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https://www.readbyqxmd.com/read/28303225/identification-and-differentiation-of-major-components-in-three-different-sheng-ma-crude-drug-species-by-uplc-q-tof-ms
#1
Mengxue Fan, Kunming Qin, Fei Ding, Yuting Huang, Xiaoli Wang, Baochang Cai
Cimicifugae Rhizoma (Sheng ma) is a Ranunculaceae herb belonging to a composite family and well known in China. has been widely used in traditional Chinese medicine. The Pharmacopoeia of the People׳s Republic of China contains three varieties (Cimicifuga dahurica (Turcz.), Cimicifuga foetida L. and Cimicifuga heracleifolia Kom.) which have been used clinically as "Sheng-ma". However, the chemical constituents of three components of "Sheng-ma" have never been documented. In this study, a rapid method for the analysis of the main components of "Sheng-ma" was developed using ultra-high performance liquid chromatography with quadrupole-time-of-flight mass spectrometry (UPLC/Q-TOF-MS)...
March 2017: Acta Pharmaceutica Sinica. B
https://www.readbyqxmd.com/read/28301605/ocf-can-repress-tumor-metastasis-by-inhibiting-epithelial-mesenchymal-transition-involved-in-pten-pi3k-akt-pathway-in-lung-cancer-cells
#2
Ye Yang, Shuang Qiu, Lei Qian, Yuan Tian, Yingna Chen, Lei Bi, Weiping Chen
A component formula with definite compositions provides a new approach to treat various diseases. Salvia miltiorrhiza and Panax ginseng are widely used in China because of their antitumor properties. In the previous study, the optimizing component formula (OCF), prepared with salvianolic acids, ginsenosides, and ginseng polysaccharides (5, 10, and 5 mg·L-1, respectively) extracted from S. miltiorrhiza and P. ginseng on the basis of IC50 in lung cancer A549 cells and damage minimization on human bronchial epithelial cells in vitro...
2017: PloS One
https://www.readbyqxmd.com/read/28276001/allergy-march-of-chinese-children-with-infantile-allergic-symptoms-a-prospective-multi-center-study
#3
Qi Gao, Yi-Xin Ren, Yong-Ge Liu, Lin Ma, Xiao-Hong Gu, Wei-Xi Zhang, Li Liu, Xiao-Jia Zhai, Li Xiang, Kun-Ling Shen
BACKGROUND: Allergy march refers to progression of allergic diseases from infantile food allergy to the development of asthma and allergic rhinitis (AR). Evidence come mostly from studies in European countries. This study aimed to investigate allergy march in Chinese children with infantile food protein allergy (FPA) with a special focus on the effect of different formula interventions. METHODS: From 2008 to 2010, 153 infants diagnosed with FPA were recruited in five tertiary hospitals across China...
March 8, 2017: World Journal of Pediatrics: WJP
https://www.readbyqxmd.com/read/28272527/a-network-based-method-for-mechanistic-investigation-of-shexiang-baoxin-pill-s-treatment-of-cardiovascular-diseases
#4
Hai-Yang Fang, Hua-Wu Zeng, Li-Mei Lin, Xing Chen, Xiao-Na Shen, Peng Fu, Chao Lv, Qun Liu, Run-Hui Liu, Wei-Dong Zhang, Jing Zhao
Shexiang Baoxin Pill (SBP), a traditional Chinese medicine formula, is commonly used to treat cardiovascular disease (CVD) in China. However, the complexity of composition and targets has deterred our understanding of its mechanism of action. Using network pharmacology-based approaches, we established the mechanism of action for SBP to treat CVD by analyzing protein-protein interactions and pathways. The computational results were confirmed at the gene expression level in microarray-based studies. Two of the SBP's targets were further confirmed at the protein level by Western blot...
March 8, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28266999/combination-of-panaxadiol-and-panaxatriol-type-saponins-and-ophioponins-from-shenmai-formula-attenuates-lipopolysaccharide-induced-inflammatory-injury-in-cardiac-microvascular-endothelial-cells-by-blocking-nf-kappa-b-pathway
#5
Jinqiang Zhu, Yubin Liang, Shaoqian Yue, Guanwei Fan, Han Zhang, Meng Zhang
Vascular inflammatory injury leads to vascular endothelial dysfunction, thereby resulting in a variety of cardiovascular diseases (CVDs). Thus, attenuating vascular inflammatory injury has great significance for the prevention and treatment of CVDs. In China, Shenmai formula, a well-known ancient Chinese prescription, has been widely used to treat CVDs, such as coronary atherosclerosis and viral myocarditis. In vivo study has demonstrated that the optimal combination of 3 major active components from Shenmai formula, panaxadiol and panaxatriol type saponins and ophioponins, in a ratio of 1:2:2 might exert significant cardioprotective effects and anti-inflammatory activities...
