keyword
https://read.qxmd.com/read/19798040/thrombocytosis-in-neonates-and-young-infants-a-report-of-25-patients-with-platelet-counts-of-or-1000000-microl-1
#21
JOURNAL ARTICLE
S E Wiedmeier, E Henry, J Burnett, T Anderson, R D Christensen
OBJECTIVE: Thrombocytosis has been reported in neonates and young infants, but little is known of its prevalence, timing of onset, associated conditions, sequelae and outcomes. To better understand this condition, we used the data repositories of a multi-hospital health-care system to identify all individuals <or=140 days old (20 weeks) who, during the past 6 years, had a platelet count of >or=1000000 microl(-1). STUDY DESIGN: We identified all infants with extreme thrombocytosis (using the Sutor definition of a platelet count of >or=1000000 microl(-1)) during the period of January 2003 through December 2008 in any Intermountain Healthcare facility...
March 2010: Journal of Perinatology: Official Journal of the California Perinatal Association
https://read.qxmd.com/read/19711442/prolonged-acquired-neutropenia-in-children
#22
JOURNAL ARTICLE
Jiunn-Ming Sheen, Ho-Chang Kuo, Hong-Ren Yu, Eng-Yen Huang, Chih-Chiang Wu, Kuender D Yang
BACKGROUND: Acquired neutropenia is not uncommon in childhood. This study investigated the risk factors associated with developing prolonged acquired neutropenia. PROCEDURE: We reviewed 66,062 hospital admission medical records from the 5-year period January 1, 2002 to December 31, 2006 to identify neutropenic patients, with and without follow-up of their neutropenic course until December 31, 2007. After excluding patients with malignancy, collagen disease, bone marrow failure, prematurity, hereditary disease, congenital neutropenia, immunodeficiency, or status post-liver transplantation, 735 admissions with acquired neutropenia were included in our study...
December 15, 2009: Pediatric Blood & Cancer
https://read.qxmd.com/read/18818663/platelet-reference-ranges-for-neonates-defined-using-data-from-over-47-000-patients-in-a-multihospital-healthcare-system
#23
JOURNAL ARTICLE
S E Wiedmeier, E Henry, M C Sola-Visner, R D Christensen
OBJECTIVE: Identifying a platelet count as abnormal (thrombocytopenia or thrombocytosis) can facilitate recognizing various disease states. However, the published reference ranges for platelet counts in neonates may be imprecise, as they were generated from relatively small sample sizes and compiled before modern platelet enumeration methods. STUDY DESIGN: We derived new neonatal reference ranges for platelet counts and mean platelet volume (MPV) measurements using electronic data accumulated during a recent 6-year period from a multihospital healthcare system...
February 2009: Journal of Perinatology: Official Journal of the California Perinatal Association
https://read.qxmd.com/read/18802685/regional-cooling-of-the-extracorporeal-blood-circuit-a-novel-anticoagulation-approach-for-renal-replacement-therapy
#24
JOURNAL ARTICLE
Ales Krouzecky, Jiri Chvojka, Roman Sykora, Jaroslav Radej, Thomas Karvunidis, Ivan Novak, Jiri Ruzicka, Zuzana Petrankova, Jiri Benes, Lukas Bolek, Martin Matejovic
OBJECTIVE: To test the hypothesis that cooling of blood in the extracorporeal circuit of continuous veno-venous hemofiltration (CVVH) enables to realize the procedure without the need of anticoagulation. DESIGN: Experimental animal study. METHODS: We developed the device for selective cooling of extracorporeal circuit (20 degrees C) allowing blood rewarming (38 degrees C) just before returning into the body. Twelve anesthetized and ventilated pigs were randomized to receive either 6 h of CVVH with application of this device (COOL; n = 6) or without it (CONTR; n = 6)...
February 2009: Intensive Care Medicine
https://read.qxmd.com/read/16764090/anagrelide-new-drug-essential-thrombocythaemia-further-evaluation-needed-for-this-last-resort-treatment
#25
COMPARATIVE STUDY
(no author information available yet)
(1) For patients aged over 60 years who have essential thrombocythaemia, and are considered to be at increased risk of thromboembolism, the standard cytotoxic agent is hydroxycarbamide (hydroxyurea), which reduces the risk of thrombocytosis but adversely affects other blood cell lines. It may also increase the risk of progression to cancer. (2) Anagrelide, initially studied as an antiplatelet drug, was approved in Europe for the treatment of essential thrombocythaemia in high-risk patients when other treatments fail or are poorly tolerated...
