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Spinal cord stimulators

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https://www.readbyqxmd.com/read/29786465/trunk-stability-enabled-by-non-invasive-spinal-electrical-stimulation-after-spinal-cord-injury
#1
Mrinal Rath, Albert H Vette, Shyamsundar Ramasubramaniam, Kun Li, Joel Burdick, Victor Reggie Edgerton, Yury Gerasimenko, Dimitry Sayenko
Electrical neuromodulation of spinal networks improves the control of movement of the paralyzed limbs after spinal cord injury (SCI). However, the potential of non-invasive spinal stimulation to facilitate postural trunk control during sitting in humans with SCI has not been investigated. We hypothesized that transcutaneous electrical stimulation of the lumbosacral enlargement can improve trunk posture. Eight participants with non-progressive SCI, C3-T9, AIS A or C, performed different motor tasks during sitting...
May 22, 2018: Journal of Neurotrauma
https://www.readbyqxmd.com/read/29777277/impact-of-muscle-atrophy-on-bone-metabolism-and-bone-strength-implications-for-muscle-bone-crosstalk-with-aging-and-disuse
#2
REVIEW
T Bettis, B-J Kim, M W Hamrick
Bone fractures in older adults are often preceded by a loss of muscle mass and strength. Likewise, bone loss with prolonged bed rest, spinal cord injury, or with exposure to microgravity is also preceded by a rapid loss of muscle mass. Recent studies using animal models in the setting of hindlimb unloading or botulinum toxin (Botox) injection also reveal that muscle loss can induce bone loss. Moreover, muscle-derived factors such as irisin and leptin can inhibit bone loss with unloading, and knockout of catabolic factors in muscle such as the ubiquitin ligase Murf1 or the myokine myostatin can reduce osteoclastogenesis...
May 18, 2018: Osteoporosis International
https://www.readbyqxmd.com/read/29774960/alteration-of-nociceptive-integration-in-the-spinal-cord-of-a-rat-model-of-parkinson-s-disease
#3
Keri-Ann Charles, Frédéric Naudet, Rabia Bouali-Benazzouz, Marc Landry, Philippe De Deurwaerdère, Pascal Fossat, Abdelhamid Benazzouz
BACKGROUND: Pain is a major non motor symptom that contributes to impaired quality of life in PD. However, its mechanism is unknown. OBJECTIVES AND METHODS: We sought to identify the pain phenotypes and parallel changes in spinal integration of peripheral stimuli in a rat model of PD induced by lesions of SN dopamine neurons, using behavioral plantar and von Frey tests as well as electrophysiology of the dorsal horn. RESULTS: We show that dopamine depletion by 6-OHDA induced hypersensitivity to mechanical and thermal stimuli...
May 18, 2018: Movement Disorders: Official Journal of the Movement Disorder Society
https://www.readbyqxmd.com/read/29774436/management-of-erectile-dysfunction-and-infertility-in-the-male-spinal-cord-injury-patient
#4
REVIEW
Michael Fenstermaker, James M Dupree, Miriam Hadj-Moussa, Dana A Ohl
PURPOSE OF REVIEW: Men with spinal cord injury (SCI) commonly suffer from erectile dysfunction and ejaculatory dysfunction. The literature regarding the causes and treatment of these two important problems was reviewed. RECENT FINDINGS: Many of the erectile dysfunction treatments applied to able bodied individuals are also useful in the SCI population, although there are differences in the goals and results of treatment. Ejaculatory dysfunction can be treated with either penile vibratory stimulation or electroejaculation with high success rates...
May 17, 2018: Current Urology Reports
https://www.readbyqxmd.com/read/29771608/paced-breathing-and-phrenic-nerve-responses-evoked-by-epidural-stimulation-following-complete-high-cervical-spinal-cord-injury-in-rats
#5
Tatiana Bezdudnaya, Michael A Lane, Vitaliy Marchenko
Spinal cord injury (SCI) at the level of cervical segments often results in life-threatening respiratory complications and requires long-term mechanical ventilator assistance. Thus, restoring diaphragm activity and regaining voluntary control of breathing are the primary clinical goals for patients with respiratory dysfunction following cervical SCI. Epidural stimulation (EDS) is a promising strategy that has been explored extensively for non-respiratory functions, and to a limited extent within the respiratory system...
