keyword
https://read.qxmd.com/read/38427243/quantitative-investigation-of-neuroprotective-role-of-ror1-in-a-cell-culture-model-of-alzheimer-s-disease
#21
JOURNAL ARTICLE
Kaushik Chanda, Debashis Mukhopadhyay
Cytoskeletal and microtubule atrophy are major hallmarks of Alzheimer's disease (AD). A method to investigate endogenous proteins that can interact/stabilize the cytoskeleton (under pathological cues) is rare. Here, we describe how receptor tyrosine kinase-like orphan receptor 1 (ROR1), a receptor tyrosine kinase (RTK), can act as a neuroprotective molecule by promoting neurite outgrowth, stabilizing cytoskeletal components, and altering the dynamics of actin assembly in a cell culture model of AD.
2024: Methods in Molecular Biology
https://read.qxmd.com/read/38423163/the-interaction-between-adk-and-scg10-regulate-the-repair-of-nerve-damage
#22
JOURNAL ARTICLE
Tianjun Chen, Zhiwan Chen, Ping Wu, Jianxian Luo, Qiuling Liu, Hua Yang, Cheng Peng, Guowei Zhang, Hongsheng Lin, Zhisheng Ji
The cytoskeleton must be remodeled during neurite outgrowth, and Superior Cervical Ganglion 10 (SCG10) plays a critical role in this process by depolymerizing Microtubules (MTs), conferring highly dynamic properties to the MTs. However, the precise mechanism of action of SCG10 in the repair of injured neurons remains largely uncertain. Using transcriptomic identification, we discovered that SCG10 expression was downregulated in neurons after Spinal Cord Injury (SCI). Additionally, through mass spectrometry identification, immunoprecipitation, and pull-down assays, we established that SCG10 could interact with Adenosine Kinase (ADK)...
February 27, 2024: Neuroscience
https://read.qxmd.com/read/38415376/multiomics-evaluation-of-human-ipscs-and-ipsc-derived-neurons
#23
JOURNAL ARTICLE
Gwang Bin Lee, Wan Nur Atiqah Binti Mazli, Ling Hao
Human induced pluripotent stem cells (iPSCs) can be differentiated into neurons, providing living human neurons to model brain diseases. However, it is unclear how different types of molecules work together to regulate stem cell and neuron biology in healthy and disease states. In this study, we conducted integrated proteomics, lipidomics, and metabolomics analyses with confident identification, accurate quantification, and reproducible measurements to compare the molecular profiles of human iPSCs and iPSC-derived neurons...
February 28, 2024: Journal of Proteome Research
https://read.qxmd.com/read/38412382/advanced-hollow-cathode-discharge-plasma-treatment-of-unique-bilayered-fibrous-nerve-guidance-conduits-for-enhanced-oriented-neurite-outgrowth
#24
JOURNAL ARTICLE
Sheida Aliakbarshirazi, Rouba Ghobeira, Mahtab Asadian, Mehrnoush Narimisa, Anton Nikiforov, Ives De Baere, Wim Van Paepegem, Nathalie De Geyter, Heidi Declercq, Rino Morent
Despite all recent progresses in nerve tissue engineering, critical-sized nerve defects are still extremely challenging to repair. Therefore, this study targets the bridging of critical nerve defects and promoting an oriented neuronal outgrowth by engineering innovative nerve guidance conduits (NGCs) synergistically possessing exclusive topographical, chemical, and mechanical cues. To do so, a mechanically adequate mixture of polycaprolactone (PCL) and polylactic- co -glycolic acid (PLGA) was first carefully selected as base material to electrospin nanofibrous NGCs simulating the extracellular matrix...
