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https://www.readbyqxmd.com/read/28007740/early-coronary-reperfusion-facilitates-return-of-spontaneous-circulation-and-improves-cardiovascular-outcomes-after-ischemic-cardiac-arrest-and-extracorporeal-resuscitation-in-pigs
#1
Alice Hutin, Lionel Lamhaut, Fanny Lidouren, Matthias Kohlhauer, Nicolas Mongardon, Pierre Carli, Alain Berdeaux, Bijan Ghaleh, Renaud Tissier
BACKGROUND: Extracorporeal cardiopulmonary resuscitation (ECPR) is widely proposed for the treatment of refractory cardiac arrest. It should be associated with coronary angiography if coronary artery disease is suspected. However, the prioritization of care remains unclear in this situation. Our goal was to determine whether coronary reperfusion should be instituted as soon as possible in such situations in a pig model. METHODS AND RESULTS: Anesthetized pigs were instrumented and submitted to coronary artery occlusion and ventricular fibrillation...
December 22, 2016: Journal of the American Heart Association
https://www.readbyqxmd.com/read/27987159/a-novel-nonlinear-mathematical-model-of-thoracic-wall-mechanics-during-cardiopulmonary-resuscitation-based-on-a-porcine-model-of-cardiac-arrest
#2
Ali Jalali, Allan F Simpao, Vinay M Nadkarni, Robert A Berg, C Nataraj
Cardiopulmonary resuscitation (CPR) is used widely to rescue cardiac arrest patients, yet some physiological aspects of the procedure remain poorly understood. We conducted this study to characterize the dynamic mechanical properties of the thorax during CPR in a swine model. This is an important step toward determining optimal CPR chest compression mechanics with the goals of improving the fidelity of CPR simulation manikins and ideally chest compression delivery in real-life resuscitations. This paper presents a novel nonlinear model of the thorax that captures the complex behavior of the chest during CPR...
February 2017: Journal of Medical Systems
https://www.readbyqxmd.com/read/27941230/the-possible-role-of-the-vagal-nervous-system-in-the-recovery-of-the-blood-pressure-control-after-cardiac-arrest-a-porcine-model-study
#3
Mario Lavanga, Giuseppe Baselli, Francesca Fumagalli, Giuseppe Ristagno, Manuela Ferrario
Previous studies have proved that the baroreceptor reflex (baroreflex) control of heart rate can be used for stratification of post-infarction population and, in general, cardiovascular disease populations. Many methods have been proposed to estimate the so-called baroreflex sensitivity (BRS) expressed as ms mmhg(-1). Most of the studies that exploit BRS focus mainly on acute myocardial infarction (AMI) and there are no important works that investigate the role of BRS immediately after cardiac arrest (CA). The present work is a continuation of the published work of Ristagno et al (2014 Shock 41 72-8)...
January 2017: Physiological Measurement
https://www.readbyqxmd.com/read/27923692/a-hemodynamic-directed-approach-to-pediatric-cardiopulmonary-resuscitation-hd-cpr-improves-survival
#4
Ryan W Morgan, Todd J Kilbaugh, Wesley Shoap, George Bratinov, Yuxi Lin, Ting-Chang Hsieh, Vinay M Nadkarni, Robert A Berg, Robert M Sutton
AIM: Most pediatric in-hospital cardiac arrests (IHCAs) occur in ICUs where invasive hemodynamic monitoring is frequently available. Titrating cardiopulmonary resuscitation (CPR) to the hemodynamic response of the individual improves survival in preclinical models of adult cardiac arrest. The objective of this study was to determine if titrating CPR to systolic blood pressure (SBP) and coronary perfusion pressure (CoPP) in a pediatric porcine model of asphyxia-associated ventricular fibrillation (VF) IHCA would improve survival as compared to traditional CPR...
February 2017: Resuscitation
https://www.readbyqxmd.com/read/27850005/365-changes-in-central-respiratory-drive-of-gasping-in-a-porcine-model-of-cardiac-arrest
#5
Houzhen Zheng, Rui Chen, Zhengfei Yang, Wanchun Tang
No abstract text is available yet for this article.
December 2016: Critical Care Medicine
https://www.readbyqxmd.com/read/27849923/281-relationship-of-loi-and-brain-dysfunction-after-resuscitation-in-a-porcine-model-of-cardiac-arrest
#6
Xiaozhu Zhai, Longyuan Jiang, Zhengfei Yang, Cai Wen, Houzhen Zheng, Tao Yu, Mary Peberdy, Wanchun Tang
No abstract text is available yet for this article.
