keyword
https://read.qxmd.com/read/38533718/patient-genetic-heterogeneities-acting-as-indicators-of-post-operative-pain-and-opioid-requirement-in-orthopedic-surgery-a-systematic-review
#1
JOURNAL ARTICLE
Ahmad Hasan, Adam Pearl, Mohammad Daher, Khaled J Saleh
INTRODUCTION: Orthopedic surgical procedures are expected to increase annually, making it imperative to understand the correlations between patient genetic makeup and post-operative pain levels. METHODS: We performed a systematic literature review using PubMed and Cochrane databases in accordance with Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. A total of 299 articles were initially selected, 20 articles remained after title and abstract review, and nine articles were selected for inclusion upon full text review...
2024: Journal of Opioid Management
https://read.qxmd.com/read/38524188/prolonged-detection-of-urine-norfentanyl-in-individuals-enrolled-in-a-medication-for-opioid-use-disorder-in-pregnancy-and-postpartum-program-a-case-series
#2
JOURNAL ARTICLE
Miranda K Kiefer, Jamie Cowen, Katherine A Hinely, Kara M Rood
BACKGROUND: Although urine drug testing can have vast legal and social ramifications, its interpretation during pregnancy and after birth remains not well understood. Fentanyl metabolism is altered by an individual's genetics, history of opioid use, and liver function. However, little is known about the clearance of fentanyl or its primary metabolite, norfentanyl, in the peripartum period. OBJECTIVE: We sought to identify and describe cases of delayed urine norfentanyl clearance in the pregnancy and postpartum period within our institution...
May 2024: AJOG global reports
https://read.qxmd.com/read/38503843/preconception-opioids-interact-with-mouse-strain-to-alter-morphine-withdrawal-in-the-next-generation
#3
JOURNAL ARTICLE
Anika Toorie, Claire Davidson Hall, Fair M Vassoler, Gary Peltz, Elizabeth M Byrnes
RATIONALE: Transgenerational effects of preconception morphine exposure in female rats have been reported which suggest that epigenetic modifications triggered by female opioid exposure, even when that exposure ends several weeks prior to pregnancy, has significant ramifications for their future offspring. OBJECTIVE: The current study compares two mouse strains with well-established genetic variation in their response to mu opioid receptor agonists, C57BL/6J (BL6) and 129S1/svlmJ (129) to determine whether genetic background modifies the impact of preconception opioid exposure...
March 19, 2024: Psychopharmacology
https://read.qxmd.com/read/38496451/opioid-receptor-expressing-neurons-of-the-central-amygdala-gate-behavioral-effects-of-ketamine-in-mice
#4
Matthew B Pomrenze, Sam Vaillancourt, Pierre Llorach, Daniel Ryskamp Rijsketic, Austen B Casey, Nicholas Gregory, Juliana S Salgado, Robert C Malenka, Boris D Heifets
Ketamine has anesthetic, analgesic, and antidepressant properties which may involve multiple neuromodulatory systems. In humans, the opioid receptor (OR) antagonist naltrexone blocks the antidepressant effect of ketamine. It is unclear whether naltrexone blocks a direct effect of ketamine at ORs, or whether normal functioning of the OR system is required to realize the full antidepressant effects of treatment. In mice, the effect of ketamine on locomotion, but not analgesia or the forced swim test, was sensitive to naltrexone and was therefore used as a behavioral readout to localize the effect of naltrexone in the brain...
March 6, 2024: bioRxiv
https://read.qxmd.com/read/38484627/8-shogaol-derived-from-dietary-ginger-alleviated-acute-and-inflammatory-pain-by-targeting-trpv1
#5
JOURNAL ARTICLE
Xiao-Lan Cheng, Yong-Lan Ruan, Jing-Ya Dai, Hai-Zhen Fan, Jin-Ying Ling, Jiao Chen, Wu-Guang Lu, Xue-Jiao Gao, Peng Cao
Ginger, a well-known spice plant, has been used widely in medicinal preparations for pain relief. However, little is known about its analgesic components and the underlying mechanism. Here, we ascertained, the efficacy of ginger ingredient 8-Shogaol (8S), on inflammatory pain and tolerance induced by morphine, and probed the role of TRPV1 in its analgesic action using genetic and electrophysiology approaches. Results showed that 8S effectively reduced nociceptive behaviors of mice elicited by chemical stimuli, noxious heat as well as inflammation, and antagonized morphine analgesic tolerance independent on opioid receptor function...
