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controlled ovarian stimulation

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https://www.readbyqxmd.com/read/27912901/individualized-versus-conventional-ovarian-stimulation-for-in%C3%A2-vitro-fertilization-a-multicenter-randomized-controlled-assessor-blinded-phase-3-noninferiority-trial
#1
Anders Nyboe Andersen, Scott M Nelson, Bart C J M Fauser, Juan Antonio García-Velasco, Bjarke M Klein, Joan-Carles Arce
OBJECTIVE: To compare the efficacy and safety of follitropin delta, a new human recombinant FSH with individualized dosing based on serum antimüllerian hormone (AMH) and body weight, with conventional follitropin alfa dosing for ovarian stimulation in women undergoing IVF. DESIGN: Randomized, multicenter, assessor-blinded, noninferiority trial (ESTHER-1). SETTING: Reproductive medicine clinics. PATIENT(S): A total of 1,329 women (aged 18-40 years)...
November 22, 2016: Fertility and Sterility
https://www.readbyqxmd.com/read/27908671/effect-of-gnrh-and-hcg-on-progesterone-concentration-and-ovarian-and-luteal-blood-flow-in-diestrous-mares
#2
L F C Brito, J M Baldrighi, C A Wolf, O J Ginther
The objective of the present study was to investigate the effect of reproductive hormones (GnRH, hCG, LH and progesterone) on the regulation of corpus luteum (CL) and ovarian blood flow. Diestrous mares received a single treatment of saline, 100μg gonadorelin (GnRH), or 1500IU hCG 10days after ovulation. Plasma LH and progesterone concentrations, resistance index (RI) for ovarian artery blood-flow, and percentage of corpus luteum (CL) with color-Doppler signals of blood flow were determined immediately before treatment (hour 0) and at hours 0...
November 23, 2016: Animal Reproduction Science
https://www.readbyqxmd.com/read/27901279/dopamine-agonists-for-preventing-ovarian-hyperstimulation-syndrome
#3
REVIEW
Huilin Tang, Selma Mourad, Suo-Di Zhai, Roger J Hart
BACKGROUND: Ovarian hyperstimulation syndrome (OHSS) is a potentially serious complication of ovarian stimulation in assisted reproduction technology (ART). It is characterised by enlarged ovaries and an acute fluid shift from the intravascular space to the third space, resulting in bloating, increased risk of venous thromboembolism and decreased organ perfusion. Most cases are mild, but forms of moderate or severe OHSS appear in 3% to 8% of in vitro fertilisation (IVF) cycles. The dopamine agonist cabergoline was introduced as a secondary prevention intervention for OHSS in women at high risk of OHSS undergoing ART treatment...
November 30, 2016: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/27899966/analysis-of-the-molecular-mechanism-of-osteosarcoma-using-a-bioinformatics-approach
#4
Jianxun Yang, Ning Wang
The aim of this study was to explore the underlying molecular mechanism related to the process and progression of osteosarcoma (OS). The differentially expressed genes (DEGs) were downloaded from the Gene Expression Omnibus database. The pathway and gene ontology (GO) enrichment analysis, as well as transcription factor, tumor-associated gene and tumor suppressor gene analyses were performed to investigate the functions of DEGs. Next, the protein-protein interaction (PPI) network was constructed and module analysis was further assessed by cluster analysis with the overlapping neighborhood expansion (Cluster ONE) cytoscape plug-in...
November 2016: Oncology Letters
https://www.readbyqxmd.com/read/27898708/influence-of-tp53-codon-72-polymorphism-alone-or-in-combination-with-hdm2-snp309-on-human-infertility-and-ivf-outcome
#5
Ying Chan, Baosheng Zhu, Hongguo Jiang, Jinman Zhang, Ying Luo, Wenru Tang
To evaluate the association of the TP53 codon 72 (rs 1042522) alone or in combination with HDM2 SNP309 (rs 2279744) polymorphisms with human infertility and IVF outcome, we collected 1450 infertility women undergoing their first controlled ovarian stimulation for IVF treatment and 250 fertile controls in the case-control study. Frequencies, distribution, interaction of genes, and correlation with infertility and IVF outcome of clinical pregnancy were analyzed. We found a statistically significant association between TP53 codon 72 polymorphism and IVF outcome (52...
