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https://www.readbyqxmd.com/read/29096426/results-and-evaluation-of-a-first-in-human-study-of-rg7342-a-mglu5-positive-allosteric-modulator-utilizing-bayesian-adaptive-methods
#1
Stefan Sturm, Marie-Laure Delporte, Salah Hadi, Scott Schobel, Lothar Lindemann, Robert Weikert, Georg Jaeschke, Michael Derks, Giuseppe Palermo
AIM: The objectives of this first-in-human study were to evaluate the safety and tolerability, pharmacokinetics and pharmacodynamics, and to determine the maximum tolerated dose (MTD) of single ascending oral doses of RG7342, a positive allosteric modulator (PAM) of the metabotropic glutamate receptor 5 (mGlu5) for the treatment of schizophrenia, in healthy male subjects. METHODS: This was a single-centre, randomized, double-blind, adaptive study of 37 subjects receiving single ascending oral doses of RG7342 (ranging from 0...
November 2, 2017: British Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/29075000/association-between-chemerin-omentin-1-and-risk-of-heart-failure-in-the-population-based-epic-potsdam-study
#2
Juliane Menzel, Romina di Giuseppe, Ronald Biemann, Clemens Wittenbecher, Krasimira Aleksandrova, Fabian Eichelmann, Andreas Fritsche, Matthias B Schulze, Heiner Boeing, Berend Isermann, Cornelia Weikert
The adipokines chemerin and omentin-1 have been suggested to influence cardiovascular function. The study aimed to investigate the longitudinal association between chemerin, omentin-1 concentrations and risk of incident heart failure (HF), respectively. We conducted a case-cohort study nested within the European Prospective Investigation into Cancer and Nutrition (EPIC)-Potsdam cohort (n = 27548) including a randomly drawn subsample and all incident HF cases during a mean follow-up of 8.2 ± 1.5 years...
October 26, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28980107/determinants-of-sickness-absence-and-return-to-work-among-employees-with-common-mental-disorders-a-scoping-review
#3
REVIEW
Haitze de Vries, Alba Fishta, Beate Weikert, Alejandra Rodriguez Sanchez, Uta Wegewitz
Purpose To present an overview of the existing evidence on prognostic factors of (recurrent) sickness absence (SA) and return to work (RTW) among workers with a common mental disorder (CMD). This scoping review provides information about determinants for SA and RTW, which could be used to develop better interventions aimed at the prevention of SA and promotion of RTW among workers with a CMD. Methods Relevant articles were identified in PubMed, Embase, PsycINFO, PSYNDEX, and SINGLE up to October 2016. In order to be included, studies should provide insight into prognostic factors of SA or RTW of workers with a CMD...
October 4, 2017: Journal of Occupational Rehabilitation
https://www.readbyqxmd.com/read/28933187/headless-screw-fixation-of-metacarpal-neck-fractures-a-mechanical-comparative-analysis
#4
Christopher M Jones, Eric M Padegimas, Nicole Weikert, Samuel Greulich, Asif M Ilyas, Sorin Siegler
BACKGROUND: The purpose of this study was to compare the mechanical properties of metacarpal neck fracture fixation by headless compression screw (HCS) with that of Kirschner wire (KW) cross-pinning and locking plate (LP) fixation. METHODS: A metacarpal neck fracture was created in 30 fourth-generation composite Sawbones metacarpal models. A volar-based wedge was removed using a custom jig to simulate a typical apex dorsal fracture, unstable in flexion. The models were divided into 3 equal groups based on the method of fixation: retrograde cross-pinning with two 1...
September 1, 2017: Hand: Official Journal of the American Association for Hand Surgery
https://www.readbyqxmd.com/read/28923499/descemet-membrane-endothelial-keratoplasty-safety-and-outcomes-a-report-by-the-american-academy-of-ophthalmology
#5
Sophie X Deng, W Barry Lee, Kristin M Hammersmith, Anthony N Kuo, Jennifer Y Li, Joanne F Shen, Mitchell P Weikert, Roni M Shtein
PURPOSE: To review the published literature on the safety and outcomes of Descemet membrane endothelial keratoplasty (DMEK) for the surgical treatment of corneal endothelial dysfunction. METHODS: Literature searches were last conducted in the PubMed and the Cochrane Library databases most recently in May 2017. The searches, which were limited to English-language abstracts, yielded 1085 articles. The panel reviewed the abstracts, and 47 were determined to be relevant to this assessment...
September 15, 2017: Ophthalmology
https://www.readbyqxmd.com/read/28917418/august-consultation-2
#6
Mitchell P Weikert
No abstract text is available yet for this article.
