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https://www.readbyqxmd.com/read/28922428/diminished-neutrophil-extracellular-trap-net-formation-is-a-novel-innate-immune-deficiency-induced-by-acute-ethanol-exposure-in-polymicrobial-sepsis-which-can-be-rescued-by-cxcl1
#1
Liliang Jin, Sanjay Batra, Samithamby Jeyaseelan
Polymicrobial sepsis is the result of an exaggerated host immune response to bacterial pathogens. Animal models and human studies demonstrate that acute alcohol intoxication is a key risk factor for sepsis-induced mortality. Multiple chemokines, such as CXCL1, CXCL2 and CXCL5 are critical for neutrophil recruitment and proper function of neutrophils. However, it is not quite clear the mechanisms by which acute alcohol suppresses immune responses and whether alcohol-induced immunosuppression can be rescued by chemokines...
September 18, 2017: PLoS Pathogens
https://www.readbyqxmd.com/read/28915246/inflammatory-cytokine-production-in-tumor-cells-upon-chemotherapy-drug-exposure-or-upon-selection-for-drug-resistance
#2
Derek W Edwardson, Justin Boudreau, Jonathan Mapletoft, Carita Lanner, A Thomas Kovala, Amadeo M Parissenti
Tumor Necrosis Factor alpha (TNF-α) has been shown to be released by tumor cells in response to docetaxel, and lipopolysaccharides (LPS), the latter through activation of toll-like receptor 4 (TLR4). However, it is unclear whether the former involves TLR4 receptor activation through direct binding of the drug to TLR4 at the cell surface. The current study was intended to better understand drug-induced TNF-α production in tumor cells, whether from short-term drug exposure or in cells selected for drug resistance...
2017: PloS One
https://www.readbyqxmd.com/read/28912380/exposure-of-neonatal-mice-to-bromine-impairs-their-alveolar-development-and-lung-function
#3
Tamas Jilling, Changchun Ren, Aaron Jefthy Yee, Saurabh Aggarwal, Brian Halloran, Namasivayam Ambalavanan, Sadis Matalon
The halogen bromine (Br2) is used extensively in industry and stored and transported in large quantities. Its accidental or malicious release into the atmosphere has resulted in significant casualties. The pathophysiology of Br2-induced lung injury has been studied in adult animals, but the consequences of Br2 exposure to the developing lung are completely unknown. We exposed neonatal mouse littermates on postnatal day 3 (P3) to either Br2 at 400 ppm for 30 minutes (400/30), to Br2 at 600 ppm for 30 minutes (600/30), or to room air, then returned them to their dams and observed until P14...
September 14, 2017: American Journal of Physiology. Lung Cellular and Molecular Physiology
https://www.readbyqxmd.com/read/28911210/a20-an-essential-component-of-the-ubiquitin-editing-protein-complex-is-a-negative-regulator-of-inflammation-in-human-myometrium-and-foetal-membranes
#4
Martha Lappas
STUDY QUESTION: Does A20 regulate mediators involved in the terminal processes of human labour in primary myometrial and amnion cells? SUMMARY ANSWER: A20 is a nuclear factor-kappa B (NF-κB) responsive gene that acts as a negative regulator of NF-κB-induced expression of pro-labour mediators. WHAT IS KNOWN ALREADY: Inflammation is commonly implicated in spontaneous preterm birth and the processes involved in rupture of foetal membranes and uterine contractions...
September 1, 2017: Molecular Human Reproduction
https://www.readbyqxmd.com/read/28902427/nlrp3-inflammasome-driven-liver-injury-and-fibrosis-roles-of-il-17-and-tnf
#5
Alexander Wree, Matthew D McGeough, Maria Eugenia Inzaugarat, Akiko Eguchi, Susanne Schuster, Casey D Johnson, Carla A Peña, Lukas J Geisler, Bettina G Papouchado, Hal M Hoffman, Ariel E Feldstein
The NLRP3 inflammasome, a caspase-1 activation platform plays a key role in the modulation of liver inflammation and fibrosis. Here, we tested the hypothesis that interleukin 17 (IL-17) and tumor necrosis factor (TNF) are key cytokines involved in amplifying and perpetuating the liver damage and fibrosis resulting from NLRP3 activation. To address this hypothesis gain of function Nlrp3(A350V) knock-in mice were bred onto il17a and Tnf knockout backgrounds allowing for constitutive Nlrp3 activation in myeloid derived cells in mice deficient in IL-17 or TNF...
