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China infant

Liru Qiu, Fengjie Yang, Yonghua He, Huiqing Yuan, Jianhua Zhou
Cystic fibrosis (CF) is a fatal autosomal-recessive disease caused by mutations in the CF transmembrane conductance regulator (CFTR) gene. CF is characterized by recurrent pulmonary infection with obstructive pulmonary disease. CF is common in the Caucasian population but is rare in the Chinese population. The symptoms of early-stage CF are often untypical and may sometimes manifest as Bartter syndrome (BS)-like hypokalemic alkalosis. Therefore, the ability of doctors to differentiate CF from BS-like hypokalemic alkalosis in Chinese infants is a great challenge in the timely and accurate diagnosis of CF...
March 9, 2018: Frontiers of Medicine
Yongming Zhou, Jingyun Zhang, Shukun Wang, Wen Xu, Weili Liang, Meiying Yan, Duochun Wang, Baowei Diao, Bo Pang, Xin Lu, Fenxia Fan, Jie Li, Jing Lou, Li Zhang, Ruibai Wang, Xiaoying Cui, Meng Zhao, Rui Wu, Hongyan Cai, Xiaoli Du, Zhigang Cui, Wenpeng Gu, Rusong Yang, Biao Kan
OBJECTIVES: To conduct a one-year pathogen surveillance of acute diarrheal disease based on outpatient clinics in township hospitals in rural Hongta District of Yunnan Province, China. METHODS: Fecal specimens of acute diarrhea cases and relevant epidemiological information were collected. Salmonella, Shigella, Vibrio, Aeromonas, Plesiomonas shigelloides and diarrheogenic Escherichia coli (DEC) were examined. RESULTS: Among the 797 stool specimens sampled, 198 samples (24...
March 5, 2018: International Journal of Infectious Diseases: IJID
Songxu Peng, Zhihua Wan, Tingting Liu, Huiping Zhu, Yukai Du
GOALS: To identify the potential risk factors of hepatitis B virus (HBV) intrauterine transmission and predict the incidence of HBV intrauterine transmission among hepatitis B surface antigen-positive pregnant women with diverse viral load. BACKGROUND: The intrauterine transmission of HBV significantly contributes to the persistence of a high number of patients infected with HBV. However, its risk factors remain unclear. MATERIALS AND METHODS: A prospective study was performed on hepatitis B surface antigen-positive pregnant women who delivered from June 2012 to December 2016 at Wuhan Medical Care Center for Women and Children, Wuhan, China...
March 6, 2018: Journal of Clinical Gastroenterology
Shi Chen, Yingying Yang, Yimin Qv, Yun Zou, Huijuan Zhu, Fengying Gong, Yongwei Zou, Hongbo Yang, Linjie Wang, Bill Q Lian, Cynthia Liu, Yu Jiang, Chengsheng Yan, Jianqiang Li, Qing Wang, Hui Pan
Low birthweight (LBW) is closely associated with fetal and perinatal mortality and morbidity. We identified the risk factors of LBW and geographical differences in LBW incidence in 30 Chinese provinces in the present study.This study was a population-based, retrospective cohort study performed in 30 Chinese provinces. We used data from the free National Pre-pregnancy Checkups Project, which is a countrywide population-based retrospective cohort study. To identify regional differences in LBW incidence, we used the Qinling-Huaihe climate line to divide China into northern and southern sections and the Heihe-Tengchong economic line to divide it into eastern and western sections...
January 2018: Medicine (Baltimore)
Jiao Huang, Chu Zhang, Qinxian Guo, Xianfeng Zhang, Lizhen Ma, Yuhong Zhan, Yu Chen
BACKGROUND: Lesch-Nyhan syndrome (LNS) is a congenital X-linked recessive neurogenetic disorder caused by mutations in the hypoxanthine-guanine phosphoribosyltransferase (HPRT) gene. The main clinical manifestation includes hyperuricemia, juvenile-onset gouty arthritis, and neurological developmental disorders. Studies have reported more than 400 HPRT gene mutation sites, but the incidence of LNS in the Chinese population is extremely low. METHODS: Here we report a 16-year-old male patient who suffered neurological dysfunction at an early age and gouty arthritis in his youth...
January 1, 2018: Clinical Laboratory
Peng Fei, Yichao Jiang, Shaoying Gong, Ran Li, Yan Jiang, Xiujuan Yuan, Ziyuan Wang, Huaibin Kang, Md Aslam Ali
Cronobacter species (formerly Enterobacter sakazakii) are emerging opportunistic bacterial pathogens that can infect both infants and adults. This study was conducted to isolate and genotype diverse Cronobacter species from drinking water, chilled fresh pork, powdered infant formula, instant noodles, cookies, fruits, vegetables, and dishes in Northeast China and to evaluate the antibiotic resistance and susceptibility of the isolates. Thirty-four Cronobacter strains were isolated and identified: 21 C. sakazakii isolates (61...
