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ApoB/apoA-I

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https://www.readbyqxmd.com/read/29748187/complete-and-partial-lcat-deficiency-are-differentially-associated-with-atherosclerosis
#1
Federico Oldoni, Damiano Baldassarre, Samuala Castelnuovo, Alice Ossoli, Mauro Amato, Julian van Capelleveen, G Kees Hovingh, Eric de Groot, Andrea Bochem, Sara Simonelli, Simone Barbieri, Fabrizio Veglia, Guido Franceschini, Jan Albert Kuivenhoven, Adriaan G Holleboom, Laura Calabresi
Background -Lecithin:cholesterol acyltransferase (LCAT) is the sole enzyme that esterifies cholesterol in plasma. Its role in the supposed protection from atherogenesis remains unclear since mutations in LCAT causing Fish-Eye Disease (FED) or Familial LCAT Deficiency (FLD) have been reported to be associated with more or instead less carotid atherosclerosis, respectively. This discrepancy may be associated with the loss of cholesterol esterification on only apolipoprotein (apo) A-I (FED) or on both apoA-I and apoB-containing lipoproteins (FLD), an aspect that has thus far not been investigated...
May 10, 2018: Circulation
https://www.readbyqxmd.com/read/29621036/comparative-evaluation-of-gemcabene-and-ppar-ligands-in-transcriptional-assays-of-peroxisome-proliferator-activated-receptors-implication-for-the-treatment-of-hyperlipidemia-and-cardiovascular-disease
#2
Charles L Bisgaier, Daniela C Oniciu, Rai Ajit K Srivastava
Gemcabene, a late-stage clinical candidate, has shown efficacy for LDL-C, non-HDL cholesterol, apoB, triglycerides and hsCRP reduction, all risk factors for cardiovascular disease (CVD). In rodents, gemcabene showed changes in targets, including apoC-III, apoA-I, peroxisomal enzymes, considered regulated via PPAR gene activation, suggesting a PPAR-mediated mechanism of action for the observed hypolipidemic effects observed in rodents and humans. In the current study, the gemcabene agonist activity against PPAR subtypes of human, rat and mouse were compared to known lipid lowering PPAR activators...
March 21, 2018: Journal of Cardiovascular Pharmacology
https://www.readbyqxmd.com/read/29550801/gender-related-effect-of-cold-water-swimming-on-the-seasonal-changes-in-lipid-profile-apob-apoa-i-ratio-and-homocysteine-concentration-in-cold-water-swimmers
#3
Z Checinska-Maciejewska, E Miller-Kasprzak, A Checinska, E Korek, M Gibas-Dorna, A Adamczak-Ratajczak, P Bogdanski, H Krauss
It has been proposed that regular cold swimming is associated with health benefits. However, the effect of cold adaptation on particular cardiovascular risk factors, within a single swimming season, remains unknown. Our aim was to evaluate the impact of cold water swimming on the seasonal changes in lipid profile and on apolipoprotein and homocysteine concentration in 34 cold water swimmers (CWS) aged 48 - 68 years. Blood samples were collected at the beginning (October), the middle (January), and the end (April) of the swimming season...
December 2017: Journal of Physiology and Pharmacology: An Official Journal of the Polish Physiological Society
https://www.readbyqxmd.com/read/29495288/intake-of-3-eggs-per-day-when-compared-to-a-choline-bitartrate-supplement-downregulates-cholesterol-synthesis-without-changing-the-ldl-hdl-ratio
#4
Bruno S Lemos, Isabel Medina-Vera, Christopher N Blesso, Maria Luz Fernandez
Cardiovascular disease (CVD) risk is associated with high concentrations of low-density lipoprotein cholesterol (LDL-C). The impact of dietary cholesterol on plasma lipid concentrations still remains a concern. The effects of egg intake in comparison to choline bitartrate supplement was studied in a young, healthy population. Thirty participants were enrolled for a 13-week intervention. After a 2-week run-in period, subjects were randomized to consume either 3 eggs/day or a choline bitartrate supplement (~400 mg choline for both treatments) for 4-weeks each...
