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https://www.readbyqxmd.com/read/28514313/clinical-and-biological-correlations-in-celiac-disease-in-children-the-prospective-single-experience-of-a-romanian-tertiary-center-a-case-control-study-strobe-compliant-study
#1
Cristina Oana Marginean, Lorena Elena Meliţ, Roxana-Cristina Mareş, Maria Oana Mărginean, Septimiu Voidăzan, Minodora Dobreanu
Celiac disease-a chronic inflammatory disease of the intestine-is triggered by gluten or associated protein consumption.The aim of our study was to assess the sensitivity, specificity of the combined anti-transglutaminase 2 (TG2)/deamidated gliadin peptide antibodies (DGP), and antiendomisium antibodies (EMA), to determine the distribution of HLA-DQ2/DQ8 for the 140 tested patients, and also to evaluate the clinical and laboratory characteristics of patients admitted with the suspicion of celiac disease (CD)...
May 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28513748/development-of-stable-pickering-emulsions-oil-powders-and-pickering-hipes-stabilized-by-gliadin-chitosan-complex-particles
#2
D B Yuan, Y Q Hu, T Zeng, S W Yin, C H Tang, X Q Yang
In this paper, we demonstrate the use of gliadin/chitosan complex particles (GCCPs) as particulate stabilizers of oil-in-water emulsions of natural oils and water. For this purpose, we fabricated GCCPs through a facile anti-solvent procedure and demonstrated their usage in the formation of Pickering emulsions and Pickering high internal phase emulsions (HIPEs). The GCCPs can be used to produce surfactant-free o/w Pickering emulsions and Pickering HIPEs; unfortunately these emulsions were labile to coalescence...
May 17, 2017: Food & Function
https://www.readbyqxmd.com/read/28511837/immunomodulatory-activity-of-recombinant-%C3%AE-gliadin-conjugated-to-cholera-toxin-in-dq8-transgenic-mice
#3
Stefano Rossi, Diomira Luongo, Francesco Maurano, Paolo Bergamo, Mauro Rossi
Coeliac disease (CD) is characterized by an intestinal lesion sustained by an abnormal mucosal T-cell response to wheat gliadin. An immunological approach that is able to suppress this immune response is a perspective worth pursuing. Several strategies of antigen administration have been aimed at the downregulation of pathogenic T-cells. In particular, we previously reported a significant suppression of the systemic cell-mediated response toward wheat gliadin in DQ8 transgenic mice receiving nasally a recombinant α-gliadin...
May 13, 2017: Immunology Letters
https://www.readbyqxmd.com/read/28505469/the-association-between-immune-markers-and-recent-suicide-attempts-in-patients-with-serious-mental-illness-a-pilot-study
#4
Faith Dickerson, Maria Adamos, Emily Katsafanas, Sunil Khushalani, Andrea Origoni, Christina Savage, Lucy Schweinfurth, Cassie Stallings, Kevin Sweeney, Armin Alaedini, Melanie Uhde, Emily Severance, Holly C Wilcox, Robert Yolken
Previous studies have identified elevations in markers of gastrointestinal inflammation in schizophrenia and mood disorders but studies have not measured the association between these markers and recent suicide attempts. We assessed 210 patients receiving treatment for schizophrenia, bipolar disorder, or major depression. We employed the Columbia Suicide Severity Rating Scale to identify recent and lifetime suicide attempts (actual, aborted, and interrupted). Psychiatric participants and a control group of 72 individuals without a psychiatric disorder had a blood sample drawn from which were measured specific markers of gastrointestinal inflammation and also C-Reactive protein (CRP)...
May 9, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28500039/selected-probiotic-lactobacilli-have-the-capacity-to-hydrolyze-gluten-peptides-during-simulated-gastro-intestinal-digestion
#5
Ruggiero Francavilla, Maria De Angelis, Carlo Giuseppe Rizzello, Noemi Cavallo, Fabio Dal Bello, Marco Gobbetti
The aim of this study was to demonstrate the capacity of probiotic lactobacilli to hydrolyze immunogenic gluten peptides. Eighteen commercial strains of probiotic lactobacilli with highly variable peptidase activity (i.e., aminopeptidase N, iminopeptidase, prolyl endopeptidyl peptidase, tripeptidase, prolidase, prolinase and dipeptidase), including towards Pro-rich peptides, were tested in this study. Ten probiotic strains were selected based on their specific enzyme activity. When pooled, these ten strains provide the peptidase portfolio that is required to completely degrade the immunogenic gluten peptides involved in celiac disease (CD)...
