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https://www.readbyqxmd.com/read/29312582/shexiang-tongxin-dropping-pill-protects-against-isoproterenol-induced-myocardial-ischemia-in-vivo-and-in-vitro
#1
Jianyong Qi, Wenjun Pan, Yafang Tan, Jiaru Luo, Dancai Fan, Juan Yu, Jiashin Wu, Minzhou Zhang
Shexiang Tongxin dropping pill (STDP) is a formulae of Chinese Medicine commonly used to treating angina pectoris in China. However, its mechanism of action is still yet unclear. This study investigated the roles of STDP on myocardial ischemia injury. We constructed a rat model of myocardial injury (isoproterenol subcutaneous injection, i.h, 85 mg/kg/day for 2 days), and compared among 4 groups: CON (control), ISO (ischemic injury model), MET (metoprolol), and STDP. Serum contents of Troponin I (cTnI), creatine kinase (CK), CK-MB, lactate dehydrogenase (LDH), alpha-hydroxybutyric dehydrogenase (α-HBD), and Aspartate Aminotransferase were detected and five STDP doses (1, 10, 100, 1000 and 10000 mg/kg/day) were chosen to obtain a dose-response curve...
December 12, 2017: Oncotarget
https://www.readbyqxmd.com/read/29300489/itraq-based-proteomic-analysis-reveals-recovery-of-impaired-mitochondrial-function-in-ischemic-myocardium-by-shenmai-formula
#2
Yi Wang, Yu Zhao, Wei Jiang, Xiaoping Zhao, Guanwei Fan, Han Zhang, Peiqiang Shen, Jiangmin He, Xiaohui Fan
Shenmai formula (SM) is a traditional medicinal remedy for treating cardiovascular diseases in China since 800 years ago, however its mechanism of action remains unclear. To explore the mechanism underlying cardioprotective effects of SM, iTRAQ-based proteomic approach was applied to analyze protein of myocardium in rats with myocardial ischemic injury. Upon treatment with SM and its two major components Red ginseng (RG) and Radix Ophiopogonis (OP), 101 differentially expressed proteins were filtered from a total of 711 detected and annotated proteins...
January 4, 2018: Journal of Proteome Research
https://www.readbyqxmd.com/read/29298511/chrysanthemum-indicum-inhibits-adipogenesis-and-activates-the-ampk-pathway-in-high-fat-diet-induced-obese-mice
#3
Sarmila Nepali, Ji-Yun Cha, Hyeon-Hui Ki, Hoon-Yeon Lee, Young-Ho Kim, Dae-Ki Kim, Bong-Joon Song, Young-Mi Lee
Chrysanthemum indicum (CI) is widely distributed in China and many parts of the tropical world, and has been reported to have antibacterial, antiviral, anti-oxidant and immunomodulatory effects, but no information is available on its effects on high fat diet (HFD)-induced obesity. This was undertaken to investigate the mechanism responsible for the effect of ethyl acetate fraction of CI (CIEA) on adipogenesis, in vitro and in vivo models of obesity. In the in vitro study, differentiating 3T3-L1 cells were treated with media to initiate differentiation (MDI) in the presence or absence of CIEA with different concentrations, and in the in vivo study, C57BL/6 mice were fed with HFD and administered CIEA daily for six weeks...
January 3, 2018: American Journal of Chinese Medicine
https://www.readbyqxmd.com/read/29258229/metabolomics-strategy-using-high-resolution-mass-spectrometry-reveals-novel-biomarkers-and-pain-relief-effect-of-traditional-chinese-medicine-prescription-wu-zhu-yu-decoction-acting-on-headache-modelling-rats
#4
Ran Liu, Huarong Xu, Xiaowen Zhang, Xiaotong Wang, Ziyue Yuan, Zhenyu Sui, Dong Wang, Kaishun Bi, Qing Li
Headache is a common episodic or chronic neurologic disorder. Treatment options and diagnosis are restricted by an incomplete understanding of disease pathology and the lack of diagnostic markers. Wu-Zhu-Yu decoction (WZYD), a traditional Chinese medicine (TCM) formula containing four TCM herbs, is commonly used in the treatment of headache in China. To deeply understand more about headache and investigate the pain-relief mechanism of WZYD, a comprehensive metabolomics study combined with multivariate data processing strategy was carried out...
