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https://www.readbyqxmd.com/read/29232772/s-nitrosohemoglobin-levels-and-patient-outcome-after-transfusion-during-pediatric-bypass-surgery
#1
Faisal Matto, Peter C Kouretas, Richard Smith, Jacob Ostrowsky, Anthony J Cina, Douglas T Hess, Jonathan S Stamler, James D Reynolds
Banked blood exhibits impairments in nitric oxide (NO)-based oxygen delivery capability, reflected in rapid depletion of S-nitrosohemoglobin (SNO-Hb). We hypothesized that transfusion of even freshly-stored blood used in pediatric heart surgery would reduce SNO-Hb levels and worsen outcome. In a retrospective review (n = 29), the percent of estimated blood volume (% eBV) replaced by transfusion directly correlated with ventilator time and inversely correlated with kidney function; similar results were obtained in a prospective arm (n = 20)...
December 12, 2017: Clinical and Translational Science
https://www.readbyqxmd.com/read/29232618/pediatric-medicolegal-autopsy-in-france-a-forensic-histopathological-approach
#2
Clémence Delteil, Lucile Tuchtan, Julia Torrents, Caroline Capuani, Marie-Dominique Piercecchi-Marti
The aim of postmortem medicolegal examination in pediatric death is primarily to establish the circumstances and causes of death and to exclude child abuse. In France, pediatric death is systematically documented by medicolegal or medical autopsy. In case of medicolegal autopsy, the complementary examinations, requested and financed by justice, are rarely limited to a histopathological examination. However in medical autopsies other tools are available to the pathologist as toxicology, biochemistry and molecular biology...
December 5, 2017: Journal of Forensic and Legal Medicine
https://www.readbyqxmd.com/read/29231856/involvement-of-udp-glucuronosyltransferases-and-sulfotransferases-in-the-excretion-and-tissue-distribution-of-resveratrol-in-mice
#3
Michaela Böhmdorfer, Akos Szakmary, Robert H Schiestl, Javier Vaquero, Juliane Riha, Stefan Brenner, Theresia Thalhammer, Thomas Szekeres, Walter Jäger
Resveratrol is a naturally occurring polyphenolic compound with various pharmacological activities. It is unknown whether the expression of metabolizing enzymes correlates with resveratrol levels in organs and tissues. Therefore, we investigated the metabolism and tissue distribution of resveratrol in mice and assessed its association with the expression of UDP-glucuronosyltransferase (Ugt) and sulfotransferase (Sult) genes. Plasma, urine, feces, and various organs were analyzed using high-performance liquid chromatography at up to 8 h after intragastric resveratrol administration...
December 12, 2017: Nutrients
https://www.readbyqxmd.com/read/29231439/-professor-lai-xinsheng-s-clinical-experience-in-the-treatment-of-premature-ovarian-failure-with-tongyuan-acupuncture-technique-and-chinese-herbal-medicine
#4
Xiaozhe Li, Sujuan Zhang
In the treatment of premature ovarian failure (POF), professor LAI Xinsheng focuses on the determination of syndrome to seek for etiology, associating with the differentiation of meridian and collateral and that of zangfu organs. Professor LAI believes that POF is mainly manifested as amenorrhea and infertility, localized in the kidney, with the dysfunction of liver, spleen and heart. It is impacted by many pathological factors, such as cold blockage, qi stagnation, blood stagnation, blood deficiency, yin deficiency, etc...
March 12, 2017: Zhongguo Zhen Jiu, Chinese Acupuncture & Moxibustion
https://www.readbyqxmd.com/read/29230685/calcitriol-reverses-the-down-regulation-pattern-of-tuberous-sclerosis-complex-genes-in-an-in-vitro-calcification-model
#5
Eraldo Fonseca Dos Santos Junior, Roberta Rodrigues de Lemos Gitirana, Darlene Paiva Bezerra, João Ricardo Mendes de Oliveira
Tuberous sclerosis complex (TSC) is a neurocutaneous syndrome with autosomal dominant inheritance, and most of the cases are related to loss of function of the TSC1 and TSC2 genes. TSC may occur with a wide range of clinical findings and skin, kidney, brain, and heart are the most commonly affected organs. Brain calcifications in TSC are also described and reported as diffuse and without pattern of symmetry or bilaterality. Recently, a new discovery opened the possibility of using vitamin D (VitD) for treating cerebral calcifications...
