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https://www.readbyqxmd.com/read/28213110/effect-of-chinese-herbal-medicine-on-stroke-patients-with-type-2-diabetes
#1
Fuu-Jen Tsai, Tsung-Jung Ho, Chi-Fung Cheng, Xiang Liu, Hsinyi Tsang, Ting-Hsu Lin, Chiu-Chu Liao, Shao-Mei Huang, Ju-Pi Li, Cheng-Wen Lin, Jaung-Geng Lin, Jung-Chun Lin, Chih-Chien Lin, Wen-Miin Liang, Ying-Ju Lin
ETHNOPHARMACOLOGICAL RELEVANCE: Complications of type 2 diabetes (T2D) include stroke, which is a cerebrovascular disturbance characterized by reduced blood flow in the brain, leading to death or physical disability. Chinese herbal medicine (CHM) has been widely used in ancient China for the treatment of diabetes and stroke by supplementing Qi and activating blood circulation. AIM OF THE STUDY: This study aimed to investigate the frequencies and patterns of CHM treatment for stroke patients with T2D and the outcomes of long-term use in Taiwan...
February 14, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28141853/measuring-directional-urban-spatial-interaction-in-china-a-migration-perspective
#2
Fangzhou Li, Zhiming Feng, Peng Li, Zhen You
The study of urban spatial interaction is closely linked to that of economic geography, urban planning, regional development, and so on. Currently, this topic is generating a great deal of interest among researchers who are striving to find accurate ways to measure urban spatial interaction. Classical spatial interaction models lack theoretical guidance and require complicated parameter-adjusting processes. The radiation model, however, as proposed by Simini et al. with rigorous formula derivation, can simulate directional urban spatial interaction...
2017: PloS One
https://www.readbyqxmd.com/read/28122646/the-basic-reproductive-ratio-of-barbour-s-two-host-schistosomiasis-model-with-seasonal-fluctuations
#3
Shu-Jing Gao, Hua-Hua Cao, Yu-Ying He, Yu-Jiang Liu, Xiang-Yu Zhang, Guo-Jing Yang, Xiao-Nong Zhou
BACKGROUND: Motivated by the first mathematical model for schistosomiasis proposed by Macdonald and Barbour's classical schistosomiasis model tracking the dynamics of infected human population and infected snail hosts in a community, in our previous study, we incorporated seasonal fluctuations into Barbour's model, but ignored the effect of bovine reservoir host in the transmission of schistosomiasis. Inspired by the findings from our previous work, the model was further improved by integrating two definitive hosts (human and bovine) and seasonal fluctuations, so as to understand the transmission dynamics of schistosomiasis japonica and evaluate the ongoing control measures in Liaonan village, Xingzi County, Jiangxi Province...
January 25, 2017: Parasites & Vectors
https://www.readbyqxmd.com/read/28115698/transient-climate-and-ambient-health-impacts-due-to-national-solid-fuel-cookstove-emissions
#4
Forrest G Lacey, Daven K Henze, Colin J Lee, Aaron van Donkelaar, Randall V Martin
Residential solid fuel use contributes to degraded indoor and ambient air quality and may affect global surface temperature. However, the potential for national-scale cookstove intervention programs to mitigate the latter issues is not yet well known, owing to the spatial heterogeneity of aerosol emissions and impacts, along with coemitted species. Here we use a combination of atmospheric modeling, remote sensing, and adjoint sensitivity analysis to individually evaluate consequences of a 20-y linear phase-out of cookstove emissions in each country with greater than 5% of the population using solid fuel for cooking...
February 7, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28113140/simultaneous-determination-of-multiple-bioactive-components-of-bu-zhong-yi-qi-tang-in-rat-tissues-by-lc-ms-ms-application-to-a-tissue-distribution-study
#5
Min He, Wenwen Chen, Mengmeng Wang, Yu Wu, Jin Zeng, Zhirong Zhang, Shujiao Shen, Jian Jiang
A liquid chromatography coupled with electrospray ionization mass spectrometry method was developed and validated for simultaneous determination of seven bioactive constituents including astragaloside IV, calycosin, glycyrrhizic acid, enoxolone, saikosaponin D, ferulic acid and hesperiden in rats' various tissues using diclofenac as the internal standard (IS). Biological samples were pretreated by protein precipitation with acetonitrile. The chromatographic separation was carried out on a C18 column with a gradient mobile phase consisting of acetonitrile and water (containing 0...
