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https://www.readbyqxmd.com/read/29348109/review-beyond-conventional-therapies-complementary-and-alternative-medicine-in-the-management-of-hypertension-an-evidence-based-review
#1
Ang Peng Wong, Yaman Walid Kassab, Abdul Latiff Mohamed, Amelah Mohammed Abdul Qader
Hypertension is one of the major causes of morbidity and mortality. Worldwide, Hypertension is estimated to cause 7.5 million deaths, about 12.8% of the total of all deaths. This accounts for 57 million disability adjusted life years (DALYS) or 3.7% of total DALYS. This led WHO to set a target of 25% reduction in prevalence by 2025. To reach that, WHO has adopted non-conventional methods for the management of hypertension? Despite worldwide popularity of such non-conventional therapies, only small volume of evidence exists that supports its effectiveness...
January 2018: Pakistan Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29346060/a-combination-with-probiotic-complex-zinc-and-coenzyme-q10-attenuates-autoimmune-arthritis-by-regulation-of-th17-treg-balance
#2
Seon-Young Lee, Seung Hoon Lee, JooYeon Jhun, Hyeon-Beom Seo, Kyung Ah Jung, Chul Woo Yang, Sung-Hwan Park, Mi-La Cho
Probiotic complex, zinc, and coenzyme Q10 (CoQ10) are recognized dietary supplements with an anti-inflammatory role. Although these supplementations are individually known to benefit rheumatoid arthritis (RA), there is no evidence suggesting any synergic effect. The primary goal of this study is to determine whether probiotic complex, zinc, and CoQ10 attenuate the development of collagen-induced arthritis (CIA). The combination of probiotic complex, zinc, and CoQ10 reduced CIA severity by downregulating the levels of IgG, IgG1, and IgG2a in serum...
January 2018: Journal of Medicinal Food
https://www.readbyqxmd.com/read/29345091/the-responses-of-microbial-temperature-relationships-to-seasonal-change-and-winter-warming-in-a-temperate-grassland-soil
#3
Johanna Birgander, Pål Axel Olsson, Johannes Rousk
Microorganisms dominate the decomposition of organic matter and their activities are strongly influenced by temperature. As the carbon (C) flux from soil to the atmosphere due to microbial activity is substantial, understanding temperature relationships of microbial processes is critical. It has been shown that microbial temperature relationships in soil correlate with the climate, and microorganisms in field experiments become more warm-tolerant in response to chronic warming. It is also known that microbial temperature relationships reflect the seasons in aquatic ecosystems, but to date this has not been investigated in soil...
January 18, 2018: Global Change Biology
https://www.readbyqxmd.com/read/29330704/the-effects-of-coenzyme-q10-supplementation-on-blood-pressures-among-patients-with-metabolic-diseases-a-systematic-review-and-meta-analysis-of-randomized-controlled-trials
#4
Reza Tabrizi, Maryam Akbari, Nasrin Sharifi, Kamran B Lankarani, Mahmood Moosazadeh, Fariba Kolahdooz, Mohsen Taghizadeh, Zatollah Asemi
INTRODUCTION: Although several trials have assessed the effect of coenzyme Q10 (CoQ10) supplementation on blood pressures among patients with metabolic diseases, findings are controversial. AIM: This review of randomized controlled trials (RCTs) was performed to summarize the evidence on the effects of CoQ10 supplementation on blood pressures among patients with metabolic diseases. METHODS: Randomized-controlled trials (RCTs) published in PubMed, EMBASE, Web of Science and Cochrane Library databases up to 10 August 2017 were searched...
January 12, 2018: High Blood Pressure & Cardiovascular Prevention: the Official Journal of the Italian Society of Hypertension
https://www.readbyqxmd.com/read/29329705/low-cost-and-disposable-sensors-for-the-simultaneous-determination-of-coenzyme-q10-and-%C3%AE-lipoic-acid-using-manganese-iv-oxide-modified-screen-printed-graphene-electrodes
#5
Kanokwan Charoenkitamorn, Sudkate Chaiyo, Orawon Chailapakul, Weena Siangproh
In this work, for the first time, manganese (IV) oxide-modified screen-printed graphene electrodes (MnO2/SPGEs) were developed for the simultaneous electrochemical detection of coenzyme Q10 (CoQ10) and α-lipoic acid (ALA). This sensor exhibits attractive benefits such as simplicity, low production costs, and disposability. Cyclic voltammetry (CV) was used to characterize the electrochemical behavior of the analyte and investigate the capacitance and electroactive surface area of the unmodified and modified electrode surfaces...
