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https://www.readbyqxmd.com/read/28926336/extensive-atypical-hsv-2-ulceration-of-the-finger
#1
Nélia Cunha, Pedro Simões, Vasco Serrão
No abstract text is available yet for this article.
August 31, 2017: Acta Médica Portuguesa
https://www.readbyqxmd.com/read/28923787/first-in-man-randomized-comparison-of-buma-supreme-biodegradable-polymer-sirolimus-eluting-versus-durable-polymer-zotarolimus-eluting-coronary-stents-the-pioneer-trial
#2
Clemens von Birgelen, Taku Asano, Giovanni Amoroso, Adel Aminian, Salvatore Brugaletta, Mathias Vrolix, Rosana Hernandez-Antolín, Pim van de Harst, Andres Iñiguez, Luc Janssens, Pieter C Smits, Joanna J Wykrzykowska, Vasco Gama Ribeiro, Helder Periera, Pedro Canas da Silva, Jan J Piek, Yoshinobu Onuma, Patrick W Serruys, Manel Sabaté
AIMS: A second iteration of a sirolimus-eluting stent (SES) that has a biodegradable PLGA-polymer coating with electrografting base layer on a thin-strut (80µm) cobalt-chromium platform (BuMA Supreme; SINOMED, Tianjin, China) has been developed. This first-in-man trial assessed the efficacy and safety of the novel device. METHODS AND RESULTS: This randomized, multi-center, single-blinded, non-inferiority trial compared BuMA Supreme SES versus contemporary durable polymer zotarolimus-eluting stents (ZES) in terms of angiographic in-stent late lumen loss (LLL) at 9-months follow-up as the primary endpoint...
September 19, 2017: EuroIntervention
https://www.readbyqxmd.com/read/28918346/anaerobic-digestion-for-bioenergy-production-global-status-environmental-and-techno-economic-implications-and-government-policies
#3
REVIEW
Juliana Vasco-Correa, Sami Khanal, Ashish Manandhar, Ajay Shah
Anaerobic digestion (AD) is a mature technology that can transform organic matter into a bioenergy source - biogas (composed mainly of methane and carbon dioxide), while stabilizing waste. AD implementation around the world varies significantly, from small-scale household digesters in developing countries to large farm-scale or centralized digesters in developed countries. These differences in the implementation of AD technology are due to a complex set of conditions, including economic and environmental implications of the AD technology, and stimulus provided by a variety of polices and incentives related to agricultural systems, waste management, and renewable energy production...
September 5, 2017: Bioresource Technology
https://www.readbyqxmd.com/read/28917218/erythema-elevatum-diutinum-in-crohn-s-disease-associated-spondyloarthritis-a-rare-vasculitis-an-unusual-association
#4
Maria João Gonçalves, Vasco C Romão, Luís Soares-de-Almeida, Helena Canhão, José Carlos Romeu, Heinz Kutzner, José Alberto Pereira-da-Silva
Erythema elevatum diutinum is a rare neutrophilic dermatoses with vasculitis, which presents as persistent, symmetrical, purple or brownish papules and nodules, mainly in the extensor surface of the limbs. We describe a case of erythema elevatum diutinum and polyarthritis as initial manifestations of Crohn's disease associated spondyloarthritis. A 51-year-old man, from São Tomé e Príncipe, with previous history of treated tuberculosis and chronic hepatitis B infection, was admitted due to 4 months history of polyarthritis, hyperpigmented papules on the extensor surfaces, occasional episodes of bloody mucous diarrhea and significant weight loss...
September 14, 2017: Acta Reumatológica Portuguesa
https://www.readbyqxmd.com/read/28904771/sorting-things-out-assessing-effects-of-unequal-specimen-biomass-on-dna-metabarcoding
#5
Vasco Elbrecht, Bianca Peinert, Florian Leese
Environmental bulk samples often contain many different taxa that vary several orders of magnitude in biomass. This can be problematic in DNA metabarcoding and metagenomic high-throughput sequencing approaches, as large specimens contribute disproportionately high amounts of DNA template. Thus, a few specimens of high biomass will dominate the dataset, potentially leading to smaller specimens remaining undetected. Sorting of samples by specimen size (as a proxy for biomass) and balancing the amounts of tissue used per size fraction should improve detection rates, but this approach has not been systematically tested...
