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Dopamine and sex

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https://www.readbyqxmd.com/read/28406384/lack-of-increase-in-sexual-drive-and-function-after-dopaminergic-stimulation-in-women
#1
Tillmann H C Krüger, Lydia Keil, Stefanie Jung, Kai G Kahl, Matthias Wittfoth, Brigitte Leeners, Uwe Hartmann
Human and animal data indicate that the dopaminergic system plays a crucial role in sexual drive and function. Using a double-blind, placebo-controlled crossover design this prototype-study investigated the effect of the D2-dopamine agonist cabergoline on sexual parameters in thirteen healthy women. Cardiovascular and genital parameters were monitored continuously. Sexual drive and function were measured using self-report sexual experience scales. In contrast to previous theories and assumptions we found that cabergoline did not alter objective and subjective sexual parameters in healthy women...
April 13, 2017: Journal of Sex & Marital Therapy
https://www.readbyqxmd.com/read/28384481/cognitive-states-influence-dopamine-driven-aberrant-learning-in-parkinson-s-disease
#2
James F Cavanagh, Andrea A Mueller, Darin R Brown, Jacqueline R Janowich, Jacqueline H Story-Remer, Ashley Wegele, Sarah Pirio Richardson
Individual differences in dopaminergic tone underlie tendencies to learn from reward versus punishment. These effects are well documented in Parkinson's patients, who vacillate between low and high tonic dopaminergic states as a function of medication. Yet very few studies have investigated the influence of higher-level cognitive states known to affect downstream dopaminergic learning in Parkinson's patients. A dopamine-dependent cognitive influence over learning would provide a candidate mechanism for declining cognitive integrity and motivation in Parkinson's patients...
March 20, 2017: Cortex; a Journal Devoted to the Study of the Nervous System and Behavior
https://www.readbyqxmd.com/read/28304294/long-term-cognitive-decline-in-dementia-with-lewy-bodies-in-a-large-multicenter-international-cohort
#3
Milica G Kramberger, Bjørn Auestad, Sara Garcia-Ptacek, Carla Abdelnour, Josep Garre Olmo, Zuzana Walker, Afina W Lemstra, Elisabet Londos, Frederic Blanc, Laura Bonanni, Ian McKeith, Bengt Winblad, Frank Jan de Jong, Flavio Nobili, Elka Stefanova, Maria Petrova, Cristian Falup-Pecurariu, Irena Rektorova, Sevasti Bostantjopoulou, Roberta Biundo, Daniel Weintraub, Dag Aarsland
BACKGROUND/OBJECTIVE: The aim of this study was to describe the rate and clinical predictors of cognitive decline in dementia with Lewy bodies (DLB), and compare the findings with Alzheimer's disease (AD) and Parkinson's disease dementia (PDD) patients. METHODS: Longitudinal scores for the Mini-Mental State Examination (MMSE) in 1,290 patients (835 DLB, 198 PDD, and 257 AD) were available from 18 centers with up to three years longitudinal data. Linear mixed effects analyses with appropriate covariates were used to model MMSE decline over time...
2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/28294190/active-and-passive-sexual-roles-that-arise-in-drosophila-male-male-courtship-are-modulated-by-dopamine-levels-in-ppl2ab-neurons
#4
Shiu-Ling Chen, Yu-Hui Chen, Chuan-Chan Wang, Yhu-Wei Yu, Yu-Chen Tsai, Hsiao-Wen Hsu, Chia-Lin Wu, Pei-Yu Wang, Lien-Cheng Chen, Tsuo-Hung Lan, Tsai-Feng Fu
The neurology of male sexuality has been poorly studied owing to difficulties in studying brain circuitry in humans. Dopamine (DA) is essential for both physiological and behavioural responses, including the regulation of sexuality. Previous studies have revealed that alterations in DA synthesis in dopaminergic neurons can induce male-male courtship behaviour, while increasing DA levels in the protocerebral posteriolateral dopaminergic cluster neuron 2ab (PPL2ab) may enhance the intensity of male courtship sustainment in Drosophila...
March 15, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28289796/-neurobiological-foundations-underlying-normal-and-disturbed-sexuality
#5
T H C Krüger, J Kneer
BACKGROUND: Sexual functions are regulated by hormonal and neurochemical factors as well as neuronal networks. An understanding of these basic principles is necessary for the diagnostics, counselling and treatment of sexual problems. OBJECTIVE: Description of essential mechanisms of sexual function on a neurochemical and neuronal level. MATERIAL AND METHODS: Literature search, selection and discussion of relevant studies. RESULTS: Analogous to the dual control model there are primary inhibitory (e...
