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https://www.readbyqxmd.com/read/28726387/aryl-substituted-ruthenium-ii-complexes-a-strategy-for-enhanced-photocleavage-and-efficient-dna-binding
#1
Felipe Diógenes Abreu, Tercio de F Paulo, Marcelo H Gehlen, Rômulo A Ando, Luiz G F Lopes, Ana Cláudia S Gondim, Mayron A Vasconcelos, Edson H Teixeira, Eduardo Henrique Silva Sousa, Idalina Maria Moreira de Carvalho
Ruthenium polypyridine complexes have shown promise as agents for photodynamic therapy (PDT) and tools for molecular biology (chromophore-assisted light inactivation). To accomplish these tasks, it is important to have at least target selectivity and great reactive oxygen species (ROS) photogeneration: two properties that are not easily found in the same molecule. To prepare such new agents, we synthesized two new ruthenium complexes that combine an efficient DNA binding moiety (dppz ligand) together with naphthyl-modified (1) and anthracenyl-modified (2) bipyridine as a strong ROS generator bound to a ruthenium complex...
July 20, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/28725434/regression-of-multifocoal-in-transit-melanoma-metastases-after-palliative-resection-of-dominant-masses-and-2%C3%A2-years-after-treatment-with-ipilimumab
#2
Raphael B Moreira, Lana Hamieh, Evisa Gjini, Ana Lako, Katherine M Krajewski, Charles H Yoon, Patrick A Ott
BACKGROUND: Spontaneous regression of metastatic melanoma and delayed responses more than one year after treatment with ipilimumab are rarely seen. CASE PRESENTATION: Here, we present the case of a patient with in transit metastases from cutaneous melanoma on his right lower extremity who achieved complete regression of all metastatic lesions 13 months after the first of two consecutive palliative resections of dominant masses and more than two years after treatment with ipilimumab...
2017: Journal for Immunotherapy of Cancer
https://www.readbyqxmd.com/read/28725272/brazilian-guidelines-on-prevention-of-cardiovascular-disease-in-patients-with-diabetes-a-position-statement-from-the-brazilian-diabetes-society-sbd-the-brazilian-cardiology-society-sbc-and-the-brazilian-endocrinology-and-metabolism-society-sbem
#3
REVIEW
Marcello Casaccia Bertoluci, Rodrigo Oliveira Moreira, André Faludi, Maria Cristina Izar, Beatriz D Schaan, Cynthia Melissa Valerio, Marcelo Chiara Bertolami, Ana Paula Chacra, Marcus Vinicius Bolivar Malachias, Sérgio Vencio, José Francisco Kerr Saraiva, Roberto Betti, Luiz Turatti, Francisco Antonio Helfenstein Fonseca, Henrique Tria Bianco, Marta Sulzbach, Adriana Bertolami, João Eduardo Nunes Salles, Alexandre Hohl, Fábio Trujilho, Eduardo Gomes Lima, Marcio Hiroshi Miname, Maria Teresa Zanella, Rodrigo Lamounier, João Roberto Sá, Celso Amodeo, Antonio Carlos Pires, Raul D Santos
BACKGROUND: Since the first position statement on diabetes and cardiovascular prevention published in 2014 by the Brazilian Diabetes Society, the current view on primary and secondary prevention in diabetes has evolved as a result of new approaches on cardiovascular risk stratification, new cholesterol lowering drugs, and new anti-hyperglycemic drugs. Importantly, a pattern of risk heterogeneity has emerged, showing that not all diabetic patients are at high or very high risk. In fact, most younger patients who have no overt cardiovascular risk factors may be more adequately classified as being at intermediate or even low cardiovascular risk...
2017: Diabetology & Metabolic Syndrome
https://www.readbyqxmd.com/read/28724950/nanocapsules-containing-neem-azadirachta-indica-oil-development-characterization-and-toxicity-evaluation
#4
Tatiane Pasquoto-Stigliani, Estefânia V R Campos, Jhones L Oliveira, Camila M G Silva, Natalia Bilesky-José, Mariana Guilger, Johann Troost, Halley C Oliveira, Renata Stolf-Moreira, Leonardo F Fraceto, Renata de Lima
In this study, we prepared, characterized, and performed toxicity analyses of poly(ε-caprolactone) nanocapsules loaded with neem oil. Three formulations were prepared by the emulsion/solvent evaporation method. The nanocapsules showed a mean size distribution around 400 nm, with polydispersity below 0.2 and were stable for 120 days. Cytotoxicity and genotoxicity results showed an increase in toxicity of the oleic acid + neem formulations according to the amount of oleic acid used. The minimum inhibitory concentrations demonstrated that all the formulations containing neem oil were active...
