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https://www.readbyqxmd.com/read/28736527/human-coq9-rescues-a-coq9-yeast-mutant-by-enhancing-coenzyme-q-biosynthesis-from-4-hydroxybenzoic-acid-and-stabilizing-the-coq-synthome
#1
Cuiwen H He, Dylan S Black, Christopher M Allan, Brigitte Meunier, Shamima Rahman, Catherine F Clarke
Coq9 is required for the stability of a mitochondrial multi-subunit complex, termed the CoQ-synthome, and the deamination step of Q intermediates that derive from para-aminobenzoic acid (pABA) in yeast. In human, mutations in the COQ9 gene cause neonatal-onset primary Q10 deficiency. In this study, we determined whether expression of human COQ9 could complement yeast coq9 point or null mutants. We found that expression of human COQ9 rescues the growth of the temperature-sensitive yeast mutant, coq9-ts19, on a non-fermentable carbon source and increases the content of Q6, by enhancing Q biosynthesis from 4-hydroxybenzoic acid (4HB)...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/28722258/in-vitro-evaluation-of-chitosan-coated-liposome-containing-both-coenzyme-q10-and-alpha-lipoic-acid-cytotoxicity-antioxidant-activity-and-antimicrobial-activity
#2
Guodong Zhao, Caibiao Hu, Ying Xue
BACKGROUND: Chitosan-coated liposome containing both coenzyme Q10 and alpha-lipoic acid (CCAL) was a novel multifunctional nano delivery system exhibited long-term stability at room temperature and high encapsulation efficiency. Which containing two kinds of antioxidants (coenzyme Q10 and alpha-lipoic acid) and two antibacterial agents (chitosan and alpha-lipoic acid). However, the further biocompatibility, such as cytotoxicity and antioxidant activity, and antimicrobial activity of CCAL, has not been systematically evaluated...
July 19, 2017: Journal of Cosmetic Dermatology
https://www.readbyqxmd.com/read/28720763/high-frequency-of-runx1-mutation-in-myelodysplastic-syndrome-patients-with-whole-arm-translocation-of-der-1-7-q10-p10
#3
T Zhang, Y Xu, J Pan, H Li, Q Wang, L Wen, D Wu, A Sun, S Chen
Leukemia accepted article preview online, 19 July 2017. doi:10.1038/leu.2017.228.
July 19, 2017: Leukemia: Official Journal of the Leukemia Society of America, Leukemia Research Fund, U.K
https://www.readbyqxmd.com/read/28717270/antioxidant-therapy-in-idiopathic-oligoasthenoteratozoospermia
#4
REVIEW
Ahmad Majzoub, Ashok Agarwal
INTRODUCTION: Idiopathic oligoasthenoteratozoospermia (iOAT) is commonly encountered during the evaluation of men with infertility. Antioxidants have been utilized empirically in the treatment of iOAT based on their ability to reverse oxidative stress (OS)-induced sperm dysfunction often encountered in this patient population. METHODS: A literature search was performed using MEDLINE/PubMed, focusing on publications of antioxidant therapies for iOAT. The main objective of our review article was to report the rationale and available evidence supporting the use of antioxidants...
July 2017: Indian Journal of Urology: IJU: Journal of the Urological Society of India
https://www.readbyqxmd.com/read/28699865/phaeobacter-porticola-sp-nov-an-antibiotic-producing-bacterium-isolated-from-a-sea-harbour
#5
Sven Breider, Heike M Freese, Cathrin Spröer, Meinhard Simon, Jörg Overmann, Thorsten Brinkhoff
Three heterotrophic, aerobic, brown-pigmented strains, designated P97T, P100 and P104, were isolated from a harbour in the southern North Sea. Phylogenetic analysis of 16S rRNA gene sequences revealed that the isolates are affiliated to the genus Phaeobacter. In silico DNA-DNA hybridization of the genome of strain P97T against those of existing type species indicated that P97T represents a novel species within the genus Phaeobacter, with Phaeobacter inhibens T5T as the closest described organism (29.6 % DNA-DNA relatedness) followed by P...
