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https://www.readbyqxmd.com/read/28922825/catholic-understandings-of-female-sexuality-in-1960s-britain
#1
David Geiringer
Recent interpretations of religious change in modern Britain have stressed the importance of a sudden and abrupt 'sexual revolution' during the 1960s. The role the Churches played in bringing about their own demise remains a point of debate, particularly in the case of the Catholic Church. This article attempts to move beyond existing historical disputes over a 'religious crisis' and whether it was rooted in 'internal' causes (problems within the Church) or 'external', secular developments. It explores the way sexual knowledge was discussed and disseminated by Catholic authorities during this decade of perceived cultural transition, drawing on the previously unpublished papers of the Papal Commission for Birth Control 1963-5 and the training manuals of the Catholic Marriage Advisory Council (CMAC)...
June 1, 2017: 20 Century British History
https://www.readbyqxmd.com/read/28922738/mixed-symptoms-in-major-depressive-and-bipolar-disorders-a-systematic-review
#2
REVIEW
Gustavo H Vázquez, María Lolich, Casimiro Cabrera, Ruzica Jokic, Dusan Kolar, Leonardo Tondo, Ross J Baldessarini
BACKGROUND: The DSM-5 mixed features specifier for mood disorders encourages renewed interest in mixed states and led us to pool research findings regarding prevalence of mixed features in episodes of major depressive (MDD) and bipolar disorders (BD). METHODS: We systematically searched to July 2017 for reports on mixed symptoms in depressive episodes of MDD and in depression and mania or hypomania in types I and II BD. For primary mood-states and diagnostic groups we compared rates of the presence of mixed symptoms: as defined by DSM-5 (≥3 features opposite to the dominant mood-polarity but not overlapping those of the primary disorder) or as having any ≥3 features of opposite polarity...
September 8, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28922584/characterization-and-pro-inflammatory-responses-of-spore-and-hyphae-samples-from-various-mold-species
#3
E Øya, Akj Afanou, N Malla, S Uhlig, E Rolen, I Skaar, A Straumfors, J O Winberg, B E Bang, P E Schwarze, W Eduard, J A Holme
Mold particles from Aspergillus fumigatus, Penicillium chrysogenum, Aspergillus versicolor and Stachybotrys chartarum have been linked to respiratory-related diseases. Here we characterized X-ray-inactivated spores and hyphae fragments from these species by number of particles, morphology, and mycotoxin, β-glucan and protease content/activity. The pro-inflammatory properties of mold particles were examined in human bronchial epithelial cells (BEAS-2B) and THP-1 monocytes and phorbol 12-myristate 13-acetate (PMA)-differentiated THP-1...
September 18, 2017: Indoor Air
https://www.readbyqxmd.com/read/28922141/towards-an-in-plane-methodology-to-track-breast-lesions-by-using-mammograms-and-patient-specific-finite-element-simulations
#4
Andres Lapuebla-Ferri, Jose Cegoñino-Banzo, Antonio-Jose Jimenez-Mocholi, Amaya Perez Del Palomar
In breast cancer screening or diagnosis, it is usual to combine different images in order to locate a lesion as accurately as possible. These images are generated by using a single or several imaging techniques. As X-ray based mammography is used widespread, a breast lesion is located in the same plane of the image (mammogram), but tracking of a breast lesion across mammograms corresponding to different views is a daring task for medical physicians. According to this, simulation tools and methodologies that use patient-specific numerical models can facilitate the task of fusing information from different images...
September 18, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/28921949/effects-of-high-temperature-and-thermal-cycling-on-the-performance-of-perovskite-solar-cells-acceleration-of-charge-recombination-and-deterioration-of-charge-extraction
#5
Arif D Sheikh, Rahim Munir, Md Azimul Haque, Ashok Bera, Weijin Hu, Parvez Shaikh, Aram Amassian, Tom Wu
In this work, we investigated the effects of high operating temperature and thermal cycling on the photovoltaic performance of perovskite solar cells (PSCs) with a typical mesostructured (m)-TiO2-CH3NH3PbI3-xClx-spiro-OMeTAD architecture. After carrying out temperature-dependent grazing incidence wide-angle X-ray scattering (GIWAXS), in-situ X-ray diffraction (XRD) and optical absorption experiments, thermal durability of PSCs was tested by subjecting the devices to repetitive heating to 70 °C and cooling to room temperature (20 °C)...
