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arsenic trioxide

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https://www.readbyqxmd.com/read/29035754/regulation-of-autophagy-factors-by-oxidative-stress-and-cardiac-enzymes-imbalance-during-arsenic-or-and-copper-induced-cardiotoxicity-in-gallus-gallus
#1
Siwen Li, Hongjing Zhao, Yu Wang, Yizhi Shao, Bangyi Wang, Yulong Wang, Mingwei Xing
Basal autophagy has an indispensable role in the functioning and maintenance of cardiac geometry under physiological conditions. Recently, increasing evidence has demonstrated that arsenic (As)/copper (Cu) play important roles in the autophagy of the heart. The current study was to evaluate whether oxidative damage by As or/and Cu was correlated with autophagy through the phosphatidylinositol 3-kinase (PI3K)/protein kinase B (AKT)/mammalian target of rapamycin (mTOR) pathway in the heart of birds. Arsenic trioxide (30mg/kg) or/and cupric sulfate (300mg/kg) were administered in a basal diet to male Hy-line chickens (one-day-old) for 12 weeks...
October 13, 2017: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/29033137/the-global-problem-of-early-deaths-in-acute-promyelocytic-leukemia-a-strategy-to-decrease-induction-mortality-in-the-most-curable-leukemia
#2
REVIEW
A P Jillella, V K Kota
Acute promyelocytic leukemia (APL) is a hyper-acute illness and presents with profound cytopenias in most patients and disseminated intravascular coagulation (DIC). Excellent treatment options are now available with drugs such as all-trans retinoic acid (ATRA), arsenic trioxide (ATO), anthracyclines and cytarabine. The outcome in APL has improved tremendously in the last 50years due to better understanding of the disease, development of effective targeted agents and improvement in supportive care. Carefully selected groups of patients treated in large multi-center trials on a protocol and in experienced centers have shown survival rates in excess of 85%...
September 18, 2017: Blood Reviews
https://www.readbyqxmd.com/read/28980872/arsenic-trioxide-inhibits-cell-growth-and-motility-via-up-regulation-of-let-7a-in-breast-cancer-cells
#3
Ying Shi, Tong Cao, Hua Huang, Chaoqun Lian, Ying Yang, Zhiwei Wang, Jia Ma, Jun Xia
Arsenic trioxide (ATO) has been reported to exert its anti-cancer activities in human cancers. However, the molecular mechanism of ATO-triggered anti-tumor activity has not been fully elucidated. Recently, multiple studies demonstrated that ATO could regulate miRNAs in human cancers. Therefore, in this study, we investigated whether ATO regulated let-7a in breast cancer cells. We found that ATO upregulated let-7a level in breast cancer cells. We also found that up-regulation of let-7a inhibited cell growth and induced apoptosis and retarded cell migration and invasion...
October 5, 2017: Cell Cycle
https://www.readbyqxmd.com/read/28978827/current-treatment-strategies-for-newly-diagnosed-and-relapsed-apl
#4
Nobuhiko Emi
Acute promyelocytic leukemia (APL) is defined by its characteristic morphology (AML FAB M3/M3v), specific chromosomal translocation t (15;17), and molecular correlates (PML/RARα). Treatment with all-trans retinoic acid (ATRA) combined with chemotherapy has a high cure rate. Clinical trials with arsenic trioxide (ATO) confirmed the efficacy of ATO for patients with relapsed APL. Recently, treatment with ATRA and ATO has been shown to result in high CR rates for the majority of patients with newly diagnosed APL...
2017: [Rinshō Ketsueki] the Japanese Journal of Clinical Hematology
https://www.readbyqxmd.com/read/28978663/distinct-tp73-dapk2-atg5-pathway-involvement-in-ato-mediated-cell-death-versus-atra-mediated-autophagy-responses-in-apl
#5
Magali Humbert, Elena A Federzoni, Mario P Tschan
We have previously demonstrated that the death-associated protein kinase 2 (DAPK2) expression is significantly reduced in acute myeloid leukemia (AML), particularly in acute promyelocytic leukemia (APL) blast cells. In this study, we aimed at further understanding DAPK2 function and regulation during arsenic trioxide (ATO) cytotoxic or all-trans retinoic acid (ATRA) differentiation therapy in APL cells. We found that the p53 family member transactivation domain-p73 isoform (TAp73) binds to and activates the DAPK2 promoter, whereas the dominant-negative ΔNp73 isoform inhibits DAPK2 transcription...