May 12, 2017: Applied and Environmental Microbiology
https://www.readbyqxmd.com/read/28496327/anorexia-nervosa-of-the-restrictive-type-and-celiac-disease-in-adolescence
#6
Renata Nacinovich, Lucio Tremolizzo, Fabiola Corbetta, Elisa Conti, Francesca Neri, Monica Bomba
BACKGROUND: Anorexia nervosa (AN) is usually present in adolescence with symptoms partially overlapping celiac disease (CD), but the relationship between these two conditions has received little attention in the literature. The aim of this work was to explore this relationship, considering if CD could be associated with specific baseline AN-related clinical features. METHODS: In this retrospective study, 82 adolescent female out- and inpatients with AN of the restrictive type (ANr), according to the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition criteria, were recruited...
2017: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/28489059/the-impact-of-diet-wheat-source-on-the-onset-of-type-1-diabetes-mellitus-lessons-learned-from-the-non-obese-diabetic-nod-mouse-model
#7
Jonathan Gorelick, Ludmila Yarmolinsky, Arie Budovsky, Boris Khalfin, Joshua D Klein, Yosi Pinchasov, Maxim A Bushuev, Tatiana Rudchenko, Shimon Ben-Shabat
Nutrition, especially wheat consumption, is a major factor involved in the onset of type 1 diabetes (T1D) and other autoimmune diseases such as celiac. While modern wheat cultivars possess similar gliadin proteins associated with the onset of celiac disease and T1D, alternative dietary wheat sources from Israeli landraces and native ancestral species may be lacking the epitopes linked with T1D, potentially reducing the incidence of T1D. The Non-Obese Diabetic (NOD) mouse model was used to monitor the effects of dietary wheat sources on the onset and development of T1D...
May 10, 2017: Nutrients
https://www.readbyqxmd.com/read/28485731/differential-antibody-responses-to-gliadin-derived-indigestible-peptides-in-patients-with-schizophrenia
#8
R T McLean, P Wilson, D St Clair, C J Mustard, J Wei
Gluten consumption has previously been implicated in the development of schizophrenia while an immunological link between gluten and schizophrenia was established by the detection of circulating antibodies against gliadin, a major component of wheat gluten. Several studies have reported an increase in circulating antibodies against native gliadin molecules that are unlikely to survive degradation in the digestive system. In this study, therefore, we measured plasma immunoglobulin G (IgG) and IgA antibodies against indigestible gliadin-derived peptide antigens using an in-house enzyme-linked immunosorbent assay (ELISA) among 169 patients with schizophrenia and 236 control subjects...
May 9, 2017: Translational Psychiatry
https://www.readbyqxmd.com/read/28481518/information-visualization-and-feature-selection-methods-applied-to-detect-gliadin-in-gluten-containing-foodstuff-with-a-microfluidic-electronic-tongue
#9
Cristiane Margarete Daikuzono, Flavio Makoto Shimizu, Alexandra Manzoli, Antonio Riul, Maria Helena de Oliveira Piazzetta, Angelo Luiz Gobbi, Daniel S Correa, Fernando V Paulovich, Osvaldo Novais Oliveira
The fast growth of celiac disease diagnosis has sparked the production of gluten-free food and the search for reliable methods to detect gluten in foodstuff. In this paper, we report on a microfluidic electronic tongue (e-tongue) capable of detecting trace amounts of gliadin, a protein of gluten, down to 0.005 mg.kg(-1) in ethanol solutions, and distinguishing between gluten-free and gluten-containing foodstuff. In some cases it is even possible to determine whether gluten-free foodstuff has been contaminated with gliadin...
May 8, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28479483/coffee-and-autoimmunity-more-than-a-mere-hot-beverage
#10
REVIEW
Kassem Sharif, Abdulla Watad, Nicola Luigi Bragazzi, Mohammad Adawi, Howard Amital, Yehuda Shoenfeld
Coffee is one of the world's most consumed beverage. In the last decades, coffee consumption has attracted a huge body of research due to its impact on health. Recent scientific evidences showed that coffee intake could be associated with decreased mortality from cardiovascular and neurological diseases, diabetes type II, as well as from endometrial and liver cancer, among others. In this review, on the basis of available data in the literature, we aimed to investigate the association between coffee intake and its influence on the immune system and the insurgence of the most relevant autoimmune diseases...
