keyword
https://read.qxmd.com/read/36940190/efficacy-of-segmented-axial-length-and-ai-approaches-to-iol-power-calculation-in-short-eyes
#21
JOURNAL ARTICLE
Peter I Kenny, Karim Kozhaya, Paulina Truong, Mitchell P Weikert, Li Wang, Warren E Hill, Douglas D Koch
PURPOSE: In short eyes, to compare the predictive accuracy of newer intraocular lens (IOL) power calculation formulas using traditional and segmented axial length (AL) measurements. SETTING: Cullen Eye Institute, Baylor College of Medicine, Houston, TX and East Valley Ophthalmology, Mesa, AZ. DESIGN: Multi-center retrospective case series. METHODS: Measurements from an optical biometer were collected in eyes with AL < 22mm...
March 17, 2023: Journal of Cataract and Refractive Surgery
https://read.qxmd.com/read/36863589/analyzing-golf-course-pesticide-risk-across-the-us-and-europe-the-importance-of-regulatory-environment
#22
JOURNAL ARTICLE
Michael A H Bekken, Douglas J Soldat, Paul L Koch, Carl S Schimenti, Frank S Rossi, Trygve S Aamlid, Karin J Hesselsøe, Torben K Petersen, Chase M Straw, J Bryan Unruh, Alec R Kowalewski, Christian Spring
This study quantifies golf course pesticide risk in five regions across the US (Florida, East Texas, Northwest, Midwest, and Northeast) and three countries in Europe (UK, Denmark, and Norway) with the objective of determining how pesticide risk on golf courses varied as a function of climate, regulatory environment, and facility-level economic factors. The hazard quotient model was used to estimate acute pesticide risk to mammals specifically. Data from 68 golf courses are included in the study, with a minimum of at least five golf courses in each region...
May 20, 2023: Science of the Total Environment
https://read.qxmd.com/read/36791210/age-dependent-impairment-in-antibody-responses-elicited-by-a-homologous-coronavac-booster-dose
#23
JOURNAL ARTICLE
Bruno Andraus Filardi, Valter Silva Monteiro, Pedro Vellosa Schwartzmann, Vivian do Prado Martins, Luis Eduardo Rosa Zucca, Gabriela Crispim Baiocchi, Amyn A Malik, Julio Silva, Anne M Hahn, Nicholas F G Chen, Kien Pham, Eddy Pérez-Then, Marija Miric, Vivian Brache, Leila Cochon, Rafael A Larocca, Roberto Della Rosa Mendez, Douglas Bardini Silveira, Aguinaldo Roberto Pinto, Julio Croda, Inci Yildirim, Saad B Omer, Albert I Ko, Sten H Vermund, Nathan D Grubaugh, Akiko Iwasaki, Carolina Lucas, Chantal B F Vogels, Mallery Breban, Tobias R Koch, Chrispin Chaguza, Irina Tikhonova, Christopher Castaldi, Shrikant Mane, Bony De Kumar, David Ferguson, Nicholas Kerantzas, David Peaper, Marie L Landry, Wade Schulz
The emergence of the SARS-CoV-2 Omicron sublineages resulted in increased transmission rates and reduced protection from vaccines. To counteract these effects, multiple booster strategies were used in different countries, although data comparing their efficiency in improving protective immunity remain sparse, especially among vulnerable populations, including older adults. The inactivated CoronaVac vaccine was among the most widely distributed vaccine worldwide and was essential in the early control of SARS-CoV-2-related hospitalizations and deaths...
February 15, 2023: Science Translational Medicine
https://read.qxmd.com/read/36753322/surgeons-need-to-know-more-about-iol-design-for-accurate-power-calculation
#24
JOURNAL ARTICLE
Thomas Olsen, David L Cooke, Oliver Findl, Damien Gatinel, Douglas Koch, Achim Langenbucher, Ronald B Melles, Tun K Yeo
Improvement in biometry and formulas have raised the bar for accurate IOL power calculation. However, when we look closely at the performance of a specific IOL model, we often find that the prediction error varies with the implant power. This phenomenon has no explanation other than the optic design of the IOL has shifted over the power range, thereby disrupting the assumptions of the calculations. By this report we call the industry to be more transparent and disclose the basic information about the IOL design that is important for accurate IOL power calculation...
February 6, 2023: Journal of Cataract and Refractive Surgery
https://read.qxmd.com/read/36737667/author-correction-screening-for-cd19-specific-chimaeric-antigen-receptors-with-enhanced-signalling-via-a-barcoded-library-of-intracellular-domains
#25
Khloe S Gordon, Taeyoon Kyung, Caleb R Perez, Patrick V Holec, Azucena Ramos, Angela Q Zhang, Yash Agarwal, Yunpeng Liu, Catherine E Koch, Alina Starchenko, Brian A Joughin, Douglas A Lauffenburger, Darrell J Irvine, Michael T Hemann, Michael E Birnbaum
No abstract text is available yet for this article.
