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https://www.readbyqxmd.com/read/28637167/effects-of-dissolved-oxygen-concentration-on-photosynthetic-bacteria-wastewater-treatment-pollutants-removal-cell-growth-and-pigments-production
#1
Fan Meng, Anqi Yang, Guangming Zhang, Hangyao Wang
Dissolved oxygen (DO) is an important parameter in photosynthetic bacteria (PSB) wastewater treatment. This study set different DO levels and detected the pollutants removal, PSB growth and pigments production. Results showed that DO significantly influenced the performances of PSB wastewater treatment process. The highest COD (93%) and NH3-N removal (83%) was achieved under DO of 4-8mg/L, but DO of 2-4mg/L was recommended considering the aeration cost. PSB biomass reached 1645mg/L under DO of 4-8mg/L with satisfying co-enzyme Q10 content...
June 1, 2017: Bioresource Technology
https://www.readbyqxmd.com/read/28623382/carbon-and-hydrogen-isotope-fractionation-during-aerobic-biodegradation-of-quinoline-and-3-methylquinoline
#2
Mingchao Cui, Wenbing Zhang, Jun Fang, Qianqiong Liang, Dongxuan Liu
Compound-specific isotope analysis has been used extensively to investigate the biodegradation of various organic pollutants. To date, little isotope fractionation information is available for the biodegradation of quinolinic compounds. In this study, we report on the carbon and hydrogen isotope fractionation during quinoline and 3-methylquinoline aerobic microbial degradation by a Comamonas sp. strain Q10. Degradation of quinoline and 3-methylquinoline was accompanied by isotope fractionation. Large hydrogen and small carbon isotope fractionation was observed for quinoline while minor carbon and hydrogen isotope fractionation effects occurred for 3-methylquinoline...
June 16, 2017: Applied Microbiology and Biotechnology
https://www.readbyqxmd.com/read/28613256/strawberry-based-cosmetic-formulations-protect-human-dermal-fibroblasts-against-uva-induced-damage
#3
Massimiliano Gasparrini, Tamara Y Forbes-Hernandez, Sadia Afrin, Patricia Reboredo-Rodriguez, Danila Cianciosi, Bruno Mezzetti, Josè L Quiles, Stefano Bompadre, Maurizio Battino, Francesca Giampieri
Extreme exposure of skin to Ultraviolet A (UVA)-radiation may induce a dysregulated production of reactive oxygen species (ROS) which can interact with cellular biomolecules leading to oxidative stress, inflammation, DNA damage, and alteration of cellular molecular pathways, responsible for skin photoaging, hyperplasia, erythema, and cancer. For these reasons, the use of dietary natural bioactive compounds with remarkable antioxidant activity could be a strategic tool to counteract these UVA-radiation-caused deleterious effects...
June 14, 2017: Nutrients
https://www.readbyqxmd.com/read/28609475/increase-in-insulin-like-growth-factor-1-igf-1-and-insulin-like-growth-factor-binding-protein-1-after-supplementation-with-selenium-and-coenzyme-q10-a-prospective-randomized-double-blind-placebo-controlled-trial-among-elderly-swedish-citizens
#4
Urban Alehagen, Peter Johansson, Jan Aaseth, Jan Alexander, Kerstin Brismar
BACKGROUND: Insulin-like growth factor-1(IGF-1) has a multitude of effects besides cell growth and metabolism. Reports also indicate anti-inflammatory and antioxidative effects. The concentrations of IGF-1 decrease with age and during inflammation. As selenium and coenzyme Q10 are involved in both the antioxidative defense and the inflammatory response, the present study aimed to examine the effects of supplementation with selenium and coenzyme Q10 on concentrations of IGF-1 and its binding protein IGFBP-1 in a population showing reduced cardiovascular mortality following such supplementation...
2017: PloS One
https://www.readbyqxmd.com/read/28603085/kaempferol-increases-levels-of-coenzyme-q-in-kidney-cells-and-serves-as-a-biosynthetic-ring-precursor
#5
Lucía Fernández-Del-Río, Anish Nag, Elena Gutiérrez Casado, Julia Ariza, Agape M Awad, Akil I Joseph, Ohyun Kwon, Eric Verdin, Rafael de Cabo, Claus Schneider, Jorge Z Torres, María I Burón, Catherine F Clarke, José M Villalba
Coenzyme Q (Q) is a lipid-soluble antioxidant essential in cellular physiology. Patients with Q deficiencies, with few exceptions, seldom respond to treatment. Current therapies rely on dietary supplementation with Q10, but due to its highly lipophilic nature, Q10 is difficult to absorb by tissues and cells. Plant polyphenols, present in the human diet, are redox active and modulate numerous cellular pathways. In the present study, we tested whether treatment with polyphenols affected the content or biosynthesis of Q...
