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https://www.readbyqxmd.com/read/27910428/design-of-a-digital-holography-system-for-pfc-erosion-measurements-on-proto-mpex
#1
C E Tommy Thomas, T M Biewer, L R Baylor, S K Combs, S J Meitner, J Rapp, D L Hillis, E M Granstedt, R Majeski, R Kaita
A project has been started at ORNL to develop a dual-wavelength digital holography system for plasma facing component erosion measurements on prototype material plasma exposure experiment. Such a system will allow in situ real-time measurements of component erosion. Initially the system will be developed with one laser, and first experimental laboratory measurements will be made with the single laser system. In the second year of development, a second CO2 laser will be added and measurements with the dual wavelength system will begin...
November 2016: Review of Scientific Instruments
https://www.readbyqxmd.com/read/27880765/mechanisms-for-complex-chromosomal-insertions
#2
Shen Gu, Przemyslaw Szafranski, Zeynep Coban Akdemir, Bo Yuan, Mitchell L Cooper, Maria A Magriñá, Carlos A Bacino, Seema R Lalani, Amy M Breman, Janice L Smith, Ankita Patel, Rodger H Song, Weimin Bi, Sau Wai Cheung, Claudia M B Carvalho, Paweł Stankiewicz, James R Lupski
Chromosomal insertions are genomic rearrangements with a chromosome segment inserted into a non-homologous chromosome or a non-adjacent locus on the same chromosome or the other homologue, constituting ~2% of nonrecurrent copy-number gains. Little is known about the molecular mechanisms of their formation. We identified 16 individuals with complex insertions among 56,000 individuals tested at Baylor Genetics using clinical array comparative genomic hybridization (aCGH) and fluorescence in situ hybridization (FISH)...
November 2016: PLoS Genetics
https://www.readbyqxmd.com/read/27799506/personalized-treatment-for-a-patient-with-a-braf-v600e-mutation-using-dabrafenib-and-a-tumor-treatment-fields-device-in-a-high-grade-glioma-arising-from-ganglioglioma
#3
Silviya K Meletath, Dean Pavlick, Tim Brennan, Roy Hamilton, Juliann Chmielecki, Julia A Elvin, Norma Palma, Jeffrey S Ross, Vincent A Miller, Philip J Stephens, George Snipes, Veena Rajaram, Siraj M Ali, Isaac Melguizo-Gavilanes
BACKGROUND: Gangliogliomas are slow-growing, low-grade central nervous system tumors affecting children and young adults. However, some patients will experience tumor recurrence and/or malignant progression. This article reports on the clinical history, molecular findings, and treatment response in a patient with BRAF V600-mutated high-grade glioma arising from ganglioglioma. METHODS: Hematoxylin-eosin staining and comprehensive genomic profiling via Foundation One were performed on the tumor sample from a male patient undergoing treatment at the Department of Neuro-Oncology at Baylor University Medical Center...
November 2016: Journal of the National Comprehensive Cancer Network: JNCCN
https://www.readbyqxmd.com/read/27760705/clinical-effectiveness-of-a-pylorus-preserving-procedure-on-total-pancreatectomy-with-islet-autotransplantation
#4
Rauf Shahbazov, Gumpei Yoshimatsu, Waqas Z Haque, Omar S Khan, Giovanna Saracino, Michael C Lawrence, Peter T Kim, Nicholas Onaca, Bashoo Naziruddin, Marlon F Levy
BACKGROUND: The impact of pylorus preserving procedures (PP) on total pancreatectomy with islet autotransplantation (TPIAT) has not been examined. This study aimed to investigate the clinical impact of the PP on TPIAT. METHODS: The Baylor Simmons Transplant Institute database was queried to identify seventy-three patients who underwent TPIAT from 2006 to 2014. All patients were investigated in postoperative complications, long-term nutritional status, and graft function...
October 8, 2016: American Journal of Surgery
https://www.readbyqxmd.com/read/27750470/controls-can-t-be-ignored
#5
William Peacock
Dear Editor I read with great interest the manuscript titled "A New Panel of Blood Biomarkers for the Diagnosis of Mild Traumatic Brain Injury/Concussion in Adults" by Shan R, et al, published in the January issue of the Journal. (1) I do have some questions. The key to marker discovery studies is a precise and accurate description of how the population was identified, including controls. I have significant concerns about the control population in the manuscript. In the presentation the characteristics of the control group are unclear, described only as "not patients in the ED" and with the same exclusion criteria of the other cohorts...
