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https://www.readbyqxmd.com/read/29034862/ultrastructural-and-microbial-analyses-of-cellulose-degradation-in-leaf-cutter-ant-colonies
#1
Rolando Daniel Moreira-Soto, Ethel Sanchez, Cameron R Currie, Adrian A Pinto-Tomás
Leaf-cutter ants (Atta and Acromyrmex) use fresh leaves to cultivate a mutualistic fungus (Leucoagaricus gongylophorus) for food in underground gardens. A new ant queen propagates the cultivar by taking a small fragment of fungus from her parent colony on her nuptial flight and uses it to begin her own colony. Recent research has shown that the ants' fungus gardens are colonized by symbiotic bacteria that perform important functions related to nitrogen fixation and have been implicated in contributing to plant biomass degradation...
October 16, 2017: Microbiology
https://www.readbyqxmd.com/read/29033957/reacquisition-of-new-meristematic-sites-determines-the-development-of-a-new-organ-the-cecidomyiidae-gall-on-copaifera-langsdorffii-desf-fabaceae
#2
Renê G S Carneiro, Rosy M S Isaias, Ana S F P Moreira, Denis C Oliveira
The development of gall shapes has been attributed to the feeding behavior of the galling insects and how the host tissues react to galling stimuli, which ultimately culminate in a variable set of structural responses. A superhost of galling herbivores, Copaifera langsdorffii, hosts a bizarre "horn-shaped" leaflet gall morphotype induced by an unidentified species of Diptera: Cecidomyiidae. By studying the development of this gall morphotype under the anatomical and physiological perspectives, we demonstrate the symptoms of the Cecidomyiidae manipulation over plant tissues, toward the cell redifferentiation and tissue neoformation...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/29033090/the-antimicrobial-peptide-ll-37-as-a-possible-adjunct-for-the-proliferation-and-differentiation-of-dental-pulp-stem-cells
#3
Noala Vicensoto Moreira Milhan, Patricia Pimentel de Barros, Elis Andrade de Lima Zutin, Felipe Eduardo de Oliveira, Carlos Henrique Ribeiro Camargo, Samira Esteves Afonso Camargo
INTRODUCTION: This study evaluated the biocompatibility of 5 and 10 μg/mL LL-37 in vitro and its effect on the differentiation of human dental pulp stem cells (DPSCs) into odontoblast-like cells. METHODS: Cell viability, genotoxicity, nitric oxide production, cell cycle, dentine sialophosphoprotein (DSPP) production, and DSPP gene expression. RESULTS: Concentrations of 5 and 10 μg/mL of LL-37 were not cytotoxic and generally increased cell viability, especially on the third day (P < ...
October 12, 2017: Journal of Endodontics
https://www.readbyqxmd.com/read/29032809/evaluation-of-polycyclic-aromatic-hydrocarbons-bioavailability-on-santos-bay-brazil-through-levels-of-biliary-metabolites
#4
Ana Cecília Rizzatti de Albergaria-Barbosa, Denis Albuquerque Moreira da Silva, Arthur José da Silva Rocha, Satie Taniguchi, Vinicius Faria Patire, June Ferraz Dias, Wellington Silva Fernandez, Marcia Caruso Bícego
This study evaluated the PAH bioavailability from Santos Bay (Brazil) in 4 species of fish, using PAH biliary metabolites. The collection was done monthly, between July and December, in three different regions of Santos Bay. The metabolites were analyzed through a high performance liquid chromatograph with fluorescence detectors. Total metabolites concentrations ranged from 65.5 to 589μgg(-1) of bile, evidencing PAH bioavailability on Santos Bay. Levels of phenanthrene and benzo[a]pyrene metabolites were in the classification range of areas moderate contaminated...
