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https://www.readbyqxmd.com/read/29165861/engineered-biomolecular-recognition-of-rdx-using-a-thermostable-alcohol-dehydrogenase-as-a-protein-scaffold
#1
Beyza Bulutoglu, Jennifer Haghpanah, Elliot Campbell, Scott A Banta
There are many biotechnology applications that would benefit from simple, stable proteins with engineered biomolecular recognition. Here we explored the hypothesis that a thermostable alcohol dehydrogenase (AdhD from P. furisosus) could be engineered to bind a small molecule instead of a cofactor or molecules involved in the catalytic transition state. We chose the explosive molecule 1,3,5-trinitro-1,3,5-triazine (RDX) as a proof-of-concept. Its low solubility in water was exploited for immobilization for biopanning using ribosome display...
November 22, 2017: Chembiochem: a European Journal of Chemical Biology
https://www.readbyqxmd.com/read/29147056/organizing-integrated-health-care-services-to-meet-older-people-s-needs
#2
Islene Araujo de Carvalho, JoAnne Epping-Jordan, Anne Margriet Pot, Edward Kelley, Nuria Toro, Jotheeswaran A Thiyagarajan, John R Beard
In most countries, a fundamental shift in the focus of clinical care for older people is needed. Instead of trying to manage numerous diseases and symptoms in a disjointed fashion, the emphasis should be on interventions that optimize older people's physical and mental capacities over their life course and that enable them to do the things they value. This, in turn, requires a change in the way services are organized: there should be more integration within the health system and between health and social services...
November 1, 2017: Bulletin of the World Health Organization
https://www.readbyqxmd.com/read/29145675/-implementing-the-cross-disciplinary-subject-palliative-care-lecture-s-perspective
#3
Leonie Isermeyer, Benjamin Ilse, Gabriella Marx, Stephanie Seidemann, Jana Jünger, Friedemann Nauck, Bernd Alt-Epping
Introduction In 2009, palliative care was introduced as a mandatory subject in the undergraduate medical curriculum in Germany. Despite all efforts to integrate this subject into the curriculum, research suggests substantial differences and deficits in the quality of education between the medical schools. The aim of this research was to find out promoting as well as impedimental aspects of implementing palliative care in the medical training program. By this, a suitable framework in terms of content and structure for palliative care teaching should be extracted...
November 2017: Deutsche Medizinische Wochenschrift
https://www.readbyqxmd.com/read/29136745/-willingness-and-influencing-factors-of-using-pre-exposure-prophylaxis-among-301-men-have-sex-with-men-in-wuhan-city-2015
#4
P Y Xie, X Wang, P L Liu, X D Tan, W Zhou
Objective: To understand willingness and influencing factors of using pre-exposure prophylaxis (Pr-EP) among men who have sex with men (MSM). Methods: Snow ball sampling was employed to recruit MSM in the social spaces (like bars and bathrooms) with focused activities by MSM and internet (QQ and Wechat) in Wuhan between August and November, 2015. 304 MSM were considered eligible when they were self-identified MSM and has had sex with men in the previous 12 months, over the age of 18 and have full civil liability...
November 6, 2017: Zhonghua Yu Fang Yi Xue za Zhi [Chinese Journal of Preventive Medicine]
https://www.readbyqxmd.com/read/29134301/prostaglandin-e2-receptor-ep1-in-healthy-and-diseased-human-endometrium
#5
Junyan Zhu, Doris Mayr, Christina Kuhn, Sven Mahner, Udo Jeschke, Viktoria von Schönfeldt
Prostaglandin E2 (PGE2) is well described to be associated with both endometrial functions and disorders. The primary aim of this study was to explore the underlying mechanisms that affect the growth and function of endometrial epithelium and stroma by assessing the staining intensity of PGE2 receptors (EP) in healthy endometrium across the menstrual cycle and in pathological endometrium, such as ovarian endometriosis and endometrial cancer. We retrospectively analyzed the EPs staining intensity in human nonpregnant endometrium throughout the menstrual cycle by immunohistochemistry and further focused on EP1 (n = 42)...
