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https://www.readbyqxmd.com/read/29237664/giant-retrocardiac-foregut-duplication-cyst-presenting-with-left-atrial-compression-and-palpitations
#1
Abdus Salam, Mujtaba Mubashir, Hadika Mubashir, Saulat Hasnain Fatimi
A 35-year-old man presented with a 3-month history of palpitations and shortness of breath. An ECG showed premature atrial contractions and episodes of supraventricular tachycardia. A subsequent echocardiogram showed a retrocardiac cystic mass that was compressing the left atrium. A CT scan confirmed these findings by showing a large left-sided posterior mediastinal cyst compressing the left atrium and pulmonary veins. The cyst was successfully excised from the retrocardiac position via left thoracotomy after which there was complete resolution of the palpitations...
December 13, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/29232013/what-are-the-medical-indications-for-providing-extremely-premature-infants-with-intensive-care
#2
EDITORIAL
Niels Lynøe, Gert Helgesson, Niklas Juth
No abstract text is available yet for this article.
December 12, 2017: Acta Paediatrica
https://www.readbyqxmd.com/read/29230337/prenatal-diagnosis-of-a-segmental-small-bowel-volvulus-with-threatened-premature-labor
#3
Barbara Monard, Nicolas Mottet, Rajeev Ramanah, Didier Riethmuller
Fetal primary small bowel volvulus is extremely rare but represents a serious life-threatening condition needing emergency neonatal surgical management to avoid severe digestive consequences. We report a case of primary small bowel volvulus with meconium peritonitis prenatally diagnosed at 27 weeks and 4 days of gestation during threatened premature labor with reduced fetal movements. Ultrasound showed a small bowel mildly dilated with thickened and hyperechogenic intestinal wall, with a typical whirlpool configuration...
2017: Case Reports in Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29229304/functional-characterization-of-the-g162r-and-d216h-genetic-variants-of-human-cyp17a1
#4
C P Capper, J Liu, L R McIntosh, J M Larios, M D Johnson, P F Hollenberg, Y Osawa, R J Auchus, J M Rae
Cytochrome P450 17A1 (CYP17A1) is a dual-function enzyme catalyzing reactions necessary for cortisol and androgen biosynthesis. CYP17A1 is a validated drug target for prostate cancer as CYP17A1 inhibition significantly reduces circulating androgens and improves survival in castration-resistant prostate cancer. Germline CYP17A1 genetic variants with altered CYP17A1 activity manifesting as various endocrinopathies are extremely rare; however, characterizing these variants provides critical insights into CYP17A1 protein structure and function...
December 8, 2017: Journal of Steroid Biochemistry and Molecular Biology
https://www.readbyqxmd.com/read/29229093/bronchopulmonary-dysplasia-a-review-of-pathogenesis-and-pathophysiology
#5
REVIEW
Renjithkumar Kalikkot Thekkeveedu, Milenka Cuevas Guaman, Binoy Shivanna
Bronchopulmonary dysplasia (BPD) is a chronic lung disease of primarily premature infants that results from an imbalance between lung injury and repair in the developing lung. BPD is the most common respiratory morbidity in preterm infants, which affects nearly 10, 000 neonates each year in the United States. Over the last two decades, the incidence of BPD has largely been unchanged; however, the pathophysiology has changed with the substantial improvement in the respiratory management of extremely low birth weight (ELBW) infants...
November 2017: Respiratory Medicine
https://www.readbyqxmd.com/read/29224247/cortisol-and-blood-pressure-levels-decreased-in-fathers-during-the-first-hour-of-skin-to-skin-contact-with-their-premature-babies
#6
Natalia Varela, Réjean Tessier, George Tarabulsy, Tamarha Pierce
AIM: Premature birth is an extremely stressful experience. In 2013 to 2014 we explored the physiological stress responses of fathers during their first skin-to-skin contact with their new baby. METHODS: We recruited 49 fathers whose partners had given birth to a premature baby of up to 33 weeks and three days. The study, in the neonatal intensive care unit (NICU) of a Quebec hospital, measured the physiological stress responses of the fathers before and after they first experienced skin-to-skin contact with their new baby...