December 18, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29245743/two-new-species-of-the-genus-i-thalassaphorura-i-bagnall-1949-collembola-onychiuridae-from-south-china-with-an-updated-key-to-world-species-of-the-genus
#5
Xin Sun, Anne Bedos, Louis Deharveng
Two new onychiurid species, Thalassaphorura microspinata sp. nov. and T. guangxiensis sp. nov., are reported from the karsts of south China (Guangxi). T. microspinata sp. nov. is similar to T. grandis Sun, Chen & Deharveng, 2010 in having the same dorsal and ventral pso formula, number of pseudocelli on subcoxae 1, number of chaetae in the distal whorl of tibiotarsi and number of p-chaetae between inner posterior pso on head; but it can be recognized by the smaller body size, shorter AS, 5 chaetae on baso-lateral part of labium, distinguishable S-chaetae and absence of chaetae on Th...
October 24, 2017: Zootaxa
https://www.readbyqxmd.com/read/29239567/regional-variation-of-alanine-aminotransferase-serum-levels-in-the-people-s-republic-of-china
#6
Peng Li, Miao Ge, Jing Jing, Dezhi Wei
The regional variation of the blood concentration of alanine aminotransferase (ALT), a sensitive predictor of liver damage, was studied in the People's Republic of China with reference to its potential association with environmental variables and geographic location. The research results presented are based on 121,977 blood samples from healthy adults in 93 cities in the country using correlation analysis, ridge regression estimation and trend surface analysis that were applied to explore if there was any tendency of spatial variation...
November 28, 2017: Geospatial Health
https://www.readbyqxmd.com/read/29234375/kidney-replenishing-herb-induces-socs-3-expression-via-erk-mapk-pathway-and-improves-growth-of-the-first-trimester-human-trophoblast-cells
#7
Chang-Ying Xing, De-Xiang Zhang, Sui-Qi Gui, Min-Fang Tao
Kidney-replenishing herb is a traditional medicine formula in China which has been widely used for clinical treatment of recurrent miscarriage. Our previous study showed that Kidney-replenishing herb could promote proliferation and inhibit apoptosis of the human first-trimester trophoblasts. In the present study, we further explored the potential mechanism and signal pathway of Kidney-replenishing herb on human trophoblast cells. Our research showed that Kidney-replenishing herb stimulated proliferation and reduced apoptosis of human trophoblast cells in vitro, and this appeared to be positive correlation with SOCS-3 transcription, suggesting that Kidney-replenishing herb regulated biological functions of human trophoblast cells by inducing SCOS-3 expression...
2017: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/29230986/-sixty-six-biallelic-genetic-markers-on-y-chromosome-by-maldi-tof-ms
#8
Y T Song, L Li, L N Zhang, R X Zhu, Y Liu, Y Lin
OBJECTIVES: To analyse the genetic polymorphisms of 66 biallelic genetic markers on Y chromosome in Eastern Chinese Han population, and evaluate their values in forensic application. METHODS: Genotyping of 66 biallelic genetic markers on Y chromosome was studied in 205 unrelated males of Eastern Chinese Han population by multiplex PCR combined matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF-MS). The allele frequencies on the loci to be tested were calculated by direct counting method, and the gene diversity (GD) and haplotype diversity (HD) were calculated by corresponding formulas...
June 2017: Fa Yi Xue za Zhi
https://www.readbyqxmd.com/read/29212627/how-do-infant-feeding-apps-in-china-measure-up-a-content-quality-assessment
#9
Jing Zhao, Becky Freeman, Mu Li
BACKGROUND: Globally, with the popularization of mobile phones, the number of health-related mobile phone apps has skyrocketed to 259,000 in 2016. In the digital era, people are accessing health information through their fingertips. In China, there are several apps that claim to provide infant feeding and nutrition guidance. However, the quality of information in those apps has not been extensively assessed. OBJECTIVE: We aimed to assess the quality of Chinese infant feeding apps using comprehensive quality assessment criteria and to explore Chinese mothers' perceptions on apps' quality and usability...
December 6, 2017: JMIR MHealth and UHealth
https://www.readbyqxmd.com/read/29202359/integrated-pharmacokinetics-of-ginsenosides-after-intravenous-administration-of-yiqifumai-powder-injection-in-rats-with-chronic-heart-failure-by-uflc-ms-ms
#10
Hao-Ran Zheng, Yang Chu, Da-Zheng Zhou, Ai-Chun Ju, Wei Li, Xiao Li, Yan Xia, Navaneethakrishnan Polachi, De-Kun Li, Shui-Ping Zhou, He Sun, Chang-Xiao Liu
YiQiFuMai powder injection (YQFM), derived from the classical traditional Chinese medicine (TCM) formula Shengmai San, is a modern preparation widely used to combat cardiovascular diseases, chronic heart failure (CHF) for example, in clinical practice in China. Ginsenosides are the major components of YQFM, which are responsible for its therapeutic effect. In this research, we developed a rapid, sensitive and simple method for simultaneous determination of ten ginsenosides from YQFM in CHF rat plasma with ultra-fast liquid chromatography tandem mass spectrometry (UFLC-MS/MS)...