February 29, 2024: Phytomedicine
https://read.qxmd.com/read/38477889/adolescent-psychedelic-use-and-psychotic-or-manic-symptoms
#6
JOURNAL ARTICLE
Otto Simonsson, Miriam A Mosing, Walter Osika, Fredrik Ullén, Henrik Larsson, Yi Lu, Laura W Wesseldijk
IMPORTANCE: While psychedelic-assisted therapy has shown promise in the treatment of certain psychiatric disorders, little is known about the potential risk of psychotic or manic symptoms following naturalistic psychedelic use, especially among adolescents. OBJECTIVE: To investigate associations between naturalistic psychedelic use and self-reported psychotic or manic symptoms in adolescents using a genetically informative design. DESIGN, SETTING, AND PARTICIPANTS: This study included a large sample of adolescent twins (assessed at age 15, 18, and 24 years) born between July 1992 and December 2005 from the Swedish Twin Registry and cross-sectionally evaluated the associations between past psychedelic use and psychotic or manic symptoms at age 15 years...
March 13, 2024: JAMA Psychiatry
https://read.qxmd.com/read/38474311/oprm1-gene-polymorphism-in-women-with-alcohol-use-disorder
#7
JOURNAL ARTICLE
Agnieszka Boroń, Aleksandra Suchanecka, Krzysztof Chmielowiec, Małgorzata Śmiarowska, Jolanta Chmielowiec, Aleksandra Strońska-Pluta, Remigiusz Recław, Anna Grzywacz
The main aims of the present study were to explore the relationship of the OPRM1 gene rs1074287 polymorphism in alcohol-dependent women with their personality traits and to try to find out whether any specific features may influence alcohol cravings and be a prognostic for alcohol dependency and treatment in AUD women. Our study found a notable correlation between openness and the interaction of the ORIM1 gene and AUD. The alcohol use disorder subjects with genotype AG showed a higher level of openness compared to the control group with genotypes AG ( p = 0...
March 6, 2024: International Journal of Molecular Sciences
https://read.qxmd.com/read/38465047/the-role-of-epigenetics-and-contributing-impact-of-stress-multigenerational-and-developmental-factors-in-opiate-addiction
#8
REVIEW
Jason Do
Drug addiction is characterized by maladaptive neural plasticity, particularly in vulnerable individuals exposed to drugs of abuse. Epigenetic factors include environmental influences, events during development, and stress adaptations, which seem to play an important role in the neuropathogenesis of drug addiction. This critical review hypothesizes that epigenetic modulation increases an individual's susceptibility to opiate addiction in three key areas of epigenetic study: developmental, stress-related, and transgenerational effects...
February 2024: Curēus
https://read.qxmd.com/read/38457024/effect-of-maoa-rs1465108-polymorphism-on-susceptibility-to-substance-alcohol-use-disorder-a-novel-pcr-rflp-assay-for-the-detection-of-maoa-rs1465108
#9
JOURNAL ARTICLE
Dilek Kaya-Akyüzlü, Selin Özkan-Kotiloğlu, Sariye Aybüke Yıldırım, Mustafa Danışman, Mukaddes Asena Yıldırım, İnci Özgür-İlhan
BACKGROUND: The health and social consequences of substance/alcohol use disorders are harmful. Most of the individuals cannot stop using them due to more likely their genetic background. The current study aimed both to develop a novel PCR-RFLP method for genotyping of MAOA rs1465108 and to analyze the effect of MAOA rs1465108 on the risk of alcohol (AUD), opioid (OUD) or methamphetamine (MUD) use disorders and on the depressive and anxiety symptoms in a Turkish population. METHODS AND RESULTS: A total of 353 individual with AUD (n = 154), OUD (n = 160) or MUD (n = 39) and 109 healthy subjects were included...
March 8, 2024: Molecular Biology Reports
https://read.qxmd.com/read/38438105/structural-instability-and-linear-allocation-control-in-generalized-models-of-substance-use-disorder
#10
JOURNAL ARTICLE
Leigh B Pearcy, Suzanne Lenhart, W Christopher Strickland
Substance use disorder (SUD) is a complex disease involving nontrivial biological, psychological, environmental, and social factors. While many mathematical studies have proposed compartmental models for SUD, almost all of these exclusively model new cases as the result of an infectious process, neglecting any SUD that was primarily developed in social isolation. While these decisions were likely made to facilitate mathematical analysis, isolated SUD development is critical for the most common substances of abuse today, including opioid use disorder developed through prescription use and alcoholism developed primarily due to genetic factors or stress, depression, and other psychological factors...
March 2, 2024: Mathematical Biosciences
https://read.qxmd.com/read/38436758/genetic-mouse-models-in-opioid-research-current-status-and-future-directions
#11
JOURNAL ARTICLE
Monserrat Avila-Zozaya, Venetia Zachariou
Synthetic and semi-synthetic opioids are prescribed for the management of severe pain conditions, but their long-term use is often leading to physical dependence and addiction disorders. Understanding the complex neurobiology of the opioid system in preclinical models will be essential for the development of safe and efficacious analgesics. With rising numbers of synthetic opioid users and overdose cases, a better understanding of the neuroanatomical and cellular pathways associated with physical dependence and addiction is expected to guide treatment approaches for opioid use disorders...
