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Brian I Rini, Arnulf Stenzl, Romauld Zdrojowy, Mikhail Kogan, Mikhail Shkolnik, Stephane Oudard, Steffen Weikert, Sergio Bracarda, Simon J Crabb, Jens Bedke, Joerg Ludwig, Dominik Maurer, Regina Mendrzyk, Claudia Wagner, Andrea Mahr, Jens Fritsche, Toni Weinschenk, Steffen Walter, Alexandra Kirner, Harpreet Singh-Jasuja, Carsten Reinhardt, Tim Eisen
BACKGROUND: In a phase 2 study in patients with metastatic renal cell carcinoma, overall survival was associated with T-cell responses against IMA901, a vaccine consisting of ten tumour-associated peptides. In this phase 3 trial, we aimed to determine the clinical effect of adding IMA901 to sunitinib, the standard first-line treatment in metastatic renal cell carcinoma with postulated favourable immunomodulatory effects. METHODS: The IMPRINT study is an open-label, randomised, controlled, phase 3 trial done at 124 clinical sites in 11 countries...
October 3, 2016: Lancet Oncology
J Menzel, R Di Giuseppe, R Biemann, K Aleksandrova, O Kuxhaus, C Wittenbecher, A Fritsche, M B Schulze, B Isermann, H Boeing, C Weikert
PURPOSE: Several studies implicated a crosstalk between bone and fat in the pathogenesis of osteoporosis. Few studies indicated an association between adiponectin and omentin-1 on the bone remodeling process and bone mineral density, and suggested osteoprotegerin (OPG) as a mediator of this relationship. However, only limited evidence on this relationship is available in humans. Therefore, this study aimed to investigate the association between omentin-1, adiponectin and broadband ultrasound attenuation (BUA) in peri-/premenopausal and postmenopausal women, and to assess the role of OPG as a possible mediator...
November 2016: Journal of Endocrinological Investigation
Philipp P Caffier, Ahmed I Nasr, Sebastian Weikert, Julius Rummich, Manfred Gross, Tadeus Nawka
OBJECTIVES/HYPOTHESIS: To evaluate the efficacy of vocal fold (VF) augmentation with calcium hydroxylapatite (CaHA) microspheres in the surgically pretreated larynx with glottal insufficiency. STUDY DESIGN: Prospective clinical pilot study. METHODS: After several prior reconstructive attempts (following tumor resection, VF paralysis, in sulcus vocalis, and VF scarring), CaHA was injected under general anaesthesia using a transoral microlaryngoscopic approach in 10 patients with residual glottal insufficiency ≤1...
August 31, 2016: Laryngoscope
Uta Wegewitz, Beate Weikert, Alba Fishta, Anja Jacobs, Dawid Pieper
BACKGROUND: Evidence syntheses, and in particular systematic reviews (SRs), have become one of the cornerstones of evidence-based health care. The Assessment of Multiple Systematic Reviews (AMSTAR) tool has become the most widely used tool for investigating the methodological quality of SRs and is currently undergoing revision. The objective of this paper is to present insights, challenges and potential solutions from the point of view of a group of assessors, while referring to earlier methodological discussions and debates with respect to AMSTAR...
2016: BMC Medical Research Methodology
J Wirth, R di Giuseppe, H Boeing, C Weikert
BACKGROUND/OBJECTIVES: Growing evidence emerged about the role of diet in heart failure (HF) development, but data are sparse and inconclusive. We examined the association between a Mediterranean-style diet, its components and HF risk. SUBJECTS/METHODS: Analyses were carried out in 24 008 middle-aged participants of the European Prospective Investigation into Cancer and Nutrition (EPIC)-Potsdam (Germany), including 209 incident HF cases within 8.2 years. The traditional Greek Mediterranean diet score (tMED) was used to assess dietary adherence...
September 2016: European Journal of Clinical Nutrition
J P Mills, M B Wilck, B C Weikert, P M Porrett, D Timko, K Alby, R A Bonomo, E A Blumberg
Donor-derived infections with multidrug-resistant gram-negative bacteria are associated with poor outcomes, in part because of limited treatment options. Here, we describe a case of donor-derived, disseminated infection with colistin-resistant, carbapenemase-producing Klebsiella pneumoniae in a liver transplant recipient that was cured with addition of intravenous fosfomycin to a multidrug regimen, in conjunction with aggressive surgical source control. Intravenous fosfomycin represents a promising adjunctive agent for use in treatment of extensively drug-resistant infections in immunocompromised hosts...