March 13, 2017: Der Nervenarzt
https://www.readbyqxmd.com/read/28280461/glutamate-and-opioid-antagonists-modulate-dopamine-levels-evoked-by-innately-attractive-male-chemosignals-in-the-nucleus-accumbens-of-female-rats
#6
María-José Sánchez-Catalán, Alejandro Orrico, Lucía Hipólito, Teodoro Zornoza, Ana Polache, Enrique Lanuza, Fernando Martínez-García, Luis Granero, Carmen Agustín-Pavón
Sexual chemosignals detected by vomeronasal and olfactory systems mediate intersexual attraction in rodents, and act as a natural reinforcer to them. The mesolimbic pathway processes natural rewards, and the nucleus accumbens receives olfactory information via glutamatergic projections from the amygdala. Thus, the aim of this study was to investigate the involvement of the mesolimbic pathway in the attraction toward sexual chemosignals. Our data show that female rats with no previous experience with males or their chemosignals display an innate preference for male-soiled bedding...
2017: Frontiers in Neuroanatomy
https://www.readbyqxmd.com/read/28279596/clinical-manifestations-of-nonmotor-symptoms-in-1021-japanese-parkinson-s-disease-patients-from-35-medical-centers
#7
Tetsuya Maeda, Yasushi Shimo, Shih-Wei Chiu, Takuhiro Yamaguchi, Kenichi Kashihara, Yoshio Tsuboi, Masahiro Nomoto, Nobutaka Hattori, Hirohisa Watanabe, Hidemoto Saiki
INTRODUCTION: We aimed to investigate the prevalence and severity of nonmotor symptoms (NMSs) and to identify factors affecting NMSs and the health-related quality of life of Japanese patients with Parkinson's disease (PD). METHODS: A total of 1021 patients with PD who had one or more NMS and showed wearing-off under anti-parkinsonian treatment were enrolled from 35 medical centers in Japan for this observational study. The primary measurements were the Movement Disorder Society unified Parkinson's disease rating scale (MDS-UPDRS) part I and the Parkinson's Disease Questionnaire (PDQ-8)...
February 21, 2017: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/28278565/a-genetic-marker-of-risk-in-hiv-infected-individuals-with-a-history-of-hazardous-drinking
#8
David H Barker, Nicole R Nugent, Jeanne R Delgado, Valerie S Knopik, Larry K Brown, Michelle A Lally, John E McGeary
Impulsivity and sensation seeking have been linked to hazardous drinking, increased sexual risk behaviors, and lower treatment adherence among persons living with HIV (PLH). The dopamine active transporter1 (DAT1or SLC6A3) gene has been linked to impulsivity and sensation seeking in several populations but has not been investigated among populations of PLH. This study used data from 201 PLH who report a recent history of heavy episodic drinking. Results indicate that DAT1*10R vs DAT1*9R genotype was related to higher propensity for risk taking (standardized difference score (d) = 0...
February 21, 2017: AIDS Care
https://www.readbyqxmd.com/read/28254511/voxel-based-logistic-analysis-of-ppmi-control-and-parkinson-s-disease-datscans
#9
Hemant D Tagare, Christine DeLorenzo, Sudhakar Chelikani, Lawrence Saperstein, Robert K Fulbright
A comprehensive analysis of the Parkinson's Progression Markers Initiative (PPMI) Dopamine Transporter Single Photon Emission Computed Tomography (DaTscan) images is carried out using a voxel-based logistic lasso model. The model reveals that sub-regional voxels in the caudate, the putamen, as well as in the globus pallidus are informative for classifying images into control and PD classes. Further, a new technique called logistic component analysis is developed. This technique reveals that intra-population differences in dopamine transporter concentration and imperfect normalization are significant factors influencing logistic analysis...
February 27, 2017: NeuroImage
https://www.readbyqxmd.com/read/28249785/identifying-the-presence-of-parkinson-s-disease-using-low-frequency-fluctuations-in-bold-signals
#10
Yan Tang, Li Meng, Chang-Min Wan, Zhen-Hua Liu, Wei-Hua Liao, Xin-Xiang Yan, Xiao-Yu Wang, Bei-Sha Tang, Ji-Feng Guo
Parkinson's disease (PD) is a chronic, progressive, and degenerative neurological disorder that is characterized by the degeneration of dopamine neurons in the substantia nigra and the formation of intracellular Lewy inclusion bodies. Resting-state functional magnetic resonance imaging (RS-fMRI) has demonstrated evidence of changes in metabolic patterns in individuals with PD. The purpose of this study was to determine whether the presence of PD could be "predicted" based on resting fluctuations in the blood oxygenation level dependent signal...
