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Monoamine oxidase, personality

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https://www.readbyqxmd.com/read/29186431/monoamine-oxidase-a-gene-methylation-and-its-role-in-posttraumatic-stress-disorder-first-evidence-from-the-south-eastern-europe-see-ptsd-study
#1
Christiane Ziegler, Christiane Wolf, Miriam A Schiele, Elma Feric Bojic, Sabina Kucukalic, Emina Sabic Dzananovic, Aferdita Goci Uka, Blerina Hoxha, Valdete Haxhibeqiri, Shpend Haxhibeqiri, Nermina Kravic, Mirnesa Muminovic Umihanic, Ana Cima Franc, Nenad Jaksic, Romana Babic, Marko Pavlovic, Bodo Warrings, Alma Bravo Mehmedbasic, Dusko Rudan, Branka Aukst-Margetic, Abdulah Kucukalic, Damir Marjanovic, Dragan Babic, Nada Bozina, Miro Jakovljevic, Osman Sinanovic, Esmina Avdibegovic, Ferid Agani, Alma Dzubur-Kulenovic, Jürgen Deckert, Katharina Domschke
Background: Posttraumatic Stress Disorder (PTSD) is characterized by an overactive noradrenergic system conferring core PTSD symptoms such as hyperarousal and re-experiencing. Monoamine oxidase A (MAO-A) is one of the key enzymes mediating the turnover of noradrenaline. Here, DNA methylation of the MAOA gene exonI/intronI region was investigated for the first time in regards to its role in PTSD risk and severity. Methods: MAOA methylation was analyzed via direct sequencing of sodium bisulfite treated DNA extracted from blood cells in a total sample of N=652 (m=441) patients with current PTSD, patients with remitted PTSD and healthy probands (comparison group) recruited at five centres in Bosnia-Herzegovina, Croatia, and the Republic of Kosovo...
November 23, 2017: International Journal of Neuropsychopharmacology
https://www.readbyqxmd.com/read/29075213/monoamine-oxidase-a-maoa-gene-and-personality-traits-from-late-adolescence-through-early-adulthood-a-latent-variable-investigation
#2
Man K Xu, Darya Gaysina, Roula Tsonaka, Alexandre J S Morin, Tim J Croudace, Jennifer H Barnett, Jeanine Houwing-Duistermaat, Marcus Richards, Peter B Jones
Very few molecular genetic studies of personality traits have used longitudinal phenotypic data, therefore molecular basis for developmental change and stability of personality remains to be explored. We examined the role of the monoamine oxidase A gene (MAOA) on extraversion and neuroticism from adolescence to adulthood, using modern latent variable methods. A sample of 1,160 male and 1,180 female participants with complete genotyping data was drawn from a British national birth cohort, the MRC National Survey of Health and Development (NSHD)...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/29073746/monoamine-oxidase-a-genetic-variants-and-childhood-abuse-predict-impulsiveness-in-borderline-personality-disorder
#3
Nathan J Kolla, Jeffrey Meyer, Marcos Sanches, James Charbonneau
Objective: Impulsivity is a core feature of borderline personality disorder (BPD) and antisocial personality disorder (ASPD) that likely arises from combined genetic and environmental influences. The interaction of the low activity variant of the monoamine oxidase-A (MAOA-L) gene and early childhood adversity has been shown to predict aggression in clinical and non-clinical populations. Although impulsivity is a risk factor for aggression in BPD and ASPD, little research has investigated potential gene-environment (G×E) influences impacting its expression in these conditions...
November 30, 2017: Clinical Psychopharmacology and Neuroscience: the Official Scientific Journal of the Korean College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/28851912/association-of-monoamine-oxidase-a-genetic-variants-and-amygdala-morphology-in-violent-offenders-with-antisocial-personality-disorder-and-high-psychopathic-traits
#4
Nathan J Kolla, Raihaan Patel, Jeffrey H Meyer, M Mallar Chakravarty
Violent offending is elevated among individuals with antisocial personality disorder (ASPD) and high psychopathic traits (PP). Morphological abnormalities of the amygdala and orbitofrontal cortex (OFC) are present in violent offenders, which may relate to the violence enacted by ASPD + PP. Among healthy males, monoamine oxidase-A (MAO-A) genetic variants linked to low in vitro transcription (MAOA-L) are associated with structural abnormalities of the amygdala and OFC. However, it is currently unknown whether amygdala and OFC morphology in ASPD relate to MAO-A genetic polymorphisms...