July 12, 2017: International Journal of Systematic and Evolutionary Microbiology
https://www.readbyqxmd.com/read/28698101/coenzyme-q10-ameliorates-cerebral-ischemia-reperfusion-injury-in-hyperglycemic-rats
#6
Cui-Jie Lu, Yong-Zhen Guo, Yang Zhang, Lan Yang, Yue Chang, Jing-Wen Zhang, Li Jing, Jian-Zhong Zhang
The purpose of this study is to investigate the effect of coenzyme Q10 (CoQ10) on focal cerebral ischemia/reperfusion (I/R) injury in hyperglycemic rats and the possible involved mechanisms. In this study, we established the transient middle cerebral artery occlusion (MCAO) for 30min in the rats with diabetic hyperglycemia. The neurological deficit score, 2,3,5-triphenyltetrazolium chloride (TTC) staining and pathohistology are applied to detect the extent of the damage. The expression of Fis1, Mfn2 and Lc3 in the brain is investigated by immunohistochemical and Western blotting techniques...
June 15, 2017: Pathology, Research and Practice
https://www.readbyqxmd.com/read/28697789/improvement-in-asymmetric-dimethylarginine-and-oxidative-stress-in-patients-with-limb-salvage-after-autologous-mononuclear-stem-cell-application-for-critical-limb-ischemia
#7
Juraj Madaric, Martina Valachovicova, Ludovit Paulis, Jana Pribojova, Renata Mateova, Katarina Sebekova, Luba Postulkova, Terezia Madaricova, Maria Bucova, Martin Mistrik, Ivan Vulev
BACKGROUND: Asymmetric dimethylarginine (ADMA), an endogenous inhibitor of nitric oxide synthase, acts as an inhibitor of angiogenesis and is associated with an increased risk of cardiovascular mortality. Administration of stem cells may affect endogenous mechanisms that regulate ADMA production and metabolism. The aim of the present study was to analyze ADMA concentration and changes in oxidative stress in patients with advanced critical limb ischemia (CLI) after bone marrow-derived mononuclear cell (BM-MNC) therapy...
July 12, 2017: Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/28692411/evaluation-of-the-health-benefits-of-a-multivitamin-multimineral-herbal-essential-oil-infused-supplement-a-pilot-trial
#8
Xuesheng Han, Dennis L Eggett, Tory L Parker
This study was designed to quantitatively evaluate the health benefits of a multivitamin, multimineral, herbal, essential oil-infused supplement using serum biomarkers. We also qualitatively evaluated the health effects of this supplement using a survey. Sixteen participants were recruited to take the supplement as directed for two months. The levels of the following serum components were measured in the participants: total cholesterol, high-density lipoprotein (HDL) cholesterol, low-density lipoprotein (LDL) cholesterol, triglycerides, lipoprotein(a), LDL/HDL cholesterol ratio, total/HDL cholesterol ratio, ferritin, fibrinogen, C-reactive protein, insulin, testosterone, sex hormone binding globulin, free androgen index, red blood cell magnesium, homocysteine, coenzyme Q10, lipid peroxides, alpha-tocopherol, gamma-tocopherol, cardiovascular index, eicosapentaenoic acid (EPA), arachidonic acid (AA), and the AA/EPA ratio...
