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Dopamine and sex

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https://www.readbyqxmd.com/read/28522735/d3-receptors-regulate-excitability-in-a-unique-class-of-prefrontal-pyramidal-cell
#1
Rebecca L Clarkson, Alayna T Liptak, Steven M Gee, Vikaas S Sohal, Kevin J Bender
The D3 dopamine receptor, a member of the Gi-coupled D2-family of dopamine receptors, is expressed throughout limbic circuits affected in neuropsychiatric disorders, including prefrontal cortex. These receptors are important for prefrontal executive function, as pharmacological and genetic manipulations that affect prefrontal D3 receptors alter anxiety, social interaction, and reversal learning. And yet, the mechanisms by which D3 receptors regulate prefrontal circuits, and whether D3 receptors regulate specific prefrontal subnetworks, remain unknown...
May 17, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/28489770/degeneration-of-corticofugal-fibers-in-a-patient-with-primary-progressive-freezing-gait-a-case-report
#2
Jeong Pyo Seo, Min Cheol Chang
RATIONALE: To report a patient with primary progressive freezing gait (PPFG) whose degeneration of corticofugal tract (CFT) from the supplementary motor area (SMA) was demonstrated using diffusion tensor tractography (DTT). PATIENT CONCERNS: A 66-year-old woman presented with a solitary symptom of a sudden transient break on walking (i.e., freezing gait), which slowly progressed for 4 years. DIAGNOSES: Imaging evidence using magnetic resonance imaging and F-florinated-N-3-fluoropropyl-2-β-carboxymethoxy-3-β-(4-lodophenyl) nortropane positron emission tomography scanning was unremarkable, and our patient's symptom was not affected by dopamine agonist medication...
May 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28485313/clinical-characteristics-and-current-interventions-in-shock-patients-in-chinese-emergency-departments-a-multicenter-prospective-cohort-study
#3
Shu-Bin Guo, Yun-Xia Chen, Xue-Zhong Yu
BACKGROUND: Shock is a life-threatening condition in emergency departments (EDs) and is associated with a high mortality; however, its clinical characteristics and current interventions in China are seldom reported. This study investigated the clinical characteristics and current interventions of shock patients in Chinese EDs. METHODS: This multicenter prospective cohort study was conducted in the EDs of 33 academic hospitals in 16 Chinese provinces. Adult shock patients were enrolled from December 2013 to April 2014...
May 20, 2017: Chinese Medical Journal
https://www.readbyqxmd.com/read/28482339/sex-differences-in-forebrain-monoaminergic-response-to-song-performance
#4
Susan M Lyons, Keith W Sockman
In many species, successful reproduction is dependent on the ability to adjust social behavior in response to an ever-changing social environment. Because a sexual signal's value and meaning can differ between females and males, responses to those signals should also differ. One way individuals can modulate social behavior is through experience-dependent modulation of the sensory systems that process social signals. Central monoamines (norepinephrine, dopamine, serotonin) modulate neural sensitivity to social stimuli and are key regulators of experience-dependent neuroplasticity in vertebrate sensory systems...
May 9, 2017: Brain, Behavior and Evolution
https://www.readbyqxmd.com/read/28473777/investigating-the-role-of-serotonin-in-methamphetamine-psychosis-unaltered-behavioral-effects-of-chronic-methamphetamine-in-5-ht1a-knockout-mice
#5
Emily J Jaehne, Dzeneta Ameti, Tehani Paiva, Maarten van den Buuse
Methamphetamine (Meth) is a widely abused stimulant drug, but this abuse is associated with an increased risk of developing psychosis. In addition to its well-known action on brain dopamine, Meth also affects serotonergic (5-HT) neurons. The aim of this study was to investigate this role in mice, which lack one of the main serotonin receptors, the 5-HT1A receptor, which has been implicated in both schizophrenia and Meth-induced psychosis. Male and female wild-type or 5-HT1A knockout (KO) mice received daily treatment with increasing doses of methamphetamine from 6 to 9 weeks of age (1-4 mg/kg/day twice a day)...
