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https://www.readbyqxmd.com/read/29777329/population-pharmacokinetics-of-theophylline-in-adult-chinese-patients-with-asthma-and-chronic-obstructive-pulmonary-disease
#1
Yanjiao Ma, Ling Xue, Xin Chen, Yingbo Kang, Yong Wang, Liqing Wang
Background Theophylline has a narrow therapeutic range and large interindividual variability in blood levels, so a thorough understanding of its pharmacokinetic characteristics is essential. Population pharmacokinetic (PPK) approaches could achieve it and many PPK studies of theophylline have been reported in infants. However, none was conducted in Chinese adults and none has explored the effect of CYP1A2 genotypes on the PPK characteristics of theophylline in adults. Objective To evaluate the PPK characteristics of theophylline and to assess the possible influence of covariates, including CYP1A2 genotypes, on theophylline clearance in Chinese adult patients...
May 18, 2018: International Journal of Clinical Pharmacy
https://www.readbyqxmd.com/read/29777102/a-virus-like-particle-based-tetravalent-vaccine-for-hand-foot-and-mouth-disease-elicits-broad-and-balanced-protective-immunity
#2
Wei Zhang, Wenlong Dai, Chao Zhang, Yu Zhou, Pei Xiong, Shuxia Wang, Xiaohua Ye, Qingwei Liu, Dongming Zhou, Zhong Huang
Hand, foot, and mouth disease (HFMD) is an infectious disease that mainly affects infants and children, causing considerable morbidity and mortality worldwide. HFMD is commonly caused by enterovirus 71 (EV71) and coxsackieviruses A16 (CVA16), A6 (CVA6), and A10 (CVA10). Formalin-inactivated EV71 vaccines are currently available in China; however, these vaccines fail to confer cross-protection against infections by other HFMD-causing enteroviruses, highlighting the necessity of developing a multivalent HFMD vaccine...
May 18, 2018: Emerging Microbes & Infections
https://www.readbyqxmd.com/read/29773698/protocol-for-the-validation-of-sensitivity-and-specificity-of-the-cow-s-milk-related-symptom-score-comiss-against-open-food-challenge-in-a-single-blinded-prospective-multicentre-trial-in-infants
#3
Yvan Vandenplas, Rajat Mukherjee, Christophe Dupont, Philippe Eigenmann, Arne Høst, Mikael Kuitunen, Carmen Ribes-Koninkx, Neil Shah, Hania Szajewska, Andrea von Berg, Ralf G Heine, Zheng-Yan Zhao
INTRODUCTION: The symptoms of cow's milk protein allergy (CMPA) in infancy can be non-specific which may delay a correct diagnosis and cause adverse clinical outcomes. The diagnosis of non-IgE-mediated CMPA is particularly complex as it involves a 2 to 4 week elimination diet followed by oral food challenge (OFC). The Cow's Milk-related Symptom Score (CoMiSS) is a clinical resource for primary healthcare providers which aims to increase awareness of CMPA symptoms to facilitate an earlier diagnosis...
May 17, 2018: BMJ Open
https://www.readbyqxmd.com/read/29766979/playing-it-cool-characterizing-social-play-bout-termination-and-candidate-play-signals-of-juvenile-and-infant-tibetan-macaques-macaca-thibetana
#4
Kaitlin R Wright, Jessica A Mayhew, Lori K Sheeran, Jake A Funkhouser, Ronald S Wagner, Li-Xing Sun, Jin-Hua Li
Play behaviors and signals during playful interactions with juvenile conspecifics are important for both the social and cognitive development of young animals. The social organization of a species can also influence juvenile social play. We examined the relationships among play behaviors, candidate play signals, and play bout termination in Tibetan macaques (Macaca thibetana) during juvenile and infant social play to characterize the species play style. As Tibetan macaques are despotic and live in groups with strict linear dominance hierarchies and infrequent reconciliation, we predicted that play would be at risk of misinterpretation by both the individuals engaged in the play bout and by those watching, possibly leading to injury of the players...
July 18, 2018: Zoological Research
https://www.readbyqxmd.com/read/29757383/considerations-of-antiviral-treatment-to-interrupt-mother-to-child-transmission-of-hepatitis-b-virus-in-china
#5
Fuqiang Cui, Joseph Woodring, Polin Chan, Fujie Xu
Background: Treating high-risk women with antivirals in their third trimester is a promising intervention to further reduce perinatal transmission in neonates born to hepatitis B surface antigen positive [HBsAg(+)] mothers. Methods: We estimated the number of perinatal infections based on coverage and effectiveness of hepatitis B immunization. We compared cost-effectiveness of different approaches to identify high-risk women for antiviral treatment, by region and urban/rural residence...
