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Neurological soft signs

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https://www.readbyqxmd.com/read/28095336/psychiatric-symptoms-mediate-the-effects-of-neurological-soft-signs-on-functional-outcomes-in-patients-with-chronic-schizophrenia-a-longitudinal-path-analytic-study
#1
Ted C T Fong, Rainbow T H Ho, Adrian H Y Wan, Friendly S W Au-Yeung
Neurological soft signs (NSS) in motor coordination and sequencing occur in schizophrenia patients and are an intrinsic sign of the underlying neural dysfunctions. The present longitudinal study explored the relationships among NSS, psychiatric symptoms, and functional outcomes in 151 Chinese patients with chronic schizophrenia across a 6-month period. The participants completed neurological assessments at baseline (Time 1), psychiatric interviews at Time 1 and 3-month follow-up (Time 2), and self-report measures on daily functioning at 6-month follow-up (Time 3)...
January 9, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28052777/from-neurological-soft-signs-to-functional-outcome-in-young-individuals-in-treatment-with-secondary-services-for-non-psychotic-disorders-a-path-analysis
#2
A Minichino, M Francesconi, R E Carrión, R Delle Chiaie, A Bevilacqua, M Parisi, S Rullo, F S Bersani, M Biondi, K Cadenhead
BACKGROUND: Functional decline among patients with mental illness is not unique to individuals with psychotic disorders. Despite this, research on early predictors of functional outcome mainly focused on individuals thought to have an 'at risk mental state' (ARMS) for psychosis. There is evidence suggesting that certain early vulnerability markers, such as neurological soft signs (NSS), may explain variability in functional outcomes independent of the level of psychosis risk and the traditional diagnostic classification...
January 5, 2017: Psychological Medicine
https://www.readbyqxmd.com/read/28041918/prediction-of-functional-outcome-in-young-patients-with-a-recent-onset-psychiatric-disorder-beyond-the-traditional-diagnostic-classification-system
#3
Amedeo Minichino, Marta Francesconi, Ricardo E Carrión, Arturo Bevilacqua, Maurizio Parisi, Santo Rullo, Agata Ando', Massimo Biondi, Roberto Delle Chiaie, Kristin Cadenhead
A critical research goal is to identify modifiable risk factors leading to functional disabilities in young psychiatric patients. The authors developed a multidimensional trans-diagnostic predictive model of functional outcome in patients with the recent-onset of a psychiatric illness. Baseline clinical, psychosis-risk status, cognitive, neurological-soft-signs measures, and dopamine-related-gene polymorphisms (DRD1-rs4532, COMT-rs165599, and DRD4-rs1800955) were collected in 138 young non-psychotic outpatients...
December 29, 2016: Schizophrenia Research
https://www.readbyqxmd.com/read/27992839/psychosis-prediction-in-secondary-mental-health-services-a-broad-comprehensive-approach-to-the-at-risk-mental-state-syndrome
#4
M Francesconi, A Minichino, R E Carrión, R Delle Chiaie, A Bevilacqua, M Parisi, S Rullo, F Saverio Bersani, M Biondi, K Cadenhead
BACKGROUND: Accuracy of risk algorithms for psychosis prediction in "at risk mental state" (ARMS) samples may differ according to the recruitment setting. Standardized criteria used to detect ARMS individuals may lack specificity if the recruitment setting is a secondary mental health service. The authors tested a modified strategy to predict psychosis conversion in this setting by using a systematic selection of trait-markers of the psychosis prodrome in a sample with a heterogeneous ARMS status...
December 16, 2016: European Psychiatry: the Journal of the Association of European Psychiatrists
https://www.readbyqxmd.com/read/27893647/cervical-spine-mri-in-patients-with-negative-ct-a-prospective-multicenter-study-of-the-research-consortium-of-new-england-centers-for-trauma-reconect
#5
Adrian A Maung, Dirk C Johnson, Kimberly Barre, Thomas Peponis, Tomaz Mesar, George C Velmahos, Daniel McGrail, George Kasotakis, Ronald I Gross, Michael S Rosenblatt, Kristen C Sihler, Robert J Winchell, Walter Cholewczynski, Kathryn L Butler, Stephen R Odom, Kimberly A Davis
BACKGROUND: Although cervical spine CT (CSCT) accurately detects bony injuries, it may not identify all soft tissue injuries. Although some clinicians rely exclusively on a negative CT to remove spine precautions in unevaluable patients or patients with cervicalgia, others use MRI for that purpose. The objective of this study was to determine the rates of abnormal MRI after a negative CSCT. METHODS: Blunt trauma patients who either were unevaluable or had persistent midline cervicalgia and underwent an MRI of the C-spine after a negative CSCT were enrolled prospectively in eight Level I and II New England trauma centers...
