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JOURNAL ARTICLE
T Unger, R de Sousa Ribeiro, M Mokni, T Weikert, J Pohl, A Schwarz, J P O Held, L Sauerzopf, B Kühnis, E Gavagnin, A R Luft, R Gassert, O Lambercy, C Awai Easthope, J G Schönhammer
INTRODUCTION: Clinical assessment of upper limb sensorimotor function post-stroke is often constrained by low sensitivity and limited information on movement quality. To address this gap, recent studies proposed a standardized instrumented drinking task, as a representative daily activity combining different components of functional arm use. Although kinematic movement quality measures for this task are well-established, and optical motion capture (OMC) has proven effective in their measurement, its clinical application remains limited...
2024: Frontiers in digital health
#2
REVIEW
C Doehn, L Bergmann, J Decker, T Gauler, V Grünwald, St Weikert, S Krege
BACKGROUND: Renal cell carcinoma is the third most common tumor among urological tumors. In Germany more than 14,000 people are affected every year. The sex ratio is 2/3 men and 1/3 women. OBJECTIVES: The S3 guideline is intended to provide all disciplines dealing with renal cell carcinoma with the current status of diagnostics, therapy and follow-up care of the patients with this tumor. MATERIALS AND METHODS: The first version of the German guideline on renal cell carcinoma was published in 2015...
April 11, 2024: Urologie
#3
JOURNAL ARTICLE
Sriya Nemani, Sara Chaker, Helen Ismail, Julia Yao, Monal Chang, Hakmook Kang, Mihir Desai, Douglas Weikert, Panambur L Bhandari, Brian Drolet, Brinkley Sandvall, John B Hill, Wesley Thayer
BACKGROUND: Peripheral nerve repair is limited by Wallerian degeneration coupled with the slow and inconsistent rates of nerve regrowth. In more proximal injuries, delayed nerve regeneration can cause debilitating muscle atrophy. Topical application of polyethylene glycol (PEG) during neurorrhaphy facilitates the fusion of severed axonal membranes, immediately restoring action potentials across the coaptation site. In preclinical animal models, PEG-fusion resulted in remarkable early functional recovery...
February 7, 2024: Plastic and Reconstructive Surgery
#4
JOURNAL ARTICLE
Beate Weikert, Tobias Siegfried Kramer, Frank Schwab, Chris Graf-Allgeier, Solvy Ingrid Wolke, Petra Gastmeier, Christine Geffers
OBJECTIVES: Patients with haemodialysis catheters are susceptible to dialysis-associated infections, particularly bloodstream infections. There have been few systematic attempts to reduce this burden. Our study aimed to investigate the effect of a multimodal prevention strategy on dialysis-associated infection events (DAIE) among haemodialysis outpatients. METHODS: A multicentre, stepped wedge, cluster-randomized controlled trial was done from October 2019 to September 2021...
February 3, 2024: Clinical Microbiology and Infection
#5
JOURNAL ARTICLE
Beate Schlosser, Beate Weikert, Giovanni-Battista Fucini, Britta Kohlmorgen, Axel Kola, Anna Weber, Norbert Thoma, Michael Behnke, Frank Schwab, Petra Gastmeier, Christine Geffers, Seven Johannes Sam Aghdassi
BACKGROUND: An increase in patients with multidrug-resistant organisms and associated outbreaks during the COVID-19 pandemic have been reported in various settings, including low-endemic settings. Here, we report three distinct carbapenem-resistant Acinetobacter baumannii (CRAB) outbreaks in five intensive care units of a university hospital in Berlin, Germany during the COVID-19 pandemic. METHODS: A case-control study was conducted with the objective of identifying risk factors for CRAB acquisition in outbreak situations...
January 23, 2024: BMC Infectious Diseases
#6
JOURNAL ARTICLE
Karim Kozhaya, Peter I Kenny, Li Wang, Mitchell P Weikert, Douglas D Koch
No abstract text is available yet for this article.
