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https://www.readbyqxmd.com/read/28651292/acute-onset-neurological-disorders-during-pregnancy-a-literature-review
#1
Zita Ferraz, Joana Parra, Ana Luísa Areia, Elsa Vasco, Paulo Moura
Objectives To characterize the most common peripheral and central neurological disorders during pregnancy. Methods Original research and review of the literature on neurological complications during pregnancy. We searched for keywords related to the topic on different databases. Results Pregnancy involves physiological changes that can trigger peripheral neurological and/or central nervous system pathologies, which can sometimes be associated with hypertensive disorders. A definitive diagnosis of neurological disorders can be made according to the trimester of pregnancy and the clinical findings...
June 26, 2017: Revista Brasileira de Ginecologia e Obstetrícia
https://www.readbyqxmd.com/read/28642747/propionibacterium-freudenreichii-surface-protein-slpb-is-involved-in-adhesion-to-intestinal-ht-29-cells
#2
Fillipe L R do Carmo, Houem Rabah, Song Huang, Floriane Gaucher, Martine Deplanche, Stéphanie Dutertre, Julien Jardin, Yves Le Loir, Vasco Azevedo, Gwénaël Jan
Propionibacterium freudenreichii is a beneficial bacterium traditionally used as a cheese ripening starter and more recently for its probiotic abilities based on the release of beneficial metabolites. In addition to these metabolites (short-chain fatty acids, vitamins, and bifidogenic factor), P. freudenreichii revealed an immunomodulatory effect confirmed in vivo by the ability to protect mice from induced acute colitis. This effect is, however, highly strain-dependent. Local action of metabolites and of immunomodulatory molecules is favored by the ability of probiotics to adhere to the host cells...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28639137/the-frank-starling-law-a-jigsaw-of-titin-proportions
#3
REVIEW
Vasco Sequeira, Jolanda van der Velden
The Frank-Starling Law dictates that the heart is able to match ejection to the dynamic changes occurring during cardiac filling, hence efficiently regulating isovolumetric contraction and shortening. In the last four decades, efforts have been made to identify a common fundamental basis for the Frank-Starling heart that can explain the direct relationship between muscle lengthening and its increased sensitization to Ca(2+). The term 'myofilament length-dependent activation' describes the length-dependent properties of the myofilaments, but what is(are) the underlying molecular mechanism(s) is a matter of ongoing debate...
June 21, 2017: Biophysical Reviews
https://www.readbyqxmd.com/read/28631870/thalamic-deep-brain-stimulation-for-neuropathic-pain-efficacy-at-three-years-follow-up
#4
Vasco Abreu, Rui Vaz, Virgínia Rebelo, Maria José Rosas, Clara Chamadoira, Martin J Gillies, Tipu Z Aziz, Erlick A C Pereira
OBJECT: Chronic neuropathic pain is estimated to affect 3-4.5% of the worldwide population, posing a serious burden to society. Deep Brain Stimulation (DBS) is already established for movement disorders and also used to treat some "off-label" conditions. However, DBS for the treatment of chronic, drug refractory, neuropathic pain, has shown variable outcomes with few studies performed in the last decade. Thus, this procedure has consensus approval in parts of Europe but not the USA. This study prospectively evaluated the efficacy at three years of DBS for neuropathic pain...
June 20, 2017: Neuromodulation: Journal of the International Neuromodulation Society
https://www.readbyqxmd.com/read/28623263/probing-spermiogenesis-a-digital-strategy-for-mouse-acrosome-classification
#5
Alessandro Taloni, Francesc Font-Clos, Luca Guidetti, Simone Milan, Miriam Ascagni, Chiara Vasco, Maria Enrica Pasini, Maria Rosa Gioria, Emilio Ciusani, Stefano Zapperi, Caterina A M La Porta
Classification of morphological features in biological samples is usually performed by a trained eye but the increasing amount of available digital images calls for semi-automatic classification techniques. Here we explore this possibility in the context of acrosome morphological analysis during spermiogenesis. Our method combines feature extraction from three dimensional reconstruction of confocal images with principal component analysis and machine learning. The method could be particularly useful in cases where the amount of data does not allow for a direct inspection by trained eye...
