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https://www.readbyqxmd.com/read/29777718/malnutrition-is-associated-with-diminished-baseline-and-mycobacterial-antigen-stimulated-chemokine-responses-in-latent-tuberculosis-infection
#1
Rajamanickam Anuradha, Saravanan Munisankar, Yukthi Bhootra, Nathella Pavan Kumar, Chandrakumar Dolla, Subash Babu
OBJECTIVES: Previous studies have demonstrated a diminution in the baseline and mycobacterial antigen - specific cytokines in low body mass index (LBMI) individuals with latent tuberculosis infection (LTBI). We hypothesized that LBMI might be also associated with alteration in the baseline and antigen - stimulated levels of chemokines in LTBI. METHODS: To test this hypothesis, we examined baseline, TB- antigen and mitogen stimulated levels of chemokines in these individuals and compared them with those with LTBI and normal BMI (NBMI)...
May 16, 2018: Journal of Infection
https://www.readbyqxmd.com/read/29768180/dietary-fiber-confers-protection-against-flu-by-shaping-ly6c-patrolling-monocyte-hematopoiesis-and-cd8-t-cell-metabolism
#2
Aurélien Trompette, Eva S Gollwitzer, Céline Pattaroni, Isabel C Lopez-Mejia, Erika Riva, Julie Pernot, Niki Ubags, Lluis Fajas, Laurent P Nicod, Benjamin J Marsland
Dietary fiber protects against chronic inflammatory diseases by dampening immune responses through short-chain fatty acids (SCFAs). Here we examined the effect of dietary fiber in viral infection, where the anti-inflammatory properties of SCFAs in principle could prevent protective immunity. Instead, we found that fermentable dietary fiber increased survival of influenza-infected mice through two complementary mechanisms. High-fiber diet (HFD)-fed mice exhibited altered bone marrow hematopoiesis, characterized by enhanced generation of Ly6c- patrolling monocytes, which led to increased numbers of alternatively activated macrophages with a limited capacity to produce the chemokine CXCL1 in the airways...
May 15, 2018: Immunity
https://www.readbyqxmd.com/read/29762676/interleukin-38-is-a-protective-cytokine-for-lethal-sepsis
#3
Fang Xu, Shihui Lin, Xingxing Yan, Chuanjiang Wang, Hongmei Tu, Yibing Yin, Ju Cao
Background: IL-38 is the most recently characterized cytokine of the IL-1 family. However, its role in sepsis remains unknown. Methods: Circulating IL-38 was measured in two cohorts of adult and pediatric patients with sepsis. Using two murine models of lipopolysaccharide (LPS)-induced endotoxinemia and cecal ligation and puncture (CLP)-induced sepsis, the effects of IL-38 on survival, inflammation, tissue injury, or bacterial clearance were assessed. Results: Serum IL-38 concentrations were significantly elevated in adult and pediatric patients with sepsis relative to corresponding healthy adult and pediatric controls, respectively...
May 12, 2018: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/29760352/time-dependent-changes-in-local-and-serum-levels-of-inflammatory-cytokines-as-markers-for-incised-wound-aging-of-skeletal-muscles
#4
Mohammed Hassan Gaballah, Tetsuya Horita, Masataka Takamiya, Keisuke Yokoji, Mamiko Fukuta, Hideaki Kato, Yasuhiro Aoki
Wound age estimation is an important research field in forensic pathology. The expression levels of cytokines in the incised skeletal muscle were analyzed using a mouse model to explore the applicability for wound aging. A 5-mm long incisional wound was made at the biceps femoris muscle, and the muscle and serum were sampled at 6, 12, 24 and 48 hours after injury. Using a multiplex bead-based immunoassay, we measured the tissue levels of nine cytokines (IL-1β, IL-6, IL-7, CCL2, CCL3, CCL4, CXCL1, CXCL2, and CXCL10), which are all involved in the pathways of inflammatory response and tissue injury...
