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https://www.readbyqxmd.com/read/28103389/the-use-of-antioxidants-in-the-treatment-of-traumatic-brain-injury
#1
Whitney Venegoni, Qiuhua Shen, Amanda R Thimmesch, Meredith Bell, John B Hiebert, Janet D Pierce
AIMS: To discuss secondary traumatic brain injury, the mitochondria and the use of antioxidants as a treatment. BACKGROUND: One of the leading causes of death in young adults internationally is traumatic brain injury, affecting individuals in all demographics. Traumatic brain injury is produced by an external blunt force or penetration resulting in alterations in brain function or pathology. Often, with a traumatic brain injury, secondary injury causes additional damage to the brain tissue that can have further impact on recovery and the quality of life...
January 19, 2017: Journal of Advanced Nursing
https://www.readbyqxmd.com/read/28099951/complex-x-chromosomal-rearrangements-in-two-women-with-ovarian-dysfunction-implications-of-chromothripsis-chromoanasynthesis-dependent-and-independent-origins-of-complex-genomic-alterations
#2
Erina Suzuki, Hirohito Shima, Machiko Toki, Kunihiko Hanew, Keiko Matsubara, Hiroki Kurahashi, Satoshi Narumi, Tsutomu Ogata, Tsutomu Kamimaki, Maki Fukami
Our current understanding of the phenotypic consequences and the molecular basis of germline complex chromosomal rearrangements remains fragmentary. Here, we report the clinical and molecular characteristics of 2 women with germline complex X-chromosomal rearrangements. Patient 1 presented with nonsyndromic ovarian dysfunction and hyperthyroidism; patient 2 exhibited various Turner syndrome- associated symptoms including ovarian dysfunction, short stature, and autoimmune hypothyroidism. The genomic abnormalities of the patients were characterized by array-based comparative genomic hybridization, high-resolution karyotyping, microsatellite genotyping, X-inactivation analysis, and bisulfite sequencing...
January 19, 2017: Cytogenetic and Genome Research
https://www.readbyqxmd.com/read/28099869/amitriptyline-down-regulates-coenzyme-q10-biosynthesis-in-lung-cancer-cells
#3
Tamara Ortiz, Marina Villanueva-Paz, Eduardo Díaz-Parrado, Matilde Illanes, Ana Fernández-Rodríguez, José A Sánchez-Alcázar, Manuel de Miguel
Amitriptyline, a tricyclic antidepressant, has been proposed as an antitumoral drug in oxidative therapy. Its pro-apoptotic effects, mediated by high reactive oxygen species generation, have been already described. In this study we analysed the effect of amitriptyline on the biosynthesis of coenzyme Q10 (CoQ), an essential component for electron transport and a potent membrane antioxidant involved in redox signaling. We treated H460 cells, a non-small-cell lung cancer cell line, with amitriptyline and we analyzed CoQ levels by HPLC and CoQ biosynthesis rate, as well as the enzymes involved in CoQ biosynthesis by real-time PCR and Western blot...
January 15, 2017: European Journal of Pharmacology
https://www.readbyqxmd.com/read/28077390/reversible-temperature-dependent-differences-in-brown-adipose-tissue-respiration-during-torpor-in-a-mammalian-hibernator
#4
Sarah Victoria McFarlane, Katherine E Mathers, James F Staples
While seasonal modifications of brown adipose tissue (BAT) in hibernators are well documented, we know little about functional regulation of BAT in different phases of hibernation. In the 13-lined ground squirrel, liver mitochondrial respiration is suppressed by up to 70% during torpor. This suppression is reversed during arousal an°°d interbout euthermia (IBE), and corresponds with patterns of maximal activities of electron transport system (ETS) enzymes. Uncoupling of BAT mitochondria is controlled by free-fatty acid release stimulated by sympathetic activation of adipocytes, so we hypothesized that further regulation at the level of the ETS would be of little advantage...