January 18, 2024: Journal of Cataract and Refractive Surgery
#7
JOURNAL ARTICLE
Achuth Nair, Fernando Zvietcovich, Manmohan Singh, Mitchell P Weikert, Salavat R Aglyamov, Kirill V Larin
SIGNIFICANCE: The biomechanical impact of refractive surgery has long been an area of investigation. Changes to the cornea structure cause alterations to its mechanical integrity, but few studies have examined its specific mechanical impact. AIM: To quantify how the biomechanical properties of the cornea are altered by laser assisted in situ keratomileusis (LASIK) using optical coherence elastography (OCE) in ex vivo porcine corneas. APPROACH: Three OCE techniques, wave-based air-coupled ultrasound (ACUS) OCE, heartbeat (Hb) OCE, and compression OCE were used to measure the mechanical properties of paired porcine corneas, where one eye of the pair was left untreated, and the fellow eye underwent LASIK...
January 2024: Journal of Biomedical Optics
#8
LETTER
Karim Kozhaya, Li Wang, Mitchell P Weikert, Douglas D Koch
No abstract text is available yet for this article.
November 1, 2023: Journal of Cataract and Refractive Surgery
#9
JOURNAL ARTICLE
B Weikert, T S Kramer, F Schwab, C Graf-Allgeier, J-O Clausmeyer, S I Wolke, P Gastmeier, C Geffers
INTRODUCTION: Patients receiving maintenance haemodialysis are at risk of catheter-related infections. Up to now, there has been no standardized surveillance tool in Germany to evaluate infection events in haemodialysis outpatients. As such, this study aimed to implement an online-based surveillance tool in outpatient dialysis facilities, and to report the first national surveillance data for haemodialysis patients in Germany from October 2019 until September 2021. METHODS: Outpatient dialysis facilities reported three types of dialysis-associated infection event (DAIE): bloodstream infections, intravenous antimicrobial starts, and local access site infections...
December 2023: Journal of Hospital Infection
#10
JOURNAL ARTICLE
Peter I Kenny, Karim Kozhaya, Paulina Truong, Li Wang, Douglas D Koch, Mitchell P Weikert
PURPOSE: to compare the predictive accuracy of the biometer-embedded Barrett True-K TK and novel total corneal power methods of intraocular lens (IOL) power calculation in eyes with prior laser vision correction (LVC) for myopia. SETTING: Academic clinical practice. DESIGN: Retrospective case series. METHODS: IOL power formulas were assessed using measurements from a swept-source optical coherence biometer. Refractive prediction errors (RPEs) were calculated for the Barrett True-K TK, EVO 2...
September 5, 2023: Journal of Cataract and Refractive Surgery
#11
JOURNAL ARTICLE
Karim Kozhaya, Peter I Kenny, Saina Esfandiari, Li Wang, Mitchell P Weikert, Douglas D Koch
PURPOSE: Assess the performances of four intraocular lenses (IOLs) in various spherical aberration (SA) conditions, using the VAO adaptive optics simulator (Voptica S.L.). SETTING: Cullen Eye Institute, Baylor College of Medicine, Houston, TX. DESIGN: Prospective case series. METHODS: Distance-corrected visual acuities at distance (CDVA), intermediate (DCIVA), and near (DCNVA) were measured in 42 dilated pseudophakic eyes at baseline and with ocular SA ranging from -0...
September 13, 2023: Journal of Cataract and Refractive Surgery
#12
JOURNAL ARTICLE
Jürgen M Steinacker, Willem van Mechelen, Wilhelm Bloch, Mats Börjesson, Maurizio Casasco, Bernd Wolfarth, Carolin Knoke, Theodora Papadopoulou, Janine Wendt, Hashel Al Tunaiji, Dietrich Andresen, Olena Andrieieva, Norbert Bachl, Victoriya Badtieva, Friedhelm J Beucher, Cheri A Blauwet, Jose-Antonio Casajus Mallen, Ju-Ho Chang, German Clénin, Naama Constantini, Demitri Constantinou, Luigi Di Luigi, Lukas Declercq, Stephane Doutreleau, Svitlana Drozdovska, Martine Duclos, Andrea Ermolao, Thomas Fischbach, Anastasia N Fischer, Chiara Fossati, Jeorge Franchella, Mark Fulcher, Jan C Galle, Christian Gerloff, Evelina Georgiades, Boris Gojanovic, Marcela González Gross, Andy Grote, Martin Halle, Hans Hauner, Matthew Payton Herring, Mikio Hiura, Kerstin Holze, Gerhard Huber, David Hughes, Mark R Hutchinson, Anca Ionescu, Dina Christina Janse van Rensburg, Anna Jegier, Natasha Jones, Kirsten Kappert-Gonther, Monika