December 11, 2017: Journal of Molecular Neuroscience: MN
https://www.readbyqxmd.com/read/29230594/molecular-evolution-of-myoglobin-in-the-tibetan-plateau-endemic-schizothoracine-fish-cyprinidae-teleostei-and-tissue-specific-expression-changes-under-hypoxia
#6
Delin Qi, Yan Chao, Yongli Zhao, Mingzhe Xia, Rongrong Wu
Myoglobin (Mb) is an oxygen-binding hemoprotein that was once thought to be exclusively expressed in oxidative myocytes of skeletal and cardiac muscle where it serves in oxygen storage and facilitates intracellular oxygen diffusion. In this study, we cloned the coding sequence of the Mb gene from four species, representing three groups, of the schizothoracine fish endemic to the Qinghai-Tibetan Plateau (QTP), then conducted molecular evolution analyses. We also investigated tissue expression patterns of Mb and the expression response to moderate and severe hypoxia at the mRNA and protein levels in a representative of the highly specialized schizothoracine fish species, Schizopygopsis pylzovi...
December 11, 2017: Fish Physiology and Biochemistry
https://www.readbyqxmd.com/read/29230343/unusual-pathology-in-a-kidney-from-a-heart-transplant-patient
#7
Marie Larcher, Audey Delas, Clément Delmas, Olivier Cointault, Camille Dambrin, Arnaud Del Bello, Nassim Kamar
Acute kidney injury (AKI) is often observed after heart transplantation. In this setting, acute tubular necrosis is the main histological finding on kidneys. We report the unusual pathology found in a kidney from a heart-transplant patient. The patient experienced several hemodynamic insults, massive transfusion, and implantation of a mechanical circulatory-support device before heart transplantation: there was prolonged AKI after transplantation. A kidney biopsy revealed acute tubular necrosis and renal hemosiderosis, which was probably related to the transfusion and to mechanical circulatory-support device-induced intravascular hemolysis...
2017: Case Reports in Transplantation
https://www.readbyqxmd.com/read/29230325/a-study-on-knowledge-awareness-and-medication-adherence-in-patients-with-hypertension-from-a-tertiary-care-centre-from-northern-sri-lanka
#8
S Pirasath, T Kumanan, M Guruparan
Objective: To assess the patient's knowledge and awareness about hypertension and adherence to antihypertensive medication among hypertensive patients with validated Morisky questionnaires in a tertiary care centre of northern Sri Lanka. Methods: A cross-sectional descriptive comparative study was carried out at Teaching Hospital Jaffna, from January 2017 to April 2017. Hypertensive patients were recruited by systematic randomized controlled sampling and interviewed with validated Morisky questionnaires to assess their knowledge about hypertension...
2017: International Journal of Hypertension
https://www.readbyqxmd.com/read/29230260/-epidemiological-features-of-cardiorenal-syndrome-a-study-of-36-cases-in-the-cardiology-department-in-dakar
#9
Malick Bodian, Awa Thiaw, Simon Antoine Sarr, Kana Babaka, Fatou Aw, Aliou Alassane Ngaïde, Mouhamadou Bamba Ndiaye, Adama Kane, Modou Jobe, Alassane Mbaye, Maboury Diao, Moustapha Sarr, Serigne Abdou Ba
Introduction: Cardiorenal syndrome (CRS) is a pathophysiologic disorder of the heart and the kidneys whereby acute or chronic dysfunction in one organ may induce acute or chronic dysfunction of the other. In Africa, particularly in Senegal, the incidence of cardiorenal syndrome is not accurately known. This study aimed to assess the prevalence of CRS in the Cardiology Department. Methods: We conducted a retrospective study including all patients with heart failure associated with alteration of renal function, hospitalized in the Cardiology Department between April 2010 and April 2011...