January 11, 2017: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
https://www.readbyqxmd.com/read/28074262/activated-microglia-induce-the-production-of-reactive-oxygen-species-and-promote-apoptosis-of-co-cultured-retinal-microvascular-pericytes
#5
Xinyi Ding, Meng Zhang, Ruiping Gu, Gezhi Xu, Haixiang Wu
PURPOSE: Pericyte apoptosis is a predominant feature of early diabetic retinopathy. In diabetic retinopathy, activated microglia migrate and release proinflammatory cytokines that contribute to disruption of the blood-retinal barrier, neuronal loss, and enhanced ROS production. Reactive oxygen species (ROS) are implicated in pericyte death; however, the mechanism by which activated microglia affect retinal microvascular pericytes is unclear. We hypothesized that activated microglia may promote pericyte apoptosis by enhancing ROS production...
January 10, 2017: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/28069357/control-strategies-for-drug-product-continuous-direct-compression-state-of-control-product-collection-strategies-and-startup-shutdown-operations-for-the-production-of-clinical-trial-materials-and-commercial-products
#6
Ahmad Almaya, Lawrence De Belder, Robert Meyer, Karthik Nagapudi, Hung-Ren Homer Lin, Ian Leavesley, Jayanthy Jayanth, Gurjit Bajwa, James DiNunzio, Anthony Tantuccio, Dan Blackwood, Admassu Abebe
Continuous Manufacturing (CM) has emerged in the pharmaceutical industry as a paradigm shift with significant advantages related to cost, efficiency, flexibility and higher assurance of quality. The inherent differences from batch processes justify examining the CM control strategy more holistically. This paper describes the current thinking for the control and implementation of CM, using the example of a direct compression process and taking into consideration the ICH Q10 definition of "state of control" and process validation requirements...
January 6, 2017: Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28062644/ligand-induced-conformational-changes-in-prolyl-oligopeptidase-a-kinetic-approach
#7
R Van Elzen, E Schoenmakers, I Brandt, P Van Der Veken, A M Lambeir
Most kinetic studies of prolyl oligopeptidase (PREP) were performed with the porcine enzyme using modified peptide substrates. Yet recent biophysical studies used the human homolog. Therefore, the aim of this study was to compare the kinetic behavior of human and porcine PREP, as well as to find a suitable method to study enzyme kinetics with an unmodified biological substrate. It was found that human PREP behaves identically to the porcine homolog, displaying a double bell-shaped pH profile and a pH-dependent solvent kinetic isotope effect of the kcat/Km, features that set it apart from the related exopeptidase dipeptidyl peptidase IV (DPP IV)...
January 5, 2017: Protein Engineering, Design & Selection: PEDS
https://www.readbyqxmd.com/read/28058114/protective-effects-of-co-enzyme-q10-on-thioacetamide-induced-acute-liver-damage-and-its-correlation-with-behavioral-biochemical-and-pathological-factors
#8
Soheil Ashkani-Esfahani, Fereshteh Bagheri, Yasaman Emami, Elmira Esmaeilzadeh, Negar Azarpira, Nazila Hassanabadi, Marzieh Keshtkar, Mojtaba Farjam, Omid Koohi-Hosseinabadi, Ali Noorafshan
BACKGROUND: Acute liver damage may be followed by biochemical, behavioral, and pathological alterations, which can result in serious complications and even death. OBJECTIVES: In this experimental study we determined whether coenzyme Q10 (CoQ10), a common supplementary medicine known to have protective, antioxidative, and anti-inflammatory effects in cells, has any protective effect against thioacetamide (TAA)-induced liver damage and its related neurobehavioral alterations in rats...
