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https://www.readbyqxmd.com/read/28342878/3d-printing-for-the-design-and-fabrication-of-polymer-based-gradient-scaffolds
#1
Laura G Bracaglia, Brandon T Smith, Emma Watson, Navein Arumugasaamy, Antonios G Mikos, John P Fisher
To accurately mimic the native tissue environment, tissue engineered scaffolds often need to have a highly controlled and varied display of three-dimensional (3D) architecture and geometrical cues. Additive manufacturing in tissue engineering has made possible the development of complex scaffolds that mimic the native tissue architectures. As such, architectural details that were previously unattainable or irreproducible can now be incorporated in an ordered and organized approach, further advancing the structural and chemical cues delivered to cells interacting with the scaffold...
March 22, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28330448/ascending-cholangitis-secondary-to-migrated-embolization-coil-of-gastroduodenal-artery-pseudo-aneurysm-a-case-report
#2
Haithem Zaafouri, Anis Hasnaoui, Sonia Essghaeir, Dhafer Haddad, Meriam Sabbah, Ahmed Bouhafa, Jamel Kharrat, Anis Ben Maamer
BACKGROUND: Gastroduodenalartery (GDA) pseudo-aneurysms are very rare. Their clinical importance lies in the eventuality of rupture, causing bleeding and ultimately exsanguination. CASE PRESENTATION: We report the case of a man, with prior history of biliary surgery, presenting with haemobilia secondary to a rupture of GDA pseudo-aneurysm eroding the main bile duct. The patient was treated with coil embolization. This technique is considered to be safe. However, on the long term, some complications may occur...
March 23, 2017: BMC Surgery
https://www.readbyqxmd.com/read/28329062/comparison-of-demographic-and-photobiological-features-of-chronic-actinic-dermatitis-in-patients-with-lighter-vs-darker-skin-types
#3
Ki-Wei Tan, Ann K Haylett, Tsui C Ling, Lesley E Rhodes
Importance: Chronic actinic dermatitis (CAD) is classically described in older, white men, although increasing reports describe younger patients with darker skin types, particularly South Asians. Photocontact allergy occurs in CAD but is less studied than contact allergy in this exquisitely photosensitive condition. Objective: To evaluate for differences in demographic and photobiological features between persons with darker and lighter skin types who have CAD. Design, Setting, and Participants: This retrospective review included 70 consecutive adult patients (≥18 years) undergoing investigation for photosensitivity who were diagnosed with CAD from November 1, 2000, through August 31, 2015, at the specialist Photobiology Unit of a tertiary academic referral center...
March 22, 2017: JAMA Dermatology
https://www.readbyqxmd.com/read/28322060/malnutrition-or-frailty-overlap-and-evidence-gaps-in-the-diagnosis-and-treatment-of-frailty-and-malnutrition
#4
Celia V Laur, Tara McNicholl, Renata Valaitis, Heather H Keller
There is increasing awareness of the detrimental health impact of frailty on older adults and of the high prevalence of malnutrition in this segment of the population. Experts in these 2 arenas need to be cognizant of the overlap in constructs, diagnosis, and treatment of frailty and malnutrition. There is a lack of consensus regarding the definition of malnutrition and how it should be assessed. While there is consensus on the definition of frailty, there is no agreement on how it should be measured. Separate assessment tools exist for both malnutrition and frailty; however, there is intersection between concepts and measures...
March 21, 2017: Applied Physiology, Nutrition, and Metabolism, Physiologie Appliquée, Nutrition et Métabolisme
https://www.readbyqxmd.com/read/28318131/hydrologic-refugia-plants-and-climate-change
#5
REVIEW
Blair C McLaughlin, David D Ackerly, P Zion Klos, Jennifer Natali, Todd E Dawson, Sally E Thompson
Climate, physical landscapes, and biota interact to generate heterogeneous hydrologic conditions in space and over time, which are reflected in spatial patterns of species distributions. As these species distributions respond to rapid climate change, microrefugia may support local species persistence in the face of deteriorating climatic suitability. Recent focus on temperature as a determinant of microrefugia insufficiently accounts for the importance of hydrologic processes and changing water availability with changing climate...