September 13, 2017: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/28901435/differential-regulation-by-ifn%C3%A2-%C3%AE-on-tnf%C3%A2-%C3%AE-%C3%A2-induced-chemokine-expression-in-synovial-fibroblasts-from-temporomandibular-joint
#6
Kouji Ohta, Takako Naruse, Hiroki Kato, Yoko Ishida, Takayuki Nakagawa, Shigehiro Ono, Hideo Shigeishi, Masaaki Takechi
Tumor necrosis factor (TNF)‑α and interferon (IFN)‑γ, are inflammatory cytokines in the synovial fluid of patients with temporomandibular joint disorder (TMD). However, it remains unknown whether they participate in the regulation of various chemokine expression levels associated with TMD. The effects of TNF‑α and IFN‑γ on the expression of several different inflammatory chemokines, including interleukin (IL)‑8, C‑X‑C motif chemokine ligand (CXCL)1, C‑C motif chemokine ligand (CCL)20, CXCL9, CXCL10, and CXCL11 in synovial fibroblasts obtained from the temporomandibular joint (TMJ) were examined...
September 7, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28900389/cerebellar-atrophy-and-changes-in-cytokines-associated-with-the-cacna1a-r583q-mutation-in-a-russian-familial-hemiplegic-migraine-type-1-family
#7
Svetlana F Khaiboullina, Elena G Mendelevich, Leyla H Shigapova, Elena Shagimardanova, Guzel Gazizova, Alexey Nikitin, Ekaterina Martynova, Yuriy N Davidyuk, Enver I Bogdanov, Oleg Gusev, Arn M J M van den Maagdenberg, Rashid A Giniatullin, Albert A Rizvanov
Background: Immune mechanisms recently emerged as important contributors to migraine pathology with cytokines affecting neuronal excitation. Therefore, elucidating the profile of cytokines activated in various forms of migraine, including those with a known genetic cause, can help in diagnostic and therapeutic approaches. Methods: Here we (i) performed exome sequencing to identify the causal gene mutation and (ii) measured, using Bio-Plex technology, 22 cytokines in serum of patients with familial migraine (two with hemiplegic migraine and two with migraine with aura) from a Russian family that ethnically belongs to the Tatar population...
2017: Frontiers in Cellular Neuroscience
https://www.readbyqxmd.com/read/28895026/growth-arrest-specific-protein-7-regulates-the-murine-m1-alveolar-macrophage-polarization
#8
Qian Xu, Xiaofan Liu, Xinyuan Wang, Yuanqi Hua, Xiaoying Wang, Junli Chen, Jingyu Li, Yi Wang, Tobias Stoeger, Shanze Chen, Ning Huang
Growth arrest-specific gene 7 (Gas7) is preferentially expressed in terminally differentiated brain cells and plays a crucial role during neuronal development and neurite outgrowth. Apart from that, Gas7 was found to be abundantly expressed in immune cells like murine macrophage without knowing the actual roles in immune reaction. By using the Illumina microarray analysis, we observed a clear induction of Gas7 but no other Gas family members in murine M1-polarized alveolar macrophage, which was further confirmed by RT-qPCR, Western blotting, and immunostaining analysis, suggesting a likelihood that Gas7 may participate in murine alveolar macrophage polarization...
September 11, 2017: Immunologic Research
https://www.readbyqxmd.com/read/28886701/the-loss-of-function-disease-mutation-g301r-in-the-na-k-atpase-%C3%AE-2-isoform-decreases-lesion-volume-and-improves-functional-outcome-after-acute-spinal-cord-injury-in-mice
#9
Ditte Gry Ellman, Toke Jost Isaksen, Minna Christiansen Lund, Safinaz Dursun, Martin Wirenfeldt, Louise Helskov Jørgensen, Karin Lykke-Hartmann, Kate Lykke Lambertsen
BACKGROUND: The Na(+)/K(+)-ATPases are transmembrane ion pumps important for maintenance of ion gradients across the plasma membrane that serve to support multiple cellular functions, such as membrane potentials, regulation of cellular volume and pH, and co-transport of signaling transmitters in all animal cells. The α2Na(+)/K(+)-ATPase subunit isoform is predominantly expressed in astrocytes, which us the sharp Na(+)-gradient maintained by the sodium pump necessary for astroglial metabolism...
September 8, 2017: BMC Neuroscience
https://www.readbyqxmd.com/read/28884416/repeated-stress-exaggerates-lipopolysaccharide-induced-inflammatory-response-in-the-rat-spleen
#10
M Laukova, Peter Vargovic, I Rokytova, G Manz, R Kvetnansky
Spleen is an immune organ innervated with sympathetic nerves which together with adrenomedullary system control splenic immune functions. However, the mechanism by which prior stress exposure modulates the immune response induced by immunogenic challenge is not sufficiently clarified. Thus, the aim of this study was to investigate the effect of a single (2 h) and repeated (2 h daily for 7 days) immobilization stress (IMO) on the innate immune response in the spleen induced by lipopolysaccharide (LPS, 100 µg/kg)...
