keyword
MENU ▼
Read by QxMD icon Read
search

Branched-chain

keyword
https://www.readbyqxmd.com/read/27913948/branched-chain-amino-acids-administration-suppresses-endurance-exercise-related-activation-of-ubiquitin-proteasome-signaling-in-trained-human-skeletal-muscle
#1
Evgeny A Lysenko, Tatiana F Vepkhvadze, Egor M Lednev, Olga L Vinogradova, Daniil V Popov
We tested whether post exercise ingestion of branched-chain amino acids (BCAA < 10 g) is sufficient to activate signaling associated with muscle protein synthesis and suppress exercise-induced activation of mechanisms associated with proteolysis in endurance-trained human skeletal muscle. Nine endurance-trained athletes performed a cycling bout with and without BCAA ingestion (0.1 g/kg). Post exercise ACC(Ser79/222) phosphorylation (endogenous marker of AMPK activity) was increased (~3-fold, P < 0...
December 3, 2016: Journal of Physiological Sciences: JPS
https://www.readbyqxmd.com/read/27912058/impaired-amino-acid-transport-at-the-blood-brain-barrier-is-a-cause-of-autism-spectrum-disorder
#2
Dora C Tărlungeanu, Elena Deliu, Christoph P Dotter, Majdi Kara, Philipp Christoph Janiesch, Mariafrancesca Scalise, Michele Galluccio, Mateja Tesulov, Emanuela Morelli, Fatma Mujgan Sonmez, Kaya Bilguvar, Ryuichi Ohgaki, Yoshikatsu Kanai, Anide Johansen, Seham Esharif, Tawfeg Ben-Omran, Meral Topcu, Avner Schlessinger, Cesare Indiveri, Kent E Duncan, Ahmet Okay Caglayan, Murat Gunel, Joseph G Gleeson, Gaia Novarino
Autism spectrum disorders (ASD) are a group of genetic disorders often overlapping with other neurological conditions. We previously described abnormalities in the branched-chain amino acid (BCAA) catabolic pathway as a cause of ASD. Here, we show that the solute carrier transporter 7a5 (SLC7A5), a large neutral amino acid transporter localized at the blood brain barrier (BBB), has an essential role in maintaining normal levels of brain BCAAs. In mice, deletion of Slc7a5 from the endothelial cells of the BBB leads to atypical brain amino acid profile, abnormal mRNA translation, and severe neurological abnormalities...
December 1, 2016: Cell
https://www.readbyqxmd.com/read/27908546/effects-of-branched-chain-amino-acid-supplementation-after-radiofrequency-ablation-for-hepatocellular-carcinoma-a-randomized-trial
#3
Shunsuke Nojiri, Kei Fujiwara, Noboru Shinkai, Etsuko Iio, Takashi Joh
OBJECTIVE: Maintenance of liver function is important for better outcomes after radiofrequency ablation (RFA) for hepatocellular carcinoma (HCC). The aim of this study was to examine the effects of oral branched-chain amino acid (BCAA) supplementation on liver function, intrahepatic recurrence rate, and incidence of complications after RFA for HCC. METHODS: Patients with cirrhosis who underwent RFA were enrolled between August 2009 and April 2012, randomized to oral supplementation with Aminoleban EN (BCAA group) or diet alone (control group), and followed to determine changes in serum parameters and health status...
January 2017: Nutrition
https://www.readbyqxmd.com/read/27903517/branched-chain-fatty-acid-composition-of-human-milk-and-the-impact-of-maternal-diet-the-global-exploration-of-human-milk-gehm-study
#4
Kelly A Dingess, Christina J Valentine, Nicholas J Ollberding, Barbara S Davidson, Jessica G Woo, Suzanne Summer, Yongmei M Peng, M Lourdes Guerrero, Guillermo M Ruiz-Palacios, Rinat R Ran-Ressler, Robert J McMahon, J Thomas Brenna, Ardythe L Morrow
BACKGROUND: An understudied component of the diet, branched-chain fatty acids (BCFAs) are distinctive saturated fatty acids that may have an important influence on health. Human-milk fatty acid composition is known to differ worldwide, but comparative data are lacking on BCFAs. OBJECTIVE: We tested the hypotheses that concentrations of BCFAs in human milk differ between populations and are associated with maternal diet. DESIGN: We surveyed the BCFA composition of samples collected as part of a standardized, prospective study of human-milk composition...
