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arsenic trioxide

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https://www.readbyqxmd.com/read/29684687/arsenic-trioxide-inhibits-proliferation-and-induced-apoptosis-of-leukemia-stem-cells-with-drug-resistance
#1
Chunxia Liu, Hulai Wei, Xiaojian Yao, Bei Liu, Yaming Xi, Li Zhao
Acute myeloid leukemia (AML) patients show high relapse rates and some develop conventional chemotherapy resistance. Leukemia Stem Cells (LSCs) are the main player for AML relapses and drug resistance. K562/ADM cell, a leukemia resistant cell subtype, was used as leukemia multidrug resistant model to explore drug resistance of leukemia cells. We found that CD34+ CD38- , CD34+ CD38- CD123+ , cell surface markers of LSCs were significantly high expressed in K562/ADM cell, not in K562 cell with less drug resistance; compared with LSCs from K562, multidrug resistance protein P-gp and BCRP expression were significantly higher in K562/ADM cell...
March 2, 2018: Leukemia Research
https://www.readbyqxmd.com/read/29684096/toxic-effects-of-arsenic-trioxide-on-echinococcus-granulosus-protoscoleces-through-ros-production-and-ca2-er-stress-dependent-apoptosis
#2
Jiajie Li, Guangyao Tang, Wenjuan Qin, Rentan Yang, Rongji Ma, Bin Ma, Jianfeng Wei, Hailong Lv, Yufeng Jiang
Cystic echinococcosis is a severe parasitic disease that commonly affects the liver and causes abscesses or rupture into the surrounding tissues, leading to multiple complications, such as shock, severe abdominal pain, and post-treatment abscess recurrence. Currently, there are no efficient measures to prevent these complications. We previously confirmed that arsenic trioxide (As2O3) exhibited in vitro cytotoxicity against Echinococcus granulosus protoscoleces. In the present study, we aimed to explore the mechanism of As2O3-induced E...
April 19, 2018: Acta Biochimica et Biophysica Sinica
https://www.readbyqxmd.com/read/29674067/arsenic-speciation-in-hair-and-nails-of-acute-promyelocytic-leukemia-apl-patients-undergoing-arsenic-trioxide-treatment
#3
Baowei Chen, Fenglin Cao, Xiufen Lu, Shengwen Shen, Jin Zhou, X Chris Le
Arsenic in hair and nails has been used to assess chronic exposure of humans to environmental arsenic. However, it remains to be seen whether it is appropriate to evaluate acute exposure to sub-lethal doses of arsenic typically used in therapeutics. In this study, hair, fingernail and toenail samples were collected from nine acute promyelocytic leukemia (APL) patients who were administered intravenously the daily dose of 10 mg arsenic trioxide (7.5 mg arsenic) for up to 54 days. These hair and nail samples were analyzed for arsenic species using high performance liquid chromatography separation and inductively coupled plasma mass spectrometry detection (HPLC-ICPMS)...
July 1, 2018: Talanta
https://www.readbyqxmd.com/read/29670967/investigation-of-hsa-as-a-biocompatible-coating-material-for-arsenic-trioxide-nanoparticles
#4
Maneka Hoonjan, Geetanjali Sachdeva, Sudeshna Chandra, Prashant S Kharkar, Niteshkumar Sahu, Purvi Bhatt
The anticancer properties of arsenic trioxide (As2O3) are accompanied by highly cytotoxic effects on normal cells. This necessitates developing modalities towards the targeted delivery of As2O3. Albumins, on account of their large structure and presence of several interacting groups, are ideal for encapsulating or carrying various drugs. In the present study, human serum albumin (HSA) was chosen as a coating agent to increase the biocompatibility of As2O3. An in situ chemical precipitation method was adopted for the synthesis of HSA-coated As2O3 nanoparticles (HSA-As2O3NPs) that were further characterized by Fourier-transform infrared spectroscopy (FT-IR), X-ray diffraction (XRD), ultraviolet-visible (UV-vis) spectroscopy, inductively coupled plasma atomic emission spectrometry (ICP-AES), zeta potential and transmission electron microscopy (TEM)...
April 19, 2018: Nanoscale
https://www.readbyqxmd.com/read/29662624/arsenic-trioxide-mediated-suppression-of-mir-182-5p-is-associated-with-potent-anti-oxidant-effects-through-up-regulation-of-sesn2
#5
Liang-Ting Lin, Shin-Yi Liu, Jyh-Der Leu, Chun-Yuan Chang, Shih-Hwa Chiou, Te-Chang Lee, Yi-Jang Lee
Arsenic trioxide (ATO) is a traditional Chinese medicine that can induce oxidative stress for treatment of cancer cells. However, ATO may generate anti-oxidative responses to compromise the cytotoxic effect, but the underlying mechanisms remain unclear. Here we found that ATO could inhibit miR-182-5p expression in patient-derived primary S1 glioblastoma (GBM) cells accompanied by up-regulation of Sestrin-2 ( SESN2 ) mRNA, a known anti-oxidant molecule. This phenomenon was also detected in a U87MG glioma cell line, human lung adenocarcinoma H1299 cell line and A549 cell line...
