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https://www.readbyqxmd.com/read/28934353/correction-coenzyme-q10-plus-multivitamin-treatment-prevents-cisplatin-ototoxicity-in-rats
#1
Laura Astolfi, Edi Simoni, Filippo Valente, Sara Ghiselli, Stavros Hatzopoulos, Milvia Chicca, Alessandro Martini
[This corrects the article DOI: 10.1371/journal.pone.0162106.].
2017: PloS One
https://www.readbyqxmd.com/read/28933847/preparation-and-characterization-of-mucoadhesive-nanoparticles-for-enhancing-cellular-uptake-of-coenzyme-q10
#2
Ji-Soo Lee, Ji Woon Suh, Eun Suh Kim, Hyeon Gyu Lee
The mucoadhesive nanoparticles (NPs) for oral delivery of coenzyme Q10 (CoQ10) were prepared using natural mucoadhesive polysaccharides, chitosan (CS) and dextran sulfate sodium salt (DS) in order to improve the solubility, cellular uptake, thermo- and photo-stability of CoQ10. CoQ10-loaded NPs were prepared in the range of 340-450 nm with an entrapment efficiency of 60-98%. The mucoadhesiveness and cellular uptake of NPs were evaluated by measuring the amount of mucin adsorbed on NPs and CoQ10 absorbed in Caco-2 cells, respectively...
September 21, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28931064/dynamics-of-soil-organic-carbon-mineralization-in-tea-plantations-converted-from-farmland-at-western-sichuan-china
#3
Renhuan Zhu, Zicheng Zheng, Tingxuan Li, Xizhou Zhang, Shuqin He, Yongdong Wang, Tao Liu, Wei Li
Climate warming and land use change are some of the drivers affecting soil organic carbon (SOC) dynamics. The Grain for Green Project, local natural resources, and geographical conditions have resulted in farmland conversion into tea plantations in the hilly region of Western Sichuan. However, the effect of such land conversion on SOC mineralization remains unknown. In order to understand the temperature sensitivity of SOC decomposition in tea plantations converted from farmland, this study considered the different years (i...
2017: PloS One
https://www.readbyqxmd.com/read/28921725/coenzyme-q10-prevents-the-interleukin-1-beta-induced-inflammatory-response-via-inhibition-of-mapk-signaling-pathways-in-rat-articular-chondrocytes
#4
Xing Li, Yuanqing Guo, Shuai Huang, Minhui He, Qiaoli Liu, Weizhi Chen, Minghao Liu, Dongliang Xu, Peiheng He
Preclinical Research Osteoarthritis (OA) is a widely prevalent degenerative joint disease that severely impairs the health of the elderly population resulting in a heavy economic burden worldwide. Coenzyme Q10 (CoQ10) has shown anti-inflammatory effects in some diseases. The present study aimed to investigate if CoQ10 would suppress catabolic responses of interleukin (IL)-1β-induced chondrocytes. Rat chondrocytes were cultured and pretreated with CoQ10, and then stimulated with or without IL-1β (10 ng/ml)...
September 17, 2017: Drug Development Research
https://www.readbyqxmd.com/read/28915379/study-on-the-oxygen-reduction-reaction-catalyzed-by-a-cold-tolerant-marine-strain-phylogenetically-related-to-erythrobacter-citreus
#5
Lianqiang Li, Fei Ding, Lin Sang, Jiaquan Liu, Duolu Mao, Xingjiang Liu, Qiang Xu
As the development of marine economy, the submarine battery with the seawater electrolyte has obtained more and more attentions. Owing to the conventional electrochemical catalysts of the cathodes in seawater battery are expensive, it is to seek the new biological catalysts to improve the electrochemical performance of the cathode and reduce the cost of seawater battery. A novel marine bacterial strain (Strain SQ-32) phylogenetically related to the Erythrobactercitreus strain has been isolated from the sea-bed sludge in the Yellow Sea of China successfully...
September 8, 2017: Bioelectrochemistry
https://www.readbyqxmd.com/read/28910698/temperature-inocula-and-substrate-contrasting-electroactive-consortia-diversity-and-performance-in-microbial-fuel-cells
#6
E S Heidrich, J Dolfing, M J Wade, W T Sloan, C Quince, T P Curtis
The factors that affect microbial community assembly and its effects on the performance of bioelectrochemical systems are poorly understood. Sixteen microbial fuel cell (MFC) reactors were set up to test the importance of inoculum, temperature and substrate: Arctic soil versus wastewater as inoculum; warm (26.5°C) versus cold (7.5°C) temperature; and acetate versus wastewater as substrate. Substrate was the dominant factor in determining performance and diversity: unexpectedly the simple electrogenic substrate delivered a higher diversity than a complex wastewater...