October 4, 2017: Journal of Leukocyte Biology
https://www.readbyqxmd.com/read/28978146/eriodictyol-attenuates-arsenic-trioxide-induced-liver-injury-by-activation-of-nrf2
#6
Guanghong Xie, Xiaolin Meng, Fei Wang, Yuxin Bao, Junyuan Huo
Arsenic, a well-known human carcinogen, has been reported to induce hepatic oxidative stress and hepatic injury. Eriodictyol, a flavonoid found in citrus fruits, has been reported to have antioxidant effects. In this study, we aimed to investigate the protective effects of eriodictyol on arsenic trioxide (As2O3)-induced liver injury and to clarify the molecular mechanism. Male Wistar rats were administrated 3mg/kg As2O3 intravenous injection at days 1, 4, 5, and 7. Eriodictyol was given 1 h before or after As2O3 treatment...
September 15, 2017: Oncotarget
https://www.readbyqxmd.com/read/28967049/analysis-of-28-trace-elements-in-the-blood-and-serum-antioxidant-status-in-chickens-under-arsenic-and-or-copper-exposure
#7
Si-Wen Li, Yi-Zhi Shao, Hong-Jing Zhao, Yu Wang, Jing-Lun Li, Ming-Wei Xing
This study aimed to evaluate the 28 trace elements in the blood and serum antioxidant status in chickens under arsenic (As) and/or copper (Cu) exposure. A total of 200 1-day-old male Hy-Line chickens were fed either a commercial diet (C-group) or arsenic trioxide (30 mg/kg) and/or cupric sulfate (300 mg/kg) for 90 days. The 28 trace element levels in the blood were analyzed by inductively coupled plasma mass spectrometry (ICP-MS). The concentrations of As in the blood of chickens were elevated approximately 17...
October 1, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28966729/arsenic-trioxide-induces-apoptosis-via-specific-signaling-pathways-in-ht-29-colon-cancer-cells
#8
Jacqueline J Stevens, Barbara Graham, Erika Dugo, Bezawit Berhaneselassie-Sumner, Kenneth Ndebele, Paul B Tchounwou
BACKGROUND: Arsenic trioxide (ATO) is highly effective in the treatment of patients with acute promyelocytic leukemia (APL). It is a chemotherapeutic agent that has been shown to induce apoptosis in several tumor cell lines. However, research into its effects on colon carcinoma cells is still very limited. We previously reported that ATO is cytotoxic and causes DNA damage in HT-29 human colorectal adenocarcinoma cells. In the present study, we further evaluated its effect on oxidative stress (OS), and examined its apoptotic mechanisms of action on HT-29 cells...
January 2017: Journal of Cancer Science & Therapy
https://www.readbyqxmd.com/read/28963906/abo-identical-and-washed-blood-transfusions-as-candidate-strategies-to-reduce-early-mortality-in-acute-promyelocytic-leukemia
#9
Tanmay Sahai, Kelly Henrichs, Majed Refaai, Joanna M Heal, Scott A Kirkley, Amy E Schmidt, Jason H Mendler, Debra Masel, Jane Liesveld, Christopher Aquina, Neil Blumberg
BACKGROUND: Despite dramatically improved long term outcomes seen with all-trans retinoic acid therapy, and now arsenic trioxide, in acute promyelocytic leukemia (APL), early mortality remains a substantial challenge. Recent data from a single center study and the Surveillance, Epidemiology and End Results (SEER) registry report 30day mortality rates of 26% (n=18 of 70) and 17% (n=238 of 1400), respectively. Early deaths are predominately due to hemorrhage. Patients with APL invariably have abnormal laboratory hemostasis tests...
September 23, 2017: Leukemia Research
https://www.readbyqxmd.com/read/28961318/hoxa9-is-critical-in-the-proliferation-differentiation-and-malignancy-of-leukaemia-cells-both-in-vitro-and-in-vivo
#10
Shibing Chen, Juan Yu, Xin Lv, Lijuan Zhang
Progress in the understanding of the molecular mechanism for acute myeloid leukaemia is of great significance to generate new potential targets for treatment. Recent studies showed that HOXA9, a homeodomain-containing transcription factor, is commonly deregulated in acute leukaemia. In this study, we elucidated the direct correlation between HoxA9 expression and progression of leukaemia using 2 different types of leukaemia cells HL-60 and MOLT-3. The HoxA9 expression level was decreased in leukaemia cells with the treatment of all-trans retinoic acid or arsenic trioxide (As2 O3 )...