August 2017: Journal of Cataract and Refractive Surgery
https://www.readbyqxmd.com/read/28732609/refractive-outcomes-after-multifocal-intraocular-lens-exchange
#7
Eric J Kim, Ahmar Sajjad, Ildamaris Montes de Oca, Douglas D Koch, Li Wang, Mitchell P Weikert, Zaina N Al-Mohtaseb
PURPOSE: To evaluate the refractive outcomes after multifocal intraocular lens (IOL) exchange. SETTING: Cullen Eye Institute, Baylor College of Medicine, Houston, Texas, USA. DESIGN: Retrospective case series. METHODS: Patients had multifocal IOL explantation followed by IOL implantation. Outcome measures included type of IOL, surgical indication, corrected distance visual acuity (CDVA), and refractive prediction error...
June 2017: Journal of Cataract and Refractive Surgery
https://www.readbyqxmd.com/read/28693497/inter-rater-reliability-of-amstar-is-dependent-on-the-pair-of-reviewers
#8
Dawid Pieper, Anja Jacobs, Beate Weikert, Alba Fishta, Uta Wegewitz
BACKGROUND: Inter-rater reliability (IRR) is mainly assessed based on only two reviewers of unknown expertise. The aim of this paper is to examine differences in the IRR of the Assessment of Multiple Systematic Reviews (AMSTAR) and R(evised)-AMSTAR depending on the pair of reviewers. METHODS: Five reviewers independently applied AMSTAR and R-AMSTAR to 16 systematic reviews (eight Cochrane reviews and eight non-Cochrane reviews) from the field of occupational health...
July 11, 2017: BMC Medical Research Methodology
https://www.readbyqxmd.com/read/28592510/methodological-utility-of-chemerin-as-a-novel-biomarker-of-immunity-and-metabolism
#9
Fabian Eichelmann, Cornelia Weikert, Romina di Giuseppe, Ronald Biemann, Berend Isermann, Matthias B Schulze, Heiner Boeing, Krasimira Aleksandrova
Chemerin is a recently discovered adipokine with inflammatory and metabolic actions relevant for chronic disease development. However, evidence from human research on the role of chemerin in chronic disease risk is still lacking. We assessed the reliability of plasma chemerin concentrations measured on two occasions over a 4-month period in 207 apparently healthy participants. In addition, we explored the cross-sectional associations between chemerin and inflammatory biomarkers using Spearman partial correlation and multivariable linear regression analyses...
July 2017: Endocrine Connections
https://www.readbyqxmd.com/read/28590285/updates-in-biometry
#10
Rodrigo Guimarães de Souza, Ildamaris Montes de Oca, Isi Esquenazi, Zaina Al-Mohtaseb, Mitchell P Weikert
No abstract text is available yet for this article.
2017: International Ophthalmology Clinics
https://www.readbyqxmd.com/read/28590283/perioperative-imaging-in-corneal-surgery-intraoperative-and-postoperative
#11
Kourtney Houser, Mitchell Weikert, Zaina Al-Mohtaseb
No abstract text is available yet for this article.
2017: International Ophthalmology Clinics
https://www.readbyqxmd.com/read/28590281/new-diagnostics-in-corneal-ectatic-disease
#12
Joshua K Duncan, Isi Esquenazi, Mitchell P Weikert
No abstract text is available yet for this article.
2017: International Ophthalmology Clinics
https://www.readbyqxmd.com/read/28590276/preface-state-of-the-art-and-beyond-anterior-segment-diagnostics
#13
Zaina Nabil Al-Mohtaseb, Mitchell Weikert
No abstract text is available yet for this article.
2017: International Ophthalmology Clinics
https://www.readbyqxmd.com/read/28410720/secondary-intraocular-lens-implantation-complication-rates-visual-acuity-and-refractive-outcomes
#14
Greg Brunin, Ahmar Sajjad, Eric J Kim, Ildamaris Montes de Oca, Mitchell P Weikert, Li Wang, Douglas D Koch, Zaina Al-Mohtaseb
PURPOSE: To compare complication rates, visual acuity, and refractive outcomes of secondary intraocular lens (IOLs) implantation. SETTING: Department of Ophthalmology, Cullen Eye Institute, Baylor College of Medicine, Houston, Texas, USA. DESIGN: Retrospective case series. METHODS: All secondary IOLs placed by the anterior segment service were reviewed. Preoperative data, operative reports, and data from each subsequent postoperative visit were evaluated...
