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https://www.readbyqxmd.com/read/28592510/methodological-utility-of-chemerin-as-a-novel-biomarker-of-immunity-and-metabolism
#1
Fabian Eichelmann, Cornelia Weikert, Romina di Giuseppe, Ronald Biemann, Berend Isermann, M B Schulze, Heiner Boeing, Krasimira Aleksandrova
Chemerin is a recently discovered adipokine with inflammatory and metabolic actions relevant for chronic disease development. However, evidence from human research on the role of chemerin in chronic disease risk is still lacking. We assessed reliability of plasma chemerin concentrations measured on two occasions over a 4-month period in 207 apparently healthy participants. In addition, we explored cross-sectional associations between chemerin and inflammatory biomarkers using Spearman partial correlation and multivariable linear regression analyses...
June 7, 2017: Endocrine Connections
https://www.readbyqxmd.com/read/28590285/updates-in-biometry
#2
Rodrigo Guimarães de Souza, Ildamaris Montes de Oca, Isi Esquenazi, Zaina Al-Mohtaseb, Mitchell P Weikert
No abstract text is available yet for this article.
2017: International Ophthalmology Clinics
https://www.readbyqxmd.com/read/28590283/perioperative-imaging-in-corneal-surgery-intraoperative-and-postoperative
#3
Kourtney Houser, Mitchell Weikert, Zaina Al-Mohtaseb
No abstract text is available yet for this article.
2017: International Ophthalmology Clinics
https://www.readbyqxmd.com/read/28590281/new-diagnostics-in-corneal-ectatic-disease
#4
Joshua K Duncan, Isi Esquenazi, Mitchell P Weikert
No abstract text is available yet for this article.
2017: International Ophthalmology Clinics
https://www.readbyqxmd.com/read/28590276/preface-state-of-the-art-and-beyond-anterior-segment-diagnostics
#5
Zaina Nabil Al-Mohtaseb, Mitchell Weikert
No abstract text is available yet for this article.
2017: International Ophthalmology Clinics
https://www.readbyqxmd.com/read/28410720/secondary-intraocular-lens-implantation-complication-rates-visual-acuity-and-refractive-outcomes
#6
Greg Brunin, Ahmar Sajjad, Eric J Kim, Ildamaris Montes de Oca, Mitchell P Weikert, Li Wang, Douglas D Koch, Zaina Al-Mohtaseb
PURPOSE: To compare complication rates, visual acuity, and refractive outcomes of secondary intraocular lens (IOLs) implantation. SETTING: Department of Ophthalmology, Cullen Eye Institute, Baylor College of Medicine, Houston, Texas, USA. DESIGN: Retrospective case series. METHODS: All secondary IOLs placed by the anterior segment service were reviewed. Preoperative data, operative reports, and data from each subsequent postoperative visit were evaluated...
March 2017: Journal of Cataract and Refractive Surgery
https://www.readbyqxmd.com/read/28351470/in-reply
#7
Christian Doehn, Steffen Weikert
No abstract text is available yet for this article.
March 3, 2017: Deutsches Ärzteblatt International
https://www.readbyqxmd.com/read/28317681/comparison-of-biometry-and-intraocular-lens-power-calculation-performed-by-a-new-optical-biometry-device-and-a-reference-biometer
#8
Bruna V Ventura, Marcelo C Ventura, Li Wang, Douglas D Koch, Mitchell P Weikert
PURPOSE: To compare biometry measurements and intraocular lens (IOL) power calculations obtained by a new optical A-scan interferometer biometer (Galilei G6) (new biometer) and a partial coherence interferometer biometer (IOLMaster 500) (reference biometer). SETTING: Private practice, Recife, Brazil. DESIGN: Retrospective comparative study. METHODS: Cataract patients who had biometric measurements with the new biometer and the reference biometer were included in the study...