August 2016: Iranian Red Crescent Medical Journal
https://www.readbyqxmd.com/read/28055123/regional-variation-in-the-temperature-sensitivity-of-soil-organic-matter-decomposition-in-china-s-forests-and-grasslands
#9
Yuan Liu, Nianpeng He, Jianxing Zhu, Li Xu, Guirui Yu, Shuli Niu, Xiaomin Sun, Xuefa Wen
How to assess the temperature sensitivity (Q10 ) of soil organic matter (SOM) decomposition and its regional variation with high accuracy is one of the largest uncertainties in determining the intensity and direction of the global carbon (C) cycle in response to climate change. In this study, we collected a series of soils from 22 forest sites and 30 grassland sites across China to explore regional variation in Q10 and its underlying mechanisms. We conducted a novel incubation experiment with periodically changing temperature (5-30 °C), while continuously measuring soil microbial respiration rates...
January 5, 2017: Global Change Biology
https://www.readbyqxmd.com/read/28054958/coenzyme-q10-and-oxidative-stress-inflammation-status-in-hepatocellular-carcinoma-patients-after-surgery
#10
Hsiao-Tien Liu, Shao-Bin Cheng, Yi-Chia Huang, Yin-Tzu Huang, Ping-Ting Lin
(1) Background: Hepatocellular carcinoma (HCC) is the second leading cause of cancer deaths worldwide, and surgical resection is the main treatment for HCC. To date, no published study has examined the status of coenzyme Q10 in patients with HCC after surgery. Thus, the purpose of this study was to investigate the correlations between the level of coenzyme Q10, oxidative stress, and inflammation in patients with HCC after surgery; (2) Methods: 71 primary HCC patients were recruited. Levels of coenzyme Q10, vitamin E, oxidative stress (malondialdehyde), antioxidant enzymes activity (superoxidase dismutase, catalase, and glutathione peroxidase), and inflammatory markers (high sensitivity C-reactive protein; tumor necrosis factor-α; and interleukin-6) were measured; (3) Results: Patients with HCC had a significantly lower levels of coenzyme Q10 (p = 0...
January 4, 2017: Nutrients
https://www.readbyqxmd.com/read/28050757/implication-of-nrf2-ho-1-pathway-in-the-coloprotective-effect-of-coenzyme-q10-against-experimentally-induced-ulcerative-colitis
#11
Ahmed E Khodir, Hoda Atef, Eman Said, Hassan A ElKashef, Hatem A Salem
PURPOSE: Given the increased incidence of ulcerative colitis worldwide, the current study was designed to investigate the coloprotective potential of CoQ10 against experimentally induced ulcerative colitis (UC) and specify the implicated mechanisms. METHODS: Ulcerative colitis was induced by intracolonic instillation of [2 ml, 3% v/v acetic acid (AA)]. Rats in the different experimental groups received CoQ10 (10 or 30 and 100 mg/kg, orally) for eight consecutive days, either in a protective or curative regimen...
January 3, 2017: Inflammopharmacology
https://www.readbyqxmd.com/read/28035154/comparison-of-the-oxidative-stability-of-linseed-linum-usitatissimum-l-oil-by-pressure-differential-scanning-calorimetry-and-rancimat-measurements
#12
Edyta Symoniuk, Katarzyna Ratusz, Krzysztof Krygier
The aim of this study was to compare the oxidative stability of linseed oil using the pressure differential scanning calorimetry (PDSC) and Rancimat methods, and to determine the kinetic parameters of linseed oil oxidation. Five cold pressed linseed oils were oxidized at different temperatures under PDSC (90-140 °C) and Rancimat (70-140 °C) test conditions. The oxidative stability of the linseed oils was calculated based on induction times (PDSCτmax, Rancimat τon), the Arrhenius equation and activated complex theory, frequency factors (Z), the reaction rate coefficient (k) for all temperatures, activation energies (Ea), Q10 numbers, activation enthalpies (∆H(++)), and activation entropies (∆S(++))...