2016: PloS One
https://www.readbyqxmd.com/read/27895776/establishment-of-specific-cytotoxic-t-lymphocyte-culture-system-and-its-inhibitory-effect-on-ovarian-cancer
#6
Mingxing Sui, Lihui Si, Tianmin Xu, Manhua Cui
The present study aimed to establish a novel method for efficiently inducing cytotoxic T lymphocytes (CTLs) in vitro, in order to develop an immune-based therapy for suppressing and killing ovarian cancer cells with a high safety and efficacy. Peripheral blood mononuclear cells (PBMCs) were stimulated with CpG oligodeoxynucleotide (CpGODN) and ginsenoside Rg1, which were united as an immune adjuvant, and human epidermal growth factor receptor 2 (HER2/neu) antigen peptide, in order to establish a specific CTL culture system in vitro...
November 2016: Oncology Letters
https://www.readbyqxmd.com/read/27895702/ameliorating-effect-of-erxian-decoction-combined-with-fructus-schisandrae-chinensis-wu-wei-zi-on-menopausal-sweating-and-serum-hormone-profiles-in-a-rat-model
#7
Shi Wei Wang, Fei Hua Wu, Yan Bo Zhang, Liang Zhang, Jing Su, Hei Kei Wong, Ai Hua Liu, Ho Pan Cheung, Tzi Bun Ng, Yao Tong, Stephen Cho Wing Sze
BACKGROUND: Modified Erxian decoction (MEXD), i.e., Erxian decoction (EXD) with Fructus Schisandrae chinensis (Wu Wei Zi) added, has been used to alleviate menopausal symptoms. This study aimed to investigate the effects of MEXD on menopausal sweating and serum hormone levels in a rat model of menopause after oral administration of MEXD. METHODS: Quality control of MEXD was conducted by employing a reversed-phase high performance liquid chromatography column. The three treatment groups received oral administration of MEXD in 0...
2016: Chinese Medicine
https://www.readbyqxmd.com/read/27889913/long-term-melatonin-treatment-delays-ovarian-aging
#8
Hiroshi Tamura, Mai Kawamoto, Shun Sato, Isao Tamura, Ryo Maekawa, Toshiaki Taketani, Hiromi Aasada, Eiichi Takaki, Akira Nakai, Russel J Reiter, Norihiro Sugino
Ovarian aging is characterized by gradual declines in oocyte quantity and quality. Melatonin is considered an anti-aging agent due to its cytoprotective actions as an antioxidant. The present study examined whether long-term melatonin treatment would delay ovarian aging in mice. Female ICR mice (10 weeks old) were given melatonin-containing water (100 μg/ml; melatonin) or water only until 43 weeks of age. Their oocytes were recovered from the oviduct, and in vitro fertilization was performed. The ovaries were used for a histological analysis of the number of follicles...
November 27, 2016: Journal of Pineal Research
https://www.readbyqxmd.com/read/27882941/tgf-%C3%AE-signaling-controls-fshr-signaling-reduced-ovarian-granulosa-cell-apoptosis-through-the-smad4-mir-143-axis
#9
Xing Du, Lifan Zhang, Xinyu Li, Zengxiang Pan, Honglin Liu, Qifa Li
Follicle-stimulating hormone receptor (FSHR) and its intracellular signaling control mammalian follicular development and female infertility. Our previous study showed that FSHR is downregulated during follicular atresia of porcine ovaries. However, its role and regulation in follicular atresia remain unclear. Here, we showed that FSHR knockdown induced porcine granulosa cell (pGC) apoptosis and follicular atresia, and attenuated the levels of intracellular signaling molecules such as PKA, AKT and p-AKT. FSHR was identified as a target of miR-143, a microRNA that was upregulated during porcine follicular atresia...
November 24, 2016: Cell Death & Disease
https://www.readbyqxmd.com/read/27870915/effects-of-angiopoietin-2-on-transplanted-mouse-ovarian-tissue
#10
Hye Won Youm, Jaewang Lee, Eun Jung Kim, Hyun Sun Kong, Jung Ryeol Lee, Chang Suk Suh, Seok Hyun Kim
Transplantation of ovarian tissue (OT) is currently the only clinical option to restore fertility with cryopreserved OT. However, follicle loss caused by ischemia and slow revascularization occurs in transplanted OT. To shorten the ischemic period and promote angiogenesis, some angiogenic factors have been used. Angiopoietin-2 (Ang2) is one of the major angiogenic factors and has been reported to promote blood vessels and increase vascular permeability in ischemic and/or hypoxic environment. This study was performed to investigate the effects of Ang2 on follicle integrity and revascularization of transplanted mouse OT...