November 13, 2017: Histochemistry and Cell Biology
https://www.readbyqxmd.com/read/29130400/a-randomized-controlled-trial-of-cognitive-behavioral-therapy-for-depression-with-integrated-techniques-from-emotion-focused-and-exposure-therapies
#6
Martin Grosse Holtforth, Tobias Krieger, Johannes Zimmermann, David Altenstein-Yamanaka, Nadja Dörig, Laurence Meisch, Adele M Hayes
BACKGROUND: Emotional processing (EP) is hypothesized to be a key mechanism of change in psychotherapy that may enhance its long-term efficacy. To study the effects of fostering EP in psychotherapy for depression, this randomized-controlled clinical trial compares the efficacy and pattern of change of a cognitive-behavioral therapy that integrates emotion-focused techniques within an exposure framework (Exposure-Based Cognitive Therapy for depression; EBCT-R) to a standard cognitive-behavioral therapy (CBT)...
November 12, 2017: Psychotherapy Research: Journal of the Society for Psychotherapy Research
https://www.readbyqxmd.com/read/29119470/failure-to-flow-an-exploration-of-learning-and-teaching-in-busy-multi-patient-environments-using-an-interpretive-description-method
#7
Teresa M Chan, Kenneth Van Dewark, Jonathan Sherbino, Alan Schwartz, Geoff Norman, Matthew Lineberry
INTRODUCTION: As patient volumes continue to increase, more attention must be paid to skills that foster efficiency without sacrificing patient safety. The emergency department is a fertile ground for examining leadership and management skills, especially those that concern prioritization in multi-patient environments. We sought to understand the needs of emergency physicians (EPs) and emergency medicine junior trainees with regards to teaching and learning about how best to handle busy, multi-patient environments...
November 8, 2017: Perspectives on Medical Education
https://www.readbyqxmd.com/read/29078929/blood-product-transfusions-and-reactions
#8
REVIEW
Jessica L Osterman, Sanjay Arora
Blood product transfusions are an essential component of the practice of emergency medicine. From acute traumatic hemorrhage to chronic blood loss necessitating transfusion for symptomatic anemia, familiarity with individual blood products and their indications for transfusion is an essential tool for every emergency physician (EP). Although the focus of this article is primarily on the transfusion of red blood cells, many of the concepts are applicable to the transfusion of all blood products. EPs must be fully familiar with both the individual blood components and the potential reactions and complications of these transfusions...
December 2017: Hematology/oncology Clinics of North America
https://www.readbyqxmd.com/read/29075884/cannabis-use-in-early-psychosis-is-associated-with-reduced-glutamate-levels-in-the-prefrontal-cortex
#9
Silvia Rigucci, Lijing Xin, Paul Klauser, Philipp S Baumann, Luis Alameda, Martine Cleusix, Raoul Jenni, Carina Ferrari, Maurizio Pompili, Rolf Gruetter, Kim Q Do, Philippe Conus
RATIONALE: Recent studies have shown that cannabis may disrupt glutamate (Glu) signaling depressing Glu tone in frequent users. Current evidence have also consistently reported lower Glu-levels in various brain regions, particularly in the medial prefrontal cortex (mPFC) of chronic schizophrenia patients, while findings in early psychosis (EP) are not conclusive. Since cannabis may alter Glu synaptic plasticity and its use is a known risk factor for psychosis, studies focusing on Glu signaling in EP with or without a concomitant cannabis-usage seem crucial...
October 26, 2017: Psychopharmacology
https://www.readbyqxmd.com/read/29039944/3d-printed-microflow-injection-analysis-platform-for-online-magnetic-nanoparticle-sorptive-extraction-of-antimicrobials-in-biological-specimens-as-a-front-end-to-liquid-chromatographic-assays
#10
Han Wang, David J Cocovi-Solberg, Bin Hu, Manuel Miró
In this work, the concept of 3D-printed microflow injection (3D-μFI) embodying a dedicated multifunctional 3D-printed stator onto a rotary microvalve along with a mesofluidic sample preparation platform is proposed for the first time. A transparent 3D-printed stereolithographic mesofluidic chip device accommodating polyaniline (PANI) decorated magnetic nanoparticles (32.5 ± 3.8 mg) is harnessed to in-line sorptive microextraction as a front end to liquid chromatography with peak focusing. As a proof-of-concept application, the 3D-μFI assembly was resorted to matrix cleanup and automatic programmable-flow determination of organic emerging contaminants (4-hydroxybenzoate analogues and triclosan as antimicrobial model analytes) in human saliva and urine samples...
