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https://www.readbyqxmd.com/read/27850005/365-changes-in-central-respiratory-drive-of-gasping-in-a-porcine-model-of-cardiac-arrest
#1
Houzhen Zheng, Rui Chen, Zhengfei Yang, Wanchun Tang
No abstract text is available yet for this article.
December 2016: Critical Care Medicine
https://www.readbyqxmd.com/read/27849923/281-relationship-of-loi-and-brain-dysfunction-after-resuscitation-in-a-porcine-model-of-cardiac-arrest
#2
Xiaozhu Zhai, Longyuan Jiang, Zhengfei Yang, Cai Wen, Houzhen Zheng, Tao Yu, Mary Peberdy, Wanchun Tang
No abstract text is available yet for this article.
December 2016: Critical Care Medicine
https://www.readbyqxmd.com/read/27849737/57-inhalation-of-hydrogen-improves-neurologic-injuries-in-a-porcine-model-of-prolonged-cardiac-arrest
#3
Zhangle Hu, Tao Yu, Zhengfei Yang, Wanchun Tang
No abstract text is available yet for this article.
December 2016: Critical Care Medicine
https://www.readbyqxmd.com/read/27771299/sodium-nitroprusside-enhanced-cardiopulmonary-resuscitation-improves-short-term-survival-in-a-porcine-model-of-ischemic-refractory-ventricular-fibrillation
#4
Demetris Yannopoulos, Jason A Bartos, Stephen A George, George Sideris, Sebastian Voicu, Brett Oestreich, Timothy Matsuura, Kadambari Shekar, Jennifer Rees, Tom P Aufderheide
INTRODUCTION: Sodium nitroprusside (SNP) enhanced CPR (SNPeCPR) demonstrates increased vital organ blood flow and survival in multiple porcine models. We developed a new, coronary occlusion/ischemia model of prolonged resuscitation, mimicking the majority of out-of-hospital cardiac arrests presenting with shockable rhythms. HYPOTHESIS: SNPeCPR will increase short term (4-h) survival compared to standard 2015 Advanced Cardiac Life Support (ACLS) guidelines in an ischemic refractory ventricular fibrillation (VF), prolonged CPR model...
October 19, 2016: Resuscitation
https://www.readbyqxmd.com/read/27742245/airway-pressure-release-ventilation-during-ex%C3%A2-vivo-lung-perfusion-attenuates-injury
#5
J Hunter Mehaffey, Eric J Charles, Ashish K Sharma, Dustin T Money, Yunge Zhao, Mark H Stoler, Christine L Lau, Curtis G Tribble, Victor E Laubach, Mark E Roeser, Irving L Kron
OBJECTIVE: Critical organ shortages have resulted in ex vivo lung perfusion gaining clinical acceptance for lung evaluation and rehabilitation to expand the use of donation after circulatory death organs for lung transplantation. We hypothesized that an innovative use of airway pressure release ventilation during ex vivo lung perfusion improves lung function after transplantation. METHODS: Two groups (n = 4 animals/group) of porcine donation after circulatory death donor lungs were procured after hypoxic cardiac arrest and a 2-hour period of warm ischemia, followed by a 4-hour period of ex vivo lung perfusion rehabilitation with standard conventional volume-based ventilation or pressure-based airway pressure release ventilation...
September 22, 2016: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/27718228/prediction-of-renal-function-upon-reperfusion-by-ex-situ-controlled-oxygenated-rewarming
#6
Thomas Minor, Katja Sutschet, Oliver Witzke, Andreas Paul, Anja Gallinat
BACKGROUND: Post-transplant function of suboptimal kidney grafts can be improved but not accurately predicted by hypothermic machine perfusion. Therefore, a new concept of ex situ pre-implantation machine perfusion with controlled rewarming up to subnormothermic temperatures was developed and evaluated. MATERIALS AND METHODS: Porcine kidneys (n = 6/group) were retrieved before or 30 min after cardiac arrest of the donor and subjected to 18 h of static cold storage...
