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Wolfram J Herrmann, Cornelia Weikert, Manuela Bergmann, Heiner Boeing, Verena A Katzke, Rudolf Kaaks, Daniel Tiller, Karin Halina Greiser, Margit Heier, Christa Meisinger, Carsten Oliver Schmidt, Hannelore Neuhauser, Christin Heidemann, Claus Jünger, Philipp S Wild, Sara Helena Schramm, Karl-Heinz Jöckel, Marcus Dörr, Tobias Pischon
BACKGROUND: Cardiovascular and metabolic diseases are a major cause of mortality and loss of quality of life in Germany. Research into risk factors of these diseases requires large population-based cohort studies. Complete and accurate assessment of the incidence of cardiovascular and metabolic diseases is a key element for valid interpretation of the results from such studies. OBJECTIVE: Our aim was to identify population-based cohort studies with incidence of cardiovascular and metabolic diseases in Germany and to summarize their methods for assessment and classification of disease endpoints, including myocardial infarction, type 2 diabetes, stroke, heart failure, and arterial hypertension...
April 2018: Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz
Isabel Fernholz, Juliane Menzel, Hans-Christian Jabusch, Heiner Gembris, Felix Fischer, Friederike Kendel, Gunter Kreutz, Alexander Schmidt, Stefan N Willich, Cornelia Weikert
BACKGROUND: There is only a limited number of studies on associations between musical activity and health issues. It seems that musical activity has physiological and psychological benefits, as well as effects on the mental capacity, but this has been studied only in a few clinical and epidemiological studies. One reason might be that no appropriate survey instrument assessing musical activity is available. AIM OF THE STUDY: Here we provide an overview of survey instruments that assess musicality and musical activity...
February 27, 2018: Das Gesundheitswesen
Cameron Clarke, Shazia F Ali, Michael Murri, Saagar N Patel, Li Wang, Marie Tuft, Mitchell P Weikert, Zaina Al-Mohtaseb
PURPOSE: To identify the preoperative risk factors, intraoperative events, and postoperative complications increasing the risk for poor visual outcomes in resident-performed cataract surgeries at a tertiary-care county hospital. SETTING: Ben Taub General Hospital, Houston, Texas, USA. DESIGN: Retrospective case series. METHODS: Resident-performed cataract surgeries were analyzed for risk factors, comorbidities, and intraoperative and postoperative complications...
December 2017: Journal of Cataract and Refractive Surgery
Eva K Regel, Tobias Weikert, Anna Niehues, Bruno M Moerschbacher, Ratna Singh
Partially acetylated chitosan oligosaccharides (paCOS) have various potential applications in agriculture, biomedicine, and pharmaceutics due to their suitable bioactivities. One method to produce paCOS is partial chemical hydrolysis of chitosan polymers, but that leads to poorly defined mixtures of oligosaccharides. However, the effective production of defined paCOS is crucial for fundamental research and for developing applications. A more promising approach is enzymatic depolymerization of chitosan using chitinases or chitosanases, as the substrate specificity of the enzyme determines the composition of the oligomeric products...
April 2018: Biotechnology and Bioengineering
Juliane Menzel, Ronald Biemann, Krasimira Aleksandrova, Matthias B Schulze, Heiner Boeing, Berend Isermann, Cornelia Weikert
OBJECTIVE: Recent in vitro data suggested that the novel adipokine chemerin may influence bone health. However, only limited evidence of the relationship between chemerin and bone health in humans is available. Therefore, this study aimed to investigate the association between chemerin and broadband ultrasound attenuation (BUA) in peri/premenopausal and postmenopausal women. METHODS: Data from the German population-based European Prospective Investigation into Cancer and Nutrition-Potsdam cohort comprising 404 peri/premenopausal and 279 postmenopausal women were analyzed...