May 10, 2018: International Journal of Epidemiology
https://www.readbyqxmd.com/read/29741208/induction-of-labour-for-improving-birth-outcomes-for-women-at-or-beyond-term
#6
REVIEW
Philippa Middleton, Emily Shepherd, Caroline A Crowther
BACKGROUND: Beyond term, the risks of stillbirth or neonatal death increase. It is unclear whether a policy of labour induction can reduce these risks. This Cochrane review is an update of a review that was originally published in 2006 and subsequently updated in 2012 OBJECTIVES: To assess the effects of a policy of labour induction at or beyond term compared with a policy of awaiting spontaneous labour or until an indication for birth induction of labour is identified) on pregnancy outcomes for infant and mother...
May 9, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29727842/concentrations-of-organochlorine-pesticides-in-cord-serum-of-newborns-in-wuhan-china
#7
Jing Fang, Hongxiu Liu, Hongzhi Zhao, Shunqing Xu, Zongwei Cai
Organochlorine pesticides (OCPs) had been widely used in China before they were banned decades ago due to the concern of the toxicology to human. Previous reports showed that OCPs were still often detectable in human bodies. However, there is limited study concerning the body burden of OCPs in infants and fetus in China. In this study, the prenatal exposure to OCPs was evaluated by measuring OCPs in cord serum. A total of 1046 cord serum samples were collected in Wuhan during 2014 and 2015, and analyzed for the concentrations of hexachlorocyclohexanes (HCHs), dichlorodiphenyltrichloroethanes (DDTs), dichlorodiphenyldichloroethanes (DDDs) and dichlorodiphenyldichloroethylenes (DDEs) by using gas chromatography-tandem mass spectrometry (GC-MS/MS)...
May 1, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/29727794/educational-videos-for-practitioners-attending-baby-friendly-hospital-initiative-workshops-supporting-breastfeeding-positioning-attachment-and-hand-expression-skills-effects-on-knowledge-and-confidence
#8
Louise M Wallace, Yuanying Ma, Li Qian Qiu, Orla M Dunn
UNICEF Baby Friendly Initiative (BFHI) is the global standard for maternity and community services requiring all practitioners to be trained to support mothers in the essential skills of supporting positioning and attachment, and hand expression. These studies aim to rigorously assess knowledge in nurses, midwives, and doctors in these skills, tested before and after watching short videos demonstrating these skills. Practitioners were attending BFHI education, and the video study was additional. In Phase 1 clinicians in England were randomised to one of two videos (practitioner role play or clinical demonstration)...
April 26, 2018: Nurse Education in Practice
https://www.readbyqxmd.com/read/29723482/factors-affecting-breastfeeding-outcomes-at-six-months-in-preterm-infants
#9
Ying Wang, Carrie-Ellen Briere, Wanli Xu, Xiaomei Cong
BACKGROUND: Preterm mother-infant dyads often face many obstacles to breastfeeding. Preterm infants are at highest risk for low rates of exclusive breastfeeding. Research Aim: To determine the prevalence of breastfeeding at 6 months among preterm infants and to identify factors that influenced mothers' breastfeeding practices. METHODS: A longitudinal observational study was conducted in a metropolitan hospital in Beijing, China. Mothers ( N = 270) and their preterm infants ( N = 280) were included in the study...
April 1, 2018: Journal of Human Lactation: Official Journal of International Lactation Consultant Association
https://www.readbyqxmd.com/read/29720104/prenatal-diagnosis-in-a-hereditary-peutz-jeghers-syndrome-family-with-high-cancer-risk
#10
Zhiqing Wang, Shu Liu, Siping Liu, Yadong Wang, Junsheng Chen, Baoping Wu
BACKGROUND: Peutz-Jeghers Syndrome (PJS) is a hereditary cancer predisposing syndrome caused by autosomal dominant mutations in the serine/threonine kinase 11 (STK11) gene and is associated with decreased life expectancy. Many families experience a poorer quality of life due to the psychological burden associated with the carrier status of their child. Therefore early genetic testing and confirmation of the diagnosis is important for patients' psychological status, as well as for clinical management, genetic counseling and possible prenatal family planning...