November 2016: Journal of Food Science and Technology
https://www.readbyqxmd.com/read/27998714/a-nutraceutical-approach-armolipid-plus-to-reduce-total-and-ldl-cholesterol-in-individuals-with-mild-to-moderate-dyslipidemia-review-of-the-clinical-evidence
#13
Vivencio Barrios, Carlos Escobar, Arrigo Francesco Giuseppe Cicero, David Burke, Peter Fasching, Maciej Banach, Eric Bruckert
Compelling evidence supports the effectiveness of the reduction of total and LDL cholesterol (TC and LDL-C) in primarily preventing cardiovascular events, within the framework of life-long prevention programs mainly consisting in lifestyle changes. Pharmacological treatment should be introduced when lifestyle changes, including use of nutraceuticals, have failed. ESC/EAS guidelines list a number of nutraceutical compounds and functional foods which have been individually studied in randomized, controlled clinical trials (RCTs)...
February 2017: Atherosclerosis. Supplements
https://www.readbyqxmd.com/read/27992576/temperature-sensitivity-of-soil-respiration-to-nitrogen-fertilization-varying-effects-between-growing-and-non-growing-seasons
#14
Qingfang Liu, Rui Wang, Rujian Li, Yaxian Hu, Shengli Guo
Nitrogen (N) fertilization has a considerable effect on food production and carbon cycling in agro-ecosystems. However, the impacts of N fertilization rates on the temperature sensitivity of soil respiration (Q10) were controversial. Five N rates (N0, N45, N90, N135, and N180) were applied to a continuous winter wheat (Triticum aestivum L.) crop on the semi-arid Loess Plateau, and the in situ soil respiration was monitored during five consecutive years from 2008 to 2013. During the growing season, the mean soil respiration rates increased with increasing N fertilization rates, peaking at 1...
2016: PloS One
https://www.readbyqxmd.com/read/27979285/automatic-determination-of-coenzyme-q10-in-food-using-cresyl-violet-encapsulated-into-magnetoliposomes
#15
Vanessa Román-Pizarro, Juan Manuel Fernández-Romero, Agustina Gómez-Hens
A new type of magnetoliposomes (MLs), containing hydrophobic magnetic-gold nanoparticles and the long wavelength fluorophore cresyl violet, has been used for the determination of coenzyme Q10 (CoQ10). MLs were concentrated just before the detector, using a flow system and an external electromagnet device. The subsequent introduction of Triton X-100 and CoQ10 causes the MLs lysis and the cresyl violet oxidation, obtaining a decrease in the fluorescence signal. The dynamic range of the calibration graph was 0...
April 15, 2017: Food Chemistry
https://www.readbyqxmd.com/read/27974651/consistent-leaf-respiratory-response-to-experimental-warming-of-three-north-american-deciduous-trees-a-comparison-across-seasons-years-habitats-and-sites
#16
Xiaorong Wei, Kerrie M Sendall, Artur Stefanski, Changming Zhao, Jihua Hou, Roy L Rich, Rebecca A Montgomery, Peter B Reich
Most vascular plants acclimate respiration to changes in ambient temperature, but explicit tests of these responses in field settings are rare, and how acclimation responses vary in space and time is relatively unstudied, hindering our ability to predict respiratory release of carbon under future climatic conditions. We measured temperature response curves of leaf respiration for three deciduous tree species from 2009 to 2012 in a field warming experiment (+3.4 °C above ambient) in both open and understory conditions at two sites in the southern boreal forest in Minnesota, USA...
