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Guangming Wang, Jinlu Yu
INTRODUCTION: Chronic subdural hematoma(CSDH) can be treated by a relatively simple burr hole surgery. Acute subarachnoid hemorrhage (SAH) occurring after surgery for CSDH has been reported as a rare but severe complication. CASE REPORT: An 88-year-old female complained of progressive headache and dizziness for one month. A right fronto-temporo-parietal CSDH with a shift in the midline structures and lateral ventricle compression was shown by computed tomography (CT) scans...
March 3, 2018: International Journal of Surgery Case Reports
Regina G Belz, Marjo Patama, Aki Sinkkonen
Toxicants are known to have negligible or stimulatory, i.e. hormetic, effects at low doses below those that decrease the mean response of a plant population. Our earlier observations indicated that at such low toxicant doses the growth of very fast- and slow-growing seedlings is selectively altered, even if the population mean remains constant. Currently, it is not known how common these selective low-dose effects are, whether they are similar among fast- and slow-growing seedlings, and whether they occur concurrently with hormetic effects...
March 9, 2018: Science of the Total Environment
Sandra P Amaral, Maun H Tawara, Marcos Fernandez-Villamarin, Erea Borrajo, José Martínez-Costas, Anxo Vidal, Ricardo Riguera, Eduardo Fernandez-Megia
Herein we describe that the generation of dendrimers represents a powerful tool in the control of the size and biodistribution of polyion complexes (PIC). Using a combinatorial screening of six dendrimers (18-243 terminal groups) and five oppositely charged PEGylated copolymers, a dendrimer to PIC hierarchical transfer of structural information was revealed with PIC diameters that increased from 80 to 500 nm on decreasing the dendrimer generation. This rise in size, also accompanied by a micelle to vesicle transition, is interpreted according to a cone- to rod-shaped progression in the architecture of the unit PIC (uPIC)...
March 12, 2018: Angewandte Chemie
Miaomiao Xing, Chao Sun, Hailong Li, Shilin Hu, Lei Lei, Jungen Kang
Cabbage (Brassica oleracea L. var. capitata), an important vegetable crop in the Brassicaceae family, is economically important worldwide. In the process of hybrid seed production, Ogura cytoplasmic male sterility (OguCMS), controlled by the mitochondrial gene orf138, has been extensively used for cabbage hybrid production with complete and stable male sterility. To identify the critical genes and pathways involved in the sterility and to better understand the underlying molecular mechanisms, the anther of OguCMS line R2P2CMS and the fertile line R2P2 were used for RNA-seq and iTRAQ (Isobaric Tags for Relative and Absolute Quantitation) proteome analysis...
2018: PloS One
Thomas W Winkler, Caroline Brandl, Felix Grassmann, Mathias Gorski, Klaus Stark, Julika Loss, Bernhard H F Weber, Iris M Heid
Late-stage age-related macular degeneration (AMD) is the leading cause of visual impairment in the elderly with a complex etiology. The most important non-modifiable risk factors for onset and progression of late AMD are age and genetic risk factors, however, little is known about the interplay between genetics and age or sex. Here, we conducted a large-scale age- and sex-stratified genome-wide association study (GWAS) using 1000 Genomes imputed genome-wide and ExomeChip data (>12 million variants). The data were established by the International Age-related Macular Degeneration Genomics Consortium (IAMDGC) from 16,144 late AMD cases and 17,832 controls...
2018: PloS One
Hao Ge, Pingping Wu, Hong Qian, Sunney Xiaoliang Xie
Within an isogenic population, even in the same extracellular environment, individual cells can exhibit various phenotypic states. The exact role of stochastic gene-state switching regulating the transition among these phenotypic states in a single cell is not fully understood, especially in the presence of positive feedback. Recent high-precision single-cell measurements showed that, at least in bacteria, switching in gene states is slow relative to the typical rates of active transcription and translation...
March 12, 2018: PLoS Computational Biology
Cliff McKinney, Melanie Stearns, Erica Szkody
The current study examined the indirect effect of maternal and paternal emotional and physical maltreatment on affective and behavioral symptoms of oppositional defiant disorder (ODD) through parent-child relationship quality; gender and overall ODD symptoms were examined as moderators. Participants included 2,362 emerging adults who completed questionnaires about parental emotional and physical maltreatment, parent-child relationship quality, and affective and behavioral ODD symptoms. These characteristics were compared across parent and child gender (i...