July 10, 2017: Journal of Dietary Supplements
https://www.readbyqxmd.com/read/28690551/impact-of-chemical-analogs-of-4-hydroxybenzoic-acid-on-coenzyme-q-biosynthesis-from-inhibition-to-bypass-of-coenzyme-q-deficiency
#9
REVIEW
Fabien Pierrel
Coenzyme Q is a lipid that participates to important physiological functions. Coenzyme Q is synthesized in multiple steps from the precursor 4-hydroxybenzoic acid. Mutations in enzymes that participate to coenzyme Q biosynthesis result in primary coenzyme Q deficiency, a type of mitochondrial disease. Coenzyme Q10 supplementation of patients is the classical treatment but it shows limited efficacy in some cases. The molecular understanding of the coenzyme Q biosynthetic pathway allowed the design of experiments to bypass deficient biosynthetic steps with analogs of 4-hydroxybenzoic acid...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/28689120/temperature-sensitivity-of-total-soil-respiration-and-its-heterotrophic-and-autotrophic-components-in-six-vegetation-types-of-subtropical-china
#10
Shiqin Yu, Yuanqi Chen, Jie Zhao, Shenglei Fu, Zhian Li, Hanping Xia, Lixia Zhou
The temperature sensitivity of soil respiration (Q10) is a key parameter for estimating the feedback of soil respiration to global warming. The Q10 of total soil respiration (Rt) has been reported to have high variability at both local and global scales, and vegetation type is one of the most important drivers. However, little is known about how vegetation types affect the Q10 of soil heterotrophic (Rh) and autotrophic (Ra) respirations, despite their contrasting roles in soil carbon sequestration and ecosystem carbon cycles...
July 6, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28684614/ubiquinol-effects-on-antiphospholipid-syndrome-prothrombotic-profile-a-randomized-placebo-controlled-trial
#11
Carlos Pérez-Sánchez, María Ángeles Aguirre, Patricia Ruiz-Limón, María Carmen Abalos-Aguilera, Yolanda Jiménez-Gómez, Iván Arias-de la Rosa, Antonio Rodriguez-Ariza, Lucía Fernández-Del Río, José Antonio Gonzalez-Reyes, Pedro Segui, Eduardo Collantes-Estévez, Nuria Barbarroja, Francisco Velasco, Savino Sciascia, Irene Cecchi, María José Cuadrado, José Manuel Villalba, Chary López-Pedrera
OBJECTIVE: Antiphospholipid syndrome (APS) leukocytes exhibit an oxidative perturbation, directly linked to alterations in mitochondrial dynamics and metabolism. This disturbance is related to the patients' prothrombotic status and can be prevented by in vitro treatment with coenzyme Q10. Our aim was to investigate short-term effects of in vivo ubiquinol (reduced coenzyme Q10[Qred]) supplementation on markers related to inflammation and thrombosis in APS through a prospective, randomized, crossover, placebo-controlled trial...
July 6, 2017: Arteriosclerosis, Thrombosis, and Vascular Biology
https://www.readbyqxmd.com/read/28683779/ambient-temperature-and-genotype-differentially-affect-developmental-and-phenotypic-plasticity-in-arabidopsis-thaliana
#12
Carla Ibañez, Yvonne Poeschl, Tom Peterson, Julia Bellstädt, Kathrin Denk, Andreas Gogol-Döring, Marcel Quint, Carolin Delker
BACKGROUND: Global increase in ambient temperatures constitute a significant challenge to wild and cultivated plant species. Forward genetic analyses of individual temperature-responsive traits have resulted in the identification of several signaling and response components. However, a comprehensive knowledge about temperature sensitivity of different developmental stages and the contribution of natural variation is still scarce and fragmented at best. RESULTS: Here, we systematically analyze thermomorphogenesis throughout a complete life cycle in ten natural Arabidopsis thaliana accessions grown under long day conditions in four different temperatures ranging from 16 to 28 °C...