September 2017: Ecology and Evolution
https://www.readbyqxmd.com/read/28890071/serum-lipid-alterations-in-gba-associated-parkinson-s-disease
#6
Leonor Correia Guedes, Robin Barry Chan, Marcos António Gomes, Vasco A Conceição, Raquel Bouça Machado, Tiago Soares, Yimeng Xu, Paulo Gaspar, Joao André Carriço, Roy N Alcalay, Joaquim J Ferreira, Tiago Fleming Outeiro, Gabriel Miltenberger-Miltenyi
INTRODUCTION: Mutations in the GBA gene, encoding for the lysosomal enzyme glucocerebrosidase, are associated with Gaucher disease. Alterations in plasma sphingolipids have been reported in Gaucher, and similarly in brain extracts in Lewy body disease. As GBA mutations are prevalent risk factors for Parkinson's disease and overlap of molecular pathways are presumable, here we assessed the lipid profiles in Parkinson's patients with and without GBA mutations. METHODS: We sequenced all GBA exons in 415 Parkinson's patients, previously genotyped for LRRK2...
September 1, 2017: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/28888870/efficient-differentiation-of-corynebacterium-striatum-corynebacterium-amycolatum-and-corynebacterium-xerosis-clinical-isolates-by-multiplex-pcr-using-novel-species-specific-primers
#7
Carolina S Santos, Juliana N Ramos, Veronica V Vieira, Carina S Pinheiro, Roberto Meyer, Neuza M Alcantara-Neves, Rommel T Ramos, Artur Silva, Raphael Hirata, Liza Felicori, Carlos Ruiz de Alegría Puig, Jesús Navas, Vasco Azevedo, Ana L Mattos-Guaraldi, Luis G C Pacheco
A multiplex-PCR (mPCR) assay was designed with species-specific primers which generate amplicons of 226bp, 434bp and 106bp for differentiating the species C. striatum, C. amycolatum, and C. xerosis, respectively. mPCR results were 100% in agreement with identifications achieved by 16S rRNA and rpoB gene sequencing and by VITEK-MS.
September 6, 2017: Journal of Microbiological Methods
https://www.readbyqxmd.com/read/28886017/b-cell-phenotype-and-igd-cd27-memory-b-cells-are-affected-by-tnf-inhibitors-and-tocilizumab-treatment-in-rheumatoid-arthritis
#8
Rita A Moura, Cláudia Quaresma, Ana R Vieira, Maria J Gonçalves, Joaquim Polido-Pereira, Vasco C Romão, Nádia Martins, Helena Canhão, João E Fonseca
BACKGROUND: The use of TNF-inhibitors and/or the IL-6 receptor antagonist, tocilizumab, in rheumatoid arthritis (RA) have pleiotropic effects that also involve circulating B-cells. The main goal of this study was to assess the effect of TNF-inhibitors and tocilizumab on B-cell phenotype and gene expression in RA. METHODS: Blood samples were collected from untreated early RA (ERA) patients, established RA patients under methotrexate treatment, established RA patients before and after treatment with TNF-inhibitors and tocilizumab, and healthy donors...
2017: PloS One
https://www.readbyqxmd.com/read/28880978/quantitative-assessment-of-microstructural-changes-of-the-retina-in-infants-with-congenital-zika-syndrome
#9
Tomas S Aleman, Camila V Ventura, Milena M Cavalcanti, Leona W Serrano, Anastasia Traband, Akosua A Nti, Adriana L Gois, Vasco Bravo-Filho, Thayze T Martins, Charles W Nichols, Mauricio Maia, Rubens Belfort
Importance: A better pathophysiologic understanding of the neurodevelopmental abnormalities observed in neonates exposed in utero to Zika virus (ZIKV) is needed to develop treatments. The retina as an extension of the diencephalon accessible to in vivo microcopy with spectral-domain optical coherence tomography (SD-OCT) can provide an insight into the pathophysiology of congenital Zika syndrome (CZS). Objective: To quantify the microstructural changes of the retina in CZS and compare these changes with those of cobalamin C (cblC) deficiency, a disease with potential retinal maldevelopment...
September 7, 2017: JAMA Ophthalmology
https://www.readbyqxmd.com/read/28867472/symmetrical-peripheral-gangrene
#10
Ana Carina Ferreira, Vasco Fernandes
No abstract text is available yet for this article.