May 17, 2018: Journal of Applied Physiology
https://www.readbyqxmd.com/read/29771606/improved-motor-unit-number-estimate-when-motor-unit-alternation-is-addressed
#6
Bradley A DeForest, Jeffrey Winslow, Christine K Thomas
Motor unit number estimation (MUNE) is important for determining motoneuron survival with age or in conditions such as amyotrophic lateral sclerosis or spinal cord injury. The original incremental method, or approaches introduced to minimize alternation (e.g. multiple point stimulation), are most commonly used but accept the limitation that alternation of motor units may still inflate the estimate. Alternation occurs because axon thresholds are probabilistic and overlap for different axons, therefore different combination of motor units may respond at a given stimulus intensity...
May 17, 2018: Journal of Applied Physiology
https://www.readbyqxmd.com/read/29765188/influence-of-peripheral-magnetic-stimulation-of-soleus-muscle-on-h-and-m-waves
#7
Tadamitsu Matsuda, Taichi Kurayama, Miki Tagami, Yuji Fujino, Atsushi Manji, Yasuaki Kusumoto, Kazu Amimoto
[Purpose] This study evaluated the effects of repetitive peripheral magnetic stimulation of the soleus muscle on spinal cord and peripheral motor nerve excitability. [Subjects and Methods] Twelve healthy adults (mean age 22 years) who provided written informed consent were administered repetitive peripheral magnetic stimulation for 10 min. Pre-and post-stimulation latencies and amplitudes of H- and M-waves of the soleus muscle were measured using electromyography and compared using paired t-tests. [Results] Pre- and post-stimulation latencies (28...
May 2018: Journal of Physical Therapy Science
https://www.readbyqxmd.com/read/29763654/obturator-neuromodulation-with-laparoscopic-placement-of-an-obturator-lead-for-the-treatment-of-intractable-opioid-dependent-chronic-pelvic-pain-due-to-obturator-neuralgia
#8
Richard P Marvel
Chronic pelvic pain(CPP) is a common condition in women that can have a devastating effect on quality of life. Some of the most severe forms of CPP are related to peripheral nerve injuries causing persistent neuropathic pain. This is a case of a young woman with severe opioid dependent chronic pelvic and right groin pain due to obturator neuralgia. She had failed a multitude of treatments including multiple medications, manual physical therapy, nerve blocks, surgical neurolysis and spinal cord stimulation without significant benefit...
May 12, 2018: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/29760484/top-down-descending-facilitation-of-spinal-sensory-excitatory-transmission-from-the-anterior-cingulate-cortex
#9
Tao Chen, Wataru Taniguchi, Qi-Yu Chen, Hidetoshi Tozaki-Saitoh, Qian Song, Ren-Hao Liu, Kohei Koga, Tsuyoshi Matsuda, Yae Kaito-Sugimura, Jian Wang, Zhi-Hua Li, Ya-Cheng Lu, Kazuhide Inoue, Makoto Tsuda, Yun-Qing Li, Terumasa Nakatsuka, Min Zhuo
Spinal sensory transmission is under descending biphasic modulation, and descending facilitation is believed to contribute to chronic pain. Descending modulation from the brainstem rostral ventromedial medulla (RVM) has been the most studied, whereas little is known about direct corticospinal modulation. Here, we found that stimulation in the anterior cingulate cortex (ACC) potentiated spinal excitatory synaptic transmission and this modulation is independent of the RVM. Peripheral nerve injury enhanced the spinal synaptic transmission and occluded the ACC-spinal cord facilitation...
May 14, 2018: Nature Communications
https://www.readbyqxmd.com/read/29758384/disruption-of-shp1-nmda-receptor-signaling-in-spinal-cord-dorsal-horn-alleviated-inflammatory-pain
#10
Li Yang, Hu-Hu Bai, Zi-Yang Zhang, Jiang-Ping Liu, Zhan-Wei Suo, Xian Yang, Xiao-Dong Hu
Src-homology 2 domain-containing protein tyrosine phosphatase-1 (SHP1) is one of the non-receptor-like phosphatases that are highly enriched in hematopoietic cells. Although accumulating evidence has implicated the protein tyrosine phosphatases in the regulation of nociceptive transmission and plasticity, it is largely unknown whether SHP1 was expressed in pain-related spinal cord dorsal horn and engaged in the synaptic modification of nociceptive signals. Here we found that SHP1 was present in spinal neurons of rats and functionally coupled to GluN2A subunit-containing N-methyl-d-aspartate subtype of glutamate receptors, one of the key players in central sensitization of nociceptive behaviors...