2016: PloS One
https://www.readbyqxmd.com/read/27858152/effect-of-elevated-estradiol-levels-on-the-hcg-administration-day-on-ivf-pregnancy-and-birth-outcomes-in-the-long-gnrh-agonist-protocol-analysis-of-3393-cycles
#11
Meimei Wang, Cuifang Hao, Hongchu Bao, Xin Huang, Zhenteng Liu, Wei Zhang, Fenghua Li
INTRODUCTION: This retrospective study aimed to evaluate the association between elevated serum estradiol (E 2) levels on the human chorionic gonadotrophin (hCG) administration day and in vitro fertilization (IVF) pregnancy and birth outcomes in the long GnRH-agonist protocol. METHODS: This study analyzed the data of 3393 infertile women who underwent initial fresh IVF. The patients were categorized into high and low E 2 groups based on their serum E 2 levels on the hCG day...
November 17, 2016: Archives of Gynecology and Obstetrics
https://www.readbyqxmd.com/read/27852727/ovarian-tissue-culture-in-presence-of-vegf-and-fetuin-stimulates-follicle-growth-and-steroidogenesis
#12
Ebrahim Asadi, Atefeh Najafi, Ashraf Moeini, Reihaneh Pirjani, Gholamreza Hassanzadeh, Saideh Mikaeili, Ensieh Salehi, Emmanuel Adutwum, Mansoureh Soleimani, Fariba Khosravi, Mahmood Barati, Farid Abohassani
Ovarian tissue cryopreservation together with follicle culture provides a promising technique for fertility preservation in cancer patients. The study aimed to evaluate follicle parameters in a culture medium supplemented with VEGFA165 and/or fetuin. Vitrified-warmed ovarian cortical pieces were divided randomly into four culture groups consisting of basic culture medium (control), and the basic culture medium supplemented with VEGFA165, fetuin or both. After six days of culture, we evaluated the following: percentage of resting, primary and secondary growing follicles; survival rate; steroid hormones production; levels of reactive oxygen species, lipid peroxidation and total antioxidant capacity; and developmental and antioxidant gene expression...
November 16, 2016: Journal of Endocrinology
https://www.readbyqxmd.com/read/27852688/the-role-of-intracytoplasmic-sperm-injection-in-non-male-factor-infertility-in-advanced-maternal-age
#13
Samer Tannus, Weon-Young Son, Ashley Gilman, Grace Younes, Tal Shavit, Michael-Haim Dahan
STUDY QUESTION: Does ICSI improve reproductive outcomes compared with conventional IVF when used for non-male factor infertility in women aged 40 years and over? SUMMARY ANSWER: There is no advantage of ICSI over conventional IVF in women aged 40 years and over when used for non-male factor infertility. WHAT IS KNOWN ALREADY: The use of ICSI has increased dramatically in recent years and is being applied for indications other than male factor infertility...
November 16, 2016: Human Reproduction
https://www.readbyqxmd.com/read/27852101/human-chorionic-gonadotrophin-priming-for-fertility-treatment-with-in-vitro-maturation
#14
REVIEW
Jane Reavey, Katy Vincent, Timothy Child, Ingrid E Granne
BACKGROUND: In vitro maturation (IVM) is a fertility treatment that involves the transvaginal retrieval of immature oocytes, and their subsequent maturation and fertilisation. Although the live birth rate is lower than conventional in vitro fertilisation (IVF) with ovarian stimulation, it is a useful treatment, as it avoids the risk of ovarian hyperstimulation syndrome (OHSS). Women with polycystic ovaries (PCO) or polycystic ovarian syndrome (PCOS) are at an increased risk of OHSS. Thus, IVM may be a more useful treatment in this patient group...
November 16, 2016: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/27852097/subclinical-hypothyroidism-and-intracytoplasmic-sperm-injection-outcomes
#15
Marcela de Alencar Coelho Neto, Wellington de Paula Martins, Anderson Sanches de Melo, Rui Alberto Ferriani, Paula Andrea Navarro
Purpose Whether preconception elevated concentrations of thyroid-stimulating hormone (TSH) compromises reproductive outcomes in patients undergoing assisted reproduction techniques (ARTs) remains unclear. This study therefore compared the reproductive outcomes in patients with TSH concentrations of < 2.5 mIU/L, 2.5-4.0 mIU/L, and 4.0-10.0 mIU/L undergoing controlled ovarian stimulation (COS) for in vitro fertilization (IVF)/intracytoplasmic sperm injection (ICSI). Methods This retrospective cohort study evaluated the medical records of all women with measured TSH concentrations who underwent IVF/ICSI between January 2011 and December 2012...
