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controlled ovarian stimulation

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https://www.readbyqxmd.com/read/28095884/optimal-fsh-usage-in-revascularization-of-allotransplanted-ovarian-tissue-in-mice
#1
Wen-Zhi Ma, Xiao-Min Zheng, Chang-Chun Hei, Cheng-Jun Zhao, Sha-Sha Xie, Qing Chang, Yu-Fang Cai, Hua Jia, Xiu-Ying Pei, Yan-Rong Wang
BACKGROUD: Ovarian transplantation is a useful method for preserving the fertility of young women with cancer who undergo radiotherapy and chemotherapy. Follicle-stimulating hormone (FSH) is use to protect transplanted ovarian tissues from ischemia injury through promoting revascularization after transplantation, but the side effect of high level FSH is ovarian overstimulation leading to substantial follicular loss. In this study, we investigated the optimal usage of FSH on revascularization in the in vitro cultured ovarian tissues before and after transplantation...
January 17, 2017: Journal of Ovarian Research
https://www.readbyqxmd.com/read/28090462/pretreatment-of-normal-responders-in-fresh-in-vitro-fertilization-cycles-a-comparison-of-transdermal-estradiol-and-oral-contraceptive-pills
#2
Nigel Pereira, Allison C Petrini, Zhen N Zhou, Jovana P Lekovich, Isaac Kligman, Zev Rosenwaks
OBJECTIVE: The aim of this study was to investigate the impact of pretreatment with transdermal estradiol (E2) compared to oral contraceptive pills (OCPs) on controlled ovarian stimulation (COS) response in normal responders undergoing fresh in vitro fertilization (IVF)-embryo transfer (ET) cycles. METHODS: A retrospective cohort study was performed of normal responders undergoing fresh IVF-ET cycles who received pretreatment with transdermal E2 versus OCPs prior to fresh IVF-ET...
December 2016: Clinical and Experimental Reproductive Medicine
https://www.readbyqxmd.com/read/28081480/does-the-addition-of-salpingectomy-or-fimbriectomy-to-hysterectomy-in-premenopausal-patients-compromise-ovarian-reserve-a-prospective-study
#3
Y Naaman, Y Hazan, M Gillor, G Marciano, R Bardenstein, Z Shoham, A Ben-Arie
OBJECTIVE: To evaluate changes in ovarian reserve in patients following hysterectomy, with or without bilateral salpingectomy or fimbriectomy. STUDY DESIGN: Open-label, prospective cohort trial of patients undergoing hysterectomy for benign uterine indications. Levels of follicle-stimulating hormone (FSH), anti-Müllerian hormone (AMH), and ultrasonic measures of peak systolic flow velocity/diastolic velocity (S/D) ratio and resistance index (RI) in the ovarian artery were taken from patients before and 6 weeks after hysterectomy, hysterectomy+salpingectomy or hysterectomy+fimbriectomy...
December 27, 2016: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/28074124/involvement-of-blood-mononuclear-cells-in-the-infertility-age-associated-diseases-and-cancer-treatment
#4
REVIEW
Antonin Bukovsky
Blood mononuclear cells consist of T cells and monocyte derived cells. Beside immunity, the blood mononuclear cells belong to the complex tissue control system (TCS), where they exhibit morphostatic function by stimulating proliferation of tissue stem cells followed by cellular differentiation, that is stopped after attaining the proper functional stage, which differs among various tissue types. Therefore, the term immune and morphostatic system (IMS) should be implied. The TCS-mediated morphostasis also consists of vascular pericytes controlled by autonomic innervation, which is regulating the quantity of distinct tissues in vivo...