October 18, 2016: Journal of Neurotrauma
https://www.readbyqxmd.com/read/27750016/towards-the-design-of-less-hazardous-chemicals-exploring-comparative-oxidative-stress-in-two-common-animal-models
#6
Jone Corrales, Lauren A Kristofco, W Baylor Steele, Gavin N Saari, Jakub Kostal, Edward Spencer Williams, Margaret Mills, Evan P Gallagher, Terrance J Kavanagh, Nancy Simcox, Longzhu Q Shen, Fjodor Melnikov, Julie B Zimmerman, Adelina M Voutchkova-Kostal, Paul T Anastas, Bryan W Brooks
Sustainable molecular design of less hazardous chemicals presents a potentially transformative approach to protect public health and the environment. Relationships between molecular descriptors and toxicity thresholds previously identified the octanol-water distribution coefficient, log D, and the HOMO-LUMO energy gap, ∆E, as two useful properties in the identification of reduced aquatic toxicity. To determine whether these two property-based guidelines are applicable to sublethal oxidative stress (OS) responses, two common aquatic in vivo models, the fathead minnow (Pimephales promelas) and zebrafish (Danio rerio), were employed to examine traditional biochemical biomarkers (lipid peroxidation, DNA damage, total glutathione) and antioxidant gene activation following exposure to eight structurally diverse industrial chemicals (bisphenol A, cumene hydroperoxide, dinoseb, hydroquinone, indene, perfluorooctanoic acid, R-(-)-carvone, tert-butyl hydroperoxide)...
October 17, 2016: Chemical Research in Toxicology
https://www.readbyqxmd.com/read/27695166/selection-of-abstracts-from-the-4th-annual-baylor-scott-white-central-texas-research-days
#7
Jennifer Stone, Joni Bailey, Wendy Hegefeld, Hania Wehbe-Janek
No abstract text is available yet for this article.
October 2016: Proceedings of the Baylor University Medical Center
https://www.readbyqxmd.com/read/27695163/development-and-testing-of-baylor-scott-white-health-s-attitudes-and-practices-of-patient-safety-survey
#8
Sunni A Barnes, Jan Compton, Margaret Saldaña, Kristen M Tecson, Chizuko Hastings, Donald A Kennerly
Improving the quality of patient care requires a culture attuned to safety. We describe the development, implementation, and psychometric evaluation of the Attitudes and Practices of Patient Safety Survey (APPSS) within the Baylor Scott & White Health system. The APPSS was designed to enable safety culture data to be collected and aggregated at the unit level to identify high-priority needs. The survey, with 27 Likert-scale core questions divided into 4 concept domains and 2 open-ended questions, was administered electronically to employees with direct patient care responsibilities (n = 16,950)...
October 2016: Proceedings of the Baylor University Medical Center
https://www.readbyqxmd.com/read/27640307/recurrent-de-novo-and-biallelic-variation-of-atad3a-encoding-a-mitochondrial-membrane-protein-results-in-distinct-neurological-syndromes
#9
Tamar Harel, Wan Hee Yoon, Caterina Garone, Shen Gu, Zeynep Coban-Akdemir, Mohammad K Eldomery, Jennifer E Posey, Shalini N Jhangiani, Jill A Rosenfeld, Megan T Cho, Stephanie Fox, Marjorie Withers, Stephanie M Brooks, Theodore Chiang, Lita Duraine, Serkan Erdin, Bo Yuan, Yunru Shao, Elie Moussallem, Costanza Lamperti, Maria A Donati, Joshua D Smith, Heather M McLaughlin, Christine M Eng, Magdalena Walkiewicz, Fan Xia, Tommaso Pippucci, Pamela Magini, Marco Seri, Massimo Zeviani, Michio Hirano, Jill V Hunter, Myriam Srour, Stefano Zanigni, Richard Alan Lewis, Donna M Muzny, Timothy E Lotze, Eric Boerwinkle, Richard A Gibbs, Scott E Hickey, Brett H Graham, Yaping Yang, Daniela Buhas, Donna M Martin, Lorraine Potocki, Claudio Graziano, Hugo J Bellen, James R Lupski
ATPase family AAA-domain containing protein 3A (ATAD3A) is a nuclear-encoded mitochondrial membrane protein implicated in mitochondrial dynamics, nucleoid organization, protein translation, cell growth, and cholesterol metabolism. We identified a recurrent de novo ATAD3A c.1582C>T (p.Arg528Trp) variant by whole-exome sequencing (WES) in five unrelated individuals with a core phenotype of global developmental delay, hypotonia, optic atrophy, axonal neuropathy, and hypertrophic cardiomyopathy. We also describe two families with biallelic variants in ATAD3A, including a homozygous variant in two siblings, and biallelic ATAD3A deletions mediated by nonallelic homologous recombination (NAHR) between ATAD3A and gene family members ATAD3B and ATAD3C...