May 4, 2017: Autoimmunity Reviews
https://www.readbyqxmd.com/read/28472326/novel-insights-into-the-effect-of-nitrogen-on-storage-protein-biosynthesis-and-protein-body-development-in-wheat-caryopsis
#11
Xurun Yu, Xinyu Chen, Leilei Wang, Yang Yang, Xiaowei Zhu, Shanshan Shao, Wenxue Cui, Fei Xiong
Molecular and cytological mechanisms concerning the effects of nitrogen on wheat (Triticum aestivum L.) storage protein biosynthesis and protein body development remain largely elusive. We used transcriptome sequencing, proteomics techniques, and light microscopy to investigate these issues. In total, 2585 differentially expressed genes (DEGs) and 57 differentially expressed proteins (DEPs) were found 7 days after anthesis (DAA), and 2456 DEGs and 64 DEPs were detected 18 DAA after nitrogen treatment. Gene ontology terms related to protein biosynthesis processes enriched these numbers by 678 and 582 DEGs at 7 and 18 DAA, respectively...
May 4, 2017: Journal of Experimental Botany
https://www.readbyqxmd.com/read/28461188/validation-of-antibody-based-strategies-for-diagnosis-of-pediatric-celiac-disease-without-biopsy
#12
Johannes Wolf, David Petroff, Thomas Richter, Marcus Kh Auth, Holm H Uhlig, Martin W Laass, Peter Lauenstein, Andreas Krahl, Norman Händel, Jan de Laffolie, Almuthe C Hauer, Thomas Kehler, Gunter Flemming, Frank Schmidt, Astor Rodriques, Dirk Hasenclever, Thomas Mothes
BACKGROUND AND AIMS: A diagnosis of celiac disease is made based on clinical, genetic, serologic, and duodenal morphology features. Recent pediatric guidelines, based largely on retrospective data, propose omitting biopsy analysis for patients with concentrations of immunoglobulin A against tissue transglutaminase (IgA-TTG) more than 10-fold the upper limit of normal (ULN) and if further criteria are met. A retrospective study concluded that measurements of IgA-TTG and total IgA, or IgA-TTG and IgG against deamidated gliadin (IgG-DGL) could identify patients with and without celiac disease...
April 28, 2017: Gastroenterology
https://www.readbyqxmd.com/read/28450003/protein-interactions-during-flour-mixing-using-wheat-flour-with-altered-starch
#13
Xiaolong Wang, Rudi Appels, Xiaoke Zhang, Dean Diepeveen, Kitti Torok, Sandor Tomoskozi, Ferenc Bekes, Wujun Ma, Peter Sharp, Shahidul Islam
Wheat grain proteins responses to mixing and thermal treatment were investigated using Mixolab-dough analysis systems with flour from two cultivars, Ventura-26 (normal amylose content) and Ventura-19 (reduced amylose content). Size exclusion high performance liquid chromatography (SE-HPLC) and two-dimensional gel electrophoresis (2-DGE) analysis revealed that, stress associated and metabolic proteins largely interacted with dough matrix of Ventura-26 after 26min (56°C); gliadins, avenin-like b proteins, LMW-GSs, and partial globulins showed stronger interactions within the dough matrix of Ventura-26 at 32min/C3 (80°C), thereafter, however, stronger protein interactions were observed within the dough matrix of Ventura-19 at 38min/C4 (85°C) and 43min (80°C)...
September 15, 2017: Food Chemistry
https://www.readbyqxmd.com/read/28449988/development-of-antioxidant-pickering-high-internal-phase-emulsions-hipes-stabilized-by-protein-polysaccharide-hybrid-particles-as-potential-alternative-for-phos
#14
Tao Zeng, Zi-Ling Wu, Jun-You Zhu, Shou-Wei Yin, Chuan-He Tang, Lei-Yan Wu, Xiao-Quan Yang
We report for the first time the usage of mono-dispersed gliadin/chitosan hybrid particles as a particulate emulsifier for Pickering high internal phase emulsions (HIPEs) development. The hybrid particles with partial wettability were fabricated at pH 5.0 using a facile anti-solvent route. Stable Pickering HIPEs with internal phases of up to 83% can be prepared with low particle concentrations (0.5-2%). The hybrid latexes were effectively adsorbed and anchored at the oil-water interface to exert steric hindrance against coalescence...
September 15, 2017: Food Chemistry
https://www.readbyqxmd.com/read/28443584/is-the-diagnosis-of-celiac-disease-possible-without-intestinal-biopsy
#15
Maha Shomaf, Mohammad Rashid, Dana Faydi, Ahmad Halawa
BACKGROUND: Celiac disease, is defined as a state of immune mediated hyper responsiveness to dietary gluten as wheat, barley, or rye in genetically predisposed individuals, resulting in tissue damage. It affects approximately 1% of populations worldwide. The diagnosis is done by microscopic examination of small intestinal biopsy, although serologic testing for antibodies against tissue transglutaminase (tTG) and deamidated gliadin peptide can be of great advantage. It has been suggested that duodenal biopsy can be avoided in patients with high levels of tTG antibody since a relationship was found to be present between tTG antibody titers and celiac disease...
