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https://www.readbyqxmd.com/read/28933187/headless-screw-fixation-of-metacarpal-neck-fractures-a-mechanical-comparative-analysis
#1
Christopher M Jones, Eric M Padegimas, Nicole Weikert, Samuel Greulich, Asif M Ilyas, Sorin Siegler
BACKGROUND: The purpose of this study was to compare the mechanical properties of metacarpal neck fracture fixation by headless compression screw (HCS) with that of Kirschner wire (KW) cross-pinning and locking plate (LP) fixation. METHODS: A metacarpal neck fracture was created in 30 fourth-generation composite Sawbones metacarpal models. A volar-based wedge was removed using a custom jig to simulate a typical apex dorsal fracture, unstable in flexion. The models were divided into 3 equal groups based on the method of fixation: retrograde cross-pinning with two 1...
September 1, 2017: Hand: Official Journal of the American Association for Hand Surgery
https://www.readbyqxmd.com/read/28923499/descemet-membrane-endothelial-keratoplasty-safety-and-outcomes-a-report-by-the-american-academy-of-ophthalmology
#2
Sophie X Deng, W Barry Lee, Kristin M Hammersmith, Anthony N Kuo, Jennifer Y Li, Joanne F Shen, Mitchell P Weikert, Roni M Shtein
PURPOSE: To review the published literature on the safety and outcomes of Descemet membrane endothelial keratoplasty (DMEK) for the surgical treatment of corneal endothelial dysfunction. METHODS: Literature searches were last conducted in the PubMed and the Cochrane Library databases most recently in May 2017. The searches, which were limited to English-language abstracts, yielded 1085 articles. The panel reviewed the abstracts, and 47 were determined to be relevant to this assessment...
September 15, 2017: Ophthalmology
https://www.readbyqxmd.com/read/28917418/august-consultation-2
#3
Mitchell P Weikert
No abstract text is available yet for this article.
August 2017: Journal of Cataract and Refractive Surgery
https://www.readbyqxmd.com/read/28732609/refractive-outcomes-after-multifocal-intraocular-lens-exchange
#4
Eric J Kim, Ahmar Sajjad, Ildamaris Montes de Oca, Douglas D Koch, Li Wang, Mitchell P Weikert, Zaina N Al-Mohtaseb
PURPOSE: To evaluate the refractive outcomes after multifocal intraocular lens (IOL) exchange. SETTING: Cullen Eye Institute, Baylor College of Medicine, Houston, Texas, USA. DESIGN: Retrospective case series. METHODS: Patients had multifocal IOL explantation followed by IOL implantation. Outcome measures included type of IOL, surgical indication, corrected distance visual acuity (CDVA), and refractive prediction error...
June 2017: Journal of Cataract and Refractive Surgery
https://www.readbyqxmd.com/read/28693497/inter-rater-reliability-of-amstar-is-dependent-on-the-pair-of-reviewers
#5
Dawid Pieper, Anja Jacobs, Beate Weikert, Alba Fishta, Uta Wegewitz
BACKGROUND: Inter-rater reliability (IRR) is mainly assessed based on only two reviewers of unknown expertise. The aim of this paper is to examine differences in the IRR of the Assessment of Multiple Systematic Reviews (AMSTAR) and R(evised)-AMSTAR depending on the pair of reviewers. METHODS: Five reviewers independently applied AMSTAR and R-AMSTAR to 16 systematic reviews (eight Cochrane reviews and eight non-Cochrane reviews) from the field of occupational health...
July 11, 2017: BMC Medical Research Methodology
https://www.readbyqxmd.com/read/28592510/methodological-utility-of-chemerin-as-a-novel-biomarker-of-immunity-and-metabolism
#6
Fabian Eichelmann, Cornelia Weikert, Romina di Giuseppe, Ronald Biemann, Berend Isermann, Matthias B Schulze, Heiner Boeing, Krasimira Aleksandrova
Chemerin is a recently discovered adipokine with inflammatory and metabolic actions relevant for chronic disease development. However, evidence from human research on the role of chemerin in chronic disease risk is still lacking. We assessed the reliability of plasma chemerin concentrations measured on two occasions over a 4-month period in 207 apparently healthy participants. In addition, we explored the cross-sectional associations between chemerin and inflammatory biomarkers using Spearman partial correlation and multivariable linear regression analyses...
July 2017: Endocrine Connections
https://www.readbyqxmd.com/read/28590285/updates-in-biometry
#7
Rodrigo Guimarães de Souza, Ildamaris Montes de Oca, Isi Esquenazi, Zaina Al-Mohtaseb, Mitchell P Weikert
No abstract text is available yet for this article.
2017: International Ophthalmology Clinics
https://www.readbyqxmd.com/read/28590283/perioperative-imaging-in-corneal-surgery-intraoperative-and-postoperative
#8
Kourtney Houser, Mitchell Weikert, Zaina Al-Mohtaseb
No abstract text is available yet for this article.
2017: International Ophthalmology Clinics
https://www.readbyqxmd.com/read/28590281/new-diagnostics-in-corneal-ectatic-disease
#9
Joshua K Duncan, Isi Esquenazi, Mitchell P Weikert
No abstract text is available yet for this article.