2017: Pan African Medical Journal
https://www.readbyqxmd.com/read/29229756/decoding-the-molecular-switches-of-natriuretic-peptides-which-differentiate-its-vascular-and-renal-functions
#10
Sindhuja Sridharan, R Manjunatha Kini
Heart failure (HF) is associated with high morbidity and mortality. Dysfunction of blood pressure and/or volume homeostatic processes result in lower perfusion and/or congestion. Treatment strategies exerting differential effects on pressure and volume mechanisms are critical in handling patients with HF. Atrial natriuretic peptides (ANP) is a key hormone in maintaining circulation. It binds to NP receptor-A (NPR-A) on vasculature, kidneys and nervous system to lowers blood pressure and volume. It exerts a concentration-dependent pharmacological activity; only increased renal excretion of water and sodium at low doses and vasodilation along with renal effects at slightly higher doses...
December 11, 2017: Biochemical Journal
https://www.readbyqxmd.com/read/29229085/prevalence-of-comorbidities-in-copd-patients-by-disease-severity-in-a-german-population
#11
Timm Greulich, Benjamin J D Weist, Andreas Rembert Koczulla, Sabina Janciauskiene, Andreas Klemmer, Wolfram Lux, Peter Alter, Claus F Vogelmeier
Chronic obstructive pulmonary disease (COPD) is commonly associated with multiple comorbidities. Our objective was to assess the prevalence of comorbidities in patients with COPD and to relate their prevalence to the severity of the disease by using a large German health care database. Based on the retrospective analysis of a two-year (2013-2014) database from the German Statutory Health Insurance system, we obtained a representative sample of 4,075,493 german insurants. This sample included 146,141 patients with COPD (age: ≥35 years)...
November 2017: Respiratory Medicine
https://www.readbyqxmd.com/read/29228125/myeloid-neoplasms-following-solid-organ-transplantation-clinicopathologic-studies-of-23-cases
#12
Bin Wu, Kimberly Ingersoll, Rachel Jug, Lian-He Yang, Catherine Luedke, Amanda Lo, Pu Su, Xin Liu, Catherine Rehder, Jerald Gong, Chuanyi Mark Lu, Endi Wang
Objectives: Myeloid neoplasms (MNs) after solid organ transplant are rare, and their clinicopathologic features have not been well characterized. Methods: We retrospectively analyzed 23 such cases. Results: The ages ranged from 2 to 76 years, with a median of 59 years at the diagnosis. The median interval between the transplant and diagnosis was 56 months (range, 8-384 months). The transplanted organs included liver in five, kidney in six, lung in five, heart in six, and heart/lung in one case(s)...
December 7, 2017: American Journal of Clinical Pathology
https://www.readbyqxmd.com/read/29227952/public-health-risk-of-trace-metals-in-fresh-chicken-meat-products-on-the-food-markets-of-a-major-production-region-in-southern-china
#13
Yuanan Hu, Wenfeng Zhang, Gang Chen, Hefa Cheng, Shu Tao
Because most chickens are reared in intensive farms, where a range of feed additives are used routinely, concerns have been raised on the potential public health risk of chicken product consumption. This study was conducted to characterize the contents of trace metals in fresh chicken tissues (354 samples) on the food markets in Guangdong province of southern China, a major region of chicken production with heavy per capita chicken consumption, and to assess the public health risk from chronic dietary exposure to the trace metals through chicken consumption...
December 8, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/29226712/-risk-stratification-before-thoracic-surgery-perioperative-pulmonary-rehabilitation
#14
Attila Vágvölgyi, Zsolt Rozgonyi, Pál Vadász, János Tamás Varga
INTRODUCTION: Besides the oncology and operative surgical technics, functional aspects influence the operability of lung cancer. Preoperative risk stratification, evaluation of postoperative complications needs to be considered. AIM: To review international literature and experiences of our institute. METHOD: We focused the literature of risk stratification of thoracic surgery. Lung function, lung mechanics, chest kinematics, exercise physiology were considered...
December 2017: Orvosi Hetilap
https://www.readbyqxmd.com/read/29226427/case-report-treatment-of-light-chain-amyloidosis-with-daratumumab-monotherapy-in-two-patients
#15
Charlotte Gran, Gösta Gahrton, Evren Alici, Hareth Nahi
Immunoglobulin light-chain amyloidosis (AL) affects multiple organs, most prominently the kidney and the heart. Renal and cardiac impairment are both associated with poor prognosis.(1) Typical treatment regimens for AL include proteasome inhibitors, alkylating agents, and steroids as well as autologous stem cell transplantation (ASCT) for younger, fit patients. Complete response after treatment is associated with a better outcome and can be measured by free light chain (FLC) reduction.(2, 3) Monoclonal antibodies such as daratumumab (Dara, human IgG1 anti-CD38) have shown promising efficacy for the treatment of relapsed and refractory multiple myeloma...