February 3, 2023: Nature Biomedical Engineering
https://read.qxmd.com/read/36689649/recent-and-future-declines-of-a-historically-widespread-pollinator-linked-to-climate-land-cover-and-pesticides
#26
JOURNAL ARTICLE
William M Janousek, Margaret R Douglas, Syd Cannings, Marion A Clément, Casey M Delphia, Jeffrey G Everett, Richard G Hatfield, Douglas A Keinath, Jonathan B Uhuad Koch, Lindsie M McCabe, John M Mola, Jane E Ogilvie, Imtiaz Rangwala, Leif L Richardson, Ashley T Rohde, James P Strange, Lusha M Tronstad, Tabitha A Graves
The acute decline in global biodiversity includes not only the loss of rare species, but also the rapid collapse of common species across many different taxa. The loss of pollinating insects is of particular concern because of the ecological and economic values these species provide. The western bumble bee ( Bombus occidentalis ) was once common in western North America, but this species has become increasingly rare through much of its range. To understand potential mechanisms driving these declines, we used Bayesian occupancy models to investigate the effects of climate and land cover from 1998 to 2020, pesticide use from 2008 to 2014, and projected expected occupancy under three future scenarios...
January 31, 2023: Proceedings of the National Academy of Sciences of the United States of America
https://read.qxmd.com/read/36630436/astigmatism-profile-in-a-large-series-of-brazilian-patients
#27
JOURNAL ARTICLE
Bruna V Ventura, Ingrid A Pacheco, Camilla A Menezes, Camilla S Rocha, Taciana M M Higino, Camila V Ventura, Douglas Koch, Walton Nosé
PURPOSE: To assess anterior, posterior, and total corneal astigmatism in a large sample of Brazilian patients. METHODS: In this retrospective cross-sectional study, all patients whose corneas were imaged with the Galilei G6 (Ziemer Ophthalmology) between January 2017 and February 2019 at HOPE Eye Hospital, in Recife, Brazil, were eligible to participate. Anterior, posterior, and total corneal astigmatism values were collected and analyzed. RESULTS: The study included 3,253 eyes of 1,919 patients...
January 2023: Journal of Refractive Surgery
https://read.qxmd.com/read/36602803/massed-vs-intensive-outpatient-prolonged-exposure-for-combat-related-posttraumatic-stress-disorder-a-randomized-clinical-trial
#28
RANDOMIZED CONTROLLED TRIAL
Alan L Peterson, Tabatha H Blount, Edna B Foa, Lily A Brown, Carmen P McLean, Jim Mintz, Richard P Schobitz, Bryann R DeBeer, Joseph Mignogna, Brooke A Fina, Wyatt R Evans, Samantha Synett, Brittany N Hall-Clark, Timothy O Rentz, Christian Schrader, Jeffrey S Yarvis, Katherine A Dondanville, Hunter Hansen, Vanessa M Jacoby, Jose Lara-Ruiz, Casey L Straud, Willie J Hale, Dhiya Shah, Lauren M Koch, Kelsi M Gerwell, Stacey Young-McCaughan, Brett T Litz, Eric C Meyer, Abby E Blankenship, Douglas E Williamson, John D Roache, Martin A Javors, Allah-Fard M Sharrieff, Barbara L Niles, Terence M Keane
IMPORTANCE: Improved, efficient, and acceptable treatments are needed for combat-related posttraumatic stress disorder (PTSD). OBJECTIVE: To determine the efficacy of 2 compressed prolonged exposure (PE) therapy outpatient treatments for combat-related PTSD. DESIGN, SETTING, AND PARTICIPANTS: This randomized clinical trial was conducted among military personnel and veterans at 4 sites in Texas from 2017 to 2019. Assessors were blinded to conditions...
January 3, 2023: JAMA Network Open
https://read.qxmd.com/read/36515925/identification-of-novel-replicable-genetic-risk-loci-for-suicidal-thoughts-and-behaviors-among-us-military-veterans
#29
JOURNAL ARTICLE
Nathan A Kimbrel, Allison E Ashley-Koch, Xue J Qin, Jennifer H Lindquist, Melanie E Garrett, Michelle F Dennis, Lauren P Hair, Jennifer E Huffman, Daniel A Jacobson, Ravi K Madduri, Jodie A Trafton, Hilary Coon, Anna R Docherty, Niamh Mullins, Douglas M Ruderfer, Philip D Harvey, Benjamin H McMahon, David W Oslin, Jean C Beckham, Elizabeth R Hauser, Michael A Hauser
IMPORTANCE: Suicide is a leading cause of death; however, the molecular genetic basis of suicidal thoughts and behaviors (SITB) remains unknown. OBJECTIVE: To identify novel, replicable genomic risk loci for SITB. DESIGN, SETTING, AND PARTICIPANTS: This genome-wide association study included 633 778 US military veterans with and without SITB, as identified through electronic health records. GWAS was performed separately by ancestry, controlling for sex, age, and genetic substructure...