April 30, 2018: Neuropharmacology
https://www.readbyqxmd.com/read/29757756/extraforaminal-lumbar-nerve-root-stimulation-for-neuropathic-pain-a-case-report
#11
Shunsuke Ishizaka, Mami Tsuda, Eiichirou Urasaki
Electrical stimulation of the spinal cord is commonly used to treat neuropathic pain. However, epidural space adhesion caused by previous surgery may interfere with precise electrical lead placement. We here report a case of successful placement of electrical leads via an extraforaminal approach in the management of recurrent pain after primary spinal cord stimulation. Extraforaminal nerve root stimulation may be an alternative choice for repeated epidural spinal cord stimulation in cases of recurrent neuropathic pain...
May 11, 2018: A&A practice
https://www.readbyqxmd.com/read/29755338/a-review-of-the-pedunculopontine-nucleus-in-parkinson-s-disease
#12
REVIEW
Isobel T French, Kalai A Muthusamy
The pedunculopontine nucleus (PPN) is situated in the upper pons in the dorsolateral portion of the ponto-mesencephalic tegmentum. Its main mass is positioned at the trochlear nucleus level, and is part of the mesenphalic locomotor region (MLR) in the upper brainstem. The human PPN is divided into two subnuclei, the pars compacta (PPNc) and pars dissipatus (PPNd), and constitutes both cholinergic and non-cholinergic neurons with afferent and efferent projections to the cerebral cortex, thalamus, basal ganglia (BG), cerebellum, and spinal cord...
2018: Frontiers in Aging Neuroscience
https://www.readbyqxmd.com/read/29752872/functional-neuroimaging-of-nociceptive-and-pain-related-activity-in-the-spinal-cord-and-brain-insights-from-neurovascular-coupling-studies
#13
Thierry Paquette, Renaud Jeffrey-Gauthier, Hugues Leblond, Mathieu Piché
Spinal cord and brain processes underlie pain perception, which produces systemic cardiovascular changes. In turn, the autonomic nervous system regulates vascular function in the spinal cord and brain in order to adapt to these systemic changes, while neuronal activity induces local vascular changes. Thus, autonomic regulation and pain processes in the brain and spinal cord are tightly linked and interrelated. The objective of this topical review is to discuss work on neurovascular coupling during nociceptive processing in order to highlight supporting evidence and limitations for the use of cerebral and spinal fMRI to investigate pain mechanisms and spinal nociceptive processes...
May 12, 2018: Anatomical Record: Advances in Integrative Anatomy and Evolutionary Biology
https://www.readbyqxmd.com/read/29752242/automated-fes-for-upper-limb-rehabilitation-following-stroke-and-spinal-cord-injury
#14
Edmund F Hodkin, Yuming Lei, Jonathan Humby, Isabel S Glover, Supriyo Choudhury, Hrishikesh Kumar, Monica A Perez, Helen Rodgers, Andrew Jackson
Neurorehabilitation aims to induce beneficial neural plasticity in order to restore function following injury to the nervous system. There is an increasing evidence that appropriately timed functional electrical stimulation (FES) can promote associative plasticity, but the dosage is critical for lasting functional benefits. Here, we present a novel approach to closed-loop control of muscle stimulation for the rehabilitation of reach-to-grasp movements following stroke and spinal cord injury (SCI). We developed a simple, low-cost device to deliver assistive stimulation contingent on users' self-initiated movements...
May 2018: IEEE Transactions on Neural Systems and Rehabilitation Engineering
https://www.readbyqxmd.com/read/29750900/robot-guided-neuronavigated-repetitive-transcranial-magnetic-stimulation-rtms-in-central-neuropathic-pain-an-update-of-long-term-follow-up
#15
Charles Quesada, Benjamin Pommier, Camille Fauchon, Claire Bradley, Christelle Créac'h, François Vassal, Roland Peyron
OBJECTIVE: To confirm and extend previous results involving repetitive transcranial magnetic stimulation (rTMS) aimed at alleviating refractory central neuropathic pain(CNP). To evaluate pain relief in detail and to assess ongoing benefits after one year of treatment. DESIGN: Prospective observational study. SETTING: University hospital. Outpatient settings. PARTICIPANTS: 80 patients with chronic central pain after brain or spinal cord injuries...
May 8, 2018: Archives of Physical Medicine and Rehabilitation
https://www.readbyqxmd.com/read/29745562/-measuring-functional-core-regions-of-hindlimb-movement-control-in-the-rat-spinal-cord-with-intraspinal-microstimulation
#16
Yi Chen, Lei Ma, Wei Du, Xiaoyan Shen
In order to improve the accuracy and reliability of the electrodes implant location when using spinal functional electrical stimulation to rebuild hindlimb motor function, we measured the distributions of function core regions in rat spinal cord associated with hindlimb movements. In this study, we utilized three-dimensional scanning intraspinal microstimulation technology to stimulate the rat spinal cord to generate hip, knee and ankle joint movements, and acquired the coordinates of the sites in spinal cord which evoked these movements...
