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controlled ovarian stimulation

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https://www.readbyqxmd.com/read/29142445/a-study-of-controlled-ovarian-stimulation-with-clomiphene-citrate-or-letrozole-in-combination-with-gonadotropins-and-iui-in-unexplained-infertility
#1
Madhusmita Hembram, Ratna Biswas, Anju Jain
Aim: To compare the effect of clomiphene citrate (CC) + human menopausal gonadotropin (hMG) with letrozole + hMG on size, number of follicles, endometrial thickness, serum levels of oestradiol and progesterone and pregnancy rate. Settings and Design: Non-randomised interventional study. Patients and Methods: A total number of 60 patients in the age group of 20-35 years with unexplained infertility were divided into two groups, 30 in each. Group A received CC + hMG and group B received letrozole + hMG...
July 2017: Journal of Human Reproductive Sciences
https://www.readbyqxmd.com/read/29141508/anti-m%C3%A3-llerian-hormone-amh-may-stall-ovarian-cortex-function-through-modulation-of-hormone-receptors-other-than-the-amh-receptor
#2
Laura Detti, Nicole M Fletcher, Ghassan M Saed, Irene Peregrin-Alvarez, Rebecca A Uhlmann
OBJECTIVE: To test whether recombinant anti-Müllerian hormone (AMH) can inhibit ovarian cortex function by modulating the expression of other hormone receptors. MATERIALS AND METHODS: Pilot experimental study with ovarian cortex obtained from 5 patients. Immediately after explant, the ovarian cortex specimens were divided into 5 equal fragments. One fragment was flash-frozen (uncultured) and 4 were incubated for 48 hours at 37°C in a pH-adjusted gamete buffer medium with increasing AMH concentrations of 0, 5, 25, and 50 ng/mL...
January 1, 2017: Reproductive Sciences
https://www.readbyqxmd.com/read/29134695/acute-stimulation-of-a-smooth-muscle-constrictor-by-oestradiol-17%C3%AE-via-gper1-in-bovine-oviducts
#3
T Nishie, Y Kobayashi, K Kimura, K Okuda
Oviducts play roles in reproductive processes, including gametes transport, fertilization and early embryo development. Oviductal transport is controlled by various factors such as endothelins (EDNs) and nitric oxide (NO), smooth muscle contracting and relaxing factor, respectively. EDNs and NO production depend on an ovarian steroid hormone, oestradiol-17β (E2) and E2 quickly exerts their biological functions through G protein-coupled oestrogen receptor 1 (GPER1), which mediates rapid intracellular signalling...
November 14, 2017: Reproduction in Domestic Animals, Zuchthygiene
https://www.readbyqxmd.com/read/29133260/expression-of-fshr-in-chondrocytes-and-the-effect-of-fsh-on-chondrocytes
#4
Dehuan Kong, Qingbo Guan, Guandong Li, Wei Xin, Xiaoyi Qi, Yanjing Guo, Jiajun Zhao, Jin Xu, Shui Sun, Ling Gao
OBJECTIVE: Chondrocytes express many kinds of hormone receptors. The function of Follicle stimulating hormone (FSH) in the ovary is mediated by FSH receptor (FSHR). FSH receptor (FSHR) is found in many non-ovarian tissues, however it has been unclear if chondrocytes express FSHR. The purpose of this study is to determine it. METHODS: Mouse primary chondrocytes and human articular cartilage tissues were examined. The expression and sequence of FSHR mRNA by reverse transcription polymerase chain reaction (RT-PCR) and sequenced, respectively, and its protein expression was tested using western blotting and location was observed under immunofluorescence microscopy...
November 10, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29132339/sequential-e2-levels-not-ovarian-maximal-diameter-estimates-were-correlated-with-outcome-of-cetrotide-therapy-for-management-of-women-at-high-risk-of-ovarian-hyperstimulation-syndrome-a-randomized-controlled-study
#5
Khalid M Salama, Hesham M Abo Ragab, Mohammed F El Sherbiny, Ali A Morsi, Ibrahim I Souidan
BACKGROUND: Ovarian hyperstimulation syndrome (OHSS) is an important condition with considerable morbidity and a small risk of mortality and most commonly results as an iatrogenic condition following follicular stimulation of the ovaries. We aimed to evaluate safety and efficacy of 3-day cetrotide therapy started on day of oocyte retrieval (Day-0) in women at high-risk for development of ovarian hyperstimulation syndrome (OHSS) after GnRH agonist induction protocol. METHODS: Forty-eight women fulfilling inclusion criteria underwent ultrasound scanning for maximal ovarian diameter (MOD) estimation and ascites grading...