September 29, 2017: Cell Biochemistry and Function
https://www.readbyqxmd.com/read/28956719/arsenic-trioxide-exposure-impairs-testicular-morphology-in-adult-male-mice-and-consequent-fetus-viability
#11
Raquel Frenedoso da Silva, Cibele Dos Santos Borges, Celina de Almeida Lamas, Valéria Helena Alves Cagnon, Wilma de Grava Kempinas
The acute promyelocytic leukemia (APL) is a rare disease, affecting 0.1/100,000 individuals globally. Despite significant advances in APL therapy, some patients still experience relapsed disease. Currently, arsenic trioxide (As2O3) was found to be effective in relapsed APL treatment and considered as standard treatment for these cases. However, it has been shown that exposure to As2O3 may exert adverse effects on the male reproductive system since this substance might also induce apoptosis of other important cell types including stem cells...
September 28, 2017: Journal of Toxicology and Environmental Health. Part A
https://www.readbyqxmd.com/read/28940056/causes-and-prognostic-factors-for-early-death-in-patients-with-acute-promyelocytic-leukemia-treated-with-single-agent-arsenic-trioxide
#12
Jinxiao Hou, Shuye Wang, Yingmei Zhang, Dachuan Fan, Haitao Li, Yiju Yang, Fei Ge, Wenyi Hou, Jinyue Fu, Ping Wang, Hongli Zhao, Jiayue Sun, Kunpeng Yang, Jin Zhou, Xiaoxia Li
Early death (ED) is one of the most critical issues involved in the current care of patients with acute promyelocytic leukemia (APL). Factors identified as independent predictors of ED varied among published studies. We retrospectively analyzed the incidence, causes, and prognostic factors of ED in a series of 216 patients with newly diagnosed APL who received arsenic trioxide (ATO) as induction therapy. Multivariate logistic regression analysis was used to determine the association of clinical factors with overall ED, hemorrhagic ED, death within 7 days, and death within 8-30 days...
September 22, 2017: Annals of Hematology
https://www.readbyqxmd.com/read/28939896/mir-155-mediates-arsenic-trioxide-resistance-by-activating-nrf2-and-suppressing-apoptosis-in-lung-cancer-cells
#13
Shiyan Gu, Yanhao Lai, Hongyu Chen, Yuan Liu, Zunzhen Zhang
Arsenic trioxide (ATO) resistance is a challenging problem in chemotherapy. However, the underlying mechanisms remain to be elucidated. In this study, we identified a high level of expression of miR-155 in a human lung adenocarcinoma A549R cell line that is highly resistant to ATO. We showed that the high level of miR-155 was associated with increased levels of cell survival, colony formation, cell migration and decreased cellular apoptosis, and this was mediated by high levels of Nrf2, NAD(P)H quinone oxidoreductase 1 (NQO1), heme oxygenase-1 (HO-1) and a high ratio of Bcl-2/Bax...
September 22, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28934679/the-kinetics-of-white-blood-cell-and-the-predictive-factors-of-leukocytosis-under-oral-or-intravenous-arsenic-as-the-first-line-treatment-for-acute-promyelocytic-leukemia
#14
Fang Wang, Jin-Song Jia, Jing Wang, Ting Zhao, Qian Jiang, Hao Jiang, Hong-Hu Zhu
OBJECTIVE: We aimed to compare the kinetics of white blood cell (WBC) and explore predictive factors of leukocytosis in non-high-risk acute promyelocytic leukemia (APL), with oral arsenic plus all-trans retinoic acid (ATRA) or intravenous arsenic trioxide (ATO) plus ATRA as a first-line treatment. METHODS: The absolute count, doubling time and peak time of WBC were analyzed in 64 newly diagnosed non-high-risk APL patients who were treated with different induction regimens containing either oral Realgar-indigo naturalis formula (RIF) (n=35) or ATO (n=29)...
October 2017: Leukemia Research
https://www.readbyqxmd.com/read/28928847/anti-angiogenic-effect-of-arsenic-trioxide-in-lung-cancer-via-inhibition-of-endothelial-cell-migration-proliferation-and-tube-formation
#15
Meng-Hang Yang, Ke-Jie Chang, Jin-Cheng Zheng, Hai Huang, Guang-Yuan Sun, Xue-Wei Zhao, Bing Li, Qing-Yu Xiu
Arsenic trioxide (As2O3) exhibits a remarkable effect on leukemia treatment; however, its effect on solid tumors remains poorly explored. The present study demonstrated the inhibitory effect of As2O3 on lung cancer and explored its possible mechanism. It was observed that As2O3 significantly inhibited the growth of lung cancer xenografts and tumor angiogenesis in vivo. The inhibitory effect of As2O3 on cell proliferation in vitro was more remarkable in vascular endothelial cells than in lung cancer cells. It was also observed that As2O3 inhibited the migration of vascular endothelial cells and disrupted vascular tube formation on Matrigel assays...