August 1, 2017: Sheng Wu Yi Xue Gong Cheng Xue za Zhi, Journal of Biomedical Engineering, Shengwu Yixue Gongchengxue Zazhi
https://www.readbyqxmd.com/read/29744665/effect-of-spinal-anterior-root-stimulation-and-sacral-deafferentation-on-bladder-and-sexual-dysfunction-in-spinal-cord-injury
#17
Hamed Zaer, Mikkel Mylius Rasmussen, Franko Zepke, Charlotte Bodin, Burkhard Domurath, Johannes Kutzenberger
BACKGROUND: Spinal cord injury (SCI) is a highly devastating injury with a variety of complications; among them are neurogenic bladder, bowel, and sexual dysfunction. We aimed to evaluate the effect of sacral anterior root stimulation with sacral deafferentation (SARS-SDAF) on neurogenic bladder and sexual dysfunction in a large well-defined spinal cord injury cohort. METHODS: In the manner of cross-sectional study, subjects undergone SARS-SDAF between September 1986 and July 2011 answered a questionnaire concerning conditions before and after surgery in the department of Neuro-Urology, Bad Wildungen, Germany...
May 10, 2018: Acta Neurochirurgica
https://www.readbyqxmd.com/read/29742699/effect-of-photobiomodulation-treatment-in-the-sublingual-radial-artery-region-and-along-the-spinal-column-in-individuals-with-multiple-sclerosis-protocol-for-a-randomized-controlled-double-blind-clinical-trial
#18
RANDOMIZED CONTROLLED TRIAL
Tamiris da Silva, Fernanda Cordeiro da Silva, Andréa Oliver Gomes, Ariane Oliveira Viana, Marcela Letícia Leal Gonçalves, Maria Fernanda Setúbal Destro Rodrigues, Anna Carolina Ratto Tempestini Horliana, Daniela de Fátima Teixeira da Silva, Maria Cristina Chavantes, Yara Dadalti Fragoso, Luciana Prats Branco, Lara Jansiski Motta, Kristianne Porta Santos Fernandes, Raquel Agnelli Mesquita-Ferrari, Sandra Kalil Bussadori
BACKGROUND: Multiple sclerosis (MS) is an autoimmune disease, for which the forms of treatment are medication and rehabilitation. However, in vitro and in vivo studies have demonstrated that photobiomodulation can be an effective treatment modality for inflammatory diseases, including MS. Photobiomodulation has a broad range of benefits, such as the avoidance of cell and tissue death, the stimulation of healing and injury repair, reductions in pain, edema and inflammation, cell proliferation, and even apoptosis...
May 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29740270/therapeutic-effect-of-platelet-rich-plasma-in-rat-spinal-cord-injuries
#19
Nan-Fu Chen, Chun-Sung Sung, Zhi-Hong Wen, Chun-Hong Chen, Chien-Wei Feng, Han-Chun Hung, San-Nan Yang, Kuan-Hao Tsui, Wu-Fu Chen
Platelet-rich plasma (PRP) is prepared by centrifuging fresh blood in an anticoagulant state, and harvesting the platelet-rich portion or condensing platelets. Studies have consistently demonstrated that PRP concentrates are an abundant source of growth factors, such as platelet-derived growth factor (PDGF), transforming growth factor β (TGF-β), insulin-like growth factor 1 (IGF-1), and epithelial growth factor (EGF). The complex mechanisms underlying spinal cord injury (SCI) diminish intrinsic repair and neuronal regeneration...
2018: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/29740068/sub-paresthesia-spinal-cord-stimulation-reverses-thermal-hyperalgesia-and-modulates-low-frequency-eeg-in-a-rat-model-of-neuropathic-pain
#20
Suguru Koyama, Jimmy Xia, Brian W Leblanc, Jianwen Wendy Gu, Carl Y Saab
Paresthesia, a common feature of epidural spinal cord stimulation (SCS) for pain management, presents a challenge to the double-blind study design. Although sub-paresthesia SCS has been shown to be effective in alleviating pain, empirical criteria for sub-paresthesia SCS have not been established and its basic mechanisms of action at supraspinal levels are unknown. We tested our hypothesis that sub-paresthesia SCS attenuates behavioral signs of neuropathic pain in a rat model, and modulates pain-related theta (4-8 Hz) power of the electroencephalogram (EEG), a previously validated correlate of spontaneous pain in rodent models...
May 8, 2018: Scientific Reports
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