January 18, 2017: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/28111216/rehmanniae-radix-in-osteoporosis-a-review-of-traditional-chinese-medicinal-uses-phytochemistry-pharmacokinetics-and-pharmacology
#6
REVIEW
Chenyue Liu, Rufeng Ma, Lili Wang, Ruyuan Zhu, Haixia Liu, Yubo Guo, Baosheng Zhao, Shangang Zhao, Jinfa Tang, Yu Li, Jianzhao Niu, Min Fu, Dongwei Zhang, Sihua Gao
ETHNOPHARMACOLOGICAL RELEVANCE: Emerging clinical usage and pharmacological effects have been achieved in using Rehmanniae Radix either singly or in combination with other herbs to treat skeletal diseases in traditional Chinese medicine (TCM) in the recent years. This study is aimed to provide a comprehensive review about the historical TCM interpretation of the action of Rehmanniae Radix in osteoporosis, its usage in clinical trials and osteoporotic models, its main phytochemical constituents, and its pharmacokinetics...
January 19, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28106847/combination-of-morroniside-and-diosgenin-prevents-high-glucose-induced-cardiomyocytes-apoptosis
#7
Wen-Xia Pi, Xiao-Peng Feng, Li-Hong Ye, Bao-Chang Cai
Cornus officinalis and Dioscorea opposita are two traditional Chinese medicines widely used in China for treating diabetes mellitus and its complications, such as diabetic cardiomyopathy. Morroniside (Mor) of Cornus officinalis and diosgenin (Dio) of Dioscorea opposita formed an innovative formula named M + D. The aims of the present study were to investigate myocardial protective effect of M + D on diabetic cardiomyopathy (DCM) through the inhibition of expression levels of caspase-3 protein, and identify the advantage of M + D compared with Mor, Dio, and the positive drug metformin (Met)...
January 19, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28104005/-analysis-on-the-unearthed-khotanese-remaining-prescription-p-2899v-in-the-library-grottoes-at-dunhuang
#8
X Y Wang
Khotanese remaining prescription P. 2889v was written in Khotanese.Because of the affinity between Khotan and Dunhuang, thus it appeared in the Dunhuang Library Grottoes.Traditional Indian medical work Siddhasāra copied around 982 and composed in Khotanese also unearthed in Dunhuang.It is speculated that the copy time of P. 2889v is slightly earlier than 982. The third formula prescription in P. 2889v is similar to the Kalyānaka found in the Siddhasāra and Daji Medicinal Oil Pill recorded in the Volume of Tibetan Medicine of the Chinese Medical Encyclopedia, demonstrating that this prescription had been circulating in the western region and Tibet, which indicates the spread of the Indian Ayurveda medicine in western China with profound influences...
September 28, 2016: Zhonghua Yi Shi za Zhi, Chinese Journal of Medical History
https://www.readbyqxmd.com/read/28103985/-ding-ganren-and-the-shanghai-professional-college-of-chinese-medicine
#9
Y E Ding
Ding Ganren (1866-1926), a distinguished representative of the Menghe Medical School, created a new school of unifying the Cold pathogenic disease with Warm febrile disease by adopting a new therapeutic method of integrating the Six-channel and Defense-qi-nutrient-blood syndrome differentiation, and simultaneously applying the classical formula with seasonal formula for treating against the exogenous febrile disease, which was quite an innovative approach. Ding Ganren paid high attention to the advancement of the education of Chinese medicine and founded the first official medical school in 1916 called the "Shanghai Professional College of Chinese Medicine" ...
November 28, 2016: Zhonghua Yi Shi za Zhi, Chinese Journal of Medical History
https://www.readbyqxmd.com/read/28101351/pro-inflammatory-effect-of-a-traditional-chinese-medicine-formula-with-potent-anti-cancer-activity-in-vitro-impedes-tumor-inhibitory-potential-in-vivo
#10
Lei Xia, Maksym Plachynta, Tangjingjun Liu, Xiao Xiao, Jialei Song, Xiaogang Li, Mu Zhang, Yao Yao, Heng Luo, Xiaojiang Hao, Yaacov Ben-David
Medicinal formulas are a part of the complex discipline of traditional Chinese medicine that has been used for centuries in China and East Asia. These formulas predominantly consist of the extracts isolated from herbal plants, animal parts and medicinal minerals. The present study aimed to investigate the impact of 150 formulas, used as non-prescription drugs in China, on the treatment of cancer. A formula was identified, C54, commonly used to treat sore throats, which exhibited marked growth inhibition in vitro, associated with cell cycle arrest and apoptosis...
