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https://www.readbyqxmd.com/read/28218062/and-next%C3%A2-adnexa-self-inflicted-alopecias
#1
Nélia Cunha, Vasco Serrão, Joana Cabete, André Lencastre
No abstract text is available yet for this article.
February 1, 2017: European Journal of Dermatology: EJD
https://www.readbyqxmd.com/read/28216574/an-in-silico-identification-of-common-putative-vaccine-candidates-against-treponema-pallidum-a-reverse-vaccinology-and-subtractive-genomics-based-approach
#2
Arun Kumar Jaiswal, Sandeep Tiwari, Syed Babar Jamal, Debmalya Barh, Vasco Azevedo, Siomar C Soares
Sexually transmitted infections (STIs) are caused by a wide variety of bacteria, viruses, and parasites that are transmitted from one person to another primarily by vaginal, anal, or oral sexual contact. Syphilis is a serious disease caused by a sexually transmitted infection. Syphilis is caused by the bacterium Treponema pallidum subspecies pallidum. Treponema pallidum (T. pallidum) is a motile, gram-negative spirochete, which can be transmitted both sexually and from mother to child, and can invade virtually any organ or structure in the human body...
February 14, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28203226/microbial-anti-inflammatory-molecule-mam-from-faecalibacterium-prausnitzii-shows-a-protective-effect-on-dnbs-and-dss-induced-colitis-model-in-mice-through-inhibition-of-nf-%C3%AE%C2%BAb-pathway
#3
Natalia M Breyner, Cristophe Michon, Cassiana S de Sousa, Priscilla B Vilas Boas, Florian Chain, Vasco A Azevedo, Philippe Langella, Jean M Chatel
Faecalibacterium prausnitzii and its supernatant showed protective effects in different chemically-induced colitis models in mice. Recently, we described 7 peptides found in the F. prausnitzii supernatant, all belonging to a protein called Microbial Anti-inflammatory Molecule (MAM). These peptides were able to inhibit NF-κB pathway in vitro and showed anti-inflammatory properties in vivo in a DiNitroBenzene Sulfate (DNBS)-induced colitis model. In this current proof we tested MAM effect on NF-κB pathway in vivo, using a transgenic model of mice producing luciferase under the control of NF-κB promoter...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28196936/influences-of-duration-of-inspiratory-effort-respiratory-mechanics-and-ventilator-type-on-asynchrony-with-pressure-support-and-proportional-assist-ventilation
#4
Renata S Vasconcelos, Raquel P Sales, Luíz H de P Melo, Liégina S Marinho, Vasco Pd Bastos, Andréa da Nc Nogueira, Juliana C Ferreira, Marcelo A Holanda
BACKGROUND: Pressure support ventilation (PSV) is often associated with patient-ventilator asynchrony. Proportional assist ventilation (PAV) offers inspiratory assistance proportional to patient effort, minimizing patient-ventilator asynchrony. The objective of this study was to evaluate the influence of respiratory mechanics and patient effort on patient-ventilator asynchrony during PSV and PAV plus (PAV+). METHODS: We used a mechanical lung simulator and studied 3 respiratory mechanics profiles (normal, obstructive, and restrictive), with variations in the duration of inspiratory effort: 0...
February 14, 2017: Respiratory Care
https://www.readbyqxmd.com/read/28194152/hsp65-producing-lactococcus-lactis-prevents-inflammatory-intestinal-disease-in-mice-by-il-10-and-tlr2-dependent-pathways
#5
Ana Cristina Gomes-Santos, Rafael Pires de Oliveira, Thaís Garcias Moreira, Archimedes Barbosa Castro-Junior, Bernardo Coelho Horta, Luísa Lemos, Leonardo Augusto de Almeida, Rafael Machado Rezende, Denise Carmona Cara, Sérgio Costa Oliveira, Vasco Ariston Carvalho Azevedo, Anderson Miyoshi, Ana Maria Caetano Faria
Heat shock proteins (Hsps) are highly expressed at all sites of inflammation. As they are ubiquitous and immunodominant antigens, these molecules represent good candidates for the therapeutic use of oral tolerance in autoimmune and chronic inflammatory diseases. Evidences from human and animal studies indicate that inflammatory bowel disease (IBD) results from uncontrolled inflammatory responses to intestinal microbiota. Hsps are immunodominant proteins expressed by several immune cells and by commensal bacteria...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28193209/secretion-of-biologically-active-pancreatitis-associated-protein-i-pap-by-genetically-modified-dairy-lactococcus-lactis-nz9000-in-the-prevention-of-intestinal-mucositis
#6
Rodrigo D Carvalho, Natalia Breyner, Zelia Menezes-Garcia, Nubia M Rodrigues, Luisa Lemos, Tatiane U Maioli, Danielle da Gloria Souza, Denise Carmona, Ana M C de Faria, Philippe Langella, Jean-Marc Chatel, Luis G Bermúdez-Humarán, Henrique C P Figueiredo, Vasco Azevedo, Marcela S de Azevedo
BACKGROUND: Mucositis is one of the most relevant gastrointestinal inflammatory conditions in humans, generated by the use of chemotherapy drugs, such as 5-fluoracil (5-FU). 5-FU-induced mucositis affects 80% of patients undergoing oncological treatment causing mucosal gut dysfunctions and great discomfort. As current therapy drugs presents limitations in alleviating mucositis symptoms, alternative strategies are being pursued. Recent studies have shown that the antimicrobial pancreatitis-associated protein (PAP) has a protective role in intestinal inflammatory processes...