February 1, 2023: JAMA Psychiatry
https://read.qxmd.com/read/36368317/influence-of-claustrum-on-cortex-varies-by-area-layer-and-cell-type
#30
JOURNAL ARTICLE
Ethan G McBride, Saurabh R Gandhi, Jacqulyn R Kuyat, Douglas R Ollerenshaw, Anton Arkhipov, Christof Koch, Shawn R Olsen
The claustrum is a small subcortical structure with widespread connections to disparate regions of the cortex. However, the impact of the claustrum on cortical activity is not fully understood, particularly beyond frontal areas. Here, using optogenetics and multi-regional Neuropixels recordings from over 15,000 cortical neurons in awake mice, we demonstrate that the effect of claustrum input to the cortex differs depending on brain area, layer, and cell type. Brief claustrum stimulation, producing approximately 1 spike per claustrum neuron, affects many fast spiking (FS; putative inhibitory) but relatively fewer regular-spiking (RS; putative excitatory) cortical neurons and leads to a modest decrease in population activity in frontal cortical areas...
January 18, 2023: Neuron
https://read.qxmd.com/read/36018710/lawson-criterion-for-ignition-exceeded-in-an-inertial-fusion-experiment
#31
JOURNAL ARTICLE
H Abu-Shawareb, R Acree, P Adams, J Adams, B Addis, R Aden, P Adrian, B B Afeyan, M Aggleton, L Aghaian, A Aguirre, D Aikens, J Akre, F Albert, M Albrecht, B J Albright, J Albritton, J Alcala, C Alday, D A Alessi, N Alexander, J Alfonso, N Alfonso, E Alger, S J Ali, Z A Ali, W E Alley, P Amala, P A Amendt, P Amick, S Ammula, C Amorin, D J Ampleford, R W Anderson, T Anklam, N Antipa, B Appelbe, C Aracne-Ruddle, E Araya, M Arend, P Arnold, T Arnold, J Asay, L J Atherton, D Atkinson, R Atkinson, J M Auerbach, B Austin, L Auyang, A S Awwal, J Ayers, S Ayers, T Ayers, S Azevedo, B Bachmann, C A Back, J Bae, D S Bailey, J Bailey, T Baisden, K L Baker, H Baldis, D Barber, M Barberis, D Barker, A Barnes, C W Barnes, M A Barrios, C Barty, I Bass, S H Batha, S H Baxamusa, G Bazan, J K Beagle, R Beale, B R Beck, J B Beck, M Bedzyk, R G Beeler, R G Beeler, W Behrendt, L Belk, P Bell, M Belyaev, J F Benage, G Bennett, L R Benedetti, L X Benedict, R Berger, T Bernat, L A Bernstein, B Berry, L Bertolini, G Besenbruch, J Betcher, R Bettenhausen, R Betti, B Bezzerides, S D Bhandarkar, R Bickel, J Biener, T Biesiada, K Bigelow, J Bigelow-Granillo, V Bigman, R M Bionta, N W Birge, M Bitter, A C Black, R Bleile, D L Bleuel, E Bliss, E Bliss, B Blue, T Boehly, K Boehm, C D Boley, R Bonanno, E J Bond, T Bond, M J Bonino, M Borden, J-L Bourgade, J Bousquet, J Bowers, M Bowers, R Boyd, A Bozek, D K Bradley, K S Bradley, P A Bradley, L Bradley, L Brannon, P S Brantley, D Braun, T Braun, K Brienza-Larsen, T M Briggs, J Britten, E D Brooks, D Browning, M W Bruhn, T A Brunner, H Bruns, G Brunton, B Bryant, T Buczek, J Bude, L Buitano, S Burkhart, J Burmark, A Burnham, R Burr, L E Busby, B Butlin, R Cabeltis, M Cable, W H Cabot, B Cagadas, J Caggiano, R Cahayag, S E Caldwell, S Calkins, D A Callahan, J Calleja-Aguirre, L Camara, D Camp, E M Campbell, J H Campbell, B Carey, R Carey, K Carlisle, L Carlson, L Carman, J Carmichael, A Carpenter, C Carr, J A Carrera, D Casavant, A Casey, D T Casey, A Castillo, E Castillo, J I Castor, C Castro, W Caughey, R Cavitt, J Celeste, P M Celliers, C Cerjan, G Chandler, B Chang, C Chang, J Chang, L Chang, R Chapman, T Chapman, L Chase, H Chen, H Chen, K Chen, L-Y Chen, B Cheng, J Chittenden, C Choate, J Chou, R E Chrien, M Chrisp, K Christensen, M Christensen, A R Christopherson, M Chung, J A Church, A Clark, D S Clark, K Clark, R Clark, L Claus, B Cline, J A Cline, J A Cobble, K Cochrane, B Cohen, S Cohen, M R Collette, G Collins, L A Collins, T J B Collins, A Conder, B Conrad, M Conyers, A W Cook, D Cook, R Cook, J C Cooley, G Cooper, T Cope, S R Copeland, F Coppari, J Cortez, J Cox, D H Crandall, J Crane, R S Craxton, M Cray, A