March 1, 2018: Journal of Interpersonal Violence
Shyam Kumar, Ulhas Sonar, Iqbal Singh
The incidence of fragility fractures of the humerus is increasing worldwide. Although clinicians are aware of fractures of hips and wrists, fractures of the shoulder and elbow do not receive much attention. A considerable proportion of the elderly population (estimated at 10-24%) is dependent on walking aids. A well-functioning and pain-free shoulder and elbow is essential for use of these aids. The impact of loss of mobility in the elderly is well known, hence the overall impact of these fractures on the individual can be considerable...
March 2, 2018: British Journal of Hospital Medicine
Pichamon Limcharoenchat, Sarah E Buchholz, Michael K James, Nicole O Hall, Elliot T Ryser, Bradley P Marks
Inoculation methods in pathogen inactivation studies ideally represent conditions that might occur in real-world scenarios. Surface contamination in or on low-moisture foods affects Salmonella thermal resistance, which is critically important for process validation applications. The objective of this study was to quantify the effect of inoculation protocol on the thermal resistance of Salmonella Enteritidis PT 30 in fabricated low-moisture foods. Almond meal, almond butter, wheat meal, wheat flour, and date paste were inoculated via prefabrication and postfabrication protocols...
March 12, 2018: Journal of Food Protection
Randi Starrfelt, Solja K Klargaard, Anders Petersen, Christian Gerlach
OBJECTIVE: Recent models suggest that face and word recognition may rely on overlapping cognitive processes and neural regions. In support of this notion, face recognition deficits have been demonstrated in developmental dyslexia. Here we test whether the opposite association can also be found, that is, impaired reading in developmental prosopagnosia. METHOD: We tested 10 adults with developmental prosopagnosia and 20 matched controls. All participants completed the Cambridge Face Memory Test, the Cambridge Face Perception test and a Face recognition questionnaire used to quantify everyday face recognition experience...
February 2018: Neuropsychology
Olga Vladimirovna Ezhova, Vladimir Vasil'yevich Malakhov, Ekaterina Alekseevna Egorova
Studies of echinoid microscopic anatomy over the last two centuries have created a number of inaccuracies and mistakes that have accumulated in the descriptions of the intricate organization of the coelomic system of Echinoidea. To clarify the situation, we reconstructed the axial complex and radial complex of the echinoid Strongylocentrotus pallidus. The water ring is located between the perivisceral coelom and the perioral coelom. The oral haemal ring lies between the coelothelia of the water-vascular, perivisceral, and perioral rings...
March 12, 2018: Journal of Morphology
Valentina Proietti, Marta Rigoldi, Emanuela Croci, Viola Macchi Cassia
During the first year of life face discrimination abilities narrow toward adult human faces of the most frequently encountered ethnic group/s. Earlier studies showed that perceptual learning under laboratory-training protocols can modulate this narrowing process. Here we investigated whether natural experience acquired in everyday settings with an older sibling's face can shape the trajectory of perceptual narrowing towards adult faces. Using an infant-controlled habituation procedure we measured discrimination of adult (Experiment 1) and child faces (Experiment 2) in 3- and 9- month-old infants with and without a child sibling...
March 12, 2018: Developmental Psychobiology
M Bilgehan Pektas, Ozge Turan, Gozde Ozturk Bingol, Esra Sumlu, Gökhan Sadi, Fatma Akar
Transient elevations in blood glucose level may lead to changes in vascular function. Herein, we investigated the effects of high-glucose or high-fructose challenge as well as potential influence of juglone or resveratrol on vascular reactivity, Akt/eNOS and insulin signaling effectors in rat aorta. Aortic segments of rats were incubated with high-glucose (30 mM) or high-fructose (2 mM) in the absence and presence of juglone (5 μM) or resveratrol (10 μM). Acute high-glucose incubation markedly decreased acetylcholine-induced relaxation, which is further inhibited by juglone, but ameliorated by resveratrol...
March 10, 2018: Canadian Journal of Physiology and Pharmacology
Ying Liu, Lihong Ren, Wenjing Liu, Zhibo Xiao
MiR-21 has been found to be up-regulated in keloid tissue and affect the proliferation and apoptosis of keloid fibroblasts. However, the possible related mechanisms remain unclear. In this study, we aimed to evaluate the role of miR-21 in FasL-induced caspase-8 activation and mitochondrial-mediated apoptotic signaling pathway in keloid fibroblasts. According to the present study, the protein level of FasL was decreased by miR-21 overexpression, while enhanced by miR-21 inhibition in keloid fibroblasts. Subsequently, the mitochondrial-mediated apoptosis of keloid fibroblasts was restrained by miR-21 overexpression as evidenced by enhanced mitochondria membrane potential and decreased production of mitochondrial ROS...