September 2017: Oncology Letters
https://www.readbyqxmd.com/read/28927142/tumour-growth-suppressive-effect-of-arsenic-trioxide-in-squamous-cell-lung-carcinoma
#16
Leanne Lee Leung, Sze-Kwan Lam, Yuan-Yuan Li, James Chung-Man Ho
Lung squamous cell carcinoma (SCC) is the second most common subtype of non-small cell lung carcinoma. The anticancer effects of arsenic trioxide (ATO) in lung adenocarcinoma and small-cell lung cancer have previously been reported; however its effects in SCC remain unclear. An MTT assay and western blot analysis were performed to determine cell viability and protein expression, respectively, in the SK-MES-1 and SW900 SCC cell lines following treatment with ATO. Phosphatidylserine externalization, mitochondrial membrane depolarization and cell cycle distribution were studied using flow cytometry and the in vivo effects of ATO on tumour growth were investigated with a xenograft model...
September 2017: Oncology Letters
https://www.readbyqxmd.com/read/28927072/arsenic-trioxide-potentiates-sensitivity-of-multiple-myeloma-cells-to-lenalidomide-by-upregulating-cereblon-expression-levels
#17
Yuan Jian, Wen Gao, Chuanying Geng, Huixing Zhou, Yun Leng, Yanchen Li, Wenming Chen
The mechanism of the anti-myeloma effect of the immunomodulatory drug lenalidomide relies upon the binding of lenalidomide or an analogue to cereblon (CRBN) ubiquitin ligase, which inhibits it and results in the degradation of Ikaros-family zinc finger proteins 1 and 3 (IKZF1 and IKZF3). To determine whether the traditional Chinese medicine arsenic trioxide, could potentiate sensitivity of multiple myeloma (MM) cells to lenalidomide and identify the mechanism by which this happens, the present study investigated how arsenic trioxide affected CRBN on MM cell lines and examined the anti-myeloma effect and mechanism in the combination of arsenic trioxide and lenalidomide...
September 2017: Oncology Letters
https://www.readbyqxmd.com/read/28924550/establishment-and-characterization-of-arsenic-trioxide-resistant-kb-ato-cells
#18
Yun-Kai Zhang, Chunling Dai, Chun-Gang Yuan, Hsiang-Chun Wu, Zhijie Xiao, Zi-Ning Lei, Dong-Hua Yang, X Chris Le, Liwu Fu, Zhe-Sheng Chen
Arsenic trioxide (ATO) is used as a chemotherapeutic agent for the treatment of acute promyelocytic leukemia. However, increasing drug resistance is reducing its efficacy. Therefore, a better understanding of ATO resistance mechanism is required. In this study, we established an ATO-resistant human epidermoid carcinoma cell line, KB/ATO, from its parental KB-3-1 cells. In addition to ATO, KB/ATO cells also exhibited cross-resistance to other anticancer drugs such as cisplatin, antimony potassium tartrate, and 6-mercaptopurine...
September 2017: Acta Pharmaceutica Sinica. B
https://www.readbyqxmd.com/read/28914342/quantification-of-the-intracellular-life-time-of-water-molecules-to-measure-transport-rates-of-human-aquaglyceroporins
#19
Madelene Palmgren, Malin Hernebring, Stefanie Eriksson, Karin Elbing, Cecilia Geijer, Samo Lasič, Peter Dahl, Jesper S Hansen, Daniel Topgaard, Karin Lindkvist-Petersson
Orthodox aquaporins are transmembrane channel proteins that facilitate rapid diffusion of water, while aquaglyceroporins facilitate the diffusion of small uncharged molecules such as glycerol and arsenic trioxide. Aquaglyceroporins play important roles in human physiology, in particular for glycerol metabolism and arsenic detoxification. We have developed a unique system applying the strain of the yeast Pichia pastoris, where the endogenous aquaporins/aquaglyceroporins have been removed and human aquaglyceroporins AQP3, AQP7, and AQP9 are recombinantly expressed enabling comparative permeability measurements between the expressed proteins...
September 15, 2017: Journal of Membrane Biology
https://www.readbyqxmd.com/read/28912556/synthesis-and-in-vitro-anticancer-evaluation-of-polyarsenicals-related-to-the-marine-sponge-derived-arsenicin-a
#20
Ines Mancini, Matteo Planchestainer, Andrea Defant
In the light of the promising bioactivity of the tetraarsenic marine metabolite arsenicin A, the dimethyl analogue 2 and four isomeric methylene homologues (including the natural product itself) were obtained using a one-pot microwave-assisted synthesis, starting from arsenic (III) oxide. Due to the poor diagnostic value of the NMR technique in the structural elucidation of these molecules, they were fully characterized by mass spectrometry and infrared (IR)-spectroscopy, comparing density functional theory (DFT) simulated and experimental spectra...
September 14, 2017: Scientific Reports
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