March 23, 2018: Oncotarget
https://www.readbyqxmd.com/read/29629493/double-sided-personality-effects-of-arsenic-trioxide-on-inflammation
#6
REVIEW
Juan Zhang, Yue Zhang, Weiyan Wang, Chunling Li, Zhiyi Zhang
In 1992, arsenic trioxide (As2 O3 , ATO) was demonstrated to be an effective therapeutic agent against acute promyelocytic leukemia (APL), rekindling attention to ATO applications in U.S. Food and Drug Administration clinical trials for the treatment of cancers, such as leukemia, lymphomas, and solid tumors. ATO is a potent chemotherapeutic drug that can also be used to treat other diseases, such as autoimmune diseases, because it affects multiple pathways including apoptosis induction, differentiation stimulation, and proliferation inhibition...
April 9, 2018: Inflammation
https://www.readbyqxmd.com/read/29621150/arsenic-cadmium-and-lead-exposure-and-immunologic-function-in-workers-in-taiwan
#7
Chin-Ching Wu, Fung-Chang Sung, Yi-Chun Chen
There has been growing concern over the impact of environmental exposure to heavy metals and other trace elements on immunologic functions. This study investigated men's arsenic (As), cadmium (Cd) and lead (Pb) contents in hair samples and their associations with immunological indicators, including white blood cell (WBC), lymphocyte and monocyte counts, and the immunoglobulin (Ig) levels including IgA, IgG and IgE. We recruited 133 men from one antimony trioxide manufacturing plant, two glass manufacturing plants and two plastics manufacturing plants...
April 5, 2018: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29617346/effective-delivery-of-arsenic-trioxide-to-hpv-positive-cervical-cancer-cells-using-optimised-liposomes-a-size-and-charge-study
#8
Anam Akhtar, Scarlet Xiaoyan Wang, Lucy Ghali, Celia Bell, Xuesong Wen
Despite the success of arsenic trioxide (ATO) in treating haematological malignancies, its potential to treat solid tumours has not been fully exploited, owing to its dose-limiting toxicity and poor pharmacokinetics. In order to overcome this hurdle, liposomal encapsulation of the drug with different surface charges (neutral, negative, and positive) and sizes (100, 200 and 400 nm) were synthesised and tested on human papilloma virus (HPV)-positive HeLa and HPV-negative HT-3 cervical cancer cell lines. Two epithelial cell lines-human keratinocytes (HK) and human colon cells (CRL-1790)-were used as controls...
April 4, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29616847/switching-from-all-trans-retinoic-acid-to-arsenic-trioxide-for-newly-diagnosed-acute-promyelocytic-leukemia
#9
Jun Imagawa
No abstract text is available yet for this article.
April 4, 2018: Leukemia & Lymphoma
https://www.readbyqxmd.com/read/29615003/role-of-cytarabine-in-paediatric-acute-promyelocytic-leukemia-treated-with-the-combination-of-all-trans-retinoic-acid-and-arsenic-trioxide-a-randomized-controlled-trial
#10
Li Zhang, Yao Zou, Yumei Chen, Ye Guo, Wenyu Yang, Xiaojuan Chen, Shuchun Wang, Xiaoming Liu, Min Ruan, Jiayuan Zhang, Tianfeng Liu, Fang Liu, Benquan Qi, Wenbin An, Yuanyuan Ren, Lixian Chang, Xiaofan Zhu
BACKGROUND: The combination of all-trans-retinoic acid (ATRA) and arsenic trioxide (ATO) has been suggested to be safe and effective for adult acute promyelocytic leukaemia (APL). As of 2010, the role of cytarabine (Ara-C) in APL was controversial. The aim of this study was to test the efficacy and safety of ATRA and ATO in paediatric APL patients. Also, we assessed whether Ara-C could be omitted in ATO and ATRA- based trials in children. METHODS: We performed a randomized controlled trial in paediatric APL patients (≤14 years of age) in our hospital from May 2010 to December 2016...