September 7, 2017: Cellular and Molecular Neurobiology
https://www.readbyqxmd.com/read/28881574/prevention-of-colitis-associated-cancer-by-selective-targeting-of-immunoproteasome-subunit-lmp7
#11
Niyati Vachharajani, Thorsten Joeris, Maik Luu, Sabrina Hartmann, Sabine Pautz, Elena Jenike, Georgios Pantazis, Immo Prinz, Markus J Hofer, Ulrich Steinhoff, Alexander Visekruna
Chronic inflammation is a well-known risk factor in development of intestinal tumorigenesis, although the exact mechanisms underlying development of colitis-associated cancer (CAC) still remain obscure. The activity and function of immunoproteasome has been extensively analyzed in the context of inflammation and infectious diseases. Here, we show that the proteasomal immunosubunit LMP7 plays an essential role in development of CAC. Mice devoid of LMP7 were resistant to chronic inflammation and formation of neoplasia, and developed virtually no tumors after AOM/DSS treatment...
August 1, 2017: Oncotarget
https://www.readbyqxmd.com/read/28881035/protease-activated-receptor-2-contributes-to-toxoplasma-gondii-mediated-gut-inflammation
#12
Chrystelle Bonnart, Guylène Feuillet, Virginie Vasseur, Nicolas Cenac, Nathalie Vergnolle, Nicolas Blanchard
Toxoplasma gondii is a widespread intracellular parasite, which naturally enters the organism via the oral route and cross the intestinal barrier to disseminate. In addition to neuronal and ocular pathologies, this pathogen also causes gut inflammation in a number of animals. This infection-triggered inflammation has been extensively studied in the C57BL/6 mice, highlighting the importance of the immune cells and their mediators in the development of gut pathology. However, despite their importance in inflammation, the role of Protease-Activated Receptors (PAR) was never reported in the context of T...
September 7, 2017: Parasite Immunology
https://www.readbyqxmd.com/read/28874800/mechanism-of-splenic-cell-death-and-host-mortality-in-a-plasmodium-yoelii-malaria-model
#13
Norinne Lacerda-Queiroz, Nicolas Riteau, Richard T Eastman, Kevin W Bock, Marlene S Orandle, Ian N Moore, Alan Sher, Carole A Long, Dragana Jankovic, Xin-Zhuan Su
Malaria is a fatal disease that displays a spectrum of symptoms and severity, which are determined by complex host-parasite interactions. It has been difficult to study the effects of parasite strains on disease severity in human infections, but the mechanisms leading to specific disease phenotypes can be investigated using strains of rodent malaria parasites that cause different disease symptoms in inbred mice. Using a unique mouse malaria model, here we investigated the mechanisms of splenic cell death and their relationship to control of parasitemia and host mortality...
September 5, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28874747/transcriptome-analysis-of-inflammation-related-gene-expression-in-endothelial-cells-activated-by-complement-masp-1
#14
Endre Schwaner, Zsuzsanna Németh, Péter K Jani, Erika Kajdácsi, Márta L Debreczeni, Zoltán Doleschall, József Dobó, Péter Gál, János Rigó, Kinga András, Tamás Hegedűs, László Cervenak
Mannan-binding lectin-associated serine protease 1 (MASP-1), the most abundant enzyme of the complement lectin pathway, is able to stimulate human umbilical vein endothelial cells (HUVECs) to alter the expression of several cytokines and adhesion molecules. This study has assessed to what extent MASP-1 is able to modify the transcriptional pattern of inflammation-related (IR) genes in HUVECs. We utilized Agilent microarray to analyse the effects of recombinant MASP-1 (rMASP-1) in HUVECs, on a set of 884 IR genes...
September 5, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28874093/comprehensive-dna-microarray-expression-profiles-of-tumors-in-tenascin-c-knockout-mice
#15
Kaori Matsumoto, Yuji Nakai, Masaru Hoshino, Koki Yamazaki, Yoshiaki Takioto, Satoru Takadera, Takayuki Nakagawa, Ryohei Nishimura, Moriaki Kusakabe
Tenascin-C (TNC), an extracellular matrix glycoprotein, plays a pivotal role in tumor growth. However, the mechanism whereby TNC affects tumor biology remains unclear. To investigate the exact role of TNC in primary tumor growth, a mouse mammary tumor cell line, GLMT1, was first developed. Subsequently, global gene expression in GLMT1-derived tumors was compared between wild-type (WT) and TNC-knockout (TNKO) mice. Tumors in WT mice were significantly larger than those in TNKO mice. DNA microarray analysis revealed 447 up and 667 downregulated in the tumors inoculated into TNKO mice as compared to tumors in WT mice...