September 18, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28921934/mirror-trends-of-plasticity-and-stability-indicators-in-primate-prefrontal-cortex
#6
Miguel Á García-Cabezas, Mary Kate P Joyce, Yohan J John, Basilis Zikopoulos, Helen Barbas
Research on plasticity markers in the cerebral cortex has largely focused on their timing of expression and role in shaping circuits during critical and normal periods. By contrast, little attention has been focused on the spatial dimension of plasticity-stability across cortical areas. The rationale for this analysis is based on the systematic variation in cortical structure that parallels functional specialization and raises the possibility of varying levels of plasticity. Here we investigated in adult rhesus monkeys the expression of markers related to synaptic plasticity or stability in prefrontal limbic and eulaminate areas that vary in laminar structure...
September 16, 2017: European Journal of Neuroscience
https://www.readbyqxmd.com/read/28921866/autophagy-and-cancer-insights-from-mouse-models
#7
REVIEW
Laura Mainz, Mathias T Rosenfeldt
(Macro-)autophagy is an evolutionary conserved "self-digestion program" that serves to maintain cellular metabolism and is implicated in many pathological processes such as cancer. In recent years, an increasing number of studies in murine cancer models have provided a plethora of sometimes conflicting results about the role of autophagy in cancer biology. This review summarises these studies and raises awareness that there are situations in which autophagy blockage might indeed reduce tumor growth, but that sometimes the exact opposite is the case...
September 16, 2017: FEBS Journal
https://www.readbyqxmd.com/read/28921770/does-an-observer-s-empathy-influence-my-pain-effect-of-perceived-empathetic-or-unempathetic-support-in-a-pain-test
#8
C Fauchon, I Faillenot, A M Perrin, C Borg, V Pichot, F Chouchou, L Garcia-Larrea, R Peyron
The physiological and behavioural effects of empathy for other's pain have been widely investigated, while the opposite situation, i.e. the influence on one's pain of empathetic feedback from others, remains largely unexplored. Here, we assessed whether and how empathetic and unempathetic comments from observers modulate pain and associated vegetative reactions. In Study 1, conversations between observers of a pain study were recorded by professional actors. Comments were prepared to be perceived as empathetic, unempathetic, or neutral, and were validated in 40 subjects...
September 16, 2017: European Journal of Neuroscience
https://www.readbyqxmd.com/read/28921745/transcription-factor-ccaat-enhancer-binding-protein-%C3%AE-upregulates-microrna-let-7f-1-in-human-endocervical-cells
#9
Kanchana Ayyar, Kudumula Venkata Rami Reddy
PROBLEM: In endocervical epithelial cells (End1/E6E7), miRNA let-7f plays an important role in the control of innate immunity. The underlying molecular mechanism for let-7f regulation in these cells remains largely unclear. METHODS OF STUDY: let-7f was knocked down in End1/E6E7 cells using siRNA, and differential gene expression was analyzed by microarray. Differentially expressed genes were validated by qPCR and Western blot. Expression of let-7f was studied by qPCR after inhibition of C/EBPβ with betulinic acid (BA) and pCMVβ plasmid and after overexpression of C/EBPβ with pCMVβ+ plasmid...
September 16, 2017: American Journal of Reproductive Immunology: AJRI
https://www.readbyqxmd.com/read/28921585/allergooncology-opposite-outcomes-of-immune-tolerance-in-allergy-and-cancer
#10
E Jensen-Jarolim, H J Bax, R Bianchini, S Crescioli, T R Daniels-Wells, D Dombrowicz, E Fiebiger, H J Gould, S Irshad, J Janda, D H Josephs, F Levi-Schaffer, L O Mahony, G Pellizzari, M L Penichet, F Redegeld, F Roth-Walter, J Singer, E Untersmayr, L Vangelista, S N Karagiannis
While desired for the cure of allergy, regulatory immune cell subsets and non-classical Th2-biased inflammatory mediators in the tumour microenvironment can contribute to immune suppression and escape of tumours from immunological detection and clearance. A key aim in the cancer field is therefore to design interventions that can break immunological tolerance and halt cancer progression, whereas on the contrary allergen immunotherapy exactly aims to induce tolerance. In this position paper, we review insights on immune tolerance derived from allergy and from cancer inflammation, focusing on what is known about the roles of key immune cells and mediators...