October 2016: Transplant Infectious Disease: An Official Journal of the Transplantation Society
Ronald Biemann, Marina Penner, Katrin Borucki, Sabine Westphal, Claus Luley, Raik Rönicke, Kathleen Biemann, Cornelia Weikert, Anke Lux, Nikolai Goncharenko, Hanns-Ulrich Marschall, Jochen G Schneider, Berend Isermann
Bile acids (BAs) are increasingly recognised as metabolic regulators, potentially improving insulin sensitivity following bariatric surgery. However, physiological relevance of such observations remains unknown. Hence, we analysed serum BA composition and associated gut-derived hormone levels following lifestyle-induced weight loss in individuals with metabolic syndrome (MetS). 74 non-smoking men (45-55 yr) with MetS were randomised to a lifestyle-induced weight loss program (supervision via telemonitoring) or to a control arm...
2016: Scientific Reports
Jack X Ma, Maolong Tang, Li Wang, Mitchell P Weikert, David Huang, Douglas D Koch
PURPOSE: To evaluate the accuracy of the optical coherence tomography-based (OCT formula) and Barrett True K (True K) intraocular lens (IOL) calculation formulas in eyes with previous radial keratotomy (RK). METHODS: In 95 eyes of 65 patients, using the actual refraction following cataract surgery as target refraction, the predicted IOL power for each method was calculated. The IOL prediction error (PE) was obtained by subtracting the predicted IOL power from the implanted IOL power...
July 1, 2016: Investigative Ophthalmology & Visual Science
Cornelia Weikert, Matthias B Schulze
PURPOSE OF THE REVIEW: The purpose of review is to present methodological issues as well as most relevant recent developments on the application of a statistical method to derive dietary patterns: reduced rank regression (RRR). RRR can be used efficiently in nutritional epidemiology to identify dietary patterns associated with selected response variables that have known relations with a disease outcome of interest. This has the advantage of building on a priori knowledge of biological relations, by including plausible intermediates between diet and the outcome of interest...
July 6, 2016: Current Opinion in Clinical Nutrition and Metabolic Care
Romina di Giuseppe, Ronald Biemann, Janine Wirth, Juliane Menzel, Berend Isermann, Gabriele I Stangl, Andreas Fritsche, Heiner Boeing, Matthias B Schulze, Cornelia Weikert
Heart failure (HF) is a disabling condition involving complex vascular, neurohormonal and immune systems' interactions. Osteoprotegerin (OPG), a bone-regulatory cytokine, has been suggested to play a key role in skeletal, vascular, and immune biology, with elevated levels observed in both experimental and clinical HF. In the present study we aimed to identify clinical OPG correlates and investigated whether elevated OPG, as a marker of HF vascular and immune activation, may interact with N-terminal pro-brain natriuretic peptide (NT-proBNP), a marker of HF neurohormonal activation, thus synergistically increasing HF risk...
June 15, 2016: European Journal of Epidemiology
Juliane Menzel, Romina di Giuseppe, Ronald Biemann, Clemens Wittenbecher, Krasimira Aleksandrova, Tobias Pischon, Andreas Fritsche, Matthias B Schulze, Heiner Boeing, Berend Isermann, Cornelia Weikert
BACKGROUND AND AIMS: The recently identified adipokine omentin-1 is inversely associated with body fatness, metabolic syndrome and cardiovascular disease (CVD) in cross-sectional analyses. However, prospective data on the association between plasma omentin-1 levels and future risk of CVD are lacking. The aim of the study was to investigate the relationship between omentin-1 and incident myocardial infarction (MI) and stroke. METHODS: We conducted a case-cohort study nested within the European Prospective Investigation into Cancer and Nutrition (EPIC)-Potsdam cohort comprising a subsample of 2084 participants, including 50 CVD cases and 350 external incident CVD cases (mean follow-up of 8...
August 2016: Atherosclerosis
David C Muller, Neil Murphy, Mattias Johansson, Pietro Ferrari, Konstantinos K Tsilidis, Marie-Christine Boutron-Ruault, Francoise Clavel, Laureen Dartois, Kuanrong Li, Rudolf Kaaks, Cornelia Weikert, Manuela Bergmann, Heiner Boeing, Anne Tjønneland, Kim Overvad, M Luisa Redondo, Antonio Agudo, Elena Molina-Portillo, Jone M Altzibar, Lluís Cirera, Eva Ardanaz, Kay-Tee Khaw, Nicholas J Wareham, Timothy J Key, Ruth C Travis, Christina Bamia, Philippos Orfanos, Antonia Trichopoulou, Domenico Palli, Valeria Pala, Rosario Tumino, Paolo Vineis, Salvatore Panico, H Bas Bueno-de-Mesquita, W M Monique Verschuren, Ellen A Struijk, Petra H Peeters, Gunnar Engström, Olle Melander, Malin Sund, Elisabete Weiderpass, Guri Skeie, Eiliv Lund, Teresa Norat, Marc Gunter, Elio Riboli, Paul Brennan
BACKGROUND: Life expectancy is increasing in Europe, yet a substantial proportion of adults still die prematurely before the age of 70 years. We sought to estimate the joint and relative contributions of tobacco smoking, hypertension, obesity, physical inactivity, alcohol and poor diet towards risk of premature death. METHODS: We analysed data from 264,906 European adults from the EPIC prospective cohort study, aged between 40 and 70 years at the time of recruitment...