2017: Frontiers in Psychiatry
https://www.readbyqxmd.com/read/28463726/amitraz-changes-ne-da-and-5-ht-biosynthesis-and-metabolism-mediated-by-alterations-in-estradiol-content-in-cns-of-male-rats
#6
Javier Del Pino, Paula Moyano, Matilde Ruiz, María José Anadón, María Jesús Díaz, José Manuel García, Elena Labajo-González, María Teresa Frejo
Amitraz is a formamidine insecticide/acaricide that alters different neurotransmitters levels, among other neurotoxic effects. Oral amitraz exposure (20, 50 and 80 mg/kg bw, 5 days) has been reported to increase serotonin (5-HT), norepinephrine (NE) and dopamine (DA) content and to decrease their metabolites and turnover rates in the male rat brain, particularly in the striatum, prefrontal cortex, and hippocampus. However, the mechanisms by which these alterations are produced are not completely understood...
August 2017: Chemosphere
https://www.readbyqxmd.com/read/28406384/lack-of-increase-in-sexual-drive-and-function-after-dopaminergic-stimulation-in-women
#7
Tillmann H C Krüger, Lydia Keil, Stefanie Jung, Kai G Kahl, Matthias Wittfoth, Brigitte Leeners, Uwe Hartmann
Human and animal data indicate that the dopaminergic system plays a crucial role in sexual drive and function. Using a double-blind, placebo-controlled crossover design this prototype-study investigated the effect of the D2-dopamine agonist cabergoline on sexual parameters in thirteen healthy women. Cardiovascular and genital parameters were monitored continuously. Sexual drive and function were measured using self-report sexual experience scales. In contrast to previous theories and assumptions we found that cabergoline did not alter objective and subjective sexual parameters in healthy women...
April 13, 2017: Journal of Sex & Marital Therapy
https://www.readbyqxmd.com/read/28384481/cognitive-states-influence-dopamine-driven-aberrant-learning-in-parkinson-s-disease
#8
James F Cavanagh, Andrea A Mueller, Darin R Brown, Jacqueline R Janowich, Jacqueline H Story-Remer, Ashley Wegele, Sarah Pirio Richardson
Individual differences in dopaminergic tone underlie tendencies to learn from reward versus punishment. These effects are well documented in Parkinson's patients, who vacillate between low and high tonic dopaminergic states as a function of medication. Yet very few studies have investigated the influence of higher-level cognitive states known to affect downstream dopaminergic learning in Parkinson's patients. A dopamine-dependent cognitive influence over learning would provide a candidate mechanism for declining cognitive integrity and motivation in Parkinson's patients...
March 20, 2017: Cortex; a Journal Devoted to the Study of the Nervous System and Behavior
https://www.readbyqxmd.com/read/28304294/long-term-cognitive-decline-in-dementia-with-lewy-bodies-in-a-large-multicenter-international-cohort
#9
Milica G Kramberger, Bjørn Auestad, Sara Garcia-Ptacek, Carla Abdelnour, Josep Garre Olmo, Zuzana Walker, Afina W Lemstra, Elisabet Londos, Frederic Blanc, Laura Bonanni, Ian McKeith, Bengt Winblad, Frank Jan de Jong, Flavio Nobili, Elka Stefanova, Maria Petrova, Cristian Falup-Pecurariu, Irena Rektorova, Sevasti Bostantjopoulou, Roberta Biundo, Daniel Weintraub, Dag Aarsland
BACKGROUND/OBJECTIVE: The aim of this study was to describe the rate and clinical predictors of cognitive decline in dementia with Lewy bodies (DLB), and compare the findings with Alzheimer's disease (AD) and Parkinson's disease dementia (PDD) patients. METHODS: Longitudinal scores for the Mini-Mental State Examination (MMSE) in 1,290 patients (835 DLB, 198 PDD, and 257 AD) were available from 18 centers with up to three years longitudinal data. Linear mixed effects analyses with appropriate covariates were used to model MMSE decline over time...
2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/28294190/active-and-passive-sexual-roles-that-arise-in-drosophila-male-male-courtship-are-modulated-by-dopamine-levels-in-ppl2ab-neurons
#10
Shiu-Ling Chen, Yu-Hui Chen, Chuan-Chan Wang, Yhu-Wei Yu, Yu-Chen Tsai, Hsiao-Wen Hsu, Chia-Lin Wu, Pei-Yu Wang, Lien-Cheng Chen, Tsuo-Hung Lan, Tsai-Feng Fu
The neurology of male sexuality has been poorly studied owing to difficulties in studying brain circuitry in humans. Dopamine (DA) is essential for both physiological and behavioural responses, including the regulation of sexuality. Previous studies have revealed that alterations in DA synthesis in dopaminergic neurons can induce male-male courtship behaviour, while increasing DA levels in the protocerebral posteriolateral dopaminergic cluster neuron 2ab (PPL2ab) may enhance the intensity of male courtship sustainment in Drosophila...