February 23, 2018: Journal of Food Protection
Mengying Wang, Ruogu Meng, Zhuqing Wang, Dongjing Liu, Hui Huang, Chuyun Kang, Hongtian Li, Tao Wu, Siyan Zhan
Background: Oral clefts (OCs) are common human birth defects. Children with OCs in underdeveloped regions are more likely to suffer from poverty and hardship in their future lives. Here, we attempted to estimate the prevalence of OCs among live births in Gansu Province in 2008 to understand the epidemiologic pattern of the disease. Methods: A cross-sectional study was conducted from January 2008 to December 2008 in Gansu Province. The live births delivered between January and December 2008 with OCs were investigated through face-to-face questionnaire survey...
February 23, 2018: International Journal of Environmental Research and Public Health
Jin Yan, Zhenyan Gao, Ju Wang, Wenjuan Ma, Xiaolan Ying, Cancan Zhou, Chonghuai Yan
To explore the potential environmental and dietary factors during pregnancy affecting low-level prenatal lead exposure, we conducted a longitudinal study in Wujiang City, China. A total of 1976 mother-infant pairs were included from 2009 to 2010. An interviewed questionnaire was conducted and cord blood samples were collected. The geometric means of cord blood lead level was 30.3 μg/L (95% CI, 29.8-30.8) with 99.24% below 100 μg/L. Maternal age, passive smoking, and living in the countryside were significantly associated with cord blood lead concentrations...
February 23, 2018: Environmental Science and Pollution Research International
Yifan Duan, Zhenyu Yang, Jianqiang Lai, Dongmei Yu, Suying Chang, Xuehong Pang, Shan Jiang, Huanmei Zhang, Ye Bi, Jie Wang, Robert W Scherpbier, Liyun Zhao, Shian Yin
Appropriate infant and young child feeding could reduce morbidity and mortality and could improve cognitive development of children. However, nationwide data on exclusive breastfeeding and complementary feeding status in China are scarce. The aim of this study was to assess current exclusive breastfeeding and complementary feeding status in China. A national representative survey (Chinese National Nutrition and Health Survey) of children aged under 6 years was done in 2013. Stratified multistage cluster sampling was used to select study participants...
February 22, 2018: Nutrients
Hongxiu Liu, Shi Lu, Bin Zhang, Wei Xia, Wenyu Liu, Yang Peng, Hongling Zhang, Kangbing Wu, Shunqing Xu, Yuanyuan Li
Maternal arsenic exposure leads to adverse birth outcomes, but the critical window of this susceptibility keeps unclear. To determine whether the associations between maternal arsenic exposure and birth outcomes were trimester-specific, we conducted a birth cohort study of 1390 women from 2014 to 2016 in Wuhan, China. We examined associations between total urinary arsenic concentrations in three trimesters and birth weight, birth length and the risk of small for gestational age (SGA), and the differences of these associations across trimesters using generalized estimating equations...
February 17, 2018: Environmental Pollution
Yanjian Wan, Wei Xia, Shunyi Yang, Xinyun Pan, Zhenyu He, Kurunthachalam Kannan
Bisphenol S (BPS) is an emerging environmental contaminant. The occurrence of this compound in humans and the environment is not well described. In this study, 120 surface water samples and 240 human serum samples were collected along the Yangtze River in 2015 for the determination of the occurrence of BPS. Surface water and human serum samples were extracted by solid phase extraction and liquid-liquid extraction, respectively, and analyzed by ultra-high performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS)...
February 9, 2018: Chemosphere
Na Liu, Catherine Yen, Tao Huang, Pengwei Cui, Jacqueline E Tate, Baoming Jiang, Umesh D Parashar, Zhao-Jun Duan
INTRODUCTION: In China, rotavirus is the leading cause of diarrhea hospitalizations among children aged <5 years. A locally manufactured rotavirus vaccine is available for private market use, but little is known about its coverage. Given the impending availability of newer rotavirus vaccines, we evaluated intussusception rates among children aged <2 years to better understand intussusception epidemiology for future vaccine safety monitoring. METHODS: We conducted a retrospective review at 4 hospitals in Chenzhou City of Hunan Province and Kaifeng City of Henan Province...
February 10, 2018: Vaccine
Ling Zhang, Wenkuan Liu, Donglan Liu, Dehui Chen, Weiping Tan, Shuyan Qiu, Duo Xu, Xiao Li, Tiantian Liu, Rong Zhou
OBJECTIVES: Human metapneumovirus (HMPV) is one of the most important respiratory viral pathogens affecting infants and children worldwide. Our study describes the epidemiological and clinical characteristics of HMPV present in patients hospitalised with acute respiratory illness (ARI) in Guangzhou, Southern China. STUDY DESIGN: A cross-sectional study. SETTING: Two tertiary hospitals in Guangzhou. PARTICIPANTS AND METHODS: Throat swabs were collected over a 3-year period from 5133 paediatric patients (≤14 years) hospitalised with ARI...