November 16, 2016: Revista Brasileira de Ginecologia e Obstetrícia
https://www.readbyqxmd.com/read/27836468/outcomes-of-in-vitro-fertilization-cycles-among-patients-with-polycystic-ovary-syndrome-following-ovarian-puncture-for-in-vitro-maturation
#16
Jia Lin, Peiyu Wang, Junzhao Zhao, Shiquan Xiao, Rong Yu, Congcong Jin, Ruru Zhu
OBJECTIVE: To investigate the effects of ovarian puncture for in vitro maturation (IVM) on subsequent in vitro fertilization (IVF) embryo transfer cycles in patients with polycystic ovary syndrome (PCOS). METHODS: A retrospective study included data from patients admitted to the First Affiliated Hospital of Wenzhou Medical University, China, between January 1, 2008 and December 31, 2014. Patients with PCOS undergoing IVF cycles after having been treated with IVM unsuccessfully were included as the study group and an IVF-procedure data-matched control group of patients undergoing their first IVF cycles was included in a 1:4 ratio...
December 2016: International Journal of Gynaecology and Obstetrics
https://www.readbyqxmd.com/read/27831635/short-gonadotropin-releasing-hormone-agonist-versus-flexible-antagonist-versus-clomiphene-citrate-regimens-in-poor-responders-undergoing-in-vitro-fertilization-a-randomized-controlled-trial
#17
M Schimberni, F Ciardo, M Schimberni, A Giallonardo, V De Pratti, M Sbracia
OBJECTIVE: Poor responders represent a frustrating condition for couples undergoing IVF and clinicians, and their treatment remains disputed. To assess the efficacy and the most suitable protocol, we conducted a randomized controlled trial comparing three different protocols of ovarian stimulation in poor responder women: clomiphene citrate (CC) plus a high dose of gonadotropins and GnRH antagonist, flexible GnRH antagonist protocol and a short GnRH agonist protocol. PATIENTS AND METHODS: Between July 2014 and December 2015 we enrolled 250 poor responders in a previous IVF cycle at least 3 months before...
October 2016: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/27829021/plasma-ghrelin-concentrations-were-altered-with-oestrous-cycle-stage-and-increasing-age-in-reproductively-competent-wistar-females
#18
Michelle L Johnson, M Jill Saffrey, Victoria J Taylor
Changes in appetite occur during the ovarian cycle in female mammals. Research on appetite-regulatory gastrointestinal peptides in females is limited, because reproductive changes in steroid hormones present additional experimental factors to control for. This study aimed to explore possible changes in the orexigenic (appetite-stimulating) gastrointestinal peptide hormone ghrelin during the rodent oestrous cycle. Fed and fasted plasma and stomach tissue samples were taken from female Wistar rats (32-44 weeks of age) at each stage of the oestrous cycle for total ghrelin quantification using radioimmunoassay...
2016: PloS One
https://www.readbyqxmd.com/read/27825272/cost-effectiveness-of-letrozole-and-purified-urinary-fsh-in-treating-women-with-clomiphene-citrate-resistant-polycystic-ovarian-syndrome-a-randomized-controlled-trial
#19
AbdelGany Hassan, Nesreen Shehata, Amr Wahba
We aimed to compare the cost effectiveness of letrozole versus purified urinary follicle stimulating hormone (FSH) in treating patients with clomiphene citrate (CC)-resistant polycystic ovary syndrome (PCOS). This was a randomized trial conducted in Cairo University and Beni-Suef University Hospitals, Egypt. A cohort of 140 eligible women was randomized to receive either letrozole 2.5 mg twice daily for five days, or FSH using a graduated regimen starting with a dose of 75 IU. Treatment was repeated for three months if pregnancy did not occur...
November 8, 2016: Human Fertility: Journal of the British Fertility Society
https://www.readbyqxmd.com/read/27824942/identifying-maternal-constraints-on-fetal-growth-and-subsequent-perinatal-outcomes-using-a-multiple-embryo-implantation-model
#20
Nigel Pereira, Tyler Cozzubbo, Stephanie Cheung, Zev Rosenwaks, Gianpiero D Palermo, Queenie V Neri
INTRODUCTION: Although the majority of singleton births after in vitro fertilization (IVF) are uncomplicated, studies have suggested that IVF pregnancies may be independently associated with low birth weight (LBW), preterm birth (PTB), and perinatal mortality. These outcomes complicate multiple gestations as expected, but have also been reported in singletons. A multiple embryo implantation model allows for assessment of the early in utero environment, and therefore, assessment of any maternal constraints on developing fetuses...
2016: PloS One
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