March 15, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28289796/-neurobiological-foundations-underlying-normal-and-disturbed-sexuality
#11
T H C Krüger, J Kneer
BACKGROUND: Sexual functions are regulated by hormonal and neurochemical factors as well as neuronal networks. An understanding of these basic principles is necessary for the diagnostics, counselling and treatment of sexual problems. OBJECTIVE: Description of essential mechanisms of sexual function on a neurochemical and neuronal level. MATERIAL AND METHODS: Literature search, selection and discussion of relevant studies. RESULTS: Analogous to the dual control model there are primary inhibitory (e...
March 13, 2017: Der Nervenarzt
https://www.readbyqxmd.com/read/28280461/glutamate-and-opioid-antagonists-modulate-dopamine-levels-evoked-by-innately-attractive-male-chemosignals-in-the-nucleus-accumbens-of-female-rats
#12
María-José Sánchez-Catalán, Alejandro Orrico, Lucía Hipólito, Teodoro Zornoza, Ana Polache, Enrique Lanuza, Fernando Martínez-García, Luis Granero, Carmen Agustín-Pavón
Sexual chemosignals detected by vomeronasal and olfactory systems mediate intersexual attraction in rodents, and act as a natural reinforcer to them. The mesolimbic pathway processes natural rewards, and the nucleus accumbens receives olfactory information via glutamatergic projections from the amygdala. Thus, the aim of this study was to investigate the involvement of the mesolimbic pathway in the attraction toward sexual chemosignals. Our data show that female rats with no previous experience with males or their chemosignals display an innate preference for male-soiled bedding...
2017: Frontiers in Neuroanatomy
https://www.readbyqxmd.com/read/28279596/clinical-manifestations-of-nonmotor-symptoms-in-1021-japanese-parkinson-s-disease-patients-from-35-medical-centers
#13
MULTICENTER STUDY
Tetsuya Maeda, Yasushi Shimo, Shih-Wei Chiu, Takuhiro Yamaguchi, Kenichi Kashihara, Yoshio Tsuboi, Masahiro Nomoto, Nobutaka Hattori, Hirohisa Watanabe, Hidemoto Saiki
INTRODUCTION: We aimed to investigate the prevalence and severity of nonmotor symptoms (NMSs) and to identify factors affecting NMSs and the health-related quality of life of Japanese patients with Parkinson's disease (PD). METHODS: A total of 1021 patients with PD who had one or more NMS and showed wearing-off under anti-parkinsonian treatment were enrolled from 35 medical centers in Japan for this observational study. The primary measurements were the Movement Disorder Society unified Parkinson's disease rating scale (MDS-UPDRS) part I and the Parkinson's Disease Questionnaire (PDQ-8)...
May 2017: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/28278565/a-genetic-marker-of-risk-in-hiv-infected-individuals-with-a-history-of-hazardous-drinking
#14
David H Barker, Nicole R Nugent, Jeanne R Delgado, Valerie S Knopik, Larry K Brown, Michelle A Lally, John E McGeary
Impulsivity and sensation seeking have been linked to hazardous drinking, increased sexual risk behaviors, and lower treatment adherence among persons living with HIV (PLH). The dopamine active transporter1 (DAT1or SLC6A3) gene has been linked to impulsivity and sensation seeking in several populations but has not been investigated among populations of PLH. This study used data from 201 PLH who report a recent history of heavy episodic drinking. Results indicate that DAT1*10R vs DAT1*9R genotype was related to higher propensity for risk taking (standardized difference score (d) = 0...
February 21, 2017: AIDS Care
https://www.readbyqxmd.com/read/28254511/voxel-based-logistic-analysis-of-ppmi-control-and-parkinson-s-disease-datscans
#15
Hemant D Tagare, Christine DeLorenzo, Sudhakar Chelikani, Lawrence Saperstein, Robert K Fulbright
A comprehensive analysis of the Parkinson's Progression Markers Initiative (PPMI) Dopamine Transporter Single Photon Emission Computed Tomography (DaTscan) images is carried out using a voxel-based logistic lasso model. The model reveals that sub-regional voxels in the caudate, the putamen, as well as in the globus pallidus are informative for classifying images into control and PD classes. Further, a new technique called logistic component analysis is developed. This technique reveals that intra-population differences in dopamine transporter concentration and imperfect normalization are significant factors influencing logistic analysis...
