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https://www.readbyqxmd.com/read/28426845/her2-specific-chimeric-antigen-receptor-modified-virus-specific-t-cells-for-progressive-glioblastoma-a-phase-1-dose-escalation-trial
#1
Nabil Ahmed, Vita Brawley, Meenakshi Hegde, Kevin Bielamowicz, Mamta Kalra, Daniel Landi, Catherine Robertson, Tara L Gray, Oumar Diouf, Amanda Wakefield, Alexia Ghazi, Claudia Gerken, Zhongzhen Yi, Aidin Ashoori, Meng-Fen Wu, Hao Liu, Cliona Rooney, Gianpietro Dotti, Adrian Gee, Jack Su, Yvonne Kew, David Baskin, Yi Jonathan Zhang, Pamela New, Bambi Grilley, Milica Stojakovic, John Hicks, Suzanne Z Powell, Malcolm K Brenner, Helen E Heslop, Robert Grossman, Winfried S Wels, Stephen Gottschalk
Importance: Glioblastoma is an incurable tumor, and the therapeutic options for patients are limited. Objective: To determine whether the systemic administration of HER2-specific chimeric antigen receptor (CAR)-modified virus-specific T cells (VSTs) is safe and whether these cells have antiglioblastoma activity. Design, Setting, and Participants: In this open-label phase 1 dose-escalation study conducted at Baylor College of Medicine, Houston Methodist Hospital, and Texas Children's Hospital, patients with progressive HER2-positive glioblastoma were enrolled between July 25, 2011, and April 21, 2014...
April 20, 2017: JAMA Oncology
https://www.readbyqxmd.com/read/28419355/vegetable-garden-as-therapeutic-horticulture-for-patients-with-chronic-pain
#2
John S Quick, Sarah B Robishaw, Kelly A Baylor, Dawn I Snyder, John J Han
No abstract text is available yet for this article.
April 17, 2017: Pain Medicine: the Official Journal of the American Academy of Pain Medicine
https://www.readbyqxmd.com/read/28410720/secondary-intraocular-lens-implantation-complication-rates-visual-acuity-and-refractive-outcomes
#3
Greg Brunin, Ahmar Sajjad, Eric J Kim, Ildamaris Montes de Oca, Mitchell P Weikert, Li Wang, Douglas D Koch, Zaina Al-Mohtaseb
PURPOSE: To compare complication rates, visual acuity, and refractive outcomes of secondary intraocular lens (IOLs) implantation. SETTING: Department of Ophthalmology, Cullen Eye Institute, Baylor College of Medicine, Houston, Texas, USA. DESIGN: Retrospective case series. METHODS: All secondary IOLs placed by the anterior segment service were reviewed. Preoperative data, operative reports, and data from each subsequent postoperative visit were evaluated...
March 2017: Journal of Cataract and Refractive Surgery
https://www.readbyqxmd.com/read/28410715/comparison-of-astigmatic-prediction-errors-associated-with-new-calculation-methods-for-toric-intraocular-lenses
#4
Tiago B Ferreira, Paulo Ribeiro, Filomena J Ribeiro, João G O'Neill
PURPOSE: To compare the prediction errors in residual astigmatism associated with new calculation methods for toric intraocular lenses (IOLs). SETTING: Hospital da Luz, Lisbon, Portugal. DESIGN: Retrospective case series. METHODS: In eyes having cataract surgery with toric IOL implantation (Acrysof IQ), the predicted residual astigmatism by each calculation method was compared with the manifest refractive astigmatism...
March 2017: Journal of Cataract and Refractive Surgery
https://www.readbyqxmd.com/read/28405096/cardiac-rehabilitation-for-a-skydiver-after-aortic-valve-replacement-for-pure-aortic-regurgitation-and-resection-of-the-ascending-aorta-complicated-by-active-infective-endocarditis-and-heart-block-requiring-a-pacemaker
#5
Tonja R Solomon, Sandra DeJong, Tim Bilbrey, Pasquale Carbone, Mark Campbell, Robert D Parker, Alessandra Lira, Diogo Amarante, Jeffrey M Schussler, Jenny Adams
A professional skydiver underwent aortic valve and ascending aorta replacement complicated by infective endocarditis with root abscess and pacemaker implantation. He then enrolled in the Baylor Heart and Vascular Hospital cardiac rehabilitation (CR) program as part of its specificity of testing and exercise training facility. He performed specific skydiving cardiovascular and muscular strength tests at the beginning and the end of the CR program. His pacemaker was interrogated to ascertain any arrhythmias or lead displacement over the course of the CR program...