March 20, 2017: Global Change Biology
https://www.readbyqxmd.com/read/28316848/strongyloides-hyperinfection-in-a-renal-transplant-patient-always-be-on-the-lookout
#6
Murtaza Mazhar, Ijlal Akbar Ali, Nelson Iván Agudelo Higuita
We present a case of a 71-year-old Vietnamese man with chronic kidney disease secondary to adult polycystic kidney disease. He had been a prisoner of war before undergoing a successful cadaveric renal transplant in the United States. He presented to clinic one year after the transplant with gross hematuria, productive cough, intermittent chills, and weight loss. Long standing peripheral eosinophilia of 600-1200/μL triggered further evaluation. A wet mount of stool revealed Strongyloides stercoralis larvae...
2017: Case Reports in Infectious Diseases
https://www.readbyqxmd.com/read/28314450/conceptualization-of-success-in-young-adulthood
#7
REVIEW
Maryland Pao
Successful transition from childhood to adulthood is context and culture dependent. This article reviews concepts of mental health and theoretic constructs of successful adulthood that suggest intentional policies and practices are developed with a specific vision of success. Parents, educators, mental health professionals, and policymakers need to be cognizant of their assumptions and essential roles in these processes. The early development of illness may disrupt and alter the timelines of different developmental milestones and trajectories...
April 2017: Child and Adolescent Psychiatric Clinics of North America
https://www.readbyqxmd.com/read/28300862/reversible-posterior-leukoencephalopathy-syndrome-rpls-in-a-psoriasis-patient-treated-with-ustekinumab
#8
Lauren Dickson, Alan Menter
The use of monoclonal antibodies against interleukin (IL)-12 and -23, such as ustekinumab, has considerably reduced the disease burden in many patients with moderate to severe psoriasis. Reversible posterior leukoencephalopathy syndrome (RPLS) is a neurologic disorder that has been documented with increased frequency with the use of systemic and biologic agents. We report a case of a 58-year-old man with psoriasis who presented with confusion and memory difficulties after being on treatment with ustekinumab for over six years...
February 1, 2017: Journal of Drugs in Dermatology: JDD
https://www.readbyqxmd.com/read/28300860/annular-elastolytic-giant-cell-granuloma-successfully-treated-with-adalimumab-subsequently-complicated-by-drug-induced-lupus
#9
Adele Haimovic, Hideko Kamino, David E Cohen
We report a 51-year-old female with a 3-year history of recalcitrant annular elastolytic giant cell granuloma (AEGCG) who was effectively treated with the anti-tumor necrosis factor (TNF)-alpha antibody, adalimumab. Her disease was refractory to topical glucocorticoids, intralesional glucocorticoids, narrow-band ultraviolet light (UV)-B phototherapy and cyclosporine. During her treatment with adalimumab she developed a positive anti-nuclear-antibody and double-stranded-DNA antibody and her treatment was terminated...
February 1, 2017: Journal of Drugs in Dermatology: JDD
https://www.readbyqxmd.com/read/28299797/processes-that-inform-multicultural-supervision-a-meta-analysis
#10
Nilou B Tohidian, Karen Mui-Teng Quek
As the fields of counseling and psychotherapy have become more cognizant that individuals, couples, and families bring with them a myriad of diversity factors into therapy, multicultural competency has also become a crucial component in the development of clinicians during clinical supervision and training. We employed a qualitative meta-analysis to provide a detailed and comprehensive description of similar themes identified in primary qualitative studies that have investigated supervisory practices with an emphasis on diversity...
