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Neurological soft signs

Rolfe M Radcliffe, Yasmine Messiaen, Nita L Irby, Thomas J Divers, Curtis W Dewey, Katharyn J Mitchell, Lauren V Schnabel, Abraham J Bezuidenhout, Peter V Scrivani, Norm G Ducharme
OBJECTIVE: To report a transnasal, endoscopically guided ventral surgical approach for accessing the cranial and caudal segments of the sphenopalatine sinus for mass removal in a horse. STUDY DESIGN: Case report. ANIMAL: Adult horse with acute onset blindness referable to a soft tissue mass within the sphenopalatine sinus. CLINICAL REPORT: A 7-year-old Warmblood gelding presented with a history of running into a fence and falling...
October 12, 2016: Veterinary Surgery: VS
Mariabernarda Pitzianti, Elisa D'Agati, Livia Casarelli, Marco Pontis, Ivo Kaunzinger, Klaus W Lange, Oliver Tucha, Paolo Curatolo, Augusto Pasini
INTRODUCTION: Inattention is one of the core symptoms of Attention Deficit Hyperactivity Disorder (ADHD). Most of patients with ADHD show motor impairment, consisting in the persistence of neurological soft signs (NSS). Our aim was to evaluate attentional and motor functioning in an ADHD sample and healthy children (HC) and possible link between attentional dysfunction and motor impairment in ADHD. METHOD: Twenty-seven drug-naive patients with ADHD and 23 HC were tested with a test battery, measuring different aspects of attention...
October 1, 2016: Cognitive Neuropsychiatry
Olivier Gay, Marion Plaze, Catherine Oppenheim, Raphael Gaillard, Jean-Pierre Olié, Marie-Odile Krebs, Arnaud Cachia
BACKGROUND: Several clinical and radiological markers of early neurodevelopmental deviations have been independently associated with cognitive impairment in patients with schizophrenia. The aim of our study was to test the cumulative and/or interactive effects of these early neurodevelopmental factors on cognitive control (CC) deficit, a core feature of schizophrenia. METHODS: We recruited patients with first-episode schizophrenia-spectrum disorders, who underwent structural MRI...
September 23, 2016: Journal of Psychiatry & Neuroscience: JPN
Aude Paquet, Bertrand Olliac, Manuel-Pierre Bouvard, Bernard Golse, Laurence Vaivre-Douret
BACKGROUND: Altered motor performance has been described in Autism Spectrum Disorders (ASD) with disturbances in walking; posture, coordination, or arm movements, but some individuals with ASD show no impairment of motor skills. The neuro-developmental processes that underpin the performance of neuro-psychomotor functions have not been widely explored, nor is it clear whether there are neuro-psychomotor functions specifically affected in ASD. Our objective was to focus on the semiology of motor disorders among children with ASD using a neuro-developmental assessment tool...
2016: Frontiers in Psychology
L Vaivre-Douret, A Boschi, M L Cuny, C Clouard, A Mosser, B Golse, A Philippe, M Bourgeois, N Boddaert, S Puget
: Left temporal arachnoid cyst and specific learning disorders associated with pervasive developmental disorders - not otherwise specified (PDD-NOS): contributions of an integrative neuro-psychomotor, neuropsychological, psychopathological and neurosurgical approach about a case report in a child (François). With DSM-IV and DSM-IV-TR, the terminology of pervasive developmental disorders (PDD) covers two main categories of infantile disorders: disorders of "strictly" autistic nature and pervasive developmental disorders - not otherwise specified (PDD-NOS)...
September 16, 2016: L'Encéphale
Simona Caldani, Maria Pia Bucci, Jean-Charles Lamy, Magali Seassau, Narjes Bendjemaa, Rémi Gadel, Raphael Gaillard, Marie-Odile Krebs, Isabelle Amado
Schizophrenia is a neurodevelopmental disease with cognitive and motor impairments. Motor dysfunctions, such as eye movements or Neurological Soft Signs (NSS), are proposed as endophenotypic markers. Antisaccade (AS) and memory-guided saccades (MGS), two markers of inhibitory control mechanism, are altered in both patients with schizophrenia and their relatives, although these tools may have different sensitivities. Recently, emphasis has been put on identifying markers predictive of psychosis transition in subjects with ultra-high-risk psychosis in order to develop targeted prevention...