August 29, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28844162/the-association-of-measures-of-the-serotonin-system-personality-alcohol-use-and-smoking-with-risk-taking-traffic-behavior-in-adolescents-in-a-longitudinal-study
#5
Kadi Luht, Diva Eensoo, Liina-Mai Tooding, Jaanus Harro
Studies on the neurobiological basis of risk-taking behavior have most often focused on the serotonin system. The promoter region of the gene encoding the serotonin transporter contains a polymorphic site (5-HTTLPR) that is important for the transcriptional activity, and studies have demonstrated its association with brain activity and behavior. Another molecular mechanism that reflects the capacity of the central serotonin system is the activity of the enzyme monoamine oxidase (MAO) as measured in platelets...
August 26, 2017: Nordic Journal of Psychiatry
https://www.readbyqxmd.com/read/28802938/impulse-control-and-related-disorders-in-parkinson-s-disease
#6
Daniel Weintraub, Daniel O Claassen
Impulse control disorders (ICDs), such as compulsive gambling, buying, sexual, and eating behaviors, are a serious and increasingly recognized complication in Parkinson's disease (PD), occurring in up to 20% of PD patients over the course of their illness. Related behaviors include punding (stereotyped, repetitive, purposeless behaviors), dopamine dysregulation syndrome (DDS) (compulsive medication overuse), and hobbyism (e.g., compulsive internet use, artistic endeavors, and writing). These disorders have a significant impact on quality of life and function, strain interpersonal relationships, and worsen caregiver burden, and are associated with significant psychiatric comorbidity...
2017: International Review of Neurobiology
https://www.readbyqxmd.com/read/28273839/parkinson-s-disease-from-pathogenesis-to-pharmacogenomics
#7
REVIEW
Ramón Cacabelos
Parkinson's disease (PD) is the second most important age-related neurodegenerative disorder in developed societies, after Alzheimer's disease, with a prevalence ranging from 41 per 100,000 in the fourth decade of life to over 1900 per 100,000 in people over 80 years of age. As a movement disorder, the PD phenotype is characterized by rigidity, resting tremor, and bradykinesia. Parkinson's disease -related neurodegeneration is likely to occur several decades before the onset of the motor symptoms. Potential risk factors include environmental toxins, drugs, pesticides, brain microtrauma, focal cerebrovascular damage, and genomic defects...
March 4, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28119174/maoa-and-maob-polymorphisms-and-personality-traits-in-suicide-attempters-and-healthy-controls-a-preliminary-study
#8
Martina Balestri, Raffaella Calati, Alessandro Serretti, Annette M Hartmann, Bettina Konte, Marion Friedl, Ina Giegling, Dan Rujescu
Serotonergic neurotransmission dysfunctions have been well documented in patients with suicidal behaviour. We investigated monoamine oxidase A (MAOA: rs2064070, rs6323, rs909525) and B (MAOB: rs1799836, rs2311013, rs2205655) genetic modulation of personality traits (Temperament and Character Inventory, TCI) as endophenotype for suicidal behaviour. 108 suicide attempters and 286 healthy controls of German origin were screened. Among females, allelic analyses revealed associations between MAOA rs6323 A allele and higher Harm Avoidance in suicide attempters and MAOB rs2205655 A allele and higher Cooperativeness scores in healthy controls...
March 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28054193/personality-as-an-intermediate-phenotype-for-genetic-dissection-of-alcohol-use-disorder
#9
REVIEW
Lars Oreland, Gianvito Lagravinese, Simone Toffoletto, Kent W Nilsson, Jaanus Harro, C Robert Cloninger, Erika Comasco
Genetic and environmental interactive influences on predisposition to develop alcohol use disorder (AUD) account for the high heterogeneity among AUD patients and make research on the risk and resiliency factors complicated. Several attempts have been made to identify the genetic basis of AUD; however, only few genetic polymorphisms have consistently been associated with AUD. Intermediate phenotypes are expected to be in-between proxies of basic neuronal biological processes and nosological symptoms of AUD...
January 4, 2017: Journal of Neural Transmission
https://www.readbyqxmd.com/read/27903845/protein-biomarkers-of-mood-disorders
#10
REVIEW
Carmen Rodríguez Cerdeira, Elena Sánchez-Blanco, Beatriz Sánchez-Blanco, Jose Luis González-Cespón
Psychiatric evaluation presents a significant challenge because it conceptually integrates the input from multiple psychopathological approaches. Recent technological advances in the study of protein structure, function, and interactions have provided a breakthrough in the diagnosis and treatment of mood disorders (MD), and have identified novel biomarkers to be used as indicators of normal and disease states or response to drug treatment. The investigation of biomarkers for psychiatric disorders, such as enzymes (catechol-O-methyl transferase and monoamine oxidases) or neurotransmitters (dopamine, serotonin, norepinephrine) and their receptors, particularly their involvement in neuroendocrine activity, brain structure, and function, and response to psychotropic drugs, should facilitate the diagnosis of MD...
