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https://www.readbyqxmd.com/read/29475132/differential-effects-of-short-chain-fatty-acids-on-endothelial-nlrp3-inflammasome-activation-and-neointima-formation-antioxidant-action-of-butyrate
#1
Xinxu Yuan, Lei Wang, Owais M Bhat, Hannah Lohner, Pin-Lan Li
Short chain fatty acids (SCFAs), a family of gut microbial metabolites, have been reported to promote preservation of endothelial function and thereby exert anti-atherosclerotic action. However, the precise mechanism mediating this protective action of SCFAs remains unknown. The present study investigated the effects of SCFAs (acetate, propionate and butyrate) on the activation of Nod-like receptor pyrin domain 3 (Nlrp3) inflammasome in endothelial cells (ECs) and associated carotid neointima formation. Using a partial ligated carotid artery (PLCA) mouse model fed with the Western diet (WD), we found that butyrate significantly decreased Nlrp3 inflammasome formation and activation in the carotid arterial wall of wild type mice (Asc+/+ ), which was comparable to the effect of gene deletion of the adaptor protein apoptosis-associated speck-like protein gene (Asc-/- )...
February 13, 2018: Redox Biology
https://www.readbyqxmd.com/read/29474103/hypolipidemic-and-antidiabetic-effects-of-functional-rice-cookies-in-high-fat-diet-fed-icr-mice-and-db-db-mice
#2
Sun Hee Hong, Minji Woo, Mijeong Kim, Yeong Ok Song
We have previously reported the lipid-lowering effects of a Korean rice cookie called dasik (RCD) in comparison with a western style cookie. In this study, Schisandra chinensis (Turcz.) Baill. (Chinese magnolia vine) fruit-supplemented RCD (SRCD) was added to a diet, and the hypolipidemic and antidiabetic effects of different diets were examined by using the ICR and db/db mouse models, respectively. ICR mice were fed the AIN-76 diet, or high-fat diet (HFD), or the RCD- or SRCD-supplemented HFD (10%, w/w) for 9 weeks (n = 7 per group)...
February 23, 2018: Journal of Medicinal Food
https://www.readbyqxmd.com/read/29473892/gender-differences-in-the-association-between-dietary-pattern-and-the-incidence-of-hypertension-in-middle-aged-and-older-adults
#3
SuJin Song, Jiwon Kim, Jihye Kim
We examined gender differences in the association between dietary patterns and the risk of hypertension, using the Korean Genome and Epidemiology Study data. A total of 5090 participants (2457 men and 2633 women) aged 40-69 years without hypertension at baseline were selected. Dietary patterns were obtained using factor analysis based on 26 food groups, evaluated by a validated semi-quantitative food frequency questionnaire at baseline. Hypertension was defined as systolic blood pressure ≥ 140 mmHg or diastolic blood pressure ≥ 90 mmHg, or the use of antihypertensive medication using the biennial measurements...
February 23, 2018: Nutrients
https://www.readbyqxmd.com/read/29473362/-effects-of-electroacupuncture-on-expression-of-cd36-in-peritoneal-macrophages-of-rabbits-with-atherosclerosis
#4
Zedong Cheng, Yulou Ning, Rui Wang
OBJECTIVE: To observe the effect of electroacupuncture (EA) on the expressions of CD36 gene and protein in peritoneal macrophages of atherosclerotic rabbits, and to explore the mechanism of acupuncture regulation of atherosclerosis. METHODS: A total of 26 male New Zealand rabbits were randomly divided into a blank group (7 rabbits) and a model group (19 rabbits). The rabbits in the blank group were fed with common feedstuff, and those in the model group were applied with high fat diet and arteria carotis communis bullon injury...
February 12, 2018: Zhongguo Zhen Jiu, Chinese Acupuncture & Moxibustion
https://www.readbyqxmd.com/read/29472517/nordihydroguaiaretic-acid-a-lignan-from-larrea-tridentata-creosote-bush-protects-against-alios-diet-induced-metabolic-dysfunction-in-mice
#5
Jackie K W Chan, Stefanie Bittner, Alex Bittner, Suman Atwal, Wen-Jun Shen, Mohammed Inayathullah, Jayakumar Rajada, Mark R R Nicolls, Fredric B Kraemer, Salman Azhar
To determine the effects of NDGA on metabolic and molecular changes in response to feeding mice typical American fast food or Western diet, mice were fed with ALIOS diet and subjected to metabolic analysis. Male C57BL/6J mice were randomly assigned to: ALIOS, ALIOS + NDGA, or control diet and maintained on the specific diet for 8 weeks. Mice fed ALIOS diet, showed increased body, liver and epididymal fat pad weight, plasma ALT and AST levels (a measure of liver injury), and liver triglyceride (TG) content. Co-administration of NDGA normalized body and epididymal fat pad weight, ALT and AST levels, and liver TG...