July 22, 2017: Bioelectrochemistry
https://www.readbyqxmd.com/read/28902670/neuroprotective-effects-of-coenzyme-q10-on-paraquat-induced-parkinson-s-disease-in-experimental-animals
#7
Hanan Naeim Attia, Yousreya Aly Maklad
Parkinson's disease (PD) affects ∼1-2% of the elderly population. Development of a neuroprotective therapy that may be initiated early in the course of the disease to retard/prevent disease progression is highly desirable. This study aimed to investigate prophylactic treatment with coenzyme Q10 (CoQ10) before paraquat (PQ) exposure, a herbicide known to increase the risk for PD, to attain neuroprotection. In addition, therapeutic intervention with CoQ10 in mice already exposed to PQ (24 h) might halt ongoing neurodegeneration and behavioural deterioration...
September 11, 2017: Behavioural Pharmacology
https://www.readbyqxmd.com/read/28901410/depletion-of-ubia-prenyltransferase-domain-containing-1-expression-promotes-angiotensin-ii%C3%A2-induced-hypertrophic-response-in-ac16-human-myocardial-cells-via-modulating-the-expression-levels-of-coenzyme-q10-and-endothelial-nitric-oxide-synthase
#8
Bingju Yan, Yingxian Sun, Jun Wang
UbiA prenyltransferase domain containing 1 (UBIAD1) is closely associated with cardiovascular diseases. However, at the cellular level, little is known about how UBIAD1 is expressed and functions in cardiomyocyte hypertrophy. The aim of the present study was to investigate the expression and role of UBIAD1 in angiotensin II (Ang II)‑induced hypertrophy in AC16 cardiomyoblast cells. The loss‑of‑function approach was used to knock down UBIAD1 in vehicle‑ and Ang II‑stimulated AC16 cells. The levels of atrial natriuretic factor (ANF) and caspase-3 were measured and compared between vehicle‑ and Ang II‑treated AC16 cells pretreated with control siRNA or siRNA against UBIAD1...
August 31, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28900834/coq10-increases-mitochondrial-mass-and-polarization-atp-and-oct4-potency-levels-and-bovine-oocyte-mii-during-ivm-while-decreasing-ampk-activity-and-oocyte-death
#9
M K Abdulhasan, Q Li, J Dai, H M Abu-Soud, E E Puscheck, D A Rappolee
PURPOSE: We tested whether mitochondrial electron transport chain electron carrier coenzyme Q10 (CoQ10) increases ATP during bovine IVM and increases %M2 oocytes, mitochondrial polarization/mass, and Oct4, and decreases pAMPK and oocyte death. METHODS: Bovine oocytes were aspirated from ovaries and cultured in IVM media for 24 h with 0, 20, 40, or 60 μM CoQ10. Oocytes were assayed for ATP by luciferase-based luminescence. Oocyte micrographs were quantitated for Oct4, pAMPK (i...
September 12, 2017: Journal of Assisted Reproduction and Genetics
https://www.readbyqxmd.com/read/28895754/coenzyme-q10-and-retinaldehyde-co-loaded-nanostructured-lipid-carriers-for-efficacy-evaluation-in-wrinkles
#10
Kritika Nayak, Sameer S Katiyar, Varun Kushwah, Sanyog Jain
The present study depicts coenzyme Q10 (CoQ10) and retinaldehyde (RAL) co-loaded Nanostructured Lipid Carriers (NLCs); having activity on different targets of photoageing, which can overcome deficits of conventional topical dosage forms. The developed NLCs were characterized for particle size, polydispersity index, and % Entrapment efficiency, followed by their incorporation into Carbopol® 934P-NF gel. In vitro cellular uptake and cytotoxicity assay was performed to evaluate NLCs and in vivo study on UV induced wrinkle model to determine efficacy of NLCs...
September 12, 2017: Journal of Drug Targeting
https://www.readbyqxmd.com/read/28868271/prenatal-diagnosis-of-mosaic-tetrasomy-18p-in-a-case-without-sonographic-abnormalities
#11
Javad Karimzad Hagh, Thomas Liehr, Hamid Ghaedi, Mir Majid Mossalaeie, Shohreh Alimohammadi, Faegheh Inanloo Hajiloo, Zahra Moeini, Sadaf Sarabi, Davood Zare-Abdollahi
Small supernumerary marker chromosomes (sSMC) are still a major problem in clinical cytogenetics as they cannot be identified or characterized unambiguously by conventional cytogenetics alone. On the other hand, and perhaps more importantly in prenatal settings, there is a challenging situation for counseling how to predict the risk for an abnormal phenotype, especially in cases with a de novo sSMC. Here we report on the prenatal diagnosis of a mosaic tetrasomy 18p due to presence of an sSMC in a fetus without abnormal sonographic signs...