October 31, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/29018058/impact-of-an-inpatient-electronic-prescribing-system-on-prescribing-error-causation-a-qualitative-evaluation-in-an-english-hospital
#11
Seetal Jheeta Puaar, Bryony Dean Franklin
BACKGROUND: Few studies have applied a systems approach to understanding the causes of specific prescribing errors in the context of hospital electronic prescribing (EP). A comprehensive understanding of underlying causes is essential for developing effective interventions to improve prescribing safety. Our objectives were to explore prescribers' perspectives of the causes of errors occurring with EP and to make recommendations to maximise benefits and minimise risks. METHODS: We studied a large hospital using inpatient EP...
October 10, 2017: BMJ Quality & Safety
https://www.readbyqxmd.com/read/28977798/intensified-beclin-1-mediated-by-low-expression-of-mir-30a-5p-promotes-chemoresistance-in-human-small-cell-lung-cancer
#12
Xiang Yang, Fan Bai, Yichen Xu, Yitian Chen, Longbang Chen
BACKGROUND/AIMS: Although small cell lung cancer (SCLC) is sensitive to initial chemotherapy, patients experience tumor recurrence and metastasis, leading to treatment failure. Autophagy as a protective pattern for cell survival in the harsh environment plays an important role in chemoresistance. However, the role of Beclin-1, a key regulator of autophagy in the drug-resistance of SCLC cells is still poorly understood. In the current study, we focused on the effect and regulation of Beclin-1 in chemoresistance of SCLC cells...
2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/28966226/2-ethylpyrazine-induces-vasodilatation-by-releasing-nitric-oxide-in-the-endothelium
#13
Hiroshi Ashigai, Emiko Ikeshima, Kumiko Koizumi, Keiko Nakashima, Mai Mizutani, Hiroaki Yajima
Oxygen transportation and regulation of some physiological processes are facilitated by blood flow. Furthermore, blood flow is regulated by various factors such as nitric oxide (NO) and the autonomic nerve system. In modern life, many people suffer from chilliness (hiesho) because of mental stress and an excessive use air-conditioning systems, which induces vasoconstriction in the peripheral skin. In this study, we focused on pyrazine derivatives, particularly compounds that are used as food flavoring materials, and investigated their effects on vascular function and blood flow...
September 29, 2017: Biological & Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/28963629/life-cycle-assessment-of-a-printed-circuit-board-manufacturing-plant-in-turkey
#14
Elif Ozkan, Nilay Elginoz, Fatos Germirli Babuna
The objective of this study is to investigate the environmental impacts of a printed circuit board (PCB) manufacturing plant through streamlined life cycle assessment approach. As a result, the most effective recommendations on minimizing the environmental impacts for the mentioned sector are revealed and first steps towards establishing a country specific database are taken. The whole PCB production consists of two consecutive stages: namely board fabrication followed by the manufacturing of PCB. Manufacturing of PCB contributes the highest shares to freshwater aquatic ecotoxicity potential (FAETP) and ozone layer depletion potential (ODP)...
September 29, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28911658/identification-of-an-exposure-risk-to-heavy-metals-from-pharmaceutical-grade-rubber-stoppers
#15
Xianghui Li, Pingping Qian
Exposure to low concentrations of heavy metals and metalloids represents a well-documented risk to animal and human health. However, current standards (European Pharmacopeia [EP], United States Pharmacopoeia [USP], International Organization for Standardization [ISO], YBB concerned with rubber closures) only require testing for Zn in pharmaceutical-grade rubber stoppers and then using only pure water as a solvent. We extracted and quantified heavy metals and trace elements from pharmaceutical-grade rubber stoppers under conditions that might occur during the preparation of drugs...
July 2017: Journal of Food and Drug Analysis
https://www.readbyqxmd.com/read/28881905/perforated-esophageal-intervention-focus-perf-study-a-multi-center-examination-of-contemporary-treatment
#16
J T Ali, R D Rice, E A David, J D Spicer, J J Dubose, L Bonavina, S Siboni, T A O'Callaghan, X Luo-Owen, S Harrison, C G Ball, J Bini, G A Vercruysse, D Skarupa, C C Miller Iii, A L Estrera, K G Khalil
The treatment of esophageal perforation (EP) remains a significant clinical challenge. While a number of investigators have previously documented efficient approaches, these were mostly single-center experiences reported prior to the introduction of newer technologies: specifically endoluminal stents. This study was designed to document contemporary practice in the diagnosis and management of EP at multiple institutions around the world and includes early clinical outcomes. A five-year (2009-2013) multicenter retrospective review of management and outcomes for patients with thoracic or abdominal esophageal perforation was conducted...