June 16, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28619055/molecular-typing-of-leptospira-interrogans-serovar-hardjo-isolates-from-leptospirosis-outbreaks-in-brazilian-livestock
#6
Maria Raquel V Cosate, Tetsu Sakamoto, Tiago Antônio de Oliveira Mendes, Élvio C Moreira, Carlos G Regis da Silva, Bruno S A F Brasil, Camila S F Oliveira, Vasco Ariston de Azevedo, José Miguel Ortega, Rômulo C Leite, João Paulo Haddad
BACKGROUND: Leptospirosis is caused by pathogenic spirochetes of the genus Leptospira spp. This zoonotic disease is distributed globally and affects domestic animals, including cattle. Leptospira interrogans serogroup Sejroe serovar Hardjo and Leptospira borgpetersenii serogroup Sejroe serovar Hardjo remain important species associated with this reproductive disease in livestock production. Previous studies on Brazilian livestock have reported that L. interrogans serovar Hardjo is the most prevalent leptospiral agent in this country and is related to clinical signs of leptospirosis, which lead to economic losses in production...
June 15, 2017: BMC Veterinary Research
https://www.readbyqxmd.com/read/28600984/impaired-cross-talk-between-the-thioredoxin-and-glutathione-systems-is-related-to-ask-1-mediated-apoptosis-in-neuronal-cells-exposed-to-mercury
#7
Vasco Branco, Lucia Coppo, Susana Solá, Jun Lu, Cecília M P Rodrigues, Arne Holmgren, Cristina Carvalho
Mercury (Hg) compounds target both cysteine (Cys) and selenocysteine (Sec) residues in peptides and proteins. Thus, the components of the two major cellular antioxidant systems - glutathione (GSH) and thioredoxin (Trx) systems - are likely targets for mercurials. Hg exposure results in GSH depletion and Trx and thioredoxin reductase (TrxR) are prime targets for mercury. These systems have a wide-range of common functions and interaction between their components has been reported. However, toxic effects over both systems are normally treated as isolated events...
June 1, 2017: Redox Biology
https://www.readbyqxmd.com/read/28595597/label-free-quantitative-proteomics-of-corynebacterium-pseudotuberculosis-isolates-reveals-differences-between-biovars-ovis-and-equi-strains
#8
Wanderson M Silva, Edson L Folador, Siomar C Soares, Gustavo H M F Souza, Agenor V Santos, Cassiana S Sousa, Henrique Figueiredo, Anderson Miyoshi, Yves Le Loir, Artur Silva, Vasco Azevedo
No abstract text is available yet for this article.
June 8, 2017: BMC Genomics
https://www.readbyqxmd.com/read/28589102/heterogeneous-family-of-cyclomodulins-smart-weapons-that-allow-bacteria-to-hijack-the-eukaryotic-cell-cycle-and-promote-infections
#9
REVIEW
Rachid A El-Aouar Filho, Aurélie Nicolas, Thiago L De Paula Castro, Martine Deplanche, Vasco A De Carvalho Azevedo, Pierre L Goossens, Frédéric Taieb, Gerard Lina, Yves Le Loir, Nadia Berkova
Some bacterial pathogens modulate signaling pathways of eukaryotic cells in order to subvert the host response for their own benefit, leading to successful colonization and invasion. Pathogenic bacteria produce multiple compounds that generate favorable conditions to their survival and growth during infection in eukaryotic hosts. Many bacterial toxins can alter the cell cycle progression of host cells, impairing essential cellular functions and impeding host cell division. This review summarizes current knowledge regarding cyclomodulins, a heterogeneous family of bacterial effectors that induce eukaryotic cell cycle alterations...
2017: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/28587680/in-vitro-antineoplastic-effects-of-brivaracetam-and-lacosamide-on-human-glioma-cells
#10
Ambra Rizzo, Sara Donzelli, Vita Girgenti, Andrea Sacconi, Chiara Vasco, Andrea Salmaggi, Giovanni Blandino, Marta Maschio, Emilio Ciusani
BACKGROUND: Epilepsy is a frequent symptom in patients with glioma. Although treatment with antiepileptic drugs is generally effective in controlling seizures, drug-resistant patients are not uncommon. Multidrug resistance proteins (MRPs) and P-gp are over-represented in brain tissue of patients with drug-resistant epilepsy, suggesting their involvement in the clearance of antiepileptic medications. In addition to their anticonvulsant action, some drugs have been documented for cytotoxic effects...