September 6, 2017: Bioscience, Biotechnology, and Biochemistry
https://www.readbyqxmd.com/read/28871264/neuroinflammation-bone-marrow-stem-cells-and-chronic-pain
#16
REVIEW
Yul Huh, Ru-Rong Ji, Gang Chen
Current treatments for chronic pain, such as inflammatory pain, neuropathic pain, and cancer pain are insufficient and cause severe side effects. Mounting evidence suggests that neuroinflammation in the peripheral and central nervous system (PNS and CNS) plays a pivotal role in the genesis and maintenance of chronic pain. Characteristic features of neuroinflammation in chronic pain conditions include infiltration of immune cells into the PNS [e.g., the sciatic nerve and dorsal root ganglion (DRG)], activation of glial cells such as microglia and astrocytes in the CNS (spinal cord and brain), and production and secretion of pro-inflammatory cytokines and chemokines [TNF, interleukin (IL)-1β, IL-6, CCL2, and CXCL1]...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28870907/circulating-levels-of-vegf-and-cxcl1-are-predictive-of-metastatic-organotropismin-in-patients-with-colorectal-cancer
#17
Rosa Divella, Antonella Daniele, Raffaele DE Luca, Michele Simone, Emanuele Naglieri, Eufemia Savino, Ines Abbate, Cosmo Damiano Gadaleta, Girolamo Ranieri
Colorectal cancer is the most common cancer of the gastrointestinal system and has a marked preference to metastasize to distant organs. In this study, we investigated whether levels of circulating serum pro-angiogenic cytokine such as chemokine (C-X-C motif) ligand 1 (melanoma growth-stimulating activity, alpha; CXCL1) and vascular endothelial growth factor (VEGF) have a role in favoring the colonization of metastatic cells at preferential sites and determined their prognostic significance in a cohort of 103 patients with metastatic colorectal cancer...
September 2017: Anticancer Research
https://www.readbyqxmd.com/read/28869519/differences-in-sulfotyrosine-binding-amongst-cxcr1-and-cxcr2-chemokine-ligands
#18
Natasha A Moussouras, Anthony E Getschman, Emily R Lackner, Christopher T Veldkamp, Michael B Dwinell, Brian F Volkman
Tyrosine sulfation, a post-translational modification found on many chemokine receptors, typically increases receptor affinity for the chemokine ligand. A previous bioinformatics analysis suggested that a sulfotyrosine (sY)-binding site on the surface of the chemokine CXCL12 may be conserved throughout the chemokine family. However, the extent to which receptor tyrosine sulfation contributes to chemokine binding has been examined in only a few instances. Computational solvent mapping correctly identified the conserved sulfotyrosine-binding sites on CXCL12 and CCL21 detected by nuclear magnetic resonance (NMR) spectroscopy, demonstrating its utility for hot spot analysis in the chemokine family...
September 3, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28862768/airway-remodelling-and-inflammation-in-asthma-are-dependent-on-the-extracellular-matrix-protein-fibulin-1c
#19
Gang Liu, Marion A Cooley, Prema M Nair, Chantal Donovan, Alan C Hsu, Andrew G Jarnicki, Tatt Jhong Haw, Nicole G Hansbro, Qi Ge, Alexandra C Brown, Hock Tay, Paul S Foster, Peter A Wark, Jay C Horvat, Jane E Bourke, Chris L Grainge, W Scott Argraves, Brian G Oliver, Darryl A Knight, Janette K Burgess, Philip M Hansbro
Asthma is a chronic inflammatory disease of the airways. It is characterised by allergic airway inflammation, remodelling and hyperresponsiveness (AHR). Asthma patients, in particular those with chronic or severe asthma, have airway remodelling that is associated with the accumulation of extracellular matrix (ECM) proteins, such as collagens. Fibulin-1 (Fbln1) is an important ECM protein that stabilises collagen and other ECM proteins. Fbln1c, one of the four Fbln1 variants, which predominates in both humans and mice, is increased in the serum and airways fluids in asthma but its function is unclear...
September 1, 2017: Journal of Pathology
https://www.readbyqxmd.com/read/28860501/in-vivo-immune-interactions-of-multipotent-stromal-cells-underlie-their-long-lasting-pain-relieving-effect
#20
Wei Guo, Satoshi Imai, Jia-Le Yang, Shiping Zou, Mineo Watanabe, Yu-Xia Chu, Zaid Mohammad, Huakun Xu, Kamal D Moudgil, Feng Wei, Ronald Dubner, Ke Ren
Systemic infusion of bone marrow stromal cells (BMSCs), a major type of multipotent stromal cells, produces pain relief (antihyperalgesia) that lasts for months. However, studies have shown that the majority of BMSCs are trapped in the lungs immediately after intravenous infusion and their survival time in the host is inconsistent with their lengthy antihyperalgesia. Here we show that long-lasting antihyperalgesia produced by BMSCs required their chemotactic factors such as CCL4 and CCR2, the integrations with the monocytes/macrophages population, and BMSC-induced monocyte CXCL1...
August 31, 2017: Scientific Reports
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