November 1, 2017: Diseases of the Esophagus: Official Journal of the International Society for Diseases of the Esophagus
https://www.readbyqxmd.com/read/28874931/congratulations-you-re-pregnant-now-about-your-shifts-the-state-of-maternity-leave-attitudes-and-culture-in-em
#17
Casey Z MacVane, Megan L Fix, Tania D Strout, Kate D Zimmerman, Rebecca B Bloch, Christine L Hein
INTRODUCTION: Increasing attention has been focused on parental leave, but little is known about early leave and parental experiences for male and female attending physicians. Our goal was to describe and quantify the parental leave experiences of a nationally representative sample of emergency physicians (EP). METHODS: We conducted a web-based survey, distributed via emergency medicine professional organizations, discussion boards, and listservs, to address study objectives...
August 2017: Western Journal of Emergency Medicine
https://www.readbyqxmd.com/read/28806547/environmental-life-cycle-assessment-of-seafood-production-a-case-study-of-trawler-catches-in-tunisia
#18
Khaled Abdou, Didier Gascuel, Joël Aubin, Mohamed Salah Romdhane, Frida Ben Rais Lasram, François Le Loc'h
The Gulf of Gabes is one of the most productive fishery areas in the southern Mediterranean Sea. It is archetypal of an ecosystem in which the effects of fisheries are most pronounced. Demersal trawling is the main fishing activity in the Gulf of Gabes. Life Cycle Assessment (LCA) was applied to assess the environmental performance landing 1t of seafood with wooden demersal trawlers in the Gulf of Gabes. Impact categories included in the study were abiotic depletion potential (ADP), acidification potential (AP), eutrophication potential (EP), global warming potential (GWP), ozone depletion potential (ODP), photochemical oxidant formation potential (POFP), human toxicity potential (HTP), marine eco-toxicity potential (METP), terrestrial eco-toxicity potential (TETP), land occupation potential (LOP), and total cumulative energy demand (TCED)...
January 1, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/28759964/extracorporeal-perfusion-reduced-to-a-one-way-infusion
#19
Christian D Taeger, Oliver Friedrich, Raymund E Horch, Caroline Drechsler, Annika Weigand, Fabio Hopf, Carol I Geppert, Frank Münch, Torsten Birkholz, Carina Wenzel, Sebastian Geis, Lukas Prantl, Rainer Buchholz, Konstantin Präbst
BACKGROUND: Extracorporeal perfusion (EP) is moving into focus of research in reconstructive and transplantation medicine for the preservation of amputates and free tissue transplants. The idea behind EP is the reduction of ischemia-related cell damage between separation from blood circulation and reanastomosis of the transplant. Most experimental approaches are based on a complex system that moves the perfusate in a circular course. OBJECTIVE AND METHODS: In this study, we aimed to evaluate if a simple perfusion by an infusion bag filled with an electrolyte solution can provide acceptable results in terms of flow stability, oxygen supply and viability conservation for EP of a muscle transplant...
July 25, 2017: Clinical Hemorheology and Microcirculation
https://www.readbyqxmd.com/read/28731881/implementation-of-a-nurse-driven-educational-program-improves-management-of-sorafenib-s-toxicities-in-hepatocellular-carcinoma
#20
Angélique Brunot, Florence Le Roy, Samuel Le Sourd, Amel MʼSadek, Marielle Duval, Laurence Crouzet, Anne Guillygomarcʼh, Eveline Boucher, Brigitte Laguerre, Julien Edeline
BACKGROUND: Sorafenib is the standard treatment of advanced hepatocellular carcinoma. Because of its unique toxicities, improving patients' tolerance merits close follow-up. Nurses can play a crucial role by leading a patient educational program (EP). OBJECTIVES: The aim of this study was to assess whether adding EP to usual care (UC) improves patient's care. METHODS: Since 2011, oncologists referred patients treated by sorafenib to the EP led by clinical nurses...
July 20, 2017: Cancer Nursing
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