December 26, 2016: World Journal of Stem Cells
https://www.readbyqxmd.com/read/28072471/the-negative-chronotropic-effect-in-rat-heart-stimulated-by-ultrasonic-pulses-role-of-sex-and-age
#5
Olivia C Coiado, William D O'Brien
OBJECTIVES: The goal of this study is to investigate the role of sex and age of the negative chronotropic effect after exposure of 3.5-MHz pulsed ultrasound (US) to the rat heart. METHODS: Forty F344 rats were exposed transthoracically to ultrasonic pulses at a duty factor of approximately 1.0% at 2.0-MPa peak rarefactional pressure amplitude. The transthoracic ultrasonic bursts were delivered consecutively in five 10-s intervals, that is, 10 s of 6-Hz pulse repetition frequency (PRF), 10 s of 5-Hz PRF, 10 s of 4-Hz PRF, 10 s of 5-Hz PRF, and 10 s of 6-Hz, for a 50-s total exposure duration...
January 10, 2017: Journal of Ultrasound in Medicine: Official Journal of the American Institute of Ultrasound in Medicine
https://www.readbyqxmd.com/read/28069901/bmp15-regulates-the-inhibin-activin-system-independently-of-ovulation-rate-control-in-sheep
#6
Anthony Estienne, Belén Lahoz, Peggy Jarrier, Loys Bodin, José Folch, José Luis Alabart, Stephane Fabre, Danielle Monniaux
Polymorphisms in the gene encoding bone morphogenetic protein 15 (BMP15) have been associated with multiple ovulations in sheep. As BMP15 regulates inhibin expression in rodents, we assumed that the ovarian inhibin/activin system could mediate part of the effect of BMP15 mutations in the regulation of ovulation rate in sheep. To answer this question, we have studied the effects of two natural loss-of-function mutations of BMP15 on the expression of components of this system. The FecX(R) and the FecX(Gr) mutations, when present respectively in Rasa Aragonesa ewes at the heterozygous state and in Grivette ewes at the homozygous state, were associated with a two-fold increase in ovulation rate...
January 9, 2017: Reproduction: the Official Journal of the Society for the Study of Fertility
https://www.readbyqxmd.com/read/28069482/ovarian-response-and-in-vitro-fertilization-outcomes-after-salpingectomy-does-salpingectomy-indication-matter
#7
Nigel Pereira, Katherine P Pryor, Anna Voskuilen-Gonzalez, Jovana P Lekovich, Rony T Elias, Steven D Spandorfer, Zev Rosenwaks
STUDY OBJECTIVE: To investigate whether the ovarian response and pregnancy outcomes of patients undergoing in vitro fertilization (IVF) after salpingectomy is affected by the underlying indication for salpingectomy. DESIGN: Retrospective cohort study. DESIGN: Classification: II-3. SETTING: University-affiliated fertility center. PATIENTS: All patients <37 years of age undergoing IVF within 12 months of laparoscopic salpingectomy...
January 6, 2017: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/28056703/does-gnrh-agonist-triggering-control-painful-symptom-scores-during-assisted-reproductive-technology-a-retrospective-study
#8
Mathilde Bourdon, Pietro Santulli, Dominique de Ziegler, Vanessa Gayet, Chloé Maignien, Louis Marcellin, Charles Chapron
OBJECTIVE: The aim of this study was to assess the progression of pain symptoms during assisted reproductive technology (ART) cycles following administration of GnRH agonist (GnRHa) versus human chorionic gonadotrophin (hCG) triggering. DESIGN: Observational cohort study. SETTING: A tertiary care university hospital in France. POPULATION: Patients who underwent ART programs. METHODS: Between January 01, 2014, and June 31, 2014, 122 cycles were allocated to 2 groups: GnRHa triggering with a scheduled differed embryo transfer (n = 57) or hCG triggering with a fresh embryo transfer (n = 70)...