March 4, 2024: Journal of Neural Transmission
https://read.qxmd.com/read/38429522/a-multi-ancestry-genetic-study-of-pain-intensity-in-598-339-veterans
#12
JOURNAL ARTICLE
Sylvanus Toikumo, Rachel Vickers-Smith, Zeal Jinwala, Heng Xu, Divya Saini, Emily E Hartwell, Mirko Pavicic, Kyle A Sullivan, Ke Xu, Daniel A Jacobson, Joel Gelernter, Christopher T Rentsch, Eli Stahl, Martin Cheatle, Hang Zhou, Stephen G Waxman, Amy C Justice, Rachel L Kember, Henry R Kranzler
Chronic pain is a common problem, with more than one-fifth of adult Americans reporting pain daily or on most days. It adversely affects the quality of life and imposes substantial personal and economic costs. Efforts to treat chronic pain using opioids had a central role in precipitating the opioid crisis. Despite an estimated heritability of 25-50%, the genetic architecture of chronic pain is not well-characterized, in part because studies have largely been limited to samples of European ancestry. To help address this knowledge gap, we conducted a cross-ancestry meta-analysis of pain intensity in 598,339 participants in the Million Veteran Program, which identified 126 independent genetic loci, 69 of which are new...
March 1, 2024: Nature Medicine
https://read.qxmd.com/read/38409642/mechanism-of-efferocytosis-in-determining-ischaemic-stroke-resolution-diving-into-microglia-macrophage-functions-and-therapeutic-modality
#13
REVIEW
Xiao-Di Xie, Shan-Shan Dong, Ru-Juan Liu, Liu-Liu Shi, Ting Zhu
After ischaemic cerebral vascular injury, efferocytosis-a process known as the efficient clearance of apoptotic cells (ACs) by various phagocytes in both physiological and pathological states-is crucial for maintaining central nervous system (CNS) homeostasis and regaining prognosis. The mechanisms of efferocytosis in ischaemic stroke and its influence on preventing inflammation progression from secondary injury were still not fully understood, despite the fact that the fundamental process of efferocytosis has been described in a series of phases, including AC recognition, phagocyte engulfment, and subsequent degradation...
February 27, 2024: Molecular Neurobiology
https://read.qxmd.com/read/38406895/mouse-and-rat-anesthesia-and-analgesia
#14
JOURNAL ARTICLE
Sang Su Oh, Heather L Narver
Anesthesia and analgesia play pivotal roles in ethically and humanely using animal models in research, especially concerning mice and rats. These rodent species, extensively utilized in scientific investigations due to their genetic resemblance to humans, serve as invaluable tools for studying diseases and testing treatments. Proper anesthesia and analgesia not only prioritize animal welfare but also heighten experimental validity by minimizing stress-induced physiological responses. Recent years have seen remarkable advancements in anesthesia for mice and rats...
February 2024: Current protocols
https://read.qxmd.com/read/38403942/effects-of-functional-polymorphisms-of-opioid-receptor-mu-1-and-catechol-o-methyltransferase-on-the-neural-processing-of-pain
#15
JOURNAL ARTICLE
Yongjeon Cheong, Seonkyoung Lee, Hidehiko Okazawa, Hirotaka Kosaka, Minyoung Jung
AIM: Pain is reconstructed by brain activities and its subjectivity comes from an interplay of multiple factors. The current study aims to understand the contribution of genetic factors to the neural processing of pain. Focusing on the single-nucleotide polymorphism (SNP) of opioid receptor mu 1 (OPRM1) A118 G (rs1799971) and catechol-O-methyltransferase (COMT) val158 met (rs4680), we investigated how the two pain genes affect pain processing. METHOD: We integrated a genetic approach with functional neuroimaging...
February 25, 2024: Psychiatry and Clinical Neurosciences
https://read.qxmd.com/read/38395375/the-blockade-of-neuropeptide-ff-receptor-1-and-2-differentially-contributed-to-the-modulating-effects-on-fentanyl-induced-analgesia-and-hyperalgesia-in-mice
#16
JOURNAL ARTICLE
Dan Chen, Mengna Zhang, Qinqin Zhang, Shuyuan Wu, Bowen Yu, Xiaodi Zhang, Xuanran Hu, Shichao Zhang, Zhenyun Yang, Junzhe Kuang, Biao Xu, Quan Fang
Neuropeptide FF (NPFF) plays a critical role in various physiological processes through the activation of neuropeptide FF receptor 1 and 2 (NPFFR1 and NPFFR2). Numerous evidence has indicated that NPFF exhibits opposite opioid-modulating effects on opioid-induced analgesia after supraspinal and spinal administrations, while the detailed role of NPFFR1 and NPFFR2 remains unclear. In this study, we employed pharmacological and genetic inhibition of NPFFR to investigate the modulating roles of central NPFFR1 and NPFFR2 in opioid-induced analgesia and hyperalgesia, using a male mouse model of acute fentanyl-induced analgesia and secondary hyperalgesia...