April 6, 2017: Balkan Medical Journal
https://www.readbyqxmd.com/read/28434263/plant-protein-based-hydrophobic-fine-and-ultrafine-carrier-particles-in-drug-delivery-systems
#16
Hedieh Malekzad, Hamed Mirshekari, Parham Sahandi Zangabad, S M Moosavi Basri, Fazel Baniasadi, Maryam Sharifi Aghdam, Mahdi Karimi, Michael R Hamblin
For thousands of years, plants and their products have been used as the mainstay of medicinal therapy. In recent years, besides attempts to isolate the active ingredients of medicinal plants, other new applications of plant products, such as their use to prepare drug delivery vehicles, have been discovered. Nanobiotechnology is a branch of pharmacology that can provide new approaches for drug delivery by the preparation of biocompatible carrier nanoparticles (NPs). In this article, we review recent studies with four important plant proteins that have been used as carriers for targeted delivery of drugs and genes...
April 24, 2017: Critical Reviews in Biotechnology
https://www.readbyqxmd.com/read/28433781/prevalence-of-celiac-disease-autoimmunity-among-adolescents-and-young-adults-in-china
#17
Juanli Yuan, Chunyan Zhou, Jinyan Gao, Jingjing Li, Fenglian Yu, Jun Lu, Xin Li, Xiaozhong Wang, Ping Tong, Zhihua Wu, Anshu Yang, Yonghong Yao, Sarah Nadif, Heng Shu, Jiang Xu, Yujie Wu, Luud Gilissen, Hongbing Chen
BACKGROUND & AIMS: In China, epidemiological information on celiac disease autoimmunity is scarce and fragmented. We investigated the prevalence of celiac disease autoimmunity in the general Chinese population. METHODS: In a cross-sectional prospective study, 19,778 undiagnosed Chinese adolescents and young adults (16-25 years old) were recruited from consecutive new students who underwent routine physical examinations at 2 universities in Jiangxi, China from Sep...
April 19, 2017: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28406045/a-methacrylic-hyaluronic-acid-derivative-for-potential-application-in-oral-treatment-of-celiac-disease
#18
Giovanna Pitarresi, Fabio Salvatore Palumbo, Daniela Triolo, Calogero Fiorica, Gaetano Giammona
OBJECTIVE: Aim of this work was the synthesis of a methacrylic hyaluronic acid derivative and the production, via photocrosslinking, of related hydrogels loaded with an endopeptidase intended for a potential oral treatment of celiac disease. METHODS: The methacrylic derivative of hyaluronic acid (HA) was prepared through a one-pot procedure involving the reaction with ethylenediamine (EDA) and methacrylic anhydride (MA). The obtained derivative, named HA-EDA-MA, was used to prepare photocrosslinked hydrogels loaded with a prolyl endopeptidase derived from Flavobacterium meningosepticum (PEP FM) able to detoxify gliadin...
April 13, 2017: Drug Development and Industrial Pharmacy
https://www.readbyqxmd.com/read/28397343/celiac-disease-prevalence-in-a-large-series-of-patients-with-behcet-s-disease
#19
Erdem Koçak, Erdem Akbal, Yavuz Beyazit, Bilal Ergül, Arzu Karataş, Seyfettin Köklü, H Meral Ekşioğlu
AIM: There are common findings between Behçet's disease (BD) and celiac disease (CD) based on similar immunological pathogenesis and there is only limited data available investigating the link between these two diseases. Furthermore, documented gastrointestinal (GI) involvement with marked upper GI symptoms in BD has been rarely reported. The aim of this study was to assess the prevalence of CD and to evaluate endoscopic findings in Turkish BD patients. METHODS: A total of 210 BD patients were included in the study...
April 11, 2017: International Journal of Rheumatic Diseases
https://www.readbyqxmd.com/read/28393621/a-review-on-the-relationship-between-gluten-and-schizophrenia-is-gluten-the-cause
#20
Can Ergün, Murat Urhan, Ahmet Ayer
INTRODUCTION: Schizophrenia is a chronic disease that possesses various clinical manifestations. It presents rather heterogeneous characteristics with respect to onset type, symptoms, and the course of the disease. Although the lifetime prevalence is as low as 1%, it can cause serious disability. Thus, it is very important to develop efficient treatment methods. In some studies, it is hypothesized that removing gluten from the diet leads to a significant improvement in disease symptoms...
April 9, 2017: Nutritional Neuroscience
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