April 3, 2018: Analytica Chimica Acta
https://www.readbyqxmd.com/read/29323033/coenzyme-q10-as-a-therapeutic-candidate-for-treating-inherited-photoreceptor-degeneration
#6
Xun Zhang, Lincoln Biswas, Ali Mohammad Tohari, James Reilly, Luca Tiano, Xinhua Shu
No abstract text is available yet for this article.
December 2017: Neural Regeneration Research
https://www.readbyqxmd.com/read/29322601/temperature-sensitivities-of-extracellular-enzyme-vmax-and-km-across-thermal-environments
#7
Steven D Allison, Adriana L Romero-Olivares, Ying Lu, John W Taylor, Kathleen K Treseder
The magnitude and direction of carbon cycle feedbacks under climate warming remain uncertain due to insufficient knowledge about the temperature sensitivities of soil microbial processes. Enzymatic rates could increase at higher temperatures, but this response could change over time if soil microbes adapt to warming. We used the Arrhenius relationship, biochemical transition state theory, and thermal physiology theory to predict the responses of extracellular enzyme Vmax and Km to temperature. Based on these concepts, we hypothesized that Vmax and Km would correlate positively with each other and show positive temperature sensitivities...
January 11, 2018: Global Change Biology
https://www.readbyqxmd.com/read/29321865/responses-of-soil-respiration-to-soil-management-changes-in-an-agropastoral-ecotone-in-inner-mongolia-china
#8
Haili Xue, Haiping Tang
Studying the responses of soil respiration (Rs) to soil management changes is critical for enhancing our understanding of the global carbon cycle and has practical implications for grassland management. Therefore, the objectives of this study were (1) quantify daily and seasonal patterns of Rs, (2) evaluate the influence of abiotic factors on Rs, and (3) detect the effects of soil management changes on Rs. We hypothesized that (1) most of daily and seasonal variation in Rs could be explained by soil temperature (Ts) and soil water content (Sw), (2) soil management changes could significantly affect Rs, and (3) soil management changes affected Rs via the significant change in abiotic and biotic factors...
January 2018: Ecology and Evolution
https://www.readbyqxmd.com/read/29305882/an-antioxidant-rich-novel-%C3%AE-amylase-from-peanuts-arachis-hypogaea-its-purification-biochemical-characterization-and-potential-applications
#9
Ranjana Das, Arvind M Kayastha
β-Amylase from un-germinated seeds of peanut (Arachis hypogaea) was purified to apparent electrophoretic homogeneity with final purification fold of 205 and specific activity of 361μmol/min/mg protein. The enzyme was purified employing simple purification techniques for biochemical characterization. The purified enzyme was identified as β-amylase with Mr of 31kDa. The enzyme displayed its optimum catalytic activity at pH5.0 and 60°C with activation energy of 4.5kcal/mol and Q10 1.2. The enzyme displayed Km and Vmax values, for soluble potato starch of 1...
January 3, 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29303137/comparison-of-icodextrin-with-thymoquinone-a-new-hope-for-postoperative-adhesions
#10
Ö Yilmaz, R Kiziltan, S Çelik, S Yildirm, H H Alp, A Aras, Ç Kotan
OBJECTIVE: The purpose of this study was to compare the effects of thymoquinone and icodextrin in rats within the framework of an experimental adhesion model. MATERIALS AND METHODS: Rats were separated into three groups: (1) a control group consisting of rats that had 2 ml of isotonic solution administered intraperitoneally, (2) an ICO group administered with 2 ml of 4% icodextrin, and (3) a TQ group administered thymoquinone (10 mg/kg), all following cecal abrasion...
November 2017: Nigerian Journal of Clinical Practice
https://www.readbyqxmd.com/read/29301117/cooperative-effects-of-q10-vitamin-d3-and-l-arginine-on-cardiac-and-endothelial-cells
#11
Claudio Molinari, Vera Morsanuto, Simona Polli, Francesca Uberti
This work demonstrates the cooperative effect of Q10, vitamin D3, and L-arginine on both cardiac and endothelial cells. The effects of Q10, L-arginine, and vitamin D3 alone or combined on cell viability, nitric oxide, and reactive oxygen species productions in endothelial and cardiac cells were studied. Moreover, the involvement of PI3K/Akt and ERK/MAPK pathways leading to eNOS activation as well as the involvement of vitamin D receptor were also investigated. The same agents were tested in an animal model to verify vasodilation, nitric oxide, and reactive oxygen species production...