August 31, 2017: European Journal of Vascular and Endovascular Surgery
https://www.readbyqxmd.com/read/28857350/analysing-phase-progression-in-susan-s-case
#11
Joana F Ferreira, António B Vasco, Michael Basseches, Andreia Santos, João M Ferreira
This study adds a phase-by-phase perspective to the case of Susan, with the aim of better understanding the processes of change in this therapeutic case. A team of 3 raters integrated the sequential phases of the Paradigmatic Complementarity Metamodel with a moment-by-moment tracking method-the Developmental Analysis of Psychotherapy Process method-to analyse this therapeutic process and clarify what happened throughout that may explain phase gains and how the therapist facilitated them. The results suggest that Susan evolved in accordance with the sequence of phases proposed by the Paradigmatic Complementarity Metamodel...
August 31, 2017: Clinical Psychology & Psychotherapy
https://www.readbyqxmd.com/read/28856761/tracking-and-understanding-phase-progression-in-lisa-s-case
#12
Joana F Ferreira, António B Vasco, Michael Basseches, Nuno Conceição, Catarina Vaz-Velho, Rhonda Goldman
This study adds a phase-by-phase perspective to the well-known, and thoroughly analysed on a moment-by-moment basis, case of Lisa. The aim is to see whether this phase-by-phase analysis adds anything valuable to the understanding of the processes of change in this case and the therapeutic processes in general. In this good-outcome case study, a team of raters integrated the temporal sequencing phase component of the Paradigmatic Complementarity Metamodel (PCM) with a moment-by-moment tracking method-the Developmental Analysis of Psychotherapy Process Method (DAPP)-to analyse what occurred along the process that could explain the phase transitions and consolidations observed and how the therapist facilitated them...
August 30, 2017: Clinical Psychology & Psychotherapy
https://www.readbyqxmd.com/read/28856147/anti-cardiac-troponin-antibodies-in-clinical-human-disease-a-systematic-review
#13
REVIEW
Eduardo M Vilela, Rita Bettencourt-Silva, J Torres da Costa, Ana Raquel Barbosa, Marisa P Silva, Madalena Teixeira, João Primo, Vasco Gama Ribeiro, José Pedro L Nunes
Anti-cardiac troponin antibodies have been studied in different types of clinical diseases and in healthy populations. A systematic review of published data on anti-troponin antibodies was carried out (search performed on PubMed, ISI Web of Knowledge and Scopus databases). From title and abstract analysis, thirty-three articles were included that met the pre-specified criteria; after full-text analysis, nine articles were excluded. Most studies assessed anti-troponin I antibodies. The prevalence of anti-cardiac troponin antibodies in healthy individuals ranged from 0...
August 2017: Annals of Translational Medicine
https://www.readbyqxmd.com/read/28852474/the-prevalence-of-pulmonary-complications-after-thoracic-and-abdominal-surgery-and-associated-risk-factors-in-patients-admitted-at-a-government-hospital-in-harare-zimbabwe-a-retrospective-study
#14
Cathrine Tadyanemhandu, Rufaro Mukombachoto, Clement Nhunzvi, Farayi Kaseke, Vasco Chikwasha, Samson Chengetanai, Shamila Manie
BACKGROUND: The burden of HIV/AIDS in Sub-Saharan Africa has presented unusual and challenging acute surgical problems across all specialties. Thoraco-abdominal surgery cuts through muscle and thereby disrupts the normal anatomy and activity of the respiratory muscles leading to reduced lung volumes and putting the patients at greater risk of developing post-operative pulmonary complications (PPCs). PPCs remain an important cause of post-operative morbidity, mortality, and impacts on the long-term outcomes of patients post hospital discharge...
2017: Perioperative Medicine
https://www.readbyqxmd.com/read/28844528/association-between-implantation-depth-assessed-by-computed-tomography-and-new-onset-conduction-disturbances-after-transcatheter-aortic-valve-implantation
#15
João Gonçalves Almeida, Sara Moura Ferreira, Paulo Fonseca, Tiago Dias, Cláudio Guerreiro, Ana Raquel Barbosa, Pedro Teixeira, Mónica Carvalho, Wilson Ferreira, Nuno Dias Ferreira, Marco Oliveira, Helena Gonçalves, Pedro Braga, José Ribeiro, João Primo, Vasco Gama Ribeiro
BACKGROUND: Transcatheter aortic valve replacement (TAVR) is often associated with intraventricular conduction disturbances. We aimed to determine the association between implantation depth assessed by multidetector computed tomography (MDCT) and new-onset conduction abnormalities after TAVR. METHODS: Retrospective single-center study including patients consecutively submitted to TAVR, between August/2007 and October/2016, who underwent routine MDCT 3 months after the procedure...
