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Camilo Andres Villabona, Marco Antônio Amorin Vasco, Edwin Ruales, Karin Apaza Bedoya, Cesar Magalhães Benfatti, Osvaldo Luis Bezzon, Tatiana Miranda Deliberador
Zirconia has been presented as an alternative biomaterial to titanium, commercially presented as a single body implant and / or as an abutment, demonstrating clinically biocompatible favorable results in white and rose aesthetics, However, the amount of long-term in-vivo studies and mechanical tests evaluating the response of stress distribution compared with titanium implants are still limited. The aim of the study was to compare by the finite element method, the principal stresses peaks in the peri implantar bone around titanium and zirconia implants...
May 15, 2018: Journal of Oral Implantology
Karen Silva Leal, Mara Thais de Oliveira Silva, Andréa de Fátima Silva Rezende, Francisco Silvestre Brilhante Bezerra, Karine Begnini, Fabiana Seixas, Tiago Collares, Odir Dellagostin, Ricardo Wagner Portela, Vasco Ariston de Carvalho Azevedo, Sibele Borsuk
The aim of this study was to evaluate the survival of mice inoculated with M. bovis BCG Pasteur recombinant expressing the PLD protein and challenged with a C. pseudotuberculosis virulent strain. Four groups were immunized with a sterile 0.9% saline solution (G1), 106  CFU of M. bovis BCG Pasteur (G2), 106  CFU of M. bovis BCG/pld (G3) or 106  CFU of M. bovis BCG/pld with a booster with rPLD (G4) and challenged with 104 CFU of C. pseudotuberculosis MIC-6 strain. The highest survival rate of 88% was observed in G4, followed by 77% in G3 and 66% in G2...
May 11, 2018: Vaccine
Julia K Nuy, Anja Lange, Arne J Beermann, Manfred Jensen, Vasco Elbrecht, Oliver Röhl, Derek Peršoh, Dominik Begerow, Florian Leese, Jens Boenigk
Stream ecosystems are affected by multiple anthropogenic stressors worldwide. Even though effects of many single stressors are comparatively well studied, the effects of multiple stressors are difficult to predict. In particular bacteria and protists, which are responsible for the majority of ecosystem respiration and element flows, are infrequently studied with respect to multiple stressors responses. We conducted a stream mesocosm experiment to characterize the responses of single and multiple stressors on microbiota...
August 15, 2018: Science of the Total Environment
José R López-Mínguez, Juan M Nogales-Asensio, Eduardo Infante De Oliveira, Vasco De Gama Ribeiro, Rafael Ruiz-Salmerón, Dabit Arzamendi-Aizpurua, Marco Costa, Hipólito Gutiérrez-García, José Antonio Fernández-Díaz, Victoria Martín-Yuste, Juan Carlos Rama-Merchán, Raúl Moreno-Gómez, Amparo Benedicto-Buendía, Andrés Íñiguez-Romo
INTRODUCTION AND OBJECTIVES: Many patients with nonvalvular atrial fibrillation are still left without protection due to a contraindication for anticoagulants. This study aimed to establish the occurrence of stroke and major bleeding events in patients with nonvalvular atrial fibrillation and left atrial appendage closure with long-term follow-up and to explore the factors associated with higher long-term mortality. METHODS: Analysis of a multicenter single cohort prospectively recruited from 2009 to 2015...
May 10, 2018: Revista Española de Cardiología
André S Santos, Rommel T Ramos, Artur Silva, Raphael Hirata, Ana L Mattos-Guaraldi, Roberto Meyer, Vasco Azevedo, Liza Felicori, Luis G C Pacheco
Biochemical tests are traditionally used for bacterial identification at the species level in clinical microbiology laboratories. While biochemical profiles are generally efficient for the identification of the most important corynebacterial pathogen Corynebacterium diphtheriae, their ability to differentiate between biovars of this bacterium is still controversial. Besides, the unambiguous identification of emerging human pathogenic species of the genus Corynebacterium may be hampered by highly variable biochemical profiles commonly reported for these species, including Corynebacterium striatum, Corynebacterium amycolatum, Corynebacterium minutissimum, and Corynebacterium xerosis...