January 2017: Journal of Cataract and Refractive Surgery
https://www.readbyqxmd.com/read/28137672/multiple-imputation-was-a-valid-approach-to-estimate-absolute-risk-from-a-prediction-model-based-on-case-cohort-data
#9
Kristin Mühlenbruch, Olga Kuxhaus, Romina di Giuseppe, Heiner Boeing, Cornelia Weikert, Matthias B Schulze
OBJECTIVE: To compare weighting methods for Cox regression and multiple imputation (MI) in a case-cohort study in the context of risk prediction modeling. STUDY DESIGN AND SETTING: Based on the European Prospective Investigation into Cancer and Nutrition Potsdam study, we estimated risk scores to predict incident type-2 diabetes using full cohort data and case-cohort data assuming missing information on waist circumference outside the case-cohort (∼90%). Varying weighting approaches and MI were compared with regard to the calculation of relative risks, absolute risks, and predictive abilities including C-index, the net reclassification improvement, and calibration...
January 28, 2017: Journal of Clinical Epidemiology
https://www.readbyqxmd.com/read/28073425/hypertension-in-germany
#10
Hannelore Neuhauser, Claudia Diederichs, Heiner Boeing, Stephan B Felix, Claus Jünger, Roberto Lorbeer, Christine Meisinger, Annette Peters, Henry Völzke, Cornelia Weikert, Philipp Wild, Marcus Dörr
BACKGROUND: Hypertension is a key risk factor. However, population data based on blood pressure measurements in Germany are scarce. METHODS: Standardized blood pressure (BP) measurements and medication data from seven population-based studies conducted in Germany between 1994 and 2012 (66 845 participants, 25-74 years) were analyzed: the EPICPotsdam study (1994-1998, EPIC), the KORA-S4 Study (1999-2001) in Augsburg, and the Gutenberg Health Study (2007-2012, GHS) in Mainz/Mainz-Bingen provided data for descriptive comparisons...
December 2, 2016: Deutsches Ärzteblatt International
https://www.readbyqxmd.com/read/27863829/the-effect-of-carpal-tunnel-release-on-typing-performance
#11
Justin W Zumsteg, Matthew J C Crump, Gordon D Logan, Douglas R Weikert, Donald H Lee
PURPOSE: To describe the effect of carpal tunnel release (CTR) on typing performance. METHODS: We prospectively studied 27 patients undergoing open CTR. Patient demographics and clinical characteristics including nerve conduction studies, electromyography results, and duration of symptoms were collected. Before surgery and at 8 time points after surgery, ranging from 1 to 12 weeks, typing performance for an approximately 500-character paragraph was assessed via an on-line platform...
January 2017: Journal of Hand Surgery
https://www.readbyqxmd.com/read/27808407/extension-of-the-clinical-and-molecular-phenotype-of-diaph1-associated-autosomal-dominant-hearing-loss-dfna1
#12
C Neuhaus, R Lang-Roth, U Zimmermann, R Heller, T Eisenberger, M Weikert, S Markus, M Knipper, H J Bolz
In about 20% of non-syndromic hearing loss (NSHL) cases, inheritance is autosomal dominant (ADNSHL). DIAPH1 mutations define the ADNSHL locus DFNA1. We identified two new families with heterozygous truncating DIAPH1 mutations (p.Ala1210Serfs*31 and p.Arg1213*). In contrast to the extensively studied original DFNA1 family, hearing loss was not confined to low frequencies, but congenital manifestation and rapid progression were confirmed. In line with a recent unrelated study, we identified an association with thrombocytopenia, reclassifying DFNA1 as a syndrome...