July 19, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28724725/protein-diversity-in-discrete-structures-at-the-distal-tip-of-the-trypanosome-flagellum
#5
Vladimir Varga, Flavia Moreira-Leite, Neil Portman, Keith Gull
The distal end of the eukaryotic flagellum/cilium is important for axonemal growth and signaling and has distinct biomechanical properties. Specific flagellum tip structures exist, yet their composition, dynamics, and functions are largely unknown. We used biochemical approaches to identify seven constituents of the flagella connector at the tip of an assembling trypanosome flagellum and three constituents of the axonemal capping structure at the tips of both assembling and mature flagella. Both tip structures contain evolutionarily conserved as well as kinetoplastid-specific proteins, and component assembly into the structures occurs very early during flagellum extension...
July 19, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28722578/study-of-the-salivary-glands-in-triatominae-hemiptera-reduviidae-triatominae-their-color-and-application-to-the-chagas-disease-vector-evolution
#6
Jader de Oliveira, Amanda Ravazi, Eder Dos Santos Souza, Felipe Ferraz Figueiredo Moreira, Cleber Galvão, João Aristeu da Rosa, Kaio Cesar Chaboli Alevi
Chagas disease is caused by Trypanosoma cruzi and transmitted by feces of a triatomine that has the habit of defecating during blood feeding. The salivary glands of triatomines are important to hematophagy because their saliva is rich in anticoagulant and hemolytic proteins. The salivary glands of some Rhodnius species analyzed are reddish due to the presence of nitrophorins (antihemostatic activity). The present study aimed to analyze the color pattern of the salivary glands of 67 triatomine species to evaluate whether the presence of nitrophorins is a synapomorphy of Rhodnius or the tribe Rhodniini, or if it is shared with triatomines of the tribes Triatomini and Cavernicolini...
July 10, 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/28721124/association-between-exercise-induced-pulmonary-hemorrhage-and-inflammatory-airway-disease-in-polo-ponies
#7
Katia Moreira da Silva, Juliana Nabuco Pereira Otaka, Carlos Alexandre Paula Gonçalves, Estevão Grossi Aguiar Silva, Nayro Xavier de Alencar, Daniel Augusto Barroso Lessa
The respiratory system is essential for health and high athletic performance in horses. Respiratory diseases have been recognized as having a major impact on training equine animals and are commonly cited as the second most common cause of wasted training time. Inflammatory airway disease (IAD) is an important cause of poor performance in young racehorses. Exercise-induced pulmonary hemorrhage (EIPH) is considered a major issue for the equine industry because of its high prevalence and association with reduced athletic performance...
2017: Journal of Equine Science
https://www.readbyqxmd.com/read/28720442/impact-of-baseline-covariates-on-the-immunogenicity-of-the-9-valent-hpv-vaccine-a-combined-analysis-of-five-phase-iii-clinical-trials
#8
Lone K Petersen, Jaime Restrepo, Edson D Moreira, Ole-Erik Iversen, Punnee Pitisuttithum, Pierre Van Damme, Elmar A Joura, Sven-Erik Olsson, Daron Ferris, Stan Block, Anna R Giuliano, Xavier Bosch, Sophie Pils, Jack Cuzick, Suzanne M Garland, Warner Huh, Susanne K Kjaer, Oliver M Bautista, Donna Hyatt, Roger Maansson, Erin Moeller, Hong Qi, Christine Roberts, Alain Luxembourg
BACKGROUND: The immunogenicity profile of the 9-valent HPV (9vHPV) vaccine was evaluated across five phase III clinical studies conducted in girls and boys 9-15 years of age and young women 16-26 years of age. The effect of baseline characteristics of subjects on vaccine-induced HPV antibody responses was assessed. METHODS: Immunogenicity data from 11,304 subjects who received ≥1 dose of 9vHPV vaccine in five Phase III studies were analyzed. Vaccine was administered as a 3-dose regimen...