October 6, 2016: American Journal of Human Genetics
https://www.readbyqxmd.com/read/27634785/association-between-short-sleep-duration-and-risk-behavior-factors-in-middle-school-students
#10
Judith Owens, Guanghai Wang, Daniel Lewin, Elizabeth Skora, Allison Baylor
STUDY OBJECTIVES: To examine the association between self-reported sleep duration (SD) and peer/individual factors predictive of risky behaviors (risk behavior factors) in a large socioeconomically diverse school-based sample of early adolescents. DESIGN, SETTING, AND PARTICIPANTS: Survey data collected from 10,718 and 11,240 8th grade students in 2010 and 2012, respectively, were analyzed. MEASUREMENTS AND RESULTS: Self-reported school-night SD was grouped as ≤4 hours, 5 hours, 6 hours, 7 hours, 8 hours, 9 hours, and ≥10 hours...
September 9, 2016: Sleep
https://www.readbyqxmd.com/read/27612449/a-hybrid-computational-strategy-to-address-wgs-variant-analysis-in-5000-samples
#11
Zhuoyi Huang, Navin Rustagi, Narayanan Veeraraghavan, Andrew Carroll, Richard Gibbs, Eric Boerwinkle, Manjunath Gorentla Venkata, Fuli Yu
BACKGROUND: The decreasing costs of sequencing are driving the need for cost effective and real time variant calling of whole genome sequencing data. The scale of these projects are far beyond the capacity of typical computing resources available with most research labs. Other infrastructures like the cloud AWS environment and supercomputers also have limitations due to which large scale joint variant calling becomes infeasible, and infrastructure specific variant calling strategies either fail to scale up to large datasets or abandon joint calling strategies...
September 10, 2016: BMC Bioinformatics
https://www.readbyqxmd.com/read/27583809/operationalizing-nimh-research-domain-criteria-rdoc-in-naturalistic-clinical-settings
#12
Carla Sharp, J Christopher Fowler, Ramiro Salas, David Nielsen, Jon Allen, John Oldham, Thomas Kosten, Sanjay Mathew, Alok Madan, B Christopher Frueh, Peter Fonagy
Recently, the National Institute of Mental Health (NIMH) introduced the Research Domain Criteria (RDoC) initiative to address two major challenges facing the field of psychiatry: (1) the lack of new effective personalized treatments for psychiatric disorders, and (2) the limitations associated with categorically defined psychiatric disorders. Although the potential of RDoC to revolutionize personalized psychiatric medicine and psychiatric nosology has been acknowledged, it is unclear how to implement RDoC in naturalistic clinical settings as part of routine outcomes research...
2016: Bulletin of the Menninger Clinic
https://www.readbyqxmd.com/read/27571265/cognitively-related-basic-activities-of-daily-living-impairment-greatly-increases-the-risk-of-death-in-alzheimers-disease
#13
Fu-Wen Liang, Wenyaw Chan, Ping-Jen Chen, Carissa Zimmerman, Stephen Waring, Rachelle Doody
INTRODUCTION: Some Alzheimer's disease (AD) patients die without ever developing cognitively impaired basic activities of daily living (basic ADL), which may reflect slower disease progression or better compensatory mechanisms. Although impaired basic ADL is related to disease severity, it may exert an independent risk for death. This study examined the association between impaired basic ADL and survival of AD patients, and proposed a multistate approach for modeling the time to death for patients who demonstrate different patterns of progression of AD that do or do not include basic ADL impairment...
2016: PloS One
https://www.readbyqxmd.com/read/27530844/an-institutional-review-of-antimicrobial-stewardship-interventions
#14
Henry Cao, Kady Phe, Gregory A Laine, Hannah R Russo, Kimberly S Putney, Vincent H Tam
In order to combat increasing rates of bacterial resistance, many institutions have implemented antimicrobial stewardship programmes (ASPs) to improve antibiotic use. To ascertain the potential impact of our stewardship programme at Baylor St Luke's Medical Center (Houston, TX), antimicrobial-related interventions were analysed over a 4-year period. ASP recommendations related to antimicrobial therapy from 2009 to 2012 were retrieved from the hospital electronic database and were retrospectively reviewed. The number of interventions for each time period was adjusted to the hospital census data...