November 23, 2017: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/29200916/study-on-tullbergiidae-of-tibet-china-i-metaphorura-mesaphorura-and-prabhergia-hexapoda-collembola
#11
Yun Bu, Yan Gao
The Tullbergiidae of Tibet is studied for the first time and the genus Metaphorura Bagnall, 1936 is firstly recorded in China. Metaphorura motuoensissp. n. from southeastern Tibet is described and illustrated. It is characterized by the presence of 1+1 pseudocelli on thoracic segment I, few vesicles (14 -16) on PAO, pseudocellar formula as 11/111/11111, all pseudocelli of type II, setae p4 on abdominal segment V as microsetae, weakly differentiated sensory seta p3 on abdominal segment V, absence of median process on Abd VI...
2017: ZooKeys
https://www.readbyqxmd.com/read/29196136/discovery-of-molecular-mechanism-of-a-clinical-herbal-formula-upregulating-serum-hdl-c-levels-in-treatment-of-metabolic-syndrome-by-in-vivo-and-computational-studies
#12
Meimei Chen, Fafu Yang, Jie Kang, Huijuan Gan, Xinmei Lai, Yuxing Gao
Decreased HDL cholesterol (HDL-c) is considered as an independent risk factor of cardiovascular disease in metabolic syndrome (Mets). Wendan decoction (WDD), a famous clinical traditional Chinese medicine formula in Mets in China, which can obviously up-regulate serum HDL-c levels in Mets. However, till now, the molecular mechanism of up-regulation still remained unclear. In this study, an integrated approach that combined serum ABCA1 in vivo assay, QSAR modeling and molecular docking was developed to explore the molecular mechanism and chemical substance basis of WDD upregulating HDL-c levels...
November 21, 2017: Bioorganic & Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/29195199/comparison-of-parameterizations-for-the-atmospheric-extinction-coefficient-in-lin-an-china
#13
Lin Jiang, Zefeng Zhang, Bin Zhu, Yan Shen, Honglei Wang, Shuangshuang Shi, Dandan Sha
A more precise atmospheric extinction coefficient would be advantageous for improving air quality (visibility) forecasting. In this study, the size distribution, chemical composition and relative humidity were measured in Lin'an from January 9 to 31, 2015. The merits and weaknesses of three parameterization schemes are discussed in this paper, including the non-linear fitting scheme, the IMPROVE (Interagency Monitoring of Protected Visual Environment) algorithm and the κ-elemental carbon (EC)-Mie model. Comparing the three schemes mentioned above, we find that the non-linear fitting equation requires the least amount of data, and its calculation process is the simplest...
November 28, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/29188884/model-construction-for-biological-age-based-on-a-cross-sectional-study-of-a-healthy-chinese-han-population
#14
W Zhang, L Jia, G Cai, F Shao, H Lin, Z Liu, F Liu, D Zhao, Z Li, X Bai, Z Feng, X Sun, X Chen
OBJECTIVES: Biological age (BA) has been proposed to evaluate the aging status in an objective way instead of chronological age (CA). The purpose of our study is to construct a more precise formula of BA in the cross-sectional study based on a largest-ever sample of our studies. This formula aims at better evaluation of body function and exploring the disciplines of aging in different genders and age stages. METHODS: A total of 1,373 healthy Chinese Han (age range, 19-93 years) were recruited from five cities in China, including 581 males and 792 females...
2017: Journal of Nutrition, Health & Aging
https://www.readbyqxmd.com/read/29183956/generalisability-of-an-online-randomised-controlled-trial-an-empirical-analysis
#15
Cheng Wang, Katie R Mollan, Michael G Hudgens, Joseph D Tucker, Heping Zheng, Weiming Tang, Li Ling
BACKGROUND: Investigators increasingly use online methods to recruit participants for randomised controlled trials (RCTs). However, the extent to which participants recruited online represent populations of interest is unknown. We evaluated how generalisable an online RCT sample is to men who have sex with men in China. METHODS: Inverse probability of sampling weights (IPSW) and the G-formula were used to examine the generalisability of an online RCT using model-based approaches...