March 2017: Journal of Cardiovascular Pharmacology
https://www.readbyqxmd.com/read/28260045/a-herbal-formula-sykt-reverses-doxorubicin%C3%A2-induced-myelosuppression-and-cardiotoxicity-by-inhibiting-ros%C3%A2-mediated-apoptosis
#6
Ting Chen, Hong-Mei Shen, Zhi-Yong Deng, Zuo-Zhang Yang, Rui-Lian Zhao, Li Wang, Zhi-Ping Feng, Chao Liu, Wen-Hui Li, Zhi-Jie Liu
Doxorubicin (DOX) is an antineoplastic drug widely used for the treatment of various types of cancer; however, it can induce severe side effects, such as myelosuppression and cardiotoxicity. Sanyang Xuedai (SYKT) is a natural medicine originating from an ancient prescription of the Dai nationality in Southwest China. With eight Chinese herbal medicines, including sanguis draconis, radix et rhizoma notoginseng, radix et rhizoma glycyrrhizae and radix angelicae sinensis as the primary ingredients, SYKT has been reported to possess numerous biological functions...
March 1, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28238437/impact-of-size-distributions-of-major-chemical-components-in-fine-particles-on-light-extinction-in-urban-guangzhou
#7
Yunjie Xia, Jun Tao, Leiming Zhang, Renjian Zhang, Shuanglin Li, Yunfei Wu, Junji Cao, Xiaojia Wang, Qingxia Ma, Zhe Xiong
To evaluate the impact of fine particulate matter (PM2.5) size distribution on aerosol chemical and optical properties, dominant chemical components including water-soluble inorganic ions (WSII), organic carbon (OC) and elemental carbon (EC) in PM1 and PM2.5, aerosol scattering coefficient (bsp), and aerosol absorption coefficient (bap) were collected synchronously at an urban site in Guangzhou, south China during a typical summer month in 2009 and a winter month in 2010. PM1 (sizes smaller than 1μm) constituted 77% and 63% of PM2...
February 23, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28216440/protective-effect-of-hwangryunhaedok-tang-water-extract-against-chronic-obstructive-pulmonary-disease-induced-by-cigarette-smoke-and-lipopolysaccharide-in-a-mouse-model
#8
Na-Rae Shin, Je-Won Ko, Sung-Hyeuk Park, Young-Kwon Cho, Sei-Ryang Oh, Kyung-Seob Ahn, Jung-Min Ryu, Jong-Choon Kim, Chang-Seob Seo, In-Sik Shin
ETHNOPHARMACOLOGICAL RELEVANCE: Hwangryunhaedok-tang is an oriental herbal formula treated to cure inflammation and gastric disorders in China, Japan, and Korea. We explored the protective effects of Hwangryunhaedok-tang water extract (HRWE) against airway pathophysiological changes caused by cigarette smoke (CS) and lipopolysaccharide (LPS) in a mouse. MATERIALS AND METHODS: We performed quantitative analyses of five marker components, namely geniposide, baicalin, coptisine, plamatine, and berberine, using high-performance liquid chromatography...
February 16, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28213110/effect-of-chinese-herbal-medicine-on-stroke-patients-with-type-2-diabetes
#9
Fuu-Jen Tsai, Tsung-Jung Ho, Chi-Fung Cheng, Xiang Liu, Hsinyi Tsang, Ting-Hsu Lin, Chiu-Chu Liao, Shao-Mei Huang, Ju-Pi Li, Cheng-Wen Lin, Jaung-Geng Lin, Jung-Chun Lin, Chih-Chien Lin, Wen-Miin Liang, Ying-Ju Lin
ETHNOPHARMACOLOGICAL RELEVANCE: Complications of type 2 diabetes (T2D) include stroke, which is a cerebrovascular disturbance characterized by reduced blood flow in the brain, leading to death or physical disability. Chinese herbal medicine (CHM) has been widely used in ancient China for the treatment of diabetes and stroke by supplementing Qi and activating blood circulation. AIM OF THE STUDY: This study aimed to investigate the frequencies and patterns of CHM treatment for stroke patients with T2D and the outcomes of long-term use in Taiwan...
March 22, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28141853/measuring-directional-urban-spatial-interaction-in-china-a-migration-perspective
#10
Fangzhou Li, Zhiming Feng, Peng Li, Zhen You
The study of urban spatial interaction is closely linked to that of economic geography, urban planning, regional development, and so on. Currently, this topic is generating a great deal of interest among researchers who are striving to find accurate ways to measure urban spatial interaction. Classical spatial interaction models lack theoretical guidance and require complicated parameter-adjusting processes. The radiation model, however, as proposed by Simini et al. with rigorous formula derivation, can simulate directional urban spatial interaction...