November 30, 2016: American Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/27902233/promicromonospora-kermanensis-sp-nov-a-new-actinobacterium-isolated-from-soil
#5
Fatemeh Mohammadipanah, Maria Del Carmen Montero-Calasanz, Peter Schumann, Cathrin Spröer, Hans-Peter Klenk, Manfred Rohde
A novel Promicromonospora strain, designated HM 533T, was isolated from soil in Kerman Province, Iran. It produced long and branched hyphae on ISP 2 medium that developed into a large number of irregular shaped spores. It showed optimal growth at 25-30 °C and pH 5.0-8.0 with 0-4% (w/v) NaCl. The peptidoglycan type of strain HM 533T is A4α L-Lys - L-Ala - D-Glu. Whole cell hydrolyzates of strain HM 533T contained the sugars ribose, glucose and galactose. The main phospholipids were phosphatidylglycerol, diphosphatidylglycerol, phosphatidylinositol, two unknown glycolipids and an unknown phospholipid...
November 8, 2016: International Journal of Systematic and Evolutionary Microbiology
https://www.readbyqxmd.com/read/27900834/transformation-of-free-and-dipeptide-bound-glycated-amino-acids-by-two-strains-of-saccharomyces-cerevisiae
#6
Michael Hellwig, Marie Börner, Falco Beer, Karl-Heinz van Pée, Thomas Henle
The yeast Saccharomyces cerevisiae transforms branched-chain and aromatic amino acids to higher alcohols in the Ehrlich pathway. During microbiological culturing and industrial fermentations, this yeast is confronted with amino acids modified by reducing sugars in the Maillard reaction (glycation). In order to get first insights into the physiological "handling" of glycated amino acids by yeasts, individual Maillard reaction products (MRPs; fructosyllysine, carboxymethyllysine, pyrraline, formyline, maltosine, methylglyoxal-derived hydroimidazolone) were administered to two strains of S...
November 30, 2016: Chembiochem: a European Journal of Chemical Biology
https://www.readbyqxmd.com/read/27898943/effects-of-feeding-fermented-wheat-with-on-gut-morphology-intestinal-fermentation-nutrient-digestibility-and-growth-performance-in-weaned-pigs
#7
M H A Le, S Galle, Y Yang, J L Landero, E Beltranena, M G Gänzle, R T Zijlstra
Feeding fermented feed to weaned pigs may improve nutrient digestibility and gut health and thereby reduce diarrhea incidence. Effects of feeding wheat grain fermented for 24 h with were evaluated with 36 weaned pigs (7.3 kg BW). Fermented wheat grain contained (DM basis) 14.2% CP, 0.45% chemically available Lys, and 7.8% NDF, whereas unfermented wheat grain contained 16.4% CP, 0.45% chemically available Lys, and 9.9% NDF. Pigs were fed 6 mash wheat-based diets balanced for water content during 2 phases: Phase 1 diets for 1 wk (d 0-7) with 20% unfermented or fermented wheat and, subsequently, Phase 2 diets for 2 wk (d 8-21) with 50% unfermented or fermented wheat...