2017: International Journal of Molecular and Cellular Medicine
https://www.readbyqxmd.com/read/28866997/kushneria-konosiri-sp-nov-isolated-from-the-korean-salt-fermented-seafood-daemi-jeot
#12
Ji-Hyun Yun, Seong-Kyu Park, June-Young Lee, Mi-Ja Jung, Jin-Woo Bae
A halophilic bacterial strain, X49T, was isolated from the Korean traditional salt-fermented seafood Daemi-jeot. X49T was an obligately aerobic, Gram-stain-negative, motile, oval or rod-shaped (0.5-1.0×1.2-3.2 µm) bacterium. After 2 days of growth, colonies on Marine agar medium were orange and circular with entire margins. X49T growth was detected at 10-37 °C and pH 4.5-8.5 in the presence of 0-26 % (w/v) NaCl. The 16S rRNA gene sequence of strain X49T was most similar to that of the type strain of Kushneria marisflavi SW32T and shared a sequence similarity of 94...
September 2017: International Journal of Systematic and Evolutionary Microbiology
https://www.readbyqxmd.com/read/28864378/potential-cardiovascular-and-renal-protective-effects-of-vitamin-d-and-coenzyme-q10-in-l-name-induced-hypertensive-rats
#13
Hanan A Shamardl, Sahar M El-Ashmony, Hala F Kamel, Sameer H Fatani
BACKGROUND: Hypertension is one of the primary modifiable risk factors for cardiovascular disease. Adequate vitamin D (vit D) levels have been shown to reduce vascular smooth muscle contraction and to increase arterial compliance, which may be beneficial in hypertension. Further, coenzyme Q10 (COQ10) through its action to lower oxidative stress has been reported to have beneficial effects on hypertension and heart failure. This study examined the possible cardiac and renal protective effects of vit D and COQ10 both separately and in combination with an angiotensin II receptor blocker, valsartan (vals) in l-NAME hypertensive rats...
August 2017: American Journal of the Medical Sciences
https://www.readbyqxmd.com/read/28862306/novel-hplc-uv-method-for-simultaneous-determination-of-fat-soluble-vitamins-and-coenzyme-q10-in-medicines-and-supplements
#14
Žane Temova-Rakuša, Eva Srečnik, Robert Roškar
A precise, accurate and rapid HPLC-UV method for simultaneous determination of fat-soluble vitamins (vitamin D3, E-acetate, K1, β-carotene, A-palmitate) and coenzyme Q10 was developed and validated according to ICH guidelines. Optimal chromatographic separation of the analytes in minimal analysis time (8 min) was achieved on a Luna C18 150 × 4.6 mm column using a mixture of acetonitrile, tetrahydrofuran and water (50:45:5, v/v/v). The described reversed phase HPLC method is the first published for quantification of these five fat-soluble vitamins and coenzyme Q10 within a single chromatographic run...
September 2017: Acta Chimica Slovenica
https://www.readbyqxmd.com/read/28854909/a-combination-of-coenzyme-q10-feverfew-and-magnesium-for-migraine-prophylaxis-a-prospective-observational-study
#15
Angèle Guilbot, Marie Bangratz, Samira Ait Abdellah, Christian Lucas
BACKGROUND: Feverfew (Tanacetum parthenium L.), magnesium and coenzyme Q10 are frequently used for migraine prophylaxis. Supplementation with a fixed combination of these three agents (Antemig®, PiLeJe) was investigated in an observational study. METHODS: Adult patients suffering from migraine according to the criteria of the International Headache Society were enrolled by general practitioners (≥2 migraine attacks during previous month; exclusion of chronic migraine and medication overuse) and after a one-month baseline phase, supplemented with one tablet of 100 mg feverfew, 100 mg coenzyme Q10 and 112...
August 30, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/28844183/attenuation-of-oxidative-damage-by-coenzyme-q10-loaded-nanoemulsion-via-oral-route-for-the-management-of-parkinson-s-disease
#16
Sanjula Baboota, Bijay Kumar Gupta, Shobhit Kumar, Harleen Kaur, Javed Ali
Coenzyme Q10 (CoQ10) is a well known antioxidant molecule which is used in the treatment of neurodegenerative disorders but due to poor solubility it suffers with the drawback of low oral bioavailability. The aim of present study was to prepare and characterize CoQ10 loaded nanoemulsion to improve the oral bioavailability. Prepared formulation was studied for droplet size, polydispersity index (PDI), percentage transmittance, refractive index, viscosity, zeta potential, surface morphology by transmission electron microscopy (TEM) and in vitro release study...