December 2016: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/28056273/-study-on-the-contribution-rate-of-follow-up-formula-to-the-nutrient-intake-of-infants-and-young-children-aged-7-24-months-in-china
#11
H Z Li, H X Jia, D Liang, T T Deng, L T Niu, J H Han
Objective: To determine the contribution of follow-up formula (FUF) to the nutrient intake of 7-24-month-old infants and young children. Methods: The cluster random sampling method and the convenience sampling method were used in combination, and geographic and economic factors were taken into consideration. Four areas of China (Beijing, Hebei, Guangxi, Guangdong) were selected, with 120 infants chosen from each of these areas (half of which were 7-12 months old, and half were 13-24 months old). A dietary survey was completed by a continuous 24-hour weighing method over two days...
January 6, 2017: Zhonghua Yu Fang Yi Xue za Zhi [Chinese Journal of Preventive Medicine]
https://www.readbyqxmd.com/read/28053519/network-pharmacology-based-identification-of-key-pharmacological-pathways-of-yin-huang-qing-fei-capsule-acting-on-chronic-bronchitis
#12
Guohua Yu, Yanqiong Zhang, Weiqiong Ren, Ling Dong, Junfang Li, Ya Geng, Yi Zhang, Defeng Li, Haiyu Xu, Hongjun Yang
For decades in China, the Yin-Huang-Qing-Fei capsule (YHQFC) has been widely used in the treatment of chronic bronchitis, with good curative effects. Owing to the complexity of traditional Chinese herbal formulas, the pharmacological mechanism of YHQFC remains unclear. To address this problem, a network pharmacology-based strategy was proposed in this study. At first, the putative target profile of YHQFC was predicted using MedChem Studio, based on structural and functional similarities of all available YHQFC components to the known drugs obtained from the DrugBank database...
2017: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/28047819/su-f-t-335-piecewise-uniform-dose-prescription-and-optimization-based-on-pet-ct-images
#13
G Liu, J Liu
PURPOSE: In intensity modulated radiation therapy (IMRT), the tumor target volume is given a uniform dose prescription, which does not consider the heterogeneous characteristics of tumor such as hypoxia, clonogen density, radiosensitivity, tumor proliferation rate and so on. Our goal is to develop a nonuniform target dose prescription method which can spare organs at risk (OARs) better and does not decrease the tumor control probability (TCP). METHODS: We propose a piecewise uniform dose prescription (PUDP) based on PET/CT images of tumor...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28039013/data-informed-analysis-of-2014-dengue-fever-outbreak-in-guangzhou-impact-of-multiple-environmental-factors-and-vector-control
#14
Yi Jing, Xia Wang, Sanyi Tang, Jianhong Wu
Epidemics of dengue fever in China were reported before 1940 and the outbreak of dengue fever in Guangdong province in 2014 is the most serious so far. The important question is what factors account for this serious outbreak, and how to evaluate the sensitivity of the multiple factors including weather variables and human actions on the dengue disease. Therefore, according to the relations among the temperature (daily mean temperature (DMT) and diurnal temperature range (DTR)), vector parameters and reproduction number we have proposed the analytical formula for the relative vector's capacity and effective reproduction number, and then we have the formula for the likelihood function by employing the generation interval-informed method...
December 27, 2016: Journal of Theoretical Biology
https://www.readbyqxmd.com/read/28038955/traditional-chinese-medicine-for-pulmonary-fibrosis-therapy-progress-and-future
#15
REVIEW
Liu-Cheng Li, Lian-Di Kan
ETHNOPHARMACOLOGICAL RELEVANCE: Pulmonary fibrosis (PF) is a chronic, debilitating and often lethal lung disorder. Despite the molecular mechanisms of PF are gradually clear with numerous researchers' efforts, few effective drugs have been developed to reverse human PF or even halt the chronic progression to respiratory failure. Traditional Chinese medicine (TCM), the main component of the medical practice used for more than 5000 years especially in China, often exerts wider action spectrum than previously attempted options in treating human diseases...