February 13, 2017: Microbial Cell Factories
https://www.readbyqxmd.com/read/28191778/generation-of-human-induced-pluripotent-stem-cell-derived-bona-fide-neural-stem-cells-for-ex-vivo-gene-therapy-of-metachromatic-leukodystrophy
#7
Vasco Meneghini, Giacomo Frati, Davide Sala, Silvia De Cicco, Marco Luciani, Chiara Cavazzin, Marianna Paulis, Wieslawa Mentzen, Francesco Morena, Serena Giannelli, Francesca Sanvito, Anna Villa, Alessandro Bulfone, Vania Broccoli, Sabata Martino, Angela Gritti
Allogeneic fetal-derived human neural stem cells (hfNSCs) that are under clinical evaluation for several neurodegenerative diseases display a favorable safety profile, but require immunosuppression upon transplantation in patients. Neural progenitors derived from patient-specific induced pluripotent stem cells (iPSCs) may be relevant for autologous ex vivo gene-therapy applications to treat genetic diseases with unmet medical need. In this scenario, obtaining iPSC-derived neural stem cells (NSCs) showing a reliable "NSC signature" is mandatory...
February 2017: Stem Cells Translational Medicine
https://www.readbyqxmd.com/read/28187427/genomic-islands-an-overview-of-current-software-and-future-improvements
#8
Siomar de Castro Soares, Letícia de Castro Oliveira, Arun Kumar Jaiswal, Vasco Azevedo
Microbes are highly diverse and widely distributed organisms. They account for ~60% of Earth’s biomass and new predictions point for the existence of 1011 to 1012 species, which are constantly sharing genes through several different mechanisms. Genomic Islands (GI) are critical in this context, as they are large regions acquired through horizontal gene transfer. Also, they present common features like genomic signature deviation, transposase genes, flanking tRNAs and insertion sequences. GIs carry large numbers of genes related to specific lifestyle and are commonly classified in Pathogenicity, Resistance, Metabolic or Symbiotic Islands...
December 22, 2016: Journal of Integrative Bioinformatics
https://www.readbyqxmd.com/read/28172784/p202-diagnosis-of-inflammatory-bowel-disease-in-asymptomatic-subjects-disease-characteristics-natural-history-and-treatment-requirements
#9
I Rodríguez-Lago, O Merino, I Azagra, A Maiz, E Zapata, R Higuera, M Fernández-Calderόn, A Iriarte, P Arreba, J Carrascosa, I Montalvo, I Portillo, U Aguirre, J L Cabriada
No abstract text is available yet for this article.
February 1, 2017: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/28163825/genomic-analysis-of-four-strains-of-corynebacterium-pseudotuberculosis-bv-equi-isolated-from-horses-showing-distinct-signs-of-infection
#10
Rafael A Baraúna, Rommel T J Ramos, Adonney A O Veras, Pablo H C G de Sá, Luís C Guimarães, Diego A das Graças, Adriana R Carneiro, Judy M Edman, Sharon J Spier, Vasco Azevedo, Artur Silva
The genomes of four strains (MB11, MB14, MB30, and MB66) of the species Corynebacterium pseudotuberculosis biovar equi were sequenced on the Ion Torrent PGM platform, completely assembled, and their gene content and structure were analyzed. The strains were isolated from horses with distinct signs of infection, including ulcerative lymphangitis, external abscesses on the chest, or internal abscesses on the liver, kidneys, and lungs. The average size of the genomes was 2.3 Mbp, with 2169 (Strain MB11) to 2235 (Strain MB14) predicted coding sequences (CDSs)...