March 16, 2017: Journal of Marital and Family Therapy
https://www.readbyqxmd.com/read/28289269/epidemiological-investigation-of-parasitic-infection-of-schoolchildren-from-six-elementary-schools-in-sakon-nakhon-province-thailand
#11
Ryuichi Doi, Makoto Itoh, Somchai Chakhatrakan, Shoji Uga
We conducted an epidemiological study of intestinal parasitic infection in 572 schoolchildren aged 4 to 12 years old from six elementary schools in Sakon Nakhon Province, Thailand from June 2013 to August 2014. We collected fecal, blood, and urine samples to investigate parasitic infection and conducted a questionnaire survey. Soil samples were examined for egg contamination. Fecal examination, using the formalin-ether sedimentation method, revealed that 39% of schoolchildren were infected with eight genera and eight species of parasites; three nematodes, two trematodes, one cestode, and two protozoa...
February 15, 2017: Kobe Journal of Medical Sciences
https://www.readbyqxmd.com/read/28264207/hemostatic-resuscitation-in-peripartum-hysterectomy-pre-and-postmassive-transfusion-protocol-initiation
#12
Eryn H Dutta, Aaron T Poole, Faranak Behnia, Holly E Dunn, Shannon M Clark, Luis D Pacheco, George R Saade, Gary D V Hankins
Background Massive transfusion protocols (MTPs) have been examined in trauma. The exact ratio of packed red blood cells (PRBC) to other blood replacement components in hemostatic resuscitation in obstetrics has not been well defined. Objective The objective of this study was to evaluate hemostatic resuscitation in peripartum hysterectomy comparing pre- and postinstitution of a MTP. Study Design We conducted a retrospective, descriptive study of women undergoing peripartum hysterectomies from January 2002 to January 2015 who received ≥ 4 units of PRBC...
March 6, 2017: American Journal of Perinatology
https://www.readbyqxmd.com/read/28264090/comparison-of-male-vs-female-resident-milestone-evaluations-by-faculty-during-emergency-medicine-residency-training
#13
Arjun Dayal, Daniel M O'Connor, Usama Qadri, Vineet M Arora
Importance: Although implicit bias in medical training has long been suspected, it has been difficult to study using objective measures, and the influence of sex and gender in the evaluation of medical trainees is unknown. The emergency medicine (EM) milestones provide a standardized framework for longitudinal resident assessment, allowing for analysis of resident performance across all years and programs at a scope and level of detail never previously possible. Objective: To compare faculty-observed training milestone attainment of male vs female residency training...
March 6, 2017: JAMA Internal Medicine
https://www.readbyqxmd.com/read/28256481/spectrum-and-outcome-of-neonatal-emergencies-seen-in-a-free-health-care-program-in-south-western-nigeria
#14
M T Abiodun, R O Oluwafemi
BACKGROUND: Neonatal emergencies contribute significantly to under-five morbidity and mortality in developing countries, partly due to poverty and limited access to quality healthcare in rural communities. AIMS: The aim is to evaluate the spectrum, outcome, case fatality rates (CFRs), and prognostic factors of neonatal emergencies seen in the two free health-care facilities in Ondo State. METHODS: This was a cross-sectional descriptive study of neonatal emergencies...
March 2017: Nigerian Journal of Clinical Practice
https://www.readbyqxmd.com/read/28253058/the-comparison-of-instrument-assisted-soft-tissue-mobilization-and-self-stretch-measures-to-increase-shoulder-range-of-motion-in-overhead-athletes-a-critically-appraised-topic
#15
Matthew J Hussey, Alex E Boron-Magulik, Tamara C Valovich-McLeod, Cailee E Welch Bacon
Shoulder range of motion (ROM) in throwing athletes relies on a balance of mobility and stability in order to maintain proper function and health. Prior research has reported that deficits in internal rotation greater than 20 degrees, decreases in total arc of motion greater than 5 degrees when compared to the contralateral side, and decreases in horizontal adduction greater than 16 degrees have all been identified as factors that could lead to throwing related injuries.(1) Due to the increased risk of injury associated with ROM deficits, it is important for clinicians to be cognizant of how to most effectively treat these issues...