Crilly, J W Crippen, D Cross, M Cuneo, G Cuotts, C E Czajka, D Czechowicz, T Daly, P Danforth, R Darbee, B Darlington, P Datte, L Dauffy, G Davalos, S Davidovits, P Davis, J Davis, S Dawson, R D Day, T H Day, M Dayton, C Deck, C Decker, C Deeney, K A DeFriend, G Deis, N D Delamater, J A Delettrez, R Demaret, S Demos, S M Dempsey, R Desjardin, T Desjardins, M P Desjarlais, E L Dewald, J DeYoreo, S Diaz, G Dimonte, T R Dittrich, L Divol, S N Dixit, J Dixon, E S Dodd, D Dolan, A Donovan, M Donovan, T Döppner, C Dorrer, N Dorsano, M R Douglas, D Dow, J Downie, E Downing, M Dozieres, V Draggoo, D Drake, R P Drake, T Drake, G Dreifuerst, D F DuBois, P F DuBois, G Dunham, R Dylla-Spears, A K L Dymoke-Bradshaw, B Dzenitis, C Ebbers, M Eckart, S Eddinger, D Eder, D Edgell, M J Edwards, P Efthimion, J H Eggert, B Ehrlich, P Ehrmann, S Elhadj, C Ellerbee, N S Elliott, C L Ellison, F Elsner, M Emerich, K Engelhorn, T England, E English, P Epperson, R Epstein, G Erbert, M A Erickson, D J Erskine, A Erlandson, R J Espinosa, C Estes, K G Estabrook, S Evans, A Fabyan, J Fair, R Fallejo, N Farmer, W A Farmer, M Farrell, V E Fatherley, M Fedorov, E Feigenbaum, M Feit, W Ferguson, J C Fernandez, A Fernandez-Panella, S Fess, J E Field, C V Filip, J R Fincke, T Finn, S M Finnegan, R G Finucane, M Fischer, A Fisher, J Fisher, B Fishler, D Fittinghoff, P Fitzsimmons, M Flegel, K A Flippo, J Florio, J Folta, P Folta, L R Foreman, C Forrest, A Forsman, J Fooks, M Foord, R Fortner, K Fournier, D E Fratanduono, N Frazier, T Frazier, C Frederick, M S Freeman, J Frenje, D Frey, G Frieders, S Friedrich, D H Froula, J Fry, T Fuller, J Gaffney, S Gales, B Le Galloudec, K K Le Galloudec, A Gambhir, L Gao, W J Garbett, A Garcia, C Gates, E Gaut, P Gauthier, Z Gavin, J Gaylord, M Geissel, F Génin, J Georgeson, H Geppert-Kleinrath, V Geppert-Kleinrath, N Gharibyan, J Gibson, C Gibson, E Giraldez, V Glebov, S G Glendinning, S Glenn, S H Glenzer, S Goade, P L Gobby, S R Goldman, B Golick, M Gomez, V Goncharov, D Goodin, P Grabowski, E Grafil, P Graham, J Grandy, E Grasz, F Graziani, G Greenman, J A Greenough, A Greenwood, G Gregori, T Green, J R Griego, G P Grim, J Grondalski, S Gross, J Guckian, N Guler, B Gunney, G Guss, S Haan, J Hackbarth, L Hackel, R Hackel, C Haefner, C Hagmann, K D Hahn, S Hahn, B J Haid, B M Haines, B M Hall, C Hall, G N Hall, M Hamamoto, S Hamel, C E Hamilton, B A Hammel, J H Hammer, G Hampton, A Hamza, A Handler, S Hansen, D Hanson, R Haque, D Harding, E Harding, J D Hares, D B Harris, J A Harte, E P Hartouni, R Hatarik, S Hatchett, A A Hauer, M Havre, R Hawley, J Hayes, J Hayes, S Hayes, A Hayes-Sterbenz, C A Haynam, D A Haynes, D Headley, A Heal, J E Heebner, S Heerey, G M Heestand, R Heeter, N Hein, C Heinbockel, C Hendricks, M Henesian, J Heninger, J Henrikson, E A Henry, E B Herbold, M R Hermann, G Hermes, J E Hernandez, V J Hernandez, M C Herrmann, H W Herrmann, O D Herrera, D Hewett, R Hibbard, D G Hicks, D Hill, K Hill, T Hilsabeck, D E Hinkel, D D Ho, V K Ho, J K Hoffer, N M Hoffman, M Hohenberger, M Hohensee, W Hoke, D Holdener, F Holdener, J P Holder, B Holko, D Holunga, J F Holzrichter, J Honig, D Hoover, D Hopkins, L Berzak Hopkins, M Hoppe, M L Hoppe, J Horner, R Hornung, C J Horsfield, J Horvath, D Hotaling, R House, L Howell, W W Hsing, S X Hu, H Huang, J Huckins, H Hui, K D Humbird, J Hund, J Hunt, O A Hurricane, M Hutton, K H-K Huynh, L Inandan, C Iglesias, I V Igumenshchev, N Izumi, M Jackson, J Jackson, S D Jacobs, G James, K Jancaitis, J Jarboe, L C Jarrott, D Jasion, J Jaquez, J Jeet, A E Jenei, J Jensen, J Jimenez, R Jimenez, D Jobe, Z Johal, H M Johns, D Johnson, M A Johnson, M Gatu Johnson, R J Johnson, S Johnson, S A Johnson, T Johnson, K Jones, O Jones, M Jones, R Jorge, H J Jorgenson, M Julian, B I Jun, R Jungquist, J Kaae, N Kabadi, D Kaczala, D Kalantar, K Kangas, V V Karasiev, M