2017: PloS One
https://www.readbyqxmd.com/read/28122646/the-basic-reproductive-ratio-of-barbour-s-two-host-schistosomiasis-model-with-seasonal-fluctuations
#11
Shu-Jing Gao, Hua-Hua Cao, Yu-Ying He, Yu-Jiang Liu, Xiang-Yu Zhang, Guo-Jing Yang, Xiao-Nong Zhou
BACKGROUND: Motivated by the first mathematical model for schistosomiasis proposed by Macdonald and Barbour's classical schistosomiasis model tracking the dynamics of infected human population and infected snail hosts in a community, in our previous study, we incorporated seasonal fluctuations into Barbour's model, but ignored the effect of bovine reservoir host in the transmission of schistosomiasis. Inspired by the findings from our previous work, the model was further improved by integrating two definitive hosts (human and bovine) and seasonal fluctuations, so as to understand the transmission dynamics of schistosomiasis japonica and evaluate the ongoing control measures in Liaonan village, Xingzi County, Jiangxi Province...
January 25, 2017: Parasites & Vectors
https://www.readbyqxmd.com/read/28115698/transient-climate-and-ambient-health-impacts-due-to-national-solid-fuel-cookstove-emissions
#12
Forrest G Lacey, Daven K Henze, Colin J Lee, Aaron van Donkelaar, Randall V Martin
Residential solid fuel use contributes to degraded indoor and ambient air quality and may affect global surface temperature. However, the potential for national-scale cookstove intervention programs to mitigate the latter issues is not yet well known, owing to the spatial heterogeneity of aerosol emissions and impacts, along with coemitted species. Here we use a combination of atmospheric modeling, remote sensing, and adjoint sensitivity analysis to individually evaluate consequences of a 20-y linear phase-out of cookstove emissions in each country with greater than 5% of the population using solid fuel for cooking...
February 7, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28113140/simultaneous-determination-of-multiple-bioactive-components-of-bu-zhong-yi-qi-tang-in-rat-tissues-by-lc-ms-ms-application-to-a-tissue-distribution-study
#13
Min He, Wenwen Chen, Mengmeng Wang, Yu Wu, Jin Zeng, Zhirong Zhang, Shujiao Shen, Jian Jiang
A liquid chromatography coupled with electrospray ionization mass spectrometry method was developed and validated for simultaneous determination of seven bioactive constituents including astragaloside IV, calycosin, glycyrrhizic acid, enoxolone, saikosaponin D, ferulic acid and hesperiden in rats' various tissues using diclofenac as the internal standard (IS). Biological samples were pretreated by protein precipitation with acetonitrile. The chromatographic separation was carried out on a C18 column with a gradient mobile phase consisting of acetonitrile and water (containing 0...
January 18, 2017: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/28111216/rehmanniae-radix-in-osteoporosis-a-review-of-traditional-chinese-medicinal-uses-phytochemistry-pharmacokinetics-and-pharmacology
#14
REVIEW
Chenyue Liu, Rufeng Ma, Lili Wang, Ruyuan Zhu, Haixia Liu, Yubo Guo, Baosheng Zhao, Shangang Zhao, Jinfa Tang, Yu Li, Jianzhao Niu, Min Fu, Dongwei Zhang, Sihua Gao
ETHNOPHARMACOLOGICAL RELEVANCE: Emerging clinical usage and pharmacological effects have been achieved in using Rehmanniae Radix either singly or in combination with other herbs to treat skeletal diseases in traditional Chinese medicine (TCM) in the recent years. This study is aimed to provide a comprehensive review about the historical TCM interpretation of the action of Rehmanniae Radix in osteoporosis, its usage in clinical trials and osteoporotic models, its main phytochemical constituents, and its pharmacokinetics...
January 19, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28106847/combination-of-morroniside-and-diosgenin-prevents-high-glucose-induced-cardiomyocytes-apoptosis
#15
Wen-Xia Pi, Xiao-Peng Feng, Li-Hong Ye, Bao-Chang Cai
Cornus officinalis and Dioscorea opposita are two traditional Chinese medicines widely used in China for treating diabetes mellitus and its complications, such as diabetic cardiomyopathy. Morroniside (Mor) of Cornus officinalis and diosgenin (Dio) of Dioscorea opposita formed an innovative formula named M + D. The aims of the present study were to investigate myocardial protective effect of M + D on diabetic cardiomyopathy (DCM) through the inhibition of expression levels of caspase-3 protein, and identify the advantage of M + D compared with Mor, Dio, and the positive drug metformin (Met)...
