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Castelman disease

Ricarda Riepl, Thomas Karl Hoffmann, Jens Greve
Castleman's disease is a very rare and potentially severe lymphoproliferative disorder. First sign may be cervical lymphadenitis, requiring sufficient support in diagnosis and therapy by an ENT specialist. Based on a case series the current manuscript gives an overview of the symptoms, the course of disease and the therapy options. Patients with the first diagnosis of a Castleman's disease at the ENT clinic of Ulm University during the years 2011-2015 were included. The duration of symptoms, the applied diagnostic and therapeutic algorithms were evaluated...
August 2017: Laryngo- Rhino- Otologie
Haidai Hu, Jiazhen Dong, Deguang Liang, Zengqiang Gao, Lei Bai, Rui Sun, Hao Hu, Heng Zhang, Yuhui Dong, Ke Lan
UNLABELLED: The oncogenic herpesvirus Kaposi's sarcoma-associated herpesvirus (KSHV) is known to encode four viral interferon regulatory factors (vIRF1 to -4) to subvert the host antiviral immune response, but their detailed DNA-binding profiles as transcription factors in the host remain uncharacterized. Here, we first performed genome-wide vIRF2-binding site mapping in the human genome using chromatin immunoprecipitation coupled with high-throughput sequencing (ChIP-seq). vIRF2 was capable of binding to the promoter regions of 100 putative target genes...
February 1, 2016: Journal of Virology
Dastan Temirbekov, Zahide Mine Yazici, Rabia Ergelen, Hurriyet Turgut, Fatma Tulin Kayhan
Castleman disease (CD) is a benign lymphoepithelial disorder characterised by abnormal growth of a lymph node. This disease may be seen anywhere along the lymphatic chain but it usually occurs in the mediastinum. Two clinical types (localised and generalised) and three histopathological types (hyaline vascular, plasma cell, and mixed) have been described. We present a case of a 35-year-old female patient with parotid CD of the hyaline-vascular type as an extremely rare entity. We also discuss recent updates on this disease...
July 2014: Otolaryngologia Polska
Hind M Alkatan, Ahmad Alaraj, Albarah El-Khani, Osama Al-Sheikh
PURPOSE: To study the pattern of ocular adnexal lymphoproliferative disorders (OALD) in an ophthalmic referral center in Saudi Arabia and to review their, histopathological characteristics with clinical correlation. METHODS: Retrospective chart review of 40 cases of patients who underwent incisional biopsy with the suspected diagnosis of periocular and/or adnexal lymphoid lesions over the period: 2000-2012 at the King Khaled Eye Specialist Hospital (KKESH), Riyadh, Saudi Arabia...
July 2013: Saudi Journal of Ophthalmology: Official Journal of the Saudi Ophthalmological Society
Aurélie Jeanne Tormo, Yasmine Meliani, Linda Ann Beaupré, Mukut Sharma, Jörg H Fritz, Greg Elson, Sandrine Crabé, Jean-François Gauchat
IL-27 is an APC-derived IL-6/IL-12 family composite cytokine with multiple functions such as regulation of Th1, Th17, and regulatory T cell differentiation, B cell proliferation, and Ig class switching. The IL-27 complex is formed by the association of the cytokine p28 with the soluble cytokine receptor EBV-induced gene 3 (EBI3). The IL-27 cytokine and soluble receptor subunits p28 and EBI3 can be secreted independently. The p28 subunit has been shown to have IL-27-independent biological activities. We previously demonstrated that p28 can form an alternative composite cytokine with the EBI3 homolog cytokine-like factor 1 (CLF; CRLF1)...
August 15, 2013: Journal of Immunology: Official Journal of the American Association of Immunologists
Anke Schultz, Sieghart Sopper, Ulrike Sauermann, Andreas Meyerhans, Rodolphe Suspène
BACKGROUND: Recombination is an important mechanism in the generation of genetic diversity of the human (HIV) and simian (SIV) immunodeficiency viruses. It requires the co-packaging of divergent RNA genomes into the same retroviral capsid and subsequent template switching during the reverse transcription reaction. By HIV-specific fluorescence in situ hybridization (FISH), we have previously shown that the splenocytes from 2 chronically infected patients with Castelman's disease were multi-infected and thus fulfill the in vivo requirements to generate genetic diversity by recombination...