October 10, 2017: Marine Pollution Bulletin
https://www.readbyqxmd.com/read/29032512/il-33-signalling-in-liver-immune-cells-enhances-drug-induced-liver-injury-and-inflammation
#5
Maísa Mota Antunes, Alan Moreira Araújo, Ariane Barros Diniz, Rafaela Vaz Sousa Pereira, Débora Moreira Alvarenga, Bruna Araújo David, Renata Monti Rocha, Maria Alice Freitas Lopes, Sarah Cozzer Marchesi, Brenda Naemi Nakagaki, Érika Carvalho, Pedro Elias Marques, Bernhard Ryffel, Valérie Quesniaux, Rodrigo Guabiraba Brito, José Carlos Alves Filho, Denise Carmona Cara, Rafael Machado Rezende, Gustavo Batista Menezes
OBJECTIVE AND DESIGN: The aim of this study was to investigate the contribution of IL-33/ST2 axis in the onset and progression of acute liver injury using a mice model of drug-induced liver injury (DILI). MATERIAL AND TREATMENTS: DILI was induced by overdose administration of acetaminophen (APAP) by oral gavage in wild-type BALB/c, ST2-deficient mice and in different bone marrow chimeras. Neutrophils were depleted by anti-Ly6G and macrophages with clodronate liposomes (CLL)...
October 14, 2017: Inflammation Research: Official Journal of the European Histamine Research Society ... [et Al.]
https://www.readbyqxmd.com/read/29032505/impaired-chemosensory-control-of-breathing-after-depletion-of-bulbospinal-catecholaminergic-neurons-in-rats
#6
Milene R Malheiros-Lima, Leonardo T Totola, Ana C Takakura, Thiago S Moreira
Bulbospinal catecholaminergic neurons located in the rostral aspect of the ventrolateral medulla (C1 neurons) or within the ventrolateral pons (A5 neurons) are involved in the regulation of blood pressure and sympathetic outflow. A stimulus that commonly activates the C1 or A5 neurons is hypoxia, which is also involved in breathing activation. Although pharmacological and optogenetic evidence suggests that catecholaminergic neurons also regulate breathing, a specific contribution of the bulbospinal neurons to respiratory control has not been demonstrated...
October 14, 2017: Pflügers Archiv: European Journal of Physiology
https://www.readbyqxmd.com/read/29031078/structural-design-synthesis-and-pharmacological-evaluation-of-thiazoles-against-trypanosoma-cruzi
#7
Gevanio Bezerra de Oliveira Filho, Marcos Veríssimo de Oliveira Cardoso, José Wanderlan Pontes Espíndola, Dayane Albuquerque Oliveira E Silva, Rafaela Salgado Ferreira, Pollyanne Lacerda Coelho, Pâmela Silva Dos Anjos, Emanuelle de Souza Santos, Cássio Santana Meira, Diogo Rodrigo Magalhaes Moreira, Milena Botelho Pereira Soares, Ana Cristina Lima Leite
Chagas disease is one of the most significant health problems in the American continent. benznidazole (BDZ) and nifurtimox (NFX) are the only drugs approved for treatment and exhibit strong side effects and ineffectiveness in the chronic stage, besides different susceptibility among T. cruzi DTUs (Discrete Typing Units). Therefore, new drugs to treat this disease are necessary. Thiazole compounds have been described as potent trypanocidal agents. Here we report the structural planning, synthesis and anti-T...
September 22, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29031042/humoral-and-cellular-immune-response-of-mice-challenged-with-yersinia-pestis-antigenic-preparations
#8
Elida A Leal, Josimar D Moreira, Fernanda F Nunes, Larissa R Souza, Janaina M Martins, Vicente P C Toledo, Alzira M P Almeida, Tania M P Guimarães
OBJECTIVES: The plague, which is an infectious disease caused by Yersinia pestis, still threatens many populations in several countries. The worldwide increase in human plague cases and the potential use of the bacteria as a biological weapon reinforce the need to study the immunity that is induced by potential vaccine candidates. To determine the immunogenicity of antigenic preparations based on the F1 protein and the total extract from Y. pestis, we assessed the role of these antigens in inducing an immune response...