February 27, 2024: Biomacromolecules
https://read.qxmd.com/read/38401360/hybrid-pharmacophore-design-and-synthesis-of-donepezil-inspired-aurone-derivative-salts-as-multifunctional-acetylcholinesterase-inhibitors
#25
JOURNAL ARTICLE
Rei Funahashi, Fumiaki Matsuura, Masayuki Ninomiya, Sayo Okabe, Shigeo Takashima, Kaori Tanaka, Atsuyoshi Nishina, Mamoru Koketsu
Flavonoids, a ubiquitous group of plant polyphenols, are well-known for their beneficial effects on human health. Their phenylchromane skeletons have structural similarities to donepezil [the US FDA-approved drug used to treat Alzheimer's disease (AD)]. The objective of this study was to design and synthesize valuable agents derived from flavonoids for relieving the symptoms of AD. A variety of flavonoid derivative salts incorporating benzylpyridinium units were synthesized and several of them remarkedly inhibited acetylcholinesterase (AChE) activity in vitro...
February 20, 2024: Bioorganic Chemistry
https://read.qxmd.com/read/38400573/advancements-in-the-study-of-synaptic-plasticity-and-mitochondrial-autophagy-relationship
#26
REVIEW
Yousong Zhu, Qinlong Hui, Zheng Zhang, Hao Fu, Yali Qin, Qiong Zhao, Qinqing Li, Junlong Zhang, Lei Guo, Wenbin He, Cheng Han
Synapses serve as the points of communication between neurons, consisting primarily of three components: the presynaptic membrane, synaptic cleft, and postsynaptic membrane. They transmit signals through the release and reception of neurotransmitters. Synaptic plasticity, the ability of synapses to undergo structural and functional changes, is influenced by proteins such as growth-associated proteins, synaptic vesicle proteins, postsynaptic density proteins, and neurotrophic growth factors. Furthermore, maintaining synaptic plasticity consumes more than half of the brain's energy, with a significant portion of this energy originating from ATP generated through mitochondrial energy metabolism...
February 2024: Journal of Neuroscience Research
https://read.qxmd.com/read/38393165/effect-of-acrylamide-and-mycotoxins-in-sh-sy5y-cells-a-review
#27
REVIEW
Luna Bridgeman, Cristina Juan, Houda Berrada, Ana Juan-García
Thermal processes induce the formation of undesired toxic components, such as acrylamide (AA), which has been shown to induce brain toxicity in humans and classified as Group 2A by the International Agency of Research in Cancer (IARC), as well as some mycotoxins. AA and mycotoxins' toxicity is studied in several in vitro models, including the neuroblastoma cell line model SH-SY5Y cells. Both AA and mycotoxins occur together in the same food matrix cereal base (bread, pasta, potatoes, coffee roasting, etc.)...
February 6, 2024: Toxins
https://read.qxmd.com/read/38390494/modeling-the-precise-interaction-of-glioblastoma-with-human-brain-region-specific-organoids
#28
JOURNAL ARTICLE
Qi Fan, Hanze Wang, Tianyi Gu, Huihui Liu, Peng Deng, Bo Li, Hui Yang, Ying Mao, Zhicheng Shao
Glioblastoma is a highly aggressive malignant tumor of the central nervous system, but the interaction between glioblastoma and different types of neurons remains unclear. Here, we established a co-culture model in vitro using 3D printed molds with microchannels, in which glioblastoma organoids (GB), dorsal forebrain organoids (DO, mainly composed of excitatory neurons), and ventral forebrain organoids (VO, mainly composed of inhibitory neurons) were assembled. Our results indicate that DO has a greater impact on altered gene expression profiles of GB, resulting in increased invasive potential...
March 15, 2024: IScience
https://read.qxmd.com/read/38387714/modulation-of-neuronal-morphology-by-antipsychotic-drug-involvement-of-serotonin-receptor-7
#29
JOURNAL ARTICLE
Luisa Speranza, Marta Molinari, Floriana Volpicelli, Enza Lacivita, Marcello Leopoldo, Salvatore Pulcrano, Gian Carlo Bellenchi, Carla Perrone Capano, Marianna Crispino
Antipsychotic drugs (APDs) are the primary pharmacological treatment for schizophrenia, a complex disorder characterized by altered neuronal connectivity. Atypical or second-generation antipsychotics, such as Risperidone (RSP) and Clozapine (CZP) predominantly block dopaminergic D2 and serotonin receptor 2A (5-HT2A) neurotransmission. Both compounds also exhibit affinity for the 5-HT7R, with RSP acting as an antagonist and CZP as an inverse agonist. Our study aimed to determine whether RSP and CZP can influence neuronal morphology through a 5-HT7R-mediated mechanism...
