keyword
MENU ▼
Read by QxMD icon Read
search

moreira

keyword
https://www.readbyqxmd.com/read/29223098/trisubstituted-barbiturates-and-thiobarbiturates-synthesis-and-biological-evaluation-as-xanthine-oxidase-inhibitors-antioxidants-antibacterial-and-anti-proliferative-agents
#1
Joana Figueiredo, João L Serrano, Eunice Cavalheiro, Leena Keurulainen, Jari Yli-Kauhaluoma, Vânia M Moreira, Susana Ferreira, Fernanda C Domingues, Samuel Silvestre, Paulo Almeida
Barbituric and thiobarbituric acid derivatives have become progressively attractive to medicinal chemists due to their wide range of biological activities. Herein, different series of 1,3,5-trisubstituted barbiturates and thiobarbiturates were prepared in moderate to excellent yields and their activity as xanthine oxidase inhibitors, antioxidants, antibacterial agents and as anti-proliferative compounds was evaluated in vitro. Interesting bioactive barbiturates were found namely, 1,3-dimethyl-5-[1-(2-phenylhydrazinyl)ethylidene]pyrimidine-2,4,6(1H,3H,5H)-trione (6c) and 1,3-dimethyl-5-[1-[2-(4-nitrophenyl)hydrazinyl]ethylidene]pyrimidine-2,4,6(1H,3H,5H)-trione (6e), which showed concomitant xanthine oxidase inhibitory effect (IC50 values of 24...
November 27, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29220553/isomeric-column-forming-esters-and-imides-with-varying-curvatures-of-the-aromatic-plane
#2
Marli Ferreira, Thamires S Moreira, Rodrigo Cristiano, Hugo Gallardo, Ahmed Bentaleb, Pierre Dechambenoit, Elizabeth A Hillard, Fabien Durola, Harald Reinhart Bock
Dibenzo[a,j]coronene-tetracarboxylic alkyl esters and imides with either a centrosymmetric bis-peri substitution pattern or a polar bis-ortho substitution pattern form hexagonal columnar mesophases, which in the case of the imides persist at room temperature. The bis-peri isomers are obtained via a two-fold oxidative photocyclization; the bis-ortho isomers are accessed via a glyoxylic Perkin reaction of triphenylene and naphthalene building blocks. Steric congestion between the substituents and the adjacent benzo protrusion in the bis-ortho esters and imides leads to bending of the aromatic plane, which thus avoids twisting...
December 8, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/29220296/carcinosarcomas-and-related-cancers-tumors-caught-in-the-act-of-epithelial-mesenchymal-transition
#3
Angela Pang, Mariana Carbini, Andre L Moreira, Robert G Maki
In this review, we outline the biology and management of patients with carcinosarcomas and related malignancies, which are often included under the broader concept of sarcomatoid carcinomas. Carcinosarcomas are unusual tumors that are commonly gynecologic in origin, where they are referred to as malignant mixed Müllerian tumors, but may appear in any anatomic site. Although a variety of hypotheses have been presented as to the biphasic nature of these tumors, carcinosarcomas seem to represent the best example in human cancers of the concept of epithelial-mesenchymal transition (EMT), in which the two parts of the tumor are genomically related to one another, as opposed to the mesenchymal component that represents a second neoplasm or (benign) reactive process...
December 8, 2017: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/29219181/exercise-increases-rho-kinase-activity-and-insulin-signaling-in-skeletal-muscle
#4
Vitor Rosetto Muñoz, Rafael Calais Gaspar, Gabriel Keine Kuga, Alisson Luiz da Rocha, Barbara Moreira Crisol, José Diego Botezelli, Igor Luchini Baptista, Rania A Mekary, Adelino Sanchez Ramos da Silva, Dennys Esper Cintra, Leandro Pereira de Moura, Eduardo Rochete Ropelle, José Rodrigo Pauli
The effects of physical exercise on insulin signaling and glycemic homeostasis are not yet fully understood. Recent findings elucidated the positive role of Rho-kinase (Rock) in increasing the glucose uptake through insulin receptor substrate-1 (IRS1) phosphorylation in the skeletal muscle. Here, we explored the effects of short-term exercise on Rock activity and insulin signaling. Fischer 344 rats (3 months old) were subjected to a short-term swimming exercise for 2 h per day for 5 days, with an overload corresponding to 1...