November 28, 2017: Journal of Epidemiology and Community Health
https://www.readbyqxmd.com/read/29163386/evaluating-production-of-cyclopentyl-tetraethers-by-marine-group-ii-euryarchaeota-in-the-pearl-river-estuary-and-coastal-south-china-sea-potential-impact-on-the-tex86-paleothermometer
#16
Jin-Xiang Wang, Wei Xie, Yi Ge Zhang, Travis B Meador, Chuanlun L Zhang
TEX86 [TetraEther indeX of glycerol dialkyl glycerol tetraethers (GDGTs) with 86 carbon atoms] has been widely applied to reconstruct (paleo-) sea surface temperature. Marine Group I (MG-I) Thaumarchaeota were thought to be the primary source of GDGTs constituting the TEX86 formula; however, recent research has suggested that Marine Group II (MG-II) Euryarchaeota may also contribute significantly to the GDGT pool in the ocean. Little is known regarding the potential impact of MG-II Euryarchaeota-derived GDGTs on TEX86 values recorded in marine sediments...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29163383/microbial-taxa-distribution-is-associated-with-ecological-trophic-cascades-along-an-elevation-gradient
#17
Fei Yao, Shan Yang, Zhirui Wang, Xue Wang, Ji Ye, Xugao Wang, Jennifer M DeBruyn, Xue Feng, Yong Jiang, Hui Li
The elevational pattern of soil microbial diversity along mountain slopes has received considerable interest over the last decade. An increasing amount of taxonomic data on soil microbial community composition along elevation gradients have been collected, however the trophic patterns and environmental drivers of elevational changes remain largely unclear. Here, we examined the distribution patterns of major soil bacterial and fungal taxa along the northern slope of Changbai Mountain, Northeast China, at five typical vegetation types located between 740 and 2,691 m above sea level...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29119825/why-chinese-mothers-stop-breastfeeding-mothers-self-reported-reasons-for-stopping-during-the-first-six-months
#18
Ke Sun, Miaoxia Chen, Yuzhu Yin, Lingling Wu, Lingling Gao
The reasons why mothers in mainland China stop breastfeeding before their infants were six months old was investigated. Five hundred sixty-two mothers within two to three days after delivery in a hospital in Guangzhou, China, were followed up via telephone interview at one, four, and six months postpartum between January and August 2015 to assess their infant's feeding patterns and mother's reasons for breastfeeding cessation. Measures included the questionnaire about sociodemographic, psychosocial, and perinatal characteristics, the Breastfeeding Outcome Questionnaire and the Breastfeeding Self-efficacy Scale-Short Form...
September 2017: Journal of Child Health Care: for Professionals Working with Children in the Hospital and Community
https://www.readbyqxmd.com/read/29105500/prevalence-demographic-correlates-and-association-with-psychological-distress-of-night-eating-syndrome-among-chinese-college-students
#19
Jinbo He, Fang Huang, Jinjin Yan, Wen Wu, Zhihui Cai, Xitao Fan
Night eating syndrome (NES) has primarily been studied in Western societies, and the prevalence and associated factors of NES in China still remain unknown. This study examined the prevalence, demographic correlates, and association with psychological distress of NES among Chinese college students. By using the Chinese version of Night Eating Questionnaire (C-NEQ), data were collected from 909 university students sampled from three provinces in China. Results showed that the prevalence of NES was 2.8% (2.4% after excluding students with binge eating); the occurrence of NES was correlated with gender ([Formula: see text]) and the higher night eating scores were significantly correlated with higher psychological distress (rs = ...
November 6, 2017: Psychology, Health & Medicine
https://www.readbyqxmd.com/read/29101128/oral-chinese-herbal-medicine-for-psoriasis-vulgaris-protocol-for-a-randomised-double-blind-double-dummy-multicentre-clinical-trial
#20
Jingwen Deng, Danni Yao, Chuanjian Lu, Zehuai Wen, Yuhong Yan, Ziyang He, Huimei Wu, Hao Deng
INTRODUCTION: Psoriasis vulgaris is a common skin disease that is characterised by persistent localised erythematous scaly plaques. Yinxieling is a Chinese herbal formula for psoriasis that has been used for more than 20 years in China. To facilitate application, PSORI-CM01 was developed based on the optimisation and simplification of Yinxieling tablets performed in a previous study and in clinical practice. However, the scientific evidence regarding whether PSORI-CM01 is more effective for psoriasis than the original Yinxieling remains insufficient...
November 3, 2017: BMJ Open
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