February 24, 2018: Nutrients
https://www.readbyqxmd.com/read/29453140/serum-apolipoprotein-a-1-concentrations-and-the-prevalence-of-cardiovascular-autonomic-neuropathy-in-individuals-with-type-2-diabetes
#5
Jin Ook Chung, Seon-Young Park, Ji Hyun Han, Dong Hyeok Cho, Dong Jin Chung, Min Young Chung
OBJECTIVE: To evaluate the relationship between levels of serum apolipoproteins and the prevalence of cardiovascular autonomic neuropathy (CAN) in type 2 diabetes. METHODS: In total, 3199 individuals with type 2 diabetes were investigated in a cross-sectional study. The diagnosis of CAN was made based on the results of a cardiovascular reflex test. Serum apolipoprotein A-I (apoA-I) and apolipoprotein B (apoB) levels were measured. RESULTS: Serum apoA-1 levels were significantly low in individuals with CAN, but there was no significant association between serum apoB levels and CAN...
April 2018: Journal of Diabetes and its Complications
https://www.readbyqxmd.com/read/29440006/apob-apoa-i-ratio-is-associated-with-faster-hemodynamic-progression-of-aortic-stenosis-results-from-the-progressa-metabolic-determinants-of-the-progression-of-aortic-stenosis-study
#6
Lionel Tastet, Romain Capoulade, Mylène Shen, Marie-Annick Clavel, Nancy Côté, Patrick Mathieu, Marie Arsenault, Élisabeth Bédard, Alexe Tremblay, Marilie Samson, Yohan Bossé, Jean G Dumesnil, Benoit J Arsenault, Jonathan Beaudoin, Mathieu Bernier, Jean-Pierre Després, Philippe Pibarot
BACKGROUND: Previous studies reported that middle-aged patients with atherogenic lipoprotein-lipid profile exhibit faster progression of aortic valve stenosis (AS). The ratio of apolipoprotein B/apolipoprotein A-I (apoB/apoA-I) reflects the balance between atherogenic and anti-atherogenic lipoproteins. The aim of this study was to examine the association between apoB/apoA-I ratio and AS hemodynamic progression and to determine whether this association varies according to age. METHODS AND RESULTS: A total of 159 patients (66±13 years, 73% men) with AS were prospectively recruited in the PROGRESSA (Metabolic Determinants of the Progression of Aortic Stenosis) study...
February 10, 2018: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29393234/lipid-metabolism-in-patients-with-anti-n-methyl-d-aspartate-receptor-encephalitis
#7
Yaqing Shu, Bing Qin, Yue Xu, Xiaobo Sun, Zheng Chen, Jia Wang, Lisheng Peng, Wei Qiu, Zhengqi Lu, Aimin Wu
OBJECTIVE: Lipid metabolism has been implicated in autoimmune disorders, but its relationship with anti-N-methyl-D-aspartate receptor (anti-NMDAR) encephalitis is unclear. This study examined the association of serum lipids with anti-NMDAR encephalitis. METHODS: Serum lipid profiles and C-reactive protein (CRP) were evaluated in 68 patients with anti-NMDAR encephalitis, and 68 age- and sex-matched healthy controls (CTLs). Follow-up evaluations were conducted 3 months after admission in 32 of the 68 patients...
2017: Neuroimmunomodulation
https://www.readbyqxmd.com/read/29359590/association-of-carotid-intima-media-thickness-with-atherogenic-index-of-plasma-apo-b-apo-a-i-ratio-and-paraoxonase-activity-in-patients-with-non-alcoholic-fatty-liver-disease
#8
Reza Fadaei, Reza Meshkani, Hossein Poustchi, Soudabeh Fallah, Nariman Moradi, Ghodratollah Panahi, Shahin Merat, Taghi Golmohammadi
BACKGROUND: NAFLD patients have higher risk of atherosclerosis cardiovascular disease (ASCVD). apo B/apoA-I ratio and atherogenic index of plasma (AIP) have been suggested as biomarker for ASCVD. METHODS: apo A-I, apoB, aryl esterase (ARE) and paraoxonase (PON) activities and carotid intima media thickness (cIMT) were determined in 49 NAFLD patients and 33 controls. RESULTS: Plasma levels of apo A-I, adiponectin, ARE and PON activities decreased in NAFLD patients, while apo B, AIP and apoB/apo A-I ratio level were higher in NAFLD patients compared to controls...