April 3, 2018: BMC Cancer
https://www.readbyqxmd.com/read/29610575/arsenic-trioxide-induces-apoptosis-and-the-formation-of-reactive-oxygen-species-in-rat-glioma-cells
#11
Yuanyuan Sun, Chen Wang, Ligang Wang, Zhibo Dai, Kongbin Yang
Background: Arsenic trioxide (As2 O3 ) has a dramatic therapeutic effect on acute promyelocytic leukemia (APL) patients. It can also cause apoptosis in various tumor cells. This study investigated whether As2 O3 has an antitumor effect on glioma and explored the underlying mechanism. Results: MTT and trypan blue assays showed that As2 O3 remarkably inhibited growth of C6 and 9 L glioma cells. Cell viability decreased in glioma cells to a greater extent than in normal glia cells...
2018: Cellular & Molecular Biology Letters
https://www.readbyqxmd.com/read/29596829/influence-of-apl-therapeutic-drugs-on-nuclear-pore-complex-density-and-integrity
#12
Anna Lång, Alexander Øye, Jens Eriksson, Alexander D Rowe, Emma Lång, Stig Ove Bøe
During cell division, a large number of nuclear proteins are released into the cytoplasm due to nuclear envelope breakdown. Timely nuclear import of these proteins following exit from mitosis is critical for establishment of the G1 nuclear environment. Dysregulation of post-mitotic nuclear import may affect the fate of newly divided stem or progenitor cells and may lead to cancer. Acute promyelocytic leukemia (APL) is a malignant disorder that involves a defect in blood cell differentiation at the promyelocytic stage...
March 26, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29593659/how-to-control-htlv-1-associated-diseases-preventing-de-novo-cellular-infection-using-antiviral-therapy
#13
Amandine Pasquier, Sandrine Alais, Loic Roux, Maria-Isabel Thoulouze, Karine Alvarez, Chloé Journo, Hélène Dutartre, Renaud Mahieux
Five to ten million individuals are infected by Human T-cell Leukemia Virus type 1 (HTLV-1). HTLV-1 is transmitted through prolonged breast-feeding, by sexual contacts and by transmission of infected T lymphocytes through blood transfusion. One to ten percent of infected carriers will develop a severe HTLV-1-associated disease: Adult-T-cell leukemia/lymphoma (ATLL), or a neurological disorder named Tropical Spastic Paraparesis/HTLV-1 Associated Myelopathy (TSP/HAM). In vivo , HTLV-1 is mostly detected in CD4+ T-cells, and to a lesser extent in CD8+ T cells and dendritic cells...
2018: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29581752/enhanced-antitumor-activity-of-combined-megestrol-acetate-and-arsenic-trioxide-treatment-in-liver-cancer-cells
#14
Yan Xia, Xianhao Liu, Beibei Liu, Xiaoshi Zhang, Geng Tian
Liver cancer is an aggressive malignancy with a very high fatality rate. Although megestrol acetate (MA) and arsenic trioxide (ATO) have shown an antitumor effect in liver cancer cells, the therapeutic benefits of MA or ATO alone in patients with liver cancer were limited. The aim of the present study was to elucidate whether the co-treatment of MA/ATO could enhance antitumor efficacy in liver cancer cell lines (Hep G2 and BEL 7402) and explore the underlying anti-cancer mechanisms. The cell viability, apoptotic response and expression levels of associated proteins were detected by Cell Counting Kit-8 assay, flow cytometry and western blotting, respectively...
April 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29579321/long-term-outcome-of-relapsed-acute-promyelocytic-leukemia-treated-with-oral-arsenic-trioxide-based-reinduction-and-maintenance-regimens-a-15-year-prospective-study
#15
Harinder Gill, Rita Yim, Harold K K Lee, Vivien Mak, Shek-Ying Lin, Bonnie Kho, Sze-Fai Yip, June S M Lau, Wah Li, Ho-Wan Ip, Yu-Yan Hwang, Thomas S Y Chan, Eric Tse, Wing-Yan Au, Cyrus R Kumana, Yok-Lam Kwong
BACKGROUND: For patients who have acute promyelocytic leukemia (APL) in second complete remission (CR2), optimal postremission strategies remain undefined. METHODS: The role of an oral arsenic trioxide (As2 O3 )-based regimen in the management of patients who had APL in CR2 was examined. RESULTS: Seventy-three patients with APL in first relapse (R1) were studied. Oral As2 O3 -based reinduction resulted uniformly in CR2, irrespective of previous As2 O3 exposure...