February 2017: Journal of Trauma and Acute Care Surgery
https://www.readbyqxmd.com/read/27863935/association-of-sflt-1-and-worsening-psychopathology-in-relatives-at-high-risk-for-psychosis-a-longitudinal-study
#6
Paulo L Lizano, Jeffrey K Yao, Neeraj Tandon, Suraj Sarvode Mothi, Debra M Montrose, Matcheri S Keshavan
BACKGROUND: Angiogenic dysfunction and abnormalities in psychopathology and brain structure have been reported in schizophrenia, but their relationships are mostly unknown. We recently demonstrated that sFlt-1, anti-angiogenic factor, was significantly elevated in patients at familial high-risk for psychosis (FHR). We hypothesized that elevated sFlt-1 correlates with baseline and longitudinal changes in psychopathology, cognition, and brain structure. METHODS: Plasma sFlt-1 in FHR (n=35) and HC (n=39) was obtained at baseline...
November 15, 2016: Schizophrenia Research
https://www.readbyqxmd.com/read/27833222/a-study-of-soft-neurological-signs-and-its-correlates-in-drug-naive-patients-with-first-episode-psychosis
#7
Vanishree Gunasekaran, V Mathan Kumar Venkatesh, T V Asokan
BACKGROUND: Soft neurological signs are minor, non localizing, objective abnormalities, thought to reflect damage in cortical and sub-cortical connections or connections within different cortical regions. Regional structural grey matter anomalies have already been observed and correlated with the presence of cognitive deficits and presence of soft neurological signs in schizophrenic patients. MATERIALS AND METHODS: Drug naive patients presenting with first episode of psychosis (FEP)were clinically evaluated for soft neurological signs using the Cambridge Neurological Inventory...
September 2016: Indian Journal of Psychological Medicine
https://www.readbyqxmd.com/read/27805731/cranioplasty-using-titanium-mesh-after-skull-tumor-resection-in-five-dogs
#8
Desiree D Rosselli, Simon R Platt, Courtenay Freeman, Jeremy O'Neill, Marc Kent, Shannon P Holmes
OBJECTIVE: To describe the clinical details, surgery, postoperative imaging, and short to mid-term outcome after cranioplasty with titanium mesh in dogs with large skull tumors. STUDY DESIGN: Case series. ANIMALS: Client-owned dogs with skull tumors (n=5). METHODS: All tumors were removed via craniectomy and a sheet of titanium mesh was contoured to reconstruct the calvarial defect and sutured to surrounding musculature...
November 2, 2016: Veterinary Surgery: VS
https://www.readbyqxmd.com/read/27801772/cranial-nerve-vi-palsy-as-the-main-clinical-manifestation-of-neurosarcoidosis
#9
Zaid A Al-Qudah, Hussam A Yacoub, Nizar Souayah
INTRODUCTION: Sarcoidosis is a chronic, systemic, inflammatory disorder that is characterized by the formation of noncaseating granulomas. Patients may present with cranial nerve palsy, paresthesia, paresis, pyramidal signs, progressive cognitive decline, urinary retention, seizures, or hypothalamic-pituitary syndrome. Although the diagnosis of neurosarcoidosis can be challenging, neurological manifestations of sarcoidosis occur more frequently than previously described. CASE REPORT: A 23-year-old African American man presented to our emergency department with diplopia, which was worsened on left horizontal gaze...
November 2016: Neurologist
https://www.readbyqxmd.com/read/27776367/transoral-atlantoaxial-release-and-posterior-reduction-by-occipitocervical-plate-fixation-for-the-treatment-of-basilar-invagination-with-irreducible-atlantoaxial-dislocation
#10
Qingde Wang, Kezheng Mao, Chunli Wang, Wei Mei
Background Prior studies have mainly assessed transoral odontoidectomy for basilar invagination with irreducible atlantoaxial dislocation. However, studies evaluating transoral release and posterior reduction with occipitocervical fixation in this setting are scarce. Methods From 2008 to 2013, 11 patients (6 men and 5 women; 23-67 years of age) with basilar invagination and irreducible atlantoaxial dislocation underwent surgery. They presented signs and symptoms of myelopathy or significant spinal cord injury, and were treated by transoral soft tissue release without odontoidectomy, under skull traction with heavy weight and by posterior reduction with occipitocervical plate fixation...