June 9, 2017: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/28599221/metabolic-engineering-and-synthetic-biology-approaches-driving-isoprenoid-production-in-escherichia-coli
#6
Chonglong Wang, Bakht Zada, Gongyuan Wei, Seon-Won Kim
Isoprenoids comprise the largest family of natural organic compounds with many useful applications in the pharmaceutical, nutraceutical, and industrial fields. Rapid developments in metabolic engineering and synthetic biology have facilitated the engineering of isoprenoid biosynthetic pathways in Escherichia coli to induce high levels of production of many different isoprenoids. In this review, the stem pathways for synthesizing isoprene units as well as the branch pathways deriving diverse isoprenoids from the isoprene units have been summarized...
May 29, 2017: Bioresource Technology
https://www.readbyqxmd.com/read/28588434/maternal-uniparental-disomy-14-temple-syndrome-as-a-result-of-a-robertsonian-translocation
#7
Veronica Bertini, Antonella Fogli, Rossella Bruno, Alessia Azzarà, Angela Michelucci, Teresa Mattina, Silvano Bertelloni, Angelo Valetto
Maternal uniparental disomy of chromosome 14 (upd(14)mat) or Temple syndrome is an imprinting disorder associated with a relatively mild phenotype. The absence of specific congenital malformations makes this condition underdiagnosed in clinical practice. A boy with a de novo robertsonian translocation 45,XY,rob(13;14)(q10;q10) is reported; a CGH/SNP array showed a loss of heterozygosity in 14q11.2q13.1. The final diagnosis of upd(14)mat was made by microsatellite analysis, which showed a combination of heterodisomy and isodisomy for different regions of chromosome 14...
May 2017: Molecular Syndromology
https://www.readbyqxmd.com/read/28587914/the-chaoborus-pump-migrating-phantom-midge-larvae-sustain-hypolimnetic-oxygen-deficiency-and-nutrient-internal-loading-in-lakes
#8
Kam W Tang, Sabine Flury, Hans-Peter Grossart, Daniel F McGinnis
Hypolimnetic oxygen demand in lakes is often assumed to be driven mainly by sediment microbial processes, while the role of Chaoborus larvae, which are prevalent in eutrophic lakes with hypoxic to anoxic bottoms, has been overlooked. We experimentally measured the respiration rates of C. flavicans at different temperatures yielding a Q10 of 1.44-1.71 and a respiratory quotient of 0.84-0.98. Applying the experimental data in a system analytical approach, we showed that migrating Chaoborus larvae can significantly add to the water column and sediment oxygen demand, and contribute to the observed linear relationship between water column respiration and depth...
May 30, 2017: Water Research
https://www.readbyqxmd.com/read/28587702/protective-effects-of-coenzyme-q10-on-developmental-competence-of-porcine-early-embryos
#9
Shuang Liang, Ying Jie Niu, Kyung-Tae Shin, Xiang-Shun Cui
Coenzyme Q10 (Q10) plays an important role in the cellular antioxidant system by protecting the cells from free-radical oxidative damage and apoptosis. In the present study, we have investigated the effect of Q10 on the preimplantation development of porcine parthenogenetic embryos, as well as the underlying mechanism. The results showed that 100 μM was the optimal concentration of Q10, which resulted in significantly increased cleavage and blastocyst formation rates and improvement of blastocyst quality. Q10 improved the blastocyst hatching rate and cellular proliferation rate in hatching blastocysts and increased the expression of hatching-related genes...
June 7, 2017: Microscopy and Microanalysis
https://www.readbyqxmd.com/read/28579756/effect-of-a-food-supplement-containing-berberine-monacolin-k-hydroxytyrosol-and-coenzyme-q10-on-lipid-levels-a-randomized-double-blind-placebo-controlled-study
#10
Sergio D'Addato, Luciana Scandiani, Giuliana Mombelli, Francesca Focanti, Federica Pelacchi, Enrica Salvatori, Giorgio Di Loreto, Alessandro Comandini, Pamela Maffioli, Giuseppe Derosa
PURPOSE: To evaluate the ability of the new food supplement, Body Lipid (BL), containing red yeast rice, berberine, coenzyme Q10 and hydroxytyrosol, to lower the LDL-C in patients with mild-to-moderate hypercholesterolemia and to assess the overall safety profile of the product. METHODS: In this multicenter, randomized, double-blind, placebo and active comparator (the marketed Armolipid Plus(®) [AM]) controlled study, 158 hypercholesterolemic patients were randomized following a 4-week dietary run-in period...