April 3, 2017: Neuroscience Letters
https://www.readbyqxmd.com/read/28241982/association-of-the-dopamine-d2-receptor-rs1800497-polymorphism-and-eating-behavior-in-chilean-children
#11
Ana M Obregón, Macarena Valladares, Gary Goldfield
OBJECTIVES: Studies have established a strong genetic component in eating behavior. The TaqI A1 polymorphism (rs1800497) has previously been associated with obesity and eating behavior. Additionally, this polymorphism has been associated with diminished dopamine D2 receptor (DRD2) density, higher body mass, and food reinforcement. The aim of this study was to evaluate the association between the DRD2 rs1800497 polymorphism and eating behavior in Chilean children. METHODS: This was a cross-sectional study in which we selected 258 children (44% girls, 56% boys; ages 8-14 y) with a wide variation in body mass index...
March 2017: Nutrition
https://www.readbyqxmd.com/read/28240292/the-role-of-dorsal-hippocampal-dopamine-d1-type-receptors-in-social-learning-social-interactions-and-food-intake-in-male-and-female-mice
#12
Richard Matta, Angela Nicole Tiessen, Elena Choleris
The neurobiological mechanisms underlying social learning (ie, in which an animals learning is influenced by another) are slowly being unraveled. Previous work with systemic treatments shows that dopamine (DA) D1-type receptors mediate social learning in the social transmission of food preferences (STFP) in mice (Choleris et al, 2011). This study examines the involvement of one brain region underlying this effect. The ventral tegmental area has dopaminergic projections to many limbic structures, including the hippocampus-a site important for social learning in the STFP in rodents...
February 27, 2017: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/28195063/generation-of-membrane-bound-catechol-o-methyl-transferase-deficient-mice-with-disctinct-sex-dependent-behavioral-phenotype
#13
A Tammimaki, A Aonurm-Helm, F P Zhang, M Poutanen, G Duran-Torres, A Garcia-Horsman, P T Mannisto
Catechol-O-methyltransferase (COMT) has two isoforms: soluble (S-COMT), which resides in the cytoplasm, and membrane-bound (MB-MT), anchored to intracellular membranes. COMT is involved in the O-methylation of L-DOPA, dopamine and other catechols. The exact role of MB-COMT is still mostly unclear. We wanted to create a novel genetically modified mouse model that specifically lacks MB-COMT activity and to study their behavioral phenotype. MB-COMT knock-in mutant mice were generated by introducing two point mutations in exon 2 of the Comt gene (ATGCTG->GAGCTC disabling the function of the P2 promoter and allowing only the P1-regulated S-COMT transcription...
December 2016: Journal of Physiology and Pharmacology: An Official Journal of the Polish Physiological Society
https://www.readbyqxmd.com/read/28187160/the-effects-of-dopamine-receptor-1-and-2-agonists-and-antagonists-on-sexual-and-aggressive-behaviors-in-male-green-anoles
#14
Alexandra N Smith, David Kabelik
The propensity to exhibit social behaviors during interactions with same-sex and opposite-sex conspecifics is modulated by various neurotransmitters, including dopamine. Dopamine is a conserved neurotransmitter among vertebrates and dopaminergic receptors are also highly conserved among taxa. Activation of D1 and D2 dopamine receptor subtypes has been shown to modulate social behaviors, especially in mammalian and avian studies. However, the specific behavioral functions of these receptors vary across taxa...
2017: PloS One
https://www.readbyqxmd.com/read/28179811/sex-differences-in-addiction
#15
Jill B Becker
Women exhibit more rapid escalation from casual drug taking to addiction, exhibit a greater withdrawal response with abstinence, and tend to exhibit greater vulnerability than men in terms of treatment outcome. In rodents, short-term estradiol intake in female rats enhances acquisition and escalation of drug taking, motivation for drugs of abuse, and relapse-like behaviors. There is also a sex difference in the dopamine response in the nucleus accumbens. Ovariectomized female rats exhibit a smaller initial dopamine increase after cocaine treatment than castrated males...