March 2017: International Journal of Immunopathology and Pharmacology
https://www.readbyqxmd.com/read/27333729/neurobiological-bases-of-alcohol-addiction
#11
REVIEW
Ana Matošić, Srđan Marušić, Branka Vidrih, Ana Kovak-Mufić, Lipa Cicin-Šain
Alcohol addiction is a heterogeneous psychiatric disorder according to both phenotype and etiology. Difference in phenotype characteristics manifests in the manner the addiction arises, history of the alcoholic and history of drinking, comorbid disorders, and the phenomenon of abstinence difficulties. Concerning the etiology of alcoholism, the disease itself is considered to be a consequence of an interactive influence of the environment and genetic factors. Numerous researches conducted in the last decades discovered many aspects of the biochemical, cell and molecular bases of alcohol addiction, leading to a conclusion that alcoholism is, like many other addictions, a brain disease...
March 2016: Acta Clinica Croatica
https://www.readbyqxmd.com/read/27190009/dopamine-d2-receptor-gene-variants-and-response-to-rasagiline-in-early-parkinson-s-disease-a-pharmacogenetic-study
#12
RANDOMIZED CONTROLLED TRIAL
Mario Masellis, Shannon Collinson, Natalie Freeman, Maria Tampakeras, Joseph Levy, Amir Tchelet, Eli Eyal, Elijahu Berkovich, Rom E Eliaz, Victor Abler, Iris Grossman, Cheryl Fitzer-Attas, Arun Tiwari, Michael R Hayden, James L Kennedy, Anthony E Lang, Jo Knight
The treatment of early Parkinson's disease with dopaminergic agents remains the mainstay of symptomatic therapy for this incurable neurodegenerative disorder. However, clinical responses to dopaminergic drugs vary substantially from person to person due to individual-, drug- and disease-related factors that may in part be genetically determined. Using clinical data and DNA samples ascertained through the largest placebo-controlled clinical trial of the monoamine oxidase B inhibitor, rasagiline (ClinicalTrials...
July 2016: Brain: a Journal of Neurology
https://www.readbyqxmd.com/read/26976063/ayahuasca-pharmacology-neuroscience-and-therapeutic-potential
#13
REVIEW
Elisabet Domínguez-Clavé, Joaquim Soler, Matilde Elices, Juan C Pascual, Enrique Álvarez, Mario de la Fuente Revenga, Pablo Friedlander, Amanda Feilding, Jordi Riba
Ayahuasca is the Quechua name for a tea obtained from the vine Banisteriopsis caapi, and used for ritual purposes by the indigenous populations of the Amazon. The use of a variation of the tea that combines B. caapi with the leaves of the shrub Psychotria viridis has experienced unprecedented expansion worldwide for its psychotropic properties. This preparation contains the psychedelic 5-HT2A receptor agonist N,N-dimethyltryptamine (DMT) from P. viridis, plus β-carboline alkaloids with monoamine-oxidase-inhibiting properties from B...
September 2016: Brain Research Bulletin
https://www.readbyqxmd.com/read/26964906/the-role-of-mao-in-personality-and-drug-use
#14
REVIEW
Jaanus Harro, Lars Oreland
Monoamine oxidases, both MAO-A and MAO-B, have been implicated in personality traits and complex behaviour, including drug use. Findings supporting the involvement of MAO-A and MAO-B in shaping personality and in the development of strategies of making behavioural choices come from a variety of studies that have examined either prevalence of gene variants in clinical groups or population-derived samples, estimates of enzyme activity in blood or, by positron emission tomography, in the brain and, most recently, measurement of methylation of the gene...