March 2017: Journal of Cataract and Refractive Surgery
https://www.readbyqxmd.com/read/28351470/in-reply
#15
Christian Doehn, Steffen Weikert
No abstract text is available yet for this article.
March 3, 2017: Deutsches Ärzteblatt International
https://www.readbyqxmd.com/read/28317681/comparison-of-biometry-and-intraocular-lens-power-calculation-performed-by-a-new-optical-biometry-device-and-a-reference-biometer
#16
Bruna V Ventura, Marcelo C Ventura, Li Wang, Douglas D Koch, Mitchell P Weikert
PURPOSE: To compare biometry measurements and intraocular lens (IOL) power calculations obtained by a new optical A-scan interferometer biometer (Galilei G6) (new biometer) and a partial coherence interferometer biometer (IOLMaster 500) (reference biometer). SETTING: Private practice, Recife, Brazil. DESIGN: Retrospective comparative study. METHODS: Cataract patients who had biometric measurements with the new biometer and the reference biometer were included in the study...
January 2017: Journal of Cataract and Refractive Surgery
https://www.readbyqxmd.com/read/28137672/multiple-imputation-was-a-valid-approach-to-estimate-absolute-risk-from-a-prediction-model-based-on-case-cohort-data
#17
Kristin Mühlenbruch, Olga Kuxhaus, Romina di Giuseppe, Heiner Boeing, Cornelia Weikert, Matthias B Schulze
OBJECTIVE: To compare weighting methods for Cox regression and multiple imputation (MI) in a case-cohort study in the context of risk prediction modeling. STUDY DESIGN AND SETTING: Based on the European Prospective Investigation into Cancer and Nutrition Potsdam study, we estimated risk scores to predict incident type-2 diabetes using full cohort data and case-cohort data assuming missing information on waist circumference outside the case-cohort (∼90%). Varying weighting approaches and MI were compared with regard to the calculation of relative risks, absolute risks, and predictive abilities including C-index, the net reclassification improvement, and calibration...
April 2017: Journal of Clinical Epidemiology
https://www.readbyqxmd.com/read/28073425/hypertension-in-germany
#18
Hannelore Neuhauser, Claudia Diederichs, Heiner Boeing, Stephan B Felix, Claus Jünger, Roberto Lorbeer, Christine Meisinger, Annette Peters, Henry Völzke, Cornelia Weikert, Philipp Wild, Marcus Dörr
BACKGROUND: Hypertension is a key risk factor. However, population data based on blood pressure measurements in Germany are scarce. METHODS: Standardized blood pressure (BP) measurements and medication data from seven population-based studies conducted in Germany between 1994 and 2012 (66 845 participants, 25-74 years) were analyzed: the EPICPotsdam study (1994-1998, EPIC), the KORA-S4 Study (1999-2001) in Augsburg, and the Gutenberg Health Study (2007-2012, GHS) in Mainz/Mainz-Bingen provided data for descriptive comparisons...
December 2, 2016: Deutsches Ärzteblatt International
https://www.readbyqxmd.com/read/27863829/the-effect-of-carpal-tunnel-release-on-typing-performance
#19
Justin W Zumsteg, Matthew J C Crump, Gordon D Logan, Douglas R Weikert, Donald H Lee
PURPOSE: To describe the effect of carpal tunnel release (CTR) on typing performance. METHODS: We prospectively studied 27 patients undergoing open CTR. Patient demographics and clinical characteristics including nerve conduction studies, electromyography results, and duration of symptoms were collected. Before surgery and at 8 time points after surgery, ranging from 1 to 12 weeks, typing performance for an approximately 500-character paragraph was assessed via an on-line platform...
January 2017: Journal of Hand Surgery
https://www.readbyqxmd.com/read/27808407/extension-of-the-clinical-and-molecular-phenotype-of-diaph1-associated-autosomal-dominant-hearing-loss-dfna1
#20
C Neuhaus, R Lang-Roth, U Zimmermann, R Heller, T Eisenberger, M Weikert, S Markus, M Knipper, H J Bolz
In about 20% of non-syndromic hearing loss (NSHL) cases, inheritance is autosomal dominant (ADNSHL). DIAPH1 mutations define the ADNSHL locus DFNA1. We identified two new families with heterozygous truncating DIAPH1 mutations (p.Ala1210Serfs*31 and p.Arg1213*). In contrast to the extensively studied original DFNA1 family, hearing loss was not confined to low frequencies, but congenital manifestation and rapid progression were confirmed. In line with a recent unrelated study, we identified an association with thrombocytopenia, reclassifying DFNA1 as a syndrome...
June 2017: Clinical Genetics
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