December 8, 2017: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/29217530/the-impact-of-smoking-and-tp53-mutations-in-lung-adenocarcinoma-patients-with-targetable-mutations-the-lung-cancer-mutation-consortium-lcmc2
#5
Dara L Aisner, Lynette M Sholl, Lynne Berry, Michael Rossi, Heidi Chen, Junya Fujimoto, Andre L Moreira, Suresh Ramalingam, Liza C Villaruz, Gregory A Otterson, Eric B Haura, Katerina Politi, Bonnie S Glisson, Jeremy Cetnar, Edward Garon, Joan Schiller, Saiama Waqar, Lecia V Sequist, Julie R Brahmer, Yu Shyr, Kelly Kugler, Ignacio Ivan Wistuba, Bruce E Johnson, John D Minna, Mark G Kris, Paul A Bunn, David J Kwiatkowski
PURPOSE Multiplex genomic profiling is standard of care for patients with advanced lung adenocarcinomas. The Lung Cancer Mutation Consortium (LCMC) is a multi-institutional effort to identify and treat oncogenic driver events in patients with lung adenocarcinomas. PATIENTS AND METHODS Sixteen U.S. institutions enrolled 1367 lung cancer patients in LCMC2; 904 were deemed eligible and had at least one of 14 cancer-related genes profiled using validated methods including genotyping, massively parallel sequencing, and immunohistochemistry...
December 7, 2017: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/29217418/molecular-characterization-of-virulence-and-antimicrobial-resistance-profile-of-shigella-species-isolated-from-children-with-moderate-to-severe-diarrhea-in-northeastern-brazil
#6
Pedro Henrique Quintela Soares Medeiros, Aldo Ângelo Moreira Lima, Marjorie Moreira Guedes, Alexandre Havt, Mariana Duarte Bona, Luís Carlos Rey, Alberto Melo Soares, Richard Littleton Guerrant, Bernhard H Weigl, Ila Fernanda Nunes Lima
Molecular characterization of virulence and antimicrobial resistance profiles were determined for Shigella species isolated from children with diarrhea in Fortaleza, Brazil. Fecal specimens were collected along with socioeconomic and clinical data from children with moderate to severe diarrhea requiring emergency care. Shigella spp. were isolated by standard microbiological techniques, and we developed 4 multiplex polymerase chain reaction assays to detect 16 virulence-related genes (VRGs). Antimicrobial susceptibility tests were performed using disk diffusion assays...
November 10, 2017: Diagnostic Microbiology and Infectious Disease
https://www.readbyqxmd.com/read/29216785/orbit-score-an-useful-predictor-of-small-bowel-rebleeding-in-patients-under-chronic-anticoagulation
#7
Tiago Cúrdia Gonçalves, Cátia Arieira, Sara Monteiro, Bruno Rosa, Maria João Moreira, José Cotter
BACKGROUND AND STUDY AIMS: Available scoring systems to assess the risk for major bleeding in patients on chronic anticoagulation seem inadequate in predicting higher diagnostic yields of small bowel capsule endoscopy (SBCE) or higher rebleeding rates in patients with suspected small bowel bleeding. The aim of this study was to evaluate the ability of the new ORBIT score in predicting positive findings of SBCE or higher rebleeding rates in chronically anticoagulated patients with suspected small bowel bleeding...
December 7, 2017: Scandinavian Journal of Gastroenterology
https://www.readbyqxmd.com/read/29215714/photobiomodulation-of-mesenchymal-stem-cells-encapsulated-in-an-injectable-rhbmp4-loaded-hydrogel-directs-hard-tissue-bioengineering
#8
Ivana Márcia Alves Diniz, Ana Cláudia O Carreira, Carla Renata Sipert, Cindi Mie Uehara, Maria Stella Nunes Moreira, Laila Freire, Cibele Pelissari, Patrícia M Kossugue, Daniele Ribeiro de Araújo, Mari Cleide Sogayar, Márcia Martins Marques
Photobiomodulation (PBM) therapy displays relevant properties for tissue healing and regeneration, which may be of interest for the tissue engineering field. Here, we show that PBM is able to improve cell survival and to interact with recombinant human Bone Morphogenetic Protein 4 (rhBMP4) to direct and accelerate odonto/osteogenic differentiation of dental derived mesenchymal stem cells (MSCs). MSCs were encapsulated in an injectable and thermo-responsive cell carrier (Pluronic® F-127) loaded with rhBMP4 and then photoactivated...