February 20, 2024: Brain Research
https://read.qxmd.com/read/38387692/re-exploration-of-tetrahydro-%C3%AE-carboline-scaffold-discovery-of-selective-histone-deacetylase-6-inhibitors-with-neurite-outgrowth-promoting-and-neuroprotective-activities
#30
JOURNAL ARTICLE
Wen Wen, Jiadong Hu, Chenxi Wang, Rui Yang, Yabo Zhang, Baibei Huang, Tingting Qiao, Jiayun Wang, Xin Chen
Histone deacetylase 6 (HDAC6) has drawn more and more attention for its potential application in Alzheimer's disease (AD) therapy. A series of tetrahydro-β-carboline (THβC) hydroxamic acids with aryl linker were synthesized. In enzymatic assay, all compounds exhibited nanomolar IC50 values. The most promising compound 11d preferentially inhibited HDAC6 (IC50 , 8.64 nM) with approximately 149-fold selectivity over HDAC1. Molecular simulation revealed that the hydroxamic acid of 11d could bind to the zinc ion by a bidentate chelating manner...
February 20, 2024: Bioorganic & Medicinal Chemistry Letters
https://read.qxmd.com/read/38367864/differentiated-mesenchymal-stem-cells-derived-exosomes-immobilized-in-decellularized-sciatic-nerve-hydrogels-for-peripheral-nerve-repair
#31
JOURNAL ARTICLE
Bo Liu, Olawale A Alimi, Yanfei Wang, Yunfan Kong, Mitchell Kuss, Mena Krishnan, Guoku Hu, Yi Xiao, Jixin Dong, Dominick J DiMaio, Bin Duan
Peripheral nerve injury (PNI) and the limitations of current treatments often result in incomplete sensory and motor function recovery, which significantly impact the patient's quality of life. While exosomes (Exo) derived from stem cells and Schwann cells have shown promise on promoting PNI repair following systemic administration or intraneural injection, achieving effective local and sustained Exo delivery holds promise to treat local PNI and remains challenging. In this study, we developed Exo-loaded decellularized porcine nerve hydrogels (DNH) for PNI repair...
February 15, 2024: Journal of Controlled Release
https://read.qxmd.com/read/38364446/in-vitro-neuronal-and-glial-response-to-magnetically-stimulated-piezoelectric-poly-hydroxybutyrate-co-hydroxyvalerate-phbv-cobalt-ferrite-cfo-microspheres
#32
JOURNAL ARTICLE
Tiffany S Pinho, Jorge Ribeiro Cibrão, Deolinda Silva, Sandra Barata-Antunes, Jonas Campos, João L Afonso, Belém Sampaio-Marques, Clarisse Ribeiro, André S Macedo, Pedro Martins, Cristiana B Cunha, Senentxu Lanceros-Mendez, António J Salgado
Polymer biomaterials are being considered for tissue regeneration due to the possibility of resembling different extracellular matrix characteristics. However, most current scaffolds cannot respond to physical-chemical modifications of the cell microenvironment. Stimuli-responsive materials, such as electroactive smart polymers, are increasingly gaining attention once they can produce electrical potentials without external power supplies. The presence of piezoelectricity in human tissues like cartilage and bone highlights the importance of electrical stimulation in physiological conditions...
February 10, 2024: Biomater Adv
https://read.qxmd.com/read/38362695/zuogui-pill-promotes-neurite-outgrowth-by-regulating-opn-igf-1r-pten-and-downstream-mtor-signaling-pathway
#33
JOURNAL ARTICLE
Yan Liu, Dan Wu, Xiaohui Yan, Xinyu Xu, Jian Zhu, Changyin Li, Qinghua Feng, Li Li, Minghua Wu, Wenlei Li
AIM AND OBJECTIVE: Zuogui pill (ZGP) is the traditional Chinese medicine for tonifying kidney yin. Clinical and animal studies have shown that ZGP effectively enhances neurologic impairment after ischemic stroke, which may be related to promoting neurite outgrowth. This investigation aimed to prove the pro-neurite outgrowth impact of ZGP and define the underlying molecular pathway in vitro. MATERIALS AND METHODS: The major biochemical components in the ZGP were investigated using UPLC-QTOF-MS...