2012: Retrovirology
Nadia Talat, Ajay P Belgaumkar, Klaus-Martin Schulte
OBJECTIVES: We undertook a systematic review of 404 published cases of Castleman's disease to identify the role of the surgeon beyond assistance in tissue-based diagnosis. BACKGROUND: Castleman's disease is a rare primary disease of the lymph node caused by infection with herpesviridae. Little is known about the role of surgery in this condition. DATA SOURCES: Medline, Embase, Cochrane Database of Systematic Reviews, ISI Thompson Web of Knowledge, and hand search of articles' bibliography...
April 2012: Annals of Surgery
Ruxandra Ulmeanu, A Râjnoveanu, Eugenia Halic, D Popa, Anca Macri, F Mihălţan
The first case of endobronchial sarcoidosis was described by Benedict and Castelman in 1941. The endoscopic aspects in sarcoidosis can reveal: erythema, edema, network of capillary ectases, granularity, irregular mucosa thickening, macro and micro nodules in mucosa, bronchial and tracheal stenosis, distortions, tractions (including at the large and medium airways), sometimes bronchial ectases secondary to these modifications. The doctors must be aware of the possibility of affecting the great airways in sarcoidosis, such situation, although rare, could make for a difficult diagnosis, especially in the case of the tusigen syndrome or persistent and unexplained wheezing...
July 2011: Pneumologia: Revista Societății Române de Pneumologie
S Sarno, E Papinutto, C Franchin, J Bain, M Elliott, F Meggio, Z Kazimierczuk, A Orzeszko, G Zanotti, R Battistutta, L A Pinna
CK2 denotes a pleiotropic, constitutively active protein kinase whose abnormally high level in many cancer cells is held as an example of "non oncogene addiction". A wide spectrum of cell permeable, fairly specific ATP site-directed CK2 inhibitors are currently available which are proving useful to dissect its biological functions and which share the property of inducing apoptosis of cancer cells with no comparable effect on their "normal" counterparts. One of these, CX-4945, has recently entered clinical trials for the treatment of advanced solid tumors, Castelman's disease and multiple myeloma...
2011: Current Topics in Medicinal Chemistry
A B Cervini, V Tosi, S H Kim, M Bocian, G Chantada, C Nousari, O G Carballo, A M Pierini
Paraneoplastic pemphigus is an autoimmune blistering disease associated with an occult or previously diagnosed tumor. Its clinical, histological, and immunological features have been clearly defined. It is characterized by the presence of polymorphic skin lesions and by erosions of the oral and genital mucosas that are refractory to conventional treatments. The histology can be variable and includes acantholysis or lichenoid dermatitis. Circulating autoantibodies are a constant feature and confirm the diagnosis...
December 2010: Actas Dermo-sifiliográficas
Y Sekkach, H Baizri, J Mounach, H Qacif, N El Omri, H Chahdi, F Rkiouak, G Belmejdoub, D Ghafir, V Ohayon, J-P Algayres
We report a historical case of hyperparathyroidism in a young patient hospitalized for an array of osteolytic foci and incomplete fracture associated with a swollen neck, revealing a very special form of a metastatic parathyroid carcinoma with unusual multiple locations and exceptional medullary flooding. Carcinoma of the parathyroid gland produces a malignant hypersecreting tumor particularly difficult to diagnose. Treatment of this rare tumor is primarily surgical. The preoperative syndrome is unusually severe primary hyperparathyroidism...
March 2009: Annales D'endocrinologie
Grzegorz Sarek, Päivi M Ojala
KSHV infection is the causative agent in three different tumor types: Kaposi's sarcoma, a plasmablastic variant of multicentric Castelman's disease and an AIDS-related form of B cell lymphoproliferative disorder called primary effusion lymphoma (PEL). PEL manifests as an effusion malignancy in Kaposi's sarcoma patients with advanced AIDS, but also occurs in HIV-negative individuals. PEL is a very aggressive disease, and currently there are no efficient therapies for treating PEL. In our recent paper we report that p53 reactivation by a small molecule inhibitor of p53-MDM2 interaction, Nutlin-3a, induces selective and massive apoptosis in PEL cells, and has striking anti-tumor activity in a mouse xenograft PEL model...
September 15, 2007: Cell Cycle
Maha Driss, Dhouha Bacha, Karima Mrad, Rym Dhouib, Samia Sassi, Imen Abbes, Ali Chebbi, Khaled Ben Romdhane
Inflammatory liposarcoma represents a rare variant of well-differentiated liposarcoma in which a chronic inflammatory infiltrate predominates simulating the appearance of malignant lymphoma and other nonneoplastic lesions. A case of this lesion occurring in the retroperitoneum was described in 43-year-old man. The differential diagnosis, especially from lymphoma and non neoplastic lesions such as inflammatory myofibroblastic tumor and Castelman disease are discussed.