May 2, 2018: BMC Medical Genetics
https://www.readbyqxmd.com/read/29718853/pediatric-tuina-for-promoting-growth-and-development-of-preterm-infants-a-protocol-for-the-systematic-review-of-randomized-controlled-trail
#11
Xinghe Zhang, Taipin Guo, Bowen Zhu, Qing Gao, Hourong Wang, Xiantao Tai, Fujie Jing
BACKGROUND: Preterm infants are babies born alive before 37 weeks. Many survived infants concomitant with defects of growth and development, a lifetime of disability usually as following when insufficient intervention. In early intervention of preterm infants, pediatric Tuina shows good effect in many Chinese and some English clinical trials. This systematic review is aimed to evaluate the efficacy and safety of pediatric Tuina for promoting growth and development of preterm infants. METHODS: The electronic databases of Cochrane Library, MEDLINE, EBASE, Web of Science, Springer, World Health Organization International Clinical Trials Registry Platform, China National Knowledge Infrastructure, Chinese Biomedical Literature Database, Wan-fang database, Chinese Scientific Journal Database, and other databases will be searched from establishment to April 1, 2018...
May 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29715190/incidence-of-congenital-hypothyroidism-in-china-data-from-the-national-newborn-screening-program-2013-2015
#12
Kui Deng, Chunhua He, Jun Zhu, Juan Liang, Xiaohong Li, Xiaoyan Xie, Ping Yu, Nana Li, Qi Li, Yanping Wang
BACKGROUND: Congenital hypothyroidism (CH) is one of the most frequent, preventable causes of mental retardation. Little has been reported on the epidemiological characteristics of CH in China. We aimed to estimate the incidence of CH in China and investigate its geographical variation. METHODS: We analyzed data from the nationwide newborn screening program for CH between 2013 and 2015. Poisson regression was used to generate the odds ratios (ORs) and 95% confidence intervals (CIs) between the rates of CH and selected demographic characteristics and assess the potential association between CH incidence and geographical locations...
May 1, 2018: Journal of Pediatric Endocrinology & Metabolism: JPEM
https://www.readbyqxmd.com/read/29710778/occurrence-of-aflatoxin-m1-in-raw-milk-from-manufacturers-of-infant-milk-powder-in-china
#13
Songli Li, Li Min, Gang Wang, Dagang Li, Nan Zheng, Jiaqi Wang
This survey was performed to investigate the occurrence of aflatoxin M1 (AFM1) contamination of raw milk from manufacturers of infant milk powder in China. A total of 1207 raw milk samples were collected overall from four seasons of 2016 in Northeast China, Northwest China, Northern China, and Central China (11 provinces and one municipality). Results showed that 56 of the 1207 raw milk samples (4.64%) were positive for AFM1, which were obtained from Heilongjiang (two samples), Gansu (one sample), Shaanxi (46 samples), Beijing (one sample), and Hunan (six samples) provinces...
April 28, 2018: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29705756/cohort-profile-china-respiratory-illness-surveillance-among-pregnant-women-crisp-2015-2018
#14
Liling Chen, Suizan Zhou, Zhongwei Zhang, Yan Wang, Lin Bao, Yayun Tan, Falin Sheng, Ying Song, Ran Zhang, A Danielle Iuliano, Mark G Thompson, Carolyn M Greene, Jun Zhang
PURPOSE: We established the China Respiratory Illness Surveillance among Pregnant women (CRISP) to conduct active surveillance for influenza-associated respiratory illness during pregnancy in China from 2015 to 2018. Among annual cohorts of pregnant women, we assess the incidence of acute respiratory illness (ARI), influenza-like illness (ILI), laboratory-confirmed influenza virus infection and the seroconversion proportion during the winter influenza season. We also plan to examine the effect of influenza virus infection on adverse pregnancy, delivery and infant health outcomes with cumulative data from the three annual cohorts...
April 28, 2018: BMJ Open
https://www.readbyqxmd.com/read/29703037/fatal-malignant-pertussis-with-hyperleukocytosis-in-a-chinese-infant-a-case-report-and-literature-review
#15
Shu-Feng Tian, Hong-Mei Wang, Ji-Kui Deng
RATIONALE: Pertussis has re-emerged on a global scale and is an ongoing public health problem, even in countries with high rates of vaccination. Hyperleukocytosis [white blood cell (WBC) count >100 × 10/L] is a rare complication that strongly predicts mortality in cases of severe pertussis. PATIENT CONCERNS: We report a case of severe pertussis in an infant who initially presented with persistent cyanotic cough, tachypnea, and grunting. The infant's condition deteriorated rapidly, and she was transferred to the pediatric intensive care unit (PICU) during her third hour of hospitalization...