June 2006: Prescrire International
https://read.qxmd.com/read/15647951/thrombocytosis-in-preterm-infants-a-possible-involvement-of-thrombopoietin-receptor-gene-expression
#26
JOURNAL ARTICLE
Hideki Nakayama, Kenji Ihara, Shunji Hikino, Junko Yamamoto, Taro Nagatomo, Megumi Takemoto, Toshiro Hara
Transient thrombocytosis is commonly observed in preterm infants after birth, but its physiological mechanism is still unknown. To understand the mechanism of the transient thrombocytosis in preterm infants we firstly evaluated a correlation between platelet counts and thrombopoietin (TPO) levels in preterm infants and next c-mpl mRNA levels on platelets in healthy preterm infants longitudinally during a half-year of life. The mean platelet counts in 45 very low birth weight infants (mean gestational age 27...
April 2005: Journal of Molecular Medicine: Official Organ of the "Gesellschaft Deutscher Naturforscher und Ärzte"
https://read.qxmd.com/read/15578031/patterns-of-thrombocytosis-and-thrombocytopenia-in-hospitalized-neonates
#27
JOURNAL ARTICLE
Ronald J McPherson, Sandra Juul
OBJECTIVE: We sought to identify changes in platelet (PLT) counts over time, and to evaluate the patterns of thrombocytopenia and thrombocytosis in hospitalized infants 23.8 weeks to term gestation. STUDY DESIGN: Neonates were divided into four gestational age groups and their PLT counts were retrospectively compared for prevalence of thrombocytopenia, thrombocytosis, and associated conditions. RESULTS: Postconceptional age, postnatal age, and sepsis (among other factors) affected PLT counts...
March 2005: Journal of Perinatology: Official Journal of the California Perinatal Association
https://read.qxmd.com/read/15034233/age-dependent-changes-in-the-incidence-and-etiology-of-childhood-thrombocytosis
#28
JOURNAL ARTICLE
Kousaku Matsubara, Takashi Fukaya, Hiroyuki Nigami, Hidekazu Harigaya, Takuya Hirata, Hideo Nozaki, Kunizo Baba
To determine the incidence and etiology of childhood thrombocytosis, over 15,000 platelet counts in 7,539 patients performed at a single regional hospital were reviewed. When thrombocytosis was defined as > or =500 x 10(9)/l of platelet counts, the condition could be diagnosed in 6.0% (456 cases) of the patients. All patients were classified as having secondary thrombocytosis. The incidence of thrombocytosis dramatically changed throughout child development; it was 12.5% in neonates, peaked to 35.8% in 1-month-old infants and then returned to 12...
2004: Acta Haematologica
https://read.qxmd.com/read/11843834/early-elevation-of-serum-thrombopoietin-levels-and-subsequent-thrombocytosis-in-healthy-preterm-infants
#29
JOURNAL ARTICLE
K Matsubara, K Baba, H Nigami, H Harigaya, A Ishiguro, T Kato, H Miyazaki
To verify pathophysiological mechanisms underlying thrombocytosis in low-birth-weight (LBW) preterm babies, we evaluated kinetic changes in platelet counts and thrombopoietic cytokines including thrombopoietin (TPO), interleukin 6 (IL-6) and IL-11 in 24 uncomplicated preterm infants. Platelet counts in cord blood (CB) (265 +/- 64 x 10(9)/l) were similar to adult levels, increased by d 14 (473 +/- 140 x 10(9)/l), and then remained fairly constant. Thrombocytosis (> 500 x 10(9)/l) was observed in 9/24 (38%) subjects...
December 2001: British Journal of Haematology
https://read.qxmd.com/read/11237230/meropenem-in-neonatal-severe-infections-due-to-multiresistant-gram-negative-bacteria
#30
JOURNAL ARTICLE
N Köksal, M Hacimustafaoğlu, S Bağci, S Celebi
Recently, new broad spectrum carbapenem has been investigated on a world-wide scale for the treatment of moderate to severe infections. In the neonatal intensive care units the extensive use of third generation cephalosporins for therapy of neonatal sepsis may lead to rapid emergence of multiresistant gram-negative organisms. We report the use of meropenem in 35 infants with severe infections due to Acinetobacter baumanii and Klebsiella pneumoniae. All gram negative bacteria were resistant to ampicillin, amoxicillin, ticarcilin, cefazoline, cefotaxime, ceftazidime, ceftriaxone and aminoglycosides...