July 6, 2017: BMC Plant Biology
https://www.readbyqxmd.com/read/28671528/bombella-apis-sp-nov-an-acetic-acid-bacterium-isolated-from-the-midgut-of-a-honey-bee
#13
Ji-Hyun Yun, June-Young Lee, Dong-Wook Hyun, Mi-Ja Jung, Jin-Woo Bae
As part of a study to investigate the microbial diversity in the intestine of Apis mellifera, we isolated strain MRM1T from the midgut. MRM1T was a Gram-stain-negative, strictly aerobic, non-motile, non-spore forming and rod-shaped bacteria. Creamy beige-coloured colonies were circular with entire margins in Lactobacilli MRS agar. The strain grew at 25-37 °C (optimum, 30-37 °C) and at a pH range of 4.0 to 9.0 (optimum pH, 7.0-8.5). The strain tolerated 0-1 % (w/v) NaCl (optimal growth occurred in the absence of NaCl)...
July 3, 2017: International Journal of Systematic and Evolutionary Microbiology
https://www.readbyqxmd.com/read/28671136/analysis-of-participant-withdrawal-in-huntington-disease-clinical-trials
#14
Haruhiko Banno, Kelly L Andrzejewski, Michael P McDermott, Alyssa Murphy, Madhurima Majumder, Elisabeth A de Blieck, Peggy Auinger, Merit E Cudkowicz, Nazem Atassi
BACKGROUND: Excellent retention in Huntington disease (HD) clinical trials is essential for testing new therapies. The stage of disease, cognitive status, and availability of a care partner may influence retention in HD clinical trials. OBJECTIVE: We sought to analyze reasons for early withdrawal in three HD clinical trials, and evaluated if either baseline characteristics or follow-up assessments were associated with time to withdrawal. METHODS: Analyses of participant withdrawal were performed for three randomized, double-blind, placebo-controlled trials including the CARE-HD (coenzyme Q10 and remacemide in HD, n = 347), DOMINO (pilot study of minocycline in HD, n = 114), and 2CARE (coenzyme Q10 in HD, n = 609) trials...
2017: Journal of Huntington's Disease
https://www.readbyqxmd.com/read/28670881/ameliorative-effect-of-coenzyme-q10-and-or-candesartan-on-carboplatin-induced-nephrotoxicity-roles-of-apoptosis-transforming-growth-factor-%C3%AE-1-nuclear-factor-kappa-b-and-the-nrf2-ho-1-pathway
#15
Ahmed M Kabel, Abeer A Elkhoely
Background: Carboplatin is a drug that is used for treatment of many types of cancer. However, it may produce serious nephrotoxicity. Candesartan is angiotensin II receptor antagonist employed mainly for control of hypertension. Coenzyme Q10 (CoQ10) is a fat-soluble substance which was proven to have potent antioxidant and anti-inflammatory properties. Aim: Our aim was to study the effects of candesartan and/or CoQ10 on carboplatin-induced nephrotoxicity in mice. Methods: Sixty mice were divided into 6 equal groups: Control untreated; carboplatin; carboplatin + candesartan; carboplatin + CoQ10; carboplatin + carboxymethyl cellulose; and carboplatin + candesartan + CoQ10 group...
June 25, 2017: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/28661441/loss-of-bone-mineral-density-associated-with-age-in-male-rats-fed-on-sunflower-oil-is-avoided-by-virgin-olive-oil-intake-or-coenzyme-q-supplementation
#16
Alfonso Varela-López, Julio J Ochoa, José M Llamas-Elvira, Magdalena López-Frías, Elena Planells, Lorenza Speranza, Maurizio Battino, José L Quiles
The role of dietary fat unsaturation and the supplementation of coenzyme Q have been evaluated in relation to bone health. Male Wistar rats were maintained for 6 or 24 months on two diets varying in the fat source, namely virgin olive oil, rich in monounsaturated fatty acids, or sunflower oil, rich in n-6 polyunsaturated fatty acids. Both dietary fats were supplemented or not with coenzyme Q10 (CoQ10). Bone mineral density (BMD) was evaluated in the femur. Serum levels of osteocalcin, osteopontin, receptor activator of nuclear factor κB ligand (RANKL), osteoprotegerin (OPG), adrenocorticotropin (ACTH) and parathyroid hormone (PTH), as well as urinary F₂-isoprostanes were measured...