October 11, 2017: Brazilian Journal of Infectious Diseases
https://www.readbyqxmd.com/read/29030894/pooled-efficacy-and-safety-of-eslicarbazepine-acetate-as-add-on-treatment-in-patients-with-focal-onset-seizures-data-from-four-double-blind-placebo-controlled-pivotal-phase-iii-clinical-studies
#9
Christian Elger, Mathias Koepp, Eugen Trinka, Vicente Villanueva, João Chaves, Elinor Ben-Menachen, Pedro A Kowacs, António Gil-Nagel, Joana Moreira, Helena Gama, José-Francisco Rocha, Patrício Soares-da-Silva
PURPOSE: Pooled evaluation of the key efficacy and safety profile of eslicarbazepine acetate (ESL) added-on to stable antiepileptic therapy in adults with focal-onset seizures. METHODS: Data from 1703 patients enrolled in four phase III double-blind, randomized, placebo-controlled studies were pooled and analyzed. Following a 2 week titration period, ESL was administered at 400 mg, 800 mg, and 1200 mg once-daily doses for 12 weeks (maintenance period). Pooled efficacy variable was standardized (/4 weeks) seizure frequency (SSF) analyzed over the maintenance period as reduction in absolute and relative SSF and proportion of responders (≥50% reduction in SSF)...
October 13, 2017: CNS Neuroscience & Therapeutics
https://www.readbyqxmd.com/read/29030131/effects-of-diabetes-mellitus-and-systemic-arterial-hypertension-on-elderly-patients-hearing
#10
Laurie Penha Rolim, Alessandra Giannella Samelli, Renata Rodrigues Moreira, Carla Gentile Matas, Itamar de Souza Santos, Isabela Martins Bensenor, Paulo Andrade Lotufo
INTRODUCTION: Chronic diseases can act as an accelerating factor in the auditory system degeneration. Studies on the association between presbycusis and diabetes mellitus and systemic arterial hypertension have shown controversial conclusions. OBJECTIVE: To compare the initial audiometry (A1) with a subsequent audiometry (A2) performed after a 3 to 4-year interval in a population of elderly patients with diabetes mellitus and/or systemic arterial hypertension, to verify whether hearing loss in these groups is more accelerated when compared to controls without these clinical conditions...
September 21, 2017: Brazilian Journal of Otorhinolaryngology
https://www.readbyqxmd.com/read/29028482/adiposity-phenotypes-are-associated-with-type-2-diabetes-lap-index-body-adiposity-index-and-neck-circumference
#11
Aline Marcadenti, Flavio D Fuchs, Leila B Moreira, Miguel Gus, Sandra C Fuchs
BACKGROUND AND AIMS: Adiposity phenotypes can be detected by anthropometric indexes associated with type-2 diabetes mellitus (T2DM). Besides body mass index (BMI) and waist circumference (WC), new indices seem to be able to identify T2DM. This study aimed to evaluate independent associations of T2DM with lipid accumulation product (LAP index), neck circumference (NC) and body adiposity index (BAI) in patients with hypertension. METHODS: A cross-sectional study was carried out among 430 patients with hypertension...
September 22, 2017: Atherosclerosis
https://www.readbyqxmd.com/read/29025532/conflict-of-interest-disclosure-in-a-top-tier-portuguese-medical-journal
#12
Nuno Moreira Fonseca
INTRODUCTION: Scientific medical publications are considered to be a source of unbiased and independent information. Authors are required to disclose relationships with the pharmaceutical industry for transparency purposes. The aim of this work was to assess conflict of interest disclosure in a Portuguese top-tier medical journal by comparing authors' self-reported conflicts of interest with payments listed in the official database of Portuguese Ministry of Health. MATERIAL AND METHODS: All articles published in the Portuguese Journal of Cardiology from December 2015 to May 2016 were reviewed...