January 2001: Indian Journal of Pediatrics
https://read.qxmd.com/read/10910539/thrombocytosis-in-children-at-one-medical-center-of-southern-taiwan
#31
JOURNAL ARTICLE
H L Chen, S S Chiou, J M Sheen, R C Jang, C C Lu, T T Chang
Thrombocytosis in children is common, but usually without symptoms. The causes of thrombocytosis in children are considered to be mostly due to infection, trauma, surgery, blood disease, prematurity, renal disease and chronic inflammation. To evaluate the incidence and etiology of thrombocytosis of the hospitalized patients, patients who were admitted to the Pediatric Department of Kaohsiung Medical College Hospital (KMCH) from October 1996 to November 1997 were studied. There were 2910 cases studied and 220 cases (127 male and 93 female) had thrombocytosis (> or = 500 x 10(9)/L) with a rate of 7...
September 1999: Acta Paediatrica Taiwanica, Taiwan Er Ke Yi Xue Hui za Zhi
https://read.qxmd.com/read/10828006/translational-pathophysiology-a-novel-molecular-mechanism-of-human-disease
#32
REVIEW
M Cazzola, R C Skoda
In higher eukaryotes, the expression of about 1 gene in 10 is strongly regulated at the level of messenger RNA (mRNA) translation into protein. Negative regulatory effects are often mediated by the 5'-untranslated region (5'-UTR) and rely on the fact that the 40S ribosomal subunit first binds to the cap structure at the 5'-end of mRNA and then scans for the first AUG codon. Self-complementary sequences can form stable stem-loop structures that interfere with the assembly of the preinitiation complex and/or ribosomal scanning...
June 1, 2000: Blood
https://read.qxmd.com/read/10790464/effect-of-early-versus-late-administration-of-human-recombinant-erythropoietin-on-transfusion-requirements-in-premature-infants-results-of-a-randomized-placebo-controlled-multicenter-trial
#33
RANDOMIZED CONTROLLED TRIAL
H Donato, N Vain, P Rendo, N Vivas, L Prudent, M Larguía, J Digregorio, C Vecchiarelli, R Valverde, C García, P Subotovsky, C Solana, A Gorenstein
OBJECTIVE: The administration of recombinant human erythropoietin (rHuEPO), started after the first 2 weeks of life, reduces the transfusion requirement in premature infants. However, its use throughout the first 2 weeks of life, when anemia results predominantly from phlebotomy losses, remains controversial. We investigated whether early use of rHuEPO would reduce the total transfusion requirement and/or the number of transfusions throughout the first 2 weeks of life. METHODS: We randomized 114 infants with birth weight (BW) <1250 g to receive rHuEPO (1250 units/kg/week; IV; early group: n = 57) or placebo (late group: n = 57) from day 2 to day 14 of life; subsequently, all the patients received rHuEPO (750 units/kg/week, subcutaneously) for 6 additional weeks...
May 2000: Pediatrics
https://read.qxmd.com/read/10771955/neonatal-klebsiella-pneumonia-sepsis-and-imipenem-cilastatin
#34
COMPARATIVE STUDY
R Oral, M Akisü, N Kültürsay, F Vardar, N Tansuğ
Efficacy and safety of imipenem/cilastatin in neonatal Klebsiella pneumonia sepsis was investigated in 45 infants compared to 39 control infants on conventional antibiotic regimen. Sensitivity to imipenem was 94% followed by cephoxitin (88%), quinolons (80%), and amikacin (52%) according to susceptibility results in the study group. Treatment duration of surviving infants was 16.5 +/- 4.6 and 20.3 +/- 6.4 days in the study and control groups respectively (p < 0.05). Five infants (11%) vs 27 (69%) were unresponsive (septic deaths) to treatment in the study and control groups respectively (p < 0...