January 23, 2018: Archives of Physiology and Biochemistry
https://www.readbyqxmd.com/read/29334727/apob-apoa-i-ratio-is-independently-associated-with-carotid-atherosclerosis-in-type-2-diabetes-mellitus-with-well-controlled-ldl-cholesterol-levels
#9
Ji Eun Jun, Young Ju Choi, Yong-Ho Lee, Dae Jung Kim, Seok Won Park, Byung Wook Huh, Eun Jig Lee, Sun-Ha Jee, Kyu Yeon Hur, Sung Hee Choi, Kap Bum Huh
BACKGROUND/AIMS: This study aimed to investigate whether the apolipoprotein (Apo) B/ApoA-I ratio is associated with carotid intima-media thickness (CIMT) in type 2 diabetes mellitus (T2DM) subjects with low density lipoprotein cholesterol (LDL-C) levels less than 100 mg/dL. METHODS: This cross-sectional study included 845 subjects aged with T2DM 40 to 75 years who had visited Huh's Diabetes Center in Seoul, Republic of Korea for CIMT measurement. Traditional fasting lipid profiles, ApoB and ApoA-I levels were examined...
January 2018: Korean Journal of Internal Medicine
https://www.readbyqxmd.com/read/29287689/present-therapeutic-role-of-cholesteryl-ester-transfer-protein-inhibitors
#10
REVIEW
Nicola Ferri, Alberto Corsini, Cesare R Sirtori, Massimiliano Ruscica
Therapeutic interventions aimed at increasing high-density lipoprotein (HDL) levels in order to reduce the residual cardiovascular (CV) risk of optimally drug treated patients have not provided convincing results, so far. Transfer of cholesterol from extrahepatic tissues to the liver appears to be the major atheroprotective function of HDL, and an elevation of HDL levels could represent an effective strategy. Inhibition of the cholesteryl ester transfer protein (CETP), raising HDL-cholesterol (HDL-C) and apolipoprotein A-I (apoA-I) levels, reduces low-density lipoprotein-cholesterol (LDL-C) and apoB levels, thus offering a promising approach...
February 2018: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://www.readbyqxmd.com/read/29241386/modified-risk-associations-of-lipoproteins-and-apolipoproteins-by-chronic-low-grade-inflammation
#11
Altan Onat, Aysem Kaya, Evin Ademoglu
Lipoproteins and the apolipoproteins (apo) that they carry are major determinants of cardiovascular diseases (CVD) as well as metabolic, renal and inflammatory chronic disorders either directly or through mediation of risk factors. The notion that elevated low-density lipoprotein cholesterol (LDL-C) and apoB levels are related to the acquisition of CVD and, high-density lipoprotein cholesterol (HDL-C) and apoA-I indicate protection against CVD has been challenged in the past decade. Advanced age, adiposity, ethnicity or impaired glucose intolerance rendered autoimmune activation in an environment of pro-inflammatory state/oxidative stress and may disrupt the linear risk association between lipoproteins...
January 2018: Expert Review of Cardiovascular Therapy
https://www.readbyqxmd.com/read/29206648/relationship-between-plasma-protein-s-levels-and-apolipoprotein-c-ii-in-japanese-middle-aged-obese-women-and-young-nonobese-women
#12
Yukiko Otsuka, Maiko Ueda, Eri Nakazono, Tomohide Tsuda, Xiuri Jin, Kenta Noguchi, Shihoko Sata, Hitomi Miyazaki, Shimako Abe, Katsumi Imai, Masako Iwamoto, Takashi Masuda, Ririko Moriguchi, Shuji Nakano, Hiroko Tsuda
: Protein S, a nonenzymatic cofactor to activated protein C, presents in two forms in plasma, free form and in a complex with C4b-binding protein. The aim of this study was to determine the association of plasma protein S levels with the variables related to cardiovascular disease risk. The relationships between plasma protein S levels with lipids, inflammation markers, and adiposity were first examined on middle-aged obese women (n = 62), then on young nonobese women (n = 160) to verify the findings in the obese women...