August 26, 2017: Rejuvenation Research
https://www.readbyqxmd.com/read/28843040/prospects-for-bio-industrial-application-of-an-extremely-alkaline-mannanase-from-bacillus-subtilis-subsp-inaquosorum-csb31
#17
Sudip Regmi, Hah Y Yoo, Yun H Choi, Yoon S Choi, Jin C Yoo, Seung W Kim
Mannan-degrading enzymes have been growing interest in bio-industrial applications, such as the pulp and paper, food, and pharmaceutical industries. In this study, an extremely alkaline mannanase (MnB31) is produced by Bacillus subtilis subsp. inaquosorum CSB31. MnB31 is purified to 17.92-fold with a 21.51% yield and specific activity of 1,796.13 U mg(-1) by anion-exchange and gel filtration column chromatography. The biochemical characterization of MnB31 is performed, and the results are as follows: molecular weight of ≈47 kDa with an optimum temperature of 60 °C and pH of 12...
August 26, 2017: Biotechnology Journal
https://www.readbyqxmd.com/read/28840796/monaibacterium-marinum-gen-nov-sp-nov-a-new-member-of-the-alphaproteobacteria-isolated-from-seawater-of-menai-straits-wales-uk
#18
Tatyana N Chernikova, James Dallimore, Heinrich Lünsdorf, Hermann J Heipieper, Peter N Golyshin
The novel Gram-negative, aerobic, non-motile, non-spore-forming, short-rod bacterium, strain C7T, was isolated from a seawater sample from Menai Straits (Wales, UK) and characterized. Phylogenetic analysis of 16S rRNA gene sequences showed that this strain represented a distinct lineage within the Roseobacterclade of family Rhodobacteracea within Alphaproteobacteria. The members of the genera Pontivivens (Pontivivensinsulae GYSW-23T), Celeribacter (Celeribactermanganoxidans DY2-5T), Donghicola (Donghicola eburneus SW-277T), Roseovarius (Roseovariushalotolerans HJ50T and Roseovariuspacificus 81-2T), Cribrihabitans (Cribrihabitansmarinus CZ-AM5T) and Aestuariihabitans (Aestuariihabitansbeolgyonensis BB-MW15T) were the closest relatives with 16S rRNA gene sequence identities between 93...
September 2017: International Journal of Systematic and Evolutionary Microbiology
https://www.readbyqxmd.com/read/28825533/analysis-of-closely-related-antioxidant-nutraceuticals-using-the-green-analytical-methodology-of-ann-and-smart-spectrophotometric-methods
#19
Mohamed A Korany, Azza A Gazy, Essam F Khamis, Marwa A A Ragab, Miranda F Kamal
Two new, simple, and specific green analytical methods are proposed: zero-crossing first-derivative and chemometric-based spectrophotometric artificial neural network (ANN). The proposed methods were used for the simultaneous estimation of two closely related antioxidant nutraceuticals, coenzyme Q10 (Q10) and vitamin E, in their mixtures and pharmaceutical preparations. The first method is based on the handling of spectrophotometric data with the first-derivative technique, in which both nutraceuticals were determined in ethanol, each at the zero crossing of the other...
January 1, 2017: Journal of AOAC International
https://www.readbyqxmd.com/read/28816577/coenzyme-q10-inhibits-th17-and-stat3-signaling-pathways-to-ameliorate-colitis-in-mice
#20
Seon-Yeong Lee, Seung Hoon Lee, Eun-Ji Yang, Jae-Kyung Kim, Eun-Kyung Kim, KyungAh Jung, Hongsoon Jung, Kyungjin Lee, Han Hee Lee, Bo-In Lee, Sung-Hwan Park, Dong Yun Shin, Mi-La Cho
Coenzyme Q10 (CoQ10) is a powerful antioxidant substance synthesized in the body. The current study aimed to determine whether CoQ10 suppresses inflammation and inhibits p-STAT3 expression in an experimental colitis mouse model. The mice were orally fed with CoQ10 once a day for 13 days. Histological analysis of the colons was performed by immunohistochemistry. Expression of IL-17, FOXP3, p53, AMPK, and mTOR and activation of p-STAT3 and p-STAT5 in lymph node and spleen tissues were detected by confocal microscopy of stained tissue sections...
September 2017: Journal of Medicinal Food
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