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Vânia Stiepanowez de Oliveira Rocha, Solange da Silva Malfacini, Alex Moreira Gomes, Cláudia Ramos Marques da Rocha
OBJECTIVE:  To discuss the implementation and contributions of the External Quality Monitoring in the city of Rio de Janeiro and to analyze the performance of the main providers of cervical cytopathology in this city from September 2013 to March 2017, here referred to as "Alpha laboratory" and "Beta laboratory." METHODS:  Observational, cross-sectional, retrospective study using information from the Cervical Cancer Control Information System (SISCOLO, in the Portuguese acronym), municipal coordination module, External Quality Monitoring report...
June 20, 2018: Revista Brasileira de Ginecologia e Obstetrícia
Rafael I Ponce-Toledo, David Moreira, Purificación López-García, Philippe Deschamps
Endosymbiosis has been common all along eukaryotic evolution, providing opportunities for genomic and organellar innovation. Plastids are a prominent example. After the primary endosymbiosis of the cyanobacterial plastid ancestor, photosynthesis spread in many eukaryotic lineages via secondary endosymbioses involving red or green algal endosymbionts and diverse heterotrophic hosts. However, the number of secondary endosymbioses and how they occurred remain poorly understood. In particular, contrasting patterns of endosymbiotic gene transfer (EGT) have been detected and subjected to various interpretations...
June 19, 2018: Molecular Biology and Evolution
Rogerio Nabor Kondo, Isabela Peron Melhado, Cassio Rafael Moreira, Jefferson Crespigio
No abstract text is available yet for this article.
June 2018: Anais Brasileiros de Dermatologia
Andréa Carvalho Araújo Moreira, Maria Josefina da Silva, Juan José Tirado Darder, Janaína Fonseca Victor Coutinho, Maristela Inês Osawa Vasconcelos, Marília Braga Marques
OBJECTIVE: To compare the knowledge, attitude and practice of older adults' caregivers before and after an educational intervention in the domains of the care between caregiver and older adult, feeding, bathing, hygiene and mobility and transportation. METHOD: Quasi-experimental study carried out with 82 caregivers, of which 34 participated in the intervention. Interviews were conducted through a knowledge, attitude and practice research on the older adults` care Results: The educational intervention led to improvements in knowledge, attitude and practice, with statistical significance of attitude (p <0...
May 2018: Revista Brasileira de Enfermagem
Eline Saraiva Silveira Araújo, Lúcia de Fátima da Silva, Thereza Maria Magalhães Moreira, Paulo César de Almeida, Maria Célia de Freitas, Maria Vilani Cavalcante Guedes
OBJECTIVE: To verify the effectiveness of nursing interventions based on the Imogene King's Theory of Goal Attainment, on improving care for people with diabetes and adherence to treatment. METHOD: Quasi-experimental, longitudinal, randomized, simple study in a Primary Health Care Unit, in the city of Fortaleza, Ceará state, Brazil. The sample consisted of 60 people with diabetes, divided into intervention and control groups, whose collection occurred from February to August 2013...
May 2018: Revista Brasileira de Enfermagem
Kamilla Rodrigues Rogerio, Leonardo J M Carvalho, Luiza Helena Pinto Domingues, Bruno Junior Neves, José Teófilo Moreira Filho, Rosane Nora Castro, Cesare Bianco Júnior, Claudio Tadeu Daniel-Ribeiro, Carolina Horta Andrade, Cedric Stephan Graebin
BACKGROUND Malaria is responsible for 429,000 deaths per year worldwide, and more than 200 million cases were reported in 2015. Increasing parasite resistance has imposed restrictions to the currently available antimalarial drugs. Thus, the search for new, effective and safe antimalarial drugs is crucial. Heterocyclic compounds, such as dihydropyrimidinones (DHPM), synthesised via the Biginelli multicomponent reaction, as well as bicyclic compounds synthesised from DHPMs, have emerged as potential antimalarial candidates in the last few years...
2018: Memórias do Instituto Oswaldo Cruz
Daniel C Moreira, Alexis F Welker, Élida G Campos, Silvia Cristina R de Souza, Marcelo Hermes-Lima
Juvenile tegu lizards (Salvator merianae) experience gradual and mild temperature changes from autumn to winter in their habitat. This tropical/subtropical reptile enter a state of dormancy, with an 80% reduction in metabolic rate, that remains almost constant during winter. The redox metabolism in non-mammalian vertebrates that hibernate under such distinguished conditions is poorly understood. We analyzed the redox metabolism in the intestine of juvenile tegus during different stages of their first annual cycle...