January 1998: Indian Journal of Pediatrics
https://read.qxmd.com/read/10640221/fertility-pregnancy-and-the-management-of-myeloproliferative-disorders
#35
REVIEW
M Griesshammer, L Bergmann, T Pearson
The management of pregnant patients with chronic myeloproliferative disorders (MPD) is a difficult problem. Patients with essential thrombocythaemia (ET), and, less frequently, those with chronic myeloid leukaemia (CML) or polycythaemia vera (PV), present at a childbearing age. Pregnancy itself does not appear to affect adversely the natural course and prognosis of the MPD. However, fertility might be reduced, and an adverse outcome of pregnancy due to thrombotic or bleeding complications is a matter of concern...
December 1998: Baillière's Clinical Haematology
https://read.qxmd.com/read/10223933/safety-and-pharmacokinetics-of-an-intramuscular-monoclonal-antibody-sb-209763-against-respiratory-syncytial-virus-rsv-in-infants-and-young-children-at-risk-for-severe-rsv-disease
#36
RANDOMIZED CONTROLLED TRIAL
H C Meissner, J R Groothuis, W J Rodriguez, R C Welliver, G Hogg, P H Gray, R Loh, E A Simoes, P Sly, A K Miller, A I Nichols, D K Jorkasky, D E Everitt, K A Thompson
We conducted a multicenter, double-blind, placebo-controlled, randomized trial of a humanized monoclonal antibody against a respiratory syncytial virus (RSV) fusion protein (SB 209763) to evaluate its safety, pharmacokinetics, and fusion inhibition and neutralization titers. Forty-three infants who were either delivered prematurely (</=35 weeks' gestation) or exhibited bronchopulmonary dysplasia were administered either single or repeat (two doses, 8 weeks apart) intramuscular injections of SB 209763 at a concentration of 0...
May 1999: Antimicrobial Agents and Chemotherapy
https://read.qxmd.com/read/9439053/extensive-thrombophlebitis-with-reactive-thrombocytosis-in-a-high-risk-chinese-parturient-associated-with-retained-placenta-increta-a-case-report
#37
JOURNAL ARTICLE
C H Chen, C S Yin, T W Chu, T Y Chu, W H Chen, H S Hsiao
Postpartum thrombophlebitis is an infrequent disorder in Chinese women. A case is reported of extensive postpartum thrombophlebitis involving 23 cm of the femoral and pelvic veins. This 25-year-old splenectomized victim of beta-thalassemia was bedridden for 12 weeks because of threatened premature labor before Cesarean delivery. During the operation, placenta increta with massive bleeding was encountered. To save the uterus, ten percent of the placenta was retained. Duplex color Doppler imaging was performed for the diagnosis and follow-up of the thrombosis and vigorous anticoagulation therapy successfully cured this patient...
October 1997: Zhonghua Yi Xue za Zhi, Chinese Medical Journal; Free China Ed
https://read.qxmd.com/read/8588160/thrombocytosis-in-childhood
#38
REVIEW
A H Sutor
Until recently, thrombocytoses in childhood were considered to be rare. The literature on this subject is scarce and contradictory. When thrombocytosis is defined as a platelet count of more than 500 x 10(9)/L (500 000/mm3 or 500 000/microL), the occurrence in routine examinations at pediatric hospitals can be estimated as 3 to 13%. These are almost exclusively secondary thrombocytoses, which are the result of infections (most frequently), trauma and surgery, hypoxemia, immunologic disturbances, premature birth, gastrointestinal disorders, medications, stress situations, or previous loss of platelets...
1995: Seminars in Thrombosis and Hemostasis
https://read.qxmd.com/read/6507740/presidential-address-systemic-effects-of-smoking
#39
JOURNAL ARTICLE
R C Read
Millions of people continue to smoke. Recent studies confirm the pioneering epidemiologic data that indicated that, despite the well-established effects on the lung, most of the hundreds of thousands of premature deaths annually result from extrapulmonary toxicity, particularly accelerated cardiac and vascular disease. As with lung cancer, abstention significantly reduces the risk, even after myocardial infarction or surgery for complications of vascular disease. Erythrocytosis, thrombocytosis, and leukocytosis, by increasing blood viscosity, aggravate ischemia...
December 1984: American Journal of Surgery
https://read.qxmd.com/read/5696042/edema-and-hemolytic-anemia-in-premature-infants-a-vitamin-e-deficiency-syndrome
#40
JOURNAL ARTICLE
J H Ritchie, M B Fish, V McMasters, M Grossman
No abstract text is available yet for this article.
November 28, 1968: New England Journal of Medicine
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