September 29, 2017: Acta Médica Portuguesa
https://www.readbyqxmd.com/read/29025527/-being-a-mother-after-35-years-will-it-be-different
#13
Bárbara Marques, Francisca Palha, Edgar Moreira, Sandra Valente, Margarida Abrantes, Joana Saldanha
INTRODUCTION: Advanced maternal age is defined as maternity after 35 years old and is associated with more complications during pregnancy and neonatal period as well as decreased fertility. This study aims to examine the relationship between advanced maternal age and their maternal and fetal consequences, as well as maternal perception of the risk of pregnancy after 35 years old. MATERIAL AND METHODS: Observational, retrospective and comparative study, between two groups: advanced maternal age group (aged ≥ 35 years) and non-advanced maternal age group (age < 35 years), conducted between March and June 2015...
September 29, 2017: Acta Médica Portuguesa
https://www.readbyqxmd.com/read/29024873/photodynamic-therapy-for-schistosoma-mansoni-promising-outcomes
#14
Nathália Bandeira de Melo, Letícia Fernanda Moreira Dos Santos, Mayara Santos de Castro, Raquel Lopes Martins Souza, Marcos José Marques, Aline Pereira Castro, Andreísa Teixeira de Castro, Marina Lara de Carli, João Adolfo Costa Hanemann, Matheus Siqueira Silva, Gabriel de Oliveira Isac Moraes, Luiz Alberto Beijo, Maísa Ribeiro Pereira Lima Brigagão, Felipe Fornias Sperandio
The purpose of this study was to assess, for the very first time, the effects of photodynamic therapy (PDT) on Schistosoma mansoni in vitro by measuring reactive oxygen species (ROS) generation throughout the treatment, as well as the behavior of the parasites (mating, motility and contraction/shortening), and damage to their tegument and excretory systems. The parasites were divided into 4 groups: control, photosensitizer, laser and PDT. Light irradiation was delivered with an InGaAlP low-level laser device operating at 660nm, with 40mW and 100J/cm(2)...
September 22, 2017: Journal of Photochemistry and Photobiology. B, Biology
https://www.readbyqxmd.com/read/29024106/nutritional-evaluation-of-the-legume-macrotyloma-axillare-using-in-vitro-and-in-vivo-bioassays-in-sheep
#15
P M T Lima, G D Moreira, G Z Sakita, A S Natel, W T Mattos, F M A Gimenes, L Gerdes, C McManus, A L Abdalla, H Louvandini
This study consisted of two experiments with the following objectives: to evaluate the effects of tannins from the tropical legume macrotiloma (Macrotyloma axillare) on total gas and methane (CH4 ) production, as well as on ruminal fermentation parameters by performing an in vitro bioassay, with samples incubated with and without polyethylene glycol (PEG) in a semi-automatic system; and secondly in a 17 day in vivo experiment, to determine apparent total tract digestibility (ATTD) of dietary nutrients and ruminal fermentation parameters of 12 intact 8- to 9-month-old Santa Inês (averaging 24...
October 10, 2017: Journal of Animal Physiology and Animal Nutrition
https://www.readbyqxmd.com/read/29022916/molecular-motion-regulates-the-activity-of-the-mitochondrial-serine-protease-htra2
#16
Matthew Merski, Cátia Moreira, Rui Mv Abreu, Maria João Ramos, Pedro A Fernandes, L Miguel Martins, Pedro José Barbosa Pereira, Sandra Macedo-Ribeiro
HtrA2 (high-temperature requirement 2) is a human mitochondrial protease that has a role in apoptosis and Parkinson's disease. The structure of HtrA2 with an intact catalytic triad was determined, revealing a conformational change in the active site loops, involving mainly the regulatory LD loop, which resulted in burial of the catalytic serine relative to the previously reported structure of the proteolytically inactive mutant. Mutations in the loops surrounding the active site that significantly restricted their mobility, reduced proteolytic activity both in vitro and in cells, suggesting that regulation of HtrA2 activity cannot be explained by a simple transition to an activated conformational state with enhanced active site accessibility...