May 11, 2018: Functional & Integrative Genomics
Andiara Gonçalves-Tenório, Beatriz Nunes Silva, Vânia Rodrigues, Vasco Cadavez, Ursula Gonzales-Barron
The objective of this study was to investigate and summarize the levels of incidence of Salmonella spp., Listeria monocytogenes , Staphylococcus aureus and Campylobacter spp. in poultry meat commercialized in Europe. After systematic review, incidence data and study characteristics were extracted from 78 studies conducted in 21 European countries. Pooled prevalence values from 203 extracted observations were estimated from random-effects meta-analysis models adjusted by pathogen, poultry type, sampling stage, cold preservation type, meat cutting type and packaging status...
May 3, 2018: Foods (Basel, Switzerland)
Vasco Vanhala, Antti Junkkari, Ville E Korhonen, Mitja I Kurki, Mikko Hiltunen, Tuomas Rauramaa, Ossi Nerg, Anne M Koivisto, Anne M Remes, Jonna Perälä, Jaana Suvisaari, Soili M Lehto, Heimo Viinamäki, Hilkka Soininen, Juha E Jääskeläinen, Ville Leinonen
BACKGROUND: Idiopathic normal pressure hydrocephalus (iNPH) is a progressive and potentially treatable neurodegenerative disease affecting elderly people, characterized by gait impairment and ventricular enlargement in brain imaging. Similar findings are seen in some patients with schizophrenia (SCZ). OBJECTIVE: To determine the prevalence of SCZ among patients suffering from probable or possible iNPH and the specific effects of comorbid SCZ on the outcome of the cerebrospinal fluid (CSF) shunting...
May 8, 2018: Neurosurgery
Filipe Veloso Gomes, João A Oliveira, Mariana Tomé Correia, Nuno Vasco Costa, João Abrantes, Daniel Torres, Pedro Pereira, Ana Isabel Ferreira, José Hugo Luz, Erik Spaepen, Tiago Bilhim, Élia Coimbra
PURPOSE: To evaluate the efficacy and safety of transarterial chemoembolization with polyethylene glycol (PEG) drug-eluting embolic agents in the treatment of hepatocellular carcinoma (HCC). MATERIALS AND METHODS: A single-center retrospective study of 302 patients (258 men; 85.4%) with HCC treated during a 20-month period was conducted. The mean patient age was 66 years ± 10; 142 (47%) had Barcelona Clinic Liver Cancer stage A disease and 134 had (44.4%) stage B disease; 174 (57...
April 30, 2018: Journal of Vascular and Interventional Radiology: JVIR
Tuuli A Nissinen, Jaakko Hentilä, Fabio Penna, Anita Lampinen, Juulia H Lautaoja, Vasco Fachada, Tanja Holopainen, Olli Ritvos, Riikka Kivelä, Juha J Hulmi
BACKGROUND: Cancer cachexia increases morbidity and mortality, and blocking of activin receptor ligands has improved survival in experimental cancer. However, the underlying mechanisms have not yet been fully uncovered. METHODS: The effects of blocking activin receptor type 2 (ACVR2) ligands on both muscle and non-muscle tissues were investigated in a preclinical model of cancer cachexia using a recombinant soluble ACVR2B (sACVR2B-Fc). Treatment with sACVR2B-Fc was applied either only before the tumour formation or with continued treatment both before and after tumour formation...
May 2, 2018: Journal of Cachexia, Sarcopenia and Muscle
Yanira Méndez, Janoi Chang, Ana R Humpierre, Abel Zanuy, Raine Garrido, Aldrin V Vasco, Jessy Pedroso, Darielys Santana, Laura M Rodríguez, Dagmar García-Rivera, Yury Valdés, Vicente Vérez-Bencomo, Daniel G Rivera
A new synthetic strategy for the development of multivalent antibacterial glycoconjugate vaccines is described. The approach comprises the utilization of an isocyanide-based multicomponent process for the conjugation of functionalized capsular polysaccharides of S. pneumoniae and S. Typhi to carrier proteins such as diphtheria and tetanus toxoids. For the first time, oxo- and carboxylic acid-functionalized polysaccharides could be either independently or simultaneously conjugated to immunogenic proteins by means of the Ugi-multicomponent reaction, thus leading to mono- or multivalent unimolecular glycoconjugates as vaccine candidates...