February 15, 2024: Combinatorial Chemistry & High Throughput Screening
https://read.qxmd.com/read/38361127/tau-depletion-in-human-neurons-mitigates-a%C3%AE-driven-toxicity
#34
JOURNAL ARTICLE
Bryan Ng, Jane Vowles, Féodora Bertherat, Ajantha Abey, Peter Kilfeather, Dayne Beccano-Kelly, M Irina Stefana, Darragh P O'Brien, Nora Bengoa-Vergniory, Phillippa J Carling, John A Todd, Tara M Caffrey, Natalie Connor-Robson, Sally A Cowley, Richard Wade-Martins
Alzheimer's disease (AD) is an age-related neurodegenerative condition and the most common type of dementia, characterised by pathological accumulation of extracellular plaques and intracellular neurofibrillary tangles that mainly consist of amyloid-β (Aβ) and hyperphosphorylated tau aggregates, respectively. Previous studies in mouse models with a targeted knock-out of the microtubule-associated protein tau (Mapt) gene demonstrated that Aβ-driven toxicity is tau-dependent. However, human cellular models with chronic tau lowering remain unexplored...
February 15, 2024: Molecular Psychiatry
https://read.qxmd.com/read/38357957/toxic-advanced-glycation-end-product-dependent-alzheimer-s-disease-like-alternation-in-the-microtubule-system
#35
JOURNAL ARTICLE
Hayahide Ooi, Yoshiki Koriyama
Type 2 diabetes mellitus (T2DM) is a risk factor for Alzheimer's Disease (AD). However, the detailed mechanism underlying T2DM-related AD remains unknown. In DM, many types of advanced glycation end products (AGEs) are formed and accumulated. In our previous study, we demonstrated that Glyceraldehyde (GA)-derived toxic Advanced Glycation End products (toxic AGEs, TAGE) strongly showed cytotoxicity against neurons and induced similar alterations to those observed in AD. Further, GA induced dysfunctional neurite outgrowth via TAGE-β-tubulin aggregation, which resulted in the TAGE-dependent abnormal aggregation of β-tubulin and tau phosphorylation...
February 14, 2024: Current Alzheimer Research
https://read.qxmd.com/read/38356706/identification-of-cdkn3-as-a-key-gene-that-regulates-neuroblastoma-cell-differentiation
#36
JOURNAL ARTICLE
Alexandra Vernaza, Daniela F Cardus, Jadyn L Smith, Veronica Partridge, Amy L Baker, Emma G Lewis, Angela Zhang, Zhenze Zhao, Liqin Du
We conducted a high-content screening (HCS) in neuroblastoma BE(2)-C cells to identify cell cycle regulators that control cell differentiation using a library of siRNAs against cell cycle-regulatory genes. We discovered that knocking down expression of cyclin dependent kinase inhibitor 3 (CDKN3) showed the most potent effect in inducing neurite outgrowth, the morphological cell differentiation marker of neuroblastoma cells. We then demonstrated that CDKN3 knockdown increased expression of neuroblastoma molecular differentiation markers, neuron specific enolase (NSE), βIII-tubulin and growth associated protein 43 (GAP43)...
2024: Journal of Cancer
https://read.qxmd.com/read/38340248/neurotrophic-natural-products
#37
JOURNAL ARTICLE
Yoshiyasu Fukuyama, Miwa Kubo, Kenichi Harada
Neurotrophins (NGF, BDNF, NT3, NT4) can decrease cell death, induce differentiation, as well as sustain the structure and function of neurons, which make them promising therapeutic agents for the treatment of neurodegenerative disorders. However, neurotrophins have not been very effective in clinical trials mostly because they cannot pass through the blood-brain barrier owing to being high-molecular-weight proteins. Thus, neurotrophin-mimic small molecules, which stimulate the synthesis of endogenous neurotrophins or enhance neurotrophic actions, may serve as promising alternatives to neurotrophins...