September 16, 2017: Allergy
https://www.readbyqxmd.com/read/28921508/selection-on-skewed-characters-and-the-paradox-of-stasis
#11
Suzanne Bonamour, Céline Teplitsky, Anne Charmantier, Pierre-André Crochet, Luis-Miguel Chevin
Observed phenotypic responses to selection in the wild often differ from predictions based on measurements of selection and genetic variance. An overlooked hypothesis to explain this paradox of stasis is that a skewed phenotypic distribution affects natural selection and evolution. We show through mathematical modelling that, when a trait selected for an optimum phenotype has a skewed distribution, directional selection is detected even at evolutionary equilibrium, where it causes no change in the mean phenotype...
September 18, 2017: Evolution; International Journal of Organic Evolution
https://www.readbyqxmd.com/read/28920995/stability-and-partitioning-of-%C3%AE-carotene-in-whey-protein-emulsions-during-storage
#12
W A Fahmi Wan Mohamad, D McNaughton, R Buckow, M A Augustin
Varying the β-carotene (0.1-0.3 g kg(-1)) and whey protein isolate (WPI) (2-20 g kg(-1)) concentrations in an oil-in-water (O/W) emulsion influenced the partitioning and stability of β-carotene upon 30 d storage at 25 and 40 °C. The total β-carotene in the emulsion was extracted with a solvent and quantified using UV/visible spectroscopy. The β-carotene in oil phase was obtained using in situ Raman micro-spectroscopy. The β-carotene in the aqueous phase was obtained by difference. Increasing β-carotene concentration resulted in increased partitioning of β-carotene into the aqueous phase whereas increasing WPI concentration had the opposite effect...
September 18, 2017: Food & Function
https://www.readbyqxmd.com/read/28920938/partial-breaking-of-the-coulombic-ordering-of-ionic-liquids-confined-in-carbon-nanopores
#13
Ryusuke Futamura, Taku Iiyama, Yuma Takasaki, Yury Gogotsi, Mark J Biggs, Mathieu Salanne, Julie Ségalini, Patrice Simon, Katsumi Kaneko
Ionic liquids are composed of equal quantities of positive and negative ions. In the bulk, electrical neutrality occurs in these liquids due to Coulombic ordering, in which ion shells of alternating charge form around a central ion. Their structure under confinement is far less well understood. This hinders the widespread application of ionic liquids in technological applications. Here we use scattering experiments to resolve the structure of a widely used ionic liquid (EMI-TFSI) when it is confined inside nanoporous carbons...
September 18, 2017: Nature Materials
https://www.readbyqxmd.com/read/28920124/a-family-of-one-dimensional-lanthanide-complexes-bridged-by-two-distinct-carboxylate-ligands-with-the-dy-analogue-displaying-magnetic-relaxation-behaviour
#14
Wen-Hua Zhu, Xia Xiong, Chen Gao, Shan Li, Yan Zhang, Juan Wang, Chi Zhang, Annie K Powell, Song Gao
A series of isostructural lanthanide one-dimensional (1D) chain complexes, [Ln(INNO)(Bza)2(H2O)2]·(H2O) {INNO = isonicotinate N-oxide, Bza = benzoic acid; Nd(1), Eu(2), Gd(3), Tb(4), Dy(5), Er(6) and Y(7)}, have been successfully isolated by hydrothermal reactions utilizing two distinct carboxylates as co-ligands. Due to the similar steric hindrance of the two carboxylic ligands, the neighboring lanthanide ions are bridged simultaneously by their carboxyl groups from the opposite sides to form a 1D chain structure...
September 18, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/28920078/notch1-activation-depletes-the-pool-of-side-population-stem-cells-in-atl
#15
Xue Tao Bai, Chien-Hung Yeh, Christophe Nicot
BACKGROUND: HTLV-I infection is associated with the development of adult T-cell leukemia (ATL), a malignancy characterized by a high rate of disease relapse and poor survival. Previous studies reported the existence of side population (SP) cells in HTLV-I Tax transgenic mouse models. These studies showed that these ATL-like derived SP cells have both self-renewal and leukemia renewal capacity and represent Cancer Stem Cells (CSC)/Leukemia-Initiating Cells (LIC). Since CSC/LIC are resistant to conventional therapies, a better characterization is needed...