2017: Drug Design, Development and Therapy
https://www.readbyqxmd.com/read/28577739/mitochondrial-cytopathies-and-the-kidney
#11
REVIEW
Francesco Emma, Leonardo Salviati
Mitochondrial cytopathies include a heterogeneous group of diseases that are characterized by impaired oxidative phosphorylation. Current evidence suggests that renal involvement is probably more frequent than originally suspected but remains subclinical in a significant number of patients or is underestimated due to the severity of other clinical manifestations. Until recently, these diseases were thought to develop primarily in pediatric patients but patients that become symptomatic only in adulthood are now well recognized...
April 2017: Néphrologie & Thérapeutique
https://www.readbyqxmd.com/read/28575781/estimation-of-global-soil-respiration-by-accounting-for-land-use-changes-derived-from-remote-sensing-data
#12
Minaco Adachi, Akihiko Ito, Seiichiro Yonemura, Wataru Takeuchi
Soil respiration is one of the largest carbon fluxes from terrestrial ecosystems. Estimating global soil respiration is difficult because of its high spatiotemporal variability and sensitivity to land-use change. Satellite monitoring provides useful data for estimating the global carbon budget, but few studies have estimated global soil respiration using satellite data. We provide preliminary insights into the estimation of global soil respiration in 2001 and 2009 using empirically derived soil temperature equations for 17 ecosystems obtained by field studies, as well as MODIS climate data and land-use maps at a 4-km resolution...
May 30, 2017: Journal of Environmental Management
https://www.readbyqxmd.com/read/28565869/mitochondrial-dysfunction-on-sinoatrial-node-and-pulmonary-vein-electrophysiological-activities
#13
Yung-Kuo Lin, Chen-Chuan Cheng, Min-Chien Tsai, Pei-Yu Wu, Yi-Ann Chen, Yao-Chang Chen, Shih-Ann Chen, Yi-Jen Chen
Atrial fibrillation (AF) is associated with mitochondrial dysfunction. Sinoatrial node (SAN) dysfunction increases arrhythmogenesis of pulmonary veins (PVs), which is the most important trigger of AF; however, it is not clear whether mitochondrial dysfunction differentially regulates electrical activity of SANs and PVs. In the present study, conventional microelectrodes were used to record the action potentials (APs) in isolated rabbit PVs, SANs, left atrium (LA) and right atrium (RA) before and after application of trifluorocarbonylcyanide phenylhydrazone (FCCP; a mitochondrial uncoupling agent) at 10, 100 and 300 nM...
May 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28560538/coenzyme-q10-and-niacin-mitigate-streptozotocin-induced-diabetic-encephalopathy-in-a-rat-model
#14
Tarek K Motawi, Hebatallah A Darwish, Manal A Hamed, Nagy S El-Rigal, Asmaa F Aboul Naser
Diabetic encephalopathy is an important complication of diabetes characterized by cognitive impairment, neurochemical and structural abnormalities. This study aimed to investigate the effect of coenzyme Q10 (CoQ10) and niacin as well as their combination in the treatment of encephalopathy associated with streptozotocin (STZ)- induced diabetes in rats. Glibenclamide (reference diabetic drug) and donepezil hydrochloride (acetylcholinesterase inhibitor) were also evaluated. Diabetes was induced by a single intraperitoneal injection of STZ (60 mg/kg)...
May 30, 2017: Metabolic Brain Disease
https://www.readbyqxmd.com/read/28553782/coenzyme-q10-protects-skeletal-muscle-from-ischemia-reperfusion-through-the-nf-kappa-b-pathway
#15
Mandana Beigi Boroujeni, Zahra Khanipour Khayat, Khatereh Anbari, Ali Niapour, Mohammadreza Gholami, Anneh Mohammad Gharravi
OBJECTIVE: Coenzyme Q10 (CoQ10) has antioxidant and anti-inflammatory activity. The aim of this study was to investigate the effects of CoQ10 on the inhibition of nuclear factor-kappa B (NF-κB) activation during ischemia-reperfusion (I/R) of skeletal muscle. METHODS: For ischemia induction, the animals were anesthetized and the external iliac vessels blocked for three hours. CoQ10 or vehicle was given intraperitoneally during ischemia, just before reperfusion. Four groups received 3,7,14 and 28 days' reperfusion, respectively, after the intraperitoneal injection of CoQ10 and four corresponding groups received vehicle only...