Karasik, V Karpenko, A Kasarky, K Kasper, R Kauffman, M I Kaufman, C Keane, L Keaty, L Kegelmeyer, P A Keiter, P A Kellett, J Kellogg, J H Kelly, S Kemic, A J Kemp, G E Kemp, G D Kerbel, D Kershaw, S M Kerr, T J Kessler, M H Key, S F Khan, H Khater, C Kiikka, J Kilkenny, Y Kim, Y-J Kim, J Kimko, M Kimmel, J M Kindel, J King, R K Kirkwood, L Klaus, D Klem, J L Kline, J Klingmann, G Kluth, P Knapp, J Knauer, J Knipping, M Knudson, D Kobs, J Koch, T Kohut, C Kong, J M Koning, P Koning, S Konior, H Kornblum, L B Kot, B Kozioziemski, M Kozlowski, P M Kozlowski, J Krammen, N S Krasheninnikova, B Kraus, W Krauser, J D Kress, A L Kritcher, E Krieger, J J Kroll, W L Kruer, M K G Kruse, S Kucheyev, M Kumbera, S Kumpan, J Kunimune, B Kustowski, T J T Kwan, G A Kyrala, S Laffite, M Lafon, K LaFortune, B Lahmann, B Lairson, O L Landen, J Langenbrunner, L Lagin, T Land, M Lane, D Laney, A B Langdon, S H Langer, A Langro, N E Lanier, T E Lanier, D Larson, B F Lasinski, D Lassle, D LaTray, G Lau, N Lau, C Laumann, A Laurence, T A Laurence, J Lawson, H P Le, R R Leach, L Leal, A Leatherland, K LeChien, B Lechleiter, A Lee, M Lee, T Lee, R J Leeper, E Lefebvre, J-P Leidinger, B LeMire, R W Lemke, N C Lemos, S Le Pape, R Lerche, S Lerner, S Letts, K Levedahl, T Lewis, C K Li, H Li, J Li, W Liao, Z M Liao, D Liedahl, J Liebman, G Lindford, E L Lindman, J D Lindl, H Loey, R A London, F Long, E N Loomis, F E Lopez, H Lopez, E Losbanos, S Loucks, R Lowe-Webb, E Lundgren, A P Ludwigsen, R Luo, J Lusk, R Lyons, T Ma, Y Macallop, M J MacDonald, B J MacGowan, J M Mack, A J Mackinnon, S A MacLaren, A G MacPhee, G R Magelssen, J Magoon, R M Malone, T Malsbury, R Managan, R Mancini, K Manes, D Maney, D Manha, O M Mannion, A M Manuel, E Mapoles, G Mara, T Marcotte, E Marin, M M Marinak, C Mariscal, D A Mariscal, E F Mariscal, E V Marley, J A Marozas, R Marquez, C D Marshall, F J Marshall, M Marshall, S Marshall, J Marticorena, D Martinez, I Maslennikov, D Mason, R J Mason, L Masse, W Massey, P-E Masson-Laborde, N D Masters, D Mathisen, E Mathison, J Matone, M J Matthews, C Mattoon, T R Mattsson, K Matzen, C W Mauche, M Mauldin, T McAbee, M McBurney, T Mccarville, R L McCrory, A M McEvoy, C McGuffey, M Mcinnis, P McKenty, M S McKinley, J B McLeod, A McPherson, B Mcquillan, M Meamber, K D Meaney, N B Meezan, R Meissner, T A Mehlhorn, N C Mehta, J Menapace, F E Merrill, B T Merritt, E C Merritt, D D Meyerhofer, S Mezyk, R J Mich, P A Michel, D Milam, C Miller, D Miller, D S Miller, E Miller, E K Miller, J Miller, M Miller, P E Miller, T Miller, W Miller, V Miller-Kamm, M Millot, J L Milovich, P Minner, J-L Miquel, S Mitchell, K Molvig, R C Montesanti, D S Montgomery, M Monticelli, A Montoya, J D Moody, A S Moore, E Moore, M Moran, J C Moreno, K Moreno, B E Morgan, T Morrow, J W Morton, E Moses, K Moy, R Muir, M S Murillo, J E Murray, J R Murray, D H Munro, T J Murphy, F M Munteanu, J Nafziger, T Nagayama, S R Nagel, R Nast, R A Negres, A Nelson, D Nelson, J Nelson, S Nelson, S Nemethy, P Neumayer, K Newman, M Newton, H Nguyen, J-M G Di Nicola, P Di Nicola, C Niemann, A Nikroo, P M Nilson, A Nobile, V Noorai, R Nora, M Norton, M Nostrand, V Note, S Novell, P F Nowak, A Nunez, R A Nyholm, M O'Brien, A Oceguera, J A Oertel, J Okui, B Olejniczak, J Oliveira, P Olsen, B Olson, K Olson, R E Olson, Y P Opachich, N Orsi, C D Orth, M Owen, S Padalino, E Padilla, R Paguio, S Paguio, J Paisner, S Pajoom, A Pak, S Palaniyappan, K Palma, T Pannell, F Papp, D Paras, T Parham, H-S Park, A Pasternak, S Patankar, M V Patel, P K Patel, R Patterson, S Patterson, B Paul, M Paul, E Pauli, O T Pearce, J Pearcy, B Pedrotti, A Peer, L J Pelz, B Penetrante, J Penner, A Perez, L J Perkins, E Pernice, T S Perry, S Person, D Petersen, T Petersen, D L Peterson, E B Peterson, J E Peterson, J L Peterson, K Peterson, R R Peterson, R D Petrasso, F Philippe, T J Phipps, E