February 22, 2018: Journal of Pharmacology and Experimental Therapeutics
https://www.readbyqxmd.com/read/29471014/epigenomic-drugs-and-the-germline-collateral-damage-in-the-home-of-heritability
#6
REVIEW
Patrick S Western
The testis and ovary provide specialised environments that nurture germ cells and facilitate their maturation, culminating in the production of mature gametes that can found the following generation. The sperm and egg not only transmit genetic information, but also epigenetic modifications that affect the development and physiology of offspring. Importantly, the epigenetic information contained in mature sperm and oocytes can be influenced by a range of environmental factors, such as diet, chemicals and drugs...
February 19, 2018: Molecular and Cellular Endocrinology
https://www.readbyqxmd.com/read/29470816/hepatic-subcellular-distribution-of-squalene-changes-according-to-the-experimental-setting
#7
Roberto Martínez-Beamonte, Olga Alda, Teresa Sanclemente, María J Felices, Sara Escusol, Carmen Arnal, Luis V Herrera-Marcos, Sonia Gascón, Joaquín C Surra, Jesús Osada, Mª Jesús Rodríguez-Yoldi
Squalene is the main unsaponifiable component of virgin olive oil, the main source of dietary fat in Mediterranean diet, traditionally associated with a less frequency of cardiovascular diseases. In this study, two experimental approaches were used. In the first, New Zealand rabbits fed for 4 weeks with a chow diet enriched in 1% sunflower oil for the control group, and in 1% of sunflower oil and 0.5% squalene for the squalene group. In the second, APOE KO mice received either Western diet or Western diet enriched in 0...
February 22, 2018: Journal of Physiology and Biochemistry
https://www.readbyqxmd.com/read/29468518/cultural-factors-influencing-osteoarthritis-care-in-asian-communities-a-review-of-the-evidence
#8
REVIEW
Thrmiga Sathiyamoorthy, Shabana Amanda Ali, Marita Kloseck
With the prevalence of osteoarthritis (OA) increasing internationally, there is a need to study the impact of this disease on culturally diverse populations. Individuals of Asian descent make up more than 60% of the world population, yet comprehensive information on the cultural factors that impact OA care is not available. Scoping review methodology using directed content analysis was employed to identify and analyze existing research on OA care for Asians. A categorization matrix was developed using the six care areas from the OA clinical practice guidelines along with an additional three non-clinical areas (cross-cultural adaptation of clinical tools; psychological well-being; family systems and informal care) identified in an initial scan resulting in a total of nine OA care areas to guide initial coding...
February 21, 2018: Journal of Community Health
https://www.readbyqxmd.com/read/29466028/analysis-of-the-impact-of-common-polymorphisms-of-the-fto-and-mc4r-genes-with-the-risk-of-severe-obesity-in-saudi-arabian-population
#9
Cyril Cyrus, Mona H Ismail, Shahanas Chathoth, Chittibabu Vatte, Majd Hasen, Amein Al Ali
BACKGROUND: Obesity has reached epidemic proportions worldwide resulting in a serious public health problem. In Saudi Arabia, 28.7% of the population is obese due largely to the adoption of western dietary patterns over the last decade. The Fat-mass and obesity associated (FTO) and melanocortin-4 receptor (MC4R) genes are ubiquitously expressed in the brain and pancreatic islets, and are the main link between the central nervous system and energy homeostasis based on food intake and energy expenditure...
February 21, 2018: Genetic Testing and Molecular Biomarkers
https://www.readbyqxmd.com/read/29464019/the-involvement-of-serum-exosomal-mir-500-3p-and-mir-770-3p-in-aging-modulation-by-calorie-restriction
#10
Eun Kyeong Lee, Hyoung Oh Jeong, Eun Jin Bang, Chul Hong Kim, Ji Young Mun, Seulgi Noh, Jeong-An Gim, Dae Hyun Kim, Ki Wung Chung, Byung Pal Yu, Hae Young Chung
Recent studies have shown a role for miRNAs in aging and age-related diseases, and the modulation of miRNA expression by diet attracts attention as a new therapeutic strategy. Here, we focused on identifying specific exosomal miRNAs derived from serum of aged rats and the effect of short-term calorie restriction (CR) on their expression. Exosomes from serum of young (7-month), old (22-month), and old-CR Sprague Dawley rats were isolated and characterized by transmission electron microscopy analyses, dynamic light scattering measurements, and Western blotting...