October 12, 2017: Cell Death & Disease
https://www.readbyqxmd.com/read/29022270/exercise-training-in-pulmonary-hypertension-and-right-heart-failure-insights-from-pre-clinical-studies
#17
Daniel Moreira-Gonçalves, Rita Ferreira-Nogueira, Mário Santos, Ana Filipa Silva, Rita Ferreira, Adelino Leite-Moreira, José Alberto Duarte, Tiago Henriques-Coelho
Exercise training (ExT) is widely used for the prevention and treatment of several chronic cardiovascular diseases. However, only recently it started to be recognized as safe and beneficial in pulmonary arterial hypertension. Despite the consistency of its favorable effects on exercise tolerance and quality of life, the mechanisms underlying these meaningful clinical improvements remain unclear. Current studies emphasize the exercise-induced changes on skeletal muscle but the impact of ExT at the level of the pulmonary circulation and right ventricle should not be overlooked...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29022241/a-panel-of-protein-candidates-for-comprehensive-study-of-caprine-arthritis-encephalitis-cae-infection
#18
Rosivaldo Quirino Bezerra Júnior, Ângela Maria Xavier Eloy, João Ricardo Furtado, Raymundo Rizaldo Pinheiro, Alice Andrioli, Frederico Bruno Moreno, Marina Duarte Pinto Lobo, Ana Cristina O Monteiro-Moreira, Renato de Azevedo Moreira, Tatiana Maria Farias Pinto, Maria Fátima da Silva Teixeira
The caprine arthrite encephalite (CAE) is a disease that affects especially dairy goat. The virus shows compartmentalization features, that allows it to hide at certain times during the course of the disease, making it difficult to control. The present study was conducted to identify the major seminal plasma protein profile of goats infected by CAE and its associations with seroconversion using Western blotting. Two groups containing five males each, were used in this experiment. The first group was composed by seropositive animals and the control by seronegative confirmed by Western blotting and PCR...
October 12, 2017: Tropical Animal Health and Production
https://www.readbyqxmd.com/read/29021084/association-between-epstein-barr-virus-ebv-and-cervical-carcinoma-a-meta-analysis
#19
REVIEW
Marcos Antonio Pereira de Lima, Pedro Januário Nascimento Neto, Lívia Peixoto Moreira Lima, Jucier Gonçalves Júnior, Antonio Gilvan Teixeira Junior, Ilara Parente Pinheiro Teodoro, Heberty Tarso Facundo, Cláudio Gleidiston Lima da Silva, Marcos Venício Alves Lima
Human papillomavirus (HPV) has been implicated as a major factor in cervical carcinogenesis. However, many pieces of evidence gathered over the last two decades suggest Epstein-Barr virus (EBV) plays a secondary role in this process. The purpose of the present meta-analysis was to determine whether the presence of EBV infection increases the risk of cervical carcinoma. Based on 25 articles, the analysis yielded a 33.44% overall pooled prevalence of EBV. The pooled prevalence was higher in patients with carcinoma (43...
October 9, 2017: Gynecologic Oncology
https://www.readbyqxmd.com/read/29020125/construction-and-validation-of-educational-materials-for-the-prevention-of-metabolic-syndrome-in-adolescents
#20
Ionara Holanda de Moura, Antônia Fabiana Rodrigues da Silva, Aparecida do Espírito Santo de Holanda Rocha, Luisa Helena de Oliveira Lima, Thereza Maria Magalhães Moreira, Ana Roberta Vilarouca da Silva
OBJECTIVE: To develop and validate an educational technology focused on prevention of metabolic syndrome among adolescents. METHODS: This was methodological research. Using an integrative review, the available publications on the subject were analyzed. Then, this knowledge was used to describe the theoretical content and, with the help of a graphic designer, the art and layout of the pages were developed. In the third phase, the booklet was evaluated and validated by 21 specialists and 39 adolescents...
October 5, 2017: Revista Latino-americana de Enfermagem
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