December 2016: Critical Care Medicine
https://www.readbyqxmd.com/read/27849737/57-inhalation-of-hydrogen-improves-neurologic-injuries-in-a-porcine-model-of-prolonged-cardiac-arrest
#7
Zhangle Hu, Tao Yu, Zhengfei Yang, Wanchun Tang
No abstract text is available yet for this article.
December 2016: Critical Care Medicine
https://www.readbyqxmd.com/read/27771299/sodium-nitroprusside-enhanced-cardiopulmonary-resuscitation-improves-short-term-survival-in-a-porcine-model-of-ischemic-refractory-ventricular-fibrillation
#8
Demetris Yannopoulos, Jason A Bartos, Stephen A George, George Sideris, Sebastian Voicu, Brett Oestreich, Timothy Matsuura, Kadambari Shekar, Jennifer Rees, Tom P Aufderheide
INTRODUCTION: Sodium nitroprusside (SNP) enhanced CPR (SNPeCPR) demonstrates increased vital organ blood flow and survival in multiple porcine models. We developed a new, coronary occlusion/ischemia model of prolonged resuscitation, mimicking the majority of out-of-hospital cardiac arrests presenting with shockable rhythms. HYPOTHESIS: SNPeCPR will increase short term (4-h) survival compared to standard 2015 Advanced Cardiac Life Support (ACLS) guidelines in an ischemic refractory ventricular fibrillation (VF), prolonged CPR model...
January 2017: Resuscitation
https://www.readbyqxmd.com/read/27742245/airway-pressure-release-ventilation-during-ex%C3%A2-vivo-lung-perfusion-attenuates-injury
#9
J Hunter Mehaffey, Eric J Charles, Ashish K Sharma, Dustin T Money, Yunge Zhao, Mark H Stoler, Christine L Lau, Curtis G Tribble, Victor E Laubach, Mark E Roeser, Irving L Kron
OBJECTIVE: Critical organ shortages have resulted in ex vivo lung perfusion gaining clinical acceptance for lung evaluation and rehabilitation to expand the use of donation after circulatory death organs for lung transplantation. We hypothesized that an innovative use of airway pressure release ventilation during ex vivo lung perfusion improves lung function after transplantation. METHODS: Two groups (n = 4 animals/group) of porcine donation after circulatory death donor lungs were procured after hypoxic cardiac arrest and a 2-hour period of warm ischemia, followed by a 4-hour period of ex vivo lung perfusion rehabilitation with standard conventional volume-based ventilation or pressure-based airway pressure release ventilation...
January 2017: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/27718228/prediction-of-renal-function-upon-reperfusion-by-ex-situ-controlled-oxygenated-rewarming
#10
Thomas Minor, Katja Sutschet, Oliver Witzke, Andreas Paul, Anja Gallinat
BACKGROUND: Post-transplant function of suboptimal kidney grafts can be improved but not accurately predicted by hypothermic machine perfusion. Therefore, a new concept of ex situ pre-implantation machine perfusion with controlled rewarming up to subnormothermic temperatures was developed and evaluated. MATERIALS AND METHODS: Porcine kidneys (n = 6/group) were retrieved before or 30 min after cardiac arrest of the donor and subjected to 18 h of static cold storage...
December 2016: European Journal of Clinical Investigation
https://www.readbyqxmd.com/read/27635468/rapid-induction-of-therapeutic-hypothermia-using-transnasal-high-flow-dry-air
#11
Raghuram Chava, Menekhem Zviman, Madhavan Srinivas Raghavan, Henry Halperin, Farhan Maqbool, Romergryko Geocadin, Alfredo Quinones-Hinojosa, Aravindan Kolandaivelu, Benjamin A Rosen, Harikrishna Tandri
Early induction of therapeutic hypothermia (TH) is recommended in out-of-hospital cardiac arrest (CA); however, currently no reliable methods exist to initiate cooling. We investigated the effect of high flow transnasal dry air on brain and body temperatures in adult porcine animals. Adult porcine animals (n = 23) under general anesthesia were subject to high flow of transnasal dry air. Mouth was kept open to create a unidirectional airflow, in through the nostrils and out through the mouth. Brain, internal jugular, and aortic temperatures were recorded...