December 7, 2017: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/29215686/are-desensitizing-toothpastes-equally-biocompatible-and-effective-against-microorganisms
#9
Samira Esteves Afonso Camargo, Noala Vicensoto Moreira Milhan, Fernanda de Oliveira Saraiva, Jonatas Rafael de Oliveira, Luciane Dias de Oliveira, Carlos Henrique Ribeiro Camargo
The aims of this study were evaluate cytotoxicity, genotoxicity, antimicrobial activity of desensitizing toothpastes compared to a common one and the surface roughness of tooth enamel submitted to brushing with these toothpastes. Samples of three desensitizing toothpastes (Colgate Sensitive, Sensodyne and Oral B Sensitive) and common toothpaste (Colgate) were placed in contact with gingival human fibroblasts. Cytotoxicity and genotoxocity were measured by MTT assay and micronucleus test. Antimicrobial activity of the toothpastes extracts against C...
September 2017: Brazilian Dental Journal
https://www.readbyqxmd.com/read/29213496/effects-of-a-cognitive-training-program-and-sleep-hygiene-for-executive-functions-and-sleep-quality-in-healthy-elderly
#10
Katie Moraes de Almondes, Maria Emanuela Matos Leonardo, Ana Maria Souza Moreira
Introduction: The aging process causes changes in the sleep-wake cycle and cognition, especially executive functions. Interventions are required to minimize the impact of the losses caused by the aging process. Objective: To evaluate the effects of a cognitive training program and psychoeducation on sleep hygiene techniques for executive functions and sleep quality in healthy elderly. Methods: The participants were 41 healthy elderly randomized into four groups ([CG] control group, cognitive training group [CTG], sleep hygiene group [SHG] and cognitive training and hygiene group [THG])...
January 2017: Dementia & Neuropsychologia
https://www.readbyqxmd.com/read/29213074/galectin-3-impacts-cryptococcus-neoformans-infection-through-direct-antifungal-effects
#11
Fausto Almeida, Julie M Wolf, Thiago Aparecido da Silva, Carlos M DeLeon-Rodriguez, Caroline Patini Rezende, André Moreira Pessoni, Fabrício Freitas Fernandes, Rafael Silva-Rocha, Roberto Martinez, Marcio L Rodrigues, Maria Cristina Roque-Barreira, Arturo Casadevall
Cryptococcus neoformans is an encapsulated fungal pathogen that causes cryptococcosis, which is a major opportunistic infection in immunosuppressed individuals. Mammalian β-galactoside-binding protein Galectin-3 (Gal-3) modulates the host innate and adaptive immunity, and plays significant roles during microbial infections including some fungal diseases. Here we show that this protein plays a role also in C. neoformans infection. We find augmented Gal-3 serum levels in human and experimental infections, as well as in spleen, lung, and brain tissues of infected mice...
December 6, 2017: Nature Communications
https://www.readbyqxmd.com/read/29211620/safety-profile-of-the-9-valent-human-papillomavirus-vaccine-assessment-in-prior-quadrivalent-hpv-vaccine-recipients-and-in-men-16-to-26%C3%A2-years-of-age
#12
E D Moreira, A R Giuliano, J de Hoon, O-E Iversen, E A Joura, J Restrepo, P Van Damme, C Vandermeulen, M C Ellison, A Krick, C Shields, B Heiles, A Luxembourg
A 9-valent HPV (9vHPV) vaccine has been developed to protect against HPV type 6/11/16/18/31/33/45/52/58-related infection and disease. Previous safety analyses from 7 clinical trials conducted in 9vHPV vaccine recipients 9-26 years of age, including comparisons of 9vHPV and quadrivalent HPV (qHPV) vaccines in girls and women 16-26 years of age, showed that the 9vHPV vaccine was generally well tolerated. Additional safety analyses were conducted to include the results of new clinical studies. The safety profile of the 9vHPV vaccine in prior qHPV vaccine recipients (n=3756 from 1 randomized controlled trial and 2 open-label extension studies) and young men (n=248 9vHPV and n=248 qHPV vaccine recipients from 1 randomized controlled trial) was evaluated...