January 1, 2017: Reproductive Sciences
https://www.readbyqxmd.com/read/28051220/the-influence-of-gonadotropins-on-clinico-biological-icsi-outcome-a-retrospective-comparative-study-rfsh-vs-hp-hmg
#9
Abdeljalil Khlifi, Olfa Kacem, Maher Maroueni, Leila Elgoul, Samir Hidar, Meriem Fekih, Sassi Boughizane, Habib Essaidi, Lassad Ben Regaya, Mohamed Bibi, Mounir Ajina, Hedi Khairi
Objective To investigate the difference in the outcome of ICSI-ET cycles among respondents patients, taking into account the molecule inducer of controlled ovarian stimulation: HP-hMG ou rFSH. Patients and Methods A comparative retrospective study over 62 months including a total of 1005 infertile couples, divided into two groups: HP-HMG (n=125) and rFSH (n=880). Results - The average numbers of retrieved oocytes and matures oocytes were significantly higher in rFSH group rFSH (7,94 ± 2,49, HP-HMG vs 9,05 ± 3,40, rFSH, p=0...
June 2016: La Tunisie Médicale
https://www.readbyqxmd.com/read/28050957/prediction-of-metaphase-ii-oocytes-according-to-different-serum-anti-m%C3%A3-llerian-hormone-amh-levels-in-antagonist-icsi-cycles
#10
Joyce B da Silva, Tatiana R Panaino, Maria A Tamm, Paloma Lira, Patricia C F Arêas, Ana C A Mancebo, Marcelo M de Souza, Roberto A Antunes, Maria do Carmo B de Souza
OBJECTIVE: This paper aims to assess a qualitative aspect of ovarian response in terms of metaphase II oocytes according to different serum Anti-Müllerian hormone levels in antagonist ICSI cycles. A prediction index might contribute to the individualization of care. METHODS: This observational study looked into 287 antagonist ICSI cycles carried out with patients treated in a single center between January of 2012 and January of 2016. Serum AMH and subgroup analyses were performed based on five AMH ranges (≤ 0...
December 1, 2016: JBRA Assisted Reproduction
https://www.readbyqxmd.com/read/28039066/estrogen-levels-influence-medullary-bone-quantity-and-density-in-female-house-finches-and-pine-siskins
#11
Maria E Squire, Megan K Veglia, Kevin A Drucker, Kathleen Brazeal, Thomas P Hahn, Heather E Watts
Medullary bone, a non-structural osseous tissue, serves as a temporary storage site for calcium that is needed for eggshell production in a number of avian species. Previous research focusing primarily on domesticated species belonging to the Anseriformes, Galliformes, and Columbiformes has indicated that rising estrogen levels are a key signal stimulating medullary bone formation; Passeriformes (which constitute over half of extant bird species and are generally small) have received little attention. In the current study, we examined the influence of estrogen on medullary bone and cortical bone in two species of Passeriformes: the Pine Siskin (Spinus pinus) and the House Finch (Haemorhous mexicanus)...
December 27, 2016: General and Comparative Endocrinology
https://www.readbyqxmd.com/read/28009430/timing-should-no-longer-be-an-obstacle-to-oocyte-cryopreservation-in-patients-with-cancer
#12
Giorgia Mangili, Enrico Papaleo, Cristina Sigismondi, Rossella Masciangelo, Veronica Sarais, Veronica Giorgione, Roberta Nale, Laura Privitera, Letizia Carnelli, Valentina Di Mattei, Massimo Candiani
PURPOSE: Anticancer treatment-related infertility is preventable with oocyte cryopreservation, but this is often not considered a relevant issue, due to lack of knowledge and time. The aim of this study is to prove that adequate organization of an Oncofertility Unit and the use of new protocols for controlled ovarian stimulation (COS) can reduce the time required by the procedure, encouraging consultants and patients to preserve fertility before gonadotoxic treatments. METHODS: A total of 125 patients diagnosed with malignant tumors were referred to the Oncofertility Unit of San Raffaele Hospital: 52 patients between April 2011 and October 2013 and 73 patients between October 2013 and November 2015...