September 16, 2016: Therapeutic Hypothermia and Temperature Management
https://www.readbyqxmd.com/read/27614966/effects-of-shenfu-injection-on-cerebral-metabolism-in-a-porcine-model-of-cardiac-arrest
#12
Qin Yin, Cai-Jun Wu, Jun Yang, Chen-Chen Hang, Chun-Sheng Li
OBJECTIVE: To investigate the effects of Shenfu Injection (, SFI) on cerebral metabolism in a porcine model of cardiac arrest (CA). METHODS: Thirty Wuzhishan minipigs were randomly assigned to the control group (n=6), epinephrine group (EP group, n=12) and Sfigroup (n=12). After 8 min of untreated ventricular fifibrillation (VF), pigs in the EP group or Sfigroup were administered with either EP (0.02 mg/kg) or Sfi(1.0 mL/kg), respectively. After successful resuscitation, cerebrospinal fluid (CSF) levels of glucose, pyruvate, lactate, glutamate and glycerol were measured at 1, 6, 12 and 24 h after recover from spontaneous circulation (ROSC)...
September 10, 2016: Chinese Journal of Integrative Medicine
https://www.readbyqxmd.com/read/27614451/effects-of-shen-fu-injection-on-apoptosis-of-regulatory-t-lymphocytes-in-spleen-during-post-resuscitation-immune-dysfunction-in-a-porcine-model-of-cardiac-arrest
#13
Wei Gu, Qian Zhang, Chun-Sheng Li
OBJECTIVE: To investigate whether Shen-Fu Injection (, SFI) reduces post-resuscitation immune dysfunction in a porcine model of cardiac arrest by modulating apoptosis of regulatory T lymphocytes (Treg) in the spleen. METHODS: After 8-min untreated ventricular fibrillation and 2-min basic life support, 24 pigs were divided into 3 groups with a random number table, i.e. SFI group, epinephrine (EP) group, and saline (SA) group (8 in each group), which received central venous injection of SFI (1...
September 2016: Chinese Journal of Integrative Medicine
https://www.readbyqxmd.com/read/27521963/carvedilol-enriched-cold-oxygenated-blood-cardioplegia-improves-left-ventricular-diastolic-function-after-weaning-from-cardiopulmonary-bypass
#14
Geir Olav Dahle, Pirjo-Riitta Salminen, Christian Arvei Moen, Finn Eliassen, Else Nygreen, Ville Kytö, Pekka Saukko, Rune Haaverstad, Knut Matre, Ketil Grong
OBJECTIVES: To investigate whether adding carvedilol, a nonselective β- and selective α1-receptor blocking agent with antioxidant properties, to oxygenated blood cardioplegia improves myocardial function after weaning from bypass. DESIGN: A randomized controlled study. SETTING: A university laboratory. PARTICIPANTS: Twenty anesthetized pigs, Norwegian Landrace. INTERVENTIONS: On cardiopulmonary bypass, cardiac arrest was induced with cold (12°C), oxygenated blood cardioplegia, enriched with carvedilol or vehicle, and repeated every 20 minutes...
August 2016: Journal of Cardiothoracic and Vascular Anesthesia
https://www.readbyqxmd.com/read/27514498/steroids-can-reduce-warm-ischemic-reperfusion-injury-in-a-porcine-dcd-model-with-evlp-evaluation
#15
An Martens, Marc Boada, Bart M Vanaudenaerde, Stijn E Verleden, Robin Vos, Geert M Verleden, Eric K Verbeken, Dirk Van Raemdonck, Dominique Schols, Sandra Claes, Arne P Neyrinck
Donation after circulatory death (DCD) is being used to increase the number of transplantable organs. The role and timing of steroids in DCD donation and ex-vivo lung perfusion (EVLP) has not been thoroughly investigated. In this study, we investigated the effect of steroids on warm-ischemic injury in a porcine model (n=6/group). Following cardiac arrest, grafts were left untouched in the donor (90 minutes warm ischemia). Graft function was assessed after 6 hours of EVLP. In MP-group, 500 mg methylprednisolone was given prior to cardiac arrest and during EVLP...