December 6, 2017: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/29211242/potentially-pathogenic-acanthamoeba-genotype-t4-isolated-from-dental-units-and-emergency-combination-showers
#13
Esteban Castro-Artavia, Lissette Retana-Moreira, Jacob Lorenzo-Morales, Elizabeth Abrahams-Sandí
BACKGROUND: Acanthamoeba is the genus of free-living amoebae that is most frequently isolated in nature. To date, 20 Acanthamoeba genotypes have been described. Genotype T4 is responsible for approximately 90% of encephalitis and keratitis cases. Due to the ubiquitous presence of amoebae, isolation from environmental sources is not uncommon; to determine the clinical importance of an isolation, it is necessary to have evidence of the pathogenic potential of amoebae. OBJECTIVE: The aim of this study was to physiologically characterise 8 Acanthamoeba T4 isolates obtained from dental units and emergency combination showers and to determine their pathogenic potential by employing different laboratory techniques...
December 2017: Memórias do Instituto Oswaldo Cruz
https://www.readbyqxmd.com/read/29211241/parenteral-adjuvant-potential-of-recombinant-b-subunit-of-escherichia-coli-heat-labile-enterotoxin
#14
Carlos Eduardo Pouey da Cunha, Clóvis Moreira, Andréa da Silva Ramos Rocha, Paula Fonseca Finger, Carolina Georg Magalhães, Marcos Roberto Alves Ferreira, Odir Antônio Dellagostin, Ângela Nunes Moreira, Fabricio Rochedo Conceição
BACKGROUND: The B subunit of Escherichia coli heat-labile enterotoxin (LTB) is a potent mucosal immune adjuvant. However, there is little information about LTB's potential as a parenteral adjuvant. OBJECTIVES: We aimed at evaluating and better understanding rLTB's potential as a parenteral adjuvant using the fused R1 repeat of Mycoplasma hyopneumoniae P97 adhesin as an antigen to characterise the humoral immune response induced by this construct and comparing it to that generated when aluminium hydroxide is used as adjuvant instead...
December 2017: Memórias do Instituto Oswaldo Cruz
https://www.readbyqxmd.com/read/29211213/hybrid-treatment-with-complete-transposition-of-supra-aortic-trunks-versus-conventional-surgery-for-the-treatment-of-aortic-arch-aneurysm
#15
Leonardo de Oliveira Souza, Rodrigo de Castro Bernardes, Túlio Pinho Navarro, Ricardo Jayme Procópio, Fernando Antônio Roquete Reis, Luiz Claudio Moreira Lima, Ernesto Lentz da Silveira
OBJECTIVE: The disease of the aortic arch is traditionally approached by open surgical repair requiring cardiopulmonary bypass and circulatory arrest. This study performed a retrospective analysis comparing outcomes through primary hybrid patients submitted to aortic arch surgery without cardiopulmonary bypass with patients submitted to conventional open surgery. METHODS: 25 patients submitted to the aortic arch surgery were selected in the period 2003-2012 at the Madre Teresa Hospital in the city of Belo Horizonte, Brazil; 13 of these underwent hybrid technique without cardiopulmonary bypass and 12 underwent conventional open surgery...
September 2017: Brazilian Journal of Cardiovascular Surgery
https://www.readbyqxmd.com/read/29211209/risk-and-protection-factors-for-self-reported-hypertension-and-diabetes-in-jo%C3%A3-o-pessoa-brazil-the-vigitel-survey-2014-a-cross-sectional-study
#16
Ana Paula Leite Moreira, Deborah Carvalho Malta, Rodrigo Pinheiro de Toledo Vianna, Patrícia Vasconcelos Leitão Moreira, Alice Teles de Carvalho
CONTEXT AND OBJECTIVE: Chronic diseases are the main cause of death among adults and are responsible for most outpatient and hospital care expenses in Brazil. The objective here was to determine the prevalence of hypertension and diabetes and to analyze the associations with risk and protection factors among adults. DESIGN AND LOCAL: Cross-sectional study in a state capital in northeastern Brazil. METHODS: Data on adults of both sexes aged ≥ 45 years who were interviewed in the Vigitel telephone survey in 2014 were analyzed...