December 2016: European Journal of Clinical Investigation
https://www.readbyqxmd.com/read/27635468/rapid-induction-of-therapeutic-hypothermia-using-transnasal-high-flow-dry-air
#7
Raghuram Chava, Menekhem Zviman, Madhavan Srinivas Raghavan, Henry Halperin, Farhan Maqbool, Romergryko Geocadin, Alfredo Quinones-Hinojosa, Aravindan Kolandaivelu, Benjamin A Rosen, Harikrishna Tandri
Early induction of therapeutic hypothermia (TH) is recommended in out-of-hospital cardiac arrest (CA); however, currently no reliable methods exist to initiate cooling. We investigated the effect of high flow transnasal dry air on brain and body temperatures in adult porcine animals. Adult porcine animals (n = 23) under general anesthesia were subject to high flow of transnasal dry air. Mouth was kept open to create a unidirectional airflow, in through the nostrils and out through the mouth. Brain, internal jugular, and aortic temperatures were recorded...
September 16, 2016: Therapeutic Hypothermia and Temperature Management
https://www.readbyqxmd.com/read/27614966/effects-of-shenfu-injection-on-cerebral-metabolism-in-a-porcine-model-of-cardiac-arrest
#8
Qin Yin, Cai-Jun Wu, Jun Yang, Chen-Chen Hang, Chun-Sheng Li
OBJECTIVE: To investigate the effects of Shenfu Injection (, SFI) on cerebral metabolism in a porcine model of cardiac arrest (CA). METHODS: Thirty Wuzhishan minipigs were randomly assigned to the control group (n=6), epinephrine group (EP group, n=12) and Sfigroup (n=12). After 8 min of untreated ventricular fifibrillation (VF), pigs in the EP group or Sfigroup were administered with either EP (0.02 mg/kg) or Sfi(1.0 mL/kg), respectively. After successful resuscitation, cerebrospinal fluid (CSF) levels of glucose, pyruvate, lactate, glutamate and glycerol were measured at 1, 6, 12 and 24 h after recover from spontaneous circulation (ROSC)...
September 10, 2016: Chinese Journal of Integrative Medicine
https://www.readbyqxmd.com/read/27614451/effects-of-shen-fu-injection-on-apoptosis-of-regulatory-t-lymphocytes-in-spleen-during-post-resuscitation-immune-dysfunction-in-a-porcine-model-of-cardiac-arrest
#9
Wei Gu, Qian Zhang, Chun-Sheng Li
OBJECTIVE: To investigate whether Shen-Fu Injection (, SFI) reduces post-resuscitation immune dysfunction in a porcine model of cardiac arrest by modulating apoptosis of regulatory T lymphocytes (Treg) in the spleen. METHODS: After 8-min untreated ventricular fibrillation and 2-min basic life support, 24 pigs were divided into 3 groups with a random number table, i.e. SFI group, epinephrine (EP) group, and saline (SA) group (8 in each group), which received central venous injection of SFI (1...
September 2016: Chinese Journal of Integrative Medicine
https://www.readbyqxmd.com/read/27521963/carvedilol-enriched-cold-oxygenated-blood-cardioplegia-improves-left-ventricular-diastolic-function-after-weaning-from-cardiopulmonary-bypass
#10
Geir Olav Dahle, Pirjo-Riitta Salminen, Christian Arvei Moen, Finn Eliassen, Else Nygreen, Ville Kytö, Pekka Saukko, Rune Haaverstad, Knut Matre, Ketil Grong
OBJECTIVES: To investigate whether adding carvedilol, a nonselective β- and selective α1-receptor blocking agent with antioxidant properties, to oxygenated blood cardioplegia improves myocardial function after weaning from bypass. DESIGN: A randomized controlled study. SETTING: A university laboratory. PARTICIPANTS: Twenty anesthetized pigs, Norwegian Landrace. INTERVENTIONS: On cardiopulmonary bypass, cardiac arrest was induced with cold (12°C), oxygenated blood cardioplegia, enriched with carvedilol or vehicle, and repeated every 20 minutes...
August 2016: Journal of Cardiothoracic and Vascular Anesthesia
https://www.readbyqxmd.com/read/27514498/steroids-can-reduce-warm-ischemic-reperfusion-injury-in-a-porcine-dcd-model-with-evlp-evaluation
#11
An Martens, Marc Boada, Bart M Vanaudenaerde, Stijn E Verleden, Robin Vos, Geert M Verleden, Eric K Verbeken, Dirk Van Raemdonck, Dominique Schols, Sandra Claes, Arne P Neyrinck
Donation after circulatory death (DCD) is being used to increase the number of transplantable organs. The role and timing of steroids in DCD donation and ex-vivo lung perfusion (EVLP) has not been thoroughly investigated. In this study, we investigated the effect of steroids on warm-ischemic injury in a porcine model (n=6/group). Following cardiac arrest, grafts were left untouched in the donor (90 minutes warm ischemia). Graft function was assessed after 6 hours of EVLP. In MP-group, 500 mg methylprednisolone was given prior to cardiac arrest and during EVLP...