October 24, 2016: Journal of Neurological Surgery. Part A, Central European Neurosurgery
https://www.readbyqxmd.com/read/27772538/proposing-the-short-neurological-evaluation-scale
#11
Akin Ojagbemi, Robin Emsley, Oye Gureje
OBJECTIVES: The time required in completing the 26 items of neurological examinations in the standard Neurological Evaluation Scale (NES) may limit its utility in pragmatic clinical situations. We propose the Short Neurological Evaluation Scale (S-NES) for use in busy clinical settings, and in research. METHODS: Using confirmatory factor analyses, we identified 12 items of neurological examination showing significant overlap with previously reported theoretical and empirical categories of neurological soft signs (NSS) in schizophrenia...
October 24, 2016: Acta Neuropsychiatrica
https://www.readbyqxmd.com/read/27731516/transnasal-endoscopically-guided-skull-based-surgery-by-pharyngotomy-for-mass-removal-from-the-sphenopalatine-sinus-in-a-horse
#12
Rolfe M Radcliffe, Yasmine Messiaen, Nita L Irby, Thomas J Divers, Curtis W Dewey, Katharyn J Mitchell, Lauren V Schnabel, Abraham J Bezuidenhout, Peter V Scrivani, Norm G Ducharme
OBJECTIVE: To report a transnasal, endoscopically guided ventral surgical approach for accessing the cranial and caudal segments of the sphenopalatine sinus for mass removal in a horse. STUDY DESIGN: Case report. ANIMAL: Adult horse with acute onset blindness referable to a soft tissue mass within the sphenopalatine sinus. CLINICAL REPORT: A 7-year-old Warmblood gelding presented with a history of running into a fence and falling...
October 12, 2016: Veterinary Surgery: VS
https://www.readbyqxmd.com/read/27690748/neurological-soft-signs-are-associated-with-attentional-dysfunction-in-children-with-attention-deficit-hyperactivity-disorder
#13
Mariabernarda Pitzianti, Elisa D'Agati, Livia Casarelli, Marco Pontis, Ivo Kaunzinger, Klaus W Lange, Oliver Tucha, Paolo Curatolo, Augusto Pasini
INTRODUCTION: Inattention is one of the core symptoms of Attention Deficit Hyperactivity Disorder (ADHD). Most of patients with ADHD show motor impairment, consisting in the persistence of neurological soft signs (NSS). Our aim was to evaluate attentional and motor functioning in an ADHD sample and healthy children (HC) and possible link between attentional dysfunction and motor impairment in ADHD. METHOD: Twenty-seven drug-naive patients with ADHD and 23 HC were tested with a test battery, measuring different aspects of attention...
November 2016: Cognitive Neuropsychiatry
https://www.readbyqxmd.com/read/27673502/cognitive-control-deficit-in-patients-with-first-episode-schizophrenia-is-associated-with-complex-deviations-of%C3%A2-early-brain-development
#14
Olivier Gay, Marion Plaze, Catherine Oppenheim, Raphael Gaillard, Jean-Pierre Olié, Marie-Odile Krebs, Arnaud Cachia
BACKGROUND: Several clinical and radiological markers of early neurodevelopmental deviations have been independently associated with cognitive impairment in patients with schizophrenia. The aim of our study was to test the cumulative and/or interactive effects of these early neurodevelopmental factors on cognitive control (CC) deficit, a core feature of schizophrenia. METHODS: We recruited patients with first-episode schizophrenia-spectrum disorders, who underwent structural MRI...
September 23, 2016: Journal of Psychiatry & Neuroscience: JPN
https://www.readbyqxmd.com/read/27672371/the-semiology-of-motor-disorders-in-autism-spectrum-disorders-as-highlighted-from-a-standardized-neuro-psychomotor-assessment
#15
Aude Paquet, Bertrand Olliac, Manuel-Pierre Bouvard, Bernard Golse, Laurence Vaivre-Douret
BACKGROUND: Altered motor performance has been described in Autism Spectrum Disorders (ASD) with disturbances in walking; posture, coordination, or arm movements, but some individuals with ASD show no impairment of motor skills. The neuro-developmental processes that underpin the performance of neuro-psychomotor functions have not been widely explored, nor is it clear whether there are neuro-psychomotor functions specifically affected in ASD. Our objective was to focus on the semiology of motor disorders among children with ASD using a neuro-developmental assessment tool...