February 27, 2017: NeuroImage
https://www.readbyqxmd.com/read/28249785/identifying-the-presence-of-parkinson-s-disease-using-low-frequency-fluctuations-in-bold-signals
#16
Yan Tang, Li Meng, Chang-Min Wan, Zhen-Hua Liu, Wei-Hua Liao, Xin-Xiang Yan, Xiao-Yu Wang, Bei-Sha Tang, Ji-Feng Guo
Parkinson's disease (PD) is a chronic, progressive, and degenerative neurological disorder that is characterized by the degeneration of dopamine neurons in the substantia nigra and the formation of intracellular Lewy inclusion bodies. Resting-state functional magnetic resonance imaging (RS-fMRI) has demonstrated evidence of changes in metabolic patterns in individuals with PD. The purpose of this study was to determine whether the presence of PD could be "predicted" based on resting fluctuations in the blood oxygenation level dependent signal...
April 3, 2017: Neuroscience Letters
https://www.readbyqxmd.com/read/28241982/association-of-the-dopamine-d2-receptor-rs1800497-polymorphism-and-eating-behavior-in-chilean-children
#17
Ana M Obregón, Macarena Valladares, Gary Goldfield
OBJECTIVES: Studies have established a strong genetic component in eating behavior. The TaqI A1 polymorphism (rs1800497) has previously been associated with obesity and eating behavior. Additionally, this polymorphism has been associated with diminished dopamine D2 receptor (DRD2) density, higher body mass, and food reinforcement. The aim of this study was to evaluate the association between the DRD2 rs1800497 polymorphism and eating behavior in Chilean children. METHODS: This was a cross-sectional study in which we selected 258 children (44% girls, 56% boys; ages 8-14 y) with a wide variation in body mass index...
March 2017: Nutrition
https://www.readbyqxmd.com/read/28240292/the-role-of-dorsal-hippocampal-dopamine-d1-type-receptors-in-social-learning-social-interactions-and-food-intake-in-male-and-female-mice
#18
Richard Matta, Angela N Tiessen, Elena Choleris
The neurobiological mechanisms underlying social learning (ie, in which an animal's learning is influenced by another) are slowly being unraveled. Previous work with systemic treatments shows that dopamine (DA) D1-type receptors mediate social learning in the social transmission of food preferences (STFP) in mice. This study examines the involvement of one brain region underlying this effect. The ventral tegmental area has dopaminergic projections to many limbic structures, including the hippocampus-a site important for social learning in the STFP in rodents...
March 29, 2017: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/28195063/generation-of-membrane-bound-catechol-o-methyl-transferase-deficient-mice-with-disctinct-sex-dependent-behavioral-phenotype
#19
A Tammimaki, A Aonurm-Helm, F P Zhang, M Poutanen, G Duran-Torres, A Garcia-Horsman, P T Mannisto
Catechol-O-methyltransferase (COMT) has two isoforms: soluble (S-COMT), which resides in the cytoplasm, and membrane-bound (MB-MT), anchored to intracellular membranes. COMT is involved in the O-methylation of L-DOPA, dopamine and other catechols. The exact role of MB-COMT is still mostly unclear. We wanted to create a novel genetically modified mouse model that specifically lacks MB-COMT activity and to study their behavioral phenotype. MB-COMT knock-in mutant mice were generated by introducing two point mutations in exon 2 of the Comt gene (ATGCTG->GAGCTC disabling the function of the P2 promoter and allowing only the P1-regulated S-COMT transcription...
December 2016: Journal of Physiology and Pharmacology: An Official Journal of the Polish Physiological Society
https://www.readbyqxmd.com/read/28187160/the-effects-of-dopamine-receptor-1-and-2-agonists-and-antagonists-on-sexual-and-aggressive-behaviors-in-male-green-anoles
#20
Alexandra N Smith, David Kabelik
The propensity to exhibit social behaviors during interactions with same-sex and opposite-sex conspecifics is modulated by various neurotransmitters, including dopamine. Dopamine is a conserved neurotransmitter among vertebrates and dopaminergic receptors are also highly conserved among taxa. Activation of D1 and D2 dopamine receptor subtypes has been shown to modulate social behaviors, especially in mammalian and avian studies. However, the specific behavioral functions of these receptors vary across taxa...
2017: PloS One
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