August 1, 2016: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/26908392/association-of-ventral-striatum-monoamine-oxidase-a-binding-and-functional-connectivity-in-antisocial-personality-disorder-with-high-impulsivity-a-positron-emission-tomography-and-functional-magnetic-resonance-imaging-study
#15
Nathan J Kolla, Katharine Dunlop, Jonathan Downar, Paul Links, R Michael Bagby, Alan A Wilson, Sylvain Houle, Fawn Rasquinha, Alexander I Simpson, Jeffrey H Meyer
Impulsivity is a core feature of antisocial personality disorder (ASPD) associated with abnormal brain function and neurochemical alterations. The ventral striatum (VS) is a key region of the neural circuitry mediating impulsive behavior, and low monoamine oxidase-A (MAO-A) level in the VS has shown a specific relationship to the impulsivity of ASPD. Because it is currently unknown whether phenotypic MAO-A markers can influence brain function in ASPD, we investigated VS MAO-A level and the functional connectivity (FC) of two seed regions, superior and inferior VS (VSs, VSi)...
April 2016: European Neuropsychopharmacology: the Journal of the European College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/26851573/monoamine-oxidase-and-agitation-in-psychiatric-patients
#16
Matea Nikolac Perkovic, Dubravka Svob Strac, Gordana Nedic Erjavec, Suzana Uzun, Josip Podobnik, Oliver Kozumplik, Suzana Vlatkovic, Nela Pivac
Subjects with schizophrenia or conduct disorder display a lifelong pattern of antisocial, aggressive and violent behavior and agitation. Monoamine oxidase (MAO) is an enzyme involved in the degradation of various monoamine neurotransmitters and neuromodulators and therefore has a role in various psychiatric and neurodegenerative disorders and pathological behaviors. Platelet MAO-B activity has been associated with psychopathy- and aggression-related personality traits, while variants of the MAOA and MAOB genes have been associated with diverse clinical phenotypes, including aggressiveness, antisocial problems and violent delinquency...
August 1, 2016: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/26494873/effects-of-the-maoa-gene-and-levels-of-exposure-to-violence-on-antisocial-outcomes
#17
Isabelle Ouellet-Morin, Sylvana M Côté, Frank Vitaro, Martine Hébert, René Carbonneau, Éric Lacourse, Gustavo Turecki, Richard E Tremblay
BACKGROUND: The monoamine oxidase A (MAOA) gene has been shown to moderate the impact of maltreatment on antisocial behaviour. Replication efforts have, however, yielded inconsistent results. AIMS: To investigate whether the interaction between the MAOA gene and violence is present across the full distribution of violence or emerges at higher levels of exposure. METHOD: Participants were 327 male members of the Québec Longitudinal Study of Kindergarten Children...
January 2016: British Journal of Psychiatry: the Journal of Mental Science
https://www.readbyqxmd.com/read/26165663/light-microscopy-can-reveal-the-consumption-of-a-mixture-of-psychotropic-plant-and-fungal-material-in-suspicious-death
#18
Patricia E J Wiltshire, David L Hawksworth, Kevin J Edwards
Light microscopical examination of plant and fungal remains in the post mortem gut may be capable of demonstrating the ingestion of unexpected natural psychotropic materials. This is demonstrated here in a case in which a 'shaman' was accused of causing the death of a young man. The deceased had participated in a ceremony which involved the drinking of ayahuasca in order to induce a psychotropic experience. Ayahuasca is an infusion of Banisteriopsis caapi (ayahuasca vine), which produces a monoamine oxidase inhibitor, and one or more additional tropical plants, generally Psychotria viridis (chacruna) which produces dimethyltryptamine (DMT)...
August 2015: Journal of Forensic and Legal Medicine
https://www.readbyqxmd.com/read/26087170/withdrawn-drugs-versus-placebo-for-dysthymia
#19
REVIEW
Mauricio Silva de Lima, Joanna Moncrieff, Bernardo G O Soares
No abstract text is available yet for this article.
2015: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/26081301/lower-monoamine-oxidase-a-total-distribution-volume-in-impulsive-and-violent-male-offenders-with-antisocial-personality-disorder-and-high-psychopathic-traits-an-11-c-harmine-positron-emission-tomography-study
#20
Nathan J Kolla, Brittany Matthews, Alan A Wilson, Sylvain Houle, R Michael Bagby, Paul Links, Alexander I Simpson, Amina Hussain, Jeffrey H Meyer
Antisocial personality disorder (ASPD) often presents with highly impulsive, violent behavior, and pathological changes in the orbitofrontal cortex (OFC) and ventral striatum (VS) are implicated. Several compelling reasons support a relationship between low monoamine oxidase-A (MAO-A), an enzyme that regulates neurotransmitters, and ASPD. These include MAO-A knockout models in rodents evidencing impulsive aggression and positron emission tomography (PET) studies of healthy subjects reporting associations between low brain MAO-A levels and greater impulsivity or aggression...
October 2015: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
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