Kellerer, Yutaka Kimura, Agrita Kiopa, Bernd Kladny, Gerhard Koch, Elin Kolle, Greg Kolt, Yiannis Koutedakis, Stephan Kress, Susi Kriemler, Jens Kröger, Christian Kuhn, Roman Laszlo, Ralph Lehnert, François J Lhuissier, Kerstin Lüdtke, Shigeru Makita, Pedro Manonelles Marqueta, Winfried März, Kirill Micallef-Stafrace, Mike Miller, Melita Moore, Erich Müller, Daniel Neunhäuserer, I Renay Onur, Vahur Ööpik, Malgorzata Perl, Anastassios Philippou, Hans-Georg Predel, Sebastien Racinais, Algirdas Raslanas, Ruediger Reer, Klaus Reinhardt, Claus Reinsberger, Sandra Rozenstoka, Robert Sallis, Luis B Sardinha, Martin Scherer, Jasper Schipperijn, Romain Seil, Benedict Tan, Arno Schmidt-Trucksäss, Nils Schumacher, Bernhard Schwaab, Ansgar Schwirtz, Masato Suzuki, Jeroen Swart, Ralph Tiesler, Ulf Tippelt, Eleanor Tillet, Jane Thornton, Bulent Ulkar, Eve Unt, Evert Verhagen, Thomas Weikert, Roberto Vettor, Sheng Zeng, Richard Budgett, Lars Engebretsen, Ugur Erdener, Fabio Pigozzi, Yannis P Pitsiladis
Non-communicable diseases (NCDs), including coronary heart disease, stroke, hypertension, type 2 diabetes, dementia, depression and cancers, are on the rise worldwide and are often associated with a lack of physical activity (PA). Globally, the levels of PA among individuals are below WHO recommendations. A lack of PA can increase morbidity and mortality, worsen the quality of life and increase the economic burden on individuals and society. In response to this trend, numerous organisations came together under one umbrella in Hamburg, Germany, in April 2021 and signed the 'Hamburg Declaration'...
2023: BMJ Open Sport & Exercise Medicine
#13
JOURNAL ARTICLE
Yan Li, Christina Vogel, Liubov S Kalinichenko, Harald Hübner, Dorothee Weikert, Natascha Schaefer, Peter Gmeiner, Carmen Villmann, Monika Pischetsrieder, Christian P Müller
Alcohol consumption is a widespread behaviour that may eventually result in the development of alcohol use disorder (AUD). Alcohol, however, is rarely consumed in pure form but in fruit- or corn-derived preparations, like beer. These preparations add other compounds to the consumption, which may critically modify alcohol intake and AUD risk. We investigated the effects of hordenine, a barley-derived beer compound on alcohol use-related behaviours. We found that the dopamine D2 receptor agonist hordenine (50 mg/kg) limited ongoing alcohol consumption and prophylactically diminished relapse drinking after withdrawal in mice...
August 2023: Addiction Biology
#14
JOURNAL ARTICLE
Alan Hegron, Chloe J Peach, Raquel Tonello, Philipp Seemann, Shavonne Teng, Rocco Latorre, Harald Huebner, Dorothee Weikert, Jeanette Rientjes, Nicholas A Veldhuis, Daniel P Poole, Dane D Jensen, Alex R B Thomsen, Brian L Schmidt, Wendy L Imlach, Peter Gmeiner, Nigel W Bunnett
The hypothesis that sustained G protein-coupled receptor (GPCR) signaling from endosomes mediates pain is based on studies with endocytosis inhibitors and lipid-conjugated or nanoparticle-encapsulated antagonists targeted to endosomes. GPCR antagonists that reverse sustained endosomal signaling and nociception are needed. However, the criteria for rational design of such compounds are ill-defined. Moreover, the role of natural GPCR variants, which exhibit aberrant signaling and endosomal trafficking, in maintaining pain is unknown...
May 30, 2023: Proceedings of the National Academy of Sciences of the United States of America
#15
JOURNAL ARTICLE
Thomas Weikert, Harold I Litt, William H Moore, Mohammed Abed, Lea Azour, Abass M Noor, Liene Friebe, Nathaniel Linna, Halid Ziya Yerebakan, Yoshihisa Shinagawa, Gerardo Hermosillo, Simon Allen-Raffl, Mahesh Ranganath, Alexander W Sauter
RATIONALE AND OBJECTIVES: Finding comparison to relevant prior studies is a requisite component of the radiology workflow. The purpose of this study was to evaluate the impact of a deep learning tool simplifying this time-consuming task by automatically identifying and displaying the finding in relevant prior studies. MATERIALS AND METHODS: The algorithm pipeline used in this retrospective study, TimeLens (TL), is based on natural language processing and descriptor-based image-matching algorithms...