February 6, 2018: BMJ Open
Y Li, Y P Dong, D Zhang, F Q Li
Objective: Laboratory-based characterization and traceability were performed on an outbreak of necrotising enterocolitis (NEC) happened in a maternal and child health care hospital in China. Methods: Thirty-seven samples were collected from 3 NEC cases, that the clinical manifestations was bloody stools. Clostridium spp . isolation and identification were carried out on stool, breast milk, milk-based infant powder and environmental swab samples collected during NEC outbreak from October to November in 2016...
February 6, 2018: Zhonghua Yu Fang Yi Xue za Zhi [Chinese Journal of Preventive Medicine]
Y Cui, J Q Gao, A Yue, L Tang, R F Luo, Rozelle Scott
Objective: To investigate the development status and risk factors of infants and toddlers in rural China. Methods: In this cohort study, 603 infants (6-12 months of age, Phase Ⅰ) in the rural areas of QinLing-Bashan (Qin-Ba) in Shaanxi were recruited in the control group that received no intervention from April 2013 to October 2015. Three follow-up visits were performed every six months (Phase Ⅱ(12-18 months of age), Phase Ⅲ (18-24 months of age) and Phase Ⅳ(24-30 months of age)). In all the 4 phases (Ⅰ-Ⅳ), general data of the children and the families were collected by questionnaires, early childhood growth and development were assessed by door to door visits, children's hemoglobin levels were determined by laboratory tests, and the cognitive and motor development screening was conducted by the Bayley Scales of Infant and Toddler Development...
February 2, 2018: Zhonghua Er Ke za Zhi. Chinese Journal of Pediatrics
Shan Shan, Fuqian Cui, Jidong Jia
Chronic hepatitis B virus (HBV) infection is an enormous economic and social burden. Asian countries such as Vietnam, Mongolia, Laos, China, the Philippines, South Korea, Singapore and Cambodia have high or high-intermediate HBsAg prevalence. Most of the chronic HBV carriers in this region acquire their infection during early childhood or through mother-to-child transmission (MTCT). Asia has been highly successful in controlling HBV in the last 2 decades. For example, China has adopted a comprehensive strategy to control HBV and has offered universal HBV vaccination to infants since 1992...
February 2018: Liver International: Official Journal of the International Association for the Study of the Liver
Hua Zhou, Jinchun He, Bin Wu, Datian Che
BACKGROUND: This study aimed to evaluate the cost-effectiveness of the 13-valent pneumococcal conjugate vaccine (PCV-13) compared to a no vaccination strategy in Chinese infants. METHODS: A Markov process model was developed to examine the outcomes of PCV-13 against a no vaccination strategy using data and assumptions adapted for relevance to China. Outcomes over a lifetime horizon are presented. One-way and probabilistic sensitivity analyses were performed to determine the uncertainty...
February 9, 2018: Human Vaccines & Immunotherapeutics
Xianghui Cao, Yonglong Lu, Yueqing Zhang, Kifayatullah Khan, Chenchen Wang, Yvette Baninla
Hexabromocyclododecanes (HBCDs) are the subject of recent interest and potential risk assessment particularly in China due to its ubiquitous existence in a variety of environmental media. This paper reviews the recent studies conducted on HBCDs in different environmental media (air, soil, water, river sediment, sewage sludge, biota and daily food) in China. At the same time, human health risks via food and occupational exposure of HBCDs in production plants, expanded polystyrene (EPS) and extruded polystyrene (XPS) plants were assessed...
February 2, 2018: Environmental Pollution
N Yao, Q Zeng, Q Wang
OBJECTIVES: In order to gain further insight into the seroepidemiology of Bordetella pertussis infection and immunity against diphtheria in Chongqing, China, the concentrations of antibodies to pertussis toxin (PT) and diphtheria toxin (DT) were investigated in a healthy population. STUDY DESIGN: Cross-sectional study. METHODS: In total, 1080 healthy people were recruited into this study. Sera antibodies to DT and PT were measured quantitatively using commercial enzyme-linked immunosorbent assay kits...
February 1, 2018: Public Health
Qing-Hong Meng, Jie Luo, Fan Yang, Ying-Jie Shen, Li Li, Li-Jun Li, Wei Shi, Ya-Juan Wang, Kai-Hu Yao
BACKGROUND: To investigate the level of pertussis-related antibodies in pregnant women and newborns. METHODS: A total of 286 serum samples from healthy pregnant women and 221cord samples from newborns were collected in 2016 in Beijing. A routinely blood sample from pregnant women was obtained at 35 weeks of gestational age, and cord samples were collected in 20 min after delivery. The values from cord samples were used as the infant values. Anti-pertussis toxin (PT) IgG concentration was measured by ELISA (Euroimmun, Lübeck, Germany) using purified PT as a coating antigen...
February 5, 2018: Pediatric Infectious Disease Journal
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