March 7, 2018: Chemical Science
Ana Serra Silva, Maria Pitta Groz, Paula Leandro, Carlos A Assis, Rui Figueira
The collection of the Museu Oceanográfico D. Carlos I is a historical specimen, instrument, and document collection that has been housed at the Aquário Vasco da Gama since 1935. The collection is largely the result of several scientific campaigns conducted by Dom Carlos de Bragança between 1896 and 1907. Specifically, the ichthyological collection consists of 675 surviving catalogue records of specimens caught, acquired or offered to D. Carlos I between 1892 to 1907, and includes the type specimen for Odontaspis nasutus Bragança, 1904 (junior synonym of Mitsukurina owstoni Jordan, 1898), along with several specimens of deep sea species...
2018: ZooKeys
Hélder Pereira, Daniel Caldeira, Rui Campante Teles, Marco Costa, Pedro Canas da Silva, Vasco da Gama Ribeiro, Vítor Brandão, Dinis Martins, Fernando Matias, Francisco Pereira-Machado, José Baptista, Pedro Farto E Abreu, Ricardo Santos, António Drummond, Henrique Cyrne de Carvalho, João Calisto, João Carlos Silva, João Luís Pipa, Jorge Marques, Paulino Sousa, Renato Fernandes, Rui Cruz Ferreira, Sousa Ramos, Eduardo Infante Oliveira, Manuel de Sousa Almeida
BACKGROUND: We aimed to evaluate the impact of thrombus aspiration (TA) during primary percutaneous coronary intervention (P-PCI) in 'real-world' settings. METHODS: We performed a retrospective study, using data from the National Registry of Interventional Cardiology (RNCI 2006-2012, Portugal) with ST-elevation myocardial infarction (STEMI) patients treated with P-PCI. The primary outcome, in-hospital mortality, was analysed through adjusted odds ratio (aOR) and 95% confidence intervals (95%CI)...
April 24, 2018: BMC Cardiovascular Disorders
João Rafael de Oliveira Dias, Camila V Ventura, Bruno de Paula Freitas, Juliana Prazeres, Liana O Ventura, Vasco Bravo-Filho, Tomas Aleman, Albert Icksang Ko, Andréa Zin, Rubens Belfort, Mauricio Maia
Zika virus (ZIKV) is an arbovirus mainly transmitted to humans by mosquitoes from Aedes genus. Other ways of transmission include the perinatal and sexual routes, blood transfusion, and laboratory exposure. Although the first human cases were registered in 1952 in African countries, outbreaks were only reported since 2007, when entire Pacific islands were affected. In March 2015, the first cases of ZIKV acute infection were notified in Brazil and, to date, 48 countries and territories in the Americas have confirmed local mosquito-borne transmission of ZIKV...
April 23, 2018: Progress in Retinal and Eye Research
Catarina Ruivo, José Ribeiro, Alberto Rodrigues, Luís Vouga, Vasco Gama
No abstract text is available yet for this article.
March 2018: Arquivos Brasileiros de Cardiologia
Lorena Travaglini, Chiara Aiello, Fabrizia Stregapede, Adele D'Amico, Viola Alesi, Andrea Ciolfi, Alessandro Bruselles, Michela Catteruccia, Simone Pizzi, Ginevra Zanni, Sara Loddo, Sabina Barresi, Gessica Vasco, Marco Tartaglia, Enrico Bertini, Francesco Nicita
Hereditary spastic paraplegias (HSP) are clinical and genetic heterogeneous diseases with more than 80 disease genes identified thus far. Studies on large cohorts of HSP patients showed that, by means of current technologies, the percentage of genetically solved cases is close to 50%. Notably, the percentage of molecularly confirmed diagnoses decreases significantly in sporadic patients. To describe our diagnostic molecular genetic approach on patients with pediatric-onset pure and complex HSP, 47 subjects with HSP underwent molecular screening of 113 known and candidate disease genes by targeted capture and massively parallel sequencing...