May 18, 2023: Academic Radiology
#16
JOURNAL ARTICLE
Karim Kozhaya, Allison J Chen, Manasi Joshi, Peter I Kenny, Douglas D Koch, Nicole Fram, Mitchell P Weikert, Li Wang, Sumitra S Khandelwal
PURPOSE: To assess the performance of multiple intraocular lens (IOL) formulas in eyes with keratoconus. METHODS: Eyes with stable keratoconus scheduled for cataract surgery with biometry measurements on the Lenstar LS900 (Haag-Streit) were included. Prediction errors were calculated using 11 different formulas, including two with keratoconus modifiers. Primary outcomes compared standard deviations, mean and median numerical errors, and percentage of eyes within diopter (D) ranges across all eyes with subgroup analysis according to anterior keratometric values...
April 2023: Journal of Refractive Surgery
#17
JOURNAL ARTICLE
Fabrizio Fierro, Lior Peri, Harald Hübner, Alina Tabor-Schkade, Lukas Waterloo, Stefan Löber, Tara Pfeiffer, Dorothee Weikert, Tamir Dingjan, Eitan Margulis, Peter Gmeiner, Masha Y Niv
The human GPCR family comprises circa 800 members, activated by hundreds of thousands of compounds. Bitter taste receptors, TAS2Rs, constitute a large and distinct subfamily, expressed orally and extra-orally and involved in physiological and pathological conditions. TAS2R14 is the most promiscuous member, with over 150 agonists and 3 antagonists known prior to this study. Due to the scarcity of inhibitors and to the importance of chemical probes for exploring TAS2R14 functions, we aimed to discover new ligands for this receptor, with emphasis on antagonists...
April 3, 2023: Cellular and Molecular Life Sciences: CMLS
#18
JOURNAL ARTICLE
Peter I Kenny, Karim Kozhaya, Paulina Truong, Mitchell P Weikert, Li Wang, Warren E Hill, Douglas D Koch
PURPOSE: In short eyes, to compare the predictive accuracy of newer intraocular lens (IOL) power calculation formulas using traditional and segmented axial length (AL) measurements. SETTING: Cullen Eye Institute, Baylor College of Medicine, Houston, TX and East Valley Ophthalmology, Mesa, AZ. DESIGN: Multi-center retrospective case series. METHODS: Measurements from an optical biometer were collected in eyes with AL < 22mm...
March 17, 2023: Journal of Cataract and Refractive Surgery
#19
JOURNAL ARTICLE
Raphael Sexauer, Patryk Hejduk, Karol Borkowski, Carlotta Ruppert, Thomas Weikert, Sophie Dellas, Noemi Schmidt
OBJECTIVES: High breast density is a well-known risk factor for breast cancer. This study aimed to develop and adapt two (MLO, CC) deep convolutional neural networks (DCNN) for automatic breast density classification on synthetic 2D tomosynthesis reconstructions. METHODS: In total, 4605 synthetic 2D images (1665 patients, age: 57 ± 37 years) were labeled according to the ACR (American College of Radiology) density (A-D). Two DCNNs with 11 convolutional layers and 3 fully connected layers each, were trained with 70% of the data, whereas 20% was used for validation...
March 1, 2023: European Radiology
#20
JOURNAL ARTICLE
Lukas Waterloo, Harald Hübner, Fabrizio Fierro, Tara Pfeiffer, Regine Brox, Stefan Löber, Dorothee Weikert, Masha Y Niv, Peter Gmeiner
The bitter taste receptor TAS2R14 is a G protein-coupled receptor that is found on the tongue as well as in the human airway smooth muscle and other extraoral tissues. Because its activation causes bronchodilatation, TAS2R14 is a potential target for the treatment of asthma or chronic obstructive pulmonary disease. Structural variations of flufenamic acid, a nonsteroidal anti-inflammatory drug, led us to 2-aminopyridines showing considerable efficacy and potency in an IP1 accumulation assay. In combination with an exchange of the carboxylic moiety by a tetrazole unit, a set of promising new TAS2R14 agonists was developed...
February 27, 2023: Journal of Medicinal Chemistry
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