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https://www.readbyqxmd.com/read/28528204/a-novel-pleiotropic-effect-of-aspirin-beneficial-regulation-of-pro-and-anti-inflammatory-mechanisms-in-microglial-cells
#1
Diana Kata, Imre Földesi, Liliana Z Feher, Laszlo Hackler, Laszlo G Puskas, Karoly Gulya
Aspirin, one of the most widely used non-steroidal anti-inflammatory drugs, has extensively studied effects on the cardiovascular system. To reveal further pleiotropic, beneficial effects of aspirin on a number of pro- and anti-inflammatory microglial mechanisms, we performed morphometric and functional studies relating to phagocytosis, pro- and anti-inflammatory cytokine production (IL-1β, tumor necrosis factor-α (TNF-α) and IL-10, respectively) and analyzed the expression of a number of inflammation-related genes, including those related to the above functions, in pure microglial cells...
May 17, 2017: Brain Research Bulletin
https://www.readbyqxmd.com/read/28528167/cxcl1-inhibition-regulates-uvb-induced-skin-inflammation-and-tumorigenesis-in-xpa-deficient-mice
#2
Makoto Kunisada, Chieko Hosaka, Chihiro Takemori, Eiji Nakano, Chikako Nishigori
Xeroderma pigmentosum complementation group A (XP-A) is a hereditary disease characterized by early onset of skin cancers and freckles-like pigmented maculae in the sun-exposed sites. Although etiology of predisposition to UV-induced skin tumors in XP-A is well investigated as a repair deficiency in UV-induced DNA damage, the mechanism of exaggerated sunburn in patients with XP-A and whether UV-induced inflammation relates to skin tumor-prone phenotype remains to be elucidated. Using gene profiling of XP-A model mice, Xpa-deficient mice, we found that expression of CXCL1 in the skin and blood levels of in Xpa-deficient mice increased significantly after UVB exposure at an even a limited area in comparison to those of wild-type mice...
May 17, 2017: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/28523567/peripheral-viral-challenge-triggers-hippocampal-production-of-inflammatory-proteins
#3
Tiffany Petrisko, Gregory Konat
Peripheral viral infections increase seizure propensity and intensity in susceptible individuals. We have modeled this comorbidity by demonstrating that intraperitoneal (ip) injection of the conventional viral mimetic, polyinosinic-polycytidylic acid (PIC), renders the brain hypersusceptible to seizures induced by kainic acid (KA). At the molecular level, the hippocampus, which is the ictal site of KA-induced seizures, exhibits upregulated expression of messages encoding several inflammatory genes. Here, we profiled temporal expression of these genes at the protein level...
May 18, 2017: Metabolic Brain Disease
https://www.readbyqxmd.com/read/28518141/caf-secreted-cxcl1-conferred-radioresistance-by-regulating-dna-damage-response-in-a-ros-dependent-manner-in-esophageal-squamous-cell-carcinoma
#4
Hongfang Zhang, Jing Yue, Zhenzhen Jiang, Rongjing Zhou, Ruifei Xie, Yiping Xu, Shixiu Wu
Five-year survival rate of esophageal squamous cell carcinoma (ESCC) patients treated with radiotherapy is <20%. Our study aimed to investigate whether cancer-associated fibroblasts (CAFs), one major component of tumor microenvironment, were involved in tumor radioresistance in ESCC. By use of human chemokine/cytokine array, human chemokine CXCL1 was found to be highly expressed in CAFs compared with that in matched normal fibroblasts. Inhibition of CXCL1 expression in CAFs significantly reversed CAF-conferred radioresistance in vitro and in vivo...
May 18, 2017: Cell Death & Disease
https://www.readbyqxmd.com/read/28516946/ccl2-ccr2-signalling-recruits-a-distinct-fetal-microchimeric-population-that-rescues-delayed-maternal-wound-healing
#5
Mathieu Castela, Dany Nassar, Maria Sbeih, Marie Jachiet, Zhe Wang, Selim Aractingi
Foetal microchimeric cells (FMCs) traffic into maternal circulation during pregnancy and persist for decades after delivery. Upon maternal injury, FMCs migrate to affected sites where they participate in tissue healing. However, the specific signals regulating the trafficking of FMCs to injury sites had to be identified. Here we report that, in mice, a subset of FMCs implicated in tissue repair displays CD11b(+) CD34(+) CD31(+) phenotype and highly express C-C chemokine receptor 2 (Ccr2). The Ccr2 ligand chemokine ligand 2 (Ccl2) enhances the recruitment of FMCs to maternal wounds where these cells transdifferentiate into endothelial cells and stimulate angiogenesis through Cxcl1 secretion...