June 2017: Papillomavirus Research
https://www.readbyqxmd.com/read/28719887/anesthetic-management-of-cytoreductive-surgery-and-hyperthermic-intraperitoneal-chemotherapy-crs-hipec-the-importance-of-hydro-electrolytic-and-acid-basic-control
#9
Fabrício Tavares Mendonça, Marília Moreira Guimarães, Sérgio Honorato de Matos, Rúbia Garcia Dusi
JUSTIFICATION AND OBJECTIVES: Patients affected by gynecological or gastrointestinal tract neoplasms that evolve to peritoneal carcinomatosis experience a significant drop in their quality of life, high morbidity and short survival times with currently available chemotherapeutic schemes. The surgical treatment based on cytoreduction and the employment of hyperthermic intraperitoneal chemotherapy in the intra-operative period is a true challenge to anesthesiologist. CASE REPORT: A 67 years old patient diagnosed with mucinous adenocarcinoma of the Appendix associated with mucinous carcinomatosis, was submitted to cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC), under general anesthesia and epidural block...
July 10, 2017: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/28719808/activated-neuro-oxidative-and-neuro-nitrosative-pathways-at-the-end-of-term-are-associated-with-inflammation-and-physio-somatic-and-depression-symptoms-while-predicting-outcome-characteristics-in-mother-and-baby
#10
Chutima Roomruangwong, Decio Sabbatini Barbosa, Andressa Keiko Matsumoto, André de Souza Nogueira, Buranee Kanchanatawan, Sunee Sirivichayakul, André F Carvalho, Sebastien Duleu, Michel Geffard, Estefania Gastaldello Moreira, Michael Maes
OBJECTIVES: To examine oxidative & nitrosative stress (O&NS) biomarkers at the end of term in relation to perinatal affective symptoms, neuro-immune biomarkers and pregnancy-related outcome variables. METHODS: We measured plasma advanced oxidation protein products (AOPP), nitric oxide metabolites (NOx), total radical trapping antioxidant parameter (TRAP), -sulfhydryl (-SH), peroxides (LOOH) and paraoxonase (PON)1 activity in pregnant women with and without prenatal depression and non-pregnant controls...
July 6, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28718686/kinetic-study-on-the-inhibition-of-xanthine-oxidase-by-acylated-derivatives-of-flavonoids-synthesised-enzymatically
#11
Maria Elisa Melo Branco de Araújo, Yollanda Edwirges Moreira Franco, Thiago Grando Alberto, Marcia Cristina Fernandes Messias, Camila Wielewski Leme, Alexandra Christine Helena Frankland Sawaya, Patricia de Oliveira Carvalho
Studies have reported that flavonoids inhibit xanthine oxidase (XO) activity; however, poor solubility and stability in lipophilic media limit their bioavailability and applications. This study evaluated the kinetic parameters of XO inhibition and partition coefficients of flavonoid esters biosynthesised from hesperidin, naringin, and rutin via enzymatic acylation with hexanoic, octanoic, decanoic, lauric, and oleic acids catalysed by Candida antarctica lipase B (CALB). Quantitative determination by ultra-high performance liquid chromatography-mass spectrometry (UHPLC-MS) showed higher conversion yields (%) for naringin and rutin esters using acyl donors with 8C and 10C...
December 2017: Journal of Enzyme Inhibition and Medicinal Chemistry
https://www.readbyqxmd.com/read/28716627/membrane-proteins-structures-a-review-on-computational-modeling-tools
#12
REVIEW
Jose G Almeida, Antonio J Preto, Panagiotis I Koukos, Alexandre M J J Bonvin, Irina S Moreira
BACKGROUND: Membrane proteins (MPs) play diverse and important functions in living organisms. They constitute 20% to 30% of the known bacterial, archaean and eukaryotic organisms' genomes. In humans, their importance is emphasized as they represent 50% of all known drug targets. Nevertheless, experimental determination of their three-dimensional (3D) structure has proven to be both time consuming and rather expensive, which has led to the development of computational algorithms to complement the available experimental methods and provide valuable insights...
July 14, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28716097/regression-of-multifocoal-in-transit-melanoma-metastases-after-palliative-resection-of-dominant-masses-and-2%C3%A2-years-after-treatment-with-ipilimumab
#13
Raphael B Moreira, Lana Hamieh, Evisa Gjini, Ana Lako, Katherine M Krajewski, Charles H Yoon, Patrick A Ott
BACKGROUND: Spontaneous regression of metastatic melanoma and delayed responses more than one year after treatment with ipilimumab are rarely seen. CASE PRESENTATION: Here, we present the case of a patient with in transit metastases from cutaneous melanoma on his right lower extremity who achieved complete regression of all metastatic lesions 13 months after the first of two consecutive palliative resections of dominant masses and more than two years after treatment with ipilimumab...