February 22, 2024: European Journal of Pharmacology
https://read.qxmd.com/read/38395372/acute-stress-increases-striatal-connectivity-with-cortical-regions-enriched-for-%C3%AE-and-%C3%AE%C2%BA-opioid-receptors
#17
JOURNAL ARTICLE
Peter Zhukovsky, Maria Ironside, Jessica M Duda, Amelia D Moser, Kaylee E Null, Maeva Dhaynaut, Marc Normandin, Nicolas J Guehl, Georges El Fakhri, Madeline Alexander, Laura M Holsen, Madhusmita Misra, Rajesh Narendran, Jocelyn Hoye, Evan Morris, Shiba M Esfand, Jill M Goldstein, Diego A Pizzagalli
BACKGROUND: Understanding the neurobiological effects of stress is critical for addressing the etiology of major depressive disorder (MDD). Using a dimensional approach involving individuals with differing degree of MDD risk, we investigated (1) the effects of acute stress on cortico-cortical and subcortical-cortical functional connectivity (FC), and (2) how such effects related to gene expression and receptor maps. METHODS: Across 115 participants (37 controls, 39 remitted MDD, 39 current MDD), we evaluated the effects of stress on FC during the Montreal Imaging Stress Task...
February 21, 2024: Biological Psychiatry
https://read.qxmd.com/read/38380709/the-dopamine-3-receptor-as-a-candidate-biomarker-and-therapeutic-for-opioid-use-disorder
#18
JOURNAL ARTICLE
Matthew L Banks, Jon E Sprague
Here, we present recent studies suggesting that specific DRD3 single nucleotide polymorphisms (SNPs, e.g. rs324029 and rs2654754) might serve as prognostic biomarkers for opioid use disorder (OUD). Additionally, preclinical studies with novel dopamine 3 receptor (D3R) partial agonists and antagonists have been evaluated as candidate OUD therapeutics and have shown a reduced risk of cardiovascular toxicity compared with the original D3R antagonist. From these findings, we argue that DRD3 SNPs could serve as a diagnostic tool for assessing OUD risk and that more research is warranted examining the D3R as a safe and effective therapeutic target for treating OUD...
February 2024: Addiction Biology
https://read.qxmd.com/read/38377462/disseminated-mycobacterial-infection-with-reactive-polyarthritis-poncet-s-disease-during-immune-suppressive-treatment-including-ustekinumab-for-pediatric-crohn-s-disease
#19
JOURNAL ARTICLE
Chiara Minotti, Paola Costenaro, Daniele Donà, Monica Zuliani, Luca Bosa, Alberta Leon, Giorgio Perilongo, Paola Gaio, Giorgia Martini, Mara Cananzi
BACKGROUND: The incidence of pediatric inflammatory bowel disease is increasing. tumor necrosis factor alpha inhibitors medicines improved the prognosis of affected subjects. Nonetheless, a proportion of patients do not respond or lose response to treatment. Newer biologics, like ustekinumab, have been approved for adults. The pediatric off-label use of these drugs is increasing, despite limited safety evidence. We report a case of disseminated mycobacterial infection (MI) presenting with reactive polyarthritis (Poncet's disease, PD) in a girl with Crohn's disease receiving various immunosuppressants, including ustekinumab...
February 20, 2024: Pediatric Infectious Disease Journal
https://read.qxmd.com/read/38371655/heartache-and-heartbreak-an-observational-and-mendelian-randomization-study
#20
JOURNAL ARTICLE
Dihui Cai, Mengming Xia, Xuhui Chen, Kunimasa Yagi, Liang Xu, Bingyu Wang, Yanyi Wang, Yujie Zhou, Jianhui Liu
BACKGROUND: Depression has a significant effect on cardiovascular disease (CVD), but uncertainties persist regarding which modifiable risk factors mediate the causal effects. We aim to determine whether depression is causally linked to CVD and which modifiable risk factors play potential mediating roles. METHODS: We used a two-sample Mendelian randomization (MR) approach and NHANES 2007-2018 data to estimate the effects of depression on various CVD cases and investigated 28 potential mediators of the association between depression and CVD...
2024: Global Heart
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