December 2016: Dialogues in Clinical Neuroscience
https://www.readbyqxmd.com/read/28112452/disruption-of-dopamine-homeostasis-has-sexually-dimorphic-effects-on-senescence-characteristics-of-drosophila-melanogaster
#16
Andrea Bednářová, Marley E Hanna, Kuntol Rakshit, Janis M O'Donnell, Natraj Krishnan
The neurotransmitter dopamine (DA) is known to be involved in a multitude of physiological processes. We investigated sexually dimorphic effects of disruptions in DA homeostasis and its relationship to senescence using three different Drosophila melanogaster mutants namely Catsup (Catsup(26) ) with elevated DA levels, and pale (ple(2) ), Punch (Pu(Z22) ) with depleted DA levels. In all genotypes including controls, DA levels were significantly lower in old (45-50-day-old) flies compared with young (3-5-day-old) in both sexes...
March 2017: European Journal of Neuroscience
https://www.readbyqxmd.com/read/28090348/changes-in-hba1c-and-circulating-and-adipose-tissue-androgen-levels-in-overweight-obese-women-with-polycystic-ovary-syndrome-in-response-to-electroacupuncture
#17
E Stener-Victorin, M Maliqueo, M Soligo, V Protto, L Manni, E Jerlhag, M Kokosar, A Sazonova, C J Behre, M Lind, C Ohlsson, K Højlund, A Benrick
AIM: Insulin sensitivity is ~40% lower in women with polycystic ovary syndrome (PCOS) than in controls. We tested the hypothesis that 5 weeks of electroacupuncture treatment improves glucose regulation and androgen levels in overweight/obese women with PCOS. MATERIAL AND METHODS: Seventeen women with PCOS, aged 18 to 38 years, with a body mass index (BMI) ≥25 kg/m(2) and diagnosed with PCOS were included in this experimental and feasibility study and subjected to five weeks of electroacupuncture treatments three times/week...
December 2016: Obesity Science & Practice
https://www.readbyqxmd.com/read/28088038/evidence-of-functional-duplicity-of-nestin-expression-in-the-adult-mouse-midbrain
#18
Parisa Farzanehfar, Shi Sheng Lu, Anupa Dey, Dharshani Musiienko, Hamzah Baagil, Malcolm K Horne, Tim D Aumann
Whether or not neurogenesis occurs in the adult substantia nigra pars compacta (SNc) is an important question relevant for developing better treatments for the motor symptoms of Parkinson's disease (PD). Although controversial, it is generally believed that dividing cells here remain undifferentiated or differentiate into glia, not neurons. However, there is a suggestion that Nestin-expressing neural precursor cells (NPCs) in the adult SNc have a propensity to differentiate into neurons, which we sought to confirm in the present study...
January 5, 2017: Stem Cell Research
https://www.readbyqxmd.com/read/28072417/dopaminergic-dynamics-underlying-sex-specific-cocaine-reward
#19
Erin S Calipari, Barbara Juarez, Carole Morel, Deena M Walker, Michael E Cahill, Efrain Ribeiro, Ciorana Roman-Ortiz, Charu Ramakrishnan, Karl Deisseroth, Ming-Hu Han, Eric J Nestler
Although both males and females become addicted to cocaine, females transition to addiction faster and experience greater difficulties remaining abstinent. We demonstrate an oestrous cycle-dependent mechanism controlling increased cocaine reward in females. During oestrus, ventral tegmental area (VTA) dopamine neuron activity is enhanced and drives post translational modifications at the dopamine transporter (DAT) to increase the ability of cocaine to inhibit its function, an effect mediated by estradiol. Female mice conditioned to associate cocaine with contextual cues during oestrus have enhanced mesolimbic responses to these cues in the absence of drug...
January 10, 2017: Nature Communications
https://www.readbyqxmd.com/read/28065748/the-effects-of-early-life-stress-on-dopamine-system-function-in-adolescent-female-rats
#20
Iwona Majcher-Maślanka, Anna Solarz, Krzysztof Wędzony, Agnieszka Chocyk
During adolescence, many neural systems, including the dopamine system, undergo essential remodeling and maturation. It is well known that early-life stress (ELS) increases the risk for many psychopathologies during adolescence and adulthood. It is hypothesized that ELS interferes with the maturation of the dopamine system. There is a sex bias in the prevalence of stress-related mental disorders. Information regarding the effects of ELS on brain functioning in females is very limited. In the current study, maternal separation (MS) procedures were carried out to study the effects of ELS on dopamine system functioning in adolescent female rats...
April 2017: International Journal of Developmental Neuroscience
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