July 2017: Perfusion
https://www.readbyqxmd.com/read/28552678/detection-of-6-demethoxyubiquinone-in-coq10-deficiency-disorders-insights-into-enzyme-interactions-and-identification-of-potential-therapeutics
#16
Diran Herebian, Annette Seibt, Sander H J Smits, Gisela Bünning, Christoph Freyer, Holger Prokisch, Daniela Karall, Anna Wredenberg, Anna Wedell, Luis C López, Ertan Mayatepek, Felix Distelmaier
Coenzyme Q10 (CoQ10) is an essential cofactor of the mitochondrial oxidative phosphorylation (OXPHOS) system and its deficiency has important implications for several inherited metabolic disorders of childhood. The biosynthesis of CoQ10 is a complicated process, which involves at least 12 different enzymes. One of the metabolic intermediates that are formed during CoQ10 biosynthesis is the molecule 6-demethoxyubiquinone (6-DMQ). This CoQ precursor is processed at the level of COQ7 and COQ9. We selected this metabolite as a marker substance for metabolic analysis of cell lines with inherited genetic defects (COQ2, COQ4, COQ7 and COQ9) or siRNA knockdown in CoQ biosynthesis enzymes using ultra-performance liquid chromatography coupled to tandem mass spectrometry (UPLC-MS/MS)...
May 20, 2017: Molecular Genetics and Metabolism
https://www.readbyqxmd.com/read/28551782/mitochondrial-bioenergetics-and-dysfunction-in-failing-heart
#17
Freya L Sheeran, Salvatore Pepe
Energy insufficiency has been recognized as a key feature of systolic heart failure. Although mitochondria have long been known to sustain myocardial work energy supply, the capacity to therapeutically target mitochondrial bioenergetics dysfunction is hampered by a complex interplay of multiple perturbations that progressively compound causing myocardial failure and collapse. Compared to non-failing human donor hearts, activity rates of complexes I and IV, nicotinamide nucleotide transhydrogenase (NADPH-transhydrogenase, Nnt) and the Krebs cycle enzymes isocitrate dehydrogenase, malate dehydrogenase and aconitase are markedly decreased in end-stage heart failure...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/28549843/topical-coenzyme-q10-demonstrates-mitochondrial-mediated-neuroprotection-in-a-rodent-model-of-ocular-hypertension
#18
Benjamin Michael Davis, Kailin Tian, Milena Pahlitzsch, Jonathan Brenton, Nivedita Ravindran, Gibran Butt, Giulia Malaguarnera, Eduardo M Normando, Li Guo, M Francesca Cordeiro
Coenzyme Q10 (CoQ10) is a mitochondrial-targeted antioxidant with known neuroprotective activity. Its ocular effects when co-solubilised with α-tocopherol polyethylene glycol succinate (TPGS) were evaluated. In vitro studies confirmed that CoQ10 was significantly protective in different retinal ganglion cell (RGC) models. In vivo studies in Adult Dark Agouti (DA) rats with unilateral surgically-induced ocular hypertension (OHT) treated with either CoQ10/TPGS micelles or TPGS vehicle twice daily for three weeks were performed, following which retinal cell health was assessed in vivo using DARC (Detection of Apoptotic Retinal Cells) and post-mortem with Brn3a histological assessment on whole retinal mounts...
May 24, 2017: Mitochondrion
https://www.readbyqxmd.com/read/28546301/coenzyme-q10-supplementation-in-the-management-of-statin-associated-myalgia
#19
Jason T Tan, Arden R Barry
No abstract text is available yet for this article.
June 1, 2017: American Journal of Health-system Pharmacy: AJHP
https://www.readbyqxmd.com/read/28545145/respiratory-response-to-temperature-of-three-populations-of-aurelia-aurita-polyps-in-northern-europe
#20
Danja P Höhn, Cathy H Lucas, Sven Thatje
The benthic life stage (polyp or scyphistoma) of the bloom-forming jellyfish, Aurelia aurita (Linnaeus, 1759), also known as the moon jellyfish, contributes to the seasonal occurrence and abundance of medusa blooms via asexual reproduction. A. aurita is widely distributed in coastal areas in northern Europe, and one of the most studied jellyfish species. While the physiology of the visible medusa is largely understood, understanding of the physiology of the perennial benthic life-stage is scarce. To measure the physiological tolerance of A...
2017: PloS One
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