April 2017: Proceedings of the Baylor University Medical Center
https://www.readbyqxmd.com/read/28404607/interpreting-incidentally-identified-variants-in-genes-associated-with-catecholaminergic-polymorphic-ventricular-tachycardia-in-a-large-cohort-of-clinical-whole-exome-genetic-test-referrals
#6
Andrew P Landstrom, Andrew L Dailey-Schwartz, Jill A Rosenfeld, Yaping Yang, Margaret J McLean, Christina Y Miyake, Santiago O Valdes, Yuxin Fan, Hugh D Allen, Daniel J Penny, Jeffrey J Kim
BACKGROUND: The rapid expansion of genetic testing has led to increased utilization of clinical whole-exome sequencing (WES). Clinicians and genetic researchers are being faced with assessing risk of disease vulnerability from incidentally identified genetic variants which is typified by variants found in genes associated with sudden death-predisposing catecholaminergic polymorphic ventricular tachycardia (CPVT). We sought to determine whether incidentally identified variants in genes associated with CPVT from WES clinical testing represent disease-associated biomarkers...
April 2017: Circulation. Arrhythmia and Electrophysiology
https://www.readbyqxmd.com/read/28383545/the-collaborative-african-genomics-network-training-program-a-trainee-perspective-on-training-the-next-generation-of-african-scientists
#7
Busisiwe C Mlotshwa, Savannah Mwesigwa, Gerald Mboowa, Lesedi Williams, Gaone Retshabile, Adeodata Kekitiinwa, Misaki Wayengera, Samuel Kyobe, Chester W Brown, Neil A Hanchard, Graeme Mardon, Moses Joloba, Gabriel Anabwani, Sununguko W Mpoloka
PURPOSE: The Collaborative African Genomics Network (CAfGEN) aims to establish sustainable genomics research programs in Botswana and Uganda through long-term training of PhD students from these countries at Baylor College of Medicine. Here, we present an overview of the CAfGEN PhD training program alongside trainees' perspectives on their involvement. BACKGROUND: Historically, collaborations between high-income countries (HICs) and low- and middle-income countries (LMICs), or North-South collaborations, have been criticized for the lack of a mutually beneficial distribution of resources and research findings, often undermining LMICs...
April 6, 2017: Genetics in Medicine: Official Journal of the American College of Medical Genetics
https://www.readbyqxmd.com/read/28366376/negative-dysphotopsia-causes-and-rationale-for-prevention-and-treatment
#8
Jack T Holladay, Michael J Simpson
PURPOSE: To determine the cause of negative dysphotopsia using standard ray-tracing techniques and identify the primary and secondary causative factors. SETTING: Department of Ophthalmology, Baylor College of Medicine, Houston, Texas, USA. DESIGN: Experimental study. METHODS: Zemax ray-tracing software was used to evaluate pseudophakic and phakic eye models to show the location of retinal field images from various visual field objects...
February 2017: Journal of Cataract and Refractive Surgery
https://www.readbyqxmd.com/read/28366365/intraocular-lens-power-calculations-in-eyes-with-previous-hyperopic-laser-in-situ-keratomileusis-or-photorefractive-keratectomy
#9
Eric B Hamill, Li Wang, Hayley K Chopra, Warren Hill, Douglas D Koch
PURPOSE: To evaluate the accuracy of 7 intraocular lens (IOL) calculation formulas in patients with previous hyperopic laser in situ keratomileusis (LASIK) or excimer laser photorefractive keratectomy (PRK). DESIGN: Retrospective case series. SETTING: Cullen Eye Institute, Baylor College of Medicine, Houston, Texas, and private practice, Mesa, Arizona, USA. METHODS: The 7 formulas evaluated were the adjusted Atlas 0-3, Masket, Modified Masket, Haigis-L, Shammas-PL, Barrett True-K, and Barrett True-K No-History...