September 2016: Journal of Global Antimicrobial Resistance
https://www.readbyqxmd.com/read/27521047/routine-central-lymph-node-dissection-with-total-thyroidectomy-for-papillary-thyroid-cancer-potentially-minimizes-level-vi-recurrence
#15
Chad M Hall, Samuel K Snyder, Yolanda Muñoz Maldonado, Terry C Lairmore
BACKGROUND: Treatment strategies for papillary thyroid cancer remain controversial due to the lack of large, randomized controlled trials. The purpose of this study was to review the benefit of routine bilateral central lymph node dissection (CLND) by analyzing local recurrence and complication rates from a single institution over a 15-year period. METHODS: A retrospective, institutional review board-approved review of the Baylor Scott & White Tumor Registry was performed on all patients who underwent operation for papillary thyroid cancer between 2000 and 2015...
October 2016: Surgery
https://www.readbyqxmd.com/read/27507541/starting-a-new-residency-program-a-step-by-step-guide-for-institutions-hospitals-and-program-directors
#16
Michelle Barajaz, Teri Turner
Although our country faces a looming shortage of doctors, constraints of space, funding, and patient volume in many existing residency programs limit training opportunities for medical graduates. New residency programs need to be created for the expansion of graduate medical education training positions. Partnerships between existing academic institutions and community hospitals with a need for physicians can be a very successful means toward this end. Baylor College of Medicine and The Children's Hospital of San Antonio were affiliated in 2012, and subsequently, we developed and received accreditation for a new categorical pediatric residency program at that site in 2014...
2016: Medical Education Online
https://www.readbyqxmd.com/read/27468762/use-of-relational-agents-to-improve-family-communication-in-type-1-diabetes-methods
#17
Debbe Thompson, Karen W Cullen, Maria J Redondo, Barbara Anderson
BACKGROUND: Physiological and environmental risk factors interact to undermine blood glucose control during early adolescence. This has been documented to be associated with family conflict and poor adherence to diabetes management tasks. Family Teamwork is an efficacious program demonstrated to enhance family communication and reduce conflict during this vulnerable period. It was designed to be delivered to families in-person, which limited reach and potential impact. OBJECTIVE: The purpose of this paper is to present the protocol for adapting Family Teamwork for Web-based delivery...
2016: JMIR Research Protocols
https://www.readbyqxmd.com/read/27442853/variables-associated-with-communicative-participation-after-head-and-neck-cancer
#18
Susan Bolt, Tanya Eadie, Kathryn Yorkston, Carolyn Baylor, Dagmar Amtmann
Importance: For patients with head and neck cancer (HNC), communication difficulties often create substantial barriers in daily life, affecting a person's ability to return to work, establish or maintain relationships, or participate in everyday activities. Objective: To examine variables significantly associated with communication in everyday activities, or communicative participation, in adult survivors of HNC. Design, Setting, and Participants: In a cross-sectional study, from November 1, 2008, through March 18, 2011, participants completed questionnaires about specific experiences and symptoms associated with their health and communication...
July 21, 2016: JAMA Otolaryngology—Head & Neck Surgery
https://www.readbyqxmd.com/read/27435318/exome-sequencing-in-mostly-consanguineous-arab-families-with-neurologic-disease-provides-a-high-potential-molecular-diagnosis-rate
#19
Wu-Lin Charng, Ender Karaca, Zeynep Coban Akdemir, Tomasz Gambin, Mehmed M Atik, Shen Gu, Jennifer E Posey, Shalini N Jhangiani, Donna M Muzny, Harsha Doddapaneni, Jianhong Hu, Eric Boerwinkle, Richard A Gibbs, Jill A Rosenfeld, Hong Cui, Fan Xia, Kandamurugu Manickam, Yaping Yang, Eissa A Faqeih, Ali Al Asmari, Mohammed A M Saleh, Ayman W El-Hattab, James R Lupski
BACKGROUND: Neurodevelopment is orchestrated by a wide range of genes, and the genetic causes of neurodevelopmental disorders are thus heterogeneous. We applied whole exome sequencing (WES) for molecular diagnosis and in silico analysis to identify novel disease gene candidates in a cohort from Saudi Arabia with primarily Mendelian neurologic diseases. METHODS: We performed WES in 31 mostly consanguineous Arab families and analyzed both single nucleotide and copy number variants (CNVs) from WES data...
2016: BMC Medical Genomics
https://www.readbyqxmd.com/read/27412853/the-ethics-of-conducting-molecular-autopsies-in-cases-of-sudden-death-in-the-young
#20
Amy L McGuire, Quianta Moore, Mary Majumder, Magdalena Walkiewicz, Christine M Eng, John W Belmont, Salma Nassef, Sandra Darilek, Katie Rutherford, Stacey Pereira, Steven E Scherer, V Reid Sutton, Dwayne Wolf, Richard A Gibbs, Roger Kahn, Luis A Sanchez
No abstract text is available yet for this article.
September 2016: Genome Research
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