keyword
https://read.qxmd.com/read/37808880/composition-of-ex-vivo-perfusion-solutions-and-kinetics-define-differential-cytokine-chemokine-secretion-in-a-porcine-cardiac-arrest-model-of-lung-preservation
#21
JOURNAL ARTICLE
Lena Radomsky, Achim Koch, Carolin Olbertz, Yongjie Liu, Kerstin Beushausen, Jana Keil, Ursula Rauen, Christine S Falk, Jenny F Kühne, Markus Kamler
BACKGROUND: Ex vivo lung perfusion (EVLP) uses continuous normothermic perfusion to reduce ischemic damage and to improve post-transplant outcomes, specifically for marginal donor lungs after the donation after circulatory death. Despite major efforts, the optimal perfusion protocol and the composition of the perfusate in clinical lung transplantation have not been identified. Our study aims to compare the concentration levels of cytokine/chemokine in different perfusion solutions during EVLP, after 1 and 9 h of cold static preservation (CSP) in a porcine cardiac arrest model, and to correlate inflammatory parameters to oxygenation capacities...
2023: Frontiers in Cardiovascular Medicine
https://read.qxmd.com/read/37790622/analysis-of-cerebral-interleukin-6-and-tumor-necrosis-factor-alpha-patterns-following-different-ventilation-strategies-during-cardiac-arrest-in-pigs
#22
JOURNAL ARTICLE
Miriam Renz, Lea Müller, Manuel Herbst, Julian Riedel, Katja Mohnke, Alexander Ziebart, Robert Ruemmler
Hypoxia-induced neuroinflammation after cardiac arrest has been shown to be mitigated by different ventilation methods. In this prospective randomized animal trial, 35 landrace pigs were randomly divided into four groups: intermittent positive pressure ventilation (IPPV), synchronized ventilation 20 mbar (SV 20 mbar), chest compression synchronized ventilation 40 mbar (CCSV 40 mbar) and a control group (Sham). After inducing ventricular fibrillation, basic life support (BLS) and advanced life support (ALS) were performed, followed by post-resuscitation monitoring...
2023: PeerJ
https://read.qxmd.com/read/37757567/electrical-mechanical-dynamical-coupling-between-electrocardiographic-and-photoplethysmographic-signals-during-cardiopulmonary-resuscitation
#23
JOURNAL ARTICLE
Shuxin Chen, Lijun Jiang, Feng Xu, Jiaojiao Pang, Chang Pan, Yuguo Chen, Jiali Wang, Ke Li
BACKGROUND AND OBJECTIVE: Cardiac arrest (CA) remains a significant cause of death and disability. High-quality cardiopulmonary resuscitation (CPR) can improve the survival rate of CA. A challenging issue is to find physiological indicators for screening and evaluating the cardiovascular function associated with CPR. This study aimed to investigate the electrical-mechanical dynamic coupling between electrocardiographic (ECG) and photoplethysmographic (PPG) signals for indicating cardiovascular function in the progress of CPR...
September 23, 2023: Computer Methods and Programs in Biomedicine
https://read.qxmd.com/read/37716402/effect-of-first-epinephrine-administration-time-on-cerebral-perfusion-pressure-and-cortical-cerebral-blood-flow-in-a-porcine-cardiac-arrest-model
#24
JOURNAL ARTICLE
Dong Hyun Choi, Ki Jeong Hong, Ki Hong Kim, Sang Do Shin, Kyoung Jun Song, Yoonjic Kim, Yoon Ha Joo, Jeong Ho Park, Young Sun Ro, Hyun Jeong Kang
OBJECTIVE: The optimal time for epinephrine administration and its effects on cerebral blood flow (CBF) and microcirculation remain controversial. This study aimed to assess the effect of the first administration of epinephrine on cerebral perfusion pressure (CePP) and cortical CBF in porcine cardiac arrest model. METHODS: After 4 min of untreated ventricular fibrillation, eight of 24 swine were randomly assigned to the early, intermediate, and late groups. In each group, epinephrine was administered intravenously at 5, 10, and 15 min after cardiac arrest induction...