June 19, 2018: Scientific Reports
Yuri Campelo, Alicia Ombredane, Andreanne G Vasconcelos, Lucas Albuquerque, Daniel C Moreira, Alexandra Plácido, Jefferson Rocha, Harold Hilarion Fokoue, Lydia Yamaguchi, Ana Mafud, Yvonne P Mascarenhas, Cristina Delerue-Matos, Tatiana Borges, Graziella A Joanitti, Daniel Arcanjo, Massuo J Kato, Selma A S Kuckelhaus, Marcos P N Silva, Josué de Moraes, José Roberto S A Leite
Schistosomiasis, caused by helminth flatworms of the genus Schistosoma , is an infectious disease mainly associated with poverty that affects millions of people worldwide. Since treatment for this disease relies only on the use of praziquantel, there is an urgent need to identify new antischistosomal drugs. Piplartine is an amide alkaloid found in several Piper species (Piperaceae) that exhibits antischistosomal properties. The aim of this study was to evaluate the structure⁻function relationship between piplartine and its five synthetic analogues (19A, 1G, 1M, 14B and 6B) against Schistosoma mansoni adult worms, as well as its cytotoxicity to mammalian cells using murine fibroblast (NIH-3T3) and BALB/cN macrophage (J774A...
June 19, 2018: International Journal of Molecular Sciences
Maximilian Reichert, Basil Bakir, Leticia Moreira, Jason R Pitarresi, Karin Feldmann, Lauren Simon, Kensuke Suzuki, Ravikanth Maddipati, Andrew D Rhim, Anna M Schlitter, Mark Kriegsmann, Wilko Weichert, Matthias Wirth, Kathleen Schuck, Günter Schneider, Dieter Saur, Albert B Reynolds, Andres J Klein-Szanto, Burcin Pehlivanoglu, Bahar Memis, N Volkan Adsay, Anil K Rustgi
The regulation of metastatic organotropism in pancreatic ductal a denocarcinoma (PDAC) remains poorly understood. We demonstrate, using multiple mouse models, that liver and lung metastatic organotropism is dependent upon p120catenin (p120ctn)-mediated epithelial identity. Mono-allelic p120ctn loss accelerates KrasG12D -driven pancreatic cancer formation and liver metastasis. Importantly, one p120ctn allele is sufficient for E-CADHERIN-mediated cell adhesion. By contrast, cells with bi-allelic p120ctn loss demonstrate marked lung organotropism; however, rescue with p120ctn isoform 1A restores liver metastasis...
June 18, 2018: Developmental Cell
Christian Giancarlo Bernal Rodriguez, Luciane Franco Kraul, Thales Wilson Cardoso, Carlos de Paula Eduardo, Ana Cecília Corrêa Aranha, Patrícia Moreira de Freitas
Several photobiomodulation (PBM) protocols with low-power lasers have been reported for pain control and tissue repair in the postoperative period of oral surgeries. However, there are still no reports of a protocol for bichectomy surgeries' postoperative period. Thus, this article presents six reports of clinical cases in which bichectomy surgery was performed. In the postoperative period, three patients were submitted to PBM with low-power lasers, while three patients did not receive it. Facial edema was evaluated using a millimeter tape...
June 19, 2018: Photomedicine and Laser Surgery
Pedro Jorge Cavalcante Costa, Johnny Holanda de Gauw, José Zenou Costa Filho, Raphael Teixeira Moreira, Paulo Domingos Ribeiro Júnior
Treatment of orbital fractures involves restoration of lost bone anatomy and orbital volume. Among the materials used for this purpose, the titanium mesh is widely used due to its effectiveness and low complication rate related to distortion especially in non-traumatic events. This study shows an atypical and late complication involving the deformation of the titanium mesh used during reconstruction of the orbital floor in a patient with orbital zygomatic complex fracture 5 months after the procedure and without traumatic etiology...
June 18, 2018: Journal of Craniofacial Surgery
Kurt Brorson, Beth Junker, Antonio Moreira, Anurag Rathore, Mia Ricci, Govind Rao
No abstract text is available yet for this article.
May 2018: PDA Journal of Pharmaceutical Science and Technology
Inês N Silva, Filipa D Pessoa, Marcelo J Ramires, Mário R Santos, Jörg D Becker, Vaughn S Cooper, Leonilde M Moreira
Bacteria from the Burkholderia cepacia complex grow in different natural and man-made environments and are feared opportunistic pathogens that cause chronic respiratory infections in cystic fibrosis patients. Previous studies showed that Burkholderia mucoid clinical isolates grown under stress conditions give rise to nonmucoid variants devoid of the exopolysaccharide cepacian. Here, we have determined that a major cause of the nonmucoid morphotype involves nonsynonymous mutations and small indels in the ompR gene encoding a response regulator of a two-component regulatory system...