September 14, 2016: Schizophrenia Research
Christine A Ho, David A Podeszwa, Anthony I Riccio, Robert L Wimberly, Brandon A Ramo
BACKGROUND: Neurovascular injury in pediatric supracondylar fractures (SCHFx) has been associated with fracture classification but not with soft tissue injury. The purpose of this study is to correlate clinical soft tissue damage to neurovascular injuries in SCHFx. METHODS: This is an institutional review board approved prospective study from January 2010 through December 2013 of 748 operatively treated pediatric SCHFx. Prospective data were gathered both preoperatively and intraoperatively regarding detailed neurovascular examination as well as soft tissue status, with qualitative descriptives for swelling (mild/moderate/severe), ecchymosis, abrasions, skin tenting, and skin puckering...
September 3, 2016: Journal of Pediatric Orthopedics
Chetali Vijay Dhuri, Shubhangi R Parkar
OBJECTIVE: Modern research on obsessive-compulsive disorder (OCD) indicates that the primary cause of OCD, which was earlier explained only on basis of psychoanalytical theories, is biological. Our study attempts to investigate the neurobiological signs in form of soft neurological signs and cognitive function in OCD. METHODS: A cross sectional study was conducted at psychiatric facility of Seth G.S. Medical College and KEM Hospital. MATERIALS AND METHOD: 50 OCD patients and age- and education-matched controls were selected for the study...
July 2016: Indian Journal of Psychological Medicine
Livia Casarelli, Maurizio Minnei, Mariabernarda Pitzianti, Marco Armando, Maria Pontillo, Stefano Vicari, Augusto Pasini
22q11 Deletion syndrome (22q11DS) is a neurogenetic disorder, resulting from a hemizygous microdeletion on the long arm of chromosome 22. In 22q11DS, the phenotypic expression is highly variable. Approximately one-third of all individuals with 22q11DS develop schizophrenia-like psychotic disorder. Among the genes in the deleted region, catechol-O-methyltransferase (COMT) has a particular relevance for psychiatric disorders: lower COMT enzymatic activity decreases the clearance of dopamine (DA), yielding higher levels of catecholamines in the central nervous system...
October 2016: Psychiatric Genetics
Mohammad Arbabi, Negin Paast, Hamid Reza Karim, Sara Faghfori, Amir Hossein Memari
The aim of the present study was to determine whether patients with borderline personality disorder (BPD) show any neurological soft signs compared to healthy controls. Furthermore we sought to examine the role of common symptoms related to BPD, such as depression, anxiety or impulsivity, in association with neurological soft signs. Thirty patients with borderline personality disorder and thirty hospital-based controls were examined for neurological soft signs. The total score of neurological soft signs in BPD was significantly higher than controls...
November 30, 2016: Psychiatry Research
Srikant Sharma, Triptish Bhatia, Sati Mazumdar, Smita N Deshpande
Both neurological soft signs (NSS) and cognitive deficits are present among euthymic bipolar patients. NSS could be related to neurocognitive performance, but this is not explored thoroughly. Healthy relatives of patients may also suffer from similar deficits. This study compared NSS and cognitive functions in euthymic Bipolar I Disorder (BPI) cases to their non-affected first degree relatives and healthy controls. We also investigated the association between NSS and cognitive functions in these three groups...
August 2016: Asian Journal of Psychiatry
Murali Uthamalingam, Dharamjit Singh Jitsweer Singh
Incidences of cerebral palsy (CP) in children are not quite common even though it is the most common motor disorder in children. Further quality of life in CP cases is not so good in young adult stages and has to face certain problems. However scalp haematoma formation in CP patient without injury to head is rarely been reported. The case is being reported for the first time from Malaysia. We report on a unique case of scalp haematoma in an 18-year-old girl of known CP patient with unknown cause. No history of trauma or fall with any of the focal neurological signs or symptoms was found...
June 2016: Journal of Clinical and Diagnostic Research: JCDR
Cinzia Galasso, Livia Casarelli, Nadia El Malhany, Maria B Pitzianti, Simonetta Spiridigliozzi, Paolo Curatolo, Augusto Pasini
BACKGROUND: Neurofibromatosis type 1 is a common neurogenetic disorder affecting nervous system, caused by germiline mutations of the NF1 gene. Although the clinical diagnosis of NF1 is defined by presence of cafe-au-laits spots, freckling and benign tumours (neurofibromatosis), neurocognitive impairment and neuropsychiatric disorders are reported in comorbidity. Children with NF1 show higher incidence of executive deficits, such attention, response inhibition, executive planning and problem solving, working memory, and learning impairment...