November 13, 2017: BMC Women's Health
https://www.readbyqxmd.com/read/29131262/mir-630-promotes-epithelial-ovarian-cancer-proliferation-and-invasion-via-targeting-klf6
#6
S Zhang, J-Y Zhang, L-J Lu, C-H Wang, L-H Wang
OBJECTIVE: MicroRNAs play critical roles in post-translational gene expression. The current study was to investigate the effects of miR-630 in epithelial ovarian cancer. PATIENTS AND METHODS: Thirty epithelial ovarian cancer tissue and thirty normal ovarian tissue samples were collected and were detected miR-630 expression level with qRT-PCR. MiR-630 mimics, inhibitors and negative controls were transfected into SKOV3 and Cell Counting Kit-8 (CCK-8) assay, and transwell experiment were performed to detect the proliferation rate and migration, respectively...
October 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29121269/individualized-versus-standard-fsh-dosing-in-women-starting-ivf-icsi-an-rct-part-2-the-predicted-hyper-responder
#7
Simone C Oudshoorn, Theodora C van Tilborg, Marinus J C Eijkemans, G Jur E Oosterhuis, Jaap Friederich, Marcel H A van Hooff, Evert J P van Santbrink, Egbert A Brinkhuis, Jesper M J Smeenk, Janet Kwee, Corry H de Koning, Henk Groen, Cornelis B Lambalk, Ben Willem J Mol, Frank J M Broekmans, Helen L Torrance
STUDY QUESTION: Does a reduced FSH dose in women with a predicted hyper response, apparent from a high antral follicle count (AFC), who are scheduled for IVF/ICSI lead to a different outcome with respect to cumulative live birth rate and safety? SUMMARY ANSWER: Although in women with a predicted hyper response (AFC > 15) undergoing IVF/ICSI a reduced FSH dose (100 IU per day) results in similar cumulative live birth rates and a lower occurrence of any grade of ovarian hyperstimulation syndrome (OHSS) as compared to a standard dose (150 IU/day), a higher first cycle cancellation rate and similar severe OHSS rate were observed...
November 7, 2017: Human Reproduction
https://www.readbyqxmd.com/read/29117655/genetic-etiology-of-primary-premature-ovarian-insufficiency
#8
Maja Franić-Ivanišević, Damir Franić, Miomira Ivović, Milina Tančić-Gajić, Ljiljana Marina, Marija Barac, Svetlana Vujović
Primary premature ovarian insufficiency (PPOI) is characterized by hypergonadotropic amenorrhea and hypoestrogenism in women under 40 years of age. PPOI incidence is 1:10,000 in women aged 18-25, 1:1000 in women aged 25-30 and 1:100 in women aged 35-40. In 10%-28% of cases, PPOI causes primary and in 4%-18% secondary amenorrhea. The process is a consequence of accelerated oocyte atresia, diminished number of germinated cells, and central nervous system aging. Specific genes are responsible for the control of oocyte number undergoing the ovulation process and the time to cessation of the reproductive function...
December 2016: Acta Clinica Croatica
https://www.readbyqxmd.com/read/29116933/first-line-antituberculosis-drugs-disrupt-endocrine-balance-and-induce-ovarian-and-uterine-oxidative-stress-in-rats
#9
Olayinka A Adebayo, Omolola A Adesanoye, Olalekan A Abolaji, Aderemi O Kehinde, Oluwatosin A Adaramoye
BACKGROUND: The first-line antituberculosis (anti-TB) drugs, isoniazid (INH), rifampicin (RIF), ethambutol (EMB), and pyrazinamide (PZA), are effective in the treatment of pulmonary tuberculosis. However, the toxicity of these drugs in the clinical setting limits their use. Here, we evaluated the effects of anti-TB drugs on the reproductive system in female rats. METHODS: Thirty-five female Wistar rats were assigned into five groups of seven animals each. The control group received normal saline, whereas others received INH (5 mg/kg), RIF (10 mg/kg), EMB (15 mg/kg), and PZA (15 mg/kg) through gavage thrice a week for 8 consecutive weeks...
November 8, 2017: Journal of Basic and Clinical Physiology and Pharmacology
https://www.readbyqxmd.com/read/29114912/silencing-pyruvate-kinase-nlpyk-leads-to-reduced-fecundity-in-brown-planthoppers-nilaparvata-lugens-st%C3%A3-l-hemiptera-delphacidae
#10
Lin-Quan Ge, Bo Huang, Xin Li, Hao-Tian Gu, Sui Zheng, Ze Zhou, Hong Miao, Jin-Cai Wu
Pyruvate kinase (PYK) operates in the glycolytic pathway, responsible for regulating the balance between glycolysis and gluconeogenesis. The previous work indicates PYK acts in development of Drosophila embryos and in embryonic muscle growth, from which it may be inferred that PYK acts in insect fecundity. More to the point, as a central enzyme in the glycolytic pathway, PYK acts in many energy-spending functions in most organisms. On the background findings that triazophos (TZP) stimulates fecundity via increase activities of several genes in brown planthoppers, Nilaparvata lugens, we investigated the combined influence of TZP and silencing a N...