January 19, 2018: Oncotarget
https://www.readbyqxmd.com/read/29462978/impact-of-western-and-mediterranean-diets-and-vitamin-d-on-muscle-fibers-of-sedentary-rats
#11
Francesca Maria Trovato, Paola Castrogiovanni, Marta Anna Szychlinska, Francesco Purrello, Giuseppe Musumeci
BACKGROUND: The metabolic syndrome is associated with sarcopenia. Decreased serum levels of Vitamin D (VitD) and insulin-like growth factor (IGF)-1 and their mutual relationship were also reported. We aimed to evaluate whether different dietary profiles, containing or not VitD, may exert different effects on muscle molecular morphology. METHODS: Twenty-eight male rats were fed for 10 weeks in order to detect early defects induced by different dietary regimens: regular diet (R); regular diet with vitamin D supplementation (R-DS) and regular diet with vitamin D restriction (R-DR); high-fat butter-based diets (HFB-DS and HFB-DR) with 41% energy from fat; high-fat extra-virgin olive oil-based diets (HFEVO-DS and HFEVO-DR) with 41% energy from fat...
February 17, 2018: Nutrients
https://www.readbyqxmd.com/read/29460812/the-acute-effect-of-black-tea-consumption-on-resistance-artery-endothelial-function-in-healthy-subjects-a-randomized-controlled-trial
#12
Arno Greyling, Thalijn L C Wolters, David M de Bresser, Sean H P P Roerink, Niels P Riksen, Theo P Mulder, Matthew J Rowson, Maria T Hopman, Dick H J Thijssen
BACKGROUND & AIMS: Black tea is a main source of flavonoids in the Western diet and has been associated with reduced risk for cardiovascular disease, possibly through lowering blood pressure. These effects may be mediated through improving endothelial function of resistance arteries. The aim of this study was therefore to examine the acute impact of black tea on forearm resistance artery endothelial function in healthy, normotensive middle-aged subjects. METHODS: Twenty middle-aged men and women (age-range 45-75 years) were recruited into a double-blind, randomized, placebo-controlled crossover intervention study...
February 2018: Clinical Nutrition ESPEN
https://www.readbyqxmd.com/read/29460474/specific-synbiotics-in-early-life-protect-against-diet-induced-obesity-in-adult-mice
#13
Mona Mischke, Tulika Arora, Sebastian Tims, Eefje Engels, Nina Sommer, Kees van Limpt, Annemarie Baars, Raish Oozeer, Annemarie Oosting, Fredrik Bäckhed, Jan Knol
AIMS: The metabolic state of human adults is associated with their gut microbiome. The symbiosis between host and microbiome is initiated at birth, and early life microbiome perturbation can disturb health long-lastingly. Here, we determined how beneficial microbiome interventions in early life affect metabolic health in adulthood. METHODS: Postnatal diets were supplemented with either prebiotics (scGOS/lcFOS) or synbiotics (scGOS/lcFOS with Bifidobacterium breve M-16V) until post-natal (PN) day 42 in a well-established rodent model for nutritional programming...
February 20, 2018: Diabetes, Obesity & Metabolism
https://www.readbyqxmd.com/read/29459911/effects-of-a-12-week-high-%C3%AE-linolenic-acid-intervention-on-epa-and-dha-concentrations-in-red-blood-cells-and-plasma-oxylipin-pattern-in-subjects-with-a-low-epa-and-dha-status
#14
Theresa Greupner, Laura Kutzner, Fabian Nolte, Alena Strangmann, Heike Kohrs, Andreas Hahn, Nils Helge Schebb, Jan Philipp Schuchardt
The essential omega-3 fatty acid alpha-linolenic acid (ALA, 18:3n3) can be converted into EPA and DHA. The aim of the present study was to determine the effect of a high-ALA diet on EPA and DHA levels in red blood cells (RBCs) and their oxylipins in the plasma of subjects with a low EPA and DHA status. Fatty acid concentrations [μg mL-1 ] and relative amounts [% of total fatty acids] in the RBCs of 19 healthy men (mean age 26.4 ± 4.6 years) were analyzed by means of GC-FID. Free plasma oxylipin concentrations were determined by LC-MS based targeted metabolomics...
February 20, 2018: Food & Function
https://www.readbyqxmd.com/read/29459359/impact-of-dietary-patterns-and-the-main-food-groups-on-mortality-and-recurrence-in-cancer-survivors-a-systematic-review-of-current-epidemiological-literature
#15
Sylvia H J Jochems, Frits H M Van Osch, Richard T Bryan, Anke Wesselius, Frederik J van Schooten, Kar Keung Cheng, Maurice P Zeegers
OBJECTIVE: To determine whether there is an association between dietary patterns/indices and foods from the main food groups (highest vs lowest intakes) prior to or after cancer diagnosis and mortality and cancer recurrence in cancer survivors. PARTICIPANTS: Survivors of common cancers with a 10-year survival rate of ≥50%: bladder, bowel, breast, cervical, kidney, laryngeal, prostate, testicular, uterine cancer, malignant melanoma and (non-)Hodgkin's lymphoma...