June 6, 2017: Journal of Experimental & Clinical Cancer Research: CR
https://www.readbyqxmd.com/read/28579977/in-silico-prediction-in-vitro-antibacterial-spectrum-and-physicochemical-properties-of-a-putative-bacteriocin-produced-by-lactobacillus-rhamnosus-strain-l156-4
#11
Letícia de C Oliveira, Aline M M Silveira, Andréa de S Monteiro, Vera L Dos Santos, Jacques R Nicoli, Vasco A de C Azevedo, Siomar de C Soares, Marcus V Dias-Souza, Regina M D Nardi
A bacteriocinogenic Lactobacillus rhamnosus L156.4 strain isolated from the feces of NIH mice was identified by 16S rRNA gene sequencing and MALDI-TOF mass spectrometry. The entire genome was sequenced using Illumina, annotated in the PGAAP, and RAST servers, and deposited. Conserved genes associated with bacteriocin synthesis were predicted using BAGEL3, leading to the identification of an open reading frame (ORF) that shows homology with the L. rhamnosus GG (ATCC 53103) prebacteriocin gene. The encoded protein contains a conserved protein motif associated a structural gene of the Enterocin A superfamily...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28576591/large-thrombus-formation-on-an-amplatzer%C3%A2-cardiac-plug
#12
Ana Isabel Azevedo, Lino Santos, José Ribeiro, Francisco Sampaio, Adelaide Dias, Vasco Gama Ribeiro
No abstract text is available yet for this article.
May 30, 2017: Portuguese Journal of Cardiology: An Official Journal of the Portuguese Society of Cardiology
https://www.readbyqxmd.com/read/28556850/clinical-profile-management-and-outcomes-of-patients-with-pulmonary-embolism-a-retrospective-tertiary-centre-study-in-angola
#13
Ana Manuel, Adelina Aufico, Rui Africano, Tomáz Peralta, Abel Salas, Adelaide Silva, José Ricardo, Pedro Sabola, Domingas Baião, Carlos Sotolongo, António Dias Neto, Telmo Martins, Vasco Sabino, Joaquim van Dúnem, António Pedro Filipe Júnior
OBJECTIVE: Pulmonary embolism (PE) is a potentially fatal disease. In Angola, few data are available on its occurrence. The aim of the study was to characterise the clinical profile, management and outcomes of patients with PE. METHODS: A retrospective observational study was conducted at the Girassol Clinic in Luanda, Angola. The medical records of patients admitted to the intensive care unit were analysed from 2011 to 2015. RESULTS: Fifty patients were included and the median age was 50...
May 17, 2017: Cardiovascular Journal of Africa
https://www.readbyqxmd.com/read/28555612/development-of-an-advanced-radioactive-airborne-particle-monitoring-system-to-use-in-early-warning-networks
#14
A Baeza, Jose Angel Corbacho, José Manuel Caballero, María Ángeles Ontalba, José Vasco, David Valencia
Automatic real-time warning networks are essential for the almost immediate detection of anomalous levels of radioactivity in the environment. In the case of Extremadura region (SW Spain), a radiological network (RARE) has been operational in the vicinity of the Almaraz nuclear power plant and in other areas farther away since 1992. There are ten air monitoring stations equipped with Geiger-Müller counters in order to evaluate the external ambient gamma dose rate. Four of those stations have a commercial system that provides estimates of the total artificial alpha and beta activity concentrations in aerosols and the 131 I activity (gaseous fraction)...
May 30, 2017: Journal of Radiological Protection: Official Journal of the Society for Radiological Protection
https://www.readbyqxmd.com/read/28538774/influence-of-the-ventilatory-mode-on-acute-adverse-effects-and-facial-thermography-after-noninvasive-ventilation
#15
Suzy Maria Montenegro Pontes, Luiz Henrique de Paula Melo, Nathalia Parente de Sousa Maia, Andrea da Nóbrega Cirino Nogueira, Thiago Brasileiro Vasconcelos, Eanes Delgado Barros Pereira, Vasco Pinheiro Diógenes Bastos, Marcelo Alcantara Holanda
Objective: To compare the incidence and intensity of acute adverse effects and the variation in the temperature of facial skin by thermography after the use of noninvasive ventilation (NIV). Methods: We included 20 healthy volunteers receiving NIV via oronasal mask for 1 h. The volunteers were randomly divided into two groups according to the ventilatory mode: bilevel positive airway pressure (BiPAP) or continuous positive airway pressure (CPAP). Facial thermography was performed in order to determine the temperature of the face where it was in contact with the mask and of the nasal dorsum at various time points...