November 28, 2016: Tumori
https://www.readbyqxmd.com/read/28008984/melatonin-implantation-improved-the-egg-laying-rate-and-quality-in-hens-past-their-peak-egg-laying-age
#13
Yaxiong Jia, Minghui Yang, Kuanfeng Zhu, Liang Wang, Yukun Song, Jing Wang, Wenxiang Qin, Zhiyuan Xu, Yu Chen, Guoshi Liu
The egg-laying rates of hens approximately 470 days of age exhibited a positive correlation to blood melatonin levels. The hens with an egg-laying rate <30%, 30~90% and ≥90% had blood melatonin levels of 5.8 ± 2.6, 74.0 ± 32.9 and 445.9 ± 115.3 ng/ml, respectively. When 10 mg of melatonin was implanted into the hens at 300, 360, 470 and 550 days of age, the egg-laying rates increased 4.63 ± 0.46%, 8.38 ± 1.45%, 4.93 ± 0.85% and 7.93 ± 0.91%, respectively, compared to that of the controls...
December 23, 2016: Scientific Reports
https://www.readbyqxmd.com/read/28004236/ghrelin-is-independently-associated-with-anti-mullerian-hormone-levels-in-obese-but-not-non-obese-women-with-polycystic-ovary-syndrome
#14
Margaret C Garin, Samantha F Butts, David B Sarwer, Kelly C Allison, Suneeta Senapati, Anuja Dokras
Ghrelin is an endogenous appetite stimulant that may have a role in ovarian function. Women with polycystic ovary syndrome have anovulation and frequently weight management issues; however the associations between ghrelin and hormonal markers in polycystic ovary syndrome have not been well studied. In order to characterize the association between total ghrelin levels and ovarian function and the possible modification of this relationship by obesity, we examined total ghrelin levels and anti-mullerian hormone, total testosterone, and insulin in obese and non-obese women with and without polycystic ovary syndrome...
December 21, 2016: Endocrine
https://www.readbyqxmd.com/read/27999118/effect-of-pretreatment-with-oral-contraceptives-and-progestins-on-ivf-outcomes-in-women-with-polycystic-ovary-syndrome
#15
Daimin Wei, Yuhua Shi, Jing Li, Ze Wang, Lin Zhang, Yun Sun, Hong Zhou, Yuping Xu, Chunxiang Wu, Ling Liu, Qiongfang Wu, Lili Zhuang, Yanzhi Du, Weiping Li, Heping Zhang, Richard S Legro, Zi-Jiang Chen
STUDY QUESTION: Do oral contraceptives (OCs) and progestins impact live birth rate of IVF when used for cycle scheduling in women with polycystic ovary syndrome (PCOS)? SUMMARY ANSWER: OCs used for scheduling IVF cycle were associated with lowered rates of pregnancy and live birth after fresh embryo transfer, whereas progestins used for this purpose yield higher rates of pregnancy and live birth than OCs. WHAT IS KNOWN ALREADY: Due to oligo-menorrhea in PCOS, OCs and progestin are extensively used to schedule the start of an IVF cycle in women with PCOS...
December 19, 2016: Human Reproduction
https://www.readbyqxmd.com/read/27994298/relationship-between-genotype-variants-follicle-stimulating-hormone-receptor-gene-polymorphisms-fshr-and-morphology-of-oocytes-prior-to-icsi-procedures
#16
Zafer Gashi, Shkelzen Elezaj, Afrim Zeqiraj, Driton Grabanica, Isak Shabani, Bujar Gruda, Fitore Gashi
INTRODUCTION: This study investigated association of Asn680Ser FSHR polymorphism with the ovarian response in 104 women of Albanian ethnic population enrolled in ICSI program. The reason of infertility in all cases has been identified as male factor. METHODS: Analysis of the Asn680Ser polymorphism was performed using TaqMan(®) SNP Genotyping Assay. Clinical and endocrinologic parameters were analyzed based on the genotype, age, BMI, oocyte yield, number of transferred embryos and pregnancy rate...
