Xing Ge, Minmin Hu, Menglu Zhou, Xiaoli Fang, Xi Chen, Deqin Geng, Li Wang, Xiaoying Yang, Huimei An, Meng Zhang, Danhong Lin, Mingxuan Zheng, Xiaoying Cui, Qing Wang, Yuqing Wu, Kuiyang Zheng, Xu-Feng Huang, Yinghua Yu
Obesity has reached pandemic proportions and is a risk factor for neurodegenerative diseases, including Alzheimer's disease. Chronic inflammation is common in obese patients, but the mechanism between inflammation and cognitive impairment in obesity remains unclear. Accumulative evidence shows that protein-tyrosine phosphatase 1B (PTP1B), a neuroinflammatory and negative synaptic regulator, is involved in the pathogenesis of neurodegenerative processes. We investigated the causal role of PTP1B in obesity-induced cognitive impairment and the beneficial effect of PTP1B inhibitors in counteracting impairments of cognition, neural morphology, and signaling...
February 7, 2024: Brain, Behavior, and Immunity