December 4, 2017: Menopause: the Journal of the North American Menopause Society
Anna Floegel, Tilman Kühn, Disorn Sookthai, Theron Johnson, Cornelia Prehn, Ulrike Rolle-Kampczyk, Wolfgang Otto, Cornelia Weikert, Thomas Illig, Martin von Bergen, Jerzy Adamski, Heiner Boeing, Rudolf Kaaks, Tobias Pischon
Metabolomic approaches in prospective cohorts may offer a unique snapshot into early metabolic perturbations that are associated with a higher risk of cardiovascular diseases (CVD) in healthy people. We investigated the association of 105 serum metabolites, including acylcarnitines, amino acids, phospholipids and hexose, with risk of myocardial infarction (MI) and ischemic stroke in the European Prospective Investigation into Cancer and Nutrition (EPIC)-Potsdam (27,548 adults) and Heidelberg (25,540 adults) cohorts...
January 2018: European Journal of Epidemiology
Patricia P Wadowski, Christoph W Kopp, Renate Koppensteiner, Irene M Lang, Joseph Pultar, Silvia Lee, Constantin Weikert, Simon Panzer, Thomas Gremmel
BACKGROUND: Anaemic patients undergoing angioplasty and stenting are at an increased risk of ischaemic events, which may be caused by an inadequate response to antiplatelet therapy with adenosine diphosphate (ADP) P2Y12 inhibitors. In the current study, we investigated the associations between anaemia and on-treatment platelet reactivity in clopidogrel-treated (group 1, n = 306) and prasugrel-/ticagrelor-treated (group 2, n = 109) patients undergoing elective and acute angioplasty with stent implantation, respectively...
January 2018: European Journal of Clinical Investigation
Tobias Weikert, Anna Niehues, Stefan Cord-Landwehr, Margareta J Hellmann, Bruno M Moerschbacher
Chitosanases can be used to produce partially acetylated chitosan oligosaccharides (paCOS) for different applications, provided they are thoroughly characterized. However, recent studies indicate that the established classification system for chitosanases is too simplistic. Here, we apply a highly sensitive method for quantitatively sequencing paCOS to reassess the substrate specificities of the best-characterized class I-III chitosanases. The enzymes' abilities to cleave bonds at GlcNAc residues positioned at subsite (-1) or (+1), on which the classification system is based, vary especially when the substrates have different fractions of acetylation (FA )...
November 22, 2017: Nature Communications
Stefan Sturm, Marie-Laure Delporte, Salah Hadi, Scott Schobel, Lothar Lindemann, Robert Weikert, Georg Jaeschke, Michael Derks, Giuseppe Palermo
AIM: The objectives of this first-in-human study were to evaluate the safety and tolerability, pharmacokinetics and pharmacodynamics, and maximum tolerated dose (MTD) of single ascending oral doses of RG7342, a positive allosteric modulator (PAM) of the metabotropic glutamate receptor 5 (mGlu5) for the treatment of schizophrenia, in healthy male subjects. METHODS: This was a single-centre, randomized, double-blind, adaptive study of 37 subjects receiving single ascending oral doses of RG7342 (ranging from 0...
March 2018: British Journal of Clinical Pharmacology
Juliane Menzel, Romina di Giuseppe, Ronald Biemann, Clemens Wittenbecher, Krasimira Aleksandrova, Fabian Eichelmann, Andreas Fritsche, Matthias B Schulze, Heiner Boeing, Berend Isermann, Cornelia Weikert
The adipokines chemerin and omentin-1 have been suggested to influence cardiovascular function. The study aimed to investigate the longitudinal association between chemerin, omentin-1 concentrations and risk of incident heart failure (HF), respectively. We conducted a case-cohort study nested within the European Prospective Investigation into Cancer and Nutrition (EPIC)-Potsdam cohort (n = 27548) including a randomly drawn subsample and all incident HF cases during a mean follow-up of 8.2 ± 1.5 years...
October 26, 2017: Scientific Reports
Haitze de Vries, Alba Fishta, Beate Weikert, Alejandra Rodriguez Sanchez, Uta Wegewitz
Purpose To present an overview of the existing evidence on prognostic factors of (recurrent) sickness absence (SA) and return to work (RTW) among workers with a common mental disorder (CMD). This scoping review provides information about determinants for SA and RTW, which could be used to develop better interventions aimed at the prevention of SA and promotion of RTW among workers with a CMD. Methods Relevant articles were identified in PubMed, Embase, PsycINFO, PSYNDEX, and SINGLE up to October 2016. In order to be included, studies should provide insight into prognostic factors of SA or RTW of workers with a CMD...