2018: Tohoku Journal of Experimental Medicine
https://www.readbyqxmd.com/read/29758231/infiltrating-macrophages-contribute-to-age-related-neuroinflammation-in-c57-bl6-mice
#5
H Wolfe, A M Minogue, S Rooney, M A Lynch
The recognized role of neuroinflammation in the age-related deterioration of neuronal function highlights the importance of understanding the factors that control microglial activation. Microglia, as the immune cells of the brain, are the arbiters of the inflammatory profile in the brain. Normally they are maintained in a quiescent state by means of ligand-receptor interactions with neurons, within a prevailing anti-inflammatory microenvironment. The evidence indicates that, as the ageing process continues, microglia become activated, shift towards an inflammatory phenotype and alter the milieu in the brain...
May 11, 2018: Mechanisms of Ageing and Development
https://www.readbyqxmd.com/read/29753311/peritoneal-and-systemic-responses-of-obese-type-ii-diabetic-rats-to-chronic-exposure-to-a-hyperbranched-polyglycerol-based-dialysis-solution
#6
Bo La Han, Qiunong Guan, Irina Chafeeva, Asher A Mendelson, Gerald da Roza, Richard Liggins, Jayachandran N Kizhakkedathu, Caigan Du
Metabolic syndrome (MetS) is commonly observed among peritoneal dialysis (PD) patients, and hyperbranched polyglycerol (HPG) is a promising glucose-sparing osmotic agent for PD. However, the biocompatibility of a HPG-based PD solution (HPG) in subjects with MetS has not been investigated. This study compared the local and systemic effects of a HPG solution with conventional Physioneal (PYS) and Icodextrin (ICO) PD solutions in rats with MetS. Obese type 2 diabetic ZSF1 rats received a daily intraperitoneal injection of PD solutions (10 mL) for 3 months...
May 12, 2018: Basic & Clinical Pharmacology & Toxicology
https://www.readbyqxmd.com/read/29749709/bacteria-induced-susceptibility-to-candida-albicans-superinfection-in-mice-via-monocyte-methyltransferase-setdb2
#7
Chen Xiao-Ping, Zheng Hao, Li Wen-Ge, Chen Guo-Dong, Lu Jin-Xing
Systemic bacterial infections are prone to secondary Candida albicans superinfection. However, the molecular mechanisms involved remain poorly understood. In this study, a model comprising sub-lethal cecal ligation and puncture (CLP) plus C. albicans intravenous injection (i.v.) was applied to mimic the situation in superinfection. Compared with mice without systemic bacterial infection, mice with systemic bacterial infection had lower anti-fungal gene expression (including Il1b, Tnf, Il6, Ifnb, Ifng, Cxcl1, and Ccr2) in monocytes, and less inflammatory monocytes and neutrophils infiltrating into the kidney when challenged with C...
May 11, 2018: Cellular Microbiology
https://www.readbyqxmd.com/read/29749505/identification-of-genes-and-pathways-associated-with-multiple-organ-dysfunction-syndrome-by-microarray-analysis
#8
Changwei Gu, Wanhai Qiao, Lina Wang, Minmin Li, Kang Song
Multiple organ dysfunction syndrome (MODS) is characterized by the development of progressive physiological dysfunction of ≥2 organs or organ systems and is responsible for the majority of the morbidity and mortality among patients in intensive care units. The aim of the present study was to investigate the potential genes and pathways associated with MODS. The microarray dataset GSE60088 was downloaded from the Gene Expression Omnibus and used to identify differentially expressed genes (DEGs) between organ tissues (lung, liver and kidney) obtained from a murine model of MODS and healthy controls...