November 2016: Journal of Animal Science
https://www.readbyqxmd.com/read/27898907/apparent-total-tract-macronutrient-digestibility-fecal-characteristics-and-fecal-fermentative-end-product-concentrations-of-healthy-adult-dogs-fed-bioprocessed-soy-protein
#8
A N Beloshapka, M R C de Godoy, K B Detweiler, M Newcomb, K H Ellegård, G C Fahey, K S Swanson
Animal proteins are commonly used in extruded dog foods. Plant-based proteins have a more consistent nutrient profile than animal sources but may contain antinutritional factors, including trypsin inhibitors and oligosaccharides. Bioprocessed soy protein (SP; HP-300; Hamlet Protein, Inc., Findlay, OH) is a processed soy-based product with low antinutritional factor concentrations and high protein quality. The objective was to evaluate the effects of SP on apparent total tract macronutrient digestibility, fecal characteristics, and fecal fermentative end products...
September 2016: Journal of Animal Science
https://www.readbyqxmd.com/read/27898682/genetic-predisposition-to-an-impaired-metabolism-of-the-branched-chain-amino-acids-and-risk-of-type-2-diabetes-a-mendelian-randomisation-analysis
#9
Luca A Lotta, Robert A Scott, Stephen J Sharp, Stephen Burgess, Jian'an Luan, Therese Tillin, Amand F Schmidt, Fumiaki Imamura, Isobel D Stewart, John R B Perry, Luke Marney, Albert Koulman, Edward D Karoly, Nita G Forouhi, Rasmus J O Sjögren, Erik Näslund, Juleen R Zierath, Anna Krook, David B Savage, Julian L Griffin, Nishi Chaturvedi, Aroon D Hingorani, Kay-Tee Khaw, Inês Barroso, Mark I McCarthy, Stephen O'Rahilly, Nicholas J Wareham, Claudia Langenberg
BACKGROUND: Higher circulating levels of the branched-chain amino acids (BCAAs; i.e., isoleucine, leucine, and valine) are strongly associated with higher type 2 diabetes risk, but it is not known whether this association is causal. We undertook large-scale human genetic analyses to address this question. METHODS AND FINDINGS: Genome-wide studies of BCAA levels in 16,596 individuals revealed five genomic regions associated at genome-wide levels of significance (p < 5 × 10-8)...
November 2016: PLoS Medicine
https://www.readbyqxmd.com/read/27895003/effect-on-nitrogen-balance-thermogenesis-body-composition-satiety-and-circulating-branched-chain-amino-acid-levels-up-to-one-year-after-surgery-protocol-of-a-randomized-controlled-trial-on-dietary-protein-during-surgical-weight-loss
#10
Violeta Moizé, Xavier Pi-Sunyer, Josep Vidal, Patricia Miner, Yves Boirie, Blandine Laferrère
BACKGROUND: Bariatric surgery (BS), the most effective treatment for severe obesity, typically results in 40-50 kg weight loss in the year following the surgery. Beyond its action on protein metabolism, dietary protein intake (PI) affects satiety, thermogenesis, energy efficiency, and body composition (BC). However, the required amount of PI after surgical weight loss is not known. The current daily PI recommendation for diet-induced weight loss is 0.8 g/kg ideal body weight (IBW) per day, but whether this amount is sufficient to preserve fat-free mass during active surgical weight loss is unknown...
November 28, 2016: JMIR Research Protocols
https://www.readbyqxmd.com/read/27891833/metabolomics-guided-insights-on-bariatric-surgery-versus-behavioral-interventions-for-weight-loss
#11
REVIEW
Sara Tulipani, Jules Griffin, Magali Palau-Rodriguez, Ximena Mora-Cubillos, Rosa M Bernal-Lopez, Francisco J Tinahones, Barbara E Corkey, Cristina Andres-Lacueva
OBJECTIVE: To review the metabolomic studies carried out so far to identify metabolic markers associated with surgical and dietary treatments for weight loss in subjects with obesity. METHODS: The Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines were followed. RESULTS: Thirty-two studies successfully met the eligibility criteria. The metabolic adaptations shared by surgical and dietary interventions mirrored a state of starvation ketoacidosis (increase of circulating ketone bodies), an increase of acylcarnitines and fatty acid β-oxidation, a decrease of specific amino acids including branched-chain amino acids (BCAA) and (lyso)glycerophospholipids previously associated with obesity, and adipose tissue expansion...