August 12, 2016: Transplant International: Official Journal of the European Society for Organ Transplantation
https://www.readbyqxmd.com/read/27449068/captopril-improves-postresuscitation-hemodynamics-protective-against-pulmonary-embolism-by-activating-the-ace2-ang-1-7-mas-axis
#12
Hong-Li Xiao, Chun-Sheng Li, Lian-Xing Zhao, Jun Yang, Nan Tong, Le An, Qi-Tong Liu
Acute pulmonary embolism (APE) has a very high mortality rate, especially at cardiac arrest and even after the return of spontaneous circulation (ROSC). This study investigated the protective effect of the angiotensin-converting enzyme (ACE) inhibitor captopril on postresuscitation hemodynamics, in a porcine model of cardiac arrest established by APE. Twenty-nine Beijing Landrace pigs were infused with an autologous thrombus leading to cardiac arrest and subjected to standard cardiopulmonary resuscitation and thrombolysis...
November 2016: Naunyn-Schmiedeberg's Archives of Pharmacology
https://www.readbyqxmd.com/read/27414479/blood-pressure-and-coronary-perfusion-pressure-targeted-cardiopulmonary-resuscitation-improves-24-hour-survival-from-ventricular-fibrillation-cardiac-arrest
#13
Maryam Y Naim, Robert M Sutton, Stuart H Friess, George Bratinov, Utpal Bhalala, Todd J Kilbaugh, Joshua W Lampe, Vinay M Nadkarni, Lance B Becker, Robert A Berg
OBJECTIVES: Treatment algorithms for cardiac arrest are rescuer centric and vary little from patient to patient. The objective of this study was to determine if cardiopulmonary resuscitation-targeted to arterial blood pressure and coronary perfusion pressure rather than optimal guideline care would improve 24-hour survival in a porcine model of ventricular fibrillation cardiac arrest. DATA SOURCES: Preclinical animal laboratory using female 3-month-old swine. STUDY SELECTION: A randomized interventional study...
November 2016: Critical Care Medicine
https://www.readbyqxmd.com/read/27391370/cardiopulmonary-responses-during-the-cooling-and-the-extracorporeal-life-support-rewarming-phases-in-a-porcine-model-of-accidental-deep-hypothermic-cardiac-arrest
#14
Guillaume Debaty, Maxime Maignan, Bertrand Perrin, Angélique Brouta, Dorra Guergour, Candice Trocme, Vincent Bach, Stéphane Tanguy, Raphaël Briot
BACKGROUND: This study aimed to assess cardiac and pulmonary pathophysiological responses during cooling and extracorporeal life support (ECLS) rewarming in a porcine model of deep hypothermic cardiac arrest (DHCA). In addition, we evaluated whether providing a lower flow rate of ECLS during the rewarming phase might attenuate cardiopulmonary injuries. METHODS: Twenty pigs were cannulated for ECLS, cooled until DHCA occurred and subjected to 30 min of cardiac arrest...
2016: Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine
https://www.readbyqxmd.com/read/27364795/effect-of-splenic-regulatory-t-cell-apoptosis-on-the-postresuscitation-immune-dysfunction-in-a-porcine-model
#15
Wei Gu, Qian Zhang, Chun-Sheng Li
BACKGROUND: Postresuscitation immune dysfunction contributes to the low survival rate after successful resuscitation, but its mechanism remains poorly understood. The purpose of this study was to investigate whether splenic regulatory T-cell (Treg) apoptosis was involved in the postresuscitation immune dysfunction. METHODS: Thirty-eight pigs were randomly divided into sham-operated group (SHAM group, n = 8), 12 h post return of spontaneous circulation (ROSC) group, 24 h post-ROSC group, and 48 h post-ROSC group (n = 10 per group)...