June 2017: Clinical Genetics
https://www.readbyqxmd.com/read/27798103/prostate-cancer-risk-regions-at-8q24-and-17q24-are-differentially-associated-with-somatic-tmprss2-erg-fusion-status
#13
Manuel Luedeke, Antje E Rinckleb, Liesel M FitzGerald, Milan S Geybels, Johanna Schleutker, Rosalind A Eeles, Manuel R Teixeira, Lisa Cannon-Albright, Elaine A Ostrander, Steffen Weikert, Kathleen Herkommer, Tiina Wahlfors, Tapio Visakorpi, Katri A Leinonen, Teuvo L J Tammela, Colin S Cooper, Zsofia Kote-Jarai, Sandra Edwards, Chee L Goh, Frank McCarthy, Chris Parker, Penny Flohr, Paula Paulo, Carmen Jerónimo, Rui Henrique, Hans Krause, Sven Wach, Verena Lieb, Tilman T Rau, Walther Vogel, Rainer Kuefer, Matthias D Hofer, Sven Perner, Mark A Rubin, Archana M Agarwal, Doug F Easton, Ali Amin Al Olama, Sara Benlloch, Josef Hoegel, Janet L Stanford, Christiane Maier
Molecular and epidemiological differences have been described between TMPRSS2:ERG fusion-positive and fusion-negative prostate cancer (PrCa). Assuming two molecularly distinct subtypes, we have examined 27 common PrCa risk variants, previously identified in genome-wide association studies, for subtype specific associations in a total of 1221 TMPRSS2:ERG phenotyped PrCa cases. In meta-analyses of a discovery set of 552 cases with TMPRSS2:ERG data and 7650 unaffected men from five centers we have found support for the hypothesis that several common risk variants are associated with one particular subtype rather than with PrCa in general...
December 15, 2016: Human Molecular Genetics
https://www.readbyqxmd.com/read/27796501/higher-serum-asymmetric-dimethylarginine-is-related-to-higher-risk-of-heart-failure-in-the-epic-potsdam-study
#14
Janine Wirth, Dorothee Atzler, Romina di Giuseppe, Kathrin Cordts, Juliane Menzel, Rainer H Böger, Heiner Boeing, Cornelia Weikert, Edzard Schwedhelm
L-Arginine is the substrate of endothelial nitric oxide (NO) synthase forming NO which inherits various biological cardio-protective functions. The dimethylarginines asymmetric (ADMA) and symmetric dimethylarginine (SDMA) can impair the synthesis of NO and are elevated in patients with cardiovascular disease, including heart failure (HF). We investigated the association between dimethylarginines and HF risk in a case-cohort study of the European Prospective Investigation into Cancer and Nutrition (n = 27,548), comprising a random subcohort (n = 2224 including 19 HF cases), and all remaining HF cases (n = 176) that occurred within 8...
January 2017: Amino Acids
https://www.readbyqxmd.com/read/27720136/ima901-a-multipeptide-cancer-vaccine-plus-sunitinib-versus-sunitinib-alone-as-first-line-therapy-for-advanced-or-metastatic-renal-cell-carcinoma-imprint-a-multicentre-open-label-randomised-controlled-phase-3-trial
#15
RANDOMIZED CONTROLLED TRIAL
Brian I Rini, Arnulf Stenzl, Romauld Zdrojowy, Mikhail Kogan, Mikhail Shkolnik, Stephane Oudard, Steffen Weikert, Sergio Bracarda, Simon J Crabb, Jens Bedke, Joerg Ludwig, Dominik Maurer, Regina Mendrzyk, Claudia Wagner, Andrea Mahr, Jens Fritsche, Toni Weinschenk, Steffen Walter, Alexandra Kirner, Harpreet Singh-Jasuja, Carsten Reinhardt, Tim Eisen
BACKGROUND: In a phase 2 study in patients with metastatic renal cell carcinoma, overall survival was associated with T-cell responses against IMA901, a vaccine consisting of ten tumour-associated peptides. In this phase 3 trial, we aimed to determine the clinical effect of adding IMA901 to sunitinib, the standard first-line treatment in metastatic renal cell carcinoma with postulated favourable immunomodulatory effects. METHODS: The IMPRINT study is an open-label, randomised, controlled, phase 3 trial done at 124 clinical sites in 11 countries...