March 10, 2018: Biochemistry and Cell Biology, Biochimie et Biologie Cellulaire
R Murín, M Abdalla, N Murínová, J Hatok, D Dobrota
The fundamental biochemical processes of 5-methylcytosine (5-mC) synthesis, maintenance, conversion and removal determine the time and spatial pattern of DNA methylation. This has a strong effect on a plethora of physiological aspects of cellular metabolism. While the presence of 5-mC within the promoter region can silence gene expression, its derivative - 5-hydroxymethylcytosine exerts an opposite effect. Dysregulations in the metabolism of 5-mC lead to an altered DNA methylation pattern which is linked with a disrupted epigenome, and are considered to play a significant part in the etiology of several human diseases...
March 12, 2018: Physiological Research
Jon Cavanaugh, Aaryn Mustoe, Jeffrey A French
While separation from significant social partners produces a host of neurobiological and behavioral perturbations, including behavioral distress and increased glucocorticoid production, positive social interactions upon reunion are critical for the reestablishment of normative relationship dynamics and the attenuation of the biobehavioral stress response. The hormone oxytocin has critical and pervasive roles in reproductive and behavioral processes across the lifespan, and plays a particularly prominent role in social bonding...
March 11, 2018: American Journal of Primatology
Egor A Kolesov, Mikhail S Tivanov, Olga V Korolik, Olesya O Kapitanova, Xiao Fu, Hak Dong Cho, Tae Won Kang, Gennady N Panin
Atmospheric doping of supported graphene was investigated by Raman scattering under different pressures. Various Raman spectra parameters were found to depend on the pressure and the substrate material. The results are interpreted in terms of atmospheric adsorption leading to a change in graphene charge carrier density and the effect of the substrate on the electronic and phonon properties of graphene. It was found that adsorption of molecules from the atmosphere onto graphene doped with nitrogen (electron doping) compensates for the electron charge...
2018: Beilstein Journal of Nanotechnology
Satomi Minato, Kaori Kitaoka, Mika Takeuchi, Ayaka Tsuboi, Miki Kurata, Shigehiro Tanaka, Tsutomu Kazumi, Keisuke Fukuo
Objective: We test the hypothesis that aspartate aminotransferase (AST) may be associated inversely with serum triglycerides (TG) and positively with high density lipoprotein (HDL) cholesterol in young athletes because athletes have larger amounts of muscle mass. Research design and methods: Pearson's correlation coefficients were calculated between serum AST and alanine aminotransferase (ALT) and body composition identified by dual-energy X-ray absorptiometry, markers of insulin resistance, serum lipids, lipoproteins, apolipoproteins, adiponectin and leptin in 174 female collegiate athletes (18-22 years)...
2018: BMJ Open Diabetes Research & Care
Ling Shih Quek, Nicolas Grasset, Joanita Binte Jasmen, Kim S Robinson, Sophie Bellanger
Cdc20 and Cdh1 activate the Anaphase Promoting Complex/Cyclosome (APC/C), a master cell cycle regulator. Although cell cycle modifications occur during differentiation of stem cells, a role for the APC/C on stem cell fate has not been established in embryonic or adult human tissues. We found that differentiated human primary keratinocytes (HPKs) from the skin express extremely low levels of Cdc20 compared to HPK stem cells (holoclones). In agreement with this, staining of human skin biopsies showed that Cdc20 is expressed in occasional cells from the basal and epibasal layers of the epidermis and is absent from the differentiated layers...
March 8, 2018: Journal of Investigative Dermatology
Zhiqiang Wu, Ting Wang, Meng Fang, Wending Huang, Zhengwang Sun, Jianru Xiao, Wangjun Yan
Breast cancer accounts for about 30% of all cancers in women, while approximately 70% breast cancer patients developed bone metastases throughout the course of their disease, highlighting the importance of exploring new therapeutic targets. Microfibrillar-associated protein 5 (MFAP5) is a component of extracellular elastic microfibril which has been confirmed to function in tissue development and cancer progression. But the role of MFAP5 in breast cancer remains unclear. The present study demonstrated that MFAP5 was up-regulated in breast cancers compared with that in normal breast tissues, and further increased in breast cancer bone metastasis...
March 8, 2018: Biochemical and Biophysical Research Communications
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