March 2, 2017: Journal of Sport Rehabilitation
https://www.readbyqxmd.com/read/28245882/development-of-a-surrogate-potency-assay-to-determine-the-angiogenic-activity-of-stempeucel%C3%A2-a-pooled-ex-vivo-expanded-allogeneic-human-bone-marrow-mesenchymal-stromal-cell-product
#16
Charan Thej, Balamurugan Ramadasse, Ankita Walvekar, Anish S Majumdar, Sudha Balasubramanian
BACKGROUND: Mesenchymal stromal cells (MSCs) have emerged as a more beneficial alternative to conventional therapy and may offer a potential cure for unmet medical needs. MSCs are known to possess strong immunomodulatory and anti-inflammatory properties. Moreover, they promote angiogenesis and tissue regeneration through the secretion of trophic factors. For these reasons, the past decade witnessed a sharp increase in the number of clinical trials conducted with stem cells for various vascular diseases requiring angiogenesis...
February 28, 2017: Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/28240929/self-relevance-prioritizes-access-to-visual-awareness
#17
C Neil Macrae, Aleksandar Visokomogilski, Marius Golubickis, William A Cunningham, Arash Sahraie
As we are cognizant of only a fraction of the available visual inputs at any given time, how is information selected for access to consciousness? In particular, does the personal significance of stimuli influence perceptual selection? Given that self-relevant information is prioritized during various stages of processing, here we hypothesized that self-association may privilege access to awareness under continuous flash suppression (CFS). The results supported this prediction. Compared with geometric shapes referenced to either a friend or stranger, those previously associated with self were prioritized in visual awareness...
March 2017: Journal of Experimental Psychology. Human Perception and Performance
https://www.readbyqxmd.com/read/28239208/exploring-the-dimensionality-of-morphological-knowledge-for-adolescent-readers
#18
Amanda P Goodwin, Yaacov Petscher, Joanne F Carlisle, Alison M Mitchell
This study examined the dimensionality of morphological knowledge. The performance of 371 seventh- and eighth-graders on seven morphological knowledge tasks was investigated using confirmatory factor analysis. Results suggested that morphological knowledge was best fit by a bifactor model with a general factor of morphological knowledge and seven specific factors, representing tasks that tap different facets of morphological knowledge. Next, structural equation modelling was used to explore links to literacy outcomes...
February 2017: Journal of Research in Reading
https://www.readbyqxmd.com/read/28231373/auricular-complications-in-parotid-temporal-bone-infratemporal-fossa-and-lateral-skull-base-surgery
#19
Patrick S Carpenter, Ryan C Burgette, John P Leonetti, Sam J Marzo
Neoplasms located in the parotid region, temporal bone, infratemporal fossa, and lateral skull base represent a challenge due to their difficult anatomic location and surrounding neurovascular structures. A variety of surgical approaches are appropriate to access this area, although several of them can place the auricular blood supply in danger. If the auricular blood supply is compromised, ischemia and, eventually, avascular necrosis of the auricle can occur. Auricular necrosis often can cause patients a delay in adjuvant radiation therapy and result in the need for additional reconstructive procedures...
February 2017: Ear, Nose, & Throat Journal
https://www.readbyqxmd.com/read/28225767/interferon-%C3%AE-1a-for-the-treatment-of-ebola-virus-disease-a-historically-controlled-single-arm-proof-of-concept-trial
#20
Mandy Kader Konde, Darren P Baker, Fode Amara Traore, Mamadou Saliou Sow, Alioune Camara, Alpha Amadou Barry, Doussou Mara, Abdoulaye Barry, Moussa Cone, Ibrahima Kaba, Amento Ablam Richard, Abdoul Habib Beavogui, Stephan Günther, Melania Pintilie, Eleanor N Fish
To date there are no approved antiviral drugs for the treatment of Ebola virus disease (EVD). Based on our in vitro evidence of antiviral activity of interferon (IFN)-ß activity against Ebola virus, we conducted a single arm clinical study in Guinea to evaluate the safety and therapeutic efficacy of IFN β-1a treatment for EVD. Nine individuals infected with Ebola virus were treated with IFN β-1a and compared retrospectively with a matched cohort of 21 infected patients receiving standardized supportive care only during the same time period at the same treatment unit...
2017: PloS One
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