2016: BMC Medicine
Mohammed Rigi, Zaina Al-Mohtaseb, Mitchell P Weikert
No abstract text is available yet for this article.
2016: International Ophthalmology Clinics
Stefan Dietrich, Anna Floegel, Cornelia Weikert, Tobias Pischon, Heiner Boeing, Dagmar Drogan
Metabolomics is a promising tool to gain new insights into early metabolic alterations preceding the development of hypertension in humans. We therefore aimed to identify metabolites associated with incident hypertension using measured data of serum metabolites of the European Prospective Investigation Into Cancer and Nutrition (EPIC)-Potsdam study. Targeted metabolic profiling was conducted on serum blood samples of a randomly drawn EPIC-Potsdam subcohort consisting of 135 cases and 981 noncases of incident hypertension, all of them being free of hypertension and not on antihypertensive therapy at the time of blood sampling...
August 2016: Hypertension
Krasimira Aleksandrova, Romina di Giuseppe, Berend Isermann, Ronald Biemann, Matthias Schulze, Clemens Wittenbecher, Andreas Fritsche, Rainer Lehmann, Juliane Menzel, Cornelia Weikert, Tobias Pischon, Heiner Boeing
Omentin is a novel biomarker shown to exert metabolic, inflammatory, and immune-related properties and thereby could be implicated in the risk of colorectal cancer. So far, the association between omentin and colorectal cancer risk has not been evaluated in prospective cohort studies. We investigated the association between prediagnostic plasma omentin concentrations and risk of colorectal cancer in a case-cohort comprising 251 incident colorectal cancer cases diagnosed over a mean follow-up time of 10.4 years and 2,295 persons who remained free of cancer in the European Prospective Investigation into Cancer and Nutrition-Potsdam study...
July 1, 2016: Cancer Research
Ildamaris Montes de Oca, Eric J Kim, Li Wang, Mitchell P Weikert, Sumitra S Khandelwal, Zaina Al-Mohtaseb, Douglas D Koch
PURPOSE: To evaluate the accuracy of toric intraocular lens (IOL) alignment in femtosecond laser-assisted cataract surgery using the Truevision 3-dimensional (3-D) computer-guided visualization system compared with a manual marking method. SETTING: Cullen Eye Institute, Baylor College of Medicine, Houston, Texas, USA. DESIGN: Retrospective comparative case series. METHODS: Preoperatively, all patients had corneal topography measurements with a color light-emitting diode topographer...
April 2016: Journal of Cataract and Refractive Surgery
Tatjana Salmen, Tatiana Ermakova, Andreas Möller, Matthias Seipelt, Sebastian Weikert, Julius Rummich, Manfred Gross, Tadeus Nawka, Philipp P Caffier
OBJECTIVE: This study aimed to present vocal extent measure (VEM), demonstrate its changes with phonomicrosurgical treatment in patients with vocal fold polyps (VFPs), and to compare its performance to that of established vocal parameters. STUDY DESIGN: This is an individual cohort study. METHODS: Microlaryngoscopic ablation was executed in 61 patients with manifestation of VFP (28 male, 33 female; 45 ± 13 years [mean ± SD]). Analysis of treatment outcome was based on pre- and postoperative voice function diagnostics and videolaryngostroboscopy...
April 21, 2016: Journal of Voice: Official Journal of the Voice Foundation
Florian Bast, Susann Roos, Sebastian Weikert, Thomas Schrom
A variety of flaps are available to cover skin defects after surgery or trauma in the head and neck area. The bilobed flap is a double transposition flap commonly used in reconstruction of small-to-medium skin defects of the face where skin is less mobile. However, larger defects can also be effectively treated with a bilobed flap in certain cases. The classic indication to cover a small defect on the nose and covering a large skin-defect after tumour resection in the jugular notch. After sufficient mobilization, the defects could easily be closed with no wound complications and with very good aesthetic and functional outcome...
March 2016: Journal of the College of Physicians and Surgeons—Pakistan: JCPSP
Cory L Simpson, Soren Craig-Muller, Joseph F Sobanko, Blair C Weikert, Robert G Micheletti
No abstract text is available yet for this article.
March 2016: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
Saira Bhatti, Evelyn A Paysse, Mitch P Weikert, Lingkun Kong
PURPOSE: We conducted a cross-sectional study to test the hypothesis that the structural contributions to myopia in preterm and full-term born children are different. METHODS: In this study, 93 children ranging from ages 2 to 13 who had myopia ≥ -3 diopters in at least one eye were examined with A-scans. The following data was collected and analyzed: history of birth, refractive error (RE), cornea thickness (CT) and average corneal curvature (AVK), depth of anterior chamber (ACD), lens thickness (LT), and axial length (AL) of the eye...
May 2016: Graefe's Archive for Clinical and Experimental Ophthalmology
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