October 4, 2017: Journal of Occupational Rehabilitation
Christopher M Jones, Eric M Padegimas, Nicole Weikert, Samuel Greulich, Asif M Ilyas, Sorin Siegler
BACKGROUND: The purpose of this study was to compare the mechanical properties of metacarpal neck fracture fixation by headless compression screw (HCS) with that of Kirschner wire (KW) cross-pinning and locking plate (LP) fixation. METHODS: A metacarpal neck fracture was created in 30 fourth-generation composite Sawbones metacarpal models. A volar-based wedge was removed using a custom jig to simulate a typical apex dorsal fracture, unstable in flexion. The models were divided into 3 equal groups based on the method of fixation: retrograde cross-pinning with two 1...
September 1, 2017: Hand: Official Journal of the American Association for Hand Surgery
Sophie X Deng, W Barry Lee, Kristin M Hammersmith, Anthony N Kuo, Jennifer Y Li, Joanne F Shen, Mitchell P Weikert, Roni M Shtein
PURPOSE: To review the published literature on the safety and outcomes of Descemet membrane endothelial keratoplasty (DMEK) for the surgical treatment of corneal endothelial dysfunction. METHODS: Literature searches were last conducted in the PubMed and the Cochrane Library databases most recently in May 2017. The searches, which were limited to English-language abstracts, yielded 1085 articles. The panel reviewed the abstracts, and 47 were determined to be relevant to this assessment...
February 2018: Ophthalmology
Mitchell P Weikert
No abstract text is available yet for this article.
August 2017: Journal of Cataract and Refractive Surgery
Eric J Kim, Ahmar Sajjad, Ildamaris Montes de Oca, Douglas D Koch, Li Wang, Mitchell P Weikert, Zaina N Al-Mohtaseb
PURPOSE: To evaluate the refractive outcomes after multifocal intraocular lens (IOL) exchange. SETTING: Cullen Eye Institute, Baylor College of Medicine, Houston, Texas, USA. DESIGN: Retrospective case series. METHODS: Patients had multifocal IOL explantation followed by IOL implantation. Outcome measures included type of IOL, surgical indication, corrected distance visual acuity (CDVA), and refractive prediction error...
June 2017: Journal of Cataract and Refractive Surgery
Dawid Pieper, Anja Jacobs, Beate Weikert, Alba Fishta, Uta Wegewitz
BACKGROUND: Inter-rater reliability (IRR) is mainly assessed based on only two reviewers of unknown expertise. The aim of this paper is to examine differences in the IRR of the Assessment of Multiple Systematic Reviews (AMSTAR) and R(evised)-AMSTAR depending on the pair of reviewers. METHODS: Five reviewers independently applied AMSTAR and R-AMSTAR to 16 systematic reviews (eight Cochrane reviews and eight non-Cochrane reviews) from the field of occupational health...
July 11, 2017: BMC Medical Research Methodology
Fabian Eichelmann, Cornelia Weikert, Romina di Giuseppe, Ronald Biemann, Berend Isermann, Matthias B Schulze, Heiner Boeing, Krasimira Aleksandrova
Chemerin is a recently discovered adipokine with inflammatory and metabolic actions relevant for chronic disease development. However, evidence from human research on the role of chemerin in chronic disease risk is still lacking. We assessed the reliability of plasma chemerin concentrations measured on two occasions over a 4-month period in 207 apparently healthy participants. In addition, we explored the cross-sectional associations between chemerin and inflammatory biomarkers using Spearman partial correlation and multivariable linear regression analyses...
July 2017: Endocrine Connections
Rodrigo Guimarães de Souza, Ildamaris Montes de Oca, Isi Esquenazi, Zaina Al-Mohtaseb, Mitchell P Weikert
No abstract text is available yet for this article.
2017: International Ophthalmology Clinics
Kourtney Houser, Mitchell Weikert, Zaina Al-Mohtaseb
No abstract text is available yet for this article.
2017: International Ophthalmology Clinics
Joshua K Duncan, Isi Esquenazi, Mitchell P Weikert
No abstract text is available yet for this article.
2017: International Ophthalmology Clinics
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