2017: International Ophthalmology Clinics
https://www.readbyqxmd.com/read/28590276/preface-state-of-the-art-and-beyond-anterior-segment-diagnostics
#10
Zaina Nabil Al-Mohtaseb, Mitchell Weikert
No abstract text is available yet for this article.
2017: International Ophthalmology Clinics
https://www.readbyqxmd.com/read/28410720/secondary-intraocular-lens-implantation-complication-rates-visual-acuity-and-refractive-outcomes
#11
Greg Brunin, Ahmar Sajjad, Eric J Kim, Ildamaris Montes de Oca, Mitchell P Weikert, Li Wang, Douglas D Koch, Zaina Al-Mohtaseb
PURPOSE: To compare complication rates, visual acuity, and refractive outcomes of secondary intraocular lens (IOLs) implantation. SETTING: Department of Ophthalmology, Cullen Eye Institute, Baylor College of Medicine, Houston, Texas, USA. DESIGN: Retrospective case series. METHODS: All secondary IOLs placed by the anterior segment service were reviewed. Preoperative data, operative reports, and data from each subsequent postoperative visit were evaluated...
March 2017: Journal of Cataract and Refractive Surgery
https://www.readbyqxmd.com/read/28351470/in-reply
#12
Christian Doehn, Steffen Weikert
No abstract text is available yet for this article.
March 3, 2017: Deutsches Ärzteblatt International
https://www.readbyqxmd.com/read/28317681/comparison-of-biometry-and-intraocular-lens-power-calculation-performed-by-a-new-optical-biometry-device-and-a-reference-biometer
#13
Bruna V Ventura, Marcelo C Ventura, Li Wang, Douglas D Koch, Mitchell P Weikert
PURPOSE: To compare biometry measurements and intraocular lens (IOL) power calculations obtained by a new optical A-scan interferometer biometer (Galilei G6) (new biometer) and a partial coherence interferometer biometer (IOLMaster 500) (reference biometer). SETTING: Private practice, Recife, Brazil. DESIGN: Retrospective comparative study. METHODS: Cataract patients who had biometric measurements with the new biometer and the reference biometer were included in the study...
January 2017: Journal of Cataract and Refractive Surgery
https://www.readbyqxmd.com/read/28137672/multiple-imputation-was-a-valid-approach-to-estimate-absolute-risk-from-a-prediction-model-based-on-case-cohort-data
#14
Kristin Mühlenbruch, Olga Kuxhaus, Romina di Giuseppe, Heiner Boeing, Cornelia Weikert, Matthias B Schulze
OBJECTIVE: To compare weighting methods for Cox regression and multiple imputation (MI) in a case-cohort study in the context of risk prediction modeling. STUDY DESIGN AND SETTING: Based on the European Prospective Investigation into Cancer and Nutrition Potsdam study, we estimated risk scores to predict incident type-2 diabetes using full cohort data and case-cohort data assuming missing information on waist circumference outside the case-cohort (∼90%). Varying weighting approaches and MI were compared with regard to the calculation of relative risks, absolute risks, and predictive abilities including C-index, the net reclassification improvement, and calibration...
April 2017: Journal of Clinical Epidemiology
https://www.readbyqxmd.com/read/28073425/hypertension-in-germany
#15
Hannelore Neuhauser, Claudia Diederichs, Heiner Boeing, Stephan B Felix, Claus Jünger, Roberto Lorbeer, Christine Meisinger, Annette Peters, Henry Völzke, Cornelia Weikert, Philipp Wild, Marcus Dörr
BACKGROUND: Hypertension is a key risk factor. However, population data based on blood pressure measurements in Germany are scarce. METHODS: Standardized blood pressure (BP) measurements and medication data from seven population-based studies conducted in Germany between 1994 and 2012 (66 845 participants, 25-74 years) were analyzed: the EPICPotsdam study (1994-1998, EPIC), the KORA-S4 Study (1999-2001) in Augsburg, and the Gutenberg Health Study (2007-2012, GHS) in Mainz/Mainz-Bingen provided data for descriptive comparisons...
December 2, 2016: Deutsches Ärzteblatt International
https://www.readbyqxmd.com/read/27863829/the-effect-of-carpal-tunnel-release-on-typing-performance
#16
Justin W Zumsteg, Matthew J C Crump, Gordon D Logan, Douglas R Weikert, Donald H Lee
PURPOSE: To describe the effect of carpal tunnel release (CTR) on typing performance. METHODS: We prospectively studied 27 patients undergoing open CTR. Patient demographics and clinical characteristics including nerve conduction studies, electromyography results, and duration of symptoms were collected. Before surgery and at 8 time points after surgery, ranging from 1 to 12 weeks, typing performance for an approximately 500-character paragraph was assessed via an on-line platform...