November 7, 2017: Archives of Insect Biochemistry and Physiology
https://www.readbyqxmd.com/read/29111312/perinatal-outcomes-after-stimulated-versus-natural-cycle-ivf-a-systematic-review-and-meta-analysis
#11
REVIEW
Mohan Shashikant Kamath, Richard Kirubakaran, Mariano Mascarenhas, Sesh Kamal Sunkara
Pregnancies resulting from assisted reproductive techniques are at higher risk of adverse perinatal outcomes compared with spontaneous conceptions. Underlying infertility and IVF procedures have been linked to adverse perinatal outcomes. It is important to know if ovarian stimulation influences perinatal outcomes after IVF. A systematic search for relevant studies was conducted up to November 2016 on the following databases: PubMed, EMBASE, DARE and Cochrane Central Register of Controlled Trials. Perinatal outcomes included preterm birth (PTB), low birth weight (LBW), small for gestational age (SGA), large for gestational age (LGA) and congenital anomalies...
October 10, 2017: Reproductive Biomedicine Online
https://www.readbyqxmd.com/read/29105483/fsh-dose-to-stimulate-different-patient-ages-when-less-is-more
#12
Edson Borges, Bianca F Zanetti, Amanda S Setti, Daniela Paf Braga, Rita de Cássia S Figueira, Assumpto Iaconelli
OBJECTIVE: To determine the effect of FSH doses on intracytoplasmic sperm injection (ICSI) outcomes according to the age of the patient. METHODS: Patients undergoing controlled ovarian stimulation (COS) for ICSI cycles in a university-affiliated in vitro fertilization center were split into age groups: ≤35 y.o. (n=1523); >35 and ≤38 y.o. (n=652); >38 and ≤40 y.o. (n=332); and >40 y.o. (n=370). The effect of FSH dose on COS, laboratorial and clinical outomes was determined by linear regression models...
November 6, 2017: JBRA Assisted Reproduction
https://www.readbyqxmd.com/read/29105397/the-impact-of-genetic-variation-and-gene-expression-level-of-the-follicle-stimulating-hormone-receptor-on-ovarian-reserve
#13
Zeinab Ghezelayagh, Mehdi Totonchi, Shabnam Zarei-Moradi, Ommolbanin Asadpour, Saman Maroufizadeh, Poopak Eftekhari-Yazdi, Hamid Gourabi, Anahita Mohseni-Meybodi
OBJECTIVES: Ovarian reserve is defined as the capacity of the ovary to provide fertile oocytes. Diminished ovarian reserve (DOR) is a disorder in which ovaries are prone to go through early menopause. Where this loss of function occurs before the age of 40, it results in the premature ovarian failure (POF) disease. Throughout folliculogenesis, the follicle-stimulating hormone receptor (FSHR) starts a signaling cascade in the granulosa cells where its inactivation leads to the arrest of follicle maturation and therefore adversely affects ovarian reserve...
January 2018: Cell Journal
https://www.readbyqxmd.com/read/29096046/oral-medications-including-clomiphene-citrate-or-aromatase-inhibitors-with-gonadotropins-for-controlled-ovarian-stimulation-in-women-undergoing-in-vitro-fertilisation
#14
REVIEW
Mohan S Kamath, Abha Maheshwari, Siladitya Bhattacharya, Kar Yee Lor, Ahmed Gibreel
BACKGROUND: Gonadotropins are the most commonly used medications for controlled ovarian stimulation in in vitro fertilisation (IVF). However, they are expensive and invasive, and are associated with the risk of ovarian hyperstimulation syndrome (OHSS). Recent calls for more patient-friendly regimens have led to growing interest in the use of clomiphene citrate (CC) and aromatase inhibitors with or without gonadotropins to reduce the burden of hormonal injections. It is currently unknown whether regimens using CC or aromatase inhibitors such as letrozole (Ltz) are as effective as gonadotropins alone...
November 2, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29095972/placental-growth-factor-is-required-for-ovulation-luteinization-and-angiogenesis-in-primate-ovulatory-follicles
#15
Hannah R Bender, Heidi A Trau, Diane M Duffy
Placental growth factor (PGF) is member of the vascular endothelial growth factor (VEGF) family of angiogenesis regulators. VEGFA is an established regulator of ovulation and formation of the corpus luteum. To determine if PGF also mediates aspects of ovulation and luteinization, macaques received gonadotropins to stimulate multiple follicular development. Ovarian biopsies and whole ovaries were collected before (0h) and up to 36h after hCG administration to span the ovulatory interval. PGF and VEGFA were expressed by both granulosa cells and theca cells...