December 14, 2016: Tree Physiology
https://www.readbyqxmd.com/read/27942805/low-circulating-coenzyme-q10-during-acute-phase-is-associated-with-inflammation-malnutrition-and-in-hospital-mortality-in-patients-admitted-to-the-coronary-care-unit
#17
Megumi Shimizu, Tetsuro Miyazaki, Atsutoshi Takagi, Yurina Sugita, Shoichiro Yatsu, Azusa Murata, Takao Kato, Shoko Suda, Shohei Ouchi, Tatsuro Aikawa, Masaru Hiki, Shuhei Takahashi, Makoto Hiki, Hidemori Hayashi, Takatoshi Kasai, Kazunori Shimada, Katsumi Miyauchi, Hiroyuki Daida
Coenzyme Q10 (CoQ10) has a potential role in the prevention and treatment of heart failure through improved cellular bioenergetics. In addition, it has antioxidant, free radical scavenging, and vasodilatory effects that may be beneficial. Although critical illness in intensive care unit is associated with decreased circulating CoQ10 levels, the clinical significance of CoQ10 levels during acute phase in the patients of cardiovascular disease remains unclear. We enrolled 257 consecutive cardiovascular patients admitted to the coronary care unit (CCU)...
December 9, 2016: Heart and Vessels
https://www.readbyqxmd.com/read/27941282/donor-cell-leukemia-with-bone-marrow-necrosis
#18
Shuntaro Ikegawa, Yuho Najima, Naoki Sano, Shin-Ichiro Horiguchi, Satoshi Kaito, Shuhei Kurosawa, Masahiro Sakaguchi, Kaito Harada, Yutaro Hino, Keita Yamamoto, Yasushi Senoo, Daisuke Watanabe, Kosuke Yoshioka, Kyoko Watakabe, Aiko Igarashi, Noriko Doki, Takeshi Kobayashi, Kazuhiko Kakihana, Hisashi Sakamaki, Tsunekazu Hishima, Kazuteru Ohashi
A 60-year-old man with myelodysplastic syndrome underwent allogeneic transplantation of female umbilical cord blood in 2010 and sustained a complete remission. He experienced severe pain in his left hip joint and was admitted to the orthopedic surgery division of our institution in February 2015. After admission, he was suspected to have hemophagocytic syndrome (HPS) and was thus transferred to the hematology division. Bone marrow aspiration revealed hyper-cellular marrow filled with abnormal collapsed cells, consistent with bone marrow necrosis (BMN)...
2016: [Rinshō Ketsueki] the Japanese Journal of Clinical Hematology
https://www.readbyqxmd.com/read/27940643/marine-heatwaves-and-optimal-temperatures-for-microbial-assemblage-activity
#19
Ian Joint, Dan A Smale
The response of microbial assemblages to instantaneous temperature change was measured in a seasonal study of the coastal waters of the western English Channel. On 18 occasions between November 1999 and December 2000, bacterial abundance was assessed and temperature responses determined from the incorporation of (3)H leucine, measured in a temperature gradient from 5-38°C. Q10 values varied, being close to 2 in spring and summer but were >3 in autumn. There was a seasonal pattern in the assemblage optimum temperature (Topt), which was out of phase with sea surface temperature...
December 8, 2016: FEMS Microbiology Ecology
https://www.readbyqxmd.com/read/27938385/comparison-of-the-effect-of-a-combination-of-eight-micronutrients-versus-a-standard-mono-preparation-on-sperm-parameters
#20
Markus Lipovac, Florian Bodner, Martin Imhof, Peter Chedraui
BACKGROUND: There are reports showing that l-carnitine alone or in combination with other micronutrients improve sperm parameters. However, comparative studies are still lacking. This study was carried out to compare the short term effects of a combination of eight micronutrients including l-carnitine vs. a mono-substance (l-carnitine alone) on sperm parameters. METHODS: This was a prospective, open-labelled, nonrandomized study that included male subjects (20 to 60 years) with at least 1 year of subfertility and at least one pathological semen analysis who received 3 months treatment with a mono-substance (500 mg l-carnitine/twice a day, n = 156) or a combined compound (440 mg l-carnitine + 250 mg l-arginine + 40 mg zinc + 120 mg vitamin E + 80 mg glutathione + 60 μg selenium + 15 mg coenzyme Q10 + 800 μg folic acid/once a day, n = 143) for the same time period...
December 9, 2016: Reproductive Biology and Endocrinology: RB&E
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