June 18, 2018: Journal of Bacteriology
J M Aragonès, J Altimiras, F Alonso, G Celedón, S Alfonso, P Roura, A Moreira
INTRODUCTION: According to most studies, the incidence of Guillain-Barré syndrome increases with age, with a peak incidence occurring between 70 and 80 years of age. The objective of this study is to describe the incidence (overall and by sex and age group) and clinical characteristics of Guillain-Barré syndrome in Osona (Barcelona, Spain). METHODS: We performed a retrospective, descriptive, population-based study covering the period 2003 to 2016. RESULTS: The global incidence of Guillain-Barré syndrome is 2...
June 15, 2018: Neurología: Publicación Oficial de la Sociedad Española de Neurología
Adilson José DePina, El Hadji Amadou Niang, Alex Jailson Barbosa Andrade, Abdoulaye Kane Dia, Antonio Moreira, Ousmane Faye, Ibrahima Seck
BACKGROUND: Malaria, despite being preventable and treatable, continues to be a major public health problem worldwide. The archipelago nation of Cape Verde is in a malaria pre-elimination phase with the highest potential to achieve the target goal of elimination in 2020. METHODS: Nationwide malaria epidemiological data were obtained from the Cape Verde health information system that includes the individual malaria case notification system from all of the country's health structures...
June 19, 2018: Malaria Journal
Katia Ramos Moreira Leite, Thais Silva, Bruna Naum, Flavio Canavez, Juliana Canavez, Ruan Pimenta, Sabrina Reis, Luiz Heraldo Camara-Lopes
OBJECTIVE: To test the performance of a new fixative for pap smear collection for liquid-based cervical cytology, CellPreserv® and compare it with the commercially available, PreservCyt® used in the diagnosis and detection of human papillomavirus (HPV). METHODS: Seven hundred twenty five women participated in this study after signing an informed consent. The specimens were collected using a traditional device, agitated in PBS, and equally divided in both fixatives...
June 18, 2018: Acta Cytologica
Lázaro Moreira Marques Neto, Nicholas Zufelato, Ailton Antônio de Sousa-Júnior, Monalisa Martins Trentini, Adeliane Castro da Costa, Andris Figueiroa Bakuzis, André Kipnis, Ana Paula JunqueiraKipnis
Metal-based nanoparticles (NPs) stimulate innate immunity; however, they have never been demonstrated to be capable of aiding the generation of specific cellular immune responses. Therefore, our objective was to evaluate whether iron oxide-based NPs have adjuvant properties in generating cellular Th1, Th17 and TCD8 (Tc1) immune responses. For this purpose, a fusion protein (CMX) composed of Mycobacterium tuberculosis antigens was used as a subunit vaccine. Citrate-coated MnFe2 O4 NPs were synthesized by co-precipitation and evaluated by transmission electron microscopy...
June 18, 2018: Human Vaccines & Immunotherapeutics
Jolanda van der Velden, Carlo Gabriele Tocchetti, Gilda Varricchi, Anna Bianco, Vasco Sequeira, Denise Hilfiker-Kleiner, Nazha Hamdani, Adelino Leite-Moreira, Manuel Mayr, Ines Falcão-Pires, Thomas Thum, Dana K Dawson, Jean-Luc Balligand, Stephane Heymans
Disturbed metabolism as a consequence of obesity and diabetes may cause cardiac diseases (recently highlighted in the CVR spotlight issue on Metabolic cardiomyopathies).1 In turn, the metabolism of the heart may also be disturbed in genetic and acquired forms of hypertrophic cardiac disease. Here, we provide an overview of recent insights on metabolic changes in genetic hypertrophic cardiomyopathy (HCM) and discuss several therapies which may be explored to target disturbed metabolism and prevent onset of cardiac hypertrophy...
June 15, 2018: Cardiovascular Research
Rodrigo Fileto Gavaldão Moreira, Alexandre Yukio Nishimi, Enrico Montorsi Zanon, Thales Santos Rama, Rodrigo Pacheco Lessa Ciofi, Eiffel Tsuyoshi Dobashi
Objective: This study is aimed at determining, through a cross-sectional study, the preferred therapeutic method in Brazil considering the approach to Gartland type II and III supracondylar humerus fractures during childhood. Methods: The research project was approved by the Research Ethics Committee of Plataforma Brasil and the material was collected during the 46th Brazilian Orthopedics and Traumatology Congress. A questionnaire was developed to analyze two clinical scenarios about Gartland type II and III fractures...
March 2018: Revista Brasileira de Ortopedia
Luis M de Pablos Torró, Lissette Retana Moreira, Antonio Osuna
Extracellular vesicles (EVs) are small lipid vesicles released by prokaryotic and eukaryotic cells containing nucleic acids, proteins, and small metabolites essential for cellular communication. Depending on the targeted cell, EVs can act either locally or in distant tissues in a paracrine or endocrine cell signaling manner. Released EVs from virus-infected cells, bacteria, fungi, or parasites have been demonstrated to perform a pivotal role in a myriad of biochemical changes occurring in the host and pathogen, including the modulation the immune system...
2018: Frontiers in Microbiology
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