July 18, 2017: Journal for Immunotherapy of Cancer
https://www.readbyqxmd.com/read/28715527/screening-criteria-for-ophthalmic-manifestations-of-congenital-zika-virus-infection
#14
Andrea A Zin, Irena Tsui, Julia Rossetto, Zilton Vasconcelos, Kristina Adachi, Stephanie Valderramos, Umme-Aiman Halai, Marcos Vinicius da Silva Pone, Sheila Moura Pone, Joel Carlos Barros Silveira Filho, Mitsue S Aibe, Ana Carolina C da Costa, Olivia A Zin, Rubens Belfort, Patricia Brasil, Karin Nielsen-Saines, Maria Elisabeth Lopes Moreira
Importance: Current guidelines recommend screening eye examinations for infants with microcephaly or laboratory-confirmed Zika virus infection but not for all infants potentially exposed to Zika virus in utero. Objective: To evaluate eye findings in a cohort of infants whose mothers had polymerase chain reaction-confirmed Zika virus infection during pregnancy. Design, Setting, and Participants: In this descriptive case series performed from January 2 through October 30, 2016, infants were examined from birth to 1 year of age by a multidisciplinary medical team, including a pediatric ophthalmologist, from Fernandes Figueira Institute, a Ministry of Health referral center for high-risk pregnancies and infectious diseases in children in Rio de Janeiro, Brazil...
July 17, 2017: JAMA Pediatrics
https://www.readbyqxmd.com/read/28714798/foot-rollover-temporal-parameters-during-walking-straight-ahead-and-stepping-over-obstacles-obese-and-non-obese-postmenopausal-women
#15
David Silva, Ronaldo Gabriel, Helena Moreira, João Abrantes, Aurélio Faria
The aim of this study was to compare the temporal foot rollover data between walking straight ahead and stepping over obstacles for obese and non-obese postmenopausal women. Plantar pressure data were collected from 67 women. The initial, final, and duration of contact of 10 foot areas were measured. Both limbs of both groups showed a longer foot contact duration on the obstacle task. Significant temporal differences were found for both groups between straight ahead and crossing obstacles on the initial, final, and duration of contact for several foot areas...
July 17, 2017: Journal of Aging and Physical Activity
https://www.readbyqxmd.com/read/28712941/rituximab-biosimilar-and-reference-rituximab-in-patients-with-previously-untreated-advanced-follicular-lymphoma-assist-fl-primary-results-from-a-confirmatory-phase-3-double-blind-randomised-controlled-study
#16
Wojciech Jurczak, Ilídia Moreira, Govind Babu Kanakasetty, Eduardo Munhoz, Maria Asunción Echeveste, Pratyush Giri, Nelson Castro, Juliana Pereira, Luiza Akria, Sergey Alexeev, Eugeniy Osmanov, Peijuan Zhu, Siyka Alexandrova, Angela Zubel, Olof Harlin, Jutta Amersdorffer
BACKGROUND: GP2013 is a rituximab biosimilar developed to stringent development guidelines, including non-clinical and preclinical investigations and clinical trials in rheumatoid arthritis and follicular lymphoma. We aimed to compare the efficacy, safety, tolerability, pharmacokinetics, and pharmacodynamics of GP2013 plus cyclophosphamide, vincristine, and prednisone (GP2013-CVP) with rituximab-CVP (R-CVP) in patients with follicular lymphoma. METHODS: In this phase 3, multinational, double-blind, randomised, controlled trial, adults (aged 18 years or older) with previously untreated, advanced stage (Ann Arbor stage III or IV) follicular lymphoma of WHO histological grades 1, 2, or 3a were randomly assigned (1:1) using interactive response technology to eight cycles of GP2013-CVP or R-CVP (combination phase), followed by monotherapy maintenance in responders for a 2-year period...