June 29, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28643190/mitochondrial-biogenesis-and-neural-differentiation-of-human-ipsc-is-modulated-by-idebenone-in-a-developmental-stage-dependent-manner
#17
J Augustyniak, J Lenart, M Zychowicz, P P Stepien, L Buzanska
Idebenone, the synthetic analog of coenzyme Q10 can improve electron transport in mitochondria. Therefore, it is used in the treatment of Alzheimer's disease and other cognitive impairments. However, the mechanism of its action on neurodevelopment is still to be elucidated. Here we demonstrate that the cellular response of human induced pluripotent stem cells (hiPSC) to idebenone depends on the stage of neural differentiation. When: neural stem cells (NSC), early neural progenitors (eNP) and advanced neural progenitors (NP) have been studied a significant stimulation of mitochondrial biogenesis was observed only at the eNP stage of development...
June 22, 2017: Biogerontology
https://www.readbyqxmd.com/read/28642201/combination-of-coenzyme-q10-loaded-liposomes-with-ultrasound-targeted-microbubbles-destruction-utmd-for-early-theranostics-of-diabetic-nephropathy
#18
Ting Yue, He-Lin Xu, Pian-Pian Chen, Lei Zheng, Qun Huang, Wen-Shuang Sheng, Yuan-Di Zhuang, Li-Zhuo Jiao, Ting-Ting Chi, De-Li ZhuGe, Jin-Jin Liu, Ying-Zheng Zhao, Li Lan
Diabetic nephropathy (DN) is one of the most common and lethal microvascular complications of diabetes. This study aimed to explore whether coenzymeQ10 (CoQ10) as an antioxidant combined with ultrasound-targeted microbubble destruction (UTMD) could reverse the progress of early diabetic nephropathy (DN). CoQ10 has great potential to treat early DN. However, the clinical application of CoQ10 has been limited because of its low aqueous solubility and non-specific distribution. Therefore, CoQ10-loaded liposomes (CoQ10-lip) were prepared and combined with ultrasound microbubbles for the early theranostics of DN...
June 19, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28637167/effects-of-dissolved-oxygen-concentration-on-photosynthetic-bacteria-wastewater-treatment-pollutants-removal-cell-growth-and-pigments-production
#19
Fan Meng, Anqi Yang, Guangming Zhang, Hangyao Wang
Dissolved oxygen (DO) is an important parameter in photosynthetic bacteria (PSB) wastewater treatment. This study set different DO levels and detected the pollutants removal, PSB growth and pigments production. Results showed that DO significantly influenced the performances of PSB wastewater treatment process. The highest COD (93%) and NH3-N removal (83%) was achieved under DO of 4-8mg/L, but DO of 2-4mg/L was recommended considering the aeration cost. PSB biomass reached 1645mg/L under DO of 4-8mg/L with satisfying co-enzyme Q10 content...
October 2017: Bioresource Technology
https://www.readbyqxmd.com/read/28623382/carbon-and-hydrogen-isotope-fractionation-during-aerobic-biodegradation-of-quinoline-and-3-methylquinoline
#20
Mingchao Cui, Wenbing Zhang, Jun Fang, Qianqiong Liang, Dongxuan Liu
Compound-specific isotope analysis has been used extensively to investigate the biodegradation of various organic pollutants. To date, little isotope fractionation information is available for the biodegradation of quinolinic compounds. In this study, we report on the carbon and hydrogen isotope fractionation during quinoline and 3-methylquinoline aerobic microbial degradation by a Comamonas sp. strain Q10. Degradation of quinoline and 3-methylquinoline was accompanied by isotope fractionation. Large hydrogen and small carbon isotope fractionation was observed for quinoline while minor carbon and hydrogen isotope fractionation effects occurred for 3-methylquinoline...
June 16, 2017: Applied Microbiology and Biotechnology
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