December 9, 2017: Acta Paediatrica
https://www.readbyqxmd.com/read/29223461/antenatal-consultations-at-extreme-prematurity-a-systematic-review-of-parent-communication-needs
#7
Ashraf Kharrat, Gregory P Moore, Stéphanie Beckett, Stuart G Nicholls, Margaret Sampson, Thierry Daboval
OBJECTIVE: To synthesize and describe parental expectations on how healthcare professionals should interact with them during a peripartum, antenatal consultation for extremely preterm infants. STUDY DESIGN: For this systematic literature review with textual narrative synthesis, we included studies that explored parental perspectives regarding the antenatal consultation for an extremely preterm infant. Electronic searches of Medline, CINAHL, PsycInfo, and Embase were conducted, along with a search of the grey literature...
December 6, 2017: Journal of Pediatrics
https://www.readbyqxmd.com/read/29219103/climate-change-impacts-on-human-health-over-europe-through-its-effect-on-air-quality
#8
REVIEW
Ruth M Doherty, Mathew R Heal, Fiona M O'Connor
This review examines the current literature on the effects of future emissions and climate change on particulate matter (PM) and O3 air quality and on the consequent health impacts, with a focus on Europe. There is considerable literature on the effects of climate change on O3 but fewer studies on the effects of climate change on PM concentrations. Under the latest Intergovernmental Panel on Climate Change (IPCC) 5th assessment report (AR5) Representative Concentration Pathways (RCPs), background O3 entering Europe is expected to decrease under most scenarios due to higher water vapour concentrations in a warmer climate...
December 5, 2017: Environmental Health: a Global Access Science Source
https://www.readbyqxmd.com/read/29207684/recurrent-glioma-clinical-trial-checkmate-143-the-game-is-not-over-yet
#9
REVIEW
Anna C Filley, Mario Henriquez, Mahua Dey
Glioblastoma (GBM) is the most common, and aggressive, primary brain tumor in adults. With a median patient survival of less than two years, GBM represents one of the biggest therapeutic challenges of the modern era. Even with the best available treatment, recurrence rates are nearly 100% and therapeutic options at the time of relapse are extremely limited. Nivolumab, an anti-programmed cell death-1 (PD-1) monoclonal antibody, has provided significant clinical benefits in the treatment of various advanced cancers and represented a promising therapy for primary and recurrent GBM...
October 31, 2017: Oncotarget
https://www.readbyqxmd.com/read/29205169/potential-for-thermal-damage-to-the-blood-brain-barrier-during-craniotomy-procedure-implications-for-intracortical-recording-microelectrodes
#10
Andrew Shoffstall, Jennifer Paiz, David Miller, Griffin Rial, Mitchell Willis, Dhariyat Menendez, Stephen Hostler, Jeffrey R Capadona
Our objective was to determine how readily blood-brain barrier (BBB) disruption occurred as a result of bone drilling during a craniotomy to implant microelectrodes in rat cortex. While the phenomenon of heat production during bone-drilling is well-known, practices to evade damage to the underlying brain tissue are inconsistently practiced and reported in the literature. Approach: We conducted a review of intracortical microelectrode literature to summarize typical approaches to mitigate drill heating during rodent craniotomies...
December 5, 2017: Journal of Neural Engineering
https://www.readbyqxmd.com/read/29202809/five-years-follow-up-of-dental-fear-and-anxiety-experience-of-dental-care-and-oral-health-behaviour-in-swedish-preterm-and-full-term-adolescents
#11
Susanne Brogårdh-Roth, Johanna Månsson, Karin Ridell, Lubna Alward, Kristina Hellén-Halme, EwaCarin Ekberg
BACKGROUND: There is rising concern about how preterm birth affects long-term health later in life. The various effects that preterm birth have on developmental outcomes, cognitive profiles and medical health may also affect levels of cooperation in the dental care situation in addition to general oral health and other oral health-related habits. Oral health is an integral part of one's general health and well-being; however, less is known about how prematurity affects oral health and other related areas such as dental care, and including dental fear and anxiety (DFA) in individuals during adolescence and adulthood...