Piceno, Y Ping, L Pickworth, J Pino, R Plummer, G D Pollack, S M Pollaine, B B Pollock, D Ponce, J Ponce, J Pontelandolfo, J L Porter, J Post, O Poujade, C Powell, H Powell, G Power, M Pozulp, M Prantil, M Prasad, S Pratuch, S Price, K Primdahl, S Prisbrey, R Procassini, A Pruyne, B Pudliner, S R Qiu, K Quan, M Quinn, J Quintenz, P B Radha, F Rainer, J E Ralph, K S Raman, R Raman, P Rambo, S Rana, A Randewich, D Rardin, M Ratledge, N Ravelo, F Ravizza, M Rayce, A Raymond, B Raymond, B Reed, C Reed, S Regan, B Reichelt, V Reis, S Reisdorf, V Rekow, B A Remington, A Rendon, W Requieron, M Rever, H Reynolds, J Reynolds, J Rhodes, M Rhodes, M C Richardson, B Rice, N G Rice, R Rieben, A Rigatti, S Riggs, H G Rinderknecht, K Ring, B Riordan, R Riquier, C Rivers, D Roberts, V Roberts, G Robertson, H F Robey, J Robles, P Rocha, G Rochau, J Rodriguez, S Rodriguez, M Rosen, M Rosenberg, G Ross, J S Ross, P Ross, J Rouse, D Rovang, A M Rubenchik, M S Rubery, C L Ruiz, M Rushford, B Russ, J R Rygg, B S Ryujin, R A Sacks, R F Sacks, K Saito, T Salmon, J D Salmonson, J Sanchez, S Samuelson, M Sanchez, C Sangster, A Saroyan, J Sater, A Satsangi, S Sauers, R Saunders, J P Sauppe, R Sawicki, D Sayre, M Scanlan, K Schaffers, G T Schappert, S Schiaffino, D J Schlossberg, D W Schmidt, M J Schmitt, D H G Schneider, M B Schneider, R Schneider, M Schoff, M Schollmeier, M Schölmerich, C R Schroeder, S E Schrauth, H A Scott, I Scott, J M Scott, R H H Scott, C R Scullard, T Sedillo, F H Seguin, W Seka, J Senecal, S M Sepke, L Seppala, K Sequoia, J Severyn, J M Sevier, N Sewell, S Seznec, R C Shah, J Shamlian, D Shaughnessy, M Shaw, R Shaw, C Shearer, R Shelton, N Shen, M W Sherlock, A I Shestakov, E L Shi, S J Shin, N Shingleton, W Shmayda, M Shor, M Shoup, C Shuldberg, L Siegel, F J Silva, A N Simakov, B T Sims, D Sinars, P Singh, H Sio, K Skulina, S Skupsky, S Slutz, M Sluyter, V A Smalyuk, D Smauley, R M Smeltser, C Smith, I Smith, J Smith, L Smith, R Smith, R Sohn, S Sommer, C Sorce, M Sorem, J M Soures, M L Spaeth, B K Spears, S Speas, D Speck, R Speck, J Spears, T Spinka, P T Springer, M Stadermann, B Stahl, J Stahoviak, L G Stanton, R Steele, W Steele, D Steinman, R Stemke, R Stephens, S Sterbenz, P Sterne, D Stevens, J Stevers, C B Still, C Stoeckl, W Stoeffl, J S Stolken, C Stolz, E Storm, G Stone, S Stoupin, E Stout, I Stowers, R Strauser, H Streckart, J Streit, D J Strozzi, T Suratwala, G Sutcliffe, L J Suter, S B Sutton, V Svidzinski, G Swadling, W Sweet, A Szoke, M Tabak, M Takagi, A Tambazidis, V Tang, M Taranowski, L A Taylor, S Telford, W Theobald, M Thi, A Thomas, C A Thomas, I Thomas, R Thomas, I J Thompson, A Thongstisubskul, C B Thorsness, G Tietbohl, R E Tipton, M Tobin, N Tomlin, R Tommasini, A J Toreja, J Torres, R P J Town, S Townsend, J Trenholme, A Trivelpiece, C Trosseille, H Truax, D Trummer, S Trummer, T Truong, D Tubbs, E R Tubman, T Tunnell, D Turnbull, R E Turner, M Ulitsky, R Upadhye, J L Vaher, P VanArsdall, D VanBlarcom, M Vandenboomgaerde, R VanQuinlan, B M Van Wonterghem, W S Varnum, A L Velikovich, A Vella, C P Verdon, B Vermillion, S Vernon, R Vesey, J Vickers, R M Vignes, M Visosky, J Vocke, P L Volegov, S Vonhof, R Von Rotz, H X Vu, M Vu, D Wall, J Wall, R Wallace, B Wallin, D Walmer, C A Walsh, C F Walters, C Waltz, A Wan, A Wang, Y Wang, J S Wark, B E Warner, J Watson, R G Watt, P Watts, J Weaver, R P Weaver, S Weaver, C R Weber, P Weber, S V Weber, P Wegner, B Welday, L Welser-Sherrill, K Weiss, K Widmann, G F Wheeler, W Whistler, R K White, H D Whitley, P Whitman, M E Wickett, C Widmayer, J Wiedwald, R Wilcox, S Wilcox, C Wild, B H Wilde, C H Wilde, K Wilhelmsen, M D Wilke, H Wilkens, P Wilkins, S C Wilks, E A Williams, G J Williams, W Williams, W H Williams, D C Wilson, B Wilson, E Wilson, R Wilson, S Winters, J Wisoff, M Wittman, J Wolfe, A Wong, K W Wong, L Wong, N Wong, R Wood, D Woodhouse, J Woodruff, D T Woods, S Woods, B N Woodworth, E Wooten, A Wootton, K Work, J B Workman, J Wright, M Wu, C Wuest, F J Wysocki, H Xu, M Yamaguchi, B Yang, S T Yang, J Yatabe, C B Yeamans, B C Yee, S A Yi, L Yin, B Young, C S Young, C V Young, P Young, K Youngblood, R Zacharias, G Zagaris, N Zaitseva, F Zaka, F Ze, B Zeiger, M Zika, G B Zimmerman, T Zobrist, J D Zuegel, A B Zylstra