September 14, 2023: Resuscitation
https://read.qxmd.com/read/37694356/protection-of-the-endothelium-and-endothelial-glycocalyx-by-hydrogen-against-ischaemia-reperfusion-injury-in-a-porcine-model-of-cardiac-arrest
#25
JOURNAL ARTICLE
David Astapenko, Radomir Hyspler, Alena Tich, Adela Tomasova, Pavel Navratil, Marek Zrzavecky, Bhavya Byreddy, Petr Sedlacek, Vera Radochova, Roman Skulec, Robert G Hahn, Christian Lehmann, Manu L N G Malbrain, Vladimir Cerny
BACKGROUND: Hydrogen is a potent antioxidant agent that can easily be administered by inhalation. The aim of the study was to evaluate whether hydrogen protects the endothelial glycocalyx layer after successful cardiopulmonary resuscitation (CPR). METHODS: Fourteen anesthetized pigs underwent CPR after induced ventricular fibrillation. During CPR and return of spontaneous circulation, 2% hydrogen gas was administered to seven pigs (hydrogen group) and seven constituted a control group...
September 2, 2023: Clinical Hemorheology and Microcirculation
https://read.qxmd.com/read/37659143/the-effects-of-methylene-blue-during-and-after-cardiac-arrest-in-a-porcine-model-a-randomized-blinded-placebo-controlled-study
#26
JOURNAL ARTICLE
Cecilie Munch Johannsen, Casper Nørholt, Cecilie Baltsen, Mark A Eggertsen, Andreas Magnussen, Lasse Vormfenne, Signe Østergaard Mortensen, Esben Søvsø Szocska Hansen, Lauge Vammen, Lars W Andersen, Asger Granfeldt
PURPOSE: To evaluate the effect of methylene blue administered as a bolus on return of spontaneous circulation (ROSC), lactate levels, vasopressor requirements, and markers of neurological injury in a clinically relevant pig model of cardiac arrest. MATERIALS AND METHODS: 40 anesthetized pigs were subjected to acute myocardial infarction and 7 min of untreated cardiac arrest. Animals were randomized into three groups: one group received saline only (controls), one group received 2 mg/kg methylene blue and saline (MB + saline), and one group received two doses of 2 mg/kg methylene blue (MB + MB)...
August 25, 2023: American Journal of Emergency Medicine
https://read.qxmd.com/read/37656974/machine-perfusion-preservation-with-hemoglobin-based-oxygen-vesicles-alleviate-ultrastructural-damages-in-porcine-liver-donated-after-cardiac-death
#27
JOURNAL ARTICLE
Nur Khatijah Mohd Zin, Hiroki Bochimoto, Daisuke Kondoh, Yo Ishihara, Hiroyoshi Iwata, Tatsuya Shonaka, Hiromichi Obara, Hiromi Sakai, Hiroyuki Furukawa, Naoto Matsuno
Midthermic machine perfusion (MMP) of post-circulatory arrest donor liver grafts has the advantage of preserving the functional ultrastructure of hepatocytes in donor grafts. It was reported that oxygenation during MMP reduces portal venous resistance and increases bile production. The MMP with hemoglobin-based oxygen vesicles (HbV) keeps the lower aspartate aminotransferase level (an indicator of liver injury) and maintains the functional ultrastructure of mitochondria in the hepatocytes. To evaluated differences of ultrastructural damages in donor livers between the MMP with and without HbV, porcine liver grafts after 60 min of warm ischemia were perfused at 22°C for 4 h with or without HbV, and a part of liver grafts were analyzed by transmission electron microscopy (TEM) and osmium-maceration scanning electron microscopy (OM-SEM)...
September 1, 2023: Microscopy Research and Technique
https://read.qxmd.com/read/37502743/left-rib-fractures-during-cardiopulmonary-resuscitation-are-associated-with-hemodynamic-variations-in-a-pig-model-of-cardiac-arrest
#28
JOURNAL ARTICLE
Deborah Jaeger, Rajat Kalra, Pierre Sebastian, Christopher Gaisendrees, Marinos Kosmopoulos, Guillaume Debaty, Tahar Chouihed, Jason Bartos, Demetris Yannopoulos
BACKGROUND: Chest compressions (CC) are the cornerstone of cardiopulmonary resuscitation (CPR). But CC are also known to cause injuries, specifically rib fractures. The effects of such fractures have not been examined yet. This study aimed to investigate hemodynamic effects of rib fractures during mechanical CPR in a porcine model of cardiac arrest (CA). METHODS: We conducted a retrospective hemodynamic study in 31 pigs that underwent mechanical CC. Animals were divided into three groups based on the location of rib fractures: No Broken Ribs group ( n  = 11), Left Broken Ribs group ( n  = 13), and Right Broken Ribs group ( n  = 7)...