January 2018: Blood Coagulation & Fibrinolysis: An International Journal in Haemostasis and Thrombosis
https://www.readbyqxmd.com/read/29187200/apoa-i-a-ii-hdl-positively-associates-with-apob-lipoproteins-as-a-potential-atherogenic-indicator
#13
Toshimi Kido, Kazuo Kondo, Hideaki Kurata, Yoko Fujiwara, Takeyoshi Urata, Hiroshige Itakura, Shinji Yokoyama
BACKGROUND: We recently reported distinct nature of high-density lipoproteins (HDL) subgroup particles with apolipoprotein (apo) A-I but not apoA-II (LpAI) and HDL having both (LpAI:AII) based on the data from 314 Japanese. While plasma HDL level almost exclusively depends on concentration of LpAI having 3 to 4 apoA-I molecules, LpAI:AII appeared with almost constant concentration regardless of plasma HDL levels having stable structure with two apoA-I and one disulfide-dimeric apoA-II molecules (Sci...
November 29, 2017: Lipids in Health and Disease
https://www.readbyqxmd.com/read/29155052/characterization-of-covalent-modifications-of-hdl-apoproteins-by-endogenous-oxidized-phospholipids
#14
Detao Gao, Eugene A Podrez
High density lipoprotein (HDL) is cardioprotective, unless it is pathologically modified under oxidative stress. Covalent modifications of lipid-free apoA-I, the most abundant apoprotein in HDL, compromise its atheroprotective functions. HDL is enriched in oxidized phospholipids (oxPL) in vivo in oxidative stress. Furthermore, oxidized phospholipids can covalently modify HDL apoproteins. We have now carried out a systematic analysis of modifications of HDL apoproteins by endogenous oxPL. Human HDL or plasma were oxidized using a physiologically relevant MPO-H2 O2 -NO2 - system or AIPH, or were exposed to synthetic oxPL...
February 1, 2018: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/29152661/apolipoprotein-status-in-type-2-diabetes-mellitus-and-its-complications-review
#15
Puhong Zhang, Jialin Gao, Chun Pu, Yao Zhang
Dyslipidaemia in type 2 diabetes mellitus (T2DM) is characterized by high plasma triglyceride concentrations, reduced high‑density lipoprotein concentrations and increased small density low‑density lipoprotein concentrations. Dyslipidaemia may lead to cardiovascular disease (CVD) and other complications. Apolipoproteins mainly comprise six species, apolipoprotein (apo)A, apoB, apoC, apoD, apoE and apoM, which are important components of plasma lipoproteins that carry lipids and stabilize the structure of lipoproteins...
December 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29032752/association-between-apolipoproteins-ai-and-b-and-ultrasound-indicators-of-carotid-atherosclerosis
#16
Zeljko Zivanovic, Ivana Divjak, Mirjana Jovicevic, Tamara Rabi-Zikic, Biljana Radovanovic, Svetlana Ruzicka-Kaloci, Djordje Stevan Popovic, Edita Stokic, Ksenija Gebauer-Bukurov, Katarina Zivanovic-Vujcic, Petar Slankamenac
BACKGROUND: Apolipoproteins A-I and B (apoA-I and apoB) may be better indicators of the risk of cardiovascular and cerebrovascular diseases than conventional risk factors (RFs). The onset of ischemic stroke (IS) may be preceded by the development of atherosclerotic changes in carotid arteries, which can be detected by ultrasound. Only a certain % of patients with IS have an (underlying) carotid etiology. OBJECTIVE: The aim of our study was to determine the association between ultrasound indicators of carotid atherosclerosis and the presence of apolipoproteins and other biomarkers in patients with IS...