June 2017: Journal of Cancer Sciences
https://www.readbyqxmd.com/read/28919598/risk-factors-and-immediate-outcome-of-very-low-birth-weight-babies-appropriate-for-gestational-age-in-newly-established-scanu-mymensingh-medical-college-hospital
#16
K Begum, M N Islam, M A Hossain, M A Ali, M K Islam, M A Islam, M Salim, M Oliullah
Low birth weight (LBW) is the most important preventable cause in the neonatal period leading to very high neonatal mortality and morbidity in developing countries like Bangladesh. A cross sectional study was conducted in the neonatology ward, Mymensingh Medical College Hospital, Mymensingh from July 2014 to December 2014 to identify the risk factors and immediate hospital outcome of Very Low Birth Weight (VLBW) Appropriate for Gestational Age (AGA) babies in context of present neonatal hospital care standard...
July 2017: Mymensingh Medical Journal: MMJ
https://www.readbyqxmd.com/read/28919514/hz-6d-targeted-herc5-to-regulate-p53-isgylation-in-human-hepatocellular-carcinoma
#17
Yang Wang, Qi Ding, Tao Xu, Chang-Yao Li, Dan-Dan Zhou, Lei Zhang
Manipulating the posttranslational modulator of p53 is central in the regulation of its activity and function. ISGylated p53 can be degraded by the 20S proteasome. During this process, HERC5/Ceb1, an IFN-induced HECT-type E3 ligase, mediated p53 ISGylation. In this study, we indicated that HERC5 was over-expressed in both HCC tissue samples and cell lines. Knockdown of HERC5 significantly induced the expression of p53, p21 and Bax/Bcl-2 in HCC cells, resulting in apoptosis augment. Whereas, opposite results were obtained by using HERC5 over-expression...
September 14, 2017: Toxicology and Applied Pharmacology
https://www.readbyqxmd.com/read/28919480/cholesterol-modulates-the-cellular-localization-of-orai1-channels-and-its-disposition-among-membrane-domains
#18
A Bohórquez-Hernández, Enrico Gratton, Jonathan Pacheco, Alexander Asanov, Luis Vaca
Store Operated Calcium Entry (SOCE) is one of the most important mechanisms for calcium mobilization in to the cell. Two main proteins sustain SOCE: STIM1 that acts as the calcium sensor in the endoplasmic reticulum (ER) and Orai1 responsible for calcium influx upon depletion of ER. There are many studies indicating that SOCE is modulated by the cholesterol content of the plasma membrane (PM). However, a myriad of questions remain unanswered concerning the precise molecular mechanism by which cholesterol modulates SOCE...
September 12, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28919453/testosterone-promotes-anxiolytic-like-behavior-in-gonadectomized-male-rats-via-blockade-of-the-5-ht1a-receptors
#19
Julia Fedotova, Lucian Hritcu
This study was designed to examine an anxiety-like behavior in the adult gonadectomized (GDX) male rats subjected to testosterone propionate (TP) treatment alone or in combination with 8-OH-DPAT, a 5-HT1A receptor agonist, or with NAN-190, 5-HT1A receptor antagonist. Two weeks after gonadectomy, GDX rats were subjected by treatments with the solvent, TP (0.5 mg/kg, s.c.), 8-OH-DPAT (0.05 mg/kg, s.c.), NAN-190 (0.1 mg/kg, i.p.), TP in combination with 8-OH-DPAT or NAN-190 during 14 days. Anxiety behavior was assessed in the elevated plus maze (EPM) and the open field test (OFT)...
September 14, 2017: General and Comparative Endocrinology
https://www.readbyqxmd.com/read/28919408/neural-oscillations-reflect-latent-learning-states-underlying-dual-context-sensorimotor-adaptation
#20
Justin M Fine, Dalton Moore, Marco Santello
Recent studies have suggested that individuals can form multiple motor memories when simultaneously adapting to multiple, but oppositely-oriented perturbations. These findings predict that individuals detect the change in learning context, allowing the selective initialization and update of motor memories. However, previous electrophysiological studies of sensorimotor adaptation have not identified a neural mechanism supporting the detection of a context switch and adaptation to separate contexts. Here, we tested the hypothesis that such a mechanism is identifiable through neural oscillations measured through EEG...
September 14, 2017: NeuroImage
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