December 2016: Obesity
https://www.readbyqxmd.com/read/27890800/metabolic-responses-of-haliotis-diversicolor-to-vibrio-parahaemolyticus-infection
#12
Jie Lu, Yanyan Shi, Shuhui Cai, Jianghua Feng
Vibrio parahemolyticus is a devastating bacterial pathogen that often causes outbreak of vibriosis in abalone Haliotis diversicolor. Elucidation of metabolic mechanisms of abalones in responding to V. parahemolyticus infection is essential for controlling the epidemic. In this work, (1)H NMR-based metabolomic techniques along with correlation and network analyses are used to investigate characteristic metabolites, as well as corresponding disturbed pathways in hepatopancreas and gill of H. diversicolor after V...
November 24, 2016: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/27886623/liver-bcatm-transgenic-mouse-model-reveals-the-important-role-of-the-liver-in-maintaining-bcaa-homeostasis
#13
Elitsa A Ananieva, Cynthia G Van Horn, Meghan R Jones, Susan M Hutson
Unlike other amino acids, the branched-chain amino acids (BCAAs) largely bypass first-pass liver degradation due to a lack of hepatocyte expression of the mitochondrial branched-chain aminotransferase (BCATm). This sets up interorgan shuttling of BCAAs and liver-skeletal muscle cooperation in BCAA catabolism. To explore whether complete liver catabolism of BCAAs may impact BCAA shuttling in peripheral tissues, the BCATm gene was stably introduced into mouse liver. Two transgenic mouse lines with low and high hepatocyte expression of the BCATm transgene (LivTg-LE and LivTg-HE) were created and used to measure liver and plasma amino acid concentrations and determine whether the first two BCAA enzymatic steps in liver, skeletal muscle, heart and kidney were impacted...
November 2, 2016: Journal of Nutritional Biochemistry
https://www.readbyqxmd.com/read/27885628/bcaa-metabolism-and-nh3-homeostasis
#14
M E Conway, S M Hutson
The branched chain amino acids (BCAA) are essential amino acids required not only for growth and development, but also as nutrient signals and as nitrogen donors to neurotransmitter synthesis and glutamate/glutamine cycling. Transamination and oxidative decarboxylation of the BCAAs are catalysed by the branched-chain aminotransferase proteins (BCATm, mitochondrial and BCATc, cytosolic) and the branched-chain α-keto acid dehydrogenase enzyme complex (BCKDC), respectively. These proteins show tissue, cell compartmentation, and protein-protein interactions, which call for substrate shuttling or channelling and nitrogen transfer for oxidation to occur...
2016: Advances in Neurobiology
https://www.readbyqxmd.com/read/27883272/circulating-adipocyte-derived-exosomal-micrornas-associated-with-decreased-insulin-resistance-after-gastric-bypass
#15
Monica J Hubal, Evan P Nadler, Sarah C Ferrante, Matthew D Barberio, Jung-Hyuk Suh, Justin Wang, G Lynis Dohm, Walter J Pories, Michelle Mietus-Snyder, Robert J Freishtat
OBJECTIVE: Exosomes from obese adipose contain dysregulated microRNAs linked to insulin signaling, as compared with lean controls, providing a direct connection between adiposity and insulin resistance. This study tested the hypotheses that gastric bypass surgery and its subsequent weight loss would normalize adipocyte-derived exosomal microRNAs associated with insulin signaling and the associated metabolome related to glucose homeostasis. METHODS: African American female subjects with obesity (N = 6; age: 38...
November 24, 2016: Obesity
https://www.readbyqxmd.com/read/27881392/higher-serum-phenylalanine-concentration-is-associated-with-more-rapid-telomere-shortening-in-men
#16
Johan G Eriksson, Maria-Angela Guzzardi, Patricia Iozzo, Eero Kajantie, Hannu Kautiainen, Minna K Salonen
BACKGROUND: Telomere length and telomere shortening are associated with age-related health outcomes. Only a few studies have been able to longitudinally report on factors that are associated with changes in telomere length in an aging population. OBJECTIVE: We studied the longitudinal relation between telomere length, the change in telomere length, and circulating amino acids. DESIGN: A total of 812 subjects from the Helsinki Birth Cohort Study (born from 1934 to 1944), who underwent 3 clinical visits during a 10-y interval that included measurements of cardiometabolic risk factors, were included in the study...