February 2007: Annales de Pathologie
Jean Bréaud, Ioana Oborocianu, Ronny Bensaïd, Marie-Christine Saint-Paul, Anne Chevallier, Patrick Chevallier, Jean Gugenheim, Jean-Yves Kurzenne
No abstract text is available yet for this article.
November 2006: Gastroentérologie Clinique et Biologique
E Radzikowska, J Pawlowski, M Chabowski, R Langfort
A 37-year-old woman with hialin- vascular type Castelman's disease (CD) localised in the retroperitoneal region, incompletely resected, developed progressive dyspnoea. The chest radiograph taken 3 months before the operation was normal. The chest CT scan revealed diffused bronchiectases, hyperinflation and air trapping. Pulmonary function tests disclosed severe obstructive impairment with hyperinflation. The bronchoscopic examination of the bronchial tree was normal. Cultures of sputum, bronchial washing and blood were negative...
December 2005: Monaldi Archives for Chest Disease, Archivio Monaldi Per le Malattie del Torace
Mauro S Malnati, Lorenzo Dagna, Maurilio Ponzoni, Paolo Lusso
Human herpesvirus 8 (HHV-8), also defined Kaposi's sarcoma (KS)-associated herpesvirus, was identified by Chang and colleagues in 1994 using purely molecular techniques, before any serological evidence or virus isolation in cell culture could be achieved. HHV-8 is unique among herpesviruses because its prevalence in the general population is low and because it possesses the richest weaponry of viral oncogenes and tumor-promoting factors ever described. Eleven HHV-8-specific genes are homologs of cellular genes, which were hijacked from the host during a long parallel evolution, and at least five of such genes show both in vitro and in vivo transforming ability...
December 2003: Reviews in Clinical and Experimental Hematology
B Abboud, E Jabbour, G Chahine
Castelman's disease, an unusual condition of unknown cause, consisting of a massive proliferation of lymphoid tissue. Three histologic variants (hyaline vascular, plasma-cell, and mixed) and two clinical types (localized and multicentric) of Castelman's disease have been described. Localized disease can be cured with surgery or radiotherapy, but complete remission in patients with multicentric disease have been achieved only with prednisone or chemotherapy given at the time of diagnosis. The aim of this study is to report two cases of retroperitoneal Castelman's disease with review of the literature...
November 2001: Le Journal Médical Libanais. the Lebanese Medical Journal
R Palmeri, S Gorgone, S Lazzara, G Melita
Castelman disease is a rare disease of lymph nodes. There are 2 pathological types: hyalo-vascular asymptomatic form and plasmacytic symptomatic form. Authors report a case of Castelman disease of a subclavicular lymph nodes that underwent surgical operation. Ethiopathogenesis and treatment of the disease are reported.
1997: Chirurgia Italiana
Fabiola Micheletti, Paolo Monini, Cinzia Fortini, Paola Rimessi, Martina Bazzaro, Massimo Andreoni, Massimo Giuliani, Serena Traniello, Barbara Ensoli, Riccardo Gavioli
The human herpesvirus 8 (HHV-8) is a human gamma2-herpesvirus that is implicated in the development of Kaposi's sarcoma (KS), primary effusion lymphoma and Castelman's disease. Since the responses of cytotoxic T lymphocytes (CTL) play a key role in the control of herpesvirus infection, it is important to identify and to characterize the CTL target epitopes of HHV-8 viral antigens. In this study, using peptide-binding motifs, we selected potential human leucocyte antigen (HLA)-A2-binding peptides from kaposin A and glycoprotein H (gH), that are latent and lytic HHV-8 antigens, respectively...
July 2002: Immunology
P Fraticelli, M Sironi, G Bianchi, D D'Ambrosio, C Albanesi, A Stoppacciaro, M Chieppa, P Allavena, L Ruco, G Girolomoni, F Sinigaglia, A Vecchi, A Mantovani
Fractalkine (FKN, CX3CL1) is a membrane-bound CX3C chemokine induced by primary proinflammatory signals in vascular endothelial cells (ECs). Here we examined the role of FKN in polarized Th1 or Th2 responses. Proinflammatory signals, including LPS, IL-1, TNF, and CD40 ligand, induced FKN, as did IFN-gamma, which had synergistic activity with TNF. IL-4 and IL-13 did not stimulate the expression of FKN and markedly reduced induction by TNF and IFN-gamma. TNF alone or combined with IFN-gamma also induced release of soluble FKN, which was inhibited by IL-4 and IL-13...
May 2001: Journal of Clinical Investigation
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