March 2017: Jornal Brasileiro de Pneumologia: Publicaça̋o Oficial da Sociedade Brasileira de Pneumologia e Tisilogia
https://www.readbyqxmd.com/read/28536562/use-of-wild-type-or-recombinant-lactic-acid-bacteria-as-an-alternative-treatment-for-gastrointestinal-inflammatory-diseases-a-focus-on-inflammatory-bowel-diseases-and-mucositis
#16
REVIEW
Rodrigo D De Oliveira Carvalho, Fillipe L R do Carmo, Alberto de Oliveira Junior, Philippe Langella, Jean-Marc Chatel, Luis G Bermúdez-Humarán, Vasco Azevedo, Marcela S de Azevedo
The human gastrointestinal tract (GIT) is highly colonized by bacterial communities, which live in a symbiotic relationship with the host in normal conditions. It has been shown that a dysfunctional interaction between the intestinal microbiota and the host immune system, known as dysbiosis, is a very important factor responsible for the development of different inflammatory conditions of the GIT, such as the idiopathic inflammatory bowel diseases (IBD), a complex and multifactorial disorder of the GIT. Dysbiosis has also been implicated in the pathogenesis of other GIT inflammatory diseases such as mucositis usually caused as an adverse effect of chemotherapy...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28527479/-biliary-anastomosis-in-liver-transplantation-with-or-without-t-tube
#17
Janine Carmelino, Susana Rodrigues, Hugo Pinto Marques, Vasco Ribeiro, Daniel Virella, Marta Alves, Américo Martins, Eduardo Barroso
INTRODUCTION: Biliary complications occur in 10-30% of liver transplants. The aim of this study was to compare the incidence of these complications in liver transplants when the T-tube was or was not used during the biliary anastomosis. MATERIAL AND METHODS: Analysis of 2 groups of patients undergoing liver transplantation between 2008 and 2012. Patients were divided considering if the T-tube was used (G1) or if it was not (G2). We sought explanatory models of the occurrence of biliary complications by logistic regression, including the variables identified in the univariate analysis...
February 27, 2017: Acta Médica Portuguesa
https://www.readbyqxmd.com/read/28517046/three-dimensional-proximal-flow-convergence-automatic-calculation-for-determining-mitral-valve-area-in-rheumatic-mitral-stenosis
#18
Francisco Sampaio, Ricardo Ladeiras-Lopes, João Almeida, Paulo Fonseca, Ricardo Fontes-Carvalho, José Ribeiro, Vasco Gama
PURPOSE: Management of patients with mitral stenosis (MS) depends heavily on the accurate quantification of mitral valve area (MVA) using echocardiography. All currently used two-dimensional (2D) methods have limitations. Estimation of MVA using the proximal isovelocity surface area (PISA) method with real time three-dimensional (3D) echocardiography may circumvent those limitations. We aimed to evaluate the accuracy of 3D direct measurement of PISA in the estimation of MVA. METHODS: Twenty-seven consecutive patients (median age of 63 years; 77...
May 18, 2017: Echocardiography
https://www.readbyqxmd.com/read/28516859/recombinant-esterase-from-corynebacterium-pseudotuberculosis-in-dna-and-subunit-recombinant-vaccines-partially-protects-mice-against-challenge
#19
Alexandre Antunes Brum, Andrea de Fatima Silva Rezende, Francisco Silvestre Brilhante, Thais Collares, Karine Begnine, Fabiana Kommling Seixas, Tiago Veiras Collares, Odir Antônio Dellagostin, Vasco Azevedo, Anderson Santos, Ricardo Wagner Portela, Sibele Borsuk
PURPOSE: We tested the efficacy of the esterase encoded by cp1002_RS09720 from Corynebacteriumpseudotuberculosis in recombinant subunit and DNA caseous lymphadenitis (CLA) vaccines. This target was predicted as one of the best CLA vaccine candidates by mature epitope density analysis. METHODOLOGY: Gene cp1002_RS09720 was cloned into two different vectors (pAE for subunit vaccine and pTARGET for DNA vaccine). Four groups of 15 mice each were immunized with the recombinant esterase rCP09720 associated with aluminium hydroxide adjuvant (G1), pTARGET/cp09720 DNA vaccine (G2), a naked pTARGET (G3) or PBS as a negative control (G4)...
May 2017: Journal of Medical Microbiology
https://www.readbyqxmd.com/read/28505761/dispersive-transport-and-symmetry-of-the-dispersion-tensor-in-porous-media
#20
Steven R Pride, Donald W Vasco, Eirik G Flekkoy, Ran Holtzman
The macroscopic laws controlling the advection and diffusion of solute at the scale of the porous continuum are derived in a general manner that does not place limitations on the geometry and time evolution of the pore space. Special focus is given to the definition and symmetry of the dispersion tensor that is controlling how a solute plume spreads out. We show that the dispersion tensor is not symmetric and that the asymmetry derives from the advective derivative in the pore-scale advection-diffusion equation...
April 2017: Physical Review. E
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