January 5, 2018: Journal of Vascular Research
https://www.readbyqxmd.com/read/29300870/thermal-acclimation-of-photosynthesis-and-respiration-of-southern-and-northern-white-spruce-seed-sources-tested-along-a-regional-climatic-gradient-indicates-limited-potential-to-cope-with-temperature-warming
#12
Lahcen Benomar, Mohammed S Lamhamedi, Steeve Pepin, André Rainville, Marie-Claude Lambert, Hank A Margolis, Jean Bousquet, Jean Beaulieu
Background and Aims: Knowledge of thermal acclimation of physiological processes of boreal tree species is necessary to determine their ability to adapt to predicted global warming and reduce the uncertainty around the anticipated feedbacks of forest ecosystems and global carbon cycle to climate change. The objective of this work was to examine the extent of thermal acclimation of net photosynthesis (An) and dark respiration (Rd) of two distant white spruce (Picea glauca) seed sources (from south and north of the commerial forest zone in Québec) in response to latitudinal and seasonal variations in growing conditions...
December 29, 2017: Annals of Botany
https://www.readbyqxmd.com/read/29298622/oral-coenzyme-q10-supplementation-in-patients-with-migraine-effects-on-clinical-features-and-inflammatory-markers
#13
Monireh Dahri, Ali Tarighat-Esfanjani, Mohammad Asghari-Jafarabadi, Mazyar Hashemilar
BACKGROUNDS AND AIMS: Migraine and inflammation are correlated. Coenzyme Q10 (CoQ10) as an anti-inflammatory agent has shown useful effects in other diseases. The present study aimed to assess the effect of CoQ10 supplementation on inflammation and clinical features of migraine. METHODS: This randomized double-blind placebo-controlled clinical trial was conducted among 45 non-menopausal women aged 18-50 years, diagnosed for episodic migraine according to the International Headache Society...
January 3, 2018: Nutritional Neuroscience
https://www.readbyqxmd.com/read/29291430/the-potential-benefit-of-combined-versus-monotherapy-of-coenzyme-q10-and-fluoxetine-on-depressive-like-behaviors-and-intermediates-coupled-to-gsk-3%C3%AE-in-rats
#14
Sally A Abuelezz, Nevien Hendawy, Yosra Magdy
As a part of the serotoninergic dysfunction implicated in neurobiology of depression, evidence has focused on serotonin (5-HT) receptors downstream signaling intermediates including glycogen synthase kinase-3β (GSK-3β), cAMP response element binding protein (CREB) and brain derived neurotrophic factor (BDNF). Our team previously reported that coenzyme Q10 (CoQ10) exerted antidepressant-like effect in rats exposed to chronic unpredictable mid stress (CUMS) via elevating serotonin levels. However, the effect of CoQ10 has not been elucidated in downstream signaling molecules mediating 5HT receptors' effect involved in depressive disorder hitherto...
December 29, 2017: Toxicology and Applied Pharmacology
https://www.readbyqxmd.com/read/29289598/why-should-neuroscientists-worry-about-iron-the-emerging-role-of-ferroptosis-in-the-pathophysiology-of-neuroprogressive-diseases
#15
REVIEW
Gerwyn Morris, Michael Berk, André F Carvalho, Michael Maes, Adam J Walker, Basant K Puri
Ferroptosis is a unique form of programmed death, characterised by cytosolic accumulation of iron, lipid hydroperoxides and their metabolites, and effected by the fatal peroxidation of polyunsaturated fatty acids in the plasma membrane. It is a major driver of cell death in neurodegenerative neurological diseases. Moreover, cascades underpinning ferroptosis could be active drivers of neuropathology in major psychiatric disorders. Oxidative and nitrosative stress can adversely affect mechanisms and proteins governing cellular iron homeostasis, such as the iron regulatory protein/iron response element system, and can ultimately be a source of abnormally high levels of iron and a source of lethal levels of lipid membrane peroxidation...