2017: Standards in Genomic Sciences
https://www.readbyqxmd.com/read/28158268/human-mobility-in-large-cities-as-a-proxy-for-crime
#11
Carlos Caminha, Vasco Furtado, Tarcisio H C Pequeno, Caio Ponte, Hygor P M Melo, Erneson A Oliveira, José S Andrade
We investigate at the subscale of the neighborhoods of a highly populated city the incidence of property crimes in terms of both the resident and the floating population. Our results show that a relevant allometric relation could only be observed between property crimes and floating population. More precisely, the evidence of a superlinear behavior indicates that a disproportional number of property crimes occurs in regions where an increased flow of people takes place in the city. For comparison, we also found that the number of crimes of peace disturbance only correlates well, and in a superlinear fashion too, with the resident population...
2017: PloS One
https://www.readbyqxmd.com/read/28157907/characterization-of-femtosecond-inscribed-fiber-bragg-gratings-in-the-visible-spectral-region
#12
Patrícia Loren Inácio, Ivenso da Silva Vasco Sualehe, Ismael Chiamenti, Valmir de Oliveira, Hypolito José Kalinowski
The femtosecond-laser pulse inscription and characterization of fiber Bragg gratings for operation at visible wavelengths was performed using several types of optical fibers, including single-mode and graded-index fibers designed for near-infrared wavelengths. The obtained bandwidths are very narrow (∼0.12-0.36  nm) for the used exposure conditions, even in graded-index fibers. Thermal and strain characterization was performed, with results about half of those found for C-band gratings. The wavelength dependence of the sensitivity is compared with a Sellmeier model...
January 20, 2017: Applied Optics
https://www.readbyqxmd.com/read/28150535/molecular-and-antimicrobial-susceptibility-characterization-of-globicatella-sulfidifaciens-isolated-from-sow-s-urinary-tract-infection
#13
Carlos E C Matajira, Luisa Z Moreno, Vasco T M Gomes, Ana Paula S Silva, Renan E Mesquita, Cristina R Amigo, Ana Paula G Christ, Maria Inês Z Sato, Andrea M Moreno
BACKGROUND: The Globicatella genus comprises Gram-positive, facultative anaerobic, α-hemolytic and catalase negative cocci morphologically and phenotypically very similar to Streptococcus and Aerococcus genus which can lead to misidentification and underestimation of this pathogen. Globicatella species have already been isolated from human and animals with heart and brain disorders. Their clinical relevance in animals, and its zoonotic potential, remains unknown due to the difficulty in their identification...
December 2017: Veterinary Quarterly
https://www.readbyqxmd.com/read/28149420/repeated-dribbling-ability-in-young-soccer-players-reproducibility-and-variation-by-the-competitive-level
#14
João P Duarte, Óscar Tavares, João Valente-Dos-Santos, Vítor Severino, Alexis Ahmed, Ricardo Rebelo-Gonçalves, João R Pereira, Vasco Vaz, Susana Póvoas, André Seabra, Sean P Cumming, Manuel J Coelho-E-Silva
The intermittent nature of match performance in youth soccer supports relevance of ability to repeatedly produce high-intensity actions with short recovery periods. This study was aimed to examine the reproducibility of a repeated dribbling ability protocol and, additionally, to estimate the contribution of concurrent tests to explain inter-individual variability in repeated dribbling output. The total sample comprised 98 players who were assessed as two independent samples: 31 players were assessed twice to examine reliability of the protocol; and 67 juveniles aged 16...
December 1, 2016: Journal of Human Kinetics
https://www.readbyqxmd.com/read/28147507/pattern-reverberation-in-networks-of-excitable-systems-with-connection-delays
#15
Leonhard Lücken, David P Rosin, Vasco M Worlitzer, Serhiy Yanchuk
We consider the recurrent pulse-coupled networks of excitable elements with delayed connections, which are inspired by the biological neural networks. If the delays are tuned appropriately, the network can either stay in the steady resting state, or alternatively, exhibit a desired spiking pattern. It is shown that such a network can be used as a pattern-recognition system. More specifically, the application of the correct pattern as an external input to the network leads to a self-sustained reverberation of the encoded pattern...