October 10, 2017: Current Vascular Pharmacology
https://www.readbyqxmd.com/read/28992985/apoa1-and-apob-polymorphisms-and-apolipoprotein-concentrations-as-biomarkers-of-risk-in-acute-coronary-syndrome-relationship-with-lipid-lowering-therapy-effectiveness
#17
Fidel Casillas-Muñoz, Yeminia Valle, José Francisco Muñoz-Valle, Diana Emilia Martínez-Fernández, Gabriela Lizet Reynoso-Villalpando, Héctor Enrique Flores-Salinas, Mara Anaís Llamas-Covarrubias, Jorge Ramón Padilla-Gutiérrez
BACKGROUND AND OBJECTIVE: Lipid metabolism alterations contribute to acute coronary syndrome (ACS). rs670, rs5070 and rs693 polymorphisms have shown to modify the risk of cardiovascular disease. Apolipoprotein A-I (ApoA-I) plays a major role in reverse cholesterol transport; apolipoprotein B (ApoB) contributes to accumulation of cholesterol in the plaque. The aim of this study was to investigate the association of rs670 and rs5070 polymorphisms of APOA1 and rs693 polymorphism of APOB with ACS and circulating levels of its proteins and find if ApoB/ApoA-I could be implemented as an independent parameter of risk for cardiovascular disease and as a biomarker of lipid-lowering therapy effectiveness in Mexican population...
October 6, 2017: Medicina Clínica
https://www.readbyqxmd.com/read/28972399/angptl3-serum-concentration-and-rare-genetic-variants-in-finnish-population
#18
Anna Tikka, Jari Metso, Matti Jauhiainen
Genetic variants of angiopoietin-like protein 3 (ANGPTL3) are associated with serum triglyceride (TG) and low-density lipoprotein cholesterol (LDL-C) concentration in GWASs. ANGPTL3 deficiency causes declined TG, total cholesterol (TC), LDL-C, high-density lipoprotein cholesterol (HDL-C), apolipoprotein B (apoB) and apolipoprotein A-I (apoA-I) serum concentration, a phenotype defined as familial combined hypolipidaemia (FHBL2). Our aim is to establish whether ANGPTL3 serum protein concentration correlates with lipoproteins and lipids in hyper- or hypolipidaemic subjects, and whether ANGPTL3 sequence variants are associated with untypical lipid profiles...
October 3, 2017: Scandinavian Journal of Clinical and Laboratory Investigation
https://www.readbyqxmd.com/read/28970513/hdl-cholesterol-efflux-normalised-to-apoa-i-is-associated-with-future-development-of-type-2-diabetes-from-the-cordioprev-trial
#19
Ruth Blanco-Rojo, Pablo Perez-Martinez, Javier Lopez-Moreno, Javier Martinez-Botas, Javier Delgado-Lista, Ben van-Ommen, Elena Yubero-Serrano, Antonio Camargo, Jose M Ordovas, Francisco Perez-Jimenez, Diego Gomez-Coronado, Jose Lopez-Miranda
This prospective study evaluated whether baseline cholesterol efflux is associated with future development of type 2 diabetes (T2DM) in cardiovascular patients. We measured cholesterol efflux in all CORDIOPREV study (NCT00924937) participants free of T2DM at baseline (n = 462) and assessed its relationship with T2DM incidence during a 4.5 years of follow-up. Cholesterol efflux was quantified by incubation of cholesterol-loaded THP-1 cells with the participants' apoB-depleted plasma. Disposition index was estimated as beta-cell function indicator...
October 2, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28958565/association-between-thyroid-function-and-lipid-profiles-apolipoproteins-and-high-density-lipoprotein-function
#20
Kyong Yeun Jung, Hwa Young Ahn, Sun Kyoung Han, Young Joo Park, Bo Youn Cho, Min Kyong Moon
BACKGROUND: Thyroid hormone regulates lipid metabolism. In particular, it has been reported to regulate plasma high-density lipoprotein cholesterol (HDL-C) levels and the activity of molecules involved in HDL metabolism. OBJECTIVE: We investigated changes in the concentrations of lipids and apolipoproteins and in the function of HDL according to acute dynamic changes in thyroid function. METHODS: Concentrations of plasma lipids and apolipoproteins, paraoxonase-1 activity, and cholesterol efflux were measured in 27 patients with differentiated thyroid carcinoma who underwent total thyroidectomy and radioactive iodine (RAI) treatment, at 3 distinct times: After surgery (baseline subclinical hyperthyroid state), on the day of undergoing RAI treatment (overt hypothyroid state), and 3 months post-RAI treatment (subclinical hyperthyroid state)...
September 4, 2017: Journal of Clinical Lipidology
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