May 4, 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29748248/bromodomain-protein-brd4-is-increased-in-human-placentas-from-women-with-early-onset-preeclampsia
#9
Stella Liong, Gillian Barker, Martha Lappas
Preeclampsia affects 5% of all pregnancies and is a serious disorder of pregnancy, characterised by high maternal blood pressure, placental hypoxia, fluid retention (oedema) and proteinuria. Women with preeclampsia are associated with exaggerated levels of pro-inflammatory cytokines, chemokines and anti-angiogenic factors such as soluble fms-like tyrosine kinase-1 (sFLT1). Studies in non-gestational tissues have described the bromodomain (BRD) and extraterminal family of proteins, in particular BRD4 to play a critical role in propagating inflammation and is currently a therapeutic target for treating cancer, lung inflammation and asthma...
June 2018: Reproduction: the Official Journal of the Society for the Study of Fertility
https://www.readbyqxmd.com/read/29744300/gene-expression-profiles-and-pathway-enrichment-analysis-of-human-osteosarcoma-cells-exposed-to-sorafenib
#10
Zhehao Dai, Haoyu Tang, Yue Pan, Junquan Chen, Yongping Li, Jun Zhu
Sorafenib is an inhibitor of a variety of tyrosine kinase receptors used to treat various cancers including hepatocellular, renal cell and thyroid carcinoma. It has been shown to change various targets associated with osteosarcoma, but the detailed mechanism remains unclear. In order to identify key genes, enriched pathways and important modules during the exposure of human osteosarcoma cells to sorafenib, data for gene expression profiles (http://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE53155) were downloaded from the GEO database...
May 2018: FEBS Open Bio
https://www.readbyqxmd.com/read/29733455/the-chemokine-fragment-cxcl9-74-103-diminishes-neutrophil-recruitment-and-joint-inflammation-in-antigen-induced-arthritis
#11
Daiane Boff, Helena Crijns, Rik Janssens, Vincent Vanheule, Gustavo B Menezes, Soraia Macari, Tarcilia A Silva, Flavio A Amaral, Paul Proost
This study investigates if treatment with a peptide corresponding to the 30 C-terminal amino acids of CXCL9, CXCL9(74-103), ameliorates joint inflammation in a murine model of antigen-induced arthritis (AIA). AIA was induced in male C57BL/6J mice. Intravenous injection of CXCL9(74-103), simultaneously performed with a tibiofemoral challenge with methylated BSA (mBSA) as antigen in mice immunized with mBSA, diminished the accumulation of leukocytes, in particular neutrophils, in the synovial cavity. The levels of the chemokines CXCL1, CXCL2, and CXCL6 and of the cytokine IL-6 were decreased in inflamed periarticular tissue of mice treated with the CXCL9-derived peptide compared to non-treated AIA mice...
May 7, 2018: Journal of Leukocyte Biology
https://www.readbyqxmd.com/read/29731776/potential-of-ipsc-derived-mesenchymal-stromal-cells-for-treating-periodontal-disease
#12
K Hynes, R Bright, V Marino, J Ng, P J Verma, S Gronthos, P M Bartold
Mesenchymal stromal cell-like populations have been derived from mouse-induced pluripotent stem cells (miPSC-MSC) with the capability for tissue regeneration. In this study, murine iPSC underwent differentiation towards an MSC-like immunophenotype. Stable miPSC-MSC cultures expressed the MSC-associated markers, CD73, CD105, and Sca-1, but lacked expression of the pluripotency marker, SSEA1, and hematopoietic markers, CD34 and CD45. Functionally, miPSC-MSC exhibited the potential for trilineage differentiation into osteoblasts, adipocytes, and chondrocytes and the capacity to suppress the proliferation of mitogen-activated splenocytes...