April 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29702992/gender-related-efficacy-of-pulmonary-surfactant-in-infants-with-respiratory-distress-syndrome-a-strobe-compliant-study
#16
Chen Chen, Tian Tian, Li Liu, Juan Zhang, Huiling Fu
Whether gender influences the efficacy of exogenous pulmonary surfactant (PS) for replacement therapy in newborns with respiratory distress syndrome (RDS) has not been well studied yet.Retrospective cohort study design. Data on PS therapy including blood gas, oxygenation function parameters, and therapy results were collected and analyzed from 370 infants diagnosed with RDS in 20 hospitals of the Northwest China Neonatal Collaboration from January 2011 to December 2011.Female infants were more sensitive to PS treatment than males...
April 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29689109/maternal-vitamin-d-deficiency-increases-the-risk-of-adverse-neonatal-outcomes-in-the-chinese-population-a-prospective-cohort-study
#17
Yuanliu Wang, Honghui Li, Min Zheng, Yubi Wu, Ting Zeng, Jinjian Fu, Dingyuan Zeng
BACKGROUND: Although vitamin D (vitD) deficiency is a common problem in pregnant women, in China, few studies have focused on the relationship between maternal vitD deficiency throughout the three trimesters and subsequent neonatal outcomes in China. METHODS: Between 2015 and 2016, maternal serum and neonate cord blood samples were collected from 1978 mother-neonate pairs from Liuzhou city. RESULTS: The mean concentrations of 25-hydroxy vitD (25(OH)D) were 16...
2018: PloS One
https://www.readbyqxmd.com/read/29686701/nontyphoidal-salmonella-gastroenteritis-in-a-tertiary-children-s-hospital-in-southern-china-characteristics-and-dietary-considerations
#18
Lu Ren, Min Yang, Lanlan Geng, Peiyu Chen, Huan Chen, Sitang Gong, Ding-You Li
Background: Nontyphoidal Salmonella infection is a common cause for acute bacterial gastroenteritis in children in China. There have been no reports of the prevalence of lactose intolerance or food allergies in children with nontyphoidal Salmonella infection. The aim of this study was to characterize nontyphoidal Salmonella gastroenteritis in a tertiary children's hospital and evaluate clinical presentation, lactose intolerance, and food allergies in children with prolonged nontyphoidal Salmonella gastroenteritis...
2018: Gastroenterology Research and Practice
https://www.readbyqxmd.com/read/29685021/detection-of-hand-foot-mouth-disease-and-its-spatial-temporal-epidemiological-characteristics-with-gis-platform
#19
X J Xu, Z Tang, L R Zeng, H Luo, Q Y Chen, L Li, Q Lou, X J He
The aim of this study is to investigate the main category of hand-foot-mouth (HFM) virus and analyze the distribution characteristics and susceptible population of HFM disease in China. Infants who have had HFM disease for less than 7 days were selected from the First Affiliated Hospital of Guangxi Medical University, Guangxi, China. Various specimens were collected from the infants, and EV71 and CA16 nucleic acid detections were performed using fluorescence quantitative assay. The positive results of the specimens were compared to determine the components of the pathogen...
March 2018: Journal of Biological Regulators and Homeostatic Agents
https://www.readbyqxmd.com/read/29684832/effect-of-non-nutritive-sucking-and-sucrose-alone-and-in-combination-for-repeated-procedural-pain-in-preterm-infants-a-randomized-controlled-trial
#20
Haixia Gao, Mei Li, Honglian Gao, Guihua Xu, Fang Li, Jing Zhou, Yunsu Zou, Honghua Jiang
BACKGROUND: Sucrose combined with non-nutritive sucking provided better pain relief than sucrose or non-nutritive sucking alone in a single painful procedure. However, whether the combination of non-nutritive sucking with sucrose could obtain a significant difference in analgesic effect of the repeated procedural pain than any single intervention has not been established. OBJECTIVE: To compare the effect of non-nutritive sucking and sucrose alone and in combination of repeated procedural pain in preterm infants...
April 7, 2018: International Journal of Nursing Studies
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