May 18, 2017: Nature Communications
https://www.readbyqxmd.com/read/28514506/human-adipose-derived-mesenchymal-stem-cell-secreted-cxcl1-and-cxcl8-facilitate-breast-tumor-growth-by-promoting-angiogenesis
#6
Yuan Wang, Junli Liu, Qingyuan Jiang, Jie Deng, Fen Xu, Xiaolei Chen, Fuyi Cheng, Yujing Zhang, Yunqi Yao, Zhemin Xia, Xia Xu, Xiaolan Su, Meijuan Huang, Lei Dai, Yang Yang, Shuang Zhang, Dechao Yu, Robert Chunhua Zhao, Yuquan Wei, Hongxin Deng
Autologous adipose tissue or adipose tissue with additive adipose-derived mesenchymal stem cells (ADSCs) is used in the breast reconstruction of breast cancer patients who undergo mastectomy. ADSCs play an important role in the angiogenesis and adipogenesis, which make it much better than other materials. However, ADSCs may promote residual tumor cells to proliferate or metastasize, and the mechanism is still not fully understood. In our present study, we demonstrated that hADSCs could facilitate tumor cells growth after co-injection with MCF7 and ZR-75-30 breast cancer cells (BCCs) by promoting angiogenesis, but hADSCs showed limited effect on the growth of MDA-MB-231 BCCs...
May 17, 2017: Stem Cells
https://www.readbyqxmd.com/read/28491039/daily-moderate-exercise-is-beneficial-and-social-stress-is-detrimental-to-disease-pathology-in-murine-lupus-nephritis
#7
Saba I Aqel, Jeffrey M Hampton, Michael Bruss, Kendra T Jones, Giancarlo R Valiente, Lai-Chu Wu, Matthew C Young, William L Willis, Stacy Ardoin, Sudha Agarwal, Brad Bolon, Nicole Powell, John Sheridan, Naomi Schlesinger, Wael N Jarjour, Nicholas A Young
Daily moderate exercise (DME) and stress management are underemphasized in the care of patients with lupus nephritis (LN) due to a poor comprehensive understanding of their potential roles in controlling the inflammatory response. To investigate these effects on murine LN, disease progression was monitored with either DME or social disruption stress (SDR) induction in NZM2410/J mice, which spontaneously develop severe, early-onset LN. SDR of previously established social hierarchies was performed daily for 6 days and DME consisted of treadmill walking (8...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/28484277/tyrosine-kinase-inhibitors-of-ripk2-attenuate-bacterial-cell-wall-mediated-lipolysis-inflammation-and-dysglycemia
#8
Brittany M Duggan, Kevin P Foley, Brandyn D Henriksbo, Joseph F Cavallari, Akhilesh K Tamrakar, Jonathan D Schertzer
Inflammation underpins aspects of insulin resistance and dysglycemia. Microbiota-derived cell wall components such as muropeptides or endotoxin can trigger changes in host immunity and metabolism. Specific peptidoglycan motifs promote metabolic tissue inflammation, lipolysis and insulin resistance via Nucleotide-binding oligomerization domain-containing protein 1 (Nod1). Receptor-interacting serine/threonine-protein kinase 2 (Ripk2) mediates Nod1-induced immunity, but the role of Ripk2 in metabolism is ill-defined...
May 8, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28483607/interleukin-17a-promotes-lung-tumor-progression-through-neutrophil-attraction-to-tumor-sites-and-mediating-resistance-to-pd-1-blockade
#9
Esra A Akbay, Shohei Koyama, Yan Liu, Ruben Dries, Lauren E Bufe, Michael Silkes, Md Maksudul Alam, Dillon M Magee, Robert Jones, Masahisa Jinushi, Meghana Kulkarni, Julian Carretero, Xiaoen Wang, Tiquella Warner-Hatten, Jillian D Cavanaugh, Akio Osa, Atsushi Kumanogoh, Gordon J Freeman, Mark M Awad, David C Christiani, Raphael Bueno, Peter S Hammerman, Glenn Dranoff, Kwok-Kin Wong
HYPOTHESIS: Proinflammatory cytokine Interleukin (IL)-17A (IL-17A) is overexpressed in a subset of patients with lung cancer. We hypothesized that IL-17A promotes a pro-tumorigenic inflammatory phenotype, and inhibits anti-tumor immune responses. EXPERIMENTAL DESIGN: We generated bi-transgenic mice expressing a conditional IL-17A allele along with conditional Kras(G12D) and performed immune phenotyping of mouse lungs, survival analysis, and treatment studies with antibodies either blocking PD-1 or IL6, or depleting neutrophils...