October 30, 2017: Endocrinology
https://www.readbyqxmd.com/read/29091146/how-polymorphic-markers-contribute-to-genetic-diseases-in-different-populations-the-study-of-inhibin-a-for-premature-ovarian-insufficiency
#16
Denise Maria Christofolini, Emerson Barchi Cordts, Fernando Santos-Pinheiro, Erika Azuma Kayaki, Mayla Cristina Fernandes Dornas, Monise de Castro Santos, Bianca Bianco, Caio Parente Barbosa
OBJECTIVE: To verify the incidence of the G679A mutation in exon 2 of the gene inhibin alpha (INHA), in women with secondary amenorrhea and diagnosis of premature ovarian insufficiency, and in controls. METHODS: A 5mL sample of peripheral blood was collected from all study participants in an EDTA tube and was used for DNA extraction. For the patient group, 5mL of blood were also collected in a tube containing heparin for karyotype, and 5mL were collected in a dry tube for follicle stimulant hormone dosage...
July 2017: Einstein
https://www.readbyqxmd.com/read/29082421/does-ovarian-reserve-affect-outcomes-in-single-ideal-blastocyst-transfers-in-women-less-than-40%C3%A2-years-of-age
#17
Andrew Zakhari, Senem Ates, Talya Shaulov, Michael H Dahan
PURPOSE: There is much debate whether diminished ovarian reserve is purely a quantitative issue, or if quality as determined by pregnancy potential of the ensuing oocytes is also affected. The purpose of this study was to determine whether diminished ovarian reserve, as established by one of three ways described below, affects pregnancy outcomes of women under 40 years old undergoing a single ideal blastocyst transfer. MATERIALS AND METHODS: This was a retrospective cohort study, including 507 women undergoing an ideal quality single embryo transfer between August 2010 and March 2014...
October 29, 2017: Archives of Gynecology and Obstetrics
https://www.readbyqxmd.com/read/29070088/effect-of-turmeric-on-the-viability-ovarian-folliculogenesis-fecundity-ovarian-hormones-and-response-to-luteinizing-hormone-of-rabbits
#18
A V Sirotkin, A Kadasi, A Stochmalova, A Balazi, M Földesiová, P Makovicky, P Chrenek, A H Harrath
The present study investigated whether dietary turmeric (Curcuma longa L.) can improve rabbit reproduction, ovarian function, growth, or viability. Female New Zealand White rabbits were either fed a standard diet (n=15) or a diet enriched with 5 g (group E1) or 20 g (group E2) turmeric powder per 100 kg feed mixture (n=16 or 15, respectively). After 295 days, weight gain, conception and kindling rates, pup and mother viability, ovarian macro- and micro-morphometric indices, release of leptin in response to the addition LH, and the release of progesterone, testosterone and leptin by isolated ovarian fragments were analyzed...
October 26, 2017: Animal: An International Journal of Animal Bioscience
https://www.readbyqxmd.com/read/29069987/in-vitro-fertilization-frozen-embryo-transfer-in-a-patient-with-cytochrome-p450-oxidoreductase-deficiency-a-case-report
#19
Tianran Song, Bin Wang, Huan Chen, Jingjing Zhu, Haixiang Sun
Cytochrome P450 enzymes are required for the synthesis of cholesterol and steroid hormones. Cytochrome P450 oxidoreductase (POR) donates electrons to microsomal cytochrome P450 enzymes. POR deficiency (PORD) is a rare autosomal recessive disease. In patients with PORD, steroid hormone synthesis is disrupted, which can cause infertility. The objective of this study was to report on a case of in vitro fertilization-frozen embryo transfer (IVF-FET) in a patient with PORD. The patient's hormone (i.e. 17α-hydroxyprogesterone) and electrolyte levels were within normal ranges ordinarily...
October 26, 2017: Gynecological Endocrinology
https://www.readbyqxmd.com/read/29068264/two-consecutive-successful-live-birth-in-woman-with-17%C3%AE-hydroxylase-deficiency-by-frozen-thaw-embryo-transfer-under-hormone-replacement-endometrium-preparation
#20
Michio Kitajima, Kiyonori Miura, Tsuneo Inoue, Yuko Murakami, Yuriko Kitajima, Naoko Murakami, Ken Taniguchi, Ko-Ichiro Yoshiura, Hideaki Masuzaki
17α-Hydroxylase deficiency is rare autosomal recessive disorder that manifested by hypertension, hypokalemia, delayed sexual development, primary amenorrhea and infertility. The information regarding infertility care and conception in women with this disorder are extremely limited. We report a 24-year-old Japanese woman with primary amenorrhea who was diagnosed as partial 17α-hydroxylase deficiency caused by homozygous 3 bp deletion in exon 1 of 17α-hydroxylase gene. In vitro fertilization with controlled ovarian stimulation was carried out and all viable embryo were frozen...
October 25, 2017: Gynecological Endocrinology
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