2018: Stem Cells International
https://www.readbyqxmd.com/read/29731737/lh-21-a-peripheral-cannabinoid-receptor-1-antagonist-exerts-favorable-metabolic-modulation-including-antihypertensive-effect-in-kkay-mice-by-regulating-inflammatory-cytokines-and-adipokines-on-adipose-tissue
#13
Ziqi Dong, Hui Gong, Yadan Chen, Hong Wu, Jun Wu, Yinghong Deng, Xinmao Song
Patients with obesity are susceptible to hypertension and diabetes. Over-activation of cannabinoid receptor 1 (CB1 R) in adipose tissue is proposed in the pathophysiology of metabolic disorders, which led to the metabolic dysfunction of adipose tissue and deregulated production and secretion of adipokines. In the current study, we determined the impact of LH-21, a representative peripheral CB1 R antagonist, on the obesity-accompanied hypertension and explored the modulatory action of LH-21 on the adipose tissue in genetically obese and diabetic KKAy mice...
2018: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/29728415/crispr-mediated-gene-editing-to-assess-the-roles-of-tet2-and-dnmt3a-in-clonal-hematopoiesis-and-cardiovascular-disease
#14
Soichi Sano, Kousei Ohshima, Ying Wang, Yasufumi Katanasaka, Miho Sano, Kenneth Walsh
<u>Rationale:</u> Clonal hematopoiesis has been associated with increased mortality and cardiovascular disease (CVD). This condition can arise from somatic mutations in pre-leukemic driver genes within hematopoietic stem/progenitor cells (HSPC). Approximately 40 candidate driver genes have been identified, but mutations in only one of these genes, Ten-Eleven Translocation-2 (TET2), has been shown to casually contribute to CVD in murine models. <u>Objective:</u> To develop a facile system to evaluate the disease characteristics of different clonal hematopoiesis driver genes using lentivirus vector and CRISPR/Cas9 methodology...
May 4, 2018: Circulation Research
https://www.readbyqxmd.com/read/29726306/secreted-giardia-intestinalis-cysteine-proteases-disrupt-intestinal-epithelial-cell-junctional-complexes-and-degrade-chemokines
#15
Jingyi Liu, Showgy Ma'ayeh, Dimitra Peirasmaki, Britta Lundström-Stadelmann, Lars Hellman, Staffan G Svärd
Giardiasis is a common diarrheal disease caused by the protozoan parasite Giardia intestinalis. Cysteine proteases (CPs) are acknowledged as virulence factors in Giardia but their specific role in the molecular pathogenesis of disease is not known. Herein, we aimed to characterize the three main secreted CPs (CP14019, CP16160 and CP16779), which were identified by mass spectrometry in the medium during interaction with intestinal epithelial cells (IECs) in vitro. First, the CPs were epitope-tagged and localized to the endoplasmic reticulum and cytoplasmic vesicle-like structures...
December 31, 2018: Virulence
https://www.readbyqxmd.com/read/29723192/the-are-binding-protein-tristetraprolin-ttp-is-a-novel-target-and-mediator-of-calcineurin-tumor-suppressing-function-in-the-skin
#16
Xunwei Wu, Alice Tommasi di Vignano, Qian Zhou, Piotr J Michel-Dziunycz, Fuxiang Bai, Jun Mi, Jing Qin, Tingjian Zu, Günther F L Hofbauer
An increased incidence of skin inflammatory diseases is frequently observed in organtransplanted patients being treated with calcineurin inhibitor-based immunosuppressive agents. The mechanism of increased skin inflammation in this context has however not yet been clarified. Here we report an increased inflammation following inhibition of calcineurin signaling seen in both chemically induced mouse skin tumors and in tumors grafted from H-rasV12 expressing primary human keratinocytes (HKCs). Following UVB or TPA treatment, we specifically found that deletion of the calcineurin gene in mouse keratinocytes (MKCs) resulted in increased inflammation, and this was accompanied by the enhanced production of pro-inflammatory cytokines, such as TNFα, IL-8 and CXCL1...