September 2023: Resuscitation plus
https://read.qxmd.com/read/37448689/hands-free-continuous-carotid-doppler-ultrasound-for-detection-of-the-pulse-during-cardiac-arrest-in-a-porcine-model
#29
JOURNAL ARTICLE
Bjørn Ove Faldaas, Erik Waage Nielsen, Benjamin Stage Storm, Knut Tore Lappegård, Ole-Jakob How, Bent Aksel Nilsen, Gabriel Kiss, Eirik Skogvoll, Hans Torp, Charlotte Ingul
BACKGROUND/PURPOSE: Pulse palpation is an unreliable method for diagnosing cardiac arrest. To address this limitation, continuous hemodynamic monitoring may be a viable solution. Therefore, we developed a novel, hands-free Doppler system, RescueDoppler, to detect the pulse continuously in the carotid artery. METHODS: In twelve pigs, we evaluated RescueDoppleŕs potential to measure blood flow velocity in three situations where pulse palpation of the carotid artery was insufficient: (1) systolic blood pressure below 60 mmHg, (2) ventricular fibrillation (VF) and (3) pulseless electrical activity (PEA)...
September 2023: Resuscitation plus
https://read.qxmd.com/read/37308196/-protective-role-and-mechanism-of-tubastatin-a-on-renal-and-intestinal-injuries-after-cardiopulmonary-resuscitation-in-swine
#30
JOURNAL ARTICLE
Xinjie Wu, Xue Zhao, Qijiang Chen, Ying Liu, Jiefeng Xu, Guangju Zhou, Mao Zhang
OBJECTIVE: To investigate the protective effect and potential mechanism of tubastatin A (TubA), a specific inhibitor of histone deacetylase 6 (HDAC6), on renal and intestinal injuries after cardiopulmonary resuscitation (CPR) in swine. METHODS: Twenty-five healthy male white swine were divided into Sham group (n = 6), CPR model group (n = 10) and TubA intervention group (n = 9) using a random number table. The porcine model of CPR was reproduced by 9-minute cardiac arrest induced by electrical stimulation via right ventricle followed by 6-minute CPR...
April 2023: Zhonghua Wei Zhong Bing Ji Jiu Yi Xue
https://read.qxmd.com/read/37211245/mitochondrial-transplantation-preserves-myocardial-function-and-viability-in-pediatric-and-neonatal-pig-hearts-donated-after-circulatory-death
#31
JOURNAL ARTICLE
Victor S Alemany, Rio Nomoto, Mossab Y Saeed, Aybuke Celik, William L Regan, Gregory S Matte, Dominic P Recco, Sitaram M Emani, Pedro J Del Nido, James D McCully
OBJECTIVE: Mitochondrial transplantation has been shown to preserve myocardial function and viability in adult porcine hearts donated after circulatory death (DCD) . Herein, we investigate the efficacy of mitochondrial transplantation for the preservation of myocardial function and viability in neonatal and pediatric porcine DCD heart donation. METHODS: Circulatory death was induced in neonatal and pediatric Yorkshire pigs by cessation of mechanical ventilation...
May 20, 2023: Journal of Thoracic and Cardiovascular Surgery
https://read.qxmd.com/read/37181541/therapeutic-effect-of-argatroban-during-cardiopulmonary-resuscitation-and-streptokinase-during-extracorporeal-cardiopulmonary-resuscitation-in-a-porcine-model-of-prolonged-cardiac-arrest
#32
JOURNAL ARTICLE
Jensyn J VanZalen, Stephen Harvey, Pavel Hála, Annie Phillips, Takahiro Nakashima, Emre Gok, Mohamad Hakam Tiba, Brendan M McCracken, Joseph E Hill, Jinhui Liao, Joshua Jung, Joshua Mergos, William C Stacey, Robert H Bartlett, Cindy H Hsu, Alvaro Rojas-Peña, Robert W Neumar
UNLABELLED: Prolonged cardiac arrest (CA) causes microvascular thrombosis which is a potential barrier to organ reperfusion during extracorporeal cardiopulmonary resuscitation (ECPR). The aim of this study was to test the hypothesis that early intra-arrest anticoagulation during cardiopulmonary resuscitation (CPR) and thrombolytic therapy during ECPR improve recovery of brain and heart function in a porcine model of prolonged out-of-hospital CA. DESIGN: Randomized interventional trial...