February 19, 2018: BMJ Open
https://www.readbyqxmd.com/read/29459263/hyperlipidemia-induces-typical-atherosclerosis-development-in-ldlr-and-apoe-deficient-rats
#16
Yongliang Zhao, Yiqing Yang, Roumei Xing, Xueqin Cui, Yufang Xiao, Ling Xie, Panpan You, Tongtong Wang, Li Zeng, Wenhui Peng, Dali Li, Huaqing Chen, Mingyao Liu
BACKGROUND AND AIMS: Low-density lipoprotein receptor (Ldlr) and apolipoprotein E (Apoe) knockout (KO) mice have been widely used as animal models of atherosclerosis. However, data suggested that it is difficult to develop typical atherosclerosis in rats. To this end, Ldlr and Apoe KO rats were generated and the potential to develop novel atherosclerosis models was evaluated. METHODS: We established Apoe/Ldlr single and double KO (DKO) rats via the CRISPR/Cas9 system in the same background...
February 12, 2018: Atherosclerosis
https://www.readbyqxmd.com/read/29459262/soluble-endoglin-and-hypercholesterolemia-aggravate-endothelial-and-vessel-wall-dysfunction-in-mouse-aorta
#17
Barbora Vitverova, Katerina Blazickova, Iveta Najmanova, Matej Vicen, Radek Hyšpler, Eva Dolezelova, Ivana Nemeckova, Jurjen Duintjer Tebbens, Carmelo Bernabeu, Miguel Pericacho, Petr Nachtigal
BACKGROUND AND AIMS: Increased plasma levels of soluble endoglin (sEng) were detected in patients with endothelial dysfunction-related disorders and hypercholesterolemia. In this study, we hypothesized that high levels of sEng accompanied by mild hypercholesterolemia could aggravate endothelial and vessel wall dysfunction and affect endoglin/eNOS signaling in mouse aorta. METHODS: Three-month-old female transgenic mice on CBAxC57BL/6J background, with high levels of sEng (Sol-Eng+ high HFD), and their littermates with low levels of sEng (Sol-Eng+ low HFD), were fed a high fat diet for six months...
February 9, 2018: Atherosclerosis
https://www.readbyqxmd.com/read/29458993/longitudinal-association-of-metabolic-syndrome-and-dietary-patterns-a-13-year-prospective-population-based-cohort-study
#18
R Hassannejad, I Kazemi, M Sadeghi, N Mohammadifard, H Roohafza, N Sarrafzadegan, M Talaei, M Mansourian
BACKGROUND AND AIMS: Diet is a potential factor contributing to the development of the Metabolic Syndrome (MetS). This longitudinal study with repeated measurements of dietary intake was thus conducted to examine the longitudinal association between major dietary patterns and risk of MetS. METHODS AND RESULTS: The study was conducted within the framework of the Isfahan Cohort Study (ICS), in which 1387 participants were followed from 2001 to 2013. Validated food frequency questionnaire, anthropometric measurements, blood pressure, fasting serum lipids and blood sugars were evaluated in three phases of the study...
November 6, 2017: Nutrition, Metabolism, and Cardiovascular Diseases: NMCD
https://www.readbyqxmd.com/read/29458352/reducing-ghg-emissions-while-improving-diet-quality-exploring-the-potential-of-reduced-meat-cheese-and-alcoholic-and-soft-drinks-consumption-at-specific-moments-during-the-day
#19
Mirjam E van de Kamp, S Marije Seves, Elisabeth H M Temme
BACKGROUND: The typical Western diet is associated with high levels of greenhouse gas (GHG) emissions and with obesity and other diet-related diseases. This study aims to determine the impact of adjustments to the current diet at specific moments of food consumption, to lower GHG emissions and improve diet quality. METHODS: Food consumption in the Netherlands was assessed by two non-consecutive 24-h recalls for adults aged 19-69 years (n = 2102). GHG emission of food consumption was evaluated with the use of life cycle assessments...
February 20, 2018: BMC Public Health
https://www.readbyqxmd.com/read/29455575/exercise-counteracts-the-homeostatic-decrease-in-thermogenesis-caused-by-caloric-restriction-in-sheep
#20
John-Paul Fuller-Jackson, Iain J Clarke, Alexandra Rao, Belinda A Henry
Caloric restriction causes a homeostatic reduction in thermogenesis. We aimed to determine whether exercise could counteract this. We studied four groups of normal-weight ewes ( n = 5), including control sedentary fed ad libitum, exercise fed ad libitum (30 min/d, 5 d/wk), diet-restricted (70% of ad libitum food intake), and combined diet and exercise. Temperature probes implanted in sternal and retroperitoneal adipose tissue and skeletal muscle measured thermogenesis. After the 4-wk intervention, hypothalami were collected for in situ hybridization, and fat and muscle biopsies were collected for real-time PCR and Western blotting...
February 13, 2018: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
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