October 2016: Medical Archives
https://www.readbyqxmd.com/read/27993552/new-pcos-like-phenotype-in-older-infertile-women-of-likely-autoimmune-adrenal-etiology-with-high-amh-but-low-androgens
#17
Norbert Gleicher, Vitaly A Kushnir, Sarah K Darmon, Qi Wang, Lin Zhang, David F Albertini, David H Barad
How anti-Müllerian hormone (AMH) and testosterone (T) interrelate in infertile women is currently largely unknown. We, therefore, in a retrospective cohort study investigated how infertile women with high-AMH (AMH ≥75th quantile; n=144) and with normal-AMH (25th-75th quantile; n=313), stratified for low-T (total testosterone ≤19.0ng/dL), normal-T (19.0-29.0ng/dL) and high-T (>29.0ng/dL) phenotypically behaved. Patient age, follicle stimulating hormone (FSH), dehyroepiandrosterone (DHEA), DHEA sulphate (DHEAS), cortisol (C), adrenocorticotrophic hormone (ACTH), IVF outcomes, as well as inflammatory and immune panels were then compared between groups, with AMH and T as variables...
December 16, 2016: Journal of Steroid Biochemistry and Molecular Biology
https://www.readbyqxmd.com/read/27987339/evaluation-of-ovarian-reserve-using-anti-m%C3%A3-llerian-hormone-and-antral-follicle-count-in-sj%C3%A3-gren-s-syndrome-preliminary-study
#18
Savas Karakus, Ali Sahin, Yunus Durmaz, Huseyin Aydin, Caglar Yildiz, Ozlem Akkar, Mansur Dogan, Ahmet Cengiz, Meral Cetin, Ali Cetin
AIM: The aim of this study was to determine ovarian reserve status using anti-müllerian hormone (AMH) level and antral follicle count (AFC) in patients with Sjögren's syndrome (SS). METHODS: Twenty-four women with SS diagnosed according to the classification criteria proposed by the American-European Consensus Group and 25 healthy women as controls were enrolled in this study. Ovarian reserve was assessed on clinical findings, AFC, and serum AMH and reproductive hormone levels...
December 17, 2016: Journal of Obstetrics and Gynaecology Research
https://www.readbyqxmd.com/read/27987338/effect-of-interleukin-1%C3%AE-and-lipoxin-a4-in-human-endometriotic-stromal-cells-proteomic-analysis
#19
Rong-Feng Wu, Hui-Ming Yang, Wei-Dong Zhou, Li-Rong Zhang, Jian-Bing Bai, Dian-Chao Lin, Tai-Wei Ng, Song-Juan Dai, Qiong-Hua Chen, Qing-Xi Chen
AIM: Lipoxin A4 (LXA4 ) can function as an endogenous 'breaking signal' in inflammation and plays an important role in the progression of endometriosis. The proteome responses to interleukin-1β (IL-1β) or LXA4 in human endometriotic stromal cells (ESC) are not well understood. METHODS: In this study, primary ESC were cultured from ovarian endometriosis tissue. Three groups were established: the control group; the IL-1β stimulation group; and the IL-1β and LXA4 incubation group...
December 17, 2016: Journal of Obstetrics and Gynaecology Research
https://www.readbyqxmd.com/read/27986819/there-is-no-evidence-that-the-time-from-egg-retrieval-to-embryo-transfer-affects-live-birth-rates-in-a-freeze-all-strategy
#20
K Lattes, M A Checa, R Vassena, M Brassesco, V Vernaeve
STUDY QUESTION: Does the time from ovum pick-up (OPU) to frozen embryo transfer (FET) affect reproductive outcomes in a freeze-all strategy? SUMMARY ANSWER: Our study did not detect statistically significant differences between first and subsequent cycles, clinically relevant differences are not ruled out and further and larger studies are required. WHAT IS KNOWN ALREADY: Following controlled ovarian hyperstimulation (COH) delaying FET until the endometrium has returned to an optimal pre-stimulation state may have a significant emotional impact on patients, which adds to the stress and anxiety accompanying a standard IVF cycle...
December 16, 2016: Human Reproduction
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