March 26, 2018: Cancer
https://www.readbyqxmd.com/read/29574283/vs-5584-as-a-pi3k-mtor-inhibitor-enhances-apoptotic-effects-of-subtoxic-dose-arsenic-trioxide-via-inhibition-of-nf-%C3%AE%C2%BAb-activity-in-b-cell-precursor-acute-lymphoblastic-leukemia
#16
Bahareh Toosi, Farhad Zaker, Fatemeh Alikarami, Ahmad Kazemi, Majid Teremmahi Ardestanii
Activation of the phosphoinositide 3-kinase (PI3K)/Akt/mTOR pathway as a survival signaling cascade is a prominent feature of cancers such as acute lymphoblastic leukemia (ALL). In patients with B-cell precursor-ALL (BCP-ALL), the high activity of the pathway correlates with the weak response to anti-leukemic drugs and relapse as a result of downstream prosurvival pathway activation, such as nuclear factor kappa B (NF-κB). Recent targeted therapy (PI3K/mTOR inhibitors) in combination with a multifunctional conventional chemotherapeutic drug may be useful for treatment of BCP-ALL patients...
March 22, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29569195/alterations-of-antioxidant-indexes-and-inflammatory-cytokine-expression-aggravated-hepatocellular-apoptosis-through-mitochondrial-and-death-receptor-dependent-pathways-in-gallus-gallus-exposed-to-arsenic-and-copper
#17
Juanjuan Liu, Hongjing Zhao, Yu Wang, Yizhi Shao, Jinglun Li, Mingwei Xing
In this study, we sought to investigate the effects of sub-chronic exposure of arsenic (As) and copper (Cu) on oxidative stress, inflammatory response, and mitochondria and death receptor apoptosis pathways in chicken liver. Seventy-two 1-day-old male Hy-line chickens were treated with basal diet, 30 mg/kg arsenic trioxide (As2 O3 ), or/and 300 mg/kg copper sulfate (CuSO4 ) for 4, 8, and 12 weeks. Study revealed that exposure to As or/and Cu undermined the antioxidant function and increased lipid peroxidation...
March 22, 2018: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29566848/corrigendum-to-comparison-of-induction-therapy-in-non-high-risk-acute-promyelocytic-leukemia-with-arsenic-trioxide-or-in-combination-with-atra-leukemia-research-66-2018-85-88
#18
Ardeshir Ghavamzadeh, Mahdi Jalili, Sharbanoo Rostami, Marjan Yaghmaie, Leyla Sharifi Aliabadi, Seyed Asadollah Mousavi, Mohammad Vaezi, Hossein Kamranzadeh Fumani, Mohammad Jahani, Kamran Alimoghaddam
No abstract text is available yet for this article.
April 2018: Leukemia Research
https://www.readbyqxmd.com/read/29554366/zyh005-a-novel-dna-intercalator-overcomes-all-trans-retinoic-acid-resistance-in-acute-promyelocytic-leukemia
#19
Qingyi Tong, Huijuan You, Xintao Chen, Kongchao Wang, Weiguang Sun, Yufeng Pei, Xiaodan Zhao, Ming Yuan, Hucheng Zhu, Zengwei Luo, Yonghui Zhang
Despite All-trans retinoic acid (ATRA) has transformed acute promyelocytic leukemia (APL) from the most fatal to the most curable hematological cancer, there remains a clinical challenge that many high-risk APL patients who fail to achieve a complete molecular remission or relapse and become resistant to ATRA. Herein, we report that 5-(4-methoxyphenethyl)-[1, 3] dioxolo [4, 5-j] phenanthridin-6(5H)-one (ZYH005) exhibits specific anticancer effects on APL and ATRA-resistant APL in vitro and vivo, while shows negligible cytotoxic effect on non-cancerous cell lines and peripheral blood mononuclear cells from healthy donors...
March 15, 2018: Nucleic Acids Research
https://www.readbyqxmd.com/read/29552182/accumulation-and-suppressive-function-of-regulatory-t-cells-in-malignant-ascites-reducing-their-suppressive-function-using-arsenic-trioxide-in-vitro
#20
Zilong Hu, Shidong Hu, Youjun Wu, Songyan Li, Changzheng He, Xiaowei Xing, Yufeng Wang, Xiaohui Du
Although adoptive cell therapy (ACT) has demonstrated effective and remarkable clinical responses in several studies, this approach does not lead to objective clinical responses in all cases. The function of ACT is often compromised by various tumor escape mechanisms, including the accumulation of immunoregulatory cells. As a result of peritoneal metastasis in the terminal stage, malignant ascites fluid lacks effectiveness and is a poor prognostic factor for gastric cancer. The present study assessed T-cell subsets in lymphocytes derived from malignant ascites, and investigated the effects of arsenic trioxide (As2 O3 ) on regulatory T cells (Tregs) and ascites-derived tumor-infiltrating lymphocytes (TILs) in vitro ...
April 2018: Oncology Letters
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