May 2023: Critical care explorations
https://read.qxmd.com/read/37115696/cpr-cardiac-phosphatase-in-resuscitation
#33
COMMENT
Arjun Deb
Out-of-hospital cardiac arrest is associated with a dismal mortality rate and low long-term survival. A large pharmacological knowledge gap exists in identifying drugs that preserve neurological function and increase long-term survival after cardiac arrest. In this issue of the JCI, Li, Zhu, and colleagues report on their engineering of a 20-amino acid cell-permeable peptide (TAT-PHLPP9c) that antagonized the phosphatase PHLPP1 and prevented PHLPP1-mediated dephosphorylation and AKT inactivation. TAT-PHLPP9c administration maintained activated AKT after arrest and led to AKT-mediated beneficial effects on the heart, brain, and metabolism, resulting in increased cardiac output and cerebral blood flow and rescue of ATP levels in affected tissues...
May 1, 2023: Journal of Clinical Investigation
https://read.qxmd.com/read/37109258/differences-in-cerebral-oxygenation-in-cardiogenic-and-respiratory-cardiac-arrest-before-during-and-after-cardiopulmonary-resuscitation
#34
JOURNAL ARTICLE
Yasuaki Koyama, Akira Ouchi, Nobutake Shimojo, Yoshiaki Inoue
We compared the changes in cerebral oxygen saturation (ScO2 ) levels during cardiac arrest (CA) events using porcine models of ventricular fibrillation CA (VF-CA) and asphyxial CA (A-CA). Twenty female pigs were randomly divided into VF-CA and A-CA groups. We initiated cardiopulmonary resuscitation (CPR) 4 min after CA and measured the cerebral tissue oxygenation index (TOI) using near-infrared spectroscopy (NIRS) before, during, and after CPR. In both groups, the TOI was the lowest at 3-4 min after pre-CPR phase initiation (VF-CA group: 3...
April 18, 2023: Journal of Clinical Medicine
https://read.qxmd.com/read/37088618/combined-use-of-subnormothermic-extracorporeal-support-and-hypothermic-oxygenated-machine-perfusion-for-liver-graft-after-cardiac-death-in-pigs
#35
JOURNAL ARTICLE
Hiroyoshi Iwata, Tetsuya Nakajo, Hiroki Kaneko, Yuga Okazawa, Nur Khatijah Mohd Zin, Hiroki Bochimoto, Makito Ohashi, Yoko Kawada, Shota Kamikawa, Takahiro Kudo, Yoko Okada, Mizuho Ohara, Hiromichi Obara, Naoto Matsuno
BACKGROUND: The use of grafts from donors after cardiac death (DCD) would greatly contribute to the expansion of the donor organ pool. This study aims to determine the benefits of extracorporeal membrane oxygenation (ECMO) and hypothermic oxygenated machine perfusion (HOPE) in a large animal model of DCD liver. METHODS: After cardiac arrest, the abdominal aorta and the inferior vena cava were cannulated and connected to an ECMO circuit. Porcine livers were perfused in situ with ECMO at 22°C for 60 minutes after 45 minutes of cardiac death...
April 21, 2023: Transplantation Proceedings
https://read.qxmd.com/read/37018832/respiratory-mechanics-and-neural-respiratory-drive-of-untreated-gasping-during-cardiac-arrest-in-a-porcine-model
#36
JOURNAL ARTICLE
Lin Lin, Pengfei Wang, Houzhen Zheng, Zheye Zhong, Yongxun Zhuansun, Zhengfei Yang, Rui Chen
INTRODUCTION: Although the effects on hemodynamics of gasping during cardiac arrest (CA) have received a lot of attention, less is known about the respiratory mechanics and physiology of respiration in gasping. To investigate the respiratory mechanics and neural respiratory drive of gasping during cardiac arrest in a porcine model. METHOD: Pigs weighing 34.9 ± 5.7 kg were anesthetized intravenously. Ventricular fibrillation (VF) was electrically induced and untreated for 10 min...