February 2017: Journal of Cataract and Refractive Surgery
https://www.readbyqxmd.com/read/28364447/association-between-short-sleep-duration-and-risk-behavior-factors-in-middle-school-students
#10
Judith Owens, Guanghai Wang, Daniel Lewin, Elizabeth Skora, Allison Baylor
Study Objectives: To examine the association between self-reported sleep duration (SD) and peer/individual factors predictive of risky behaviors (risk behavior factors) in a large socioeconomically diverse school-based sample of early adolescents. Design, Setting, and Participants: Survey data collected from 10718 and 11240 eighth-grade students in 2010 and 2012, respectively, were analyzed. Intervention: N/A. Measurements and Results: Self-reported school night SD was grouped as ≤4 hours, 5 hours, 6 hours, 7 hours, 8 hours, 9 hours, and ≥10 hours...
January 1, 2017: Sleep
https://www.readbyqxmd.com/read/28346206/the-international-academy-of-compounding-pharmacists-introduces-a-new-president
#11
Baylor Rice
No abstract text is available yet for this article.
March 2017: International Journal of Pharmaceutical Compounding
https://www.readbyqxmd.com/read/28331005/-100m-africa-initiative-targets-childhood-cancer
#12
(no author information available yet)
The Bristol-Myers Squibb Foundation have teamed up with Texas Children's Cancer and Hematology Centers and Baylor College of Medicine on a $100 million initiative to improve pediatric cancer care in sub-Saharan Africa. Organizers are partnering with local governments to increase access to specialty care in countries where the mortality rate from cancer in children is as high as 90%.
March 22, 2017: Cancer Discovery
https://www.readbyqxmd.com/read/28314425/characteristics-of-hearts-at-necropsy-in-patients-treated-chronically-with-prednisone-the-corticosteroid-heart
#13
William C Roberts, Vera S Won, Anupama Vasudevan, Joseph M Guileyardo
It is known that long-term corticosteroid therapy increases fatty deposits in several human tissues. To quantify the quantity of fatty deposits in the heart in patients on prednisone, we examined the heart at necropsy in 37 patients who had received long-term corticosteroid therapy (prednisone in 34) and compared certain findings in them to those in 194 (steroid-naïve) patients also studied at necropsy at Baylor University Medical Center, Dallas, in a 3-year period (2013, 2014, and 2015). Significant differences between the 2 groups were found in age, gender, and frequency of coronary artery disease but not in body mass index, frequency of massive cardiac adiposity, heart weight, or frequency of systemic hypertension or diabetes mellitus...
December 15, 2016: American Journal of Cardiology
https://www.readbyqxmd.com/read/28289684/polyprenyl-immunostimulant-in-feline-rhinotracheitis-randomized-placebo-controlled-experimental-and-field-safety-studies
#14
Alfred M Legendre, Tanya Kuritz, Robert Eric Heidel, Vivian M Baylor
Feline rhinotracheitis is a ubiquitous disease caused by feline herpesvirus type 1 (FHV-1). The disease is easily transmissible and common in multi-cat environments where even vaccinated cats can develop clinical signs of respiratory or ocular disease or both when exposed to the virus. Prior to the work reported here, there was no licensed treatment for the disease on the market. We hypothesized that polyprenyl immunostimulant (PI), an immunomodulatory veterinary biologic, would be useful in treating feline rhinotracheitis by reducing the severity of respiratory or/and ocular disease...
2017: Frontiers in Veterinary Science
https://www.readbyqxmd.com/read/28286843/clinical-scoring-systems-in-predicting-the-outcome-of-acute-upper-gastrointestinal-bleeding-a-narrative-review
#15
REVIEW
Hanieh Ebrahimi Bakhtavar, Hamid Reza Morteza Bagi, Farzad Rahmani, Kavous Shahsavari Nia, Arezu Ettehadi
Prediction of the outcome and severity of acute upper gastrointestinal bleeding (UGIB) has significant importance in patient care, disposition, and determining the need for emergent endoscopy. Recent international recommendations endorse using scoring systems for management of non-variceal UGIB patients. To date, different scoring systems have been developed for predicting the risk of 30-day mortality and re-bleeding. We have discussed the screening performance characteristics of Baylor bleeding score, the Rockall risk scoring score, Cedars-Sinai Medical Center predictive index, Glasgow Blatchford score, T-score, and AIMS65 systems, in the present review...