July 5, 2016: Chinese Medical Journal
https://www.readbyqxmd.com/read/27364794/study-of-cardiac-arrest-caused-by-acute-pulmonary-thromboembolism-and-thrombolytic-resuscitation-in-a-porcine-model
#16
Lian-Xing Zhao, Chun-Sheng Li, Jun Yang, Nan Tong, Hong-Li Xiao, Le An
BACKGROUND: The success rate of resuscitation in cardiac arrest (CA) caused by pulmonary thromboembolism (PTE) is low. Furthermore, there are no large animal models that simulate clinical CA. The aim of this study was to establish a porcine CA model caused by PTE and to investigate the pathophysiology of CA and postresuscitation. METHODS: This model was induced in castrated male pigs (30 ± 2 kg; n = 21) by injecting thrombi (10-15 ml) via the left external jugular vein...
July 5, 2016: Chinese Medical Journal
https://www.readbyqxmd.com/read/27320594/applicability-of-combined-use-of-extracorporeal-support-and-temperature-controlled-machine-perfusion-preservation-for-liver-procurement-of-donors-after-cardiac-death-in-pigs
#17
M Hagiwara, N Matsuno, L T Meng, M Furukori, K Watanabe, T Shonaka, K Imai, H Obara, Y Nishikawa, H Furukawa
BACKGROUND: The use of grafts from donors after cardiac death (DCD) would greatly contribute to the expansion of the donor organ pool. The objective of this study is to determine the benefits of extracorporeal membrane oxygenation (ECMO) and subnormothermic machine perfusion (MP) with rewarming in a large animal model of DCD liver. METHODS: After cardiac arrest, the abdominal aorta and the inferior vena cava were cannulated and connected to an ECMO circuit. Porcine livers were perfused in situ with ECMO at 22°C for 60 minutes after 60 minutes of cardiac death...
May 2016: Transplantation Proceedings
https://www.readbyqxmd.com/read/27277706/microcirculatory-blood-flow-during-cardiac-arrest-and-cardiopulmonary-resuscitation-does-not-correlate-with-global-hemodynamics-an-experimental-study
#18
Petra Krupičková, Mikuláš Mlček, Michal Huptych, Zuzana Mormanová, Tomáš Bouček, Tomáš Belza, Stanislav Lacko, Miloš Černý, Petr Neužil, Otomar Kittnar, Aleš Linhart, Jan Bělohlávek
BACKGROUND: Current research highlights the role of microcirculatory disorders in post-cardiac arrest patients. Affected microcirculation shows not only dissociation from systemic hemodynamics but also strong connection to outcome of these patients. However, only few studies evaluated microcirculation directly during cardiac arrest (CA) and cardiopulmonary resuscitation (CPR). The aim of our experimental study in a porcine model was to describe sublingual microcirculatory changes during CA and CPR using recent videomicroscopic technology and provide a comparison to parameters of global hemodynamics...
2016: Journal of Translational Medicine
https://www.readbyqxmd.com/read/27211835/reperfusion-injury-protection-during-basic-life-support-improves-circulation-and-survival-outcomes-in-a-porcine-model-of-prolonged-cardiac-arrest
#19
Guillaume Debaty, Keith Lurie, Anja Metzger, Michael Lick, Jason A Bartos, Jennifer N Rees, Scott McKnite, Laura Puertas, Paul Pepe, Raymond Fowler, Demetris Yannopoulos
OBJECTIVE: Ischemic postconditioning (PC) using three intentional pauses at the start of cardiopulmonary resuscitation (CPR) improves outcomes after cardiac arrest in pigs when epinephrine (epi) is used before defibrillation. We hypothesized PC, performed during basic life support (BLS) in the absence of epinephrine, would reduce reperfusion injury and enhance 24h functional recovery. DESIGN: Prospective animal investigation. SETTING: Animal laboratory SUBJECTS: Female farm pigs (n=46, 39±1kg)...
August 2016: Resuscitation
https://www.readbyqxmd.com/read/27168071/influence-of-chest-compressions-on-circulation-during-the-peri-cardiac-arrest-period-in-porcine-models
#20
Jun Xu, Chen Li, Yan Li, Joseph Walline, Liangliang Zheng, Yangyang Fu, Dongqi Yao, Huadong Zhu, Xiaohe Liu, Yanfen Chai, Zhong Wang, Xuezhong Yu
OBJECTIVE: Starting chest compressions immediately after a defibrillation shock might be harmful, if the victim already had a return of spontaneous circulation (ROSC) and yet was still being subjected to external compressions at the same time. The objective of this study was to study the influence of chest compressions on circulation during the peri-cardiac arrest period. DESIGN: Prospective, randomized controlled study. SETTING: Animal experimental center in Peking Union Medical Collage Hospital, Beijing, China...
2016: PloS One
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