August 12, 2016: Transplant International: Official Journal of the European Society for Organ Transplantation
https://www.readbyqxmd.com/read/27449068/captopril-improves-postresuscitation-hemodynamics-protective-against-pulmonary-embolism-by-activating-the-ace2-ang-1-7-mas-axis
#16
Hong-Li Xiao, Chun-Sheng Li, Lian-Xing Zhao, Jun Yang, Nan Tong, Le An, Qi-Tong Liu
Acute pulmonary embolism (APE) has a very high mortality rate, especially at cardiac arrest and even after the return of spontaneous circulation (ROSC). This study investigated the protective effect of the angiotensin-converting enzyme (ACE) inhibitor captopril on postresuscitation hemodynamics, in a porcine model of cardiac arrest established by APE. Twenty-nine Beijing Landrace pigs were infused with an autologous thrombus leading to cardiac arrest and subjected to standard cardiopulmonary resuscitation and thrombolysis...
November 2016: Naunyn-Schmiedeberg's Archives of Pharmacology
https://www.readbyqxmd.com/read/27414479/blood-pressure-and-coronary-perfusion-pressure-targeted-cardiopulmonary-resuscitation-improves-24-hour-survival-from-ventricular-fibrillation-cardiac-arrest
#17
Maryam Y Naim, Robert M Sutton, Stuart H Friess, George Bratinov, Utpal Bhalala, Todd J Kilbaugh, Joshua W Lampe, Vinay M Nadkarni, Lance B Becker, Robert A Berg
OBJECTIVES: Treatment algorithms for cardiac arrest are rescuer centric and vary little from patient to patient. The objective of this study was to determine if cardiopulmonary resuscitation-targeted to arterial blood pressure and coronary perfusion pressure rather than optimal guideline care would improve 24-hour survival in a porcine model of ventricular fibrillation cardiac arrest. DATA SOURCES: Preclinical animal laboratory using female 3-month-old swine. STUDY SELECTION: A randomized interventional study...
November 2016: Critical Care Medicine
https://www.readbyqxmd.com/read/27391370/cardiopulmonary-responses-during-the-cooling-and-the-extracorporeal-life-support-rewarming-phases-in-a-porcine-model-of-accidental-deep-hypothermic-cardiac-arrest
#18
Guillaume Debaty, Maxime Maignan, Bertrand Perrin, Angélique Brouta, Dorra Guergour, Candice Trocme, Vincent Bach, Stéphane Tanguy, Raphaël Briot
BACKGROUND: This study aimed to assess cardiac and pulmonary pathophysiological responses during cooling and extracorporeal life support (ECLS) rewarming in a porcine model of deep hypothermic cardiac arrest (DHCA). In addition, we evaluated whether providing a lower flow rate of ECLS during the rewarming phase might attenuate cardiopulmonary injuries. METHODS: Twenty pigs were cannulated for ECLS, cooled until DHCA occurred and subjected to 30 min of cardiac arrest...
July 8, 2016: Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine
https://www.readbyqxmd.com/read/27364795/effect-of-splenic-regulatory-t-cell-apoptosis-on-the-postresuscitation-immune-dysfunction-in-a-porcine-model
#19
Wei Gu, Qian Zhang, Chun-Sheng Li
BACKGROUND: Postresuscitation immune dysfunction contributes to the low survival rate after successful resuscitation, but its mechanism remains poorly understood. The purpose of this study was to investigate whether splenic regulatory T-cell (Treg) apoptosis was involved in the postresuscitation immune dysfunction. METHODS: Thirty-eight pigs were randomly divided into sham-operated group (SHAM group, n = 8), 12 h post return of spontaneous circulation (ROSC) group, 24 h post-ROSC group, and 48 h post-ROSC group (n = 10 per group)...
July 5, 2016: Chinese Medical Journal
https://www.readbyqxmd.com/read/27364794/study-of-cardiac-arrest-caused-by-acute-pulmonary-thromboembolism-and-thrombolytic-resuscitation-in-a-porcine-model
#20
Lian-Xing Zhao, Chun-Sheng Li, Jun Yang, Nan Tong, Hong-Li Xiao, Le An
BACKGROUND: The success rate of resuscitation in cardiac arrest (CA) caused by pulmonary thromboembolism (PTE) is low. Furthermore, there are no large animal models that simulate clinical CA. The aim of this study was to establish a porcine CA model caused by PTE and to investigate the pathophysiology of CA and postresuscitation. METHODS: This model was induced in castrated male pigs (30 ± 2 kg; n = 21) by injecting thrombi (10-15 ml) via the left external jugular vein...
July 5, 2016: Chinese Medical Journal
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