December 27, 2016: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28012621/development-and-application-of-a-sensitive-rapid-and-reliable-immunomagnetic-separation-pcr-detection-method-for-cronobacter-spp
#16
Qiming Chen, Yuanhong Li, Tingting Tao, Xiaomei Bie, Fengxia Lu, Zhaoxin Lu
Cronobacter spp. have been linked to clinical cases of infection in both adults and infants. Enrichment of Cronobacter spp. before detection has been necessary but is quite time consuming. Hence, we sought to develop an immunomagnetic separation (IMS) PCR method that could shorten the time of enrichment before the detection of Cronobacter spp. The polyclonal antibody used in this immunomagnetic separation was prepared based on the outer membrane protein A of Cronobacter sakazakii China Center of Industrial Culture Collection 21560 and had high specificity to the target...
February 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/27999264/systematic-understanding-of-mechanisms-of-a-chinese-herbal-formula-in-treatment-of-metabolic-syndrome-by-an-integrated-pharmacology-approach
#17
Meimei Chen, Fafu Yang, Xuemei Yang, Xinmei Lai, Yuxing Gao
Metabolic syndrome (MS) is becoming a worldwide health problem. Wendan decoction (WDD)-a famous traditional Chinese medicine formula-has been extensively employed to relieve syndromes related to MS in clinical practice in China. However, its pharmacological mechanisms still remain vague. In this study, a comprehensive approach that integrated chemomics, principal component analysis, molecular docking simulation, and network analysis was established to elucidate the multi-component and multi-target mechanism of action of WDD in treatment of MS...
December 16, 2016: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/27994974/distribution-and-characteristic-of-nitrite-dependent-anaerobic-methane-oxidation-bacteria-by-comparative-analysis-of-wastewater-treatment-plants-and-agriculture-fields-in-northern-china
#18
Zhen Hu, Ru Ma
Nitrite-dependent anaerobic methane oxidation (n-damo) is a recently discovered biological process which has been arousing global attention because of its potential in minimizing greenhouse gases emissions. In this study, molecular biological techniques and potential n-damo activity batch experiments were conducted to investigate the presence and diversity of M. oxyfera bacteria in paddy field, corn field, and wastewater treatment plant (WWTP) sites in northern China, as well as lab-scale n-damo enrichment culture...
2016: PeerJ
https://www.readbyqxmd.com/read/27990122/chinese-herbal-medicine-on-cardiovascular-diseases-and-the-mechanisms-of-action
#19
REVIEW
Cuiqing Liu, Yu Huang
Cardiovascular diseases are the principal cause of death worldwide. The potentially serious adverse effects of therapeutic drugs lead to growing awareness of the role of Chinese herbal medicine in the treatment of cardiovascular diseases. Chinese herbal medicine has been widely used in many countries especially in China from antiquity; however, the mechanisms by which herbal medicine acts in the prevention and treatment of cardiovascular diseases are far from clear. In this review, we briefly describe the characteristics of Chinese herbal medicine by comparing with western medicine...
2016: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/27982094/huangqin-tang-ameliorates-dextran-sodium-sulphate-induced-colitis-by-regulating-intestinal-epithelial-cell-homeostasis-inflammation-and-immune-response
#20
Ying Zou, Jiantao Lin, Wenyang Li, Zhuguo Wu, Zhiwei He, Guoliang Huang, Jian Wang, Caiguo Ye, Xiaoyan Cheng, Congcong Ding, Xuebao Zheng, Honggang Chi
Huangqin-tang (HQT) is a traditional Chinese medicine (TCM) formula widely used for the treatment of inflammatory bowel disease in China. However, the molecular mechanisms by which HQT protects the colon are unclear. We studied the protective effects of HQT and the underlying mechanisms in an experimental mouse model and in vitro. In vivo, dextran sodium sulphate (DSS)-induced acute and chronic colitis were significantly ameliorated by HQT as gauged by phenotypic, histopathologic and inflammatory manifestations of the disease...
December 16, 2016: Scientific Reports
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