December 4, 2017: BMC Oral Health
https://www.readbyqxmd.com/read/29199204/definitive-diagnosis-of-mandibular-hypoplasia-deafness-progeroid-features-and-lipodystrophy-mdpl-syndrome-caused-by-a-recurrent-de-novo-mutation-in-the-pold1-gene
#12
Haruka Sasaki, Kumiko Yanagi, Satoshi Ugi, Kunihisa Kobayashi, Kumiko Ohkubo, Yuji Tajiri, Hiroshi Maegawa, Atsunori Kashiwagi, Tadashi Kaname
Segmental progeroid syndromes with lipodystrophy are extremely rare, heterogeneous, and complex multi-system disorders that are characterized by phenotypic features of premature aging affecting various tissues and organs. In this study, we present a "sporadic/isolated" Japanese woman who was ultimately diagnosed with mandibular hypoplasia, deafness, progeroid features, and progressive lipodystrophy (MDPL) syndrome (MIM #615381) using whole exome sequencing analysis. She had been suspected as having atypical Werner syndrome and/or progeroid syndrome based on observations spanning a 30-year period; however, repeated genetic testing by Sanger sequencing did not identify any causative mutation related to various subtypes of congenital partial lipodystrophy (CPLD) and/or mandibular dysplasia with lipodystrophy (MAD)...
December 2, 2017: Endocrine Journal
https://www.readbyqxmd.com/read/29195509/dpp-4-inhibition-with-linagliptin-ameliorates-the-progression-of-premature-aging-in-klotho-mice
#13
Yu Hasegawa, Kenyu Hayashi, Yushin Takemoto, Cao Cheng, Koki Takane, Bowen Lin, Yoshihiro Komohara, Shokei Kim-Mitsuyama
BACKGROUND: The potential of anti-aging effect of DPP-4 inhibitors is unknown. This study was performed to determine whether linagliptin, a DPP-4 inhibitor, could protect against premature aging in klotho-/- mice. METHODS: Klotho-/- mice exhibit multiple phenotypes resembling human premature aging, including extremely shortened life span, cognitive impairment, hippocampal neurodegeneration, hair loss, muscle atrophy, hypoglycemia, etc. To investigate the effect of linagliptin on these aging-related phenotypes, male klotho-/- mice were divided into two groups: (1) control group fed the standard diet, and (2) linagliptin group fed the standard diet containing linagliptin...
December 1, 2017: Cardiovascular Diabetology
https://www.readbyqxmd.com/read/29191725/bonding-in-neonatal-intensive-care-units-experiences-of-extremely-preterm-infants-mothers
#14
Isabel María Fernández Medina, José Granero-Molina, Cayetano Fernández-Sola, José Manuel Hernández-Padilla, Marcos Camacho Ávila, María Del Mar López Rodríguez
BACKGROUND: The birth of an extremely preterm infant can disrupt normal mother-infant physical contact and the care provided by the mother. This situation has an impact on the process of bonding between the mother and the child. AIM: The objective of this study was to describe and understand the experiences of mothers who have extremely preterm infants admitted in Neonatal Intensive Care Units with regard to their bonding process. METHODS: An interpretive, qualitative research methodology using Gadamer's philosophical hermeneutics was carried out...
November 27, 2017: Women and Birth: Journal of the Australian College of Midwives
https://www.readbyqxmd.com/read/29183024/should-all-extremely-premature-infants-be-screened-for-pulmonary-hypertension
#15
Karen C Young, Eduardo Bancalari
No abstract text is available yet for this article.
