Julia C Slovis, Lindsay Volk, Constantine Mavroudis, Marco Hefti, William P Landis, Anna L Roberts, Nile Delso, Thomas Hallowell, Kathryn Graham, Jonathan Starr, Yuxi Lin, Richard Melchior, Vinay Nadkarni, Robert M Sutton, Robert A Berg, Sarah Piel, Ryan W Morgan, Todd J Kilbaugh
Background The primary objective was to develop a porcine model of prolonged (30 or 60 minutes) pediatric cardiopulmonary resuscitation (CPR) followed by 22- to 24-hour survival with extracorporeal life support, and secondarily to evaluate differences in neurologic injury. Methods and Results Ten-kilogram, 4-week-old female piglets were used. First, model development established the technique (n=8). Then, a pilot study was conducted (n=15). After 80% survival was achieved in the final 5 pilot animals, a proof-of-concept randomized study was completed (n=11)...
February 21, 2023: Journal of the American Heart Association