April 6, 2023: Shock
https://read.qxmd.com/read/36852976/effects-of-mesenchymal-stem-cells-on-post-resuscitation-renal-and-intestinal-injuries-in-a-porcine-cardiac-arrest-model
#37
JOURNAL ARTICLE
Chuang Chen, Shuangshuang Ma, Lyuzhao Liao, Yu Xiao, Haiwen Dai
OBJECTIVES: Systemic ischemia-reperfusion triggered by cardiac arrest (CA) and resuscitation often causes post-resuscitation multiple organ injuries. Mesenchymal stem cells (MSCs) have been proven to be a promising treatment for regional renal and intestinal ischemia reperfusion injuries. This study aimed to investigate the effects of MSCs on renal and intestinal injuries following cardiopulmonary resuscitation (CPR) in a porcine CA model. METHODS: Twenty-two male pigs were randomly assigned to the sham (n = 6), CA/CPR (n = 8), and CA/CPR + MSC (n = 8) groups...
March 1, 2023: Shock
https://read.qxmd.com/read/36831121/pupillary-light-response-deficits-in-4-week-old-piglets-and-adolescent-children-after-low-velocity-head-rotations-and-sports-related-concussions
#38
JOURNAL ARTICLE
Anna Oeur, Mackenzie Mull, Giancarlo Riccobono, Kristy B Arbogast, Kenneth J Ciuffreda, Nabin Joshi, Daniele Fedonni, Christina L Master, Susan S Margulies
Neurological disorders and traumatic brain injury (TBI) are among the leading causes of death and disability. The pupillary light reflex (PLR) is an emerging diagnostic tool for concussion in humans. We compared PLR obtained with a commercially available pupillometer in the 4 week old piglet model of the adolescent brain subject to rapid nonimpact head rotation (RNR), and in human adolescents with and without sports-related concussion (SRC). The 95% PLR reference ranges (RR, for maximum and minimum pupil diameter, latency, and average and peak constriction velocities) were established in healthy piglets (N = 13), and response reliability was validated in nine additional healthy piglets...
February 16, 2023: Biomedicines
https://read.qxmd.com/read/36789866/pediatric-extracorporeal-cardiopulmonary-resuscitation-development-of-a-porcine-model-and-the-influence-of-cardiopulmonary-resuscitation-duration-on-brain-injury
#39
RANDOMIZED CONTROLLED TRIAL
Julia C Slovis, Lindsay Volk, Constantine Mavroudis, Marco Hefti, William P Landis, Anna L Roberts, Nile Delso, Thomas Hallowell, Kathryn Graham, Jonathan Starr, Yuxi Lin, Richard Melchior, Vinay Nadkarni, Robert M Sutton, Robert A Berg, Sarah Piel, Ryan W Morgan, Todd J Kilbaugh
Background The primary objective was to develop a porcine model of prolonged (30 or 60 minutes) pediatric cardiopulmonary resuscitation (CPR) followed by 22- to 24-hour survival with extracorporeal life support, and secondarily to evaluate differences in neurologic injury. Methods and Results Ten-kilogram, 4-week-old female piglets were used. First, model development established the technique (n=8). Then, a pilot study was conducted (n=15). After 80% survival was achieved in the final 5 pilot animals, a proof-of-concept randomized study was completed (n=11)...
February 21, 2023: Journal of the American Heart Association
https://read.qxmd.com/read/36736947/high-central-venous-pressure-amplitude-predicts-successful-defibrillation-in-a-porcine-model-of-cardiac-arrest
#40
JOURNAL ARTICLE
Claudius Balzer, Susan S Eagle, Demetris Yannopoulos, Tom P Aufderheide, Matthias L Riess
AIM: Increasing venous return during cardiopulmonary resuscitation (CPR) has been shown to improve hemodynamics during CPR and outcomes following cardiac arrest (CA). We hypothesized that a high central venous pressure amplitude (CVP-A), the difference between the maximum and minimum central venous pressure during chest compressions, could serve as a robust predictor of return of spontaneous circulation (ROSC) in addition to traditional measurements of coronary perfusion pressure (CPP) and end-tidal CO2 (etCO2 ) in a porcine model of CA...
February 2, 2023: Resuscitation
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