December 11, 2017: European Journal of Haematology
https://www.readbyqxmd.com/read/29226384/the-impact-of-volume-overload-on-right-heart-function-in-end-stage-renal-disease-patients-on-hemodialysis
#16
Serkan Ünlü, Asife Şahinarslan, Gökhan Gökalp, Özden Seçkin, Selim Turgay Arınsoy, Nuri Bülent Boyacı, Atiye Çengel
PURPOSE: The aim of this study was to evaluate the impact of volume overload on echocardiographic parameters used for the assessment of the right ventricle (RV) and right atrium (RA), to determine volume-independent parameters and to noninvasively investigate the physio-mechanics of RV and RA by examining end-stage kidney patients before and after hemodialysis (HD). METHODS: The echocardiographic images were obtained from 67 patients (49.2 ± 17.3 years, 23 f) before and after HD...
December 11, 2017: Echocardiography
https://www.readbyqxmd.com/read/29225820/iron-therapy-in-heart-failure-patients-without-anaemia-possible-implications-for-chronic-kidney-disease-patients
#17
REVIEW
Jolanta Malyszko, Stefan D Anker
Iron deficiency anaemia is a global health problem that manifests as fatigue and poor physical endurance. Anaemia can be caused by dietary iron deficiency, blood loss or a combination of poor iron absorption and ineffective iron mobilization in patients with chronic disease. Nephrologists caring for patients with impaired renal function understand that iron treatment is necessary to provide adequate iron for erythropoiesis during the treatment of overt anaemia. However, a less well-understood health problem is iron deficiency, which creates symptoms that overlap with those of anaemia and often occurs in concert with chronic disease...
December 2017: Clinical Kidney Journal
https://www.readbyqxmd.com/read/29225804/angiotensinogen-as-a-biomarker-of-acute-kidney-injury
#18
REVIEW
Sheeba Habeeb Ba Aqeel, Alejandro Sanchez, Daniel Batlle
Early recognition of acute kidney injury (AKI) is critical to prevent its associated complications as well as its progression to long term adverse outcomes like chronic kidney disease. A growing body of evidence from both laboratory and clinical studies suggests that inflammation is a key factor contributing to the progression of AKI regardless of the initiating event. Biomarkers of inflammation are therefore of interest in the evaluation of AKI pathogenesis and prognosis. There is evidence that the renin angiotensin aldosterone system is activated in AKI, which leads to an increase in angiotensin II (Ang II) formation within the kidney...
December 2017: Clinical Kidney Journal
https://www.readbyqxmd.com/read/29224980/factors-responsible-for-the-post-slaughter-loss-of-carcass-and-offal-s-in-abattoirs-in-south-africa
#19
Ishmael Festus Jaja, Borden Mushonga, Ezekiel Green, Voster Muchenje
Global demand for food is surging upward due to the expansion of human population. Hence food production and supply need to double with little or no waste to meet this demand. Food loss at any point in the farm to fork chain inhibits the stability of food security at household and national level. A retrospective (AR) and a post mortem meat inspection (PMMI) study to identify major causes of offal and carcass condemnation was conducted in three abattoirs namely, Adeliade, Queenstown and East London abattoirs represented as AD, QT, and EL respectively...
December 7, 2017: Acta Tropica
https://www.readbyqxmd.com/read/29224095/sex-differences-in-muscle-wasting
#20
Lindsey J Anderson, Haiming Liu, Jose M Garcia
With aging and other muscle wasting diseases, men and women undergo similar pathological changes in skeletal muscle: increased inflammation, enhanced oxidative stress, mitochondrial dysfunction, satellite cell senescence, elevated apoptosis and proteasome activity, and suppressed protein synthesis and myocyte regeneration. Decreased food intake and physical activity also indirectly contribute to muscle wasting. Sex hormones also play important roles in maintaining skeletal muscle homeostasis. Testosterone is a potent anabolic factor promoting muscle protein synthesis and muscular regeneration...
2017: Advances in Experimental Medicine and Biology
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