July 13, 2017: Lancet Haematology
https://www.readbyqxmd.com/read/28711955/the-effect-of-early-feeding-practices-on-growth-indices-and-obesity-at-preschool-children-from-four-european-countries-and-uk-schoolchildren-and-adolescents
#17
George Moschonis, Blandine de Lauzon-Guillain, Louise Jones, Andreia Oliveira, Christina-Paulina Lambrinou, Louiza Damianidi, Sandrine Lioret, Pedro Moreira, Carla Lopes, Pauline Emmett, Marie Aline Charles, Yannis Manios
Not only healthy growth but also childhood obesity partly originate from early life. The current work aimed to examine the association of feeding practices during infancy with growth and adiposity indices in preschool children from four European countries and in UK schoolchildren and adolescents. Existing data from four European birth cohorts (ALSPAC-UK, EDEN-France, EuroPrevall-Greece and Generation XXI-Portugal) were used. Anthropometrics and body composition indices were collected. Parallel multivariate regression analyses were performed to examine the research hypothesis...
July 15, 2017: European Journal of Pediatrics
https://www.readbyqxmd.com/read/28711457/comparison-of-the-finger-feeding-versus-cup-feeding-methods-in-the-transition-from-gastric-to-oral-feeding-in-preterm-infants
#18
Cláudia M D Moreira, Regina P G V Cavalcante-Silva, Cristina I Fujinaga, Francine Marson
OBJECTIVES: To assess the finger-feeding technique when compared with the cup feeding method during the early stage of preterm infant feeding transition regarding milk loss, milk ingestion period, and complications. METHODS: Experimental, randomized, prospective study including 53 preterm infants with gestation age<37 weeks, clinically stable, and with a score of >28 points in the Oral Feeding Readiness Assessment Scale. The preterm babies were randomized to be included in the control group, which underwent the feeding transition using a cup or in the experimental group, which used the finger-feeding technique...
July 13, 2017: Jornal de Pediatria
https://www.readbyqxmd.com/read/28710952/indices-of-insulin-resistance-and-glucotoxicity-are-not-associated-with-bipolar-disorder-or-major-depressive-disorder-but-are-differently-associated-with-inflammatory-oxidative-and-nitrosative-biomarkers
#19
Kamila Landucci Bonifácio, Décio Sabbatini Barbosa, Estefânia Gastaldello Moreira, Carine Coneglian de Farias, Luciana Higachi, Alissana Ester Iakmiu Camargo, Janaina Favaro Soares, Heber Odebrecht Vargas, Sandra Odebrecht Vargas Nunes, Michael Berk, Seetal Dodd, Michael Maes
BACKGROUND: Insulin resistance (IR) is a key factor in diabetes mellitus, metabolic syndrome (MetS) and obesity and may occur in mood disorders and tobacco use disorder (TUD), where disturbances of immune-inflammatory, oxidative and nitrosative stress (IO&NS) pathways are important shared pathophysiological pathways. METHODS: This study aimed to a) examine IR and β-cell function as measured by the homeostasis model assessment of insulin resistance (HOMA-IR) and insulin sensitivity and β cell function (HOMA-B) and glucotoxicity (conceptualized as increased glucose levels versus lowered HOMA-B values) in 74 participants with major depressive disorder (MDD) and bipolar disorder, with and or without MetS and TUD, versus 46 healthy controls, and b) whether IR is associated with IO&NS biomarkers, including nitric oxide metabolites (NOx), lipid hydroperoxides (LOOH), plasma advanced oxidation protein products (AOPP), C-reactive protein (CRP), haptoglobin (Hp) and uric acid...
July 6, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28710665/physical-exercise-reduces-pyruvate-carboxylase-pcb-and-contributes-to-hyperglycemia-reduction-in-obese-mice
#20
Vitor Rosetto Muñoz, Rafael Calais Gaspar, Barbara Moreira Crisol, Guilherme Pedron Formigari, Marcella Ramos Sant'Ana, José Diego Botezelli, Rodrigo Stellzer Gaspar, Adelino S R da Silva, Dennys Esper Cintra, Leandro Pereira de Moura, Eduardo Rochete Ropelle, José Rodrigo Pauli
The present study evaluated the effects of exercise training on pyruvate carboxylase protein (PCB) levels in hepatic tissue and glucose homeostasis control in obese mice. Swiss mice were distributed into three groups: control mice (CTL), fed a standard rodent chow; diet-induced obesity (DIO), fed an obesity-inducing diet; and a third group, which also received an obesity-inducing diet, but was subjected to an exercise training protocol (DIO + EXE). Protocol training was carried out for 1 h/d, 5 d/wk, for 8 weeks, performed at an intensity of 60% of exhaustion velocity...
July 14, 2017: Journal of Physiological Sciences: JPS
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