January 19, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28104005/-analysis-on-the-unearthed-khotanese-remaining-prescription-p-2899v-in-the-library-grottoes-at-dunhuang
#16
X Y Wang
Khotanese remaining prescription P. 2889v was written in Khotanese.Because of the affinity between Khotan and Dunhuang, thus it appeared in the Dunhuang Library Grottoes.Traditional Indian medical work Siddhasāra copied around 982 and composed in Khotanese also unearthed in Dunhuang.It is speculated that the copy time of P. 2889v is slightly earlier than 982. The third formula prescription in P. 2889v is similar to the Kalyānaka found in the Siddhasāra and Daji Medicinal Oil Pill recorded in the Volume of Tibetan Medicine of the Chinese Medical Encyclopedia, demonstrating that this prescription had been circulating in the western region and Tibet, which indicates the spread of the Indian Ayurveda medicine in western China with profound influences...
September 28, 2016: Zhonghua Yi Shi za Zhi, Chinese Journal of Medical History
https://www.readbyqxmd.com/read/28103985/-ding-ganren-and-the-shanghai-professional-college-of-chinese-medicine
#17
Y E Ding
Ding Ganren (1866-1926), a distinguished representative of the Menghe Medical School, created a new school of unifying the Cold pathogenic disease with Warm febrile disease by adopting a new therapeutic method of integrating the Six-channel and Defense-qi-nutrient-blood syndrome differentiation, and simultaneously applying the classical formula with seasonal formula for treating against the exogenous febrile disease, which was quite an innovative approach. Ding Ganren paid high attention to the advancement of the education of Chinese medicine and founded the first official medical school in 1916 called the "Shanghai Professional College of Chinese Medicine" ...
November 28, 2016: Zhonghua Yi Shi za Zhi, Chinese Journal of Medical History
https://www.readbyqxmd.com/read/28101351/pro-inflammatory-effect-of-a-traditional-chinese-medicine-formula-with-potent-anti-cancer-activity-in-vitro-impedes-tumor-inhibitory-potential-in-vivo
#18
Lei Xia, Maksym Plachynta, Tangjingjun Liu, Xiao Xiao, Jialei Song, Xiaogang Li, Mu Zhang, Yao Yao, Heng Luo, Xiaojiang Hao, Yaacov Ben-David
Medicinal formulas are a part of the complex discipline of traditional Chinese medicine that has been used for centuries in China and East Asia. These formulas predominantly consist of the extracts isolated from herbal plants, animal parts and medicinal minerals. The present study aimed to investigate the impact of 150 formulas, used as non-prescription drugs in China, on the treatment of cancer. A formula was identified, C54, commonly used to treat sore throats, which exhibited marked growth inhibition in vitro, associated with cell cycle arrest and apoptosis...
December 2016: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/28056273/-study-on-the-contribution-rate-of-follow-up-formula-to-the-nutrient-intake-of-infants-and-young-children-aged-7-24-months-in-china
#19
H Z Li, H X Jia, D Liang, T T Deng, L T Niu, J H Han
Objective: To determine the contribution of follow-up formula (FUF) to the nutrient intake of 7-24-month-old infants and young children. Methods: The cluster random sampling method and the convenience sampling method were used in combination, and geographic and economic factors were taken into consideration. Four areas of China (Beijing, Hebei, Guangxi, Guangdong) were selected, with 120 infants chosen from each of these areas (half of which were 7-12 months old, and half were 13-24 months old). A dietary survey was completed by a continuous 24-hour weighing method over two days...
January 6, 2017: Zhonghua Yu Fang Yi Xue za Zhi [Chinese Journal of Preventive Medicine]
https://www.readbyqxmd.com/read/28053519/network-pharmacology-based-identification-of-key-pharmacological-pathways-of-yin-huang-qing-fei-capsule-acting-on-chronic-bronchitis
#20
Guohua Yu, Yanqiong Zhang, Weiqiong Ren, Ling Dong, Junfang Li, Ya Geng, Yi Zhang, Defeng Li, Haiyu Xu, Hongjun Yang
For decades in China, the Yin-Huang-Qing-Fei capsule (YHQFC) has been widely used in the treatment of chronic bronchitis, with good curative effects. Owing to the complexity of traditional Chinese herbal formulas, the pharmacological mechanism of YHQFC remains unclear. To address this problem, a network pharmacology-based strategy was proposed in this study. At first, the putative target profile of YHQFC was predicted using MedChem Studio, based on structural and functional similarities of all available YHQFC components to the known drugs obtained from the DrugBank database...
2017: International Journal of Chronic Obstructive Pulmonary Disease
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