May 3, 2018: PLoS Genetics
https://www.readbyqxmd.com/read/29720975/matrix-remodeling-associated-7-deficiency-alleviates-carbon-tetrachloride-induced-acute-liver-injury-in-mice
#17
Dandan Lin, Zhenjiang Sun, Ziqi Jin, Lei Lei, Yonghao Liu, Bo Hu, Benfang Wang, Ying Shen, Yiqiang Wang
Matrix remodeling associated 7 (MXRA7) was first noted to co-express with a group of matrix remodeling related genes, and its biological functions had remained unclear. In this study, we investigated the presumed function of MXRA7 in a carbon tetrachloride (CCl4 )-induced acute liver injury model in mice. Wild-type, MXRA7-/- mice, and mice that were pulsed with hydrodynamic injection of vehicle or MXRA7-harboring plasmids were challenged with a single dose of CCl4 for injury induction. The sera, spleens, and livers were harvested from mice for assay of cytokines/chemokines expression, cellular responses, or histological features...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29719625/host-chemokine-signature-as-a-biomarker-for-the-detection-of-pre-cancerous-cervical-lesions
#18
Ramya Bhatia, Kim Kavanagh, June Stewart, Sharon Moncur, Itziar Serrano, Duanduan Cong, Heather A Cubie, Juergen G Haas, Camille Busby-Earle, Alistair R W Williams, Sarah E M Howie, Kate Cuschieri
Background: The ability to distinguish which hrHPV infections predispose to significant disease is ever more pressing as a result of the increasing move to hrHPV testing for primary cervical screening. A risk-stratifier or "triage" of infection should ideally be objective and suitable for automation given the scale of screening. Results: CCL2, CCL3, CCL4, CXCL1, CXCL8 and CXCL12 emerged as the strongest, candidate biomarkers to detect underlying disease [cervical intraepithelial neoplasia grade 2 or worse (CIN2+)]...
April 6, 2018: Oncotarget
https://www.readbyqxmd.com/read/29717936/different-effects-of-global-osteopontin-and-macrophage-osteopontin-in-glomerular-injury
#19
Jessica Trostel, Luan D Truong, Carlos A Roncal-Jimenez, Makoto Miyazaki, Shinobu Miyazaki-Anzai, Masanari Kuwabara, Rachel H McMahan, Ana Andres-Hernando, Yuka Sato, Thomas Jensen, Miguel A Lanaspa, Richard J Johnson, Gabriela E Garcia
Osteopontin (OPN) is a pro-and ant-inflammatory molecule that simultaneously attenuates oxidative stress. Both inflammation and oxidative stress play a role in the pathogenesis of glomerulonephritis and in the progression of kidney injury. Importantly, OPN is highly induced in nephritic kidney. To further characterize the role of OPN in kidney injury we used OPN-/- mice in anti-glomerular basement membrane reactive serum-induced immune nephritis (NTS), an inflammatory and progressive model of kidney disease...
May 2, 2018: American Journal of Physiology. Renal Physiology
https://www.readbyqxmd.com/read/29715366/differential-cxc-and-cx3c-chemokine-expression-profiles-in-aqueous-humor-of-patients-with-specific-endogenous-uveitic-entities
#20
Ahmed M Abu El-Asrar, Nele Berghmans, Saleh A Al-Obeidan, Priscilla W Gikandi, Ghislain Opdenakker, Jo Van Damme, Sofie Struyf
Purpose: To determine the levels of the neutrophil chemoattractants CXCL1, CXCL2, CXCL5, CXCL6, and CXCL8, the T helper 1 chemoattractants CXCL9, CXCL10 and CXCL11, the lymphoid chemokines CXCL12 and CXCL13 and the soluble form of the transmembrane chemokines CXCL16 and CX3CL1, in aqueous humor samples from patients with specific uveitic entities. Methods: Aqueous humor samples from patients with active uveitis associated with Behçet's disease (n = 13), sarcoidosis (n = 8), HLA-B27-related inflammation (n = 12), Vogt-Koyanagi-Harada (VKH) disease (n = 12), and healthy controls (n = 9) were assayed with the use of a multiplex assay...
May 1, 2018: Investigative Ophthalmology & Visual Science
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