January 2017: Journal of Hand Surgery
https://www.readbyqxmd.com/read/27808407/extension-of-the-clinical-and-molecular-phenotype-of-diaph1-associated-autosomal-dominant-hearing-loss-dfna1
#17
C Neuhaus, R Lang-Roth, U Zimmermann, R Heller, T Eisenberger, M Weikert, S Markus, M Knipper, H J Bolz
In about 20% of non-syndromic hearing loss (NSHL) cases, inheritance is autosomal dominant (ADNSHL). DIAPH1 mutations define the ADNSHL locus DFNA1. We identified two new families with heterozygous truncating DIAPH1 mutations (p.Ala1210Serfs*31 and p.Arg1213*). In contrast to the extensively studied original DFNA1 family, hearing loss was not confined to low frequencies, but congenital manifestation and rapid progression were confirmed. In line with a recent unrelated study, we identified an association with thrombocytopenia, reclassifying DFNA1 as a syndrome...
June 2017: Clinical Genetics
https://www.readbyqxmd.com/read/27798103/prostate-cancer-risk-regions-at-8q24-and-17q24-are-differentially-associated-with-somatic-tmprss2-erg-fusion-status
#18
Manuel Luedeke, Antje E Rinckleb, Liesel M FitzGerald, Milan S Geybels, Johanna Schleutker, Rosalind A Eeles, Manuel R Teixeira, Lisa Cannon-Albright, Elaine A Ostrander, Steffen Weikert, Kathleen Herkommer, Tiina Wahlfors, Tapio Visakorpi, Katri A Leinonen, Teuvo L J Tammela, Colin S Cooper, Zsofia Kote-Jarai, Sandra Edwards, Chee L Goh, Frank McCarthy, Chris Parker, Penny Flohr, Paula Paulo, Carmen Jerónimo, Rui Henrique, Hans Krause, Sven Wach, Verena Lieb, Tilman T Rau, Walther Vogel, Rainer Kuefer, Matthias D Hofer, Sven Perner, Mark A Rubin, Archana M Agarwal, Doug F Easton, Ali Amin Al Olama, Sara Benlloch, Josef Hoegel, Janet L Stanford, Christiane Maier
Molecular and epidemiological differences have been described between TMPRSS2:ERG fusion-positive and fusion-negative prostate cancer (PrCa). Assuming two molecularly distinct subtypes, we have examined 27 common PrCa risk variants, previously identified in genome-wide association studies, for subtype specific associations in a total of 1221 TMPRSS2:ERG phenotyped PrCa cases. In meta-analyses of a discovery set of 552 cases with TMPRSS2:ERG data and 7650 unaffected men from five centers we have found support for the hypothesis that several common risk variants are associated with one particular subtype rather than with PrCa in general...
December 15, 2016: Human Molecular Genetics
https://www.readbyqxmd.com/read/27796501/higher-serum-asymmetric-dimethylarginine-is-related-to-higher-risk-of-heart-failure-in-the-epic-potsdam-study
#19
Janine Wirth, Dorothee Atzler, Romina di Giuseppe, Kathrin Cordts, Juliane Menzel, Rainer H Böger, Heiner Boeing, Cornelia Weikert, Edzard Schwedhelm
L-Arginine is the substrate of endothelial nitric oxide (NO) synthase forming NO which inherits various biological cardio-protective functions. The dimethylarginines asymmetric (ADMA) and symmetric dimethylarginine (SDMA) can impair the synthesis of NO and are elevated in patients with cardiovascular disease, including heart failure (HF). We investigated the association between dimethylarginines and HF risk in a case-cohort study of the European Prospective Investigation into Cancer and Nutrition (n = 27,548), comprising a random subcohort (n = 2224 including 19 HF cases), and all remaining HF cases (n = 176) that occurred within 8...
January 2017: Amino Acids
https://www.readbyqxmd.com/read/27720136/ima901-a-multipeptide-cancer-vaccine-plus-sunitinib-versus-sunitinib-alone-as-first-line-therapy-for-advanced-or-metastatic-renal-cell-carcinoma-imprint-a-multicentre-open-label-randomised-controlled-phase-3-trial
#20
RANDOMIZED CONTROLLED TRIAL
Brian I Rini, Arnulf Stenzl, Romauld Zdrojowy, Mikhail Kogan, Mikhail Shkolnik, Stephane Oudard, Steffen Weikert, Sergio Bracarda, Simon J Crabb, Jens Bedke, Joerg Ludwig, Dominik Maurer, Regina Mendrzyk, Claudia Wagner, Andrea Mahr, Jens Fritsche, Toni Weinschenk, Steffen Walter, Alexandra Kirner, Harpreet Singh-Jasuja, Carsten Reinhardt, Tim Eisen
BACKGROUND: In a phase 2 study in patients with metastatic renal cell carcinoma, overall survival was associated with T-cell responses against IMA901, a vaccine consisting of ten tumour-associated peptides. In this phase 3 trial, we aimed to determine the clinical effect of adding IMA901 to sunitinib, the standard first-line treatment in metastatic renal cell carcinoma with postulated favourable immunomodulatory effects. METHODS: The IMPRINT study is an open-label, randomised, controlled, phase 3 trial done at 124 clinical sites in 11 countries...
November 2016: Lancet Oncology
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