2017: Emergency (Tehran, Iran)
https://www.readbyqxmd.com/read/28272539/choices-for-return-of-primary-and-secondary-genomic-research-results-of-790-members-of-families-with-mendelian-disease
#16
Katie Fiallos, Carolyn Applegate, Debra Jh Mathews, Juli Bollinger, Amanda L Bergner, Cynthia A James
Although consensus is building that primary (PR) and secondary findings (SF) from genomic research should be offered to participants under some circumstances, data describing (1) actual choices of study participants and (2) factors associated with these choices are limited, hampering study planning. We conducted a cross-sectional analysis of choices made for return of PR and SF during informed consent by members of the first 247 families (790 individuals) enrolled in the Baylor-Hopkins Center for Mendelian Genomics, a genome sequencing study...
May 2017: European Journal of Human Genetics: EJHG
https://www.readbyqxmd.com/read/28267605/chairmen-in-academic-urologic-practice-a-descriptive-analysis
#17
Nicholas J Farber, Brian J Friel, Young S Kwon, Andrew Cruz, Sammy E Elsamra
OBJECTIVE: To examine and characterize the demographics and scholarly characteristics of academic urology chairmen at the time of appointment. MATERIALS AND METHODS: The chairman of each United States urology residency program as of September 2016 was included in the study. Interim chairmen, as well as programs for which no clearly defined chair could be identified, were excluded. Demographic and academic data were collected via publically available curriculum vitae, departmental websites, Google search engine, and PubMed and Scopus websites...
March 4, 2017: Urology
https://www.readbyqxmd.com/read/28267463/early-inpatient-calculation-of-laboratory-based-30-day-readmission-risk-scores-empowers-clinical-risk-modification-during-index-hospitalization
#18
Benjamin D Horne, Deborah Budge, Andrew L Masica, Lucy A Savitz, José Benuzillo, Gabriela Cantu, Alejandra Bradshaw, Raymond O McCubrey, Tami L Bair, Colleen A Roberts, Kismet D Rasmusson, Rami Alharethi, Abdallah G Kfoury, Brent C James, Donald L Lappé
Improving 30-day readmission continues to be problematic for most hospitals. This study reports the creation and validation of sex-specific inpatient (i) heart failure (HF) risk scores using electronic data from the beginning of inpatient care for effective and efficient prediction of 30-day readmission risk. METHODS: HF patients hospitalized at Intermountain Healthcare from 2005 to 2012 (derivation: n=6079; validation: n=2663) and Baylor Scott & White Health (North Region) from 2005 to 2013 (validation: n=5162) were studied...
March 2017: American Heart Journal
https://www.readbyqxmd.com/read/28261584/polyprenyl-immunostimulant-treatment-of-cats-with-presumptive-non-effusive-feline-infectious-peritonitis-in-a-field-study
#19
Alfred M Legendre, Tanya Kuritz, Gina Galyon, Vivian M Baylor, Robert Eric Heidel
Feline infectious peritonitis (FIP) is a fatal disease with no clinically effective treatment. This field study evaluated treatment with Polyprenyl Immunostimulant (PI) in cats with the non-effusive form of FIP. Because immune suppression is a major component in the pathology of FIP, we hypothesized that treatment with an immune system stimulant would increase survival times of cats with dry FIP. Sixty cats, diagnosed with dry FIP by primary care and specialist veterinarians and meeting the acceptance criteria, were treated with PI without intentional selection of less severe cases...
2017: Frontiers in Veterinary Science
https://www.readbyqxmd.com/read/28257550/tolerability-of-switch-to-macitentan-from-bosentan-in-pulmonary-arterial-hypertension
#20
Zeenat Safdar, Aishwarya Thakur, Adaani Frost
OBJECTIVES: Pulmonary arterial hypertension (PAH) is a progressive disease that can be treated with several medications. Macitentan, an endothelin receptor antagonist (ERA), has received approval as a PAH therapy. We report our data regarding the tolerability in patients with PAH who were switched from bosentan to macitentan. METHODS: At the Baylor Pulmonary Hypertension Program, 24 patients with PAH who had been taking bosentan and were switched to macitentan were identified in this retrospective study...
March 2017: Southern Medical Journal
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