September 2017: São Paulo Medical Journal, Revista Paulista de Medicina
https://www.readbyqxmd.com/read/29211194/telephone-interventions-in-adherence-to-receiving-the-pap-test-report-a-randomized-clinical-trial
#17
Ana Izabel Oliveira Nicolau, Thaís Marques Lima, Camila Teixeira Moreira Vasconcelos, Francisco Herlânio Costa Carvalho, Priscila de Souza Aquino, Ana Karina Bezerra Pinheiro
OBJECTIVE: to test the efficacy of the behavioral and educational interventions undertaken by telephone, for women's attendance at the consultation to receive the Pap test report. METHOD: a randomized clinical trial, with a sample randomized in three groups: telephone call - educational (n=171), telephone call - reminder (n=171) and comparison (n=169). The inclusion criteria were to be of legal age, to have become sexually active, to undertake the preventive examination during the study and to have a mobile or fixed telephone...
December 4, 2017: Revista Latino-americana de Enfermagem
https://www.readbyqxmd.com/read/29211179/survival-analysis-of-women-with-breast-cancer-competing-risk-models
#18
Rosemeire de Olanda Ferraz, Djalma de Carvalho Moreira-Filho
This study aimed to estimate the effects of prognostic factors on breast cancer survival, such as age, staging, and extension of the tumor, using proportional hazards and competing risks models proposed by Cox and Fine-Gray, respectively. This is a retrospective cohort study, based on a population of 524 women, who were diagnosed with breast cancer in the period from 1993 to 1995 and monitored until 2011, residents in the city of Campinas, São Paulo, Brazil. The cutoff points for the variable of age were defined with Cox simple models...
November 2017: Ciência & Saúde Coletiva
https://www.readbyqxmd.com/read/29211169/artisanal-fisherwomen-shellfish-gatherers-analyzing-the-impact-of-upper-limb-functioning-and-disability-on-health-related-quality-of-life
#19
Juliana Dos Santos Müller, Ila Rocha Falcão, Maria Carolina Barreto Moreira Couto, Wendel da Silva Viana, Ivone Batista Alves, Denise Nunes Viola, Courtney Georgette Woods, Rita de Cássia Franco Rêgo
The aim is to analyze upper limb functioning and disability, and its association with health-related quality of life among artisanal fisherwomen from Bahia, Brazil. Cross-sectional epidemiological study was conducted with a sample of 209 fisherwomen. Structured questionnaires were used for socio-demographic and comorbidity information, as well as the instruments Disabilities of the Arm, Shoulder and Hand (DASH) and Short-Form Healthy Survey (SF-36) respectively, to evaluate the upper limbs and health-related quality of life...
November 2017: Ciência & Saúde Coletiva
https://www.readbyqxmd.com/read/29211136/surveillance-system-for-risk-and-protective-factors-for-chronic-diseases-by-telephone-survey-vigitel-changes-in-weighting-methodology
#20
Regina Tomie Ivata Bernal, Betine Pinto Moehlecke Iser, Deborah Carvalho Malta, Rafael Moreira Claro
OBJECTIVE: to introduce the methodology used to calculate post-stratification weights of the 2012 Surveillance System for Risk and Protective Factors for Chronic Diseases by Telephone Survey (Vigitel) and to compare the trends of indicators estimated by cell-by-cell weighting and raking methods. METHODS: in this panel of cross-sectional studies, the prevalences of smokers, overweight, and intake of fruits and vegetables from 2006 to 2012 were estimated using the cell-by-cell weighting and raking methods...
October 2017: Epidemiologia e Servicos de Saude: Revista do Sistema Unico de Saude do Brasil
keyword
keyword
62467
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"