For more than half a century, researchers around the world have been engaged in attempts to achieve fusion ignition as a proof of principle of various fusion concepts. Following the Lawson criterion, an ignited plasma is one where the fusion heating power is high enough to overcome all the physical processes that cool the fusion plasma, creating a positive thermodynamic feedback loop with rapidly increasing temperature. In inertially confined fusion, ignition is a state where the fusion plasma can begin "burn propagation" into surrounding cold fuel, enabling the possibility of high energy gain...
August 12, 2022: Physical Review Letters
https://read.qxmd.com/read/35962234/comparative-effectiveness-of-dexamethasone-in-hospitalized-covid-19-patients-in-the-united-states
#32
JOURNAL ARTICLE
Casey Kar-Chan Choong, Mark Belger, Alisa E Koch, Kristin J Meyers, Vincent C Marconi, Hamed Abedtash, Douglas Faries, Venkatesh Krishnan
INTRODUCTION: To compare the mortality of hospitalized patients with COVID-19 between those that required supplemental oxygen and received dexamethasone with a comparable set of patients who did not receive dexamethasone. METHODS: We utilized the Premier Health Database to identify hospitalized adult patients with COVID-19 from July 1, 2020-January 31, 2021. Index date was when patients first initiated oxygen therapy. The primary endpoint was in-hospital mortality for patients receiving dexamethasone versus those not receiving dexamethasone 1-day pre- to 1-day post-index period...
August 12, 2022: Advances in Therapy
https://read.qxmd.com/read/35916540/comparison-of-accuracy-of-a-toric-calculator-with-predicted-versus-measured-posterior-corneal-astigmatism
#33
JOURNAL ARTICLE
Li Wang, Douglas D Koch
PURPOSE: To compare the accuracy of postoperative residual astigmatism prediction using the Barrett toric calculator with predicted versus measured posterior corneal astigmatism (PCA). SETTING: Cullen Eye Institute, Baylor College of Medicine, Houston, TX. DESIGN: Retrospective case series. METHODS: We included 602 eyes with monofocal non-toric IOL implantation. Biometry and PCA were obtained from the IOLMaster 700. Anticipated postoperative refractive astigmatism was calculated with the Barrett toric calculator for predicted and measured PCA, and the astigmatism prediction errors (PEs) for each were calculated using vector analysis...
August 1, 2022: Journal of Cataract and Refractive Surgery
https://read.qxmd.com/read/35857079/contemporary-statistical-analysis-of-refractive-error-in-adults-pseudophakia-and-refractive-surgery
#34
LETTER
Jack T Holladay, Rand R Wilcox, Douglas D Koch, Li Wang
No abstract text is available yet for this article.
November 1, 2022: Journal of Cataract and Refractive Surgery
https://read.qxmd.com/read/35749069/astigmatism-analysis-and-reporting-of-surgically-induced-astigmatism-and-prediction-error
#35
JOURNAL ARTICLE
Jack T Holladay, Rand R Wilcox, Douglas D Koch, Li Wang
PURPOSE: To provide a method for determining the vector that, when added to the preoperative astigmatism, results in no prediction error (PE) and to specify statistical methods for evaluating astigmatism and determining the 95% confidence convex polygon. SETTING: Baylor College of Medicine, Houston, Texas, and University of Southern California, Los Angeles, California. DESIGN: Retrospective consecutive case series. METHODS: An analysis of 3 clinical trials involving toric intraocular lenses was performed...
