Riccardo V Mancuso, Gisbert Schneider, Marianne Hürzeler, Martin Gut, Jonas Zurflüh, Werner Breitenstein, Jamal Bouitbir, Felix Reisen, Kenneth Atz, Claus Ehrhardt, Urs Duthaler, Daniel Gygax, Albrecht G Schmidt, Stephan Krähenbühl, Gabriele Weitz-Schmidt
Integrins are a family of cell surface receptors well-recognized for their therapeutic potential in a wide range of diseases. However, the development of integrin targeting medications has been impacted by unexpected downstream effects, reflecting originally unforeseen interference with the bidirectional signalling and cross-communication of integrins. We here selected one of the most severely affected target integrins, the integrin lymphocyte function-associated antigen-1 (LFA-1, αL β2 , CD11a/CD18), as a prototypic integrin to systematically assess and overcome these known shortcomings...
March 13, 2023: Biochemical Pharmacology