2016: Frontiers in Psychology
https://www.readbyqxmd.com/read/27644917/-left-temporal-arachnoid-cyst-and-specific-learning-disorders-associated-with-pervasive-developmental-disorders-not-otherwise-specified-pdd-nos-contributions-of-an-integrative-neuropsychomotor-neuropsychological-psychopathological-and-neurosurgical-approach
#16
L Vaivre-Douret, A Boschi, M L Cuny, C Clouard, A Mosser, B Golse, A Philippe, M Bourgeois, N Boddaert, S Puget
: Left temporal arachnoid cyst and specific learning disorders associated with pervasive developmental disorders - not otherwise specified (PDD-NOS): contributions of an integrative neuro-psychomotor, neuropsychological, psychopathological and neurosurgical approach about a case report in a child (François). With DSM-IV and DSM-IV-TR, the terminology of pervasive developmental disorders (PDD) covers two main categories of infantile disorders: disorders of "strictly" autistic nature and pervasive developmental disorders - not otherwise specified (PDD-NOS)...
December 2016: L'Encéphale
https://www.readbyqxmd.com/read/27639418/saccadic-eye-movements-as-markers-of-schizophrenia-spectrum-exploration-in-at-risk-mental-states
#17
Simona Caldani, Maria Pia Bucci, Jean-Charles Lamy, Magali Seassau, Narjes Bendjemaa, Rémi Gadel, Raphael Gaillard, Marie-Odile Krebs, Isabelle Amado
Schizophrenia is a neurodevelopmental disease with cognitive and motor impairments. Motor dysfunctions, such as eye movements or Neurological Soft Signs (NSS), are proposed as endophenotypic markers. Antisaccade (AS) and memory-guided saccades (MGS), two markers of inhibitory control mechanism, are altered in both patients with schizophrenia and their relatives, although these tools may have different sensitivities. Recently, emphasis has been put on identifying markers predictive of psychosis transition in subjects with ultra-high-risk psychosis in order to develop targeted prevention...
September 14, 2016: Schizophrenia Research
https://www.readbyqxmd.com/read/27603197/soft-tissue-injury-severity-is-associated-with-neurovascular-injury-in-pediatric-supracondylar-humerus-fractures
#18
Christine A Ho, David A Podeszwa, Anthony I Riccio, Robert L Wimberly, Brandon A Ramo
BACKGROUND: Neurovascular injury in pediatric supracondylar fractures (SCHFx) has been associated with fracture classification but not with soft tissue injury. The purpose of this study is to correlate clinical soft tissue damage to neurovascular injuries in SCHFx. METHODS: This is an institutional review board approved prospective study from January 2010 through December 2013 of 748 operatively treated pediatric SCHFx. Prospective data were gathered both preoperatively and intraoperatively regarding detailed neurovascular examination as well as soft tissue status, with qualitative descriptives for swelling (mild/moderate/severe), ecchymosis, abrasions, skin tenting, and skin puckering...
September 3, 2016: Journal of Pediatric Orthopedics
https://www.readbyqxmd.com/read/27570338/soft-neurological-signs-and-cognitive-function-in-obsessive-compulsive-disorder-patients
#19
Chetali Vijay Dhuri, Shubhangi R Parkar
OBJECTIVE: Modern research on obsessive-compulsive disorder (OCD) indicates that the primary cause of OCD, which was earlier explained only on basis of psychoanalytical theories, is biological. Our study attempts to investigate the neurobiological signs in form of soft neurological signs and cognitive function in OCD. METHODS: A cross sectional study was conducted at psychiatric facility of Seth G.S. Medical College and KEM Hospital. MATERIALS AND METHOD: 50 OCD patients and age- and education-matched controls were selected for the study...
July 2016: Indian Journal of Psychological Medicine
https://www.readbyqxmd.com/read/27548835/dopamine-dysfunction-in-22q11-deletion-syndrome-possible-cause-of-motor-symptoms
#20
Livia Casarelli, Maurizio Minnei, Mariabernarda Pitzianti, Marco Armando, Maria Pontillo, Stefano Vicari, Augusto Pasini
22q11 Deletion syndrome (22q11DS) is a neurogenetic disorder, resulting from a hemizygous microdeletion on the long arm of chromosome 22. In 22q11DS, the phenotypic expression is highly variable. Approximately one-third of all individuals with 22q11DS develop schizophrenia-like psychotic disorder. Among the genes in the deleted region, catechol-O-methyltransferase (COMT) has a particular relevance for psychiatric disorders: lower COMT enzymatic activity decreases the clearance of dopamine (DA), yielding higher levels of catecholamines in the central nervous system...
October 2016: Psychiatric Genetics
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