November 29, 2017: Neonatology
https://www.readbyqxmd.com/read/29181530/neurodevelopmental-and-behavioral-outcomes-in-extremely-premature-neonates-with-ventriculomegaly-in-the-absence-of-periventricular-intraventricular-hemorrhage
#16
Athina Pappas, Ira Adams-Chapman, Seetha Shankaran, Scott A McDonald, Barbara J Stoll, Abbot R Laptook, Waldemar A Carlo, Krisa P Van Meurs, Susan R Hintz, Martha D Carlson, Jane E Brumbaugh, Michele C Walsh, Myra H Wyckoff, Abhik Das, Rosemary D Higgins
Importance: Studies of cranial ultrasonography and early childhood outcomes among cohorts of extremely preterm neonates have linked periventricular-intraventricular hemorrhage and cystic periventricular leukomalacia with adverse neurodevelopmental outcomes. However, the association between nonhemorrhagic ventriculomegaly and neurodevelopmental and behavioral outcomes is not fully understood. Objective: To characterize the outcomes of extremely preterm neonates younger than 27 weeks' gestational age who experienced nonhemorrhagic ventriculomegaly that was detected prior to 36 weeks' postmenstrual age...
November 27, 2017: JAMA Pediatrics
https://www.readbyqxmd.com/read/29181441/the-severity-of-retinopathy-in-the-extremely-premature-infants
#17
Alexandra Trivli, Maria Polychronaki, Charoula Matalliotaki, Michail Papadimas, Athina E Patelarou, Niki Dermitzaki, Michail Matalliotakis
Objective: We aimed to investigate the incidence and the severity of retinopathy of extremely premature infants and to evaluate the risk factors and outcome of the cases. Materials and Methods: Out of 200 premature births, we retrospectively reviewed 9 cases that developed ROP. We excluded cases where ROP developed in newborns > 30 weeks of gestational age and cases where medical notes were unavailable or incomplete. Topical drops of cyclopentolate 1% and phenylephrine 5% were instilled and fundoscopy was performed using a direct ophthalmoscope...
2017: International Scholarly Research Notices
https://www.readbyqxmd.com/read/29181020/chaos-quantum-behaved-cat-swarm-optimization-algorithm-and-its-application-in-the-pv-mppt
#18
Xiaohua Nie, Wei Wang, Haoyao Nie
Cat Swarm Optimization (CSO) algorithm was put forward in 2006. Despite a faster convergence speed compared with Particle Swarm Optimization (PSO) algorithm, the application of CSO is greatly limited by the drawback of "premature convergence," that is, the possibility of trapping in local optimum when dealing with nonlinear optimization problem with a large number of local extreme values. In order to surmount the shortcomings of CSO, Chaos Quantum-behaved Cat Swarm Optimization (CQCSO) algorithm is proposed in this paper...
2017: Computational Intelligence and Neuroscience
https://www.readbyqxmd.com/read/29174374/tracheobronchial-stenting-for-airway-malacia
#19
REVIEW
Colin Wallis, Clare A McLaren
Tracheobronchomalacia is a rare but clinically troublesome condition in paediatrics. The softening of the major airways - which can include some or all of the tracheobronchial tree can lead to symptoms ranging from the minor (harsh barking cough, recurrent chest infections) to severe respiratory difficulties including prolonged ventilator support and 'near death attacks'. The causes are broadly divided into intrinsic softening of the airway wall which is considered a primary defect (e.g. syndromes; post tracheo-oesophageal fistula repair; extreme prematurity) or secondary malacia due to external compression from vascular structures or cardiac components...
October 13, 2017: Paediatric Respiratory Reviews
https://www.readbyqxmd.com/read/29173320/pulmonary-artery-pressures-in-school-age-children-born-prematurely
#20
Sanja Zivanovic, Kuberan Pushparajah, Sandy Calvert, Neil Marlow, Reza Razavi, Janet L Peacock, Anne Greenough
OBJECTIVES: To test the hypothesis that pulmonary artery pressures were higher in school aged children born extremely premature than those born at term. We also wanted to assess whether pulmonary artery pressures differed between children born prematurely with or without bronchopulmonary dysplasia (BPD) or between those randomized in the neonatal period to different ventilation modes. STUDY DESIGN: Transthoracic echocardiography was performed on 193 children born extremely premature (106 had BPD) and 110 children born at term when they were 11-14 years of age...
December 2017: Journal of Pediatrics
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