May 5, 2017: Journal of Thoracic Oncology
https://www.readbyqxmd.com/read/28481289/interleukin-17a-promotes-lymphocytes-adhesion-and-induces-ccl2-and-cxcl1-release-from-brain-endothelial-cells
#10
Dagmara Weronika Wojkowska, Piotr Szpakowski, Andrzej Glabinski
The nature of the interaction between Th17 cells and the blood-brain barrier (BBB) is critical for the development of autoimmune inflammation in the central nervous system (CNS). Tumor necrosis factor alpha (TNF-α) or interleukin 17 (IL-17) stimulation is known to enhance the adherence of Th17 cells to the brain endothelium. The brain endothelial cells (bEnd.3) express Vascular cell adhesion molecule 1 (VCAM-1), the receptor responsible for inflammatory cell adhesion, which binds very late antigen 4 (VLA-4) on migrating effector lymphocytes at the early stage of brain inflammation...
May 8, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28479263/novel-rodent-model-of-breast-cancer-survival-with-persistent-anxiety-like-behavior-and-inflammation
#11
Leah M Pyter, Lorena P Suarez-Kelly, William E Carson, Jasskiran Kaur, Joshua Bellasario, Savannah R Bever
Breast cancer survivors are an expanding population that is troubled by lasting mental health problems, including depression and anxiety. These issues reduce quality-of-life throughout survivorhood. Research indicates that tumor biology, cancer treatments, and stress contribute to these mood disturbances. Although the mechanisms underlying these various causes remain under investigation, neuroinflammation is a leading hypothesis. To date, rodent models of recurrence-free tumor survival for understanding mechanisms by which these behavioral issues persist after cancer are lacking...
May 4, 2017: Behavioural Brain Research
https://www.readbyqxmd.com/read/28473630/epidermal-growth-factor-receptor-inhibition-downregulates-helicobacter-pylori-induced-epithelial-inflammatory-responses-dna-damage-and-gastric-carcinogenesis
#12
Johanna C Sierra, Mohammad Asim, Thomas G Verriere, M Blanca Piazuelo, Giovanni Suarez, Judith Romero-Gallo, Alberto G Delgado, Lydia E Wroblewski, Daniel P Barry, Richard M Peek, Alain P Gobert, Keith T Wilson
OBJECTIVE: Gastric cancer is the third leading cause of cancer death worldwide and infection by Helicobacter pylori is the strongest risk factor. We have reported increased epidermal growth factor receptor (EGFR) phosphorylation in the H. pylori-induced human carcinogenesis cascade, and association with DNA damage. Our goal was to determine the role of EGFR activation in gastric carcinogenesis. DESIGN: We evaluated gefitinib, a specific EGFR inhibitor, in chemoprevention of H...
May 4, 2017: Gut
https://www.readbyqxmd.com/read/28462384/trif-differentially-regulates-hepatic-steatosis-and-inflammation-fibrosis-in-mice
#13
Ling Yang, Kouichi Miura, Bi Zhang, Hiroshi Matsushita, Yoon Mee Yang, Shuang Liang, Jingyi Song, Yoon Seok Roh, Ekihiro Seki
BACKGROUND & AIMS: Toll-like receptor 4 (TLR4) signaling is activated through 2 adaptor proteins: MyD88 and TIR-domain containing adaptor-inducing interferon-β (TRIF). TLR4 and MyD88 are crucial in nonalcoholic steatohepatitis (NASH) and fibrosis. However, the role of TRIF in TLR4-mediated NASH and fibrosis has been elusive. This study investigated the differential roles of TRIF in hepatic steatosis and inflammation/fibrosis. METHODS: A choline-deficient amino acid defined (CDAA) diet was used for the mouse NASH model...
May 2017: Cellular and Molecular Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28455419/cxcl1-is-critical-for-pre-metastatic-niche-formation-and-metastasis-in-colorectal-cancer
#14
Dingzhi Wang, Haiyan Sun, Jie Wei, Bo Cen, Raymond N DuBois
Emerging evidence suggests that the primary tumor influences the development of supportive metastatic microenvironments, referred to as pre-metastatic niches, in certain distant organs before arrival of metastatic cells.  However, the mechanisms underlying the contributions of the primary tumor to pre-metastatic niche formation are not fully understood.  Here we demonstrate that colorectal carcinoma cells secrete VEGF-A, which stimulates tumor-associated macrophages to produce CXCL1 in the primary tumor.  Elevation of CXCL1 in pre-metastatic liver tissue recruited CXCR2-positive myeloid-derived suppressor cells (MDSC) to form a pre-metastatic niche that ultimately promoted liver metastases...