2024: Progress in the Chemistry of Organic Natural Products
https://read.qxmd.com/read/38336024/overexpression-of-forebrain-ptp1b-leads-to-synaptic-and-cognitive-impairments-in-obesity
#38
JOURNAL ARTICLE
Xing Ge, Minmin Hu, Menglu Zhou, Xiaoli Fang, Xi Chen, Deqin Geng, Li Wang, Xiaoying Yang, Huimei An, Meng Zhang, Danhong Lin, Mingxuan Zheng, Xiaoying Cui, Qing Wang, Yuqing Wu, Kuiyang Zheng, Xu-Feng Huang, Yinghua Yu
Obesity has reached pandemic proportions and is a risk factor for neurodegenerative diseases, including Alzheimer's disease. Chronic inflammation is common in obese patients, but the mechanism between inflammation and cognitive impairment in obesity remains unclear. Accumulative evidence shows that protein-tyrosine phosphatase 1B (PTP1B), a neuroinflammatory and negative synaptic regulator, is involved in the pathogenesis of neurodegenerative processes. We investigated the causal role of PTP1B in obesity-induced cognitive impairment and the beneficial effect of PTP1B inhibitors in counteracting impairments of cognition, neural morphology, and signaling...
February 7, 2024: Brain, Behavior, and Immunity
https://read.qxmd.com/read/38331016/lysyl-oxidase-like-1-deficiency-in-optic-nerve-head-astrocytes-elicits-reactive-astrocytosis-and-alters-functional-effects-of-astrocyte-derived-exosomes
#39
JOURNAL ARTICLE
Harsh N Hariani, Anita K Ghosh, Sasha M Rosen, Huen-Yee Tso, Cassidy Kessinger, Chongyu Zhang, W Keith Jones, Rebecca M Sappington, Claire H Mitchell, Evan B Stubbs, Vidhya R Rao, Simon Kaja
Glaucoma is a multifactorial progressive ocular pathology that manifests clinically with damage to the optic nerve (ON) and the retina, ultimately leading to blindness. The optic nerve head (ONH) shows the earliest signs of glaucoma pathology, and therefore, is an attractive target for drug discovery. The goal of this study was to elucidate the effects of reactive astrocytosis on the elastin metabolism pathway in primary rat optic nerve head astrocytes (ONHA), the primary glial cell type in the unmyelinated ONH...
February 6, 2024: Experimental Eye Research
https://read.qxmd.com/read/38320719/investigating-the-therapeutic-effects-of-novel-compounds-targeting-inflammatory-il-1%C3%AE-and-il-6-signaling-pathways-in-spinocerebellar-ataxia-type-3
#40
JOURNAL ARTICLE
I-Cheng Chen, Wan-Ling Chen, Kuo-Hsuan Chang, Jun-Wei Lee, Te-Hsien Lin, Wenwei Lin, Chiung-Mei Chen, Guey-Jen Lee-Chen
At least seven dominantly inherited spinocerebellar ataxias (SCA) are caused by expansions of polyglutamine (polyQ)-encoding CAG repeat. The misfolded and aggregated polyQ-expanded proteins increase reactive oxygen species (ROS), cellular toxicity, and neuroinflammation in the disease pathogenesis. In this study, we evaluated the anti-inflammatory potentials of coumarin derivatives LM-021, LMDS-1, LMDS-2, and pharmacological chaperone tafamidis using mouse BV-2 microglia and SCA3 ataxin-3 (ATXN3)/Q75 -GFP SH-SY5Y cells...
February 4, 2024: European Journal of Pharmacology
keyword
keyword
62434
2
3
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read
×

Save your favorite articles in one place with a free QxMD account.

×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"

We want to hear from doctors like you!

Take a second to answer a survey question.