July 1, 2022: Journal of Cataract and Refractive Surgery
https://read.qxmd.com/read/35710755/screening-for-cd19-specific-chimaeric-antigen-receptors-with-enhanced-signalling-via-a-barcoded-library-of-intracellular-domains
#36
JOURNAL ARTICLE
Khloe S Gordon, Taeyoon Kyung, Caleb R Perez, Patrick V Holec, Azucena Ramos, Angela Q Zhang, Yash Agarwal, Yunpeng Liu, Catherine E Koch, Alina Starchenko, Brian A Joughin, Douglas A Lauffenburger, Darrell J Irvine, Michael T Hemann, Michael E Birnbaum
The immunostimulatory intracellular domains (ICDs) of chimaeric antigen receptors (CARs) are essential for converting antigen recognition into antitumoural function. Although there are many possible combinations of ICDs, almost all current CARs rely on combinations of CD3𝛇, CD28 and 4-1BB. Here we show that a barcoded library of 700,000 unique CD19-specific CARs with diverse ICDs cloned into lentiviral vectors and transduced into Jurkat T cells can be screened at high throughput via cell sorting and next-generation sequencing to optimize CAR signalling for antitumoural functions...
July 2022: Nature Biomedical Engineering
https://read.qxmd.com/read/35616507/clinical-outcomes-in-a-united-states-registration-study-of-a-novel-extended-depth-of-focus-intraocular-lens-with-a-nondiffractive-design
#37
JOURNAL ARTICLE
Cathleen McCabe, John Berdahl, Harvey Reiser, T Hunter Newsom, Lisa Cibik, Douglas Koch, Jessie Lemp-Hull, Srichand Jasti
PURPOSE: To evaluate the effectiveness and safety of the DFT015 intraocular lens (IOL) (AcrySof IQ Vivity Extended Vision), compared with an aspheric monofocal control IOL (AcrySof IQ model SN60WF). SETTING: Eleven investigation sites in the United States. DESIGN: Prospective, randomized, controlled clinical study. METHODS: Patients aged ≥22 years with bilateral cataracts were randomized to receive bilateral implantation of DFT015 or SN60WF...
May 26, 2022: Journal of Cataract and Refractive Surgery
https://read.qxmd.com/read/35557291/using-a-community-of-inquiry-in-the-design-of-histology-curriculum-for-first-year-medical-students
#38
JOURNAL ARTICLE
Leslie P McIntosh, Douglas Koch, Kerin Claeson, Marina D'Angelo
Histology faculty in the Doctor of Osteopathy (DO) program at the Philadelphia College of Osteopathic Medicine revised the delivery methodology of first-year histology content in order to improve student performance, increase social interaction among students and faculty, shift to an all-distance learning environment, and align curricula across our three campuses. This abstract describes an Action Research approach to implementing a Community of Inquiry (CoI) model of learning during a time of unprecedented change at both the program and the global level...
May 2022: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://read.qxmd.com/read/35556808/mitochondrial-grk2-is-a-novel-regulator-of-cardiac-energetics
#39
JOURNAL ARTICLE
Kimberly M Ferrero, Kurt Chuprun, Jessica Pfleger, Douglas Tilley, Erhe Gao, Walter J Koch
G protein-coupled receptor (GPCR) kinase 2 (GRK2) is highly expressed in the heart, where during injury or heart failure (HF), both its levels and activity increase. GRK2 is canonically studied in the context of GPCR phosphorylation; however, noncanonical activities of GRK2 have emerged and it is now appreciated that GRK2 has a large non-GPCR interactome. For example, in cardiac myocytes, GRK2 translocates from the cytosol to mitochondria (mtGRK2) following oxidative stress or ischemia injury, and this pool of mtGRK2 is associated with negative effects on metabolism and also induces myocyte cell death...
May 2022: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://read.qxmd.com/read/35483733/dapagliflozin-and-kidney-outcomes-in-hospitalized-patients-with-covid-19-infection-an-analysis-of-the-dare-19-randomized-controlled-trial
#40
JOURNAL ARTICLE
Hiddo J L Heerspink, Remo H M Furtado, Otavio Berwanger, Gary G Koch, Felipe Martinez, Omar Mukhtar, Subodh Verma, Samvel B Gasparyan, Fengming Tang, Sheryl L Windsor, Vicente Cés de Souza-Dantas, Mildren Del Sueldo, Robert Frankel, Ali Javaheri, Rafael A Maldonado, Caryn Morse, Marco Mota-Gomes, Douglas Shemin, Osvaldo Lourenço Silva, Alexandre Pereira Tognon, Marcel Twahirwa, Joan Buenconsejo, Russell Esterline, Jan Oscarsson, Philip Ambery, Anna Maria Langkilde, Mikhail N Kosiborod
BACKGROUND AND OBJECTIVES: Patients who were hospitalized with coronavirus disease 2019 (COVID-19) infection are at high risk of AKI and KRT, especially in the presence of CKD. The Dapagliflozin in Respiratory Failure in Patients with COVID-19 (DARE-19) trial showed that in patients hospitalized with COVID-19, treatment with dapagliflozin versus placebo resulted in numerically fewer participants who experienced organ failure or death, although these differences were not statistically significant...
April 28, 2022: Clinical Journal of the American Society of Nephrology: CJASN
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