January 2017: Chaos
https://www.readbyqxmd.com/read/28134919/the-xanthophyll-cycle-affects-reversible-interactions-between-psbs-and-light-harvesting-complex-ii-to-control-non-photochemical-quenching
#16
Joanna Sacharz, Vasco Giovagnetti, Petra Ungerer, Giulia Mastroianni, Alexander V Ruban
To maintain high photosynthetic rates, plants must adapt to their light environment on a timescale of seconds to minutes. Therefore, the light-harvesting antenna system of photosystem II in thylakoid membranes, light-harvesting complex II (LHCII), has a feedback mechanism, which determines the proportion of absorbed energy dissipated as heat: non-photochemical chlorophyll fluorescence quenching (NPQ). This is crucial to prevent photo-oxidative damage to photosystem II (PSII) and is controlled by the transmembrane pH differences (ΔpH)...
January 30, 2017: Nature Plants
https://www.readbyqxmd.com/read/28133957/efficacy-and-safety-of-vaccination-in-pediatric-patients-with-systemic-inflammatory-rheumatic-diseases-a-systematic-review-of-the-literature
#17
Sandra Sousa, Ana Catarina Duarte, Inês Cordeiro, Joana Ferreira, Maria João Gonçalves, Tiago Meirinhos, Teresa Martins Rocha, Vasco C Romão, Maria José Santos
INTRODUCTION: Children and adolescents with systemic rheumatic diseases have an increased risk of infections. Although some infections are vaccine-preventable, immunization among patients with juvenile rheumatic diseases is suboptimal, partly due to some doubts that still persist regarding its efficacy and safety in this patient population. OBJECTIVES: To review the available evidence regarding the immunological response and the safety of vaccination in children and adolescents with systemic inflammatory rheumatic diseases (SIRD)...
November 9, 2016: Acta Reumatológica Portuguesa
https://www.readbyqxmd.com/read/28125655/assessing-the-genotypic-differences-between-strains-of-corynebacterium-pseudotuberculosis-biovar-equi-through-comparative-genomics
#18
Rafael A Baraúna, Rommel T J Ramos, Adonney A O Veras, Kenny C Pinheiro, Leandro J Benevides, Marcus V C Viana, Luís C Guimarães, Judy M Edman, Sharon J Spier, Vasco Azevedo, Artur Silva
Seven genomes of Corynebacterium pseudotuberculosis biovar equi were sequenced on the Ion Torrent PGM platform, generating high-quality scaffolds over 2.35 Mbp. This bacterium is the causative agent of disease known as "pigeon fever" which commonly affects horses worldwide. The pangenome of biovar equi was calculated and two phylogenomic approaches were used to identify clustering patterns within Corynebacterium genus. Furthermore, other comparative analyses were performed including the prediction of genomic islands and prophages, and SNP-based phylogeny...
2017: PloS One
https://www.readbyqxmd.com/read/28111281/aerosolizable-gold-nano-in-micro-dry-powder-formulations-for-theragnosis-and-lung-delivery
#19
A Sofia Silva, Ana M Sousa, Renato P Cabral, Marta C Silva, Clarinda Costa, Sónia P Miguel, Vasco D B Bonifácio, Teresa Casimiro, Ilídio J Correia, Ana Aguiar-Ricardo
Functionalized gold nanoparticles (AuNPs) have been widely investigated as promising multifunctional nanosystems for the theragnosis of lung cancer, the most common and prominent cause of cancer death worldwide. Nevertheless, nanoparticles are not in appropriate sizes for an accurate deep lung delivery and the lack of locally and effective delivery of therapeutic biomolecules to the deep lungs is, in fact, the major cause of low therapeutic outcome. Herein we incorporate, for the first time, AuNPs into respirable microparticles...
January 19, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28105921/simba-a-web-tool-for-managing-bacterial-genome-assembly-generated-by-ion-pgm-sequencing-technology
#20
Diego C B Mariano, Felipe L Pereira, Edgar L Aguiar, Letícia C Oliveira, Leandro Benevides, Luís C Guimarães, Edson L Folador, Thiago J Sousa, Preetam Ghosh, Debmalya Barh, Henrique C P Figueiredo, Artur Silva, Rommel T J Ramos, Vasco A C Azevedo
BACKGROUND: The evolution of Next-Generation Sequencing (NGS) has considerably reduced the cost per sequenced-base, allowing a significant rise of sequencing projects, mainly in prokaryotes. However, the range of available NGS platforms requires different strategies and software to correctly assemble genomes. Different strategies are necessary to properly complete an assembly project, in addition to the installation or modification of various software. This requires users to have significant expertise in these software and command line scripting experience on Unix platforms, besides possessing the basic expertise on methodologies and techniques for genome assembly...
December 15, 2016: BMC Bioinformatics
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