Wen Jin, Yu Sun, Jiaqi Wang, Yan Wang, Dan Chen, Ming Fang, Jie He, Linsheng Zhong, Hao Ren, Yuanmei Zhang, Hao Yin, Shijia Wu, Ruqin Chen, Wen Yan
Arsenic trioxide (ATO) is well known for its inhibitory effects on cancer progression, including lung adenocarcinoma (LUAD), but the molecular mechanism remains elusive. This study aimed to investigate the roles of ATO in regulating LUAD stem cells (LASCs) and the underlying mechanisms. To induce LASCs, cells cultured in an F12 medium, containing B27, epidermal growth factor, and basic fibroblast growth factor, induced LASCs. LASCs stemness was assessed through tumor sphere formation assay, and percentages of CD133+ cells were detected by flow cytometry...
2024: American Journal of Cancer Research