August 18, 2017: Journal of Cardiovascular Computed Tomography
https://www.readbyqxmd.com/read/28830056/multiple-stressor-effects-on-stream-macroinvertebrate-communities-a-mesocosm-experiment-manipulating-salinity-fine-sediment-and-flow-velocity
#16
Arne J Beermann, Vasco Elbrecht, Svenja Karnatz, Li Ma, Christoph D Matthaei, Jeremy J Piggott, Florian Leese
Stream ecosystems are impacted by multiple stressors worldwide. Recent studies have shown that the effects of multiple stressors are often complex and difficult to predict based on the effects of single stressors. More research is needed to understand stressor impacts on stream communities and to design appropriate counteractions. We carried out an outdoor mesocosm experiment to assess single and interactive multiple-stressor effects on stream macroinvertebrates in a setup with controlled application of three globally important stressors, namely, reduced stream flow velocity, deposition of fine sediment and increased chloride concentration in a full-factorial design...
August 19, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28821820/searching-for-signatures-across-microbial-communities-metagenomic-analysis-of-soil-samples-from-mangrove-and-other-ecosystems
#17
Madangchanok Imchen, Ranjith Kumavath, Debmalya Barh, Vasco Avezedo, Preetam Ghosh, Marcus Viana, Alice R Wattam
In this study, we categorize the microbial community in mangrove sediment samples from four different locations within a vast mangrove system in Kerala, India. We compared this data to other samples taken from the other known mangrove data, a tropical rainforest, and ocean sediment. An examination of the microbial communities from a large mangrove forest that stretches across southwestern India showed strong similarities across the higher taxonomic levels. When ocean sediment and a single isolate from a tropical rain forest were included in the analysis, a strong pattern emerged with Bacteria from the phylum Proteobacteria being the prominent taxon among the forest samples...
August 18, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28819588/corrigendum-heterogeneous-family-of-cyclomodulins-smart-weapons-that-allow-bacteria-to-hijack-the-eukaryotic-cell-cycle-and-promote-infections
#18
Rachid A El-Aouar Filho, Aurélie Nicolas, Thiago L De Paula Castro, Martine Deplanche, Vasco A De Carvalho Azevedo, Pierre L Goossens, Frédéric Taieb, Gerard Lina, Yves Le Loir, Nadia Berkova
[This corrects the article on p. 208 in vol. 7, PMID: 28589102.].
2017: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/28811509/determining-causal-mirnas-and-their-signaling-cascade-in-diseases-using-an-influence-diffusion-model
#19
Joseph J Nalluri, Pratip Rana, Debmalya Barh, Vasco Azevedo, Thang N Dinh, Vladimir Vladimirov, Preetam Ghosh
In recent studies, miRNAs have been found to be extremely influential in many of the essential biological processes. They exhibit a self-regulatory mechanism through which they act as positive/negative regulators of expression of genes and other miRNAs. This has direct implications in the regulation of various pathophysiological conditions, signaling pathways and different types of cancers. Studying miRNA-disease associations has been an extensive area of research; however deciphering miRNA-miRNA network regulatory patterns in several diseases remains a challenge...
August 15, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28802258/human-blood-tfr-cells-are-indicators-of-ongoing-humoral-activity-not-fully-licensed-with-suppressive-function
#20
Valter R Fonseca, Ana Agua-Doce, Ana Raquel Maceiras, Wim Pierson, Filipa Ribeiro, Vasco C Romão, Ana Rita Pires, Susana Lopes da Silva, João Eurico Fonseca, Ana E Sousa, Michelle A Linterman, Luis Graca
Germinal center (GC) responses are controlled by T follicular helper (Tfh) and T follicular regulatory (Tfr) cells and are crucial for the generation of high-affinity antibodies. Although the biology of human circulating and tissue Tfh cells has been established, the relationship between blood and tissue Tfr cells defined as CXCR5(+)Foxp3(+) T cells remains elusive. We found that blood Tfr cells are increased in Sjögren syndrome, an autoimmune disease with ongoing GC reactions, especially in patients with high autoantibody titers, as well as in healthy individuals upon influenza vaccination...
August 11, 2017: Science Immunology
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