December 28, 2017: Behavioural Brain Research
https://www.readbyqxmd.com/read/29288336/cytotoxicity-of-propofol-in-human-induced-pluripotent-stem-cell-derived-cardiomyocytes
#16
Koji Kido, Hiroyuki Ito, Yudai Yamamoto, Koshi Makita, Tokujiro Uchida
PURPOSE: Propofol infusion syndrome (PRIS) is a lethal condition caused by propofol overdose. Previous studies suggest that pathophysiological mechanisms underlying PRIS involve mitochondrial dysfunction; however, these mechanisms have not been fully elucidated. This study aimed to establish an experimental model of propofol-induced cytotoxicity using cultured human induced pluripotent stem cell (iPSC)-derived cardiomyocytes to determine the mechanisms behind propofol-induced mitochondrial dysfunction, and to evaluate the protective effects of coenzyme Q10 (CoQ10)...
December 29, 2017: Journal of Anesthesia
https://www.readbyqxmd.com/read/29285660/effect-of-blood-phenylalanine-levels-on-oxidative-stress-in-classical-phenylketonuric-patients
#17
Burcu Kumru, Davut Sinan Kaplan, Burcu Oztürk Hismi, Hakim Celik
Mental retardation, which occurs in phenylketonuric patients, is associated with increased levels of phenylalanine, increased oxidative stress, and an imbalance of amino acids in the brain. Recent studies have shown that oxidative stress plays a role in the pathogenesis of phenylketonuria. In this work, we aimed to compare the influence of blood phenylalanine levels on oxidative stress parameters in phenylketonuric patients who divided patients into groups according to blood Phe levels during follow-up visits and compared these groups with healthy controls...
December 28, 2017: Cellular and Molecular Neurobiology
https://www.readbyqxmd.com/read/29274518/one-step-treatment-and-resource-recovery-of-high-concentration-non-toxic-organic-wastewater-by-photosynthetic-bacteria
#18
Fan Meng, Anqi Yang, Hangyao Wang, Guangming Zhang, Xuemei Li, Yi Zhang, Zhiguo Zou
In order to achieve simple pollutant removal and simultaneous resource recovery in high-COD-non-toxic wastewater treatment, a one-step photosynthetic bacteria (PSB) method was established using batch study experiment. The effluent COD met the national discharge standard, and biomass with rich protein and high-value substances was efficiently produced. It eliminated the demand of post-treatment for conventional PSB treatment. Results showed that Rhodopseudomonas effectively treated brewery wastewater and achieved biomass proliferation...
December 6, 2017: Bioresource Technology
https://www.readbyqxmd.com/read/29258174/co-enzyme-q10-and-n-3-polyunsaturated-fatty-acid-supplementation-reverse-intermittent-hypoxia-induced-growth-restriction-and-improved-antioxidant-profiles-in-neonatal-rats
#19
Kay D Beharry, Charles L Cai, Michael M Henry, Sara Chowdhury, Gloria B Valencia, Jacob V Aranda
Neonatal intermittent hypoxia (IH) increases the risk for many morbidities in extremely low birth weight/gestational age (ELBW/ELGA) neonates with compromised antioxidant systems and poor growth. We hypothesized that supplementation with coenzyme Q10 (CoQ10, ubiquinol) or n-3 polyunsaturated fatty acids (PUFAs) during neonatal IH improves antioxidant profiles and somatic growth in neonatal rats. Newborn rats were exposed to two IH paradigms at birth (P0): (1) 50% O₂ with brief hypoxic episodes (12% O₂); or (2) room air (RA) with brief hypoxia, until P14 during which they received daily oral CoQ10 in olive oil, n-3 PUFAs in fish oil, or olive oil only from P0 to P14...
December 16, 2017: Antioxidants (Basel, Switzerland)
https://www.readbyqxmd.com/read/29246431/bypassing-human-coq10-deficiency
#20
Diran Herebian, Luis C López, Felix Distelmaier
Primary disorders of the human coenzyme Q10 (CoQ10) biosynthesis pathway are a known cause of severe pediatric diseases. So far, oral administration of CoQ10 is the only treatment strategy for affected individuals. However, the real benefit of CoQ10 supplementation remains questionable and clinical studies regarding efficiency are lacking. Here we provide an outlook on novel treatment approaches using CoQ precursor compounds. These metabolic bypass strategies might be a promising alternative for oral CoQ10 supplementation regimens...
December 9, 2017: Molecular Genetics and Metabolism
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