November 23, 2016: American Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/27873095/oral-branched-chain-amino-acid-granules-improve-structure-and-function-of-human-serum-albumin-in-cirrhotic-patients
#17
Hiroko Setoyama, Motohiko Tanaka, Kohei Nagumo, Hideaki Naoe, Takehisa Watanabe, Youko Yoshimaru, Masakuni Tateyama, Masato Sasaki, Hiroshi Watanabe, Masaki Otagiri, Toru Maruyama, Yutaka Sasaki
BACKGROUND AND AIMS: The aim of this study was to evaluate structural and functional alterations of human serum albumin (HSA), with a special focus on the oxidized and reduced forms, in patients with chronic liver disease. We also investigated whether oral branched-chain amino acid (BCAA) supplementation could induce structural changes and improve the functions of HSA. METHODS: The proportion of reduced and oxidized HSA was determined in 16 healthy controls and in 20 chronic hepatitis and 100 cirrhotic patients with stable conditions...
November 21, 2016: Journal of Gastroenterology
https://www.readbyqxmd.com/read/27872968/new-functions-and-potential-applications-of-amino-acids
#18
Hisayuki Uneyama, Hisamine Kobayashi, Naoto Tonouchi
Currently, several types of amino acids are being produced and used worldwide. Nevertheless, several new functions of amino acids have been recently discovered that could result in other applications. For example, oral stimulation by glutamate triggers the cephalic phase response to prepare for food digestion. Further, the stomach and intestines have specific glutamate-recognizing systems in their epithelial mucosa. Regarding clinical applications, addition of monosodium glutamate to the medicinal diet has been shown to markedly enhance gastric secretion in a vagus-dependent manner...
November 22, 2016: Advances in Biochemical Engineering/biotechnology
https://www.readbyqxmd.com/read/27872960/branched-chain-amino-acids
#19
Keisuke Yamamoto, Atsunari Tsuchisaka, Hideaki Yukawa
Branched-chain amino acids (BCAAs), viz., L-isoleucine, L-leucine, and L-valine, are essential amino acids that cannot be synthesized in higher organisms and are important nutrition for humans as well as livestock. They are also valued as synthetic intermediates for pharmaceuticals. Therefore, the demand for BCAAs in the feed and pharmaceutical industries is increasing continuously. Traditional industrial fermentative production of BCAAs was performed using microorganisms isolated by random mutagenesis. A collection of these classical strains was also scientifically useful to clarify the details of the BCAA biosynthetic pathways, which are tightly regulated by feedback inhibition and transcriptional attenuation...
November 22, 2016: Advances in Biochemical Engineering/biotechnology
https://www.readbyqxmd.com/read/27872244/network-guided-gwas-improves-identification-of-genes-affecting-free-amino-acids
#20
Ruthie Angelovici, Albert Batushansky, Nicholas Deason, Sabrina Gonzalez-Jorge, Michael A Gore, Aaron Fait, Dean DellaPenna
Amino acids (AA) are essential for proper growth and development in plants. AAs serve as building blocks for proteins but also are important for responses to stresses and the biosynthesis of numerous essential compounds. In seed, the pool of free amino acids (FAA) also contributes to alternative energy, desiccation, and seed vigor; thus, manipulating FAA levels can significantly impact a seed's nutritional qualities. While genome-wide association studies (GWAS) on branched chain amino acids have identified some regulatory genes controlling seed FAAs, the genetic regulation of FAA levels, composition, and homeostasis in seeds remains mostly unresolved...
November 21, 2016: Plant Physiology
keyword
keyword
62371
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"