November 2016: Lancet Oncology
https://www.readbyqxmd.com/read/27614458/association-between-omentin-1-adiponectin-and-bone-health-under-consideration-of-osteoprotegerin-as-possible-mediator
#16
RANDOMIZED CONTROLLED TRIAL
J Menzel, R Di Giuseppe, R Biemann, K Aleksandrova, O Kuxhaus, C Wittenbecher, A Fritsche, M B Schulze, B Isermann, H Boeing, C Weikert
PURPOSE: Several studies implicated a crosstalk between bone and fat in the pathogenesis of osteoporosis. Few studies indicated an association between adiponectin and omentin-1 on the bone remodeling process and bone mineral density, and suggested osteoprotegerin (OPG) as a mediator of this relationship. However, only limited evidence on this relationship is available in humans. Therefore, this study aimed to investigate the association between omentin-1, adiponectin and broadband ultrasound attenuation (BUA) in peri-/premenopausal and postmenopausal women, and to assess the role of OPG as a possible mediator...
November 2016: Journal of Endocrinological Investigation
https://www.readbyqxmd.com/read/27578371/the-use-of-injectable-calcium-hydroxylapatite-in-the-surgically-pretreated-larynx-with-glottal-insufficiency
#17
Philipp P Caffier, Ahmed I Nasr, Sebastian Weikert, Julius Rummich, Manfred Gross, Tadeus Nawka
OBJECTIVES/HYPOTHESIS: To evaluate the efficacy of vocal fold (VF) augmentation with calcium hydroxylapatite (CaHA) microspheres in the surgically pretreated larynx with glottal insufficiency. STUDY DESIGN: Prospective clinical pilot study. METHODS: After several prior reconstructive attempts (following tumor resection, VF paralysis, in sulcus vocalis, and VF scarring), CaHA was injected under general anaesthesia using a transoral microlaryngoscopic approach in 10 patients with residual glottal insufficiency ≤1...
May 2017: Laryngoscope
https://www.readbyqxmd.com/read/27566440/resuming-the-discussion-of-amstar-what-can-should-be-made-better
#18
EDITORIAL
Uta Wegewitz, Beate Weikert, Alba Fishta, Anja Jacobs, Dawid Pieper
BACKGROUND: Evidence syntheses, and in particular systematic reviews (SRs), have become one of the cornerstones of evidence-based health care. The Assessment of Multiple Systematic Reviews (AMSTAR) tool has become the most widely used tool for investigating the methodological quality of SRs and is currently undergoing revision. The objective of this paper is to present insights, challenges and potential solutions from the point of view of a group of assessors, while referring to earlier methodological discussions and debates with respect to AMSTAR...
2016: BMC Medical Research Methodology
https://www.readbyqxmd.com/read/27507073/a-mediterranean-style-diet-its-components-and-the-risk-of-heart-failure-a-prospective-population-based-study-in-a-non-mediterranean-country
#19
J Wirth, R di Giuseppe, H Boeing, C Weikert
BACKGROUND/OBJECTIVES: Growing evidence emerged about the role of diet in heart failure (HF) development, but data are sparse and inconclusive. We examined the association between a Mediterranean-style diet, its components and HF risk. SUBJECTS/METHODS: Analyses were carried out in 24 008 middle-aged participants of the European Prospective Investigation into Cancer and Nutrition (EPIC)-Potsdam (Germany), including 209 incident HF cases within 8.2 years. The traditional Greek Mediterranean diet score (tMED) was used to assess dietary adherence...
September 2016: European Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/27458980/successful-treatment-of-a-disseminated-infection-with-extensively-drug-resistant-klebsiella-pneumoniae-in-a-liver-transplant-recipient-with-a-fosfomycin-based-multidrug-regimen
#20
J P Mills, M B Wilck, B C Weikert, P M Porrett, D Timko, K Alby, R A Bonomo, E A Blumberg
Donor-derived infections with multidrug-resistant gram-negative bacteria are associated with poor outcomes, in part because of limited treatment options. Here, we describe a case of donor-derived, disseminated infection with colistin-resistant, carbapenemase-producing Klebsiella pneumoniae in a liver transplant recipient that was cured with addition of intravenous fosfomycin to a multidrug regimen, in conjunction with aggressive surgical source control. Intravenous fosfomycin represents a promising adjunctive agent for use in treatment of extensively drug-resistant infections in immunocompromised hosts...
October 2016: Transplant Infectious Disease: An Official Journal of the Transplantation Society
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