April 24, 2018: Neurogenetics
Robert Hemke, Vasco Mascarenhas, Mario Maas
Since the introduction of new MR imaging techniques within the past two decades, the imaging assessment of joints in rheumatic diseases has changed considerably. MRI enables to evaluate both the inflamed synovial membrane as well as early structural damage. In the last few years, several new functional/metabolic MR imaging techniques have applied in rheumatic diseases, making it possible to evaluate the pathophysiology of the disease in greater detail. Moreover, they permit a more quantitative approach for the evaluation of disease activity and damage...
April 2018: Seminars in Musculoskeletal Radiology
Fillipe L R do Carmo, Houem Rabah, Rodrigo D De Oliveira Carvalho, Floriane Gaucher, Barbara F Cordeiro, Sara H da Silva, Yves Le Loir, Vasco Azevedo, Gwénaël Jan
Some Gram-positive bacteria, including probiotic ones, are covered with an external proteinaceous layer called a surface-layer. Described as a paracrystalline layer and formed by the self-assembly of a surface-layer-protein (Slp), this optional structure is peculiar. The surface layer per se is conserved and encountered in many prokaryotes. However, the sequence of the corresponding Slp protein is highly variable among bacterial species, or even among strains of the same species. Other proteins, including surface layer associated proteins (SLAPs), and other non-covalently surface-bound proteins may also be extracted with this surface structure...
2018: Frontiers in Microbiology
Vasco Elbrecht, Ecaterina Edith Vamos, Dirk Steinke, Florian Leese
Background: DNA metabarcoding is used to generate species composition data for entire communities. However, sequencing errors in high-throughput sequencing instruments are fairly common, usually requiring reads to be clustered into operational taxonomic units (OTUs), losing information on intraspecific diversity in the process. While Cytochrome c oxidase subunit I (COI) haplotype information is limited in resolving intraspecific diversity it is nevertheless often useful e.g. in a phylogeographic context, helping to formulate hypotheses on taxon distribution and dispersal...
2018: PeerJ
Xavier Corbella, Vasco Barreto, Stefano Bassetti, Monica Bivol, Pietro Castellino, Evert-Jan de Kruijf, Francesco Dentali, Mine Durusu-Tanriöver, Carmen Fierbinţeanu-Braticevici, Thomas Hanslik, Radovan Hojs, Soňa Kiňová, Leonid Lazebnik, Evija Livčāne, Matthias Raspe, Luis Campos
Addressing the current collision course between growing healthcare demands, rising costs and limited resources is an extremely complex challenge for most healthcare systems worldwide. Given the consensus that this critical reality is unsustainable from staff, consumer, and financial perspectives, our aim was to describe the official position and approach of the Working Group on Professional Issues and Quality of Care of the European Federation of Internal Medicine (EFIM), for encouraging internists to lead a thorough reengineering of hospital operational procedures by the implementation of innovative hospital ambulatory care strategies...
April 13, 2018: European Journal of Internal Medicine
Ana Luísa Maulvault, Lúcia H M L M Santos, José Ricardo Paula, Carolina Camacho, Vasco Pissarra, Fabiola Fogaça, Vera Barbosa, Ricardo Alves, Pedro Pousão Ferreira, Damià Barceló, Sara Rodriguez-Mozaz, António Marques, Mário Diniz, Rui Rosa
Antidepressants, such as venlafaxine (VFX), which are considered emerging environmental pollutants, are increasingly more present in the marine environment, and recent evidence suggest that they might have adverse effects on fish behaviour. Furthermore, altered environmental conditions associated to climate change (e.g. warming and acidification) can also have a determinant role on fish behaviour, fitness and survival. Yet, the underlying interactions between these environmental stressors (pharmaceuticals exposure and climate change) are still far from being fully understood...
April 11, 2018: Science of the Total Environment
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