matthias Gutberlet, Jonathan D Dodd, Ignacio Diez, Gershan Davis, Elke Zimmermann, Cezary Kepka, Radosav Vidakovic, Marco Francone, Malgorzata Ilnicka-Suckiel, Fabian Plank, Juhani Knuuti, Rita Faria, Stephen Schröder, Colin Berry, Luca Saba, Balazs Ruzsics, Nina Rieckmann, Christine Kubiak, Kristian Schultz Hansen, Jacqueline Müller-Nordhorn, Bálint Szilveszter, Per E Sigvardsen, Imre Benedek, Clare Orr, Filipa Xavier Valente, Ligita Zvaigzne, Vojtech Suchánek, Antanas Jankauskas, Filip Adic, Michael Woinke, Mark Hensey, Iñigo Lecumberri, Erica Thwaite, Michael Laule, Mariusz Kruk, Aleksandar N Neskovic, Massimo Mancone, Donata Kusmierz, Mikko Pietilä, Vasco Gama Ribeiro, Tanja Drosch, Christian Delles, Maurizio Porcu, Michael Fisher, Melinda Boussoussou, Charlotte Kragelund, Rosca Aurelian, Stephanie Kelly, Bruno Garcia Del Blanco, Ainhoa Rubio, Pál Maurovich-Horvat, Jens D Hove, Ioana Rodean, Susan Regan, Hug Cuellar-Calabria, Levente Molnár, Linnea Larsen, Roxana Hodas, Adriane E Napp, Robert Haase, Sarah Feger, Mahmoud Mohamed, Konrad Neumann, Henryk Dreger, Matthias Rief, Viktoria Wieske, Melanie Estrella, Peter Martus, Harold C Sox, Marc Dewey
IMPORTANCE: The effectiveness and safety of computed tomography (CT) and invasive coronary angiography (ICA) in different age groups is unknown. OBJECTIVE: To determine the association of age with outcomes of CT and ICA in patients with stable chest pain. DESIGN, SETTING, AND PARTICIPANTS: The assessor-blinded Diagnostic Imaging Strategies for Patients With Stable Chest Pain and Intermediate Risk of Coronary Artery Disease (DISCHARGE) randomized clinical trial was conducted between October 2015 and April 2019 in 26 European centers...
February 28, 2024: JAMA Cardiology
#38
JOURNAL ARTICLE
Mohamed A Raslan, Sara A Raslan, Eslam M Shehata, Amr S Mahmoud, Marcus Vinicius Canário Viana, Debmalya Barh, Nagwa A Sabri, Vasco Azevedo
Proteomics has grown in importance in molecular sciences because it gives vital information on protein identification, expression levels, and alteration. Cancer is one of the world's major causes of death and is the major focus of much research. Cancer risk is determined by hereditary variables as well as the body's immunological condition. Probiotics have increasing medical importance due to their therapeutic influence on the human body in the prevention and treatment of numerous chronic illnesses, including cancer, with no adverse effects...
2024: Advances in Experimental Medicine and Biology
#39
JOURNAL ARTICLE
Mohamed A Raslan, Sara A Raslan, Eslam M Shehata, Amr S Mahmoud, Marcus Vinicius Canário Viana, Flávia Aburjaile, Debmalya Barh, Nagwa A Sabri, Vasco Azevedo
Microbiotas are an adaptable component of ecosystems, including human ecology. Microorganisms influence the chemistry of their specialized niche, such as the human gut, as well as the chemistry of distant surroundings, such as other areas of the body. Metabolomics based on mass spectrometry (MS) is one of the primary methods for detecting and identifying small compounds generated by the human microbiota, as well as understanding the functional significance of these microbial metabolites. This book chapter gives basic knowledge on the kinds of untargeted mass spectrometry as well as the data types that may be generated in the context of microbiome study...
2024: Advances in Experimental Medicine and Biology
#40
JOURNAL ARTICLE
Marco Antonio Catussi Paschoalotto, Joana Cima, Eduardo Costa, Sara Valente de Almeida, Joana Gomes da Costa, João Vasco Santos, Claudia Souza Passador, João Luiz Passador, Pedro Pita Barros
This study has the aim of assessing the Brazilian perceptions, influencing factors and political positioning on the confidence concerning COVID-19 vaccination. To achieve the objective, the methods rely on a cross-sectional survey of Brazilian citizens, distributed through different social networks. The sample is composed of 1,670 valid responses, collected from almost all Brazilian states and state capitals. To analyze the data and give a clear view of the variables' relationship, the study used bivariate and comparative graphs...
December 31, 2024: Human Vaccines & Immunotherapeutics
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