July 8, 2016: Minerva Pediatrica
Nijil L Vasukutty, Tahawwar Hasnat Ahmad Minhas
INTRODUCTION: Metal toxicity from metal-on-metal hip replacements is now well documented and several large series have reported local reactions. Although less common, there are reports of similar reactions from failed ceramic liners. Systemic effects documented in literature have been grouped into cardiac, neuro-ocular and thyroid signs. METHODS AND RESULTS: We report a case of a patient who had revision for fractured ceramic liner to metal on polyethylene. Third body effect of the ceramic particles led to wear through of the poly liner and the head directly articulating with metal shell...
2016: Hip International: the Journal of Clinical and Experimental Research on Hip Pathology and Therapy
Xin Wang, Lin Cai, Lingyan Li, Yanjie Yang, Xiongzhao Zhu
OBJECTIVE: Neurological soft signs (NSSs) may reflect neurodevelopmental anomalies in association with the spectrum of schizophrenia disorders. We examined NSSs in Chinese adolescents with schizophrenia and schizotypal personality traits. METHODS: Eighty-seven schizophrenic adolescents (SCH group), 85 adolescents with only schizotypal personality traits (SPT group), and 88 healthy controls (HC group) were enrolled. The NSS subscales of the Cambridge Neurological Inventory (CNI) were administered to all 260 participants...
October 2016: International Journal of Developmental Neuroscience
David E Newman-Toker, Charles C Della Santina, Ari M Blitz
Symptoms referable to disorders affecting the inner ear and vestibulocochlear nerve (eighth cranial nerve) include dizziness, vertigo, tinnitus, and hearing loss, in various combinations. Similar symptoms may occur with involvement of the central nervous system, principally the brainstem and cerebellum, to which the vestibular and auditory systems are connected. Imaging choices should be tailored to patient symptoms and the clinical context. Computed tomography (CT) should be used primarily to assess bony structures...
2016: Handbook of Clinical Neurology
Xin Wang, Lin Cai, Lingyan Li, Yanjie Yang, Shuqiao Yao, Xiongzhao Zhu
The current study was designed to explore the specific relationship between neurologic soft signs (NSSs) and characteristics of antisocial personality traits in adolescents, and to investigate particular NSSs linked to certain brain regions in adolescents with antisocial personality traits. The research was conducted on 96 adolescents diagnosed with ASP traits (ASP trait group) using the ASPD subscale of the Personality Diagnostic Questionnaire for the DSM-IV (PDQ-4+) and 96 adolescents without traits of any personality disorder (control group)...
September 30, 2016: Psychiatry Research
Mithun Dutta, Kamal Nath, Aparajeeta Baruah, Subrata Naskar
BACKGROUND AND AIM: Neurological soft signs (NSSs) are "objectively measured, nonlocalizing abnormalities, not related to impairment of a specific brain region, reflecting improper cortical-subcortical and intercortical connections." The possibility of NSS as an endophenotype in schizophrenia has been studied across the globe. We aimed at finding the prevalence of NSS among patients with schizophrenia as well as the associations of NSS between various sociodemographic and illness variables...
July 2016: Journal of Neurosciences in Rural Practice
S Halayem, M Hammami, R Fakhfakh, N Gaddour, K Tabbane, I Amado, M-O Krebs, A Bouden
BACKGROUND: Neurological soft signs (NSS) include anomalies in motor integration, coordination, sensory integration and lateralization and could be endophenotypic markers in autism spectrum disorders (ASD). Their characterization provides a more precise phenotype of ASD and more homogeneous subtypes to facilitate clinical and genetic research. Few scales for NSS have been adapted and validated in children including children with ASD. Our objective was to perform an adaptation to the child of a scale assessing neurological soft signs and a validation study in both general and clinical populations...
June 24, 2016: L'Encéphale
Henri-Arthur Leroy, Cristina Ioana Leroy-Ciocanea, Marc Baroncini, Philippe Bourgeois, Philippe Pellerin, Julien Labreuche, Alain Duhamel, Jean-Paul Lejeune
BACKGROUND: Internal variation among spheno-orbital meningiomas (SOM) is surgically challenging. Optic canal invasion management is discussed. METHOD: This retrospective study includes 70 patients with SOM who underwent surgery between 1995 and 2012. Preoperative ophthalmological, neurological and aesthetic clinical signs were collected. All patients benefitted from repeated tomography and magnetic resonance imaging (MRI). The surgical team consisted of a neurosurgeon and a plastic surgeon...
August 2016: Acta Neurochirurgica
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