April 28, 2017: Cancer Research
https://www.readbyqxmd.com/read/28448869/immunomodulatory-activities-of-phlorizin-metabolites-in-lipopolysaccharide-stimulated-raw264-7-cells
#15
Ya Zhao, ChunPing Liu, XiaoPing Lai, ShaoZhen Hou, Xing Zeng, Xiong Li
The immunomodulatory effects of two new phlorizin metabolites, phloretin 4-O-β-d-glucuronide (1), 6-methoxyl-phloretin-2-O-β-d-glucuronide (2), together with phloretin-2-O-β-d-glucuronide (3) on lipopolysaccharide (LPS)-stimulated RAW 264.7 macrophage cells were determined. 1-3 (1-5μg/ml) significantly inhibited the production of NO (p<0.01). At the concentration of 5μg/ml, 2 and 3 further inhibited iNOS mRNA expression (p<0.01 or 0.05), and 1-3 inhibited iNOS protein expression (p<0.01). Conversely, they all promoted the proinflammatory cytokine TNF-α mRNA expression (p<0...
April 24, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28446981/role-of-cxc-group-chemokines-in-lung-cancer-development-and-progression
#16
Artjoms Spaks
BACKGROUND: Clinical and translational research on lung cancer patients undergoing surgical treatment can provide valuable scientific data and unique opportunity to study tumor microenvironment. CXC chemokines, which are members of a big family of cytokines, are undoubtedly involved in tumor growth regulation and metastasizing pathways. For better understanding of CXC chemokine involvement in the process of carcinogenesis we have studied the cohort of early stage non-small cell lung cancer patients undergoing surgery with curative intent...
April 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/28440025/identifying-key-genes-in-rheumatoid-arthritis-by-weighted-gene-co-expression-network-analysis
#17
Chunhui Ma, Qi Lv, Songsong Teng, Yinxian Yu, Kerun Niu, Chengqin Yi
PURPOSE: This study aimed to identify rheumatoid arthritis (RA) related genes based on microarray data using the WGCNA (weighted gene co-expression network analysis) method. METHODS: Two gene expression profile datasets GSE55235 (10 RA samples and 10 healthy controls) and GSE77298 (16 RA samples and seven healthy controls) were downloaded from Gene Expression Omnibus database. Characteristic genes were identified using metaDE package. WGCNA was used to find disease-related networks based on gene expression correlation coefficients, and module significance was defined as the average gene significance of all genes used to assess the correlation between the module and RA status...
April 25, 2017: International Journal of Rheumatic Diseases
https://www.readbyqxmd.com/read/28438165/microglia-derived-il-1%C3%AE-promotes-chemokine-expression-by-m%C3%A3-ller-cells-and-rpe-in-focal-retinal-degeneration
#18
Riccardo Natoli, Nilisha Fernando, Michele Madigan, Joshua A Chu-Tan, Krisztina Valter, Jan Provis, Matt Rutar
BACKGROUND: Chemokine signalling is required for the homing of leukocytes during retinal inflammation, and is associated with pathogenesis of diseases such as age-related macular degeneration (AMD). Here, we explore the role of interleukin-1β (IL-1β) in modulating AMD-associated chemokines Ccl2, Cxcl1, and Cxcl10 during photo-oxidative retinal damage, and the effect on both the accumulation of outer-retinal macrophages, and death of photoreceptors. METHODS: Inhibition of retinal IL-1β expression was performed using either siRNA or antibody neutralisation, which was intravitreally injected in SD rats prior to photo-oxidative damage...
April 24, 2017: Molecular Neurodegeneration
https://www.readbyqxmd.com/read/28437540/characterization-of-gene-expression-phenotype-in-amyotrophic-lateral-sclerosis-monocytes
#19
Weihua Zhao, David R Beers, Kristopher G Hooten, Douglas H Sieglaff, Aijun Zhang, Shanker Kalyana-Sundaram, Christopher M Traini, Wendy S Halsey, Ashley M Hughes, Ganesh M Sathe, George P Livi, Guo-Huang Fan, Stanley H Appel
Importance: Amyotrophic lateral sclerosis (ALS) is a common adult-onset neurodegenerative disease characterized by selective loss of upper and lower motor neurons. Patients with ALS have persistent peripheral and central inflammatory responses including abnormally functioning T cells and activated microglia. However, much less is known about the inflammatory gene profile of circulating innate immune monocytes in these patients. Objective: To characterize the transcriptomics of peripheral monocytes in patients with ALS...
April 24, 2017: JAMA Neurology
https://www.readbyqxmd.com/read/28425867/chemokines-and-relevant-micrornas-in-the-atherogenic-process
#20
Dimitry A Chistiakov, Alexander N Orekhov, Yuri V Bobryshev
Chemokines play a significant role in initial and advanced steps of atherogenesis. In early steps, chemokines control the adhesion of leukocytes to endothelial cells (ECs) followed by transmigration of monocytes and their deposition in the intima where they differentiate to proinflammatory macrophages. Except proinflammatory activity, chemokines are responsible for homeostasis and homing of progenitor cells. Recently, microRNAs (miRs) were found to control expression and activity of chemokines in ECs, vascular